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MCID: ECH003
MIFTS: 59

Echinococcosis

Categories: Infectious diseases, Liver diseases, Neuronal diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Echinococcosis

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MalaCards integrated aliases for Echinococcosis:

Name: Echinococcosis 12 45 15 17 74 3
Hydatidosis 12 77 54 15
Echinococcosis, Pulmonary 74
Pulmonary Echinococcosis 12
Echinococcosis of Liver 12
Echinococcosis, Hepatic 74
Hepatic Echinococcosis 12
Echinococcal Disease 12
Liver Echinococcus 12
Hydatid Disease 12
Hydatids 56

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Neuronal diseases Respiratory diseases Liver diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:1496
ICD9CM 36 122
MeSH 45 D004443
NCIt 51 C84682
SNOMED-CT 69 74942003
ICD10 34 B67 B67.8 B67.90
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Summaries for Echinococcosis

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Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys.

MalaCards based summary : Echinococcosis, also known as hydatidosis, is related to alveolar echinococcosis and cystic echinococcosis. An important gene associated with Echinococcosis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Metronidazole and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

CDC : 3 Echinococcosis is a parasitic disease caused by infection with tiny tapeworms of the genus Echinocococcus. Echinococcosis is classified as either cystic echinococcosis or alveolar echinococcosis.

Wikipedia : 77 Echinococcosis is a parasitic disease of tapeworms of the Echinococcus type. The two main types of the... more...

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Related Diseases for Echinococcosis

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Diseases related to Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 536)
# Related Disease Score Top Affiliating Genes
1 alveolar echinococcosis 33.4 CCL17 HLA-B HLA-DRB1 KLRK1 MT-CO1 TLR4
2 cystic echinococcosis 32.3 CES1 HLA-DRB1 IL10 IL17A IL6 MT-ATP6
3 cysticercosis 31.2 IL6 MT-CO1 TLR4
4 taeniasis 30.5 IL10 MT-CO1 MT-ND1
5 pericarditis 30.2 IFNG IL6 TNF
6 cholangitis 30.2 HLA-B HLA-DRB1 IL6 TNF
7 sclerosing cholangitis 30.2 HLA-B HLA-DRB1 TNF
8 endocarditis 30.1 IL10 IL6 TNF
9 peritonitis 30.1 IL10 IL6 TNF
10 coenurosis 30.0 MT-CO1 MT-ND1
11 cystitis 29.9 IL6 TLR4 TNF
12 toxoplasmosis 29.9 IFNG IL10 IL6 TLR4 TNF
13 appendicitis 29.8 IL10 IL6 TNF
14 paragonimiasis 29.8 CCL17 IL5 MT-CO1
15 brucellosis 29.7 IFNG IL10 IL6 TLR4 TNF
16 myelitis 29.7 IL17A IL6 TNF
17 meningitis 29.6 IFNG IL10 IL6 TNF
18 schistosomiasis 29.6 IFNG IL10 IL5 TNF
19 pneumonia 29.6 IL10 IL5 IL6 TLR4 TNF
20 osteomyelitis 29.6 IFNG IL10 IL6 TNF
21 q fever 29.5 IFNG IL10 IL6 TLR4 TNF
22 acquired immunodeficiency syndrome 29.5 HLA-B IFNG IL10 IL6 TNF
23 parasitic protozoa infectious disease 29.5 IFNG IL10 IL6 MT-CO1 TNF
24 lung disease 29.4 IL10 IL17A IL5 IL6 TNF
25 leishmaniasis 29.3 HLA-DRB1 IFNG IL10 IL5 TLR4 TNF
26 human immunodeficiency virus type 1 29.3 HLA-B IFNG IL10 IL6 TNF
27 filariasis 29.2 IFNG IL10 IL5 IL6 TLR4 TNF
28 arthritis 29.2 HLA-DRB1 IFNG IL10 IL17A IL6 TNF
29 colitis 29.1 IFNG IL10 IL17A IL6 TLR4 TNF
30 aspergillosis 29.0 CCL17 IFNG IL10 IL5 TLR4 TNF
31 rheumatoid arthritis 28.8 HLA-B HLA-DRB1 IFNG IL10 IL17A IL6
32 malaria 28.3 HLA-B HLA-DRB1 IFNG IL10 IL17A IL5
33 polycystic echinococcosis 12.5
34 cardiac hydatid cysts with intracavitary expansion 11.5
35 hydatidiform mole, recurrent, 1 11.4
36 partial hydatidiform mole 11.1
37 pars planitis 10.5 HLA-B HLA-DRB1
38 idiopathic inflammatory myopathy 10.5 HLA-B HLA-DRB1
39 postherpetic neuralgia 10.5 HLA-B HLA-DRB1
40 anca-associated vasculitis 10.5 HLA-DRB1 IL6
41 juvenile myasthenia gravis 10.5 HLA-DRB1 IL10
42 pemphigoid gestationis 10.5 HLA-DRB1 IL5
43 pouchitis 10.5 IL10 TLR4
44 eye lymphoma 10.5 IL10 IL6
45 microscopic polyangiitis 10.5 HLA-DRB1 TNF
46 trench fever 10.5 TLR4 TNF
47 bagassosis 10.5 IL5 IL6
48 acute transverse myelitis 10.5 IL10 IL6
49 drug reaction with eosinophilia and systemic symptoms 10.5 HLA-B TNF
50 berylliosis 10.5 HLA-DRB1 IFNG

Graphical network of the top 20 diseases related to Echinococcosis:



Diseases related to Echinococcosis
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Symptoms & Phenotypes for Echinococcosis

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GenomeRNAi Phenotypes related to Echinococcosis according to GeneCards Suite gene sharing:

27 (show all 26)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.81 IL10 UBR5
2 Increased shRNA abundance (Z-score > 2) GR00366-A-106 9.81 UBR5
3 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.81 IL10
4 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.81 HLA-DRB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.81 IL10
6 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.81 HLA-DRB1 IL10
7 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.81 IL10
8 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.81 HLA-DRB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.81 IL10
10 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.81 IL10
11 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.81 HLA-DRB1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.81 HLA-DRB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.81 HLA-DRB1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.81 HLA-DRB1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.81 IL10
16 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.81 IL10
17 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.81 IL10
18 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.81 IL10
19 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.81 UBR5
20 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.81 IL10
21 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.81 UBR5
22 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.81 IL10
23 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.81 IL10 UBR5
24 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.81 HLA-DRB1 IL10 UBR5
25 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.81 IL10
26 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.81 IL10

MGI Mouse Phenotypes related to Echinococcosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.8 IFNG IL10 IL17A IL5 IL6 TLR4
2 liver/biliary system MP:0005370 9.7 CES1 IFNG IL10 IL5 IL6 TLR4
3 neoplasm MP:0002006 9.43 IFNG IL10 IL5 IL6 TLR4 TNF
4 respiratory system MP:0005388 9.17 IFNG IL10 IL17A IL5 IL6 TLR4
Sources

Drugs & Therapeutics for Echinococcosis

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Drugs for Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved 443-48-1 4173
2
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
3
Racepinephrine Approved Not Applicable 329-65-7 838
4
Iodine Approved, Investigational 7553-56-2 807
5
Mebendazole Approved, Vet_approved Not Applicable 31431-39-7 4030
6
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
7 Benzimidazole Experimental, Investigational ,Not Applicable 51-17-2
8 Liver Extracts Not Applicable
9 Antiparasitic Agents ,Not Applicable
10 Anthelmintics ,Not Applicable
11 Anti-Infective Agents ,Not Applicable
12 Hemostatics Not Applicable
13 Epinephryl borate Not Applicable
14 Coagulants Not Applicable
15 cadexomer iodine
16 Antimitotic Agents Not Applicable
17 Antiprotozoal Agents Not Applicable

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Periprosthetic Fracture Following Tibial Echinococcosis Completed NCT03622346 Not Applicable
2 Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the Liver Completed NCT01643018 Not Applicable
3 Long-term Results of Comprehensive AE Management Completed NCT02509884
4 Epi Cystic Hydatid Disease Peru Completed NCT00138346
5 Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles Completed NCT00658294
6 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212 Not Applicable
7 MR Assessment of Hepatic Hydatid Disease Recruiting NCT03289884
8 Efficacy and Tolerability of Hemopatch After Hepatic Resection Recruiting NCT03323359 Not Applicable
9 Intestinal Parasites in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435
10 Alveolar Echinococcosis: Parasite Viability and Innovative Markers for the Follow-up of Patients Treated With Albendazole Active, not recruiting NCT02876146 Not Applicable Benzimidazole
11 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Echinococcosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: echinococcosis

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Genetic Tests for Echinococcosis

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Anatomical Context for Echinococcosis

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MalaCards organs/tissues related to Echinococcosis:

42
Liver, Lung, Testes, Brain, Heart, Spleen, Kidney
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Publications for Echinococcosis

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Articles related to Echinococcosis:

(show top 50) (show all 2879)
# Title Authors Year
1
Vena cava inferior thrombosis in the course of advanced alveolar echinococcosis. ( 30608061 )
2019
2
Psychological burden and resilience factors in patients with Alveolar Echinococcosis - A cross-sectional study. ( 30615695 )
2019
3
The role of contrast-enhanced ultrasound in the diagnosis of hepatic alveolar echinococcosis. ( 30702614 )
2019
4
Is ex vivo liver resection and autotransplantation a valid alternative treatment for end-stage hepatic alveolar echinococcosis in Europe? ( 30718093 )
2019
5
Isolated Cerebral Alveolar Echinococcosis. ( 30740467 )
2019
6
Hunting Poses Only a Low Risk for Alveolar Echinococcosis. ( 30761283 )
2019
7
Outcomes of different surgical resection techniques for end-stage hepatic alveolar echinococcosis with inferior vena cava invasion. ( 30782476 )
2019
8
Doughnut sign of hepatic alveolar echinococcosis on FDG PET/CT: Clinical case report. ( 30813170 )
2019
9
FDG-PET/MRI Imaging for the Management of Alveolar Echinococcosis: Initial Clinical Experience at a Reference Centre in Austria. ( 30851233 )
2019
10
Closing the Brief Case: Incidental Finding of Cystic Echinococcosis during Evaluation for Hepatitis. ( 30814305 )
2019
11
Multi-Epitope Fusion Protein Eg mefAg-1 as a Serodiagnostic Candidate for Cystic Echinococcosis in Sheep. ( 30840802 )
2019
12
Progress towards international adoption of the World Health Organization ultrasound classification of cystic echinococcosis. ( 30267658 )
2019
13
Should Pediatricians Be Aware of Cystic Echinococcosis? A Literature Review. ( 30334932 )
2019
14
An immunocompromised patient & multiorgan cystic echinococcosis. ( 30605541 )
2019
15
Differentiation between hepatic cystic echinococcosis types 1 and simple hepatic cysts: A retrospective analysis. ( 30608385 )
2019
16
Neglected Zoonoses and the Missing Opportunities for One Health Education: The Case of Cystic Echinococcosis among Surgically Operated Patients in Basrah, Southern Iraq. ( 30621078 )
2019
17
Spinal Cystic Echinococcosis. ( 30652663 )
2019
18
Community perception and knowledge of cystic echinococcosis in the High Atlas Mountains, Morocco. ( 30691432 )
2019
19
Cystic Echinococcosis of the Bone: A European Multicenter Study. ( 30693857 )
2019
20
Evaluation of direct costs associated with alveolar and cystic echinococcosis in Austria. ( 30703091 )
2019
21
Cystic echinococcosis in unaccompanied minor refugees from Afghanistan and the Middle East to Germany, July 2016 through June 2017. ( 30739267 )
2019
22
Osseous cystic echinococcosis. A case series study at a referral unit in Spain. ( 30779741 )
2019
23
Risk Factors for Human Cystic Echinococcosis in Latvia. ( 30801230 )
2019
24
The Brief Case: Incidental Finding of Cystic Echinococcosis during Evaluation for Hepatitis. ( 30814304 )
2019
25
Effect of anacardic acid against echinococcosis through inhibition of VEGF-induced angiogenesis. ( 30642401 )
2019
26
Disseminated echinococcosis with pulmonary artery embolisation. ( 30672578 )
2019
27
SonoVue® Does Not Appear to Cross the Placenta as Observed During an Examination Aimed at Confirming a Diagnosis of Liver Echinococcosis in a Pregnant Woman. ( 30731478 )
2019
28
Echinococcosis: Advances in the 21st Century. ( 30760475 )
2019
29
Hodgkin's lymphoma, nephrotic syndrome, and echinococcosis cysts: an unusual association and literature review. ( 30784346 )
2019
30
Knowledge Domain and Emerging Trends on Echinococcosis Research: A Scientometric Analysis. ( 30857143 )
2019
31
Case Report: Rare Presentation of Multivisceral Echinococcosis. ( 30860020 )
2019
32
Laparoscopic cystectomy for pancreatic echinococcosis: A case report and literature review. ( 30863816 )
2019
33
Cystic lung lesions mimicking hydatidosis: hamartoma or benign metastazing leiomyoma? ( 30825451 )
2019
34
Hydatidosis in slaughtered sheep and goats in India: prevalence, genotypic characterization and pathological studies. ( 30702050 )
2019
35
Primary hydatidosis of distal femur masquerading malignancy -A rare case. ( 30705562 )
2019
36
Pattern of Relapse in Hepatic Hydatidosis: Analysis of 238 Cases in a Single Hospital. ( 30809783 )
2019
37
Expansion of a highly sensitive and specific ELISA test for diagnosis of hydatidosis using recombinant EgB8/2 protein. ( 30834077 )
2019
38
Comparison of Laparoscopic and Conventional Cystotomy/Partial Cystectomy in Treatment of Liver Hydatidosis. ( 30868067 )
2019
39
First description of Echinococcus ortleppi and cystic echinococcosis infection status in Chile. ( 29771992 )
2018
40
Major hepatectomies in liver cystic echinococcosis: A bi-centric experience. Retrospective cohort study. ( 29733994 )
2018
41
Prevalence of abdominal cystic echinococcosis in rural Bulgaria, Romania, and Turkey: a cross-sectional, ultrasound-based, population study from the HERACLES project. ( 29793823 )
2018
42
Seronegative alveolar echinococcosis in a patient with multiple myeloma. ( 29425710 )
2018
43
Cerebral cystic echinococcosis in Mongolian children caused by Echinococcus canadensis. ( 29753095 )
2018
44
Cystic echinococcosis in Turkana, Kenya: 30 years of imaging in an endemic region. ( 29155205 )
2018
45
Impact of affected lymph nodes on long-term outcome after surgical therapy of alveolar echinococcosis. ( 29909530 )
2018
46
Alveolar echinococcosis in the head of pancreas: A case report. ( 29538198 )
2018
47
MR imaging features of peritoneal alveolar echinococcosis. ( 29580747 )
2018
48
The Investigation of the Effect and Mechanism of <i>Sophora moorcroftiana</i> Alkaloids in Combination with Albendazole on Echinococcosis in an Experimental Rats Model. ( 29785189 )
2018
49
Human cystic echinococcosis in Hungary (2000-2014): a retrospective case series analysis from a single-center study. ( 29752648 )
2018
50
Plasma IL-23 and IL-5 as surrogate markers of lesion metabolic activity in patients with hepatic alveolar echinococcosis. ( 29535327 )
2018
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Variations for Echinococcosis

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Expression for Echinococcosis

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Search GEO for disease gene expression data for Echinococcosis.
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Pathways for Echinococcosis

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Pathways related to Echinococcosis according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 14 HLA-B HLA-DRB1 IFNG IL10 IL17A IL5
2
PEDF Induced Signaling 65
Show member pathways
 13.65 CCL17 IFNG IL10 IL17A IL5 IL6
3
TGF-Beta Pathway 65
Show member pathways
 13.51 CCL17 IFNG IL10 IL17A IL5 IL6
4
Akt Signaling 65
Show member pathways
 13.38 CCL17 IL10 IL17A IL5 IL6 TLR4
5
Cytokine Signaling in Immune system 67
Show member pathways
 13.33 HLA-B HLA-DRB1 IFNG IL10 IL17A IL5
6
PAK Pathway 65
Show member pathways
 13.26 CCL17 IL10 IL17A IL5 IL6 TNF
7
Toll-like Receptor Signaling Pathway 38 1
Show member pathways
 13.15 IFNG IL10 IL6 TLR4 TNF
8
Allograft rejection 1 38
Show member pathways
 12.87 HLA-B HLA-DRB1 IFNG IL10 IL17A IL5
9
Immune response IL-23 signaling pathway 23
Show member pathways
 12.59 IFNG IL10 IL17A IL6 TNF
10
Influenza A 38
Show member pathways
 12.58 HLA-B HLA-DRB1 IFNG IL6 TLR4 TNF
11
NF-kappaB Signaling 4
12.54 IFNG IL10 IL17A TNF
12
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 12.49 HLA-B IFNG KLRK1 TNF
13
T cell receptor signaling pathway 38
Show member pathways
 12.46 IFNG IL10 IL17A IL5 IL6 TNF
14
Th17 cell differentiation 38
Show member pathways
 12.46 HLA-DRB1 IFNG IL10 IL17A IL5 IL6
15
JAK-STAT signaling pathway (KEGG) 66
Show member pathways
 12.38 IFNG IL10 IL5 IL6
16
IL-17 Family Signaling Pathways 66
Show member pathways
 12.35 CCL17 IFNG IL17A IL5 IL6 TNF
17
Human T-cell leukemia virus 1 infection 38
12.34 HLA-B HLA-DRB1 IL6 TNF
18
Toll Comparative Pathway 65
Show member pathways
 12.3 IFNG IL6 TLR4 TNF
19
Toxoplasmosis 38
Show member pathways
 12.27 HLA-DRB1 IFNG IL10 TLR4 TNF
20
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.23 HLA-B IFNG IL10 IL17A IL5 IL6
21
Tuberculosis 38
12.22 HLA-DRB1 IFNG IL10 IL6 TLR4 TNF
22
C-type lectin receptor signaling pathway 38
Show member pathways
 12.21 CCL17 IL10 IL6 TNF
23
Bacterial infections in CF airways 23
Show member pathways
 12.18 IFNG IL6 TLR4 TNF
24
Colorectal Cancer Metastasis 65
12.18 IFNG IL6 TLR4 TNF
25
Immune response IFN gamma signaling pathway 23
Show member pathways
 12.08 CCL17 IFNG IL10 IL17A IL5 IL6
26
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 12.05 IFNG IL6 TLR4 TNF
27
Th1 Differentiation Pathway 66
Show member pathways
 12.05 IFNG IL10 IL17A IL6 TLR4 TNF
28
Spinal Cord Injury 1
12.03 IFNG IL6 TLR4 TNF
29
Interleukin-4 and 13 signaling 67
12 IL10 IL17A IL6 TNF
30
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.97 IFNG IL10 IL5 IL6 KLRK1 TNF
31
Amoebiasis 38
11.93 IFNG IL10 IL6 TLR4 TNF
32
Hematopoietic cell lineage 38
11.92 HLA-DRB1 IL5 IL6 TNF
33
HIF-1 signaling pathway 38
11.89 IFNG IL6 TLR4
34
Cytokine production by Th17 cells in CF (Mouse model) 23
Show member pathways
 11.86 IL17A IL6 TLR4
35
Jak-Stat Signaling Pathway (sino) 68
11.85 IFNG IL10 IL6
36
Rheumatoid arthritis 38
11.84 HLA-DRB1 IFNG IL17A IL6 TLR4 TNF
37
Salmonella infection (KEGG) 38
11.82 IFNG IL6 TLR4
38
Glucocorticoid receptor regulatory network 1
11.79 IFNG IL5 IL6
39
Pertussis 38
11.79 IL10 IL6 TLR4 TNF
40
Dendritic Cells Developmental Lineage Pathway 66
11.78 IFNG IL10 IL6 TNF
41
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.75 IFNG IL5 TNF
42
IL4-mediated signaling events 1
11.67 CCL17 IL10 IL5
43
Lung fibrosis 1
11.66 IL5 IL6 TNF
44
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.66 IFNG IL6 TNF
45
Innate Lymphoid Cell Differentiation Pathways 66
11.64 IFNG IL10 IL17A IL5 KLRK1 TNF
46
Legionellosis 38
11.6 IL6 TLR4 TNF
47
Photodynamic therapy-induced AP-1 survival signaling. 1
11.56 IFNG IL6 TNF
48
Th2 Differentiation Pathway 66
11.55 CCL17 IFNG IL10 IL5
49
Interleukin-10 signaling 67
11.54 IL10 IL6 TNF
50
MSP-RON Signaling 65
11.53 IFNG TLR4 TNF
Sources

GO Terms for Echinococcosis

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Cellular components related to Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 CCL17 CES1 IFNG IL10 IL17A IL5
2 cell surface GO:0009986 9.55 HLA-B HLA-DRB1 KLRK1 TLR4 TNF
3 external side of plasma membrane GO:0009897 9.02 HLA-DRB1 IL17A KLRK1 TLR4 TNF

Biological processes related to Echinococcosis according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.97 IFNG IL6 TLR4 TNF UBR5
2 cytokine-mediated signaling pathway GO:0019221 9.88 IL10 IL17A IL5 IL6 TNF
3 defense response to Gram-positive bacterium GO:0050830 9.83 IL6 KLRK1 TNF
4 interferon-gamma-mediated signaling pathway GO:0060333 9.79 HLA-B HLA-DRB1 IFNG
5 response to glucocorticoid GO:0051384 9.79 IL10 IL6 TNF
6 positive regulation of interleukin-6 production GO:0032755 9.77 IL6 TLR4 TNF
7 humoral immune response GO:0006959 9.77 IFNG IL6 TNF
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.73 IL10 IL5 IL6 TNF
9 positive regulation of interferon-gamma production GO:0032729 9.72 KLRK1 TLR4 TNF
10 cellular response to lipopolysaccharide GO:0071222 9.72 IL10 IL6 KLRK1 TLR4 TNF
11 regulation of signaling receptor activity GO:0010469 9.7 CCL17 IFNG IL10 IL17A IL5 IL6
12 negative regulation of interferon-gamma production GO:0032689 9.69 HLA-DRB1 IL10 TLR4
13 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.68 IL17A TLR4
14 positive regulation of glial cell proliferation GO:0060252 9.68 IL6 TNF
15 positive regulation of macrophage activation GO:0043032 9.67 IL10 TLR4
16 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.67 IFNG TNF
17 negative regulation of growth of symbiont in host GO:0044130 9.67 IL10 TNF
18 negative regulation of interleukin-6 production GO:0032715 9.67 IL10 TLR4 TNF
19 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.66 IL10 TNF
20 negative regulation of interleukin-17 production GO:0032700 9.65 IFNG TLR4
21 positive regulation of immunoglobulin secretion GO:0051024 9.65 IL5 IL6
22 positive regulation of podosome assembly GO:0071803 9.65 IL5 TNF
23 positive regulation of protein import into nucleus, translocation GO:0033160 9.64 IFNG UBR5
24 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.64 TLR4 TNF
25 T-helper 1 type immune response GO:0042088 9.63 HLA-DRB1 TLR4
26 negative regulation of lipid storage GO:0010888 9.63 IL6 TNF
27 endothelial cell apoptotic process GO:0072577 9.62 IL10 TNF
28 positive regulation of MHC class II biosynthetic process GO:0045348 9.61 IL10 TLR4
29 negative regulation of cytokine secretion involved in immune response GO:0002740 9.58 IL10 TNF
30 positive regulation of neuroinflammatory response GO:0150078 9.58 IL6 TNF
31 positive regulation of osteoclast differentiation GO:0045672 9.58 IFNG IL17A TNF
32 positive regulation of interleukin-23 production GO:0032747 9.56 IFNG IL17A
33 positive regulation of nitric oxide biosynthetic process GO:0045429 9.56 IFNG KLRK1 TLR4 TNF
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 IFNG TNF
35 positive regulation of chemokine production GO:0032722 9.54 IL6 TLR4 TNF
36 receptor biosynthetic process GO:0032800 9.52 IL10 TNF
37 inflammatory response GO:0006954 9.5 CCL17 IL10 IL17A IL5 IL6 TLR4
38 positive regulation of vitamin D biosynthetic process GO:0060557 9.46 IFNG TNF
39 immune response GO:0006955 9.32 CCL17 HLA-B HLA-DRB1 IFNG IL10 IL17A

Molecular functions related to Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CCL17 IFNG IL10 IL17A IL5 IL6
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Sources for Echinococcosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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