MCID: ECL001
MIFTS: 50

Eclampsia

Categories: Cardiovascular diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Eclampsia

MalaCards integrated aliases for Eclampsia:

Name: Eclampsia 12 52 29 54 43 15 71 32
Eclampsia in Puerperium 12 71
Eclampsia, Postpartum 12
Postpartum Eclampsia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13593
MeSH 43 D004461
NCIt 49 C87167
SNOMED-CT 67 15938005
ICD10 32 O15 O15.2
UMLS 71 C0013537 C0156678

Summaries for Eclampsia

Disease Ontology : 12 A pre-eclampsia characterized by the presence of seizures.

MalaCards based summary : Eclampsia, also known as eclampsia in puerperium, is related to preeclampsia/eclampsia 1 and severe pre-eclampsia, and has symptoms including seizures An important gene associated with Eclampsia is STOX1 (Storkhead Box 1), and among its related pathways/superpathways are Signaling events mediated by VEGFR1 and VEGFR2 and Glypican 1 network. The drugs Magnesium oxide and Magnesium Sulfate have been mentioned in the context of this disorder. Affiliated tissues include placenta, endothelial and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Eclampsia is the onset of seizures (convulsions) in a woman with pre-eclampsia. Pre-eclampsia is a... more...

Related Diseases for Eclampsia

Diseases in the Eclampsia family:

Pre-Eclampsia Severe Pre-Eclampsia

Diseases related to Eclampsia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 512)
# Related Disease Score Top Affiliating Genes
1 preeclampsia/eclampsia 1 34.0 SERPINC1 PEE1
2 severe pre-eclampsia 33.6 VEGFA SERPINC1 PGF PAPPA LGALS13 HLA-G
3 mild pre-eclampsia 33.2 VEGFA PGF PAPPA OXT LGALS13 FLT1
4 hellp syndrome 31.5 VEGFA THBD SERPINC1 PGF MTHFR LGALS13
5 hypertensive encephalopathy 31.3 VEGFA FLT1
6 peripartum cardiomyopathy 30.9 VEGFA PGF FLT1
7 pre-eclampsia 30.6 VEGFA THBD TAC3 STOX1 SERPINC1 PGF
8 chorioamnionitis 30.5 VEGFA OXT FLT1
9 placenta praevia 30.4 PGF PAPPA OXT
10 placental insufficiency 30.4 VEGFA SERPINC1 PGF PAPPA FLT1
11 retinal vascular disease 30.4 VEGFA PGF MTHFR FLT1
12 antiphospholipid syndrome 30.3 THBD SERPINC1 PGF MTHFR
13 oligohydramnios 30.2 PGF PAPPA OXT
14 pregnancy loss, recurrent 1 30.1 MTHFR HLA-G
15 vascular disease 30.1 VEGFA THBD SERPINC1 MTHFR ENG
16 retinal vein occlusion 30.1 VEGFA SERPINC1 MTHFR
17 thrombophilia due to thrombin defect 30.0 THBD SERPINC1 MTHFR
18 thrombophilia due to activated protein c resistance 30.0 THBD SERPINC1 MTHFR
19 ectopic pregnancy 30.0 VEGFA PGF PAPPA FLT1
20 homocysteinemia 30.0 THBD SERPINC1 MTHFR
21 exudative vitreoretinopathy 1 29.9 VEGFA PGF FLT1
22 placental abruption 29.9 THBD SERPINC1 PGF PAPPA MTHFR HLA-G
23 microvascular complications of diabetes 5 29.8 VEGFA PGF FLT1
24 protein s deficiency 29.6 THBD SERPINC1 MTHFR
25 protein c deficiency 29.6 THBD SERPINC1 MTHFR
26 placenta accreta 29.6 PGF PAPPA OXT FLT1
27 stroke, ischemic 29.6 VEGFA THBD SERPINC1 MTHFR ENG
28 placenta disease 29.5 VEGFA SERPINC1 PGF PAPPA OXT MTHFR
29 central retinal vein occlusion 29.5 VEGFA SERPINC1 PGF MTHFR
30 pulmonary embolism 29.3 THBD SERPINC1 MTHFR
31 blood coagulation disease 29.2 VEGFA THBD SERPINC1 MTHFR
32 peripheral vascular disease 29.1 VEGFA THBD SERPINC1 MTHFR ENG
33 hypertension, essential 28.6 VEGFA THBD SERPINC1 PGF PAPPA OXT
34 myocardial infarction 28.4 VEGFA THBD SERPINC1 PGF PAPPA MTHFR
35 preeclampsia/eclampsia 4 12.7
36 preeclampsia/eclampsia 5 12.7
37 preeclampsia/eclampsia 2 12.4
38 preeclampsia/eclampsia 3 12.4
39 gestational diabetes 11.6
40 chorea gravidarum 11.2
41 encephalopathy 10.7
42 yemenite deaf-blind hypopigmentation syndrome 10.6
43 disseminated intravascular coagulation 10.6
44 acute kidney failure 10.6
45 thrombocytopenia 10.5
46 microcystic meningioma 10.5 VEGFA FLT1
47 hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy 10.5
48 pulmonary edema 10.5
49 hemifacial spasm 10.5 VEGFA MTHFR
50 cortical blindness 10.5

Graphical network of the top 20 diseases related to Eclampsia:



Diseases related to Eclampsia

Symptoms & Phenotypes for Eclampsia

UMLS symptoms related to Eclampsia:


seizures

MGI Mouse Phenotypes related to Eclampsia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 CORIN ENG FLT1 NOSTRIN OXT PAPPA
2 homeostasis/metabolism MP:0005376 9.47 CORIN ENG EPHX1 FLT1 HLA-G INHBB

Drugs & Therapeutics for Eclampsia

Drugs for Eclampsia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 355)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Magnesium oxide Approved Phase 4 1309-48-4 14792
2
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
3
Dinoprostone Approved Phase 4 363-24-6 5280360
4
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
5
leucovorin Approved Phase 4 58-05-9 6006 143
6
Remifentanil Approved Phase 4 132875-61-7 60815
7
Enoxaparin Approved Phase 4 9005-49-6 772
8
Tinzaparin Approved Phase 4 9041-08-1, 9005-49-6 25244225
9
Dalteparin Approved Phase 4 9005-49-6
10
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
11
Scopolamine Approved, Investigational Phase 4 6533-68-2, 51-34-3 5184
12
Clonidine Approved Phase 4 4205-90-7 2803
13
Procaterol Approved, Investigational Phase 4 72332-33-3 688561
14
Captopril Approved Phase 4 62571-86-2 44093
15
Carbetocin Approved, Investigational Phase 4 37025-55-1 71715 16681432
16
Misoprostol Approved Phase 4 59122-46-2 5282381
17
Acetaminophen Approved Phase 4 103-90-2 1983
18
Ibuprofen Approved Phase 4 15687-27-1 3672
19
Enalapril Approved, Vet_approved Phase 4 75847-73-3 40466924 5362032
20
Enalaprilat Approved Phase 4 76420-72-9 6917719
21
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
22
Azithromycin Approved Phase 4 83905-01-5 447043 55185
23
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
24
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
25
Alprostadil Approved, Investigational Phase 4 745-65-3 149351 5280723
26
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
27
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
28
Desogestrel Approved Phase 4 54024-22-5 40973
29
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
30
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
31
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
32
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
33
Metformin Approved Phase 4 657-24-9 14219 4091
34
Glyburide Approved Phase 4 10238-21-8 3488
35
Phenylephrine Approved Phase 4 59-42-7 6041
36
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
37
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
38 Tocolytic Agents Phase 4
39 calcium channel blockers Phase 4
40 Antihypertensive Agents Phase 4
41 Antiemetics Phase 4
42 Adrenergic alpha-Agonists Phase 4
43 Adrenergic Agonists Phase 4
44 Anesthetics, Local Phase 4
45 Antibodies, Antiphospholipid Phase 4
46 calcium heparin Phase 4
47 Sympatholytics Phase 4
48 Vitamin B Complex Phase 4
49 Folate Phase 4
50 Vitamin B9 Phase 4

Interventional clinical trials:

(show top 50) (show all 681)
# Name Status NCT ID Phase Drugs
1 Low Dose Calcium Supplementation to Prevent Preeclampsia: a Cluster Randomized Study Unknown status NCT02338687 Phase 4
2 Oral Nifedipine Versus Labetalol in Treatment of Postpartum Hypertension Unknown status NCT03449277 Phase 4 Oral Tablet
3 Remifentanil for c-Section With General Anesthesia in Severe Preeclamptic Patients Unknown status NCT00567957 Phase 4 Remifentanil;Saline
4 Effectiveness Of Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia: Randomized Placebo-Controlled Clinical Trial Unknown status NCT01361425 Phase 4 methildopa;placebo
5 Cardiovascular Performance and Autonomic Reactivity in Formerly Preeclamptic Women With a Contracted Plasma Volume (CAPACITY Trial) Unknown status NCT00117546 Phase 4 alpha methyldopa
6 Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features Unknown status NCT02911701 Phase 4 Acetaminophen;Ibuprofen
7 Impact of Antichlamydial Treatment on the Rate of Preeclampsia Among Egyptian Primigravidae: a Randomized Controlled Trial Unknown status NCT03233880 Phase 4 Azithromycin 1gm
8 Continuation Versus Discontinuation of Magnesium Sulfate After Delivery in Women With Severe Preeclampsia. A Randomized Controlled Trial Unknown status NCT03318211 Phase 4 Magnesium Sulfate
9 A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Unknown status NCT02920593 Phase 4 Vitamin D3
10 Magnesium Deficiency in Cirrhotic Patients Unknown status NCT01894867 Phase 4
11 Effect of Administering Intravenous Magnesium Sulfate Heptahydrate (MgSO4•7H2O) on Fetal Cardiotocography and Neonatal Outcome in Preeclamptic Patients in 3rd Trimester of Pregnancy Unknown status NCT03237000 Phase 4 MgSO4
12 Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers Completed NCT01729468 Phase 4 Aspirin;Placebo
13 Efficacy and Safety of One Gram Versus Two Grams Intravenous Maintenance Dose of Magnesium Sulfate in Women With Severe Pre-eclampsia: a Randomized Clinical Trial. Completed NCT03164304 Phase 4 Magnesium Sulfate
14 An Open-label Randomized-Controlled Trial of Early Screening Test for Pre-eclampsia and Growth Restriction Completed NCT03674606 Phase 4 Low dose aspirin
15 Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Blockade in Gynaecology Patients Completed NCT01972659 Phase 4 placebo;Magnesium Sulphate;sugammadex
16 Evaluation of Dose-response Effect of Acetylsalicylic Acid on Placental Development, Preterm Birth, Fetal Growth and Hypertension in Pregnancy in Women With Previous History of Preeclampsia Completed NCT01352234 Phase 4 Acetylsalicylic Acid 160 mg;Acetylsalicylic Acid 80 mg
17 Postpartum Prophylaxis With Short Course Magnesium Sulfate in Severe Preeclampsia: a Randomized Clinical Trial Completed NCT01408979 Phase 4 Magnesium sulfate 12 hours;Magnesium sulfate 24 hours
18 A Randomized Open-label Study to Compare the Clinical Outcomes and Magnesium Serum Concentrations Obtained in the Treatment of Severe Preeclampsia With a Repeat Bolus Intravenous Magnesium Sulfate Regimen Administered With the Springfusor Infusion Pump to a Continuous Intravenous Magnesium Sulfate Regimen Completed NCT02091401 Phase 4 Magnesium Sulfate
19 A Randomized-controlled Trial to Assess the Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy Completed NCT02891174 Phase 4 Ibuprofen;Acetaminophen
20 Effectiveness of Postpartum Furosemide on Recovery Blood Pressure in Puerperal Women With Severe Preeclampsia: a Randomized Clinical Trial Completed NCT02163655 Phase 4 FUROSEMIDE;Placebo
21 Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy Completed NCT01912677 Phase 4 Nifedipine;Labetalol;Methyldopa
22 Adding Magnesium Sulphate to Epidural Levobupivacaine in Elective Caesarian Section for Patients With Preeclampsia Completed NCT02699827 Phase 4 Levobupivacaine hydrochloride;Magnesium sulphate;Saline 0.9%
23 Treatment Approaches to Preeclampsia Completed NCT01030627 Phase 4
24 Randomized Trial of Magnesium Sulfate in Obese Preeclamptic Women Completed NCT02835339 Phase 4 Magnesium sulfate 4g loading dose, 1g/hr infusion;Magnesium sulfate 6g loading dose, 2g/hr infusion
25 Ethnic Differences in Anti-Hypertensive Medication Response Among Pregnant and Postpartum Patients Completed NCT03506724 Phase 4 Nifedipine;Labetalol
26 A Prospective Multi-centre Randomised Comparison on Induction of Labour With Double-balloon Installation Device Versus Prostaglandin E2 Minprostin Completed NCT01255839 Phase 4 Minprostin
27 Antepartum Study on Use of Interpersonal Psychotherapy at 3 New York City Sites Completed NCT00251043 Phase 4
28 Low Molecular Weight Heparin for Treatment of Recurrent Miscarriage With Negative Antiphospholipid Antibodies: a Randomized Controlled Trial Completed NCT01608347 Phase 4 LMWH+Folic acid;Folic Acid
29 Efficacy and Safety of Hyoscine N Butyl Bromide on the Augmentation of Labor: a Double-Blind, Placebo - Controlled Trial Completed NCT02098889 Phase 4 hyoscine-N-butyl bromide(HBB);Saline
30 Albuterol Dose-Response on Pulmonary Function Testing in Preterm Infants at Risk of Bronchopulmonary Dysplasia Completed NCT02447250 Phase 4 Varied albuterol dose response
31 Randomized Clinical Trial for Effectiveness of Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure Completed NCT01761916 Phase 4 CLONIDINE;CAPTOPRIL
32 Effect of Intravenous Infusion of Lidocaine, Magnesium Sulphate and Remifentanil Perioperatively in Patients Undergoing Mastectomy: a Prospective, Randomized and Double-blind Study Completed NCT02309879 Phase 4 Remifentanil infusion;Lidocaine infusion;Magnesium sulphate infusion;Magnesium sulphate and Lidocaine infusion
33 Effect of Myofascial Release on Electrophysiological and Clinical Measures of Pregnant Women With Carpal Tunnel Syndrome Completed NCT03802448 Phase 4
34 Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies--A Multicenter, Prospective, Open, Randomized, Controlled Clinical Trial Recruiting NCT04051567 Phase 4 Aspirin 100mg
35 Personalized Hemodynamically Guided Antihypertensive Treatment in Pregnant Women With Mild to Moderate Hypertension: a Randomized Controlled Trial Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
36 Efficacy of 17-Hydroxyprogesterone Caproate in Expectantly Managed Early-onset Preeclampsia: A Randomized Controlled Study Recruiting NCT04077853 Phase 4 17 Hydroxyprogesterone Capronate
37 Nifedipine XL Versus Placebo for the Treatment of Preeclampsia With Severe Features During Induction of Labor Recruiting NCT04392375 Phase 4 Nifedipine 30 MG;Placebos
38 Metformin for Preeclampsia Prevention in Pregnant Women With Type 1 Diabetes Mellitus Recruiting NCT03570632 Phase 4 Metformin
39 The Effect of 81mg vs 162mg ASA for Preeclampsia Prevention in Obese Women at High Risk for Developing Preeclampsia Recruiting NCT03735433 Phase 4 162mg aspirin dose
40 A Randomized Controlled Trial Comparing Nifedipine and Enalapril in Medical Resources Used in the Postpartum Period Recruiting NCT04236258 Phase 4 NIFEdipine ER;Enalapril
41 Acute Control of Chronic Hypertension in Preeclampsia Recruiting NCT03877692 Phase 4 Experimental dosing of labetalol
42 Acute Labetalol Use in Preeclampsia Randomized Trial Recruiting NCT03872336 Phase 4 Experimental labetalol dose
43 Carbetocin Versus Misoprostol for Prevention of Postpartum Hemorrhage in Pregnant Women at High Risk Following C.S. Recruiting NCT02277067 Phase 4 Carbetocin;Misoprostol
44 Magnesium Infusion for Pain Management in Critically Ill Trauma Patients Recruiting NCT04166877 Phase 4 Magnesium Sulfate in Parenteral Dosage Form;Normal saline placebo
45 Interaction Between Intravenous Magnesium Sulphate and Neostigmine or Sugammadex for the Reversal of a Rocuronium-induced Neuromuscular Block - A Randomized, Double Blinded, Electrophysiological Study Recruiting NCT03497923 Phase 4 Magnesium Sulfate
46 Effect of Non-steroidal Anti-inflammatory Use on Blood Pressure in Women With Hypertensive Disorders of Pregnancy: A Randomized Open Label Trial Recruiting NCT03824119 Phase 4 Ibuprofen 600 mg
47 The Effect of Antibiotics on Latency in Previable Prelabor Rupture of Membranes Between 18 0/7 and 22 6/7 Weeks Gestational Age Recruiting NCT04047849 Phase 4 Antibiotics, oral Azithromycin and oral Amoxicillin
48 Use of Etonogestrel-releasing Contraceptive Implant in Women With Sickle Cell Disease Active, not recruiting NCT02594462 Phase 4 etonogestrel-releasing implant contraceptive
49 Postpartum Management of Gestational Hypertensive Disorders Using Furosemide: A Randomized Controlled Trial Enrolling by invitation NCT04343235 Phase 4 furosemide;labetalol
50 Lignocaine Nebulization for Attenuation of Intubation Stress Response in Patients With Severe Pre-eclampsia: a Prospective Double-blinded Placebo-controlled Trial Not yet recruiting NCT04441073 Phase 4 Lignocaine;Placebo

Search NIH Clinical Center for Eclampsia

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Magnesium Sulfate
Nitroglycerin

Cochrane evidence based reviews: eclampsia

Genetic Tests for Eclampsia

Genetic tests related to Eclampsia:

# Genetic test Affiliating Genes
1 Eclampsia 29

Anatomical Context for Eclampsia

MalaCards organs/tissues related to Eclampsia:

40
Placenta, Endothelial, Testes, Liver, Kidney, Heart, Brain

Publications for Eclampsia

Articles related to Eclampsia:

(show top 50) (show all 15155)
# Title Authors PMID Year
1
Correlation between maternal plasma thrombomodulin and infant birth weight in hypertensive disorders of pregnancy. 61 54
19022800 2009
2
Evaluation of natural coagulation inhibitor levels in various hypertensive states of pregnancy. 61 54
15893867 2005
3
Absence of Factor V Leiden, thrombomodulin and prothrombin gene variants in Black South African women with pre-eclampsia and eclampsia. 61 54
12628278 2003
4
[Folic acid levels, homocysteine and polymorphism of methylenetetrahydrofolate reductase enzyme (MTHFR) in patients with pre-eclampsia and eclampsia]. 54 61
11268732 2001
5
Methylenetetrahydrofolate reductase 677 C --> T polymorphism, plasma folate, vitamin B(12) concentrations, and risk of preeclampsia among black African women from Zimbabwe. 54 61
10655155 2000
6
Methylenetetrahydrofolate reductase polymorphisms are not a risk factor for pre-eclampsia/eclampsia in Australian women. 61 54
10965192 2000
7
[Antithrombin-III in preeclampsia-eclampsia. Pilot study]. 61 54
9745197 1998
8
Thrombomodulin levels during normal pregnancy, at delivery and in the postpartum: comparison with tissue-type plasminogen activator and plasminogen activator inhibitor-1. 61 54
9531039 1998
9
Thrombomodulin, plasminogen activator inhibitor type 1 (PAI-1) and fibronectin as biomarkers of endothelial damage in preeclampsia and eclampsia. 61 54
8960994 1996
10
HLA-G deletion polymorphism and pre-eclampsia/eclampsia. 61 54
7547760 1995
11
Pregnancy induced hypertension and antithrombin-III. 54 61
8819656 1995
12
[Antithrombin ii in eclampsia: estimation of predictive value]. 54 61
1345066 1992
13
The Chronic Use of Magnesium Decreases VEGF Levels in the Uterine Tissue in Rats. 61
31701462 2020
14
Coronavirus disease-2019 in pregnancy with neurological manifestations versus pregnancy with eclampsia: Need for liberal testing to rule out the masquerades. 61
32473022 2020
15
Monitoring severe acute maternal morbidity across Europe: A feasibility study. 61
31502306 2020
16
Quality of care and maternal mortality in a tertiary-level hospital in Mozambique: a retrospective study of clinicopathological discrepancies. 61
32562652 2020
17
Maternal cardiac function in women at high risk for pre-eclampsia treated with 150 mg aspirin or placebo: an observational study. 61
32133780 2020
18
Severe maternal morbidity surveillance: Monitoring pregnant women at high risk for prolonged hospitalisation and death. 61
31407359 2020
19
Aspirin and pre-eclampsia: the heart of the matter? 61
32232916 2020
20
Re: Pravastatin for early-onset pre-eclampsia: a randomised, blinded, placebo-controlled trial. 61
32372433 2020
21
Preterm parturition and pre-eclampsia: The confluence of two great gestational syndromes. 61
32524594 2020
22
Maternal and perinatal outcomes of pregnancies in systemic lupus erythematosus: A nationwide population-based study. 61
32115237 2020
23
The association between ethnicity and pre-eclampsia in Australia: A multicentre retrospective cohort study. 61
31583696 2020
24
Antiphospholipid syndrome presenting as treatment resistant bipolar disorder and thrombocytopenia in a young male. 61
32305000 2020
25
Outcomes of pregnancy and associated factors in sub-Saharan African women with systemic lupus erythematosus: a scoping review. 61
32540928 2020
26
Building capacities of Auxiliary Nurse Midwives (ANMs) through a complementary mix of directed and self-directed skill-based learning-A case study in Pune District, Western India. 61
32552757 2020
27
New-onset epilepsy in women with first time seizures during pregnancy. 61
32521501 2020
28
Multivitamin use and risk of preeclampsia in a high-income population: A cohort study. 61
32086018 2020
29
Family history and risk of miscarriage: a systematic review and meta-analysis of observational studies. 61
32557529 2020
30
ABO O gene frequency increase in the US might be causing increased maternal mortality. 61
32540606 2020
31
Implementing self-management: a mixed methods study of women's experiences of a postpartum hypertension intervention (SNAP-HT). 61
32517785 2020
32
Technology-supported lifestyle interventions to improve maternal-fetal outcomes in women with gestational diabetes mellitus: A meta-analysis. 61
32193015 2020
33
IVF/ICSI treatment and the risk of iatrogenic preterm birth in singleton pregnancies: systematic review and meta-analysis of cohort studies. 61
32498576 2020
34
Aspirin, low molecular weight heparin, or both in preventing pregnancy complications in women with recurrent pregnancy loss and factor V Leiden mutation. 61
31550962 2020
35
Racial Disparity in Postpartum Readmission due to Hypertension among Women with Pregnancy-Associated Hypertension. 61
32485755 2020
36
Maternal Obesity and the Risk of Early-Onset and Late-Onset Hypertensive Disorders of Pregnancy. 61
32541276 2020
37
Association between ambient temperature and hypertensive disorders in pregnancy in China. 61
32522990 2020
38
Does sex matter? Association of fetal sex and parental age with pregnancy outcomes in Taiwan: a cohort study. 61
32513208 2020
39
Association of fetal gender and the onset and severity of hypertensive disorders of pregnancy. 61
32576066 2020
40
[Relationship between serum vitamin E concentration in first trimester and the risk of developing hypertension disorders complicating pregnancy]. 61
32541980 2020
41
Immediate postpartum management of patients with severe hypertensive disorders of pregnancy: pathophysiology guiding practice. 61
32519919 2020
42
Patterns of sociocognitive stratification and perinatal risk in the child brain. 61
32409600 2020
43
Maternal mortality risk indicators: Case-control study at a referral hospital in Guinea. 61
32554328 2020
44
Severe pre-eclamptic women with headache: is posterior reversible encephalopathy syndrome an associated concurrent finding? 61
32487027 2020
45
CXCL12 in normal and pathological pregnancies: A review. 61
32485053 2020
46
The Role of the IL-1 System in Pregnancy and the Use of IL-1 System Markers to Identify Women at Risk for Pregnancy Complications†. 61
32543660 2020
47
Identifying Risk Factors for Levels of Per- and Polyfluoroalkyl Substances (PFAS) in the Placenta in a High-Risk Pregnancy Cohort in North Carolina. 61
32469207 2020
48
Placental glycogen stores and fetal growth: insights from genetic mouse models. 61
32191912 2020
49
Periodontal diseases and adverse pregnancy outcomes: Mechanisms. 61
32385886 2020
50
Role of the small proteoglycan bikunin in human reproduction. 61
31728877 2020

Variations for Eclampsia

Expression for Eclampsia

Search GEO for disease gene expression data for Eclampsia.

Pathways for Eclampsia

Pathways related to Eclampsia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.3 VEGFA PGF FLT1
2 10.55 VEGFA SERPINC1 FLT1
3
Show member pathways
10 VEGFA PGF FLT1

GO Terms for Eclampsia

Cellular components related to Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 VEGFA TAC3 SERPINC1 PGF PAPPA OXT
2 extracellular space GO:0005615 9.36 VEGFA THBD TAC3 SERPINC1 PGF PAPPA

Biological processes related to Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.71 VEGFA PGF FLT1 ENG
2 positive regulation of angiogenesis GO:0045766 9.56 VEGFA PGF FLT1 ENG
3 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.54 VEGFA PGF FLT1
4 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.46 VEGFA FLT1
5 induction of positive chemotaxis GO:0050930 9.43 VEGFA PGF
6 vascular endothelial growth factor signaling pathway GO:0038084 9.33 VEGFA PGF FLT1
7 positive regulation of mast cell chemotaxis GO:0060754 9.32 VEGFA PGF
8 sprouting angiogenesis GO:0002040 9.26 VEGFA PGF FLT1 ENG
9 female pregnancy GO:0007565 9.1 THBD TAC3 PGF PAPPA OXT CORIN

Molecular functions related to Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vascular endothelial growth factor receptor binding GO:0005172 8.62 VEGFA PGF

Sources for Eclampsia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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