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MCID: ECH003
MIFTS: 52

Echinococcosis

Categories: Infectious diseases, Liver diseases, Neuronal diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Echinococcosis

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MalaCards integrated aliases for Echinococcosis:

Name: Echinococcosis 12 3 44 15 17 70 32
Hydatidosis 12 73 20 15
Echinococcosis, Pulmonary 70
Pulmonary Echinococcosis 12
Echinococcosis of Liver 12
Echinococcosis, Hepatic 70
Hepatic Echinococcosis 12
Echinococcal Disease 12
Liver Echinococcus 12
Hydatid Disease 12
Hydatids 54

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Neuronal diseases Respiratory diseases Liver diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1496
ICD9CM 34 122
MeSH 44 D004443
NCIt 50 C84682
SNOMED-CT 67 154414008
ICD10 32 B67 B67.8
UMLS 70 C0013502 C0013504 C0013505
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Summaries for Echinococcosis

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CDC : 3 Echinococcosis is a parasitic disease caused by infection with tiny tapeworms of the genus Echinocococcus. Echinococcosis is classified as either cystic echinococcosis or alveolar echinococcosis. Cystic echinocccosis (CE), also known as hydatid disease, is caused by infection with the larval stage of Echinococcus granulosus, a ~2-7 millimeter long tapeworm found in dogs (definitive host) and sheep, cattle, goats, and pigs (intermediate hosts). Although most infections in humans are asymptomatic, CE causes harmful, slowly enlarging cysts in the liver, lungs, and other organs that often grow unnoticed and neglected for years. Alveolar echinococcosis (AE) disease is caused by infection with the larval stage of Echinococcus multilocularis, a ~1-4 millimeter long tapeworm found in foxes, coyotes, and dogs (definitive hosts). Small rodents are intermediate hosts for E. multilocularis. Although cases of AE in animals in endemic areas are relatively common, human cases are rare. AE poses a much greater health threat to people than CE, causing parasitic tumors that can form in the liver, lungs, brain, and other organs. If left untreated, AE can be fatal.

MalaCards based summary : Echinococcosis, also known as hydatidosis, is related to polycystic echinococcosis and alveolar echinococcosis. An important gene associated with Echinococcosis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Metronidazole and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and bone, and related phenotypes are immune system and digestive/alimentary

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys.

Wikipedia : 73 Echinococcosis is a parasitic disease of tapeworms of the Echinococcus type. The two main types of the... more...

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Related Diseases for Echinococcosis

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Diseases related to Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 887)
# Related Disease Score Top Affiliating Genes
1 polycystic echinococcosis 32.2 MT-ND1 MT-CO1 CES2
2 alveolar echinococcosis 31.4 TNF TLR4 TLR2 TAP2 MT-CO1 KLRK1
3 obstructive jaundice 30.9 TNF TLR4 IL6
4 trichinosis 30.6 IL5 IL17A IL10
5 toxocariasis 30.6 RNASE3 IL5 IL10
6 cholangitis 30.6 TNF TLR4 IL6 IL10 HLA-DRB1 HLA-B
7 fascioliasis 30.4 MT-ND1 MT-CO1 IL10 IFNG
8 hypereosinophilic syndrome 30.4 RNASE3 IL5 IL10 IFNG CCL17
9 cysticercosis 30.3 TLR4 MT-ND1 MT-CO1 IL6 IL5 IL10
10 salpingitis 30.3 TNF TLR2 IL6
11 pericarditis 30.3 TNF IL6 IFNG
12 amebiasis 30.2 TNF TLR2 IL17A IL10
13 pleurisy 30.2 TNF TLR4 TLR2 IFNG
14 strongyloidiasis 30.2 MT-CO1 IL5 IFNG
15 autoimmune hepatitis 30.2 TNF IL17A IL10 HLA-DRB1
16 sparganosis 30.2 MT-ND1 MT-CO1
17 pulmonary tuberculosis 30.2 TNF TLR2 IL6 IL10 IFNG HLA-DRB1
18 coenurosis 30.1 MT-ND1 MT-CO1
19 cystic echinococcosis 30.1 TLR4 TLR2 TAP2 RNASE3 MT-ND1 MT-CO1
20 stomatitis 30.1 TNF IL6 IL10 IFNG
21 optic neuritis 30.1 TNF IL6 IL10 HLA-DRB1
22 lung abscess 30.1 TNF IL6 IFNG
23 acute pancreatitis 30.1 TNF TLR4 IL6 IL10
24 giardiasis 30.1 IL17A IL10 CD8A
25 disease by infectious agent 30.0 TNF TLR4 TLR2 IL6 IL17A IL10
26 paragonimiasis 30.0 RNASE3 MT-CO1 IL5 CCL17
27 autoimmune lymphoproliferative syndrome 30.0 TNF MT-CO1 IL10 CD8A
28 peritonitis 30.0 TNF TLR4 TLR2 IL6 IL10
29 toxoplasmosis 30.0 TNF TLR4 TLR2 IL6 IL5 IL10
30 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.0 IL17A IL10 IFNG
31 invasive aspergillosis 29.9 TLR4 TLR2 IL10 IFNG
32 ascaris lumbricoides infection 29.9 IL6 IL5 IFNG
33 osteomyelitis 29.9 TNF TLR4 TLR2 IL6 IL10 IFNG
34 actinomycosis 29.9 TNF IL6 IL10
35 guillain-barre syndrome 29.9 TNF IL17A HLA-DRB1
36 neuritis 29.9 TNF IL6 IL10 IFNG HLA-DRB1
37 fasciitis 29.9 TNF IL6 IFNG
38 disseminated intravascular coagulation 29.9 TNF IL6 IL10
39 sclerosing cholangitis 29.9 TNF TLR4 IL6 IL10 HLA-DRB1 HLA-B
40 aspiration pneumonia 29.9 TNF IL6 IL17A
41 radiculopathy 29.9 IL6 IL5 IL17A IL10
42 intestinal obstruction 29.9 TNF IL6 CD8A
43 schistosomiasis 29.9 TNF RNASE3 IL5 IL17A IL10 IFNG
44 ileus 29.8 TNF IL6 IL10
45 pleural disease 29.8 TNF IL6 CD8A
46 atrophic gastritis 29.8 TNF IL6 IL10 HLA-DRB1
47 listeriosis 29.8 TNF TLR2 IL6 IL10 CD8A
48 leptospirosis 29.8 TNF TLR2 IL6 IL10 IFNG
49 sarcoidosis 1 29.8 TNF IFNG HLA-DRB1 CD8A
50 duodenal ulcer 29.8 TNF TLR4 IL6 IL10 HLA-DRB1

Graphical network of the top 20 diseases related to Echinococcosis:



Diseases related to Echinococcosis
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Symptoms & Phenotypes for Echinococcosis

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MGI Mouse Phenotypes related to Echinococcosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.93 CCL17 CD8A IFNG IL10 IL17A IL5
2 digestive/alimentary MP:0005381 9.86 IFNG IL10 IL17A IL5 IL6 TLR2
3 neoplasm MP:0002006 9.5 IFNG IL10 IL5 IL6 TLR2 TLR4
4 respiratory system MP:0005388 9.23 IFNG IL10 IL17A IL5 IL6 TLR2
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Drugs & Therapeutics for Echinococcosis

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Drugs for Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved 443-48-1 4173
2
Epinephrine Approved, Vet_approved 51-43-4 5816
3
Racepinephrine Approved 329-65-7 838
4
Mebendazole Approved, Vet_approved 31431-39-7 4030
5
Albendazole Approved, Vet_approved 54965-21-8 2082
6 Benzimidazole Experimental, Investigational 51-17-2
7 Epinephryl borate
8 Hemostatics
9 Liver Extracts
10 Antiparasitic Agents
11 Tubulin Modulators
12 Antimitotic Agents
13 Antiprotozoal Agents
14 Anthelmintics
15 Anti-Infective Agents

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Multi-metric Quantitative MRI for the Assessment of Hepatic Hydatid Disease- a Pilot Study Unknown status NCT03289884
2 Exploratory Phase IV Randomized Single Blind Study Evaluating the Efficacy and Tolerability of Hemopatch in Improving Time of Hemostasis and Preventing Post-operative Complications After Hepatic Resection Unknown status NCT03323359
3 Bile Leakage Test in Emergency Hydatid Liver Cyst Surgery Case Report Completed NCT04705961
4 VATS Versus Thoracotomy for Pulmonary Hydatid Disease Completed NCT04412512
5 Epidemiology of Human Cystic Hydatid Disease Completed NCT00138346
6 Laparoscopic Versus Open Conservative Surgery for the Management of Cystic Echinococcosis of the Liver: Prospective, Randomized, and Controlled Clinical Trial of Efficacy and Safety Completed NCT01643018
7 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212
8 Management of Liver Hydatid Cysts: A Retrospective Analysis of 293 Cases From Southern Iran Completed NCT04363151
9 Intracranial Hydatid Cyst: Series of 8 Cases Completed NCT04454268
10 Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles in Patients With Inoperable Alveolar Echinococcosis Using PET-CT and EmII/3-10 Serology Completed NCT00658294
11 Comprehensive Diagnosis and Treatment of Alveolar Echinococcosis : A Single-center, Longterm Observational Study of 312 Patients in Germany Completed NCT02509884
12 Periprosthetic Pathologic Fracture Following Tibial Echinococcosis: A Case Report Completed NCT03622346
13 Liver Echinococcosis; Jaundice as Initial Presentation, Short and Long Term Results of Surgical Treatment Active, not recruiting NCT04271176
14 Alveolar Echinococcosis: Parasite Viability and Innovative Markers for Follow-up of Patients Treated With Albendazole - EchinoVISTA Prospective Clinical Study Active, not recruiting NCT02876146 Benzimidazole

Search NIH Clinical Center for Echinococcosis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Albendazole

Cochrane evidence based reviews: echinococcosis

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Genetic Tests for Echinococcosis

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Anatomical Context for Echinococcosis

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MalaCards organs/tissues related to Echinococcosis:

40
Liver, Kidney, Bone, Spleen, Brain, Thyroid, Lung
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Publications for Echinococcosis

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Articles related to Echinococcosis:

(show top 50) (show all 10135)
# Title Authors PMID Year
1
Molecular cross-talk in host-parasite relationships: the intriguing immunomodulatory role of Echinococcus antigen B in cystic echinococcosis. 54 61
18692060 2008
2
Echinococcus granulosus in Jordan: assessment of various antigenic preparations for use in the serodiagnosis of surgically confirmed cases using enzyme immuno assays and the indirect haemagglutination test. 61 54
14972381 2004
3
Echinococcus granulosus-specific T-cell lines derived from patients at various clinical stages of cystic echinococcosis. 61 54
15198645 2004
4
Long-term serological evaluation of patients with cystic echinococcosis treated with benzimidazole carbamates. 54 61
12197890 2002
5
Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses. 61 54
11119517 2001
6
Native and recombinant antigens in the immunodiagnosis of human cystic echinococcosis. 54 61
11116435 2000
7
Immunoglobulin G subclass responses in human cystic and alveolar echinococcosis. 54 61
7810806 1994
8
Comment on "Combining derivative Raman with autofluorescence to improve the diagnosis performance of echinococcosis". 61
33549856 2021
9
Meta-analysis of the prevalence of Echinococcus in dogs in China from 2010 to 2019. 61
33798191 2021
10
Characterization of microRNAs expressed in the cystic legion of the liver of Mus musculus perorally infected with Echinococcus multilocularis Nemuro strain. 61
33238214 2021
11
Extra-hepatopulmonary cystic echinococcosis in Bulgaria: frequency, management and outcome of the disease. 61
33213598 2021
12
Cystic echinococcosis: an emerging zoonosis in southern regions of Khyber Pakhtunkhwa, Pakistan. 61
33794898 2021
13
A case of human cystic echinococcosis acquired in Ireland. 61
33238216 2021
14
Copper nanoparticles: Biosynthesis, characterization, and protoscolicidal effects alone and combined with albendazole against hydatid cyst protoscoleces. 61
33450495 2021
15
A Challenging Diagnosis of Two Ruptured and Intact Pulmonary Echinococcal Cysts in a 54-Year-Old Woman: A Case Report. 61
33811626 2021
16
Comment on "The Value of Hepatic Vein Stent Placement as a Bridge Therapy on Treating Hepatic Alveolar Echinococcosis Presenting With Budd-Chiari Syndrome". 61
33491984 2021
17
The Value of Hepatic Vein Stent Placement as a Bridge Therapy on Treating Hepatic Alveolar Echinococcosis Presenting With Budd-Chiari Syndrome. 61
33214482 2021
18
Evaluation of fecal immunoassays for canine Echinococcus infection in China. 61
33720943 2021
19
Progressive compressive myelopathy induced by a rare primary isolated thoracic vertebral hydatid cyst: A case report. 61
33726007 2021
20
Identification of candidate biomarkers of liver hydatid disease via microarray profiling, bioinformatics analysis, and machine learning. 61
33787392 2021
21
Scolicidal effects of Cassia fistula and Urtica dioica extracts on protoscoleces of hydatid cysts. 61
33746387 2021
22
Primary pericardial hydatid cyst in an asymptomatic butcher. 61
33308341 2021
23
Laparoscopic radical and conservative surgery for hydatid liver echinococcosis: PSM based comparative analysis of immediate and long-term outcomes. 61
33650004 2021
24
Effects of management of infection source of echinococcosis in Linzhi, Tibet Autonomous Region of China. 61
33676564 2021
25
Label-free detection of echinococcosis and liver cirrhosis based on serum Raman spectroscopy combined with multivariate analysis. 61
33373744 2021
26
Echinococcosis in both heart and lungs, the first case reported in Albania. 61
33752766 2021
27
Effect of intensity-modulated radiation therapy on sciatic nerve injury caused by echinococcosis. 61
32985491 2021
28
An arcane case report of primary intramuscular hydatid cyst of thigh. 61
33592423 2021
29
Phylogenetics and Pathology of Hydatid Disease in Slaughtered Buffaloes of North India. 61
33687645 2021
30
One-stage surgery for both hepatic and left ventricular hydatid cysts using transthoracic route. 61
33768793 2021
31
Echinococcus granulosus sensu lato and Echinococcus multilocularis: A review. 61
33246571 2021
32
Characterizing dynamic changes of plasma cell-free Echinococcus granulosus DNA before and after cystic echinococcosis treatment initiation. 61
33383141 2021
33
Expression profiling of Echinococcus multilocularis miRNAs throughout metacestode development in vitro. 61
33750964 2021
34
In vivo efficacy of combination therapy with albendazole and atovaquone against primary hydatid cysts in mice. 61
33770336 2021
35
Metastases of Alveolar Echinococcosis to the Skin, Pleura, Ribs, and the Xiphoid Process: A Case Report. 61
32376067 2021
36
Local invasion of hepatic alveolar echinococcosis should not be underestimated: Lessons learned from imaging-pathologic correlation. 61
33500218 2021
37
Alveolar Echinococcosis of the Liver with a Rare Infiltration of the Adrenal Gland. 61
33664623 2021
38
microRNA-125b-5p is a promising novel plasma biomarker for alveolar echinococcosis in patients from the southern province of Qinghai. 61
33678159 2021
39
Investigating new serological and tissue markers for the follow-up of patients operated for alveolar echinococcosis. 61
33655559 2021
40
Formal Comment; Tracing the source of infection of cystic and alveolar echinococcosis, neglected parasitic infections with long latency: The shaky road of "evidence" gathering. 61
33784305 2021
41
Innate and adaptive immune responses following PD-L1 blockade in treating chronic murine alveolar echinococcosis. 61
33754355 2021
42
Polyreactive antibodies as potential humoral biomarkers of host resistance to cystic echinococcosis. 61
33098129 2021
43
Renal Cystic Echinococcosis: Long-term Outcomes of Percutaneous Treatment. 61
33727151 2021
44
Expression profile of circular RNAs in cystic echinococcosis pericystic tissue. 61
33411343 2021
45
Omentoplasty decreases deep organ space surgical site infection compared with external tube drainage after conservative surgery for hepatic cystic echinococcosis: Meta-analysis with a meta-regression. 61
33771491 2021
46
Cystic echinococcosis in sheep and goats of Lebanon. 61
33757607 2021
47
Control of cystic echinococcosis in the Middle Atlas, Morocco: Field evaluation of the EG95 vaccine in sheep and cesticide treatment in dogs. 61
33684115 2021
48
Automatic Classification of Hepatic Cystic Echinococcosis Using Ultrasound Images and Deep Learning. 61
33710638 2021
49
Dynamic modeling and optimal control of cystic echinococcosis. 61
33762009 2021
50
Comparative Evaluation of the Efficacy of Indirect Hemagglutination Test and Radiological Methods in the Pre-diagnosis of Cystic Echinococcosis 61
33685064 2021
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Variations for Echinococcosis

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Expression for Echinococcosis

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Search GEO for disease gene expression data for Echinococcosis.
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Pathways for Echinococcosis

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Pathways related to Echinococcosis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.06 TNF TLR4 TLR2 TAP2 RNASE3 KLRK1
2
Akt Signaling 63
Show member pathways
 13.43 TNF TLR4 TLR2 IL6 IL5 IL17A
3
Cytokine Signaling in Immune system 65
Show member pathways
 13.39 TNF IL6 IL5 IL17A IL10 IFNG
4
Human cytomegalovirus infection 36
Show member pathways
 12.97 TNF TLR4 TLR2 TAP2 IL6 HLA-B
5
Herpes simplex virus 1 infection 36
12.87 TNF TLR2 TAP2 IL6 IFNG HLA-DRB1
6
Measles 36
Show member pathways
 12.86 TNF TLR4 TLR2 TAP2 IL6 IFNG
7
Prion disease 36
Show member pathways
 12.84 TNF MT-ND1 MT-CO1 MT-ATP6 IL6
8
NF-kappaB Signaling 4
12.63 TNF TLR2 TAP2 IL17A IL10 IFNG
9
T cell receptor signaling pathway 36
Show member pathways
 12.63 TNF TLR4 TLR2 IL6 IL5 IL17A
10
Immune response IL-23 signaling pathway 23
Show member pathways
 12.62 TNF IL6 IL17A IL10 IFNG
11
Th17 cell differentiation 36
Show member pathways
 12.6 TNF TLR4 TLR2 IL6 IL5 IL17A
12
Antigen processing-Cross presentation 65
Show member pathways
 12.51 TLR4 TLR2 TAP2 HLA-B CD8A
13
Allograft rejection 36 1
Show member pathways
 12.44 TNF TAP2 RNASE3 IL6 IL5 IL17A
14
JAK-STAT signaling pathway 36
Show member pathways
 12.42 IL6 IL5 IL10 IFNG
15
IL-17 Family Signaling Pathways 64
Show member pathways
 12.41 TNF TLR2 IL6 IL5 IL17A IFNG
16
Human T-cell leukemia virus 1 infection 36
12.36 TNF IL6 HLA-DRB1 HLA-B
17
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.35 TNF IL6 IL10 CCL17
18
Toxoplasmosis 36
Show member pathways
 12.34 TNF TLR4 TLR2 IL10 IFNG HLA-DRB1
19
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.33 TNF IL6 IL5 IL17A IL10 IFNG
20
Tuberculosis 36
12.31 TNF TLR4 TLR2 IL6 IL10 IFNG
21
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.28 TNF TLR4 TLR2 IL6
22
Colorectal Cancer Metastasis 63
12.27 TNF TLR4 TLR2 IL6 IFNG
23
Bacterial infections in CF airways 23
Show member pathways
 12.27 TNF TLR4 TLR2 IL6 IFNG
24
C-type lectin receptor signaling pathway 36
Show member pathways
 12.24 TNF IL6 IL10 CCL17
25
Phagosome 36
12.22 TLR4 TLR2 TAP2 HLA-DRB1 HLA-B
26
Yersinia infection 36
12.17 TNF TLR4 IL6 IL10 CD8A
27
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
12.07 TNF KLRK1 IL6 IL5 IL10 IFNG
28
Spinal Cord Injury 1
12.05 TNF TLR4 IL6 IFNG
29
Interleukin-4 and 13 signaling 65
12.02 TNF IL6 IL17A IL10
30
Amoebiasis 36
12.01 TNF TLR4 TLR2 IL6 IL10 IFNG
31
Hematopoietic cell lineage 36
11.99 TNF IL6 IL5 HLA-DRB1 CD8A
32
Th17 Differentiation Pathway 64
Show member pathways
 11.95 TLR4 TLR2 IL6 IL17A IFNG
33
Rheumatoid arthritis 36
11.88 TNF TLR4 TLR2 IL6 IL17A IFNG
34
Pertussis 36
11.84 TNF TLR4 IL6 IL10
35
Dendritic Cells Developmental Lineage Pathway 64
11.82 TNF IL6 IL10 IFNG CD8A
36
Glucocorticoid receptor regulatory network 1
11.81 IL6 IL5 IFNG
37
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.77 TNF IL5 IFNG
38
IgA-Producing B Cells in the Intestine 64
11.77 TNF TLR4 TLR2 IL6 IL5 IL10
39
Innate Lymphoid Cell Differentiation Pathways 64
11.77 TNF KLRK1 IL5 IL17A IL10 IFNG
40
Legionellosis 36
11.7 TNF TLR4 TLR2 IL6
41
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.69 TNF IL6 IFNG
42
Lung fibrosis 1
11.68 TNF IL6 IL5
43
IL4-mediated signaling events 1
11.68 IL5 IL10 CCL17
44
Th1 Differentiation Pathway 64
Show member pathways
 11.68 TNF TLR4 TLR2 IL6 IL17A IL10
45
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.67 TNF IFNG CD8A
46
MSP-RON Signaling 63
11.61 TNF TLR4 TLR2 IFNG
47
Th2 Differentiation Pathway 64
11.59 IL5 IL10 IFNG CCL17
48
Photodynamic therapy-induced AP-1 survival signaling. 1
11.58 TNF IL6 IFNG
49
Interleukin-10 signaling 65
11.56 TNF IL6 IL10
50
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.52 TNF IL6 IFNG
Sources

GO Terms for Echinococcosis

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Cellular components related to Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.63 TNF TLR4 TLR2 KLRK1 HLA-DRB1 HLA-B
2 phagocytic vesicle membrane GO:0030670 9.43 TLR2 TAP2 HLA-B
3 external side of plasma membrane GO:0009897 9.43 TNF TLR4 KLRK1 IL17A HLA-DRB1 CD8A
4 extracellular space GO:0005615 9.36 TNF RNASE3 MIR26B IL6 IL5 IL17A

Biological processes related to Echinococcosis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 10.13 TLR4 TLR2 RNASE3 KLRK1 IL17A HLA-B
2 positive regulation of gene expression GO:0010628 10.12 TNF TLR4 TLR2 IL6 IFNG
3 immune system process GO:0002376 10.11 TLR4 TLR2 TAP2 KLRK1 IL17A HLA-DRB1
4 cytokine-mediated signaling pathway GO:0019221 10.04 TNF IL6 IL5 IL17A IL10
5 adaptive immune response GO:0002250 10.04 TAP2 KLRK1 IL17A IFNG HLA-DRB1 HLA-B
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 10 TNF TLR4 HLA-DRB1 CCL17
7 cellular response to lipopolysaccharide GO:0071222 9.97 TNF TLR4 IL6 IL10
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.96 TNF TLR4 TLR2 IL6
9 inflammatory response GO:0006954 9.95 TNF TLR4 TLR2 IL6 IL5 IL17A
10 positive regulation of DNA-binding transcription factor activity GO:0051091 9.91 TNF IL6 IL5 IL10
11 regulation of insulin secretion GO:0050796 9.88 TNF IL6 IFNG
12 negative regulation of interleukin-6 production GO:0032715 9.88 TNF TLR4 IL10
13 interferon-gamma-mediated signaling pathway GO:0060333 9.88 IFNG HLA-DRB1 HLA-B
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.88 TNF IL6 IFNG
15 positive regulation of inflammatory response GO:0050729 9.88 TNF TLR4 TLR2 IFNG
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.87 TNF TLR4 TLR2
17 response to glucocorticoid GO:0051384 9.87 TNF IL6 IL10
18 defense response to Gram-negative bacterium GO:0050829 9.87 TLR4 RNASE3 IL6 IL17A
19 humoral immune response GO:0006959 9.86 TNF IL6 IFNG
20 positive regulation of cytokine production GO:0001819 9.85 TNF IL10 IFNG
21 defense response to Gram-positive bacterium GO:0050830 9.85 TNF TLR2 RNASE3 IL6 IL17A
22 positive regulation of interleukin-8 production GO:0032757 9.84 TNF TLR4 TLR2 IL6
23 antigen processing and presentation GO:0019882 9.83 HLA-DRB1 HLA-B CD8A
24 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 TNF TLR4 IFNG
25 negative regulation of interferon-gamma production GO:0032689 9.82 TLR4 IL10 HLA-DRB1
26 positive regulation of interleukin-10 production GO:0032733 9.82 TLR4 TLR2 IL6
27 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 TNF TLR4 TLR2
28 microglial cell activation GO:0001774 9.79 TNF TLR2 IFNG
29 positive regulation of interleukin-12 production GO:0032735 9.78 TLR4 TLR2 IL17A IFNG
30 positive regulation of tumor necrosis factor production GO:0032760 9.77 TLR4 TLR2 IL6 IL17A IFNG
31 positive regulation of osteoclast differentiation GO:0045672 9.75 TNF IL17A IFNG
32 positive regulation of immunoglobulin production GO:0002639 9.73 IL6 IL5 IL10
33 positive regulation of JAK-STAT cascade GO:0046427 9.73 TNF IL6 IL5 IL10
34 negative regulation of amyloid-beta clearance GO:1900222 9.72 TNF IFNG
35 positive regulation of podosome assembly GO:0071803 9.72 TNF IL5
36 negative regulation of chemokine production GO:0032682 9.72 MIR26B IL6
37 response to molecule of bacterial origin GO:0002237 9.72 TLR2 IL10
38 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.72 TLR4 TLR2 IFNG
39 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.71 TNF TLR4
40 cellular response to lipoteichoic acid GO:0071223 9.71 TLR4 TLR2
41 T-helper 1 type immune response GO:0042088 9.71 TLR4 HLA-DRB1
42 negative regulation of lipid storage GO:0010888 9.7 TNF IL6
43 positive regulation of MHC class II biosynthetic process GO:0045348 9.7 TLR4 IL10 IFNG
44 endothelial cell apoptotic process GO:0072577 9.69 TNF IL10
45 vascular endothelial growth factor production GO:0010573 9.68 TNF IL6
46 negative regulation of cytokine production involved in immune response GO:0002719 9.68 TNF IL10
47 intestinal epithelial structure maintenance GO:0060729 9.67 TLR4 IL17A
48 positive regulation of interleukin-23 production GO:0032747 9.67 IL17A IFNG
49 positive regulation of interleukin-1 beta production GO:0032731 9.65 TNF TLR4 IL6 IL17A IFNG
50 positive regulation of matrix metallopeptidase secretion GO:1904466 9.63 TLR4 TLR2

Molecular functions related to Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.33 TAP2 HLA-DRB1 HLA-B
2 lipopolysaccharide receptor activity GO:0001875 9.26 TLR4 TLR2
3 cytokine activity GO:0005125 9.17 TNF IL6 IL5 IL17A IL10 IFNG
4 lipopolysaccharide binding GO:0001530 9.13 TLR4 TLR2 RNASE3
Sources

Sources for Echinococcosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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