MCID: ECC008
MIFTS: 28

Eccrine Sweat Gland Neoplasm

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Eccrine Sweat Gland Neoplasm

MalaCards integrated aliases for Eccrine Sweat Gland Neoplasm:

Name: Eccrine Sweat Gland Neoplasm 12 15
Malignant Eccrine Neoplasm 71
Eccrine Skin Neoplasm 12
Eccrine Neoplasm 71
Eccrine Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:173
NCIt 49 C6796
UMLS 71 C1333371 C1334577

Summaries for Eccrine Sweat Gland Neoplasm

MalaCards based summary : Eccrine Sweat Gland Neoplasm, also known as malignant eccrine neoplasm, is related to eccrine papillary adenoma and eccrine sweat gland cancer. An important gene associated with Eccrine Sweat Gland Neoplasm is CEACAM5 (CEA Cell Adhesion Molecule 5), and among its related pathways/superpathways are Developmental Biology and Relaxin signaling pathway. Affiliated tissues include skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Eccrine Sweat Gland Neoplasm

Diseases related to Eccrine Sweat Gland Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 305)
# Related Disease Score Top Affiliating Genes
1 eccrine papillary adenoma 31.8 PIP KRT17 KRT14 KRT10 CEACAM5
2 eccrine sweat gland cancer 30.9 PIP KRT7 KRT5 KRT19 KRT15 CLEC2A
3 syringoma 30.0 KRT7 KRT19 CLEC2A CEACAM5
4 spiradenoma 29.9 KRT7 KRT15 KRT14 CLEC2A
5 papillary adenocarcinoma 29.6 PIP KRT7 KRT19 CEACAM5
6 eccrine porocarcinoma 29.4 MAML2 KRT7 KRT5 KRT15 CEACAM5
7 clear cell hidradenoma 29.2 PIP MAML2 KRT7 KRT5 CLEC2A CEACAM5
8 hidradenoma 28.8 PIP MAML2 KRT7 KRT5 KRT15 CLEC2A
9 adenoid cystic carcinoma 28.7 KRT8 KRT7 KRT5 KRT19 KRT14
10 hidrocystoma 28.3 PIP KRT8 KRT7 KRT19 KRT15 CLEC2A
11 basal cell carcinoma 27.2 KRT8 KRT7 KRT5 KRT19 KRT17 KRT15
12 eccrine acrospiroma 25.8 PIP NUTM1 MAML2 KRT77 KRT7 KRT5
13 schopf-schulz-passarge syndrome 11.5
14 vulvar syringoma 10.5 PIP CEACAM5
15 fox-fordyce disease 10.5 PIP CEACAM5
16 vulvar eccrine porocarcinoma 10.5 PIP CEACAM5
17 leukoplakia of penis 10.5 KRT7 CEACAM5
18 urethral villous adenoma 10.5 KRT7 CEACAM5
19 clear cell acanthoma 10.5 KRT10 CLEC2A
20 pancreatic foamy gland adenocarcinoma 10.5 KRT7 CEACAM5
21 mucinous adenofibroma 10.5 KRT7 CEACAM5
22 urinary bladder villous adenoma 10.5 KRT7 CEACAM5
23 renal pelvis transitional cell carcinoma 10.4 KRT7 CLEC2A
24 mucoepidermoid esophageal carcinoma 10.4 KRT5 CEACAM5
25 cystitis cystica 10.4 KRT7 CEACAM5
26 mucinous intrahepatic cholangiocarcinoma 10.4 KRT7 CEACAM5
27 pancreatic serous cystadenocarcinoma 10.4 KRT7 CEACAM5
28 breast cystic hypersecretory carcinoma 10.4 KRT5 CEACAM5
29 vaginal tubulovillous adenoma 10.4 KRT7 CEACAM5
30 female urethral cancer 10.4 KRT7 CEACAM5
31 gallbladder squamous cell carcinoma 10.4 KRT5 CEACAM5
32 bile duct cystadenocarcinoma 10.4 KRT7 CEACAM5
33 mucinous ovarian cystadenoma 10.4 KRT7 CEACAM5
34 ovarian cystadenoma 10.4 KRT7 CEACAM5
35 anal canal paget's disease 10.4 PIP KRT7
36 bartholin's gland adenocarcinoma 10.4 PIP KRT7
37 rectosigmoid junction neoplasm 10.4 KRT7 CEACAM5
38 sigmoid neoplasm 10.4 KRT7 CEACAM5
39 gastric signet ring cell adenocarcinoma 10.4 PIP KRT7
40 krukenberg carcinoma 10.4 KRT7 CEACAM5
41 lipid-rich breast carcinoma 10.4 KRT5 CEACAM5
42 biliary papillomatosis 10.4 KRT7 CEACAM5
43 vulva basal cell carcinoma 10.4 KRT5 CEACAM5
44 adenoid basal cell carcinoma 10.4 KRT7 CEACAM5
45 transverse colon cancer 10.4 KRT7 CEACAM5
46 appendiceal neoplasm 10.4 KRT7 CEACAM5
47 colonic lymphangioma 10.4 KRT7 CEACAM5
48 bartholin's gland carcinoma 10.4 PIP KRT7
49 apocrine adenoma 10.4 PIP KRT7
50 appendix adenocarcinoma 10.4 KRT7 CEACAM5

Graphical network of the top 20 diseases related to Eccrine Sweat Gland Neoplasm:



Diseases related to Eccrine Sweat Gland Neoplasm

Symptoms & Phenotypes for Eccrine Sweat Gland Neoplasm

GenomeRNAi Phenotypes related to Eccrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.1 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-182 9.1 KRT5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-6 9.1 KRT8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.1 KRT5 KRT7 KRT8

MGI Mouse Phenotypes related to Eccrine Sweat Gland Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.17 KRT14 KRT15 KRT17 KRT19 KRT5 KRT8

Drugs & Therapeutics for Eccrine Sweat Gland Neoplasm

Search Clinical Trials , NIH Clinical Center for Eccrine Sweat Gland Neoplasm

Genetic Tests for Eccrine Sweat Gland Neoplasm

Anatomical Context for Eccrine Sweat Gland Neoplasm

MalaCards organs/tissues related to Eccrine Sweat Gland Neoplasm:

40
Skin

Publications for Eccrine Sweat Gland Neoplasm

Articles related to Eccrine Sweat Gland Neoplasm:

# Title Authors PMID Year
1
Malignant chondroid syringoma of the pinna. 61
26430319 2015
2
Primary mucinous carcinoma of the skin: the Mayo Clinic experience over the past 2 decades. 61
25627628 2015
3
A rare case of malignant chondroid syringoma of scalp. 61
23984246 2013
4
Aggressive digital papillary adenocarcinoma diagnosed by fine needle aspiration cytology. 61
21187879 2010
5
Aggressive digital papillary adenoma and adenocarcinoma. A clinicopathological study of 57 patients, with histochemical, immunopathological, and ultrastructural observations. 61
3301927 1987

Variations for Eccrine Sweat Gland Neoplasm

Expression for Eccrine Sweat Gland Neoplasm

Search GEO for disease gene expression data for Eccrine Sweat Gland Neoplasm.

Pathways for Eccrine Sweat Gland Neoplasm

Pathways related to Eccrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.19 KRT8 KRT77 KRT7 KRT5 KRT19 KRT17
2
Show member pathways
12.36 KRT19 KRT17 KRT15 KRT14 KRT10
3 12.22 KRT8 KRT7 KRT5 KRT19 KRT17 KRT10
4
Show member pathways
11.73 KRT8 KRT77 KRT7 KRT5 KRT19 KRT17
5 11.54 KRT19 KRT17 KRT15 KRT14 KRT10
6 11.49 KRT5 KRT17 KRT14
7
Show member pathways
11.47 KRT8 KRT7 KRT5 KRT19 KRT17 KRT14

GO Terms for Eccrine Sweat Gland Neoplasm

Cellular components related to Eccrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.85 PIP KRT8 KRT77 KRT7 KRT5 KRT19
2 cell periphery GO:0071944 9.56 KRT8 KRT19 KRT17 KRT14
3 apicolateral plasma membrane GO:0016327 9.4 KRT8 KRT19
4 costamere GO:0043034 9.37 KRT8 KRT19
5 keratin filament GO:0045095 9.35 KRT8 KRT77 KRT7 KRT5 KRT14
6 dystrophin-associated glycoprotein complex GO:0016010 9.32 KRT8 KRT19
7 intermediate filament GO:0005882 9.28 KRT8 KRT77 KRT7 KRT5 KRT19 KRT17

Biological processes related to Eccrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.61 KRT8 KRT77 KRT7 KRT5 KRT19 KRT17
2 epidermis development GO:0008544 9.5 KRT5 KRT15 KRT14
3 cornification GO:0070268 9.28 KRT8 KRT77 KRT7 KRT5 KRT19 KRT17
4 hemidesmosome assembly GO:0031581 9.26 KRT5 KRT14
5 cell differentiation involved in embryonic placenta development GO:0060706 9.16 KRT8 KRT19

Molecular functions related to Eccrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 9.33 KRT8 KRT5 KRT15
2 structural constituent of cytoskeleton GO:0005200 9.26 KRT5 KRT19 KRT15 KRT14
3 structural molecule activity GO:0005198 9.02 KRT19 KRT17 KRT15 KRT14 KRT10

Sources for Eccrine Sweat Gland Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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