Aliases & Classifications for Echolalia

MalaCards integrated aliases for Echolalia:

Name: Echolalia 12 45 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4188
MeSH 45 D004454
NCIt 51 C97166
SNOMED-CT 69 64712007
UMLS 74 C0013528

Summaries for Echolalia

Disease Ontology : 12 A speech disorder that involves the automatic repetition of vocalizations made by another person.

MalaCards based summary : Echolalia is related to gilles de la tourette syndrome and autism, and has symptoms including photophobia, restlessness and scanning speech. An important gene associated with Echolalia is CDA (Cytidine Deaminase), and among its related pathways/superpathways are Circadian entrainment and Beta-Adrenergic Signaling. The drugs Verapamil and Calcium have been mentioned in the context of this disorder. Affiliated tissues include cortex, liver and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Echolalia is defined as the unsolicited repetition of vocalizations made by another person (by the same... more...

Related Diseases for Echolalia

Diseases related to Echolalia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 gilles de la tourette syndrome 32.5 DRD2 DRD4 DRD5
2 autism 10.4
3 schizophrenia 2 10.2 DISC1 DRD3
4 aphasia 10.2
5 early-onset schizophrenia 10.2 DRD1 DRD2
6 tic disorder 10.2 DRD2 DRD4 DRD5
7 bruxism 10.1 DRD2 DRD3 DRD5
8 delusional disorder 10.1 DRD2 DRD3 DRD4
9 polysubstance abuse 10.1 DRD2 DRD3
10 stroke, ischemic 10.1
11 chromosome 16p13.3 deletion syndrome, proximal 10.1
12 impulse control disorder 10.1 DRD2 DRD3 DRD4
13 conduct disorder 10.1 DRD2 DRD4 DRD5
14 migraine without aura 10.1 DRD2 DRD3 DRD4
15 schizoaffective disorder 10.1 DISC1 DRD2 DRD3
16 specific developmental disorder 10.1 DRD4 DRD5 FMR1
17 migraine with or without aura 1 10.0 DRD2 DRD3 DRD5
18 tremor 10.0 DRD3 FMR1 MAPT
19 tardive dyskinesia 10.0 DRD2 DRD3
20 pathological gambling 10.0 DRD1 DRD2 DRD3 DRD4
21 substance abuse 10.0 DRD2 DRD3 DRD4 DRD5
22 mood disorder 10.0 DISC1 DRD2 DRD3 DRD4
23 substance dependence 10.0 DRD2 DRD3 DRD4 DRD5
24 alcohol abuse 10.0 DRD1 DRD2 DRD3 DRD4
25 creutzfeldt-jakob disease 10.0
26 huntington disease 10.0
27 systemic lupus erythematosus 10.0
28 hyperlexia 10.0
29 autism spectrum disorder 10.0
30 mitral valve stenosis 10.0
31 status epilepticus 10.0
32 epilepsy 10.0
33 germinoma 10.0
34 lupus erythematosus 10.0
35 obsessive-compulsive disorder 10.0 DRD1 DRD2 DRD3 DRD4
36 major depressive disorder 10.0 DISC1 DRD2 DRD3 DRD4
37 alcohol dependence 9.9 DRD1 DRD2 DRD3 DRD4
38 heroin dependence 9.9 DRD2 DRD4
39 movement disease 9.9 DRD2 DRD3 FMR1 MAPT
40 psychotic disorder 9.9 DISC1 DRD1 DRD2 DRD3 DRD4
41 parkinson disease, late-onset 9.7 DRD1 DRD2 DRD3 MAPT
42 schizophrenia 9.7 DISC1 DRD1 DRD2 DRD3 DRD4 DRD5
43 attention deficit-hyperactivity disorder 9.7 DRD1 DRD2 DRD3 DRD4 DRD5 FMR1
44 disease of mental health 9.6 DISC1 DRD2 DRD3 DRD4 FMR1 MAPT

Graphical network of the top 20 diseases related to Echolalia:



Diseases related to Echolalia

Symptoms & Phenotypes for Echolalia

UMLS symptoms related to Echolalia:


photophobia, restlessness, scanning speech, personality changes, pseudobulbar behavioral symptoms, sleep disturbances, other symbolic dysfunction, mental and behavioral signs and symptoms

GenomeRNAi Phenotypes related to Echolalia according to GeneCards Suite gene sharing:

27 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.77 IKBKG
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.77 IRGC
3 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.77 DRD2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.77 IRGC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.77 DRD4
6 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.77 DRD4 IKBKG
7 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.77 DRD4
8 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.77 IRGC
9 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.77 DRD2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-172 9.77 DRD4
11 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.77 DRD2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.77 DRD2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.77 IKBKG IRGC
14 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.77 IKBKG
15 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.77 CDA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.77 IKBKG
17 Increased shRNA abundance (Z-score > 2) GR00366-A-51 9.77 IRGC
18 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.77 CDA DRD2 DRD4 IKBKG IRGC
19 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.77 DRD2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.77 IRGC
21 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.77 IRGC
22 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.77 DRD2

MGI Mouse Phenotypes related to Echolalia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.23 ADD2 CBSL DISC1 DRD1 DRD2 DRD3
2 growth/size/body region MP:0005378 10.1 CBSL DISC1 DRD1 DRD2 DRD3 FMR1
3 homeostasis/metabolism MP:0005376 10.1 ADD2 CBSL DISC1 DRD1 DRD2 DRD3
4 cardiovascular system MP:0005385 10.09 ADD2 CBSL DRD1 DRD2 DRD3 DRD5
5 hematopoietic system MP:0005397 10.02 ADD2 CBSL DISC1 DRD1 DRD2 DUSP4
6 nervous system MP:0003631 9.93 ADD2 CBSL DISC1 DRD1 DRD2 DRD3
7 integument MP:0010771 9.86 CBSL DRD1 DRD2 FMR1 IKBKG ITGB3
8 renal/urinary system MP:0005367 9.5 ADD2 CBSL DRD2 DRD3 DRD5 ITGB3
9 vision/eye MP:0005391 9.17 CBSL DRD1 DRD4 DRD5 FMR1 ITGB3

Drugs & Therapeutics for Echolalia

Drugs for Echolalia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Verapamil Approved Phase 2 52-53-9 2520
2
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
3 Calcium, Dietary Phase 2
4 Anti-Arrhythmia Agents Phase 2
5 Vasodilator Agents Phase 2
6 Hormones Phase 2
7 calcium channel blockers Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sapropterin as a Treatment for Autistic Disorder Completed NCT00850070 Phase 2 sapropterin;Placebo

Search NIH Clinical Center for Echolalia

Cochrane evidence based reviews: echolalia

Genetic Tests for Echolalia

Anatomical Context for Echolalia

MalaCards organs/tissues related to Echolalia:

42
Cortex, Liver, Brain, Cingulate Cortex

Publications for Echolalia

Articles related to Echolalia:

(show top 50) (show all 57)
# Title Authors Year
1
Improvement of Post Stroke Echolalia after Using Selective Serotonin Reuptake Inhibitors. ( 31097970 )
2019
2
Sign Language Echolalia in Deaf Children With Autism Spectrum Disorder. ( 28586822 )
2017
3
Thinking on Treating Echolalia in Aphasia: Recommendations and Caveats for Future Research Directions. ( 28420974 )
2017
4
Examining the Echolalia Literature: Where Do Speech-Language Pathologists Stand? ( 26161804 )
2015
5
Rethinking echolalia: repetition as interactional resource in the communication of a child with autism. ( 23469804 )
2014
6
On the differential nature of induced and incidental echolalia in autism. ( 22676294 )
2013
7
Ambient echolalia in a patient with germinoma around the bilateral ventriculus lateralis: a case report. ( 22117108 )
2012
8
The pathophysiology of echopraxia/echolalia: relevance to Gilles de la Tourette syndrome. ( 22807284 )
2012
9
Echolalia or functional repetition in conversation--a case study of an individual with Huntington's disease. ( 20831380 )
2011
10
Echocardiographic investigations of myocardial function in mitral stenosis: making sense of the echolalia. ( 21952160 )
2011
11
Verbal repetitions and echolalia in Alzheimer's discourse. ( 20964503 )
2010
12
Palilalia, echolalia, and echopraxia-palipraxia as ictal manifestations in a patient with left frontal lobe epilepsy. ( 19175395 )
2009
13
Hyperlexia and ambient echolalia in a case of cerebral infarction of the left anterior cingulate cortex and corpus callosum. ( 19585352 )
2009
14
Echolalia in the language development of autistic individuals: a bibliographical review. ( 19838574 )
2009
15
The emergence of echolalia while taking sertraline in a patient with Tourette's syndrome. ( 18481372 )
2008
16
Postoperative echolalia and catatonia responsive to gamma aminobutyric acid receptor agonists in a liver transplant patient. ( 16931705 )
2006
17
Echolalia in a liver transplant recipient. ( 15316384 )
2004
18
Chronic 'speech catatonia' with constant logorrhea, verbigeration and echolalia successfully treated with lorazepam: a case report. ( 15601393 )
2004
19
Prominent echolalia from isolation of the speech area. ( 12154164 )
2002
20
Echolalia as a novel manifestation of neuropsychiatric systemic lupus erythematosus. ( 11213948 )
2001
21
Echolalia-palilalia as the sole manifestation of nonconvulsive status epilepticus. ( 10980752 )
2000
22
Brief report: treatment of echolalia in a girl with Rubinstein-Taybi syndrome: functional assessment of minimizing chances to provoke echolalia. ( 9932244 )
1998
23
Effortful echolalia. ( 9533994 )
1998
24
Study of a nervous disorder characterized by motor incoordination with echolalia and coprolalia (The introduction and case studies of Gilles de la Tourette's 1885 paper). ( 11620011 )
1998
25
Teaching receptive naming of Chinese characters to children with autism by incorporating echolalia. ( 9157099 )
1997
26
Effects of high and low constraint utterances on the production of immediate and delayed echolalia in young children with autism. ( 7844096 )
1994
27
Creutzfeldt-Jakob disease with mixed transcortical aphasia: insights into echolalia. ( 24487337 )
1994
28
Evolution of technetium-99m-HMPAO SPECT and brain mapping in a patient presenting with echolalia and palilalia. ( 1869990 )
1991
29
The effects of two levels of linguistic constraint on echolalia and generative language production in children with autism. ( 1864826 )
1991
30
Long-term follow-up of echolalia and question answering. ( 2249974 )
1990
31
Echolalia and comprehension in autistic children. ( 2745392 )
1989
32
The functions of immediate echolalia in autistic children: a developmental perspective. ( 3215891 )
1988
33
Setting effects on the occurrence of autistic children's immediate echolalia. ( 3804960 )
1986
34
Some direct and generalized effects of replacing an autistic man's echolalia with correct responses to questions. ( 3771422 )
1986
35
Immediate echolalia and the interactive behaviour of autistic children. ( 3832444 )
1985
36
Analysis of functions of delayed echolalia in autistic children. ( 6738028 )
1984
37
The effects of echolalia on acquisition and generalization of receptive labeling in autistic children. ( 6833164 )
1983
38
Medical writing: Echolalia. ( 7152728 )
1982
39
Language processing and forms of immediate echolalia in autistic children. ( 7087424 )
1982
40
Delayed echolalia in autism: some observations on differences within the term. ( 7326840 )
1981
41
Response sets in autistic echolalia. ( 7290887 )
1981
42
The functions of immediate echolalia in autistic children. ( 7278167 )
1981
43
Echolalia: issues and clinical applications. ( 390245 )
1979
44
Control of selective echolalia via the instatement of a general alternative response. ( 718598 )
1978
45
Social and attentional aspects of echolalia in highly echolalic mentally retarded persons. ( 623163 )
1978
46
Late onset echolalia in autism and allied disorders. ( 857834 )
1977
47
[Transcortical aphasia and echolalia; problems of speech initiative]. ( 1188237 )
1975
48
Semantic considerations in the treatment of echolalia. ( 1177772 )
1975
49
On some language parameters of autistic echolalia. ( 4459628 )
1974
50
On the echolalia of the blind and of the autistic child. ( 4754881 )
1973

Variations for Echolalia

Expression for Echolalia

Search GEO for disease gene expression data for Echolalia.

Pathways for Echolalia

GO Terms for Echolalia

Cellular components related to Echolalia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.91 DRD1 DRD2 DRD3 DRD4 DRD5 GABRR3
2 postsynaptic density GO:0014069 9.71 ADD2 DISC1 DRD2 FMR1
3 dendritic spine GO:0043197 9.65 DRD2 FMR1 MAPT
4 dopaminergic synapse GO:0098691 9.43 DRD2 DRD3
5 GABA-ergic synapse GO:0098982 9.43 DRD1 DRD2 DRD3
6 glutamatergic synapse GO:0098978 9.35 DRD1 DRD2 DRD3 DRD4 ITGB3
7 ciliary membrane GO:0060170 9.33 DRD1 DRD2 DRD5
8 glial cell projection GO:0097386 9.32 FMR1 MAPT
9 non-motile cilium GO:0097730 8.8 DRD1 DRD2 DRD5
10 plasma membrane GO:0005886 10.2 ADD2 DISC1 DRD1 DRD2 DRD3 DRD4

Biological processes related to Echolalia according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.98 DRD1 DRD2 DRD3 LGALS1
2 cellular calcium ion homeostasis GO:0006874 9.85 DRD3 DRD4 DRD5
3 locomotory behavior GO:0007626 9.83 DRD1 DRD2 DRD3
4 synapse assembly GO:0007416 9.81 ADD2 DRD1 DRD2
5 visual learning GO:0008542 9.79 DRD1 DRD2 DRD3
6 associative learning GO:0008306 9.76 DRD1 DRD2 DRD5
7 response to cocaine GO:0042220 9.76 DRD1 DRD2 DRD3 DRD5
8 negative regulation of blood pressure GO:0045776 9.75 DRD2 DRD3 DRD5
9 arachidonic acid secretion GO:0050482 9.73 DRD2 DRD3 DRD4
10 negative regulation of protein secretion GO:0050709 9.72 DRD2 DRD3 DRD4
11 prepulse inhibition GO:0060134 9.71 DRD1 DRD2 DRD3
12 regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 9.7 DRD3 DRD4 ITGB3
13 positive regulation of receptor internalization GO:0002092 9.69 DRD2 FMR1
14 positive regulation of neuroblast proliferation GO:0002052 9.69 DISC1 DRD2
15 temperature homeostasis GO:0001659 9.69 DRD1 DRD2
16 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.69 DRD1 DRD3 DRD5
17 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.68 DRD2 DRD3
18 transmission of nerve impulse GO:0019226 9.68 DRD1 DRD5
19 long-term synaptic depression GO:0060292 9.68 DRD1 DRD5
20 striatum development GO:0021756 9.67 DRD1 DRD2
21 grooming behavior GO:0007625 9.67 DRD1 DRD2
22 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.67 DRD2 DRD3 DRD4
23 positive regulation of renal sodium excretion GO:0035815 9.66 DRD2 DRD3
24 G protein-coupled receptor internalization GO:0002031 9.65 DRD2 DRD3
25 peristalsis GO:0030432 9.65 DRD1 DRD2
26 regulation of dopamine metabolic process GO:0042053 9.65 DRD1 DRD4
27 negative regulation of voltage-gated calcium channel activity GO:1901386 9.65 DRD2 DRD4 FMR1
28 behavioral response to ethanol GO:0048149 9.64 DRD2 DRD4
29 mating behavior GO:0007617 9.64 DRD1 DRD5
30 cellular response to catecholamine stimulus GO:0071870 9.63 DRD1 DRD5
31 cerebral cortex GABAergic interneuron migration GO:0021853 9.62 DRD1 DRD2
32 behavioral response to cocaine GO:0048148 9.62 DRD1 DRD2 DRD3 DRD4
33 negative regulation of dopamine receptor signaling pathway GO:0060160 9.61 DRD2 DRD3
34 acid secretion GO:0046717 9.61 DRD2 DRD3
35 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.61 DRD1 DRD2 DRD5
36 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 9.6 DRD2 DRD4
37 regulation of locomotion involved in locomotory behavior GO:0090325 9.59 DRD2 DRD3
38 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.58 DRD1 DRD2 DRD3
39 sensitization GO:0046960 9.57 DRD1 DRD5
40 dopamine receptor signaling pathway GO:0007212 9.56 DRD1 DRD2 DRD3 DRD4
41 response to histamine GO:0034776 9.54 DRD2 DRD3 DRD4
42 synaptic transmission, dopaminergic GO:0001963 9.46 DRD1 DRD2 DRD3 DRD5
43 dopamine metabolic process GO:0042417 9.26 DRD1 DRD2 DRD3 DRD4
44 response to amphetamine GO:0001975 9.02 DRD1 DRD2 DRD3 DRD4 DRD5

Molecular functions related to Echolalia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.91 CDA DRD2 DRD4 FMR1 IKBKG ITGB3
2 G protein-coupled receptor activity GO:0004930 9.88 DRD1 DRD2 DRD3 DRD4 DRD5
3 protein homodimerization activity GO:0042803 9.87 ADD2 CDA DRD2 FMR1 IKBKG LGALS1
4 drug binding GO:0008144 9.58 DRD2 DRD3 DRD4
5 G-protein alpha-subunit binding GO:0001965 9.46 DRD1 DRD5
6 adrenergic receptor activity GO:0004935 9.43 DRD2 DRD3
7 dopamine binding GO:0035240 9.35 DRD1 DRD2 DRD3 DRD4 DRD5
8 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.33 DRD2 DRD3 DRD4
9 dopamine neurotransmitter receptor activity, coupled via Gs GO:0001588 9.26 DRD1 DRD5
10 dopamine neurotransmitter receptor activity GO:0004952 9.02 DRD1 DRD2 DRD3 DRD4 DRD5

Sources for Echolalia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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