Aliases & Classifications for Echolalia

MalaCards integrated aliases for Echolalia:

Name: Echolalia 12 29 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4188
MeSH 44 D004454
NCIt 50 C97166
SNOMED-CT 68 64712007
UMLS 73 C0013528

Summaries for Echolalia

Disease Ontology : 12 A speech disorder that involves the automatic repetition of vocalizations made by another person.

MalaCards based summary : Echolalia is related to aphasia and gilles de la tourette syndrome, and has symptoms including sleep disturbances, photophobia and mental and behavioral signs and symptoms. An important gene associated with Echolalia is GRN (Granulin Precursor). The drugs Verapamil and Anti-Arrhythmia Agents have been mentioned in the context of this disorder. Affiliated tissues include liver, cortex and brain, and related phenotypes are behavior/neurological and immune system

Wikipedia : 76 Echolalia (also known as echologia or echophrasia) is defined as the unsolicited repetition of... more...

Related Diseases for Echolalia

Diseases related to Echolalia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 aphasia 30.3 GRN MAPT PSEN1
2 gilles de la tourette syndrome 11.4
3 phonagnosia 10.6 GRN PSEN1
4 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 10.6 GRN MAPT
5 associative agnosia 10.6 GRN PSEN1
6 writing disorder 10.5 GRN PSEN1
7 prosopagnosia 10.5 GRN PSEN1
8 pedophilia 10.4 GRN IRGC
9 gait apraxia 10.3 CBS GRN PSEN1
10 familial idiopathic basal ganglia calcification 10.3 MAPT PSEN1
11 progressive non-fluent aphasia 10.3 GRN MAPT PSEN1
12 behavioral variant of frontotemporal dementia 10.3 GRN MAPT PSEN1
13 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 10.3 CBS GRN PSEN1
14 semantic dementia 10.3 GRN MAPT PSEN1
15 autism 10.3
16 exhibitionism 10.3 ADD2 CBS
17 visual agnosia 10.2 GRN PSEN1
18 pick disease of brain 10.2 GRN MAPT PSEN1
19 specific developmental disorder 10.2 FMR1 GRN PSEN1
20 kluver-bucy syndrome 10.2 MAPT PSEN1
21 apraxia 10.2 GRN MAPT PSEN1
22 central nervous system disease 10.1 GRN MAPT PSEN1
23 nervous system disease 10.1 GRN MAPT PSEN1
24 agraphia 10.0 CBS GRN MAPT PSEN1
25 ideomotor apraxia 10.0 CBS GRN MAPT PSEN1
26 nominal aphasia 10.0 CBS GRN MAPT PSEN1
27 basal ganglia disease 10.0 CBS GRN MAPT PSEN1
28 supranuclear palsy, progressive, 1 10.0 CBS GRN MAPT PSEN1
29 dementia, lewy body 10.0 CBS GRN MAPT PSEN1
30 speech and communication disorders 10.0 CBS GRN MAPT PSEN1
31 chromosome 16p13.3 deletion syndrome, proximal 10.0
32 disease of mental health 9.9 FMR1 GRN MAPT PSEN1
33 paraphilia disorder 9.9 ADD2 CBS GRN IRGC
34 systemic lupus erythematosus 9.8
35 hyperlexia 9.8
36 stroke, ischemic 9.8
37 autism spectrum disorder 9.8
38 status epilepticus 9.8
39 epilepsy 9.8
40 cerebritis 9.8
41 lupus erythematosus 9.8
42 alzheimer disease 2 9.8 MAPT PSEN1
43 frontotemporal dementia 9.7 GRN MAPT PSEN1

Graphical network of the top 20 diseases related to Echolalia:



Diseases related to Echolalia

Symptoms & Phenotypes for Echolalia

UMLS symptoms related to Echolalia:


sleep disturbances, photophobia, mental and behavioral signs and symptoms, personality changes, scanning speech, other symbolic dysfunction, restlessness, pseudobulbar behavioral symptoms

MGI Mouse Phenotypes related to Echolalia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.92 BHLHE22 PSEN1 FMR1 GRN IKBKG LGALS1
2 immune system MP:0005387 9.86 ADD2 MAPT PSEN1 DUSP4 GRN IKBKG
3 integument MP:0010771 9.7 BHLHE22 PSEN1 FMR1 IKBKG ITGB3 LGALS1
4 nervous system MP:0003631 9.56 ADD2 MAPT BHLHE22 PSEN1 FMR1 GRN
5 vision/eye MP:0005391 9.1 MAPT BHLHE22 PSEN1 FMR1 GRN ITGB3

Drugs & Therapeutics for Echolalia

Drugs for Echolalia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Verapamil Approved Phase 2 52-53-9 2520
2 Anti-Arrhythmia Agents Phase 2
3 calcium channel blockers Phase 2
4 Calcium, Dietary Phase 2
5 Vasodilator Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sapropterin as a Treatment for Autistic Disorder Completed NCT00850070 Phase 2 sapropterin;Placebo

Search NIH Clinical Center for Echolalia

Cochrane evidence based reviews: echolalia

Genetic Tests for Echolalia

Genetic tests related to Echolalia:

# Genetic test Affiliating Genes
1 Echolalia 29

Anatomical Context for Echolalia

MalaCards organs/tissues related to Echolalia:

41
Liver, Cortex, Brain, Cingulate Cortex

Publications for Echolalia

Articles related to Echolalia:

(show top 50) (show all 54)
# Title Authors Year
1
Sign Language Echolalia in Deaf Children With Autism Spectrum Disorder. ( 28586822 )
2017
2
Thinking on Treating Echolalia in Aphasia: Recommendations and Caveats for Future Research Directions. ( 28420974 )
2017
3
Examining the Echolalia Literature: Where Do Speech-Language Pathologists Stand? ( 26161804 )
2015
4
Rethinking echolalia: repetition as interactional resource in the communication of a child with autism. ( 23469804 )
2013
5
On the differential nature of induced and incidental echolalia in autism. ( 22676294 )
2013
6
The pathophysiology of echopraxia/echolalia: relevance to Gilles de la Tourette syndrome. ( 22807284 )
2012
7
Ambient echolalia in a patient with germinoma around the bilateral ventriculus lateralis: a case report. ( 22117108 )
2012
8
Echolalia or functional repetition in conversation--a case study of an individual with Huntington's disease. ( 20831380 )
2011
9
Echocardiographic investigations of myocardial function in mitral stenosis: making sense of the echolalia. ( 21952160 )
2011
10
Verbal repetitions and echolalia in Alzheimer's discourse. ( 20964503 )
2010
11
Echolalia in the language development of autistic individuals: a bibliographical review. ( 19838574 )
2009
12
Hyperlexia and ambient echolalia in a case of cerebral infarction of the left anterior cingulate cortex and corpus callosum. ( 19585352 )
2009
13
Palilalia, echolalia, and echopraxia-palipraxia as ictal manifestations in a patient with left frontal lobe epilepsy. ( 19175395 )
2009
14
The emergence of echolalia while taking sertraline in a patient with Tourette's syndrome. ( 18481372 )
2008
15
Postoperative echolalia and catatonia responsive to gamma aminobutyric acid receptor agonists in a liver transplant patient. ( 16931705 )
2006
16
Chronic 'speech catatonia' with constant logorrhea, verbigeration and echolalia successfully treated with lorazepam: a case report. ( 15601393 )
2004
17
Echolalia in a liver transplant recipient. ( 15316384 )
2004
18
Prominent echolalia from isolation of the speech area. ( 12154164 )
2002
19
Echolalia as a novel manifestation of neuropsychiatric systemic lupus erythematosus. ( 11213948 )
2001
20
Echolalia-palilalia as the sole manifestation of nonconvulsive status epilepticus. ( 10980752 )
2000
21
Effortful echolalia. ( 9533994 )
1998
22
Study of a nervous disorder characterized by motor incoordination with echolalia and coprolalia (The introduction and case studies of Gilles de la Tourette's 1885 paper). ( 11620011 )
1998
23
Brief report: treatment of echolalia in a girl with Rubinstein-Taybi syndrome: functional assessment of minimizing chances to provoke echolalia. ( 9932244 )
1998
24
Teaching receptive naming of Chinese characters to children with autism by incorporating echolalia. ( 9157099 )
1997
25
Effects of high and low constraint utterances on the production of immediate and delayed echolalia in young children with autism. ( 7844096 )
1994
26
Evolution of technetium-99m-HMPAO SPECT and brain mapping in a patient presenting with echolalia and palilalia. ( 1869990 )
1991
27
The effects of two levels of linguistic constraint on echolalia and generative language production in children with autism. ( 1864826 )
1991
28
Long-term follow-up of echolalia and question answering. ( 2249974 )
1990
29
Echolalia and comprehension in autistic children. ( 2745392 )
1989
30
The functions of immediate echolalia in autistic children: a developmental perspective. ( 3215891 )
1988
31
Setting effects on the occurrence of autistic children's immediate echolalia. ( 3804960 )
1986
32
Some direct and generalized effects of replacing an autistic man's echolalia with correct responses to questions. ( 3771422 )
1986
33
Immediate echolalia and the interactive behaviour of autistic children. ( 3832444 )
1985
34
The effects of echolalia on acquisition and generalization of receptive labeling in autistic children. ( 6833164 )
1983
35
Medical writing: Echolalia. ( 7152728 )
1982
36
Language processing and forms of immediate echolalia in autistic children. ( 7087424 )
1982
37
The functions of immediate echolalia in autistic children. ( 7278167 )
1981
38
Delayed echolalia in autism: some observations on differences within the term. ( 7326840 )
1981
39
Response sets in autistic echolalia. ( 7290887 )
1981
40
Echolalia: issues and clinical applications. ( 390245 )
1979
41
Social and attentional aspects of echolalia in highly echolalic mentally retarded persons. ( 623163 )
1978
42
Control of selective echolalia via the instatement of a general alternative response. ( 718598 )
1978
43
Late onset echolalia in autism and allied disorders. ( 857834 )
1977
44
[Transcortical aphasia and echolalia; problems of speech initiative]. ( 1188237 )
1975
45
Semantic considerations in the treatment of echolalia. ( 1177772 )
1975
46
On some language parameters of autistic echolalia. ( 4459628 )
1974
47
On the echolalia of the blind and of the autistic child. ( 4754881 )
1973
48
On echolalia, echo-answer, and contamination. ( 5001522 )
1971
49
Echolalia, IQ, and the developmental dichotomy of speech and language systems. ( 5664264 )
1968
50
Childhood echolalia. A group study of late abatement. ( 5582245 )
1967

Variations for Echolalia

Expression for Echolalia

Search GEO for disease gene expression data for Echolalia.

Pathways for Echolalia

GO Terms for Echolalia

Cellular components related to Echolalia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin complex GO:0008305 8.96 ENSG00000259753 ITGB3
2 growth cone GO:0030426 8.8 FMR1 MAPT PSEN1

Biological processes related to Echolalia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.5 FMR1 ITGB3 PSEN1
2 positive regulation of dendritic spine development GO:0060999 9.26 FMR1 PSEN1
3 angiogenesis involved in wound healing GO:0060055 9.16 ENSG00000259753 ITGB3
4 astrocyte activation GO:0048143 8.96 MAPT PSEN1
5 cell-substrate junction assembly GO:0007044 8.62 ENSG00000259753 ITGB3

Molecular functions related to Echolalia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 CBS FMR1 IKBKG ITGB3 MAPT
2 protein homodimerization activity GO:0042803 9.1 ADD2 CBS FMR1 IKBKG LGALS1 MAPT

Sources for Echolalia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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