MCID: ECH003
MIFTS: 54

Echinococcosis

Categories: Infectious diseases, Liver diseases, Neuronal diseases, Rare diseases, Respiratory diseases
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Aliases & Classifications for Echinococcosis

MalaCards integrated aliases for Echinococcosis:

Name: Echinococcosis 11 2 43 14 16 71 75 31 33
Hydatidosis 11 19 75 14 33
Echinococcus Multilocularis Infection 33
Echinococcus Granulosus Infestation 33
Echinococcus Granulosus Infection 33
Unilocular Echinococcosis 33
Echinococcosis, Pulmonary 71
Pulmonary Echinococcosis 11
Echinococcosis of Liver 11
Echinococcosis, Hepatic 71
Hepatic Echinococcosis 11
Dog Tapeworm Infection 33
Cystic Echinococcosis 33
Echinococcal Disease 11
Echinococcus Disease 33
Liver Echinococcus 11
Hydatid Disease 11
Echinococciasis 33
Hydatids 53

Classifications:



External Ids:

Disease Ontology 11 DOID:1496
ICD9CM 34 122
MeSH 43 D004443
NCIt 49 C84682
SNOMED-CT 68 154414008
ICD10 31 B67 B67.8
UMLS 71 C0013502 C0013504 C0013505

Summaries for Echinococcosis

CDC: 2 Echinococcosis is a parasitic disease caused by infection with tiny tapeworms of the genus Echinocococcus. Echinococcosis is classified as either cystic echinococcosis or alveolar echinococcosis. Cystic echinocccosis (CE), also known as hydatid disease, is caused by infection with the larval stage of Echinococcus granulosus, a ~2-7 millimeter long tapeworm found in dogs (definitive host) and sheep, cattle, goats, and pigs (intermediate hosts). Although most infections in humans are asymptomatic, CE causes harmful, slowly enlarging cysts in the liver, lungs, and other organs that often grow unnoticed and neglected for years. Alveolar echinococcosis (AE) disease is caused by infection with the larval stage of Echinococcus multilocularis, a ~1-4 millimeter long tapeworm found in foxes, coyotes, and dogs (definitive hosts). Small rodents are intermediate hosts for E. multilocularis. Although cases of AE in animals in endemic areas are relatively common, human cases are rare. AE poses a much greater health threat to people than CE, causing parasitic tumors that can form in the liver, lungs, brain, and other organs. If left untreated, AE can be fatal.

MalaCards based summary: Echinococcosis, also known as hydatidosis, is related to alveolar echinococcosis and cystic echinococcosis. An important gene associated with Echinococcosis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Metronidazole and Albendazole have been mentioned in the context of this disorder. Affiliated tissues include liver, spleen and brain, and related phenotypes are neoplasm and immune system

GARD: 19 Hydatidosis or cyst hydatic disease is a cosmopolitan larval cestodosis caused principally by the Echinococcus granulosus tapeworm, the adult form of which parasitises the intestine of dogs. Hydatidosis generally affects large domestic herbivores; humans are dead-end hosts, infected through contact with herding dogs or through ingestion of food contaminated with canine excrement.

Disease Ontology: 11 A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys.

Wikipedia: 75 Echinococcosis is a parasitic disease of tapeworms of the Echinococcus type. The two main types of the... more...

Related Diseases for Echinococcosis

Diseases related to Echinococcosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1061)
# Related Disease Score Top Affiliating Genes
1 alveolar echinococcosis 33.1 MT-CO1 IL5 IL10 CD8A
2 cystic echinococcosis 33.0 MT-CO1 MT-ATP6 IL10
3 cysticercosis 31.1 TLR4 MT-CO1 IL6 IL5 IL10
4 fascioliasis 30.8 MT-CO1 IL10 IFNG
5 hypereosinophilic syndrome 30.6 RNASE3 IL5 IL10 IFNG CCL17
6 toxocariasis 30.5 RNASE3 IL6 IL5 IL10
7 mouth disease 30.5 TLR4 IL6 IL10 IFNG
8 lung abscess 30.3 TNF IL6 IFNG
9 pericarditis 30.3 TNF IL6 IFNG
10 trichinosis 30.2 TNF IL6 IL5 IL17A IL10
11 paragonimiasis 30.1 RNASE3 MT-CO1 IL5 CCL17
12 liver cirrhosis 30.1 TNF TLR2 IL6 HLA-DRB1
13 taeniasis 30.1 TNF TLR4 MT-CO1 IL6 IL5 IL10
14 sparganosis 30.1 MT-CO1 MT-ATP6
15 viral hepatitis 30.1 TLR2 IL6 IFNG HLA-DRB1 HLA-DQB1
16 stomatitis 30.1 TNF IL6 IL10 IFNG
17 bronchiectasis 30.1 TNF TLR2 IL6 IFNG
18 cholangitis 30.1 TNF TLR4 IL6 IL17A IL10 HLA-DRB1
19 neuritis 30.1 TNF IL6 IL10 IFNG
20 spinal cord disease 30.1 TNF IL6 IL10 CD8A
21 ancylostomiasis 30.0 MT-CO1 IL5
22 schistosomiasis 30.0 TNF RNASE3 IL5 IL17A IL10 IFNG
23 acute pancreatitis 30.0 TNF TLR4 IL6 IL10
24 polyarteritis nodosa 30.0 TNF IL6 HLA-DRB1
25 alopecia 30.0 TNF IL6 IL17A IFNG HLA-DRB1
26 paine syndrome 30.0 TNF IL6 IL10
27 enterobiasis 29.9 MT-CO1 IL5
28 salpingitis 29.9 TNF TLR4 TLR2 IL6 IL10
29 chronic recurrent multifocal osteomyelitis 29.9 TNF IL6 IL10
30 encephalitis 29.9 TNF TLR2 IL6 IL10
31 adult respiratory distress syndrome 29.9 TNF MIR146A IL6 IL10
32 calcinosis 29.9 TNF HLA-DRB1 HLA-DQB1
33 giardiasis 29.9 IL17A IL10 CD8A
34 acquired immunodeficiency syndrome 29.9 TNF IL6 IL10 IFNG HLA-B
35 anemia, autoimmune hemolytic 29.9 IL6 IL10 CD8A
36 urinary schistosomiasis 29.9 RNASE3 IL5 IL10
37 hydrocephalus 29.9 TNF TLR4 IL10 IFNG
38 fasciitis 29.9 TNF IL6 IFNG
39 toxoplasmosis 29.8 TNF IL6 IL5 IL17A IL10 IFNG
40 histiocytosis 29.8 TNF IL17A IFNG
41 amebiasis 29.8 TNF TLR4 TLR2 IL6 IL17A IL10
42 pulmonary tuberculosis 29.8 TNF TLR4 TLR2 IL6 IL10 IFNG
43 endomyocardial fibrosis 29.8 TNF RNASE3 IL5 IL10
44 strongyloidiasis 29.8 MT-CO1 IL5 IL10 IFNG
45 syphilis 29.8 TNF TLR2 IL17A HLA-DRB1 CD8A
46 optic neuritis 29.8 TNF IL6 IL10 HLA-DRB1 HLA-DQB1 HLA-B
47 urinary tract infection 29.8 TNF TLR4 TLR2 IL6 IL10
48 intestinal schistosomiasis 29.8 TNF MT-CO1 IL5 IL17A IL10
49 toxic shock syndrome 29.8 TNF TLR4 TLR2 IL6 IL10 IFNG
50 disseminated intravascular coagulation 29.8 TNF IL6 IL10

Graphical network of the top 20 diseases related to Echinococcosis:



Diseases related to Echinococcosis

Symptoms & Phenotypes for Echinococcosis

MGI Mouse Phenotypes related to Echinococcosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 10.06 IFNG IL10 IL5 IL6 KLRK1 MIR146A
2 immune system MP:0005387 10.06 CCL17 CD8A HLA-B HLA-DQB1 IFNG IL10
3 muscle MP:0005369 9.97 HLA-DQB1 IFNG IL10 IL6 MT-CO1 TLR2
4 liver/biliary system MP:0005370 9.97 HLA-DQB1 IFNG IL10 IL17A IL5 IL6
5 digestive/alimentary MP:0005381 9.96 HLA-B HLA-DQB1 IFNG IL10 IL17A IL5
6 respiratory system MP:0005388 9.61 HLA-DQB1 IFNG IL10 IL17A IL5 IL6
7 hematopoietic system MP:0005397 9.5 CCL17 CD8A HLA-B HLA-DQB1 IFNG IL10

Drugs & Therapeutics for Echinococcosis

Drugs for Echinococcosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved 443-48-1, 69198-10-3 4173
2
Albendazole Approved, Vet_approved 54965-21-8 2082
3
Mebendazole Approved, Vet_approved 31431-39-7 4030
4
Benzimidazole Experimental, Investigational 51-17-2 5798
5 Liver Extracts
6 Antiparasitic Agents
7 Anti-Infective Agents
8 Antimitotic Agents
9 Antiprotozoal Agents
10 Anthelmintics
11 Tubulin Modulators
12 Pharmaceutical Solutions
13 Anesthetics

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Liver Echinococcosis; Jaundice as Initial Presentation, Short and Long Term Results of Surgical Treatment Unknown status NCT04271176
2 Multi-metric Quantitative MRI for the Assessment of Hepatic Hydatid Disease- a Pilot Study Unknown status NCT03289884
3 Laparoscopic Versus Open Conservative Surgery for the Management of Cystic Echinococcosis of the Liver: Prospective, Randomized, and Controlled Clinical Trial of Efficacy and Safety Completed NCT01643018
4 VATS Versus Thoracotomy for Pulmonary Hydatid Disease Completed NCT04412512
5 Surgical Treatment of Hepatic Hydatidosis in Elderly Patients Completed NCT05113550
6 The Influence of Two Different Hepatectomy Methods on Transection Speed and Chemokine Release From the Liver Completed NCT01785212
7 Outcome After Surgical Treatment of Liver Hydatid Cyst Completed NCT05420155
8 Analysis of the Potentially Parasitocidal Effect of a Long Term Chemotherapy With Benzimidazoles in Patients With Inoperable Alveolar Echinococcosis Using PET-CT and EmII/3-10 Serology Completed NCT00658294
9 Comprehensive Diagnosis and Treatment of Alveolar Echinococcosis : A Single-center, Longterm Observational Study of 312 Patients in Germany Completed NCT02509884
10 Periprosthetic Pathologic Fracture Following Tibial Echinococcosis: A Case Report Completed NCT03622346
11 Alveolar Echinococcosis: Parasite Viability and Innovative Markers for Follow-up of Patients Treated With Albendazole - EchinoVISTA Prospective Clinical Study Completed NCT02876146 Benzimidazole
12 Management of Liver Hydatid Cysts: A Retrospective Analysis of 293 Cases From Southern Iran Completed NCT04363151
13 Epidemiology of Human Cystic Hydatid Disease Completed NCT00138346
14 Splenic Preserving Surgery in Hydatid Spleen Completed NCT04890899
15 Intracranial Hydatid Cyst: Series of 8 Cases Completed NCT04454268
16 Occult Cysto-biliary Communication and Cyst Fluid Analysis Predicts Post-operative Biliary Fistula and Late Recurrence After Laparoscopic Partial Cystectomy With Omentoplasty in Solitary Primary Adult Liver Hydatid Cyst Disease - A Prospective Multicenter Study. Completed NCT05116735
17 Radical Versus Conservative Surgical Treatment of Liver Hydatid Cysts: A Propensity Score Matching Analysis Completed NCT04988958
18 Systematic Review of Hypernatremia Following Hydatid Cyst Treatment Recruiting NCT05090020

Search NIH Clinical Center for Echinococcosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Albendazole

Cochrane evidence based reviews: echinococcosis

Genetic Tests for Echinococcosis

Anatomical Context for Echinococcosis

Organs/tissues related to Echinococcosis:

MalaCards : Liver, Spleen, Brain, Heart, Lung, Spinal Cord, Adrenal Gland

Publications for Echinococcosis

Articles related to Echinococcosis:

(show top 50) (show all 14128)
# Title Authors PMID Year
1
Molecular cross-talk in host-parasite relationships: the intriguing immunomodulatory role of Echinococcus antigen B in cystic echinococcosis. 53 62
18692060 2008
2
Echinococcus granulosus in Jordan: assessment of various antigenic preparations for use in the serodiagnosis of surgically confirmed cases using enzyme immuno assays and the indirect haemagglutination test. 53 62
14972381 2004
3
Echinococcus granulosus-specific T-cell lines derived from patients at various clinical stages of cystic echinococcosis. 53 62
15198645 2004
4
Long-term serological evaluation of patients with cystic echinococcosis treated with benzimidazole carbamates. 53 62
12197890 2002
5
Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses. 53 62
11119517 2001
6
Native and recombinant antigens in the immunodiagnosis of human cystic echinococcosis. 53 62
11116435 2000
7
Immunological responses to antigen B from Echinococcus granulosus cyst fluid in hydatid patients. 53 62
9226695 1996
8
Immunoglobulin G subclass responses in human cystic and alveolar echinococcosis. 53 62
7810806 1994
9
Identification and diagnostic value of a major antibody epitope on the 12 kDa antigen from Echinococcus granulosus (hydatid disease) cyst fluid. 53 62
7517028 1994
10
Echinococcus granulosus: the potential use of specific radiolabelled antibodies in diagnosis by immunoscintigraphy. 53 62
2357849 1990
11
Mediastinal and pericardial hydatidosis: A case report with review of the literature. 62
36465165 2023
12
The impact of natural environment on human alveolar echinococcosis: A township-level modeling study in Qinghai-Tibet Plateau. 62
36179829 2023
13
7T Small Animal MRI Research for Hepatic Alveolar Echinococcosis. 62
36469640 2022
14
Risk factors for post-endoscopic retrograde cholangiopancreatography cholangitis in patients with hepatic alveolar echinococcosis-an observational study. 62
35792762 2022
15
Application of hepatic lobe hyperplasia techniques in the treatment of advanced hepatic alveolar echinococcosis: a single-centre experience. 62
36474286 2022
16
[Extended Liver Resection with Complex Vascular Reconstruction in Locally Advanced Alveolar Echinococcosis]. 62
35500589 2022
17
Data on the combined effect of atovaquone, mefloquine, and 3-bromopyruvic acid against Echinococcus multilocularis protoscoleces. 62
36426011 2022
18
A CT-based radiomics nomogram for the differentiation of pulmonary cystic echinococcosis from pulmonary abscess. 62
36181541 2022
19
Tropical parasitic itch in returned travellers and immigrants from endemic areas. 62
35793476 2022
20
Enhancing respiratory disease diagnosis by bronchoalveolar lavage in Kashmir: an audit of findings. 62
35948407 2022
21
Primary pancreatic echinococcosis: A rare mimicking of choledochal cyst. 62
35792036 2022
22
Cerebral hydatid cyst in children: A case series of 21 patients and review of literature. 62
35907445 2022
23
Efficacy of Mesenchymal Stem Cells Therapy in Parasitic Infections: Are Anti-parasitic Drugs Combined with MSCs More Effective? 62
36280646 2022
24
First detection of Echinococcus multilocularis in Bosnia and Herzegovina. 62
36406035 2022
25
In vitro efficacy of albendazole-loaded β-cyclodextrin against protoscoleces of Echinococcus granulosus sensu stricto. 62
36384195 2022
26
Alterations in Gut Microbiota Profiles of Mice Infected with Echinococcus granulosus sensu lato Microbiota Profiles of Mice Infected with E. granulosus s.l. 62
36048399 2022
27
Morbidity and Mortality Risk Factors for Lung Hydatidosis Surgery: Over 30 Years' Experience Review. 62
34808112 2022
28
A rare case of hydatid cyst of the neck with concurrent pulmonary hydatid disease. 62
36457772 2022
29
Authors' Response to Letter "Inaccurate sonographic diagnosis of hepatic CE can be dangerous - Remarks on "Echinococcosis: a Challenge for Liver Sonography" by W. Kratzer et al Ultraschall in Med. 24 February 2022." 62
36323328 2022
30
Mathematical modelling of echinococcosis in human, dogs and sheep with intervention. 62
35635312 2022
31
Severe multilobar lung echinococcosis with multiorgan involvement in a child. 62
35962551 2022
32
Anti-echinococcal effects of sumac, Rhus coriaria, in a murine model of cystic echinococcosis: Parasitological and molecular evaluation. 62
36244447 2022
33
A Comparative Evaluation of Four Different Immunoassays in the Diagnosis of Cystic Echinococcosis Using a Crude and Purified Hydatid Cyst Fluid Antigen. 62
36125652 2022
34
Meta-analysis of the prevalence of bovine cystic echinococcosis in China during decade. 62
36150257 2022
35
Deciphering the role of miR-71 and let-7 in the fertility of cystic echinococcosis cysts: a preliminary assessment. 62
36266590 2022
36
'Fight the parasite': raising awareness of cystic echinococcosis in primary school children in endemic countries. 62
36461072 2022
37
Isolated peritoneal involvement as a primary manifestation of cystic echinococcosis. 62
36435190 2022
38
Inaccurate Sonographic Diagnosis of Hepatic CE Can Be Dangerous - Remarks on "Echinococcosis: A Challenge for Liver Sonography" by W. Kratzer et al Ultraschall in Med. 24 February 2022. 62
35944579 2022
39
[Patient with pulmonary cysts and diagnosis of co-infection with tuberculosis and hydatidosis. Pediatric cases report]. 62
36374065 2022
40
Is There Any Role of Pulmonary Endarterectomy in Pulmonary Arterial Hydatidosis? 62
34843694 2022
41
Histopathological and immunological study of rats liver hydatid cysts isolated from human, sheep, goat and cows. 62
36457784 2022
42
Aortic aneurysm lesions in Echinococcus infection. A review of cases in literature. 62
36257589 2022
43
Spontaneous cutaneous fistula secondary to hepatic hydatidosis. 62
36435381 2022
44
The role of the TGF-β/LIF signaling pathway mediated by SMADs during the cyst formation of Echinococcus in young children. 62
36443650 2022
45
Peritoneal hydatidosis: An exceptional case report. 62
36389191 2022
46
Hydatid Disease of the Liver Presenting as Spontaneous Cutaneous Fistula: A case report. 62
36407698 2022
47
Multiple recurrent cystic hydatid disease of abdominal cavity. 62
35643904 2022
48
Hydatid disease of the brain and spine. 62
36443475 2022
49
Primary hydatid cyst of the kidney revealed by hydatiduria: A case report. 62
36212223 2022
50
Hydatid liver disease with portal vein invasion, cavernous transformation and portal biliopathy. 62
35485257 2022

Variations for Echinococcosis

Expression for Echinococcosis

Search GEO for disease gene expression data for Echinococcosis.

Pathways for Echinococcosis

Pathways related to Echinococcosis according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 CD8A HLA-B HLA-DQB1 HLA-DRB1 IFNG IL10
2
Show member pathways
13.64 TNF TLR4 IL6 IL5 IL17A IL10
3
Show member pathways
13.54 TLR4 TLR2 TAP2 KLRK1 HLA-DRB1 HLA-DQB1
4
Show member pathways
13.42 TNF TLR4 TLR2 IL6 IL5 IL17A
5
Show member pathways
13.32 TNF IL6 IL5 IL17A IL10 IFNG
6
Show member pathways
12.85 TNF TLR4 TLR2 MIR146A IL6
7
Show member pathways
12.65 TNF IL6 IL5 IL17A IL10 IFNG
8
Show member pathways
12.62 TNF IL6 IL17A IL10 IFNG
9 12.57 TNF TLR2 TAP2 IL17A IL10 IFNG
10
Show member pathways
12.52 TNF TLR4 TLR2 IL6
11
Show member pathways
12.44 TNF TLR4 TLR2 IL6 IFNG
12
Show member pathways
12.35 HLA-B TAP2 TLR2 TLR4
13
Show member pathways
12.33 TNF TLR4 IL6 IFNG
14
Show member pathways
12.29 TNF TLR2 IL6 IL17A
15 12.23 TNF TLR4 TLR2 IL6 IFNG
16
Show member pathways
12.16 TNF IL5 IL17A IL10 IFNG HLA-DRB1
17 12.13 TNF IL6 IL10 IFNG
18 12.08 TLR4 HLA-DRB1 HLA-DQB1 HLA-B
19 12.02 TNF TLR4 IL6 IFNG
20 12.01 TNF KLRK1 IL6 IL5 IL10 IFNG
21 11.99 TNF IL6 IL17A IL10
22
Show member pathways
11.91 TNF TLR4 TLR2 IL6 IL17A IL10
23
Show member pathways
11.89 TLR4 TLR2 IL6 IL17A IFNG
24 11.81 TLR4 IL6 IL10 IFNG
25
Show member pathways
11.79 IL6 HLA-DRB1 CD8A
26 11.79 TNF IL6 IL10 IFNG CD8A
27 11.78 IL6 IL5 IFNG
28 11.77 TNF TLR4 IL6
29 11.77 IL6 IL5 IL10 IFNG
30 11.77 CD8A IFNG IL10 IL17A IL5 KLRK1
31 11.74 TNF TLR4 IL6 IL10 IFNG
32 11.73 IL6 IL17A IFNG
33
Show member pathways
11.72 TNF IL5 IFNG
34 11.72 IL10 IL6 TLR4 TNF
35 11.71 IL10 IL6 TLR4 TNF
36
Show member pathways
11.69 TNF IL6 IFNG
37 11.68 TNF IL6 IL5
38 11.66 IL5 IL10 CCL17
39 11.61 TNF TLR4 IL6 IFNG
40 11.57 TNF TLR4 TLR2 IFNG
41 11.56 TNF IL10 IFNG HLA-DRB1 HLA-DQB1
42 11.54 TNF IL6 IL10
43 11.53 CCL17 IFNG IL10 IL5
44 11.52 TNF IL6 IFNG
45 11.5 IL6 TLR4 TNF
46 11.44 HLA-DRB1 HLA-DQB1 HLA-B
48
Show member pathways
11.41 TNF IL10 IFNG
49 11.39 TNF TLR4 IL6 IL10
50 11.36 TNF IL6 IL5 IL17A IFNG

GO Terms for Echinococcosis

Cellular components related to Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.18 TNF TLR4 TLR2 KLRK1 HLA-DRB1 HLA-B
2 plasma membrane GO:0005887 10.18 TNF TLR4 TLR2 KLRK1 HLA-DRB1 HLA-B
3 external side of plasma membrane GO:0009897 9.73 CD8A HLA-DRB1 IL17A KLRK1 TLR4 TNF
4 extracellular space GO:0005615 9.62 TNF RNASE3 MIRLET7A1 MIR146A IL6 IL5

Biological processes related to Echinococcosis according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 10.41 CCL17 IL17A IL5 IL6 TLR2 TLR4
2 adaptive immune response GO:0002250 10.28 CD8A HLA-B HLA-DQB1 HLA-DRB1 IFNG IL17A
3 positive regulation of DNA-binding transcription factor activity GO:0051091 10.27 TNF IL6 IL5 IL10
4 positive regulation of inflammatory response GO:0050729 10.27 IFNG TLR2 TLR4 TNF
5 cellular response to type II interferon GO:0071346 10.25 CCL17 TLR2 TLR4 TNF
6 defense response to Gram-negative bacterium GO:0050829 10.23 TLR4 RNASE3 IL6 IL17A
7 positive regulation of tumor necrosis factor production GO:0032760 10.22 TLR4 TLR2 IL6 IL17A IFNG
8 positive regulation of interleukin-8 production GO:0032757 10.19 TNF TLR4 TLR2 IL6
9 regulation of insulin secretion GO:0050796 10.18 TNF IL6 IFNG
10 cellular response to lipopolysaccharide GO:0071222 10.18 TNF TLR4 MIR146A KLRK1 IL6 IL10
11 response to activity GO:0014823 10.17 TNF IL6 IL10
12 negative regulation of type II interferon production GO:0032689 10.16 HLA-DRB1 IL10 TLR4
13 positive regulation of interleukin-10 production GO:0032733 10.16 TLR4 TLR2 IL6
14 lipopolysaccharide-mediated signaling pathway GO:0031663 10.15 TNF TLR4 TLR2
15 positive regulation of interleukin-12 production GO:0032735 10.15 TLR4 TLR2 IL17A IFNG
16 liver regeneration GO:0097421 10.14 TNF IL6 IL10
17 positive regulation of nitric oxide biosynthetic process GO:0045429 10.14 IFNG KLRK1 TLR4 TNF
18 negative regulation of interleukin-6 production GO:0032715 10.13 TNF TLR4 MIR146A IL10
19 positive regulation of immunoglobulin production GO:0002639 10.12 IL6 IL5 IL10
20 microglial cell activation GO:0001774 10.12 TNF TLR2 IFNG
21 positive regulation of T cell mediated cytotoxicity GO:0001916 10.11 TAP2 HLA-DRB1 HLA-B
22 positive regulation of osteoclast differentiation GO:0045672 10.1 TNF IL17A IFNG
23 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.1 IL10 IL5 IL6 TNF
24 positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 10.09 TNF MIR146A IL10
25 cellular response to amyloid-beta GO:1904646 10.08 MIR146A TLR4 TNF
26 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 10.08 TLR4 TLR2 IFNG
27 positive regulation of interleukin-1 beta production GO:0032731 10.07 TNF TLR4 IL6 IL17A IFNG
28 immune system process GO:0002376 10.06 TLR4 TLR2 TAP2 KLRK1 IL17A HLA-DRB1
29 positive regulation of MHC class II biosynthetic process GO:0045348 10.05 TLR4 IL10 IFNG
30 defense response to Gram-positive bacterium GO:0050830 10.03 IL17A IL6 KLRK1 RNASE3 TLR2 TNF
31 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.01 TNF TLR4 IL6 IL17A
32 positive regulation of oxidative stress-induced neuron death GO:1903223 9.99 TNF TLR4
33 negative regulation of cytokine production involved in immune response GO:0002719 9.98 TNF IL10
34 intestinal epithelial structure maintenance GO:0060729 9.98 IL17A TLR4
35 humoral immune response GO:0006959 9.97 TNF IL6 IFNG HLA-DRB1 HLA-DQB1
36 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.96 TNF IFNG
37 positive regulation of nitrogen compound metabolic process GO:0051173 9.96 TNF IFNG
38 response to molecule of bacterial origin GO:0002237 9.96 TLR2 TAP2 IL10
39 positive regulation of matrix metallopeptidase secretion GO:1904466 9.93 TLR2 TLR4
40 chronic inflammatory response to antigenic stimulus GO:0002439 9.92 IL10 TNF
41 positive regulation of vitamin D biosynthetic process GO:0060557 9.91 IFNG TNF
42 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.91 TLR2 TLR4
43 antigen processing and presentation GO:0019882 9.91 CD8A HLA-B HLA-DQB1 HLA-DRB1
44 positive regulation of chemokine production GO:0032722 9.85 TNF TLR4 TLR2 IL6 IFNG
45 positive regulation of interleukin-6 production GO:0032755 9.73 IFNG IL17A IL6 TLR2 TLR4 TNF
46 immune response GO:0006955 9.64 TNF TLR4 TLR2 IL6 IL5 IL17A

Molecular functions related to Echinococcosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 9.73 TLR4 TLR2 RNASE3
2 MHC class I protein binding GO:0042288 9.63 TAP2 KLRK1 CD8A
3 lipopolysaccharide immune receptor activity GO:0001875 9.62 TLR4 TLR2
4 peptide antigen binding GO:0042605 9.5 TAP2 HLA-DRB1 HLA-DQB1 HLA-B
5 cytokine activity GO:0005125 9.44 TNF IL6 IL5 IL17A IL10 IFNG

Sources for Echinococcosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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