Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: ECH003
MIFTS: 59

Echinococcosis

Categories: Infectious diseases, Liver diseases, Neuronal diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Echinococcosis

About this section

MalaCards integrated aliases for Echinococcosis:

Name: Echinococcosis 12 3 44 15 73
Hydatidosis 12 76 53 15
Echinococcosis, Pulmonary 73
Pulmonary Echinococcosis 12
Echinococcosis of Liver 12
Echinococcosis, Hepatic 73
Hepatic Echinococcosis 12
Echinococcal Disease 12
Liver Echinococcus 12
Hydatid Disease 12
Hydatids 55

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Neuronal diseases Respiratory diseases Liver diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1496
ICD10 33 B67 B67.90 B67.8
ICD9CM 35 122
MeSH 44 D004443
NCIt 50 C84682
SNOMED-CT 68 74942003
Sources

Summaries for Echinococcosis

About this section
Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys.

MalaCards based summary : Echinococcosis, also known as hydatidosis, is related to alveolar echinococcosis and cystic echinococcosis. An important gene associated with Echinococcosis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Metronidazole and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and brain, and related phenotypes are homeostasis/metabolism and hematopoietic system

CDC : 3 Echinococcosis is a parasitic disease caused by infection with tiny tapeworms of the genus Echinocococcus. Echinococcosis is classified as either cystic echinococcosis or alveolar echinococcosis.

Wikipedia : 76 Echinococcosis is a parasitic disease of tapeworms of the Echinococcus type. The two main types of the... more...

Sources

Related Diseases for Echinococcosis

About this section

Diseases related to Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 515)
# Related Disease Score Top Affiliating Genes
1 alveolar echinococcosis 33.7 CCL17 HLA-B HLA-DRB1 MT-CO1 TLR2 TLR4
2 cystic echinococcosis 32.9 CES1 HLA-DRB1 IL10 IL17A IL6 MT-ATP6
3 cysticercosis 30.9 IL6 MT-CO1 TLR4
4 taeniasis 30.4 IL10 MT-CO1 MT-ND1
5 pericarditis 30.0 IFNG IL6 TNF
6 sclerosing cholangitis 30.0 HLA-B HLA-DRB1 TNF
7 infective endocarditis 29.9 IL6 TLR2 TNF
8 invasive aspergillosis 29.8 IFNG TLR2 TLR4
9 coenurosis 29.8 MT-CO1 MT-ND1
10 cholangitis 29.7 HLA-B HLA-DRB1 IL6 TNF
11 brucellosis 29.7 IFNG IL10 IL6 TLR4 TNF
12 cystitis 29.7 IL6 TLR4 TNF
13 toxoplasmosis 29.7 IFNG IL10 IL6 TLR2 TLR4 TNF
14 mastitis 29.7 IL17A IL6 TLR2
15 appendicitis 29.7 IL10 IL6 TNF
16 endocarditis 29.7 IL10 IL6 TLR2 TNF
17 paragonimiasis 29.6 CCL17 IL5 MT-CO1
18 human immunodeficiency virus type 1 29.6 HLA-B IFNG IL10 IL6 TNF
19 acquired immunodeficiency syndrome 29.5 HLA-B IFNG IL10 IL6 TNF
20 viral infectious disease 29.5 IFNG IL10 IL6 TNF
21 osteomyelitis 29.5 IFNG IL10 IL6 TNF
22 meningitis 29.5 IFNG IL10 IL6 TLR2 TNF
23 schistosomiasis 29.5 IFNG IL10 IL5 TNF
24 q fever 29.4 IFNG IL10 IL6 TLR2 TLR4 TNF
25 parasitic protozoa infectious disease 29.3 IFNG IL10 IL6 MT-CO1 TLR2 TNF
26 pneumonia 29.3 IL10 IL5 IL6 TLR2 TLR4 TNF
27 arthritis 29.3 HLA-DRB1 IFNG IL10 IL17A IL6 TNF
28 colitis 29.3 IFNG IL10 IL17A IL6 TLR4 TNF
29 lung disease 29.1 IL10 IL17A IL5 IL6 TLR2 TNF
30 aspergillosis 29.1 CCL17 IFNG IL10 IL5 TLR2 TLR4
31 rheumatoid arthritis 28.8 HLA-B HLA-DRB1 IFNG IL10 IL17A IL6
32 leishmaniasis 28.7 HLA-DRB1 IFNG IL10 IL17A IL5 IL6
33 malaria 28.4 HLA-B HLA-DRB1 IFNG IL10 IL17A IL5
34 polycystic echinococcosis 12.5
35 cardiac hydatid cysts with intracavitary expansion 11.5
36 partial hydatidiform mole 11.1
37 hydatidiform mole, recurrent, 1 11.0
38 pars planitis 10.3 HLA-B HLA-DRB1
39 idiopathic inflammatory myopathy 10.3 HLA-B HLA-DRB1
40 postherpetic neuralgia 10.3 HLA-B HLA-DRB1
41 periodontitis, chronic 10.3 IL6 TLR2
42 prosthetic joint infection 10.3 TLR2 TLR4
43 fungal keratitis 10.3 TLR2 TLR4
44 juvenile myasthenia gravis 10.3 HLA-DRB1 IL10
45 berylliosis 10.3 HLA-DRB1 IFNG
46 sideroblastic anemia acquired 10.3 MT-ATP6 MT-CO1
47 breast cyst 10.3
48 pouchitis 10.3 IL10 TLR4
49 variola major 10.3 IFNG TLR4
50 eye lymphoma 10.3 IL10 IL6

Graphical network of the top 20 diseases related to Echinococcosis:



Diseases related to Echinococcosis
Sources

Symptoms & Phenotypes for Echinococcosis

About this section

MGI Mouse Phenotypes related to Echinococcosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 CES1 IFNG IL10 IL17A IL5 IL6
2 hematopoietic system MP:0005397 10.06 CCL17 IFNG IL10 IL17A IL5 IL6
3 digestive/alimentary MP:0005381 10.03 IFNG IL10 IL17A IL5 IL6 TLR2
4 immune system MP:0005387 10.02 CCL17 IFNG IL10 IL17A IL5 IL6
5 liver/biliary system MP:0005370 9.86 CES1 IFNG IL10 IL5 IL6 TLR2
6 muscle MP:0005369 9.7 IFNG IL10 IL6 MT-CO1 TLR2 TLR4
7 neoplasm MP:0002006 9.5 IFNG IL10 IL5 IL6 TLR2 TLR4
8 respiratory system MP:0005388 9.23 IFNG IL10 IL17A IL5 IL6 TLR2
Sources

Drugs & Therapeutics for Echinococcosis

About this section

Drugs for Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved 443-48-1 4173
2
Racepinephrine Approved Not Applicable 329-65-7 838
3
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
4
Iodine Approved, Investigational 7553-56-2 807
5
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
6
Mebendazole Approved, Vet_approved Not Applicable 31431-39-7 4030
7 Benzimidazole Experimental, Investigational ,Not Applicable 51-17-2
8 Liver Extracts Not Applicable
9 Antiparasitic Agents ,Not Applicable
10 Anti-Infective Agents ,Not Applicable
11 Anthelmintics ,Not Applicable
12 Epinephryl borate Not Applicable
13 Coagulants Not Applicable
14 Hemostatics Not Applicable
15 cadexomer iodine
16 Antiprotozoal Agents Not Applicable
17 Antimitotic Agents Not Applicable

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Periprosthetic Fracture Following Tibial Echinococcosis Completed NCT03622346 Not Applicable
2 Laparoscopic Versus Open Surgery for the Management of Cystic Echinococcosis of the Liver Completed NCT01643018 Not Applicable
3 Long-term Results of Comprehensive AE Management Completed NCT02509884
4 Epi Cystic Hydatid Disease Peru Completed NCT00138346
5 Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles Completed NCT00658294
6 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212 Not Applicable
7 MR Assessment of Hepatic Hydatid Disease Recruiting NCT03289884
8 Efficacy and Tolerability of Hemopatch After Hepatic Resection Recruiting NCT03323359 Not Applicable
9 Intestinal Parasites in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435
10 Alveolar Echinococcosis: Parasite Viability and Innovative Markers for the Follow-up of Patients Treated With Albendazole Active, not recruiting NCT02876146 Not Applicable Benzimidazole
11 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Echinococcosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: echinococcosis

Sources

Genetic Tests for Echinococcosis

About this section
Sources

Anatomical Context for Echinococcosis

About this section

MalaCards organs/tissues related to Echinococcosis:

41
Liver, Lung, Brain, Testes, Heart, Spleen, Kidney
Sources

Publications for Echinococcosis

About this section

Articles related to Echinococcosis:

(show top 50) (show all 2282)
# Title Authors Year
1
Progress towards international adoption of the World Health Organization ultrasound classification of cystic echinococcosis. ( 30267658 )
2019
2
First description of Echinococcus ortleppi and cystic echinococcosis infection status in Chile. ( 29771992 )
2018
3
Major hepatectomies in liver cystic echinococcosis: A bi-centric experience. Retrospective cohort study. ( 29733994 )
2018
4
Prevalence of abdominal cystic echinococcosis in rural Bulgaria, Romania, and Turkey: a cross-sectional, ultrasound-based, population study from the HERACLES project. ( 29793823 )
2018
5
Seronegative alveolar echinococcosis in a patient with multiple myeloma. ( 29425710 )
2018
6
Cerebral cystic echinococcosis in Mongolian children caused by Echinococcus canadensis. ( 29753095 )
2018
7
Cystic echinococcosis in Turkana, Kenya: 30 years of imaging in an endemic region. ( 29155205 )
2018
8
Impact of affected lymph nodes on long-term outcome after surgical therapy of alveolar echinococcosis. ( 29909530 )
2018
9
Alveolar echinococcosis in the head of pancreas: A case report. ( 29538198 )
2018
10
MR imaging features of peritoneal alveolar echinococcosis. ( 29580747 )
2018
11
The Investigation of the Effect and Mechanism of <i>Sophora moorcroftiana</i> Alkaloids in Combination with Albendazole on Echinococcosis in an Experimental Rats Model. ( 29785189 )
2018
12
Human cystic echinococcosis in Hungary (2000-2014): a retrospective case series analysis from a single-center study. ( 29752648 )
2018
13
Plasma IL-23 and IL-5 as surrogate markers of lesion metabolic activity in patients with hepatic alveolar echinococcosis. ( 29535327 )
2018
14
Knowledge, attitudes and practices related to cystic echinococcosis endemicity in Pakistan. ( 29353554 )
2018
15
Management of cystic echinococcosis in the last two decades: what have we learned? ( 29897552 )
2018
16
Alveolar echinococcosis in a dog; analysis of clinical and histological findings and molecular identification of Echinococcus multilocularis. ( 29975636 )
2018
17
Cystic echinococcosis in animals and humans of Maharashtra State, India. ( 29654685 )
2018
18
Investigation of the Applicability of a Rapid Diagnosis Test in the Diagnosis of Cystic Echinococcosis. ( 29780006 )
2018
19
Single-center experience in the surgical treatment of combined lung Echinococcosis. ( 29332106 )
2018
20
Cystic echinococcosis in a domestic cat (Felis catus) in Italy. ( 29727269 )
2018
21
eComment. New horizons in diagnosing and managing cardiac echinococcosis. ( 29361169 )
2018
22
Seroprevalence of Human Cystic Echinococcosis in Alborz Province, Central Iran in 2015. ( 29900141 )
2018
23
In vitro and in vivo efficacies of carbazole aminoalcohols in the treatment of alveolar echinococcosis. ( 29746870 )
2018
24
Genotype characterization of livestock and human cystic echinococcosis in Mazandaran province, Iran. ( 29446344 )
2018
25
Design and construction of a new recombinant fusion protein (2b2t+EPC1) and its assessment for serodiagnosis of cystic echinococcosis. ( 29696723 )
2018
26
Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets. ( 29677189 )
2018
27
Alveolar echinococcosis in the liver of an adolescent boy. ( 29643103 )
2018
28
Cystic echinococcosis in marketed offal of sheep in Basrah, Iraq: Abattoir-based survey and a probabilistic model estimation of the direct economic losses due to hydatid cyst. ( 29774298 )
2018
29
Transjugular intrahepatic portosystemic shunt for alveolar echinococcosis of the liver and Budd-Chiari syndrome. ( 29891417 )
2018
30
Albendazole nanocrystals in experimental alveolar echinococcosis: Enhanced chemoprophylactic and clinical efficacy in infected mice. ( 29426481 )
2018
31
Performance of the commercially available SERION ELISA classic Echinococcus IgG test for the detection of cystic echinococcosis in clinical practice. ( 29950187 )
2018
32
Knowledge, Awareness and Practices Regarding Cystic Echinococcosis among Livestock Farmers in Basrah Province, Iraq. ( 29415425 )
2018
33
The seroprevalence rate and population genetic structure of human cystic echinococcosis in the Middle East: A systematic review and meta-analysis. ( 29367032 )
2018
34
The choose of different surgical therapies of hepatic alveolar echinococcosis: A single-center retrospective case-control study. ( 29465544 )
2018
35
Ageing impairs parasite-specific antibody responses in cystic echinococcosis. ( 29161459 )
2018
36
Removal notice for Liver autotransplantation and retrohepatic vena cava reconstruction for alveolar echinococcosis [JSR 210 (2017) 169-176]. ( 29433881 )
2018
37
Acute cholangitis complicating a chronic alveolar echinococcosis: an unusual therapeutic cholangioscopy. ( 29895060 )
2018
38
Cystic echinococcosis in Jordan: A review of causative species, previous studies, serological and radiological diagnosis. ( 29246408 )
2018
39
Field evaluation of an immunochromatographic test for diagnosis of cystic and alveolar echinococcosis. ( 29792228 )
2018
40
A Community-Based Study to Estimate the Seroprevalence of Trichinellosis and Echinococcosis in the Roma and Non-Roma Population of Slovakia. ( 29393919 )
2018
41
Computed Tomography Perfusion Imaging for the Diagnosis of Hepatic Alveolar Echinococcosis. ( 29531482 )
2018
42
Preliminary Evidence for the Absence of Cystic Echinococcosis in Gabon: A Cross-Sectional Pilot Survey in Humans and Definitive Hosts. ( 29785924 )
2018
43
Evaluation of kinase-inhibitors nilotinib and everolimus against alveolar echinococcosis inA vitro and in a mouse model. ( 29625098 )
2018
44
Liver transplantation for hepatic alveolar echinococcosis: literature review and three new cases. ( 29363377 )
2018
45
Hepatic alveolar echinococcosis. ( 29653501 )
2018
46
Cardio-abdominal echinococcosis: A man with a visible pulsating abdominal mass. ( 29318110 )
2018
47
Diffusion-Weighted MRI for the Initial Viability Evaluation of Parasites in Hepatic Alveolar Echinococcosis: Comparison with Positron Emission Tomography. ( 29353998 )
2018
48
A novel in silico minigene vaccine based on CD4<sup>+</sup>T-helper and B-cell epitopes of EG95 isolates for vaccination against cystic echinococcosis. ( 29195784 )
2018
49
Preliminary assessment of the diagnostic performances of a new rapid diagnostic test for the serodiagnosis of human cystic echinococcosis. ( 29776711 )
2018
50
In vitro study on protoscolicidal effect of methanolic extract of Allium hirtifolium on protoscoleces of cystic echinococcosis ( 29741144 )
2018
Sources

Variations for Echinococcosis

About this section
Sources

Expression for Echinococcosis

About this section
Search GEO for disease gene expression data for Echinococcosis.
Sources

Pathways for Echinococcosis

About this section

Pathways related to Echinococcosis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14 HLA-B HLA-DRB1 IFNG IL10 IL17A IL5
2
PEDF Induced Signaling 64
Show member pathways
 13.65 CCL17 IFNG IL10 IL17A IL5 IL6
3
TGF-Beta Pathway 64
Show member pathways
 13.51 CCL17 IFNG IL10 IL17A IL5 IL6
4
Akt Signaling 64
Show member pathways
 13.41 CCL17 IL10 IL17A IL5 IL6 TLR2
5
Cytokine Signaling in Immune system 66
Show member pathways
 13.36 HLA-B HLA-DRB1 IFNG IL10 IL17A IL5
6
PAK Pathway 64
Show member pathways
 13.27 CCL17 IL10 IL17A IL5 IL6 TNF
7
Human cytomegalovirus infection 37
Show member pathways
 13.02 HLA-B IL6 TLR2 TLR4 TNF
8
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 13.01 IFNG IL10 IL6 TLR2 TLR4 TNF
9
PI3K-Akt signaling pathway 37
Show member pathways
 12.97 HLA-B IL6 TLR2 TLR4 TNF
10
Allograft rejection 1 37
Show member pathways
 12.85 HLA-B HLA-DRB1 IFNG IL10 IL17A IL5
11
Influenza A 37
Show member pathways
 12.82 HLA-B HLA-DRB1 IFNG IL6 TLR2 TLR4
12
Immune response IL-23 signaling pathway 22
Show member pathways
 12.61 IFNG IL10 IL17A IL6 TNF
13
NF-kappaB Signaling 4
12.59 IFNG IL10 IL17A TLR2 TNF
14
T cell receptor signaling pathway 37
Show member pathways
 12.44 IFNG IL10 IL17A IL5 IL6 TNF
15
Human T-cell leukemia virus 1 infection 37
12.42 HLA-B HLA-DRB1 IL6 TNF
16
JAK-STAT signaling pathway (KEGG) 37
Show member pathways
 12.39 IFNG IL10 IL5 IL6
17
IL-17 Family Signaling Pathways 65
Show member pathways
 12.35 CCL17 IFNG IL17A IL5 IL6 TLR2
18
Th17 cell differentiation 37
Show member pathways
 12.35 HLA-DRB1 IFNG IL10 IL17A IL5 IL6
19
Epstein-Barr virus infection 37
12.34 HLA-B HLA-DRB1 IL6 TLR2 TNF
20
Toll Comparative Pathway 64
Show member pathways
 12.31 IFNG IL6 TLR4 TNF
21
Toxoplasmosis 37
Show member pathways
 12.29 HLA-DRB1 IFNG IL10 TLR2 TLR4 TNF
22
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.28 IL6 TLR2 TLR4 TNF
23
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.25 HLA-B IFNG IL10 IL17A IL5 IL6
24
Bacterial infections in CF airways 22
Show member pathways
 12.24 IFNG IL6 TLR2 TLR4 TNF
25
Colorectal Cancer Metastasis 64
12.24 IFNG IL6 TLR2 TLR4 TNF
26
C-type lectin receptor signaling pathway 37
Show member pathways
 12.23 CCL17 IL10 IL6 TNF
27
Tuberculosis 37
12.2 HLA-DRB1 IFNG IL10 IL6 TLR2 TLR4
28
Phagosome 37
12.16 HLA-B HLA-DRB1 TLR2 TLR4
29
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.12 CCL17 IFNG IL10 IL17A IL5 IL6
30
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 12.1 IFNG IL6 TLR2 TLR4 TNF
31
Spinal Cord Injury 1
12.05 IFNG IL6 TLR4 TNF
32
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
12.05 IFNG IL10 IL5 IL6 TNF
33
Interleukin-4 and 13 signaling 66
12.03 IL10 IL17A IL6 TNF
34
MAPK Pathway 72
Show member pathways
 12 IL5 TLR2 TLR4
35
Th1 Differentiation Pathway 65
Show member pathways
 11.98 IFNG IL10 IL17A IL6 TLR2 TLR4
36
Hematopoietic cell lineage 37
11.94 HLA-DRB1 IL5 IL6 TNF
37
Amoebiasis 37
11.92 IFNG IL10 IL6 TLR2 TLR4 TNF
38
HIF-1 signaling pathway 37
11.9 IFNG IL6 TLR4
39
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.87 IL17A IL6 TLR4
40
Jak-Stat Signaling Pathway (sino) 67
11.85 IFNG IL10 IL6
41
Innate Lymphoid Cell Differentiation Pathways 65
11.85 IFNG IL10 IL17A IL5 TNF
42
Salmonella infection (KEGG) 37
11.83 IFNG IL6 TLR4
43
Pertussis 37
11.83 IL10 IL6 TLR4 TNF
44
Glucocorticoid receptor regulatory network 1
11.81 IFNG IL5 IL6
45
Dendritic Cells Developmental Lineage Pathway 65
11.81 IFNG IL10 IL6 TNF
46
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.77 IFNG IL5 TNF
47
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.7 CCL17 IFNG IL10 IL17A IL6 TNF
48
IL4-mediated signaling events 1
11.68 CCL17 IL10 IL5
49
Lung fibrosis 1
11.68 IL5 IL6 TNF
50
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.68 IFNG IL6 TNF
Sources

GO Terms for Echinococcosis

About this section

Cellular components related to Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.46 HLA-DRB1 IL17A TLR4 TNF
2 cell surface GO:0009986 9.35 HLA-B HLA-DRB1 TLR2 TLR4 TNF
3 extracellular space GO:0005615 9.23 CCL17 CES1 IFNG IL10 IL17A IL5

Biological processes related to Echinococcosis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.89 IL10 IL6 TLR4 TNF
2 cellular response to interferon-gamma GO:0071346 9.86 CCL17 TLR2 TLR4
3 defense response to Gram-positive bacterium GO:0050830 9.86 IL6 TLR2 TNF
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.86 IL6 TLR2 TLR4 TNF
5 cytokine-mediated signaling pathway GO:0019221 9.85 IL10 IL17A IL5 IL6 TNF
6 positive regulation of inflammatory response GO:0050729 9.83 TLR2 TLR4 TNF
7 interferon-gamma-mediated signaling pathway GO:0060333 9.82 HLA-B HLA-DRB1 IFNG
8 response to glucocorticoid GO:0051384 9.81 IL10 IL6 TNF
9 regulation of signaling receptor activity GO:0010469 9.8 CCL17 IFNG IL10 IL17A IL5 IL6
10 humoral immune response GO:0006959 9.79 IFNG IL6 TNF
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.78 TLR2 TLR4 TNF
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 IFNG TLR4 TNF
13 positive regulation of DNA-binding transcription factor activity GO:0051091 9.73 IL10 IL5 IL6 TNF
14 lipopolysaccharide-mediated signaling pathway GO:0031663 9.72 TLR2 TLR4 TNF
15 microglial cell activation GO:0001774 9.71 TLR2 TNF
16 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.71 IL17A TLR4
17 positive regulation of glial cell proliferation GO:0060252 9.71 IL6 TNF
18 positive regulation of macrophage activation GO:0043032 9.71 IL10 TLR4
19 negative regulation of interferon-gamma production GO:0032689 9.71 HLA-DRB1 IL10 TLR4
20 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.7 IFNG TNF
21 negative regulation of growth of symbiont in host GO:0044130 9.7 IL10 TNF
22 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 IL10 TNF
23 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.7 TLR2 TLR4
24 negative regulation of interleukin-6 production GO:0032715 9.7 IL10 TLR4 TNF
25 regulation of cytokine secretion GO:0050707 9.69 TLR2 TLR4
26 I-kappaB phosphorylation GO:0007252 9.68 TLR2 TLR4
27 negative regulation of interleukin-17 production GO:0032700 9.68 IFNG TLR4
28 positive regulation of immunoglobulin secretion GO:0051024 9.68 IL5 IL6
29 positive regulation of podosome assembly GO:0071803 9.67 IL5 TNF
30 response to molecule of bacterial origin GO:0002237 9.67 IL10 TLR2
31 cellular response to lipoteichoic acid GO:0071223 9.67 TLR2 TLR4
32 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.66 TLR4 TNF
33 T-helper 1 type immune response GO:0042088 9.66 HLA-DRB1 TLR4
34 negative regulation of lipid storage GO:0010888 9.65 IL6 TNF
35 endothelial cell apoptotic process GO:0072577 9.65 IL10 TNF
36 positive regulation of interleukin-8 production GO:0032757 9.65 TLR2 TLR4 TNF
37 positive regulation of MHC class II biosynthetic process GO:0045348 9.63 IL10 TLR4
38 negative regulation of cytokine secretion involved in immune response GO:0002740 9.63 IL10 TNF
39 positive regulation of neuroinflammatory response GO:0150078 9.62 IL6 TNF
40 positive regulation of interleukin-6 production GO:0032755 9.62 IL6 TLR2 TLR4 TNF
41 positive regulation of interleukin-23 production GO:0032747 9.61 IFNG IL17A
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 IFNG TNF
43 positive regulation of interleukin-12 production GO:0032735 9.58 IFNG TLR2 TLR4
44 receptor biosynthetic process GO:0032800 9.57 IL10 TNF
45 inflammatory response GO:0006954 9.56 CCL17 IL10 IL17A IL5 IL6 TLR2
46 positive regulation of osteoclast differentiation GO:0045672 9.54 IFNG IL17A TNF
47 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.51 TLR2 TLR4
48 positive regulation of vitamin D biosynthetic process GO:0060557 9.49 IFNG TNF
49 positive regulation of chemokine production GO:0032722 9.46 IL6 TLR2 TLR4 TNF
50 immune response GO:0006955 9.36 CCL17 HLA-B HLA-DRB1 IFNG IL10 IL17A

Molecular functions related to Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CCL17 IFNG IL10 IL17A IL5 IL6
2 lipopolysaccharide receptor activity GO:0001875 8.96 TLR2 TLR4
Sources

Sources for Echinococcosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....