MCID: ECH003
MIFTS: 56

Echinococcosis

Categories: Rare diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Echinococcosis

MalaCards integrated aliases for Echinococcosis:

Name: Echinococcosis 12 3 44 15 73
Hydatidosis 12 76 53
Echinococcosis, Pulmonary 73
Pulmonary Echinococcosis 12
Echinococcosis of Liver 12
Echinococcosis, Hepatic 73
Hepatic Echinococcosis 12
Echinococcal Disease 12
Liver Echinococcus 12
Hydatid Disease 12
Hydatids 55

Classifications:



External Ids:

Disease Ontology 12 DOID:1496
ICD10 33 B67 B67.90 B67.8
ICD9CM 35 122
MeSH 44 D004443
NCIt 50 C84682

Summaries for Echinococcosis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys.

MalaCards based summary : Echinococcosis, also known as hydatidosis, is related to alveolar echinococcosis and cystic echinococcosis. An important gene associated with Echinococcosis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Metronidazole and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain, and related phenotypes are hematopoietic system and immune system

CDC : 3 Echinococcosis is a parasitic disease caused by infection with tiny tapeworms of the genus Echinocococcus. Echinococcosis is classified as either cystic echinococcosis or alveolar echinococcosis.

Wikipedia : 76 Echinococcosis is a parasitic disease of tapeworms of the Echinococcus type. The two main types of the... more...

Related Diseases for Echinococcosis

Diseases related to Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 391)
# Related Disease Score Top Affiliating Genes
1 alveolar echinococcosis 33.1 CCL17 HLA-B HLA-DRB1 MT-CO1 TNF
2 cystic echinococcosis 30.5 CD40LG CES1 HLA-DRB1 IL10 IL17A MT-ATP6
3 cysticercosis 30.5 IL6 MT-CO1 MT-ND1
4 fascioliasis 30.4 IFNG IL10 MT-CO1
5 peritonitis 30.4 IL10 IL6 TNF
6 taeniasis 29.8 CD40LG CD79A MT-CO1 MT-ND1
7 prostatitis 29.8 IL10 IL6 TNF
8 myeloma, multiple 29.4 CD40LG CD79A IL6 TNF
9 cholangitis 29.1 CD40LG HLA-B HLA-DRB1 IL6 TNF
10 pneumonia 28.6 CD40LG IL10 IL5 IL6 TNF
11 colitis 28.4 IFNG IL10 IL17A IL6 TNF
12 toxoplasmosis 28.2 CD40LG CD79A IFNG IL10 IL6 TNF
13 arthritis 28.0 HLA-DRB1 IFNG IL10 IL17A IL6 TNF
14 schistosomiasis 28.0 CD40LG CD79A IFNG IL10 IL5 TNF
15 acquired immunodeficiency syndrome 27.8 CD40LG CD79A HLA-B IFNG IL10 IL6
16 rheumatoid arthritis 26.6 CD40LG CD79A HLA-B HLA-DRB1 IFNG IL10
17 malaria 25.9 CD40LG HLA-B HLA-DRB1 IFNG IL10 IL17A
18 polycystic echinococcosis 12.3
19 cardiac hydatid cysts with intracavitary expansion 11.9
20 postherpetic neuralgia 11.0 HLA-B HLA-DRB1
21 idiopathic inflammatory myopathy 10.9 HLA-B HLA-DRB1
22 selective igg deficiency disease 10.9 CD40LG CD79A
23 c1q nephropathy 10.9 CD40LG CD79A
24 juvenile myasthenia gravis 10.9 HLA-DRB1 IL10
25 meningovascular neurosyphilis 10.9 CD40LG CD79A
26 alpha chain disease 10.9 CD40LG CD79A
27 brill-zinsser disease 10.9 CD40LG CD79A
28 exudative glomerulonephritis 10.9 CD40LG CD79A
29 cork-handlers' disease 10.9 CD40LG CD79A
30 sideroblastic anemia acquired 10.9 MT-ATP6 MT-CO1
31 salpingo-oophoritis 10.9 CD40LG CD79A
32 early yaws 10.8 CD40LG CD79A
33 ventilation pneumonitis 10.8 CD40LG CD79A
34 chronic interstitial cystitis 10.8 CD40LG CD79A
35 axillary adenitis 10.8 CD40LG CD79A
36 cryofibrinogenemia 10.8 CD40LG CD79A
37 trichostrongyloidiasis 10.8 CD40LG CD79A
38 subacute bacterial endocarditis 10.8 CD40LG CD79A
39 heterophyiasis 10.8 CD40LG CD79A
40 immunoglobulin g deficiency 10.8 CD40LG CD79A
41 orbital granuloma 10.8 CD40LG CD79A
42 transient hypogammaglobulinemia of infancy 10.8 CD40LG CD79A
43 hyperglobulinemic purpura 10.8 CD40LG CD79A
44 gastroduodenitis 10.8 CD40LG CD79A
45 bacterial conjunctivitis 10.8 CD40LG CD79A
46 heavy chain disease 10.8 CD40LG CD79A
47 neuroschistosomiasis 10.8 CD79A IFNG
48 ophthalmia neonatorum 10.8 CD40LG CD79A
49 parotid disease 10.8 CD40LG CD79A
50 pemphigoid gestationis 10.8 HLA-DRB1 IL5

Graphical network of the top 20 diseases related to Echinococcosis:



Diseases related to Echinococcosis

Symptoms & Phenotypes for Echinococcosis

MGI Mouse Phenotypes related to Echinococcosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.91 IL5 IL6 CCL17 TNF CD40LG CD79A
2 immune system MP:0005387 9.85 IL6 MT-CO1 TNF CCL17 CD40LG CD79A
3 liver/biliary system MP:0005370 9.5 IL5 IL6 TNF CD79A CES1 IFNG
4 neoplasm MP:0002006 9.1 IL5 IL6 TNF CD79A IFNG IL10

Drugs & Therapeutics for Echinococcosis

Drugs for Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved 443-48-1 4173
2
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
3
Racepinephrine Approved Not Applicable 329-65-7 838
4
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
5
Mebendazole Approved, Vet_approved Not Applicable 31431-39-7 4030
6 Benzimidazole Experimental, Investigational ,Not Applicable 51-17-2
7 Liver Extracts Not Applicable
8 Antiparasitic Agents ,Not Applicable
9 Anthelmintics ,Not Applicable
10 Anti-Infective Agents ,Not Applicable
11 Coagulants Not Applicable
12 Epinephryl borate Not Applicable
13 Hemostatics Not Applicable
14 Antimitotic Agents Not Applicable
15 Antiprotozoal Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the Liver Completed NCT01643018 Not Applicable
2 Long-term Results of Comprehensive AE Management Completed NCT02509884
3 Epi Cystic Hydatid Disease Peru Completed NCT00138346
4 Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles Completed NCT00658294
5 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212 Not Applicable
6 MR Assessment of Hepatic Hydatid Disease Recruiting NCT03289884
7 Efficacy and Tolerability of Hemopatch After Hepatic Resection Recruiting NCT03323359 Not Applicable
8 Intestinal Parasites in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435
9 Alveolar Echinococcosis: Parasite Viability and Innovative Markers for the Follow-up of Patients Treated With Albendazole Active, not recruiting NCT02876146 Not Applicable Benzimidazole
10 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Echinococcosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: echinococcosis

Genetic Tests for Echinococcosis

Anatomical Context for Echinococcosis

MalaCards organs/tissues related to Echinococcosis:

41
Liver, Lung, Brain, Heart, Spleen, Testes, Kidney

Publications for Echinococcosis

Articles related to Echinococcosis:

(show top 50) (show all 1263)
# Title Authors Year
1
First description of Echinococcus ortleppi and cystic echinococcosis infection status in Chile. ( 29771992 )
2018
2
Major hepatectomies in liver cystic echinococcosis: A bi-centric experience. Retrospective cohort study. ( 29733994 )
2018
3
Prevalence of abdominal cystic echinococcosis in rural Bulgaria, Romania, and Turkey: a cross-sectional, ultrasound-based, population study from the HERACLES project. ( 29793823 )
2018
4
Seronegative alveolar echinococcosis in a patient with multiple myeloma. ( 29425710 )
2018
5
Cerebral cystic echinococcosis in Mongolian children caused by Echinococcus canadensis. ( 29753095 )
2018
6
Cystic echinococcosis in Turkana, Kenya: 30 years of imaging in an endemic region. ( 29155205 )
2018
7
Impact of affected lymph nodes on long-term outcome after surgical therapy of alveolar echinococcosis. ( 29909530 )
2018
8
Alveolar echinococcosis in the head of pancreas: A case report. ( 29538198 )
2018
9
MR imaging features of peritoneal alveolar echinococcosis. ( 29580747 )
2018
10
The Investigation of the Effect and Mechanism of <i>Sophora moorcroftiana</i> Alkaloids in Combination with Albendazole on Echinococcosis in an Experimental Rats Model. ( 29785189 )
2018
11
Human cystic echinococcosis in Hungary (2000-2014): a retrospective case series analysis from a single-center study. ( 29752648 )
2018
12
Plasma IL-23 and IL-5 as surrogate markers of lesion metabolic activity in patients with hepatic alveolar echinococcosis. ( 29535327 )
2018
13
Knowledge, attitudes and practices related to cystic echinococcosis endemicity in Pakistan. ( 29353554 )
2018
14
Management of cystic echinococcosis in the last two decades: what have we learned? ( 29897552 )
2018
15
Alveolar echinococcosis in a dog; analysis of clinical and histological findings and molecular identification of Echinococcus multilocularis. ( 29975636 )
2018
16
Cystic echinococcosis in animals and humans of Maharashtra State, India. ( 29654685 )
2018
17
Investigation of the Applicability of a Rapid Diagnosis Test in the Diagnosis of Cystic Echinococcosis. ( 29780006 )
2018
18
Single-center experience in the surgical treatment of combined lung Echinococcosis. ( 29332106 )
2018
19
Cystic echinococcosis in a domestic cat (Felis catus) in Italy. ( 29727269 )
2018
20
eComment. New horizons in diagnosing and managing cardiac echinococcosis. ( 29361169 )
2018
21
Seroprevalence of Human Cystic Echinococcosis in Alborz Province, Central Iran in 2015. ( 29900141 )
2018
22
In vitro and in vivo efficacies of carbazole aminoalcohols in the treatment of alveolar echinococcosis. ( 29746870 )
2018
23
Genotype characterization of livestock and human cystic echinococcosis in Mazandaran province, Iran. ( 29446344 )
2018
24
Design and construction of a new recombinant fusion protein (2b2t+EPC1) and its assessment for serodiagnosis of cystic echinococcosis. ( 29696723 )
2018
25
Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets. ( 29677189 )
2018
26
Alveolar echinococcosis in the liver of an adolescent boy. ( 29643103 )
2018
27
Cystic echinococcosis in marketed offal of sheep in Basrah, Iraq: Abattoir-based survey and a probabilistic model estimation of the direct economic losses due to hydatid cyst. ( 29774298 )
2018
28
Transjugular intrahepatic portosystemic shunt for alveolar echinococcosis of the liver and Budd-Chiari syndrome. ( 29891417 )
2018
29
Albendazole nanocrystals in experimental alveolar echinococcosis: Enhanced chemoprophylactic and clinical efficacy in infected mice. ( 29426481 )
2018
30
Performance of the commercially available SERION ELISA classic Echinococcus IgG test for the detection of cystic echinococcosis in clinical practice. ( 29950187 )
2018
31
Knowledge, Awareness and Practices Regarding Cystic Echinococcosis among Livestock Farmers in Basrah Province, Iraq. ( 29415425 )
2018
32
The seroprevalence rate and population genetic structure of human cystic echinococcosis in the Middle East: A systematic review and meta-analysis. ( 29367032 )
2018
33
The choose of different surgical therapies of hepatic alveolar echinococcosis: A single-center retrospective case-control study. ( 29465544 )
2018
34
Ageing impairs parasite-specific antibody responses in cystic echinococcosis. ( 29161459 )
2018
35
Removal notice for Liver autotransplantation and retrohepatic vena cava reconstruction for alveolar echinococcosis [JSR 210 (2017) 169-176]. ( 29433881 )
2018
36
Acute cholangitis complicating a chronic alveolar echinococcosis: an unusual therapeutic cholangioscopy. ( 29895060 )
2018
37
Cystic echinococcosis in Jordan: A review of causative species, previous studies, serological and radiological diagnosis. ( 29246408 )
2018
38
Field evaluation of an immunochromatographic test for diagnosis of cystic and alveolar echinococcosis. ( 29792228 )
2018
39
A Community-Based Study to Estimate the Seroprevalence of Trichinellosis and Echinococcosis in the Roma and Non-Roma Population of Slovakia. ( 29393919 )
2018
40
Computed Tomography Perfusion Imaging for the Diagnosis of Hepatic Alveolar Echinococcosis. ( 29531482 )
2018
41
Preliminary Evidence for the Absence of Cystic Echinococcosis in Gabon: A Cross-Sectional Pilot Survey in Humans and Definitive Hosts. ( 29785924 )
2018
42
Evaluation of kinase-inhibitors nilotinib and everolimus against alveolar echinococcosis inA vitro and in a mouse model. ( 29625098 )
2018
43
Liver transplantation for hepatic alveolar echinococcosis: literature review and three new cases. ( 29363377 )
2018
44
Hepatic alveolar echinococcosis. ( 29653501 )
2018
45
Cardio-abdominal echinococcosis: A man with a visible pulsating abdominal mass. ( 29318110 )
2018
46
Diffusion-Weighted MRI for the Initial Viability Evaluation of Parasites in Hepatic Alveolar Echinococcosis: Comparison with Positron Emission Tomography. ( 29353998 )
2018
47
A novel in silico minigene vaccine based on CD4<sup>+</sup>T-helper and B-cell epitopes of EG95 isolates for vaccination against cystic echinococcosis. ( 29195784 )
2018
48
Preliminary assessment of the diagnostic performances of a new rapid diagnostic test for the serodiagnosis of human cystic echinococcosis. ( 29776711 )
2018
49
In vitro study on protoscolicidal effect of methanolic extract of Allium hirtifolium on protoscoleces of cystic echinococcosis ( 29741144 )
2018
50
A retrospective study of human cystic echinococcosis in Basrah province, Iraq. ( 29183851 )
2018

Variations for Echinococcosis

Expression for Echinococcosis

Search GEO for disease gene expression data for Echinococcosis.

Pathways for Echinococcosis

Pathways related to Echinococcosis according to GeneCards Suite gene sharing:

(show all 46)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 CD40LG CD79A HLA-B HLA-DRB1 IFNG IL10
2
Show member pathways
13.63 CCL17 CD40LG IFNG IL10 IL17A IL5
3
Show member pathways
13.46 CCL17 IFNG IL10 IL17A IL5 IL6
4
Show member pathways
13.37 CCL17 CD40LG IL10 IL17A IL5 IL6
5
Show member pathways
13.29 CD40LG HLA-B HLA-DRB1 IFNG IL10 IL17A
6
Show member pathways
13.26 CCL17 CD40LG IL10 IL17A IL5 IL6
7
Show member pathways
12.76 HLA-B HLA-DRB1 IFNG IL6 TNF
8
Show member pathways
12.58 IFNG IL10 IL17A IL6 TNF
9
Show member pathways
12.57 HLA-B IFNG IL10 IL17A IL5 IL6
10
Show member pathways
12.55 CD40LG HLA-B HLA-DRB1 IFNG IL10 IL17A
11 12.54 CD40LG CD79A IFNG IL10 IL17A TNF
12 12.4 HLA-B HLA-DRB1 IL6 TNF
13
Show member pathways
12.37 HLA-DRB1 IFNG IL10 IL17A IL5 IL6
14
Show member pathways
12.3 CCL17 IFNG IL17A IL5 IL6 TNF
15 12.27 HLA-B HLA-DRB1 IFNG IL10
16
Show member pathways
12.27 IFNG IL10 IL17A IL6 TNF
17
Show member pathways
12.27 CD40LG IFNG IL10 IL17A IL5 IL6
18
Show member pathways
12.26 CD40LG HLA-DRB1 IFNG IL10 TNF
19 12.21 HLA-DRB1 IFNG IL10 IL6 TNF
20
Show member pathways
12.2 CCL17 IL10 IL6 TNF
21
Show member pathways
12.07 CCL17 IFNG IL10 IL17A IL5 IL6
22 11.99 IL10 IL17A IL6 TNF
23 11.95 IFNG IL6 TNF
24 11.91 HLA-DRB1 IL5 IL6 TNF
25 11.9 IFNG IL10 IL6 TNF
26 11.83 HLA-DRB1 IFNG IL17A IL6 TNF
27 11.8 CD79A IFNG IL10 IL5 IL6 TNF
28 11.79 IFNG IL5 IL6
29
Show member pathways
11.79 CD40LG IFNG IL5 TNF
30 11.78 IFNG IL10 IL6 TNF
31 11.76 IFNG IL10 IL17A IL5 TNF
32 11.74 IL10 IL6 TNF
33 11.68 CCL17 CD40LG IL10 IL5
34
Show member pathways
11.67 CD40LG IFNG IL6 TNF
35 11.65 IL5 IL6 TNF
36 11.55 IFNG IL6 TNF
37 11.53 IL10 IL6 TNF
38 11.5 CCL17 IFNG IL10 IL5
39 11.48 IFNG IL6 TNF
40 11.46 CD40LG IFNG IL10 IL6 TNF
41 11.36 IL10 IL6 TNF
42 11.36 IFNG IL10 IL6 TNF
43 11.33 CD40LG IFNG IL5
44 11.22 IFNG IL10 IL5
45 10.86 IFNG IL17A IL5 IL6 TNF
46 10.58 HLA-DRB1 IFNG IL10 IL5 IL6 TNF

GO Terms for Echinococcosis

Cellular components related to Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 CCL17 CD40LG IFNG IL10 IL17A IL5
2 external side of plasma membrane GO:0009897 9.35 CD40LG CD79A HLA-DRB1 IL17A TNF
3 extracellular space GO:0005615 9.28 CCL17 CD40LG CES1 IFNG IL10 IL17A

Biological processes related to Echinococcosis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.8 IL10 IL17A IL5 IL6 TNF
2 B cell differentiation GO:0030183 9.74 CD40LG CD79A IL10
3 interferon-gamma-mediated signaling pathway GO:0060333 9.73 HLA-B HLA-DRB1 IFNG
4 response to glucocorticoid GO:0051384 9.72 IL10 IL6 TNF
5 humoral immune response GO:0006959 9.7 IFNG IL6 TNF
6 inflammatory response GO:0006954 9.7 CCL17 CD40LG IL10 IL17A IL5 IL6
7 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 IFNG TNF
8 positive regulation of DNA binding transcription factor activity GO:0051091 9.62 IL10 IL5 IL6 TNF
9 negative regulation of growth of symbiont in host GO:0044130 9.61 IL10 TNF
10 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL10 TNF
11 B cell proliferation GO:0042100 9.61 CD40LG CD79A IL10
12 positive regulation of immunoglobulin secretion GO:0051024 9.6 IL5 IL6
13 positive regulation of podosome assembly GO:0071803 9.59 IL5 TNF
14 negative regulation of lipid storage GO:0010888 9.58 IL6 TNF
15 endothelial cell apoptotic process GO:0072577 9.58 IL10 TNF
16 regulation of signaling receptor activity GO:0010469 9.56 CCL17 CD40LG IFNG IL10 IL17A IL5
17 negative regulation of cytokine secretion involved in immune response GO:0002740 9.54 IL10 TNF
18 positive regulation of interleukin-23 production GO:0032747 9.51 IFNG IL17A
19 regulation of immunoglobulin secretion GO:0051023 9.49 CD40LG TNF
20 receptor biosynthetic process GO:0032800 9.48 IL10 TNF
21 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.46 IFNG TNF
22 positive regulation of osteoclast differentiation GO:0045672 9.43 IFNG IL17A TNF
23 positive regulation of vitamin D biosynthetic process GO:0060557 9.37 IFNG TNF
24 immune response GO:0006955 9.32 CCL17 CD40LG HLA-B HLA-DRB1 IFNG IL10

Molecular functions related to Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 CCL17 CD40LG IFNG IL10 IL17A IL5

Sources for Echinococcosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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