MCID: ECL001
MIFTS: 53

Eclampsia

Categories: Cardiovascular diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Eclampsia

MalaCards integrated aliases for Eclampsia:

Name: Eclampsia 12 53 29 55 44 15 72 33
Eclampsia in Puerperium 12 72
Eclampsia, Postpartum 12
Postpartum Eclampsia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13593
MeSH 44 D004461
NCIt 50 C87167
SNOMED-CT 68 15938005
ICD10 33 O15 O15.2 O15.9
UMLS 72 C0013537 C0156678

Summaries for Eclampsia

Disease Ontology : 12 A pre-eclampsia characterized by the presence of seizures.

MalaCards based summary : Eclampsia, also known as eclampsia in puerperium, is related to severe pre-eclampsia and placental insufficiency, and has symptoms including seizures An important gene associated with Eclampsia is STOX1 (Storkhead Box 1), and among its related pathways/superpathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Warfarin Pathway, Pharmacodynamics. The drugs Magnesium oxide and Magnesium Sulfate have been mentioned in the context of this disorder. Affiliated tissues include placenta, endothelial and testes, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 75 Eclampsia is the onset of seizures (convulsions) in a woman with pre-eclampsia. Pre-eclampsia is a... more...

Related Diseases for Eclampsia

Diseases in the Eclampsia family:

Pre-Eclampsia Severe Pre-Eclampsia

Diseases related to Eclampsia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 499)
# Related Disease Score Top Affiliating Genes
1 severe pre-eclampsia 33.6 SERPINC1 PGF HLA-G ALB
2 placental insufficiency 31.1 PGF FLT1 F2
3 hellp syndrome 30.7 THBD SERPINC1 PGF MTHFR FLT1 F2
4 retinal vascular disease 30.2 PGF MTHFR FLT1 ALB
5 disseminated intravascular coagulation 30.1 THBD SERPINC1 F2
6 microvascular complications of diabetes 5 30.1 PGF FLT1 ALB
7 intracranial hypertension 29.7 SERPINC1 MTHFR F2
8 placenta disease 29.7 SERPINC1 PGF PAPPA OXT MTHFR
9 purpura 29.6 THBD SERPINC1 F2
10 thrombophlebitis 29.5 SERPINC1 MTHFR F2
11 retinal vein occlusion 29.5 SERPINC1 MTHFR F2
12 thrombophilia 29.5 THBD SERPINC1 MTHFR F2
13 antiphospholipid syndrome 29.5 THBD SERPINC1 MTHFR F2
14 antithrombin iii deficiency 29.4 SERPINC1 MTHFR F2
15 protein s deficiency 29.4 SERPINC1 MTHFR F2
16 bilirubin metabolic disorder 29.4 OXT F2 ALB
17 homocysteinemia 29.4 SERPINC1 MTHFR F2 ALB
18 sagittal sinus thrombosis 29.3 SERPINC1 F2
19 central retinal vein occlusion 29.2 SERPINC1 MTHFR F2
20 portal vein thrombosis 29.2 SERPINC1 MTHFR F2
21 placental abruption 29.1 THBD SERPINC1 PGF MTHFR FLT1 F2
22 thrombophilia due to thrombin defect 29.1 THBD SERPINC1 MTHFR F2
23 budd-chiari syndrome 29.1 SERPINC1 MTHFR F2
24 endocarditis 29.1 SERPINC1 F2 ALB
25 thrombophilia due to activated protein c resistance 29.1 THBD SERPINC1 MTHFR F2
26 arteries, anomalies of 29.0 SERPINC1 PGF FLT1 ALB
27 thrombosis 29.0 THBD SERPINC1 MTHFR F2
28 pre-eclampsia 29.0 THBD TAC3 STOX1 SERPINC1 PGF PAPPA
29 stroke, ischemic 28.9 THBD SERPINC1 MTHFR F2
30 protein c deficiency 28.7 THBD SERPINC1 MTHFR F2
31 pulmonary embolism 28.7 SERPINC1 MTHFR F2 ALB
32 vascular disease 28.7 THBD SERPINC1 MTHFR F2 ENG ALB
33 hepatic infarction 28.5 SERPINC1 OXT MTHFR F2
34 blood coagulation disease 28.5 THBD SERPINC1 MTHFR F2
35 peripheral vascular disease 28.3 THBD SERPINC1 F2 ALB
36 preeclampsia/eclampsia 4 12.7
37 preeclampsia/eclampsia 5 12.7
38 mild pre-eclampsia 12.6
39 preeclampsia/eclampsia 1 12.4
40 preeclampsia/eclampsia 2 12.4
41 preeclampsia/eclampsia 3 12.4
42 gestational diabetes 11.6
43 chorea gravidarum 11.2
44 encephalopathy 10.7
45 glomeruloid hemangioma 10.6 FLT1 ENG
46 yemenite deaf-blind hypopigmentation syndrome 10.6
47 acute kidney failure 10.6
48 hydrops, lactic acidosis, and sideroblastic anemia 10.6
49 twin-to-twin transfusion syndrome 10.6 PGF FLT1 ENG
50 thrombocytopenia 10.6

Graphical network of the top 20 diseases related to Eclampsia:



Diseases related to Eclampsia

Symptoms & Phenotypes for Eclampsia

UMLS symptoms related to Eclampsia:


seizures

MGI Mouse Phenotypes related to Eclampsia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 CORIN ENG F2 FLT1 NOSTRIN OXT
2 growth/size/body region MP:0005378 9.9 CORIN ENG F2 FLT1 INHBB MTHFR
3 homeostasis/metabolism MP:0005376 9.83 ALB CORIN ENG EPHX1 F2 FLT1
4 digestive/alimentary MP:0005381 9.8 ALB ENG F2 INHBB OXT TAC3
5 integument MP:0010771 9.23 CORIN ENG F2 INHBB MTHFR OXT

Drugs & Therapeutics for Eclampsia

Drugs for Eclampsia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 375)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Magnesium oxide Approved Phase 4 1309-48-4 14792
2
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Dinoprostone Approved Phase 4 363-24-6 5280360
5
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
6
leucovorin Approved Phase 4 58-05-9 143 6006
7
Remifentanil Approved Phase 4 132875-61-7 60815
8
Enoxaparin Approved Phase 4 9005-49-6 772
9
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
10
Dalteparin Approved Phase 4 9005-49-6
11
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
12
Scopolamine Approved, Investigational Phase 4 6533-68-2, 51-34-3 5184
13
Clonidine Approved Phase 4 4205-90-7 2803
14
Procaterol Approved, Investigational Phase 4 72332-33-3 688561
15
Captopril Approved Phase 4 62571-86-2 44093
16
Carbetocin Approved, Investigational Phase 4 37025-55-1 16681432 71715
17
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
18
Phenylephrine Approved Phase 4 59-42-7 6041
19
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
20
Azithromycin Approved Phase 4 83905-01-5 447043 55185
21
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
22
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
23
Alprostadil Approved, Investigational Phase 4 745-65-3 5280723 149351
24
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
25
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
26
Acetaminophen Approved Phase 4 103-90-2 1983
27
Ibuprofen Approved Phase 4 15687-27-1 3672
28
Desogestrel Approved Phase 4 54024-22-5 40973
29
Etonogestrel Approved, Investigational Phase 4 54048-10-1 6917715 40976
30
Metformin Approved Phase 4 657-24-9 4091 14219
31
Zinc Approved, Investigational Phase 4 7440-66-6 32051
32
Glyburide Approved Phase 4 10238-21-8 3488
33
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
34
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
35 Tocolytic Agents Phase 4
36 Anticonvulsants Phase 4
37 Anti-Arrhythmia Agents Phase 4
38 calcium channel blockers Phase 4
39 Antihypertensive Agents Phase 4
40 Antiemetics Phase 4
41 Autonomic Agents Phase 4
42 Adrenergic alpha-Agonists Phase 4
43 Adrenergic Agonists Phase 4
44 Adrenergic Agents Phase 4
45 Anesthetics, Local Phase 4
46 Sodium Channel Blockers Phase 4
47 Diuretics, Potassium Sparing Phase 4
48 Adrenergic alpha-2 Receptor Agonists Phase 4
49 calcium heparin Phase 4
50 Sympatholytics Phase 4

Interventional clinical trials:

(show top 50) (show all 609)
# Name Status NCT ID Phase Drugs
1 Low Dose Calcium Supplementation to Prevent Preeclampsia: a Cluster Randomized Study Unknown status NCT02338687 Phase 4
2 Remifentanil for c-Section With General Anesthesia in Severe Preeclamptic Patients Unknown status NCT00567957 Phase 4 Remifentanil;Saline
3 Effectiveness Of Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia: Randomized Placebo-Controlled Clinical Trial Unknown status NCT01361425 Phase 4 methildopa;placebo
4 Cardiovascular Performance and Autonomic Reactivity in Formerly Preeclamptic Women With a Contracted Plasma Volume (CAPACITY Trial) Unknown status NCT00117546 Phase 4 alpha methyldopa
5 Magnesium Deficiency in Cirrhotic Patients Unknown status NCT01894867 Phase 4
6 Effect of Administering Intravenous Magnesium Sulfate Heptahydrate (MgSO4•7H2O) on Fetal Cardiotocography and Neonatal Outcome in Preeclamptic Patients in 3rd Trimester of Pregnancy Unknown status NCT03237000 Phase 4 MgSO4
7 Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers Completed NCT01729468 Phase 4 Aspirin;Placebo
8 An Open-label Randomized-Controlled Trial of Early Screening Test for Pre-eclampsia and Growth Restriction Completed NCT03674606 Phase 4 Low dose aspirin
9 Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Blockade in Gynaecology Patients Completed NCT01972659 Phase 4 placebo;Magnesium Sulphate;sugammadex
10 Evaluation of Dose-response Effect of Acetylsalicylic Acid on Placental Development, Preterm Birth, Fetal Growth and Hypertension in Pregnancy in Women With Previous History of Preeclampsia Completed NCT01352234 Phase 4 Acetylsalicylic Acid 160 mg;Acetylsalicylic Acid 80 mg
11 Postpartum Prophylaxis With Short Course Magnesium Sulfate in Severe Preeclampsia: a Randomized Clinical Trial Completed NCT01408979 Phase 4 Magnesium sulfate 12 hours;Magnesium sulfate 24 hours
12 A Randomized Open-label Study to Compare the Clinical Outcomes and Magnesium Serum Concentrations Obtained in the Treatment of Severe Preeclampsia With a Repeat Bolus Intravenous Magnesium Sulfate Regimen Administered With the Springfusor Infusion Pump to a Continuous Intravenous Magnesium Sulfate Regimen Completed NCT02091401 Phase 4 Magnesium Sulfate
13 A Randomized-controlled Trial to Assess the Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy Completed NCT02891174 Phase 4 Ibuprofen;Acetaminophen
14 Effectiveness of Postpartum Furosemide on Recovery Blood Pressure in Puerperal Women With Severe Preeclampsia: a Randomized Clinical Trial Completed NCT02163655 Phase 4 FUROSEMIDE;Placebo
15 Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy Completed NCT01912677 Phase 4 Nifedipine;Labetalol;Methyldopa
16 Adding Magnesium Sulphate to Epidural Levobupivacaine in Elective Caesarian Section for Patients With Preeclampsia Completed NCT02699827 Phase 4 Levobupivacaine hydrochloride;Magnesium sulphate;Saline 0.9%
17 Treatment Approaches to Preeclampsia Completed NCT01030627 Phase 4
18 Efficacy and Safety of Hyoscine N Butyl Bromide on the Augmentation of Labor: a Double-Blind, Placebo - Controlled Trial Completed NCT02098889 Phase 4 hyoscine-N-butyl bromide(HBB);Saline
19 Antepartum Study on Use of Interpersonal Psychotherapy at 3 New York City Sites Completed NCT00251043 Phase 4
20 A Prospective Multi-centre Randomised Comparison on Induction of Labour With Double-balloon Installation Device Versus Prostaglandin E2 Minprostin Completed NCT01255839 Phase 4 Minprostin
21 Ethnic Differences in Anti-Hypertensive Medication Response Among Pregnant and Postpartum Patients Completed NCT03506724 Phase 4 Nifedipine;Labetalol
22 Low Molecular Weight Heparin for Treatment of Recurrent Miscarriage With Negative Antiphospholipid Antibodies: a Randomized Controlled Trial Completed NCT01608347 Phase 4 LMWH+Folic acid;Folic Acid
23 Albuterol Dose-Response on Pulmonary Function Testing in Preterm Infants at Risk of Bronchopulmonary Dysplasia Completed NCT02447250 Phase 4 Varied albuterol dose response
24 Randomized Clinical Trial for Effectiveness of Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure Completed NCT01761916 Phase 4 CLONIDINE;CAPTOPRIL
25 Effect of Intravenous Infusion of Lidocaine, Magnesium Sulphate and Remifentanil Perioperatively in Patients Undergoing Mastectomy: a Prospective, Randomized and Double-blind Study Completed NCT02309879 Phase 4 Remifentanil infusion;Lidocaine infusion;Magnesium sulphate infusion;Magnesium sulphate and Lidocaine infusion
26 Effect of Myofascial Release on Electrophysiological and Clinical Measures of Pregnant Women With Carpal Tunnel Syndrome Completed NCT03802448 Phase 4
27 Impact of Vasopressor Administration on Maternal and Neonatal Outcomes in Women With Pre-eclampsia Recruiting NCT02025426 Phase 4 Phenylephrine;Ephedrine
28 Efficacy and Safety of One Gram Versus Two Grams Intravenous Maintenance Dose of Magnesium Sulfate in Women With Severe Pre-eclampsia: a Randomized Clinical Trial. Recruiting NCT03164304 Phase 4 Magnesium Sulfate
29 Oral Nifedipine Versus Labetalol in Treatment of Postpartum Hypertension Recruiting NCT03449277 Phase 4 Oral Tablet
30 Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies--A Multicenter, Prospective, Open, Randomized, Controlled Clinical Trial Recruiting NCT04051567 Phase 4 Aspirin 100mg
31 Personalized Hemodynamically Guided Antihypertensive Treatment in Pregnant Women With Mild to Moderate Hypertension: a Randomized Controlled Trial Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
32 Impact of Antichlamydial Treatment on the Rate of Preeclampsia Among Egyptian Primigravidae: a Randomized Controlled Trial Recruiting NCT03233880 Phase 4 Azithromycin 1gm
33 The Effect of 81mg vs 162mg ASA for Preeclampsia Prevention in Obese Women at High Risk for Developing Preeclampsia Recruiting NCT03735433 Phase 4 162mg aspirin dose
34 Metformin for Preeclampsia Prevention in Pregnant Women With Type 1 Diabetes Mellitus Recruiting NCT03570632 Phase 4 Metformin
35 A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Recruiting NCT02920593 Phase 4 Vitamin D3
36 Acute Control of Chronic Hypertension in Preeclampsia Recruiting NCT03877692 Phase 4 Experimental dosing of labetalol
37 Acute Labetalol Use in Preeclampsia Randomized Trial Recruiting NCT03872336 Phase 4 Experimental labetalol dose
38 Carbetocin Versus Misoprostol for Prevention of Postpartum Hemorrhage in Pregnant Women at High Risk Following C.S. Recruiting NCT02277067 Phase 4 Carbetocin;Misoprostol
39 Interaction Between Intravenous Magnesium Sulphate and Neostigmine or Sugammadex for the Reversal of a Rocuronium-induced Neuromuscular Block - A Randomized, Double Blinded, Electrophysiological Study Recruiting NCT03497923 Phase 4 Magnesium Sulfate
40 Effect of Non-steroidal Anti-inflammatory Use on Blood Pressure in Women With Hypertensive Disorders of Pregnancy: A Randomized Open Label Trial Recruiting NCT03824119 Phase 4 Ibuprofen 600 mg
41 The Effect of Antibiotics on Latency in Previable Prelabor Rupture of Membranes Between 18 0/7 and 22 6/7 Weeks Gestational Age Recruiting NCT04047849 Phase 4 Antibiotics, oral Azithromycin and oral Amoxicillin
42 Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features Active, not recruiting NCT02911701 Phase 4 Acetaminophen;Ibuprofen
43 Use of Etonogestrel-releasing Contraceptive Implant in Women With Sickle Cell Disease Active, not recruiting NCT02594462 Phase 4 etonogestrel-releasing implant contraceptive
44 Continuation Versus Discontinuation of Magnesium Sulfate After Delivery in Women With Severe Preeclampsia. A Randomized Controlled Trial Not yet recruiting NCT03318211 Phase 4 Magnesium Sulfate
45 Threshold for Initiation of Medical Treatment for Women With Gestational Diabetes: A Single Site Randomized Trial Not yet recruiting NCT03527537 Phase 4 Insulin;Glyburide;Metformin
46 Effectiveness and Safety of 1g/Hour vs. 2g/Hour of Magnesium Sulfate Maintenance Dose for Eclampsia Prevention: Randomized Clinical Trial Terminated NCT02396030 Phase 4 Magnesium sulfate 50% - 1g/h;Magnesium sulfate 50% - 2g/h
47 Clinical Effect of Atenativ Treatment on Uterine Blood Flow and the Amount of Atenativ Needed to Maintain a Normal Antithrombin Lvels During Two Weeks in Early and Severe Preeclampsia Withdrawn NCT02278575 Phase 4 Atenativ
48 Pilot Double-Blind Placebo Controlled Trial of Levothyroxine in Pregnant Systemic Lupus Erythematosus (SLE) Patients With Autoimmune Thyroid Disease Withdrawn NCT01276782 Phase 4 Levothyroxine
49 Carbetocin Versus Oxytocin for Prevention of Postpartum Hemorrhage in Patients With Severe Preeclampsia: a Double Blind Randomized Controlled Trial Unknown status NCT01382732 Phase 3 Carbetocin;Oxytocin
50 Use of Sildenafil Citrate in Management of Mild Pre-eclampsia: A Randomized Controlled Trial Unknown status NCT03262961 Phase 2, Phase 3 Sildenafil 20 MG;Placebo Oral Tablet

Search NIH Clinical Center for Eclampsia

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Magnesium Sulfate
Nitroglycerin

Cochrane evidence based reviews: eclampsia

Genetic Tests for Eclampsia

Genetic tests related to Eclampsia:

# Genetic test Affiliating Genes
1 Eclampsia 29

Anatomical Context for Eclampsia

MalaCards organs/tissues related to Eclampsia:

41
Placenta, Endothelial, Testes, Liver, Kidney, Heart, Brain

Publications for Eclampsia

Articles related to Eclampsia:

(show top 50) (show all 14549)
# Title Authors PMID Year
1
Correlation between maternal plasma thrombomodulin and infant birth weight in hypertensive disorders of pregnancy. 9 38
19022800 2009
2
Evaluation of natural coagulation inhibitor levels in various hypertensive states of pregnancy. 9 38
15893867 2005
3
Absence of Factor V Leiden, thrombomodulin and prothrombin gene variants in Black South African women with pre-eclampsia and eclampsia. 9 38
12628278 2003
4
[Folic acid levels, homocysteine and polymorphism of methylenetetrahydrofolate reductase enzyme (MTHFR) in patients with pre-eclampsia and eclampsia]. 9 38
11268732 2001
5
Methylenetetrahydrofolate reductase polymorphisms are not a risk factor for pre-eclampsia/eclampsia in Australian women. 9 38
10965192 2000
6
Methylenetetrahydrofolate reductase 677 C --> T polymorphism, plasma folate, vitamin B(12) concentrations, and risk of preeclampsia among black African women from Zimbabwe. 9 38
10655155 2000
7
[Antithrombin-III in preeclampsia-eclampsia. Pilot study]. 9 38
9745197 1998
8
Thrombomodulin levels during normal pregnancy, at delivery and in the postpartum: comparison with tissue-type plasminogen activator and plasminogen activator inhibitor-1. 9 38
9531039 1998
9
Thrombomodulin, plasminogen activator inhibitor type 1 (PAI-1) and fibronectin as biomarkers of endothelial damage in preeclampsia and eclampsia. 9 38
8960994 1996
10
HLA-G deletion polymorphism and pre-eclampsia/eclampsia. 9 38
7547760 1995
11
Pregnancy induced hypertension and antithrombin-III. 9 38
8819656 1995
12
[Antithrombin ii in eclampsia: estimation of predictive value]. 9 38
1345066 1992
13
Maternal sickle cell disease and twin pregnancy: a case series and review of the literature. 38
30345909 2019
14
Tetramethylpyrazine reduces the consequences of nitric oxide inhibition in pregnant rats. 38
30937928 2019
15
Evaluation of elabela, apelin and nitric oxide findings in maternal blood of normal pregnant women, pregnant women with pre-eclampsia, severe pre-eclampsia and umbilical arteries and venules of newborns. 38
31064239 2019
16
Acute kidney injury in preterm infants with necrotizing enterocolitis. 38
29631454 2019
17
Incidence and natural history of preeclampsia/eclampsia at the university maternity of Antananarivo, Madagascar: high prevalence of the early-onset condition. 38
29621911 2019
18
Analysis of preventability of hypertensive disorder in pregnancy-related maternal death using the nationwide registration system of maternal deaths in Japan. 38
29699420 2019
19
Posterior reversible encephalopathy syndrome: A review with emphasis on neuroimaging characteristics. 38
31349066 2019
20
EEG Findings in Posterior Reversible Encephalopathy Syndrome. 38
31215229 2019
21
Erratum to "The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention" [Int J Gynecol Obstet 145 Suppl. 1 (2019) 1-33]. 38
31378938 2019
22
Office blood pressure values and the necessity of out-of-office measurements in high-risk pregnancies. 38
31157745 2019
23
Severe maternal morbidity during delivery hospitalisation in a large international administrative database, 2008-2013: a retrospective cohort. 38
31100201 2019
24
Volume and vascularity: Using ultrasound to unlock the secrets of the first trimester placenta. 38
31279487 2019
25
Stillbirth in Women Living With HIV Delivering in the United Kingdom and Ireland: 2007-2015. 38
31149953 2019
26
Maternal and infant pregnancy outcomes in women with psoriatic arthritis: a Swedish nationwide cohort study. 38
31188526 2019
27
Identification of a distal allosteric ligand binding pocket in HtrA3. 38
31280864 2019
28
Type I interferon gene expression in antiphospholipid syndrome: Pathogenetic, clinical and therapeutic implications. 38
31378637 2019
29
Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open-label, randomised controlled trial. 38
31378394 2019
30
Inflammation - the role of ATP in pre-eclampsia. 38
31424615 2019
31
lncRNA GHET1 has effects in development of pre-eclampsia. 38
30861585 2019
32
Prenatal screening for pre-eclampsia: Frequently asked questions. 38
31119729 2019
33
Prepregnancy calcium supplementation and pre-eclampsia - Author's reply. 38
31424000 2019
34
Time to speed up the diagnosis of pre-eclampsia. 38
31345955 2019
35
Does pre-eclampsia without proteinuria lead to different pregnancy outcomes than pre-eclampsia with proteinuria? 38
31257699 2019
36
Prepregnancy calcium supplementation and pre-eclampsia. 38
31423998 2019
37
Prepregnancy calcium supplementation and pre-eclampsia. 38
31423999 2019
38
"The Flea Catcher" portrait: does it image pre-eclampsia or hypothyroidism? 38
31388838 2019
39
[Analysis of clinical early warning informations of severe preeclampsia before onset]. 38
31434428 2019
40
The clinical enigma of the "Flea catcher" by Georges de La Tour: a pregnant sinner with pre-eclampsia or a hypothyroid girl? 38
30730039 2019
41
Patient costs and outcomes before and after the institution of a pre-eclampsia quality improvement initiative in a southwestern tertiary facility. 38
31008661 2019
42
Upregulated long noncoding RNA Linc00261 in pre-eclampsia and its effect on trophoblast invasion and migration via regulating miR-558/TIMP4 signaling pathway. 38
30891826 2019
43
Authors' reply re: Evaluation of a simple risk score to predict preterm pre-eclampsia using maternal characteristics: a prospective cohort study. 38
31410976 2019
44
Methylenetetrahydrofolate Reductase Enzyme Level and Antioxidant Activity in Women with Gestational Hypertension and Pre-eclampsia in Lagos, Nigeria. 38
31391737 2019
45
Optical Coherence Tomography Findings in Pre-Eclampsia: A Preliminary Receiver Operating Characteristic Analysis on Choroidal Thickness for Disease Severity. 38
30983421 2019
46
Point of care ultrasound: does the presence of ascites in severe pre-eclampsia correlate with poor maternal and neonatal outcome? 38
31173433 2019
47
Metabolomics revealed decreased level of omega-3 PUFA-derived protective eicosanoids in pregnant women with pre-eclampsia. 38
30983029 2019
48
Osteoprotegerin and RANKL serum concentrations in neonates of mothers with early-onset pre-eclampsia: comparison with neonates of normotensive mothers. 38
31176082 2019
49
Gestational hypertension and pre-eclampsia and risk of spontaneous premature rupture of membranes: A population-based cohort study. 38
31420867 2019
50
Re: Evaluation of a simple risk score to predict preterm pre-eclampsia using maternal characteristics: a prospective cohort study. 38
31410975 2019

Variations for Eclampsia

Expression for Eclampsia

Search GEO for disease gene expression data for Eclampsia.

Pathways for Eclampsia

Pathways related to Eclampsia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.28 PAPPA F2
2 9.8 F2 EPHX1

GO Terms for Eclampsia

Cellular components related to Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TAC3 SERPINC1 PGF PAPPA OXT INHBB
2 endoplasmic reticulum lumen GO:0005788 9.46 SERPINC1 F2 ERAP2 ALB
3 extracellular space GO:0005615 9.36 THBD TAC3 SERPINC1 PGF PAPPA OXT

Biological processes related to Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.46 SERPINC1 PAPPA F2 ALB
2 vascular endothelial growth factor signaling pathway GO:0038084 9.4 PGF FLT1
3 regulation of blood coagulation GO:0030193 9.37 SERPINC1 F2
4 negative regulation of fibrinolysis GO:0051918 9.32 THBD F2
5 negative regulation of platelet activation GO:0010544 9.26 THBD F2
6 hemostasis GO:0007599 9.13 THBD SERPINC1 F2
7 female pregnancy GO:0007565 9.1 THBD TAC3 PGF PAPPA OXT CORIN

Sources for Eclampsia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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