MCID: ECC008
MIFTS: 25

Eccrine Sweat Gland Neoplasm

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Eccrine Sweat Gland Neoplasm

MalaCards integrated aliases for Eccrine Sweat Gland Neoplasm:

Name: Eccrine Sweat Gland Neoplasm 12 15
Malignant Eccrine Neoplasm 72
Eccrine Skin Neoplasm 12
Eccrine Neoplasm 72
Eccrine Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:173
NCIt 50 C6796
UMLS 72 C1333371 C1334577

Summaries for Eccrine Sweat Gland Neoplasm

MalaCards based summary : Eccrine Sweat Gland Neoplasm, also known as malignant eccrine neoplasm, is related to eccrine porocarcinoma and spiradenoma. An important gene associated with Eccrine Sweat Gland Neoplasm is KRT15 (Keratin 15), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include skin, and related phenotype is digestive/alimentary.

Related Diseases for Eccrine Sweat Gland Neoplasm

Diseases related to Eccrine Sweat Gland Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 eccrine porocarcinoma 30.5 LGR6 KRT15
2 spiradenoma 30.3 TP53 KRT7
3 hidrocystoma 30.3 KRT7 KRT15
4 papillary adenocarcinoma 29.8 TP53 KRT7
5 adenoid cystic carcinoma 29.2 TP53 KRT7 KRT5
6 eccrine acrospiroma 29.2 LUM KRT17 KRT15 KRT10
7 basal cell carcinoma 27.8 TP53 KRT7 KRT17 KRT15 KRT10
8 eccrine papillary adenoma 11.5
9 schopf-schulz-passarge syndrome 11.5
10 eccrine sweat gland cancer 11.4
11 apocrine adenocarcinoma 10.4 KRT5 KRT15
12 epidermolysis bullosa simplex with mottled pigmentation 10.4 KRT5 KRT10
13 epidermolysis bullosa simplex 10.4 KRT5 KRT10
14 malignant syringoma 10.4 KRT7 KRT15
15 epidermolysis bullosa simplex, dowling-meara type 10.4 KRT5 KRT10
16 nodular hidradenoma 10.4 KRT7 KRT10
17 mucinous tubular and spindle renal cell carcinoma 10.3 KRT7 KRT10
18 inverted transitional papilloma 10.3 KRT7 KRT5
19 ceruminoma 10.3 KRT7 KRT5
20 benign breast adenomyoepithelioma 10.3 KRT7 KRT5
21 conjunctival squamous cell carcinoma 10.3 TP53 KRT15
22 breast adenomyoepithelioma 10.3 KRT7 KRT5
23 balloon cell malignant melanoma 10.3 KRT7 KRT5
24 benign mesothelioma 10.3 KRT7 KRT5
25 middle ear adenoma 10.3 KRT7 KRT5
26 bile duct mucoepidermoid carcinoma 10.3 KRT7 KRT5
27 sensory organ benign neoplasm 10.3 KRT7 KRT5
28 peritoneum cancer 10.3 KRT7 KRT5
29 pericardial mesothelioma 10.3 KRT7 KRT10
30 breast myoepithelial neoplasm 10.2 KRT7 KRT5
31 lymphoepithelioma-like carcinoma 10.2 KRT7 KRT5
32 ileum cancer 10.2 KRT7 KRT10
33 nasal cavity squamous cell carcinoma 10.2 KRT7 KRT5
34 cystadenofibroma 10.2 KRT7 KRT5
35 lipoadenoma 10.2 KRT7 KRT5
36 breast secretory carcinoma 10.2 KRT7 KRT5
37 atypical choroid plexus papilloma 10.2 KRT7 KRT5
38 white sponge nevus 1 10.2 KRT7 KRT10
39 verrucous carcinoma 10.2 TP53 KRT10
40 anus cancer 10.2 KRT7 KRT5
41 keratinizing squamous cell carcinoma 10.2 TP53 KRT5
42 cystitis cystica 10.2 KRT7 KRT5
43 pinguecula 10.2 TP53 KRT10
44 bladder carcinoma in situ 10.1 TP53 KRT7
45 acanthoma 10.1 KRT17 KRT10
46 nasal cavity adenocarcinoma 10.1 TP53 KRT7
47 spindle cell carcinoma 10.1 KRT7 KRT5
48 papillary serous adenocarcinoma 10.1 TP53 KRT7
49 vulvar disease 10.1 TP53 KRT7
50 optic nerve neoplasm 10.1 TP53 KRT5

Graphical network of the top 20 diseases related to Eccrine Sweat Gland Neoplasm:



Diseases related to Eccrine Sweat Gland Neoplasm

Symptoms & Phenotypes for Eccrine Sweat Gland Neoplasm

MGI Mouse Phenotypes related to Eccrine Sweat Gland Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 KRT15 KRT17 KRT5 LUM TP53

Drugs & Therapeutics for Eccrine Sweat Gland Neoplasm

Search Clinical Trials , NIH Clinical Center for Eccrine Sweat Gland Neoplasm

Genetic Tests for Eccrine Sweat Gland Neoplasm

Anatomical Context for Eccrine Sweat Gland Neoplasm

MalaCards organs/tissues related to Eccrine Sweat Gland Neoplasm:

41
Skin

Publications for Eccrine Sweat Gland Neoplasm

Articles related to Eccrine Sweat Gland Neoplasm:

# Title Authors PMID Year
1
Malignant chondroid syringoma of the pinna. 38
26430319 2015
2
Primary mucinous carcinoma of the skin: the Mayo Clinic experience over the past 2 decades. 38
25627628 2015
3
A rare case of malignant chondroid syringoma of scalp. 38
23984246 2013
4
Aggressive digital papillary adenocarcinoma diagnosed by fine needle aspiration cytology. 38
21187879 2010
5
Aggressive digital papillary adenoma and adenocarcinoma. A clinicopathological study of 57 patients, with histochemical, immunopathological, and ultrastructural observations. 38
3301927 1987

Variations for Eccrine Sweat Gland Neoplasm

Expression for Eccrine Sweat Gland Neoplasm

Search GEO for disease gene expression data for Eccrine Sweat Gland Neoplasm.

Pathways for Eccrine Sweat Gland Neoplasm

Pathways related to Eccrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.93 KRT7 KRT5 KRT17 KRT15 KRT10
2 11.75 KRT7 KRT5 KRT17 KRT10
3
Show member pathways
11.48 KRT7 KRT5 KRT17 KRT15 KRT10
4
Show member pathways
11.47 KRT7 KRT5 KRT17
5 11.25 TP53 KRT5 KRT17

GO Terms for Eccrine Sweat Gland Neoplasm

Cellular components related to Eccrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.43 LUM KRT7 KRT5 KRT17 KRT15 KRT10
2 intermediate filament GO:0005882 9.02 KRT7 KRT5 KRT17 KRT15 KRT10

Biological processes related to Eccrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.35 KRT7 KRT5 KRT17 KRT15 KRT10
2 epidermis development GO:0008544 9.33 KRT5 KRT17 KRT15
3 cytoskeleton organization GO:0007010 9.26 KRT5 KRT15
4 cornification GO:0070268 9.02 KRT7 KRT5 KRT17 KRT15 KRT10

Molecular functions related to Eccrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 9.16 KRT5 KRT15
2 structural molecule activity GO:0005198 8.96 KRT17 KRT10
3 structural constituent of cytoskeleton GO:0005200 8.8 KRT5 KRT17 KRT15

Sources for Eccrine Sweat Gland Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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