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MCID: ECH002
MIFTS: 40

Echolalia

Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Echolalia

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MalaCards integrated aliases for Echolalia:

Name: Echolalia 12 44 15 72

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4188
MeSH 44 D004454
NCIt 50 C97166
SNOMED-CT 68 64712007
UMLS 72 C0013528
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Summaries for Echolalia

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Disease Ontology : 12 A speech disorder that involves the automatic repetition of vocalizations made by another person.

MalaCards based summary : Echolalia is related to gilles de la tourette syndrome and schizophrenia, and has symptoms including photophobia, restlessness and scanning speech. An important gene associated with Echolalia is CDA (Cytidine Deaminase), and among its related pathways/superpathways are Beta-Adrenergic Signaling and Dopamine-DARPP32 Feedback onto cAMP Pathway. The drug Anesthetics has been mentioned in the context of this disorder. Affiliated tissues include brain, liver and cortex, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 75 Echolalia is the unsolicited repetition of vocalizations made by another person (by the same person is... more...

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Related Diseases for Echolalia

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Diseases related to Echolalia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 gilles de la tourette syndrome 32.9 DRD5 DRD4 DRD2
2 schizophrenia 29.5 DRD5 DRD4 DRD3 DRD2 DRD1 DISC1
3 autism spectrum disorder 11.6
4 chromosome 15q11-q13 duplication syndrome 11.2
5 frontotemporal dementia with parkinsonism-17 11.2
6 autism 10.6
7 aphasia 10.5
8 early-onset schizophrenia 10.4 DRD2 DRD1
9 schizophrenia 2 10.4 DRD3 DISC1
10 tic disorder 10.4 DRD5 DRD4 DRD2
11 polysubstance abuse 10.3 DRD3 DRD2
12 delusional disorder 10.3 DRD4 DRD3 DRD2
13 bruxism 10.3 DRD5 DRD3 DRD2
14 impulse control disorder 10.3 DRD4 DRD3 DRD2
15 conduct disorder 10.3 DRD5 DRD4 DRD2
16 migraine without aura 10.3 DRD4 DRD3 DRD2
17 schizoaffective disorder 10.3 DRD3 DRD2 DISC1
18 specific developmental disorder 10.2 FMR1 DRD5 DRD4
19 tremor 10.2 MAPT FMR1 DRD3
20 chromosome 16p13.3 deletion syndrome, proximal 10.2
21 apraxia 10.2
22 pathological gambling 10.1 DRD4 DRD3 DRD2 DRD1
23 substance abuse 10.1 DRD5 DRD4 DRD3 DRD2
24 mood disorder 10.1 DRD4 DRD3 DRD2 DISC1
25 substance dependence 10.1 DRD5 DRD4 DRD3 DRD2
26 obsessive-compulsive disorder 10.1 DRD4 DRD3 DRD2 DRD1
27 creutzfeldt-jakob disease 10.1
28 huntington disease 10.1
29 systemic lupus erythematosus 10.1
30 hyperlexia 10.1
31 supranuclear palsy, progressive, 1 10.1
32 chorea, childhood-onset, with psychomotor retardation 10.1
33 choreatic disease 10.1
34 mitral valve stenosis 10.1
35 status epilepticus 10.1
36 epilepsy 10.1
37 encephalomalacia 10.1
38 astrocytoma 10.1
39 germinoma 10.1
40 mutism 10.1
41 peripheral nervous system disease 10.1
42 neuropathy 10.1
43 lupus erythematosus 10.1
44 major depressive disorder 10.1 DRD4 DRD3 DRD2 DISC1
45 alcohol dependence 10.0 DRD4 DRD3 DRD2 DRD1
46 movement disease 10.0 MAPT FMR1 DRD3 DRD2
47 migraine with or without aura 1 10.0 DRD5 DRD3 DRD2
48 tardive dyskinesia 10.0 DRD3 DRD2
49 psychotic disorder 10.0 DRD4 DRD3 DRD2 DRD1 DISC1
50 attention deficit-hyperactivity disorder 9.7 FMR1 DRD5 DRD4 DRD3 DRD2 DRD1

Graphical network of the top 20 diseases related to Echolalia:



Diseases related to Echolalia
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Symptoms & Phenotypes for Echolalia

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UMLS symptoms related to Echolalia:


photophobia, restlessness, scanning speech, personality changes, pseudobulbar behavioral symptoms, sleep disturbances, other symbolic dysfunction, mental and behavioral signs and symptoms

MGI Mouse Phenotypes related to Echolalia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 ADD2 BHLHE22 CBSL DISC1 DRD1 DRD2
2 growth/size/body region MP:0005378 10.11 BHLHE22 CBSL DISC1 DRD1 DRD2 DRD3
3 homeostasis/metabolism MP:0005376 10.1 ADD2 CBSL DISC1 DRD1 DRD2 DRD3
4 cardiovascular system MP:0005385 10.06 ADD2 CBSL DRD1 DRD2 DRD3 DRD5
5 nervous system MP:0003631 9.97 ADD2 BHLHE22 CBSL DISC1 DRD1 DRD2
6 integument MP:0010771 9.91 BHLHE22 CBSL DRD1 DRD2 FMR1 IKBKG
7 renal/urinary system MP:0005367 9.5 ADD2 CBSL DRD2 DRD3 DRD5 ITGB3
8 vision/eye MP:0005391 9.23 BHLHE22 CBSL DRD1 DRD4 DRD5 FMR1
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Drugs & Therapeutics for Echolalia

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Drugs for Echolalia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Assessment Effects of Somatosensorial and Vestibular Rehabilitation Additional Conventional Therapy on Balance in Patients With Acute Stroke Completed NCT03477188
2 Prospective Treatment Study of Catatonia Patients With Right Unilateral Electroconvulsive Treatment (RUL ECT) and Bilateral Electroconvulsive Treatment (BL ECT) Regimens Terminated NCT02734498

Search NIH Clinical Center for Echolalia

Cochrane evidence based reviews: echolalia

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Genetic Tests for Echolalia

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Anatomical Context for Echolalia

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MalaCards organs/tissues related to Echolalia:

41
Brain, Liver, Cortex, Cingulate Cortex
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Publications for Echolalia

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Articles related to Echolalia:

(show top 50) (show all 247)
# Title Authors PMID Year
1
Elevated mirror neuron system activity in bipolar mania: Evidence from a transcranial magnetic stimulation study. 38
30422373 2019
2
Improvement of Post Stroke Echolalia after Using Selective Serotonin Reuptake Inhibitors. 38
31097970 2019
3
Repetitive verbal behaviors are not always harmful signs: Compensatory plasticity within the language network in aphasia. 38
30665003 2019
4
Gogi (Word Meaning) Aphasia and Its Relation with Semantic Dementia. 38
31220829 2019
5
Language as a Threat: Multimodal Evaluation and Interventions for Overwhelming Linguistic Anxiety in Severe Aphasia. 38
31133908 2019
6
Two Sides of the Same Coin: A Case Report of First-Episode Catatonic Syndrome in a High-Functioning Autism Patient. 38
31031660 2019
7
Focal Electrographic Seizures in a Patient With Autism Spectrum Disorder and Speech Delay. 38
30461592 2018
8
Being vs. Appearing Socially Uninterested: Challenging Assumptions about Social Motivation in Autism. 38
29914590 2018
9
Frontotemporal lobar degeneration due to P301L tau mutation showing apathy and severe frontal atrophy but lacking other behavioral changes: A case report and literature review. 38
29105852 2018
10
Pali and Echo Phenomena: Symptoms of Persistence and Perseveration. 38
29145181 2018
11
Catatonia Under-Diagnosis in the General Hospital. 38
29325478 2018
12
Autism spectrum disorders and disease modeling using stem cells. 38
28918504 2018
13
Jumping Frenchmen, Miryachit, and Latah: Culture-Specific Hyperstartle-Plus Syndromes. 38
29151096 2018
14
Non-Neurogenic Language Disorders: A Preliminary Classification. 38
28911819 2018
15
Intermittent catatonia and complex automatisms caused by frontal lobe epilepsy in dementia. 38
29237665 2017
16
A Neural Basis for Contagious Yawning. 38
28867202 2017
17
[German version of the Northoff catatonia rating scale (NCRS-dv) : A validated instrument for measuring catatonic symptoms]. 38
27325247 2017
18
Association between speech-language, general cognitive functioning and behaviour problems in individuals with Williams syndrome. 38
28612476 2017
19
Sign Language Echolalia in Deaf Children With Autism Spectrum Disorder. 38
28586822 2017
20
Identification of Two Heritable Cross-Disorder Endophenotypes for Tourette Syndrome. 38
27809572 2017
21
Posterior fossa syndrome with a large inflammatory ponto-mesencephalic lesion. 38
27842285 2017
22
Hashimoto's Encephalopathy Presenting with Unusual Behavioural Disturbances in an Adolescent Girl. 38
28607558 2017
23
Thinking on Treating Echolalia in Aphasia: Recommendations and Caveats for Future Research Directions. 38
28420974 2017
24
Unusual psychotic presentation after discontinuation of treatment in a patient with Wilson's disease: a case report. 38
27996315 2016
25
Validation of the Pediatric Catatonia Rating Scale (PCRS). 38
27377978 2016
26
PSP-CBS with Dopamine Deficiency in a Female with a FMR1 Premutation. 38
27230899 2016
27
A Multidimensional Reappraisal of Language in Autism: Insights from a Discourse Analytic Study. 38
26701673 2016
28
Language and Speech in Autism. 38
28127576 2016
29
[Catatonia is often overlooked in child and adolescent psychiatry]. 38
26750196 2016
30
Catatonia in Ugandan children with nodding syndrome and effects of treatment with lorazepam: a pilot study. 38
26710961 2015
31
Non-convulsive status epilepticus: a practical approach to diagnosis in confused older people. 38
26399267 2015
32
Examining the Echolalia Literature: Where Do Speech-Language Pathologists Stand? 38
26161804 2015
33
Gilles de la Tourette syndrome in a cohort of deaf people. 38
26216703 2015
34
[Echolalia and progressive supranuclear palsy, an unexpected association]. 38
26178519 2015
35
[Catatonia]. 38
25858694 2015
36
Acute Psychosis after Recent Isoniazid Initiation. 38
26266198 2015
37
Are there distinct subtypes in Tourette syndrome? Pure-Tourette syndrome versus Tourette syndrome-plus, and simple versus complex tics. 38
26089672 2015
38
The role of β3 integrin gene variants in Autism Spectrum Disorders--diagnosis and symptomatology. 38
25280596 2014
39
Acute toxicity associated with the recreational use of the novel dissociative psychoactive substance methoxphenidine. 38
25350467 2014
40
Preliminary findings of similarities and differences in the signed and spoken language of children with autism. 38
25321855 2014
41
[Introduction and transformation of the psychiatric term "anancasm". From Gyula (Julius) Donáth via Kurt Schneider to ICD-10]. 38
24036702 2014
42
Electroconvulsive therapy for catatonia in juvenile neuropsychiatric lupus. 38
24786782 2014
43
Rethinking echolalia: repetition as interactional resource in the communication of a child with autism. 38
23469804 2014
44
Catatonia in patients with autism: prevalence and management. 38
24504828 2014
45
Anti-N-methyl-D-aspartate receptor-mediated encephalitis in infants and toddlers: case report and review of the literature. 38
24315538 2014
46
Echothymia: environmental dependency in the affective domain. 38
24515681 2014
47
On the intersection of phonetic detail and the organization of interaction: clinical connections. 38
24067088 2013
48
Quantifying repetitive speech in autism spectrum disorders and language impairment. 38
23661504 2013
49
On the differential nature of induced and incidental echolalia in autism. 38
22676294 2013
50
Cavum septum pellucidum and cavum vergae with late-onset catatonia. 38
23670024 2013
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Variations for Echolalia

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Expression for Echolalia

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Search GEO for disease gene expression data for Echolalia.
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Pathways for Echolalia

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Pathways related to Echolalia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Beta-Adrenergic Signaling 64
Show member pathways
 12.4 MAPT ITGB3 DRD5 DRD4 DRD3 DRD2
2
Dopamine-DARPP32 Feedback onto cAMP Pathway 64
12.01 DRD5 DRD4 DRD3 DRD2 DRD1
4
Long-term potentiation 37
Show member pathways
 11.84 DRD5 DRD4 DRD2 DRD1
5
Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics 61
Show member pathways
 11.59 DRD4 DRD3 DRD2
6
Monoamine GPCRs 1
Show member pathways
 11.4 DRD5 DRD4 DRD3 DRD2 DRD1
7
DARPP-32 Phosphorylation 65
10.27 DRD5 DRD3 DRD2 DRD1
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GO Terms for Echolalia

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Cellular components related to Echolalia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 postsynaptic density GO:0014069 9.71 FMR1 DRD2 DISC1 ADD2
2 GABA-ergic synapse GO:0098982 9.43 DRD3 DRD2 DRD1
3 dopaminergic synapse GO:0098691 9.37 DRD3 DRD2
4 glutamatergic synapse GO:0098978 9.35 ITGB3 DRD4 DRD3 DRD2 DRD1
5 ciliary membrane GO:0060170 9.33 DRD5 DRD2 DRD1
6 glial cell projection GO:0097386 9.32 MAPT FMR1
7 non-motile cilium GO:0097730 8.8 DRD5 DRD2 DRD1

Biological processes related to Echolalia according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.98 LGALS1 DRD3 DRD2 DRD1
2 cellular calcium ion homeostasis GO:0006874 9.85 DRD5 DRD4 DRD3
3 locomotory behavior GO:0007626 9.83 DRD3 DRD2 DRD1
4 synapse assembly GO:0007416 9.81 DRD2 DRD1 ADD2
5 visual learning GO:0008542 9.79 DRD3 DRD2 DRD1
6 associative learning GO:0008306 9.76 DRD5 DRD2 DRD1
7 response to cocaine GO:0042220 9.76 DRD5 DRD3 DRD2 DRD1
8 negative regulation of blood pressure GO:0045776 9.75 DRD5 DRD3 DRD2
9 arachidonic acid secretion GO:0050482 9.73 DRD4 DRD3 DRD2
10 negative regulation of protein secretion GO:0050709 9.72 DRD4 DRD3 DRD2
11 prepulse inhibition GO:0060134 9.71 DRD3 DRD2 DRD1
12 regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 9.7 ITGB3 DRD4 DRD3
13 positive regulation of receptor internalization GO:0002092 9.69 FMR1 DRD2
14 positive regulation of neuroblast proliferation GO:0002052 9.69 DRD2 DISC1
15 temperature homeostasis GO:0001659 9.69 DRD2 DRD1
16 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.69 DRD4 DRD3 DRD2
17 transmission of nerve impulse GO:0019226 9.68 DRD5 DRD1
18 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.68 DRD3 DRD2
19 long-term synaptic depression GO:0060292 9.68 DRD5 DRD1
20 striatum development GO:0021756 9.67 DRD2 DRD1
21 positive regulation of renal sodium excretion GO:0035815 9.67 DRD3 DRD2
22 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.67 DRD5 DRD3 DRD1
23 grooming behavior GO:0007625 9.66 DRD2 DRD1
24 G protein-coupled receptor internalization GO:0002031 9.65 DRD3 DRD2
25 regulation of dopamine metabolic process GO:0042053 9.65 DRD4 DRD1
26 peristalsis GO:0030432 9.65 DRD2 DRD1
27 negative regulation of voltage-gated calcium channel activity GO:1901386 9.65 FMR1 DRD4 DRD2
28 behavioral response to ethanol GO:0048149 9.64 DRD4 DRD2
29 mating behavior GO:0007617 9.64 DRD5 DRD1
30 cellular response to catecholamine stimulus GO:0071870 9.63 DRD5 DRD1
31 cerebral cortex GABAergic interneuron migration GO:0021853 9.62 DRD2 DRD1
32 behavioral response to cocaine GO:0048148 9.62 DRD4 DRD3 DRD2 DRD1
33 negative regulation of dopamine receptor signaling pathway GO:0060160 9.61 DRD3 DRD2
34 regulation of locomotion involved in locomotory behavior GO:0090325 9.61 DRD3 DRD2
35 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.61 DRD5 DRD2 DRD1
36 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 9.6 DRD4 DRD2
37 acid secretion GO:0046717 9.59 DRD3 DRD2
38 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.58 DRD3 DRD2 DRD1
39 sensitization GO:0046960 9.57 DRD5 DRD1
40 synaptic transmission, dopaminergic GO:0001963 9.56 DRD5 DRD3 DRD2 DRD1
41 response to histamine GO:0034776 9.54 DRD4 DRD3 DRD2
42 dopamine receptor signaling pathway GO:0007212 9.46 DRD4 DRD3 DRD2 DRD1
43 dopamine metabolic process GO:0042417 9.26 DRD4 DRD3 DRD2 DRD1
44 response to amphetamine GO:0001975 9.02 DRD5 DRD4 DRD3 DRD2 DRD1

Molecular functions related to Echolalia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.91 MAPT ITGB3 IKBKG FMR1 DRD4 DRD2
2 protein homodimerization activity GO:0042803 9.87 MAPT LGALS1 IKBKG FMR1 DRD2 CDA
3 drug binding GO:0008144 9.58 DRD4 DRD3 DRD2
4 G-protein alpha-subunit binding GO:0001965 9.46 DRD5 DRD1
5 adrenergic receptor activity GO:0004935 9.43 DRD3 DRD2
6 dopamine binding GO:0035240 9.35 DRD5 DRD4 DRD3 DRD2 DRD1
7 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.33 DRD4 DRD3 DRD2
8 dopamine neurotransmitter receptor activity, coupled via Gs GO:0001588 9.26 DRD5 DRD1
9 dopamine neurotransmitter receptor activity GO:0004952 9.02 DRD5 DRD4 DRD3 DRD2 DRD1
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Sources for Echolalia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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