MCID: ECL001
MIFTS: 52

Eclampsia

Categories: Cardiovascular diseases, Nephrological diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Eclampsia

MalaCards integrated aliases for Eclampsia:

Name: Eclampsia 12 20 29 54 44 15 71 32
Eclampsia in Puerperium 12 71
Eclampsia, Postpartum 12
Postpartum Eclampsia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13593
MeSH 44 D004461
NCIt 50 C87167
SNOMED-CT 67 156111007
ICD10 32 O15 O15.2
UMLS 71 C0013537 C0156678

Summaries for Eclampsia

Disease Ontology : 12 A pre-eclampsia characterized by the presence of seizures.

MalaCards based summary : Eclampsia, also known as eclampsia in puerperium, is related to mild pre-eclampsia and severe pre-eclampsia, and has symptoms including seizures An important gene associated with Eclampsia is STOX1 (Storkhead Box 1), and among its related pathways/superpathways are Signaling events mediated by VEGFR1 and VEGFR2 and Glypican 1 network. The drugs Remifentanil and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include placenta, endothelial and kidney, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 74 Eclampsia is the onset of seizures (convulsions) in a woman with pre-eclampsia. Pre-eclampsia is a... more...

Related Diseases for Eclampsia

Diseases in the Eclampsia family:

Pre-Eclampsia Severe Pre-Eclampsia

Diseases related to Eclampsia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 559)
# Related Disease Score Top Affiliating Genes
1 mild pre-eclampsia 32.3 VEGFA STOX1 PGF PAPPA FLT1 ENG
2 severe pre-eclampsia 32.2 VEGFA SERPINC1 PGF PAPPA HLA-G
3 preeclampsia/eclampsia 1 32.1 SERPINC1 PEE1
4 hellp syndrome 30.9 VEGFA THBD SERPINC1 PGF MTHFR FLT1
5 hypertensive encephalopathy 30.9 VEGFA PGF FLT1 F2
6 peripartum cardiomyopathy 30.7 VEGFA PGF FLT1
7 disseminated intravascular coagulation 30.5 THBD SERPINC1 F2
8 chorioamnionitis 30.4 VEGFA OXT FLT1
9 thrombotic microangiopathy 30.4 VEGFA THBD
10 pulmonary edema 30.3 SERPINC1 OXT F2
11 retinal vascular disease 30.2 VEGFA PGF MTHFR FLT1
12 oligohydramnios 30.2 PGF PAPPA OXT
13 thrombophilia 30.1 THBD SERPINC1 MTHFR F2
14 placenta praevia 30.1 PGF PAPPA OXT F2
15 placental insufficiency 30.1 VEGFA SERPINC1 PGF PAPPA FLT1 F2
16 antiphospholipid syndrome 30.1 THBD SERPINC1 MTHFR F2
17 purpura 30.0 THBD SERPINC1 F2
18 intracranial hypertension 30.0 SERPINC1 MTHFR F2
19 hemolytic-uremic syndrome 29.8 THBD SERPINC1 F2
20 ectopic pregnancy 29.8 VEGFA PGF PAPPA FLT1
21 vascular disease 29.8 VEGFA THBD SERPINC1 MTHFR F2 ENG
22 thrombophlebitis 29.8 SERPINC1 MTHFR F2
23 microvascular complications of diabetes 5 29.8 VEGFA PGF FLT1
24 homocysteinemia 29.7 THBD SERPINC1 MTHFR F2
25 retinal vein occlusion 29.7 VEGFA SERPINC1 MTHFR F2
26 thrombophilia due to activated protein c resistance 29.6 THBD SERPINC1 MTHFR F2
27 papilledema 29.6 VEGFA SERPINC1 F2
28 antithrombin iii deficiency 29.6 SERPINC1 MTHFR F2
29 placental abruption 29.6 THBD SERPINC1 PGF PAPPA MTHFR HLA-G
30 thrombophilia due to thrombin defect 29.6 THBD SERPINC1 MTHFR F2
31 placenta disease 29.6 VEGFA SERPINC1 PGF PAPPA OXT MTHFR
32 hepatic infarction 29.5 SERPINC1 F2
33 thrombosis 29.4 THBD SERPINC1 MTHFR F2
34 portal vein thrombosis 29.4 SERPINC1 MTHFR F2
35 sagittal sinus thrombosis 29.4 SERPINC1 F2
36 pre-eclampsia 29.4 VEGFA THBD TAC3 STOX1 SERPINC1 PGF
37 budd-chiari syndrome 29.4 SERPINC1 MTHFR F2
38 intracranial hypotension 29.4 SERPINC1 F2
39 central retinal vein occlusion 29.3 VEGFA SERPINC1 MTHFR F2
40 diabetes mellitus 29.3 VEGFA THBD SERPINC1 PGF PAPPA MTHFR
41 protein s deficiency 29.3 THBD SERPINC1 MTHFR F2
42 protein c deficiency 29.3 THBD SERPINC1 MTHFR F2
43 atrial heart septal defect 29.2 SERPINC1 MTHFR F2
44 lipoprotein quantitative trait locus 29.2 VEGFA THBD PGF MTHFR F2 ENG
45 stroke, ischemic 29.1 THBD SERPINC1 MTHFR F2 ENG
46 pulmonary hypertension 29.1 VEGFA THBD SERPINC1 PGF FLT1 F2
47 pulmonary embolism 29.0 THBD SERPINC1 MTHFR F2
48 hypertension, essential 29.0 VEGFA THBD SERPINC1 PGF PAPPA OXT
49 peripheral vascular disease 28.9 VEGFA THBD SERPINC1 MTHFR F2
50 blood coagulation disease 28.9 VEGFA THBD SERPINC1 MTHFR F2

Graphical network of the top 20 diseases related to Eclampsia:



Diseases related to Eclampsia

Symptoms & Phenotypes for Eclampsia

UMLS symptoms related to Eclampsia:


seizures

MGI Mouse Phenotypes related to Eclampsia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 CORIN ENG F2 FLT1 NOSTRIN OXT
2 growth/size/body region MP:0005378 9.97 CORIN ENG F2 FLT1 INHBB MTHFR
3 homeostasis/metabolism MP:0005376 9.83 CORIN ENG EPHX1 F2 FLT1 HLA-G
4 digestive/alimentary MP:0005381 9.8 ENG F2 INHBB OXT TAC3 THBD
5 integument MP:0010771 9.28 CORIN ENG F2 INHBB MTHFR OXT

Drugs & Therapeutics for Eclampsia

Drugs for Eclampsia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 271)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Remifentanil Approved Phase 4 132875-61-7 60815
2
Azithromycin Approved Phase 4 83905-01-5 55185 447043
3
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
4
Nitric Oxide Approved Phase 4 10102-43-9 145068
5
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
6
Clonidine Approved Phase 4 4205-90-7 2803
7
Captopril Approved Phase 4 62571-86-2 44093
8
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
9
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
10
Isosorbide Dinitrate Approved, Investigational Phase 4 87-33-2 6883
11
AT-101 Approved, Investigational Phase 4 90141-22-3, 652-67-5 12597
12
Nifedipine Approved Phase 4 21829-25-4 4485
13
Enalaprilat Approved Phase 4 76420-72-9 6917719
14
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
15
Acetaminophen Approved Phase 4 103-90-2 1983
16
Ibuprofen Approved Phase 4 15687-27-1 3672
17
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
18
Metformin Approved Phase 4 657-24-9 14219 4091
19
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
20
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
21
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
22
Labetalol Approved Phase 4 36894-69-6 3869
23
Phenylephrine Approved Phase 4 59-42-7 6041
24
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
25
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
26
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
27 Vitamin D2 Phase 4
28 Ergocalciferols Phase 4
29 Anti-Bacterial Agents Phase 4
30 diuretics Phase 4
31 Sodium Potassium Chloride Symporter Inhibitors Phase 4
32 isosorbide-5-mononitrate Phase 4
33 Hormones Phase 4
34 Tocolytic Agents Phase 4
35 Calcium, Dietary Phase 4
36 calcium channel blockers Phase 4
37 Vasodilator Agents Phase 4
38 Angiotensin-Converting Enzyme Inhibitors Phase 4
39 Hormone Antagonists Phase 4
40 Narcotics Phase 4
41 11-hydroxyprogesterone Phase 4
42 Estrogens Phase 4
43 Estrogen Receptor Antagonists Phase 4
44 Estrogen Antagonists Phase 4
45 17 alpha-Hydroxyprogesterone Caproate Phase 4
46 Progestins Phase 4
47 Caproate Phase 4
48 Hypoglycemic Agents Phase 4
49 Sodium Channel Blockers Phase 4
50 Anesthetics, Local Phase 4

Interventional clinical trials:

(show top 50) (show all 536)
# Name Status NCT ID Phase Drugs
1 Effectiveness Of Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia: Randomized Placebo-Controlled Clinical Trial Unknown status NCT01361425 Phase 4 methildopa;placebo
2 Remifentanil for c-Section With General Anesthesia in Severe Preeclamptic Patients Unknown status NCT00567957 Phase 4 Remifentanil;Saline
3 A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Unknown status NCT02920593 Phase 4 Vitamin D3
4 Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features Unknown status NCT02911701 Phase 4 Acetaminophen;Ibuprofen
5 Low Dose Calcium Supplementation to Prevent Preeclampsia: a Cluster Randomized Study Unknown status NCT02338687 Phase 4
6 Impact of Antichlamydial Treatment on the Rate of Preeclampsia Among Egyptian Primigravidae: a Randomized Controlled Trial Unknown status NCT03233880 Phase 4 Azithromycin 1gm
7 Oral Nifedipine Versus Labetalol in Treatment of Postpartum Hypertension Unknown status NCT03449277 Phase 4 Oral Tablet
8 Continuation Versus Discontinuation of Magnesium Sulfate After Delivery in Women With Severe Preeclampsia. A Randomized Controlled Trial Unknown status NCT03318211 Phase 4 Magnesium Sulfate
9 Cardiovascular Performance and Autonomic Reactivity in Formerly Preeclamptic Women With a Contracted Plasma Volume (CAPACITY Trial) Unknown status NCT00117546 Phase 4 alpha methyldopa
10 Effect of Administering Intravenous Magnesium Sulfate Heptahydrate (MgSO4•7H2O) on Fetal Cardiotocography and Neonatal Outcome in Preeclamptic Patients in 3rd Trimester of Pregnancy Unknown status NCT03237000 Phase 4 MgSO4
11 Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Blockade in Gynaecology Patients Completed NCT01972659 Phase 4 placebo;Magnesium Sulphate;sugammadex
12 Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers Completed NCT01729468 Phase 4 Aspirin;Placebo
13 Evaluation of Dose-response Effect of Acetylsalicylic Acid on Placental Development, Preterm Birth, Fetal Growth and Hypertension in Pregnancy in Women With Previous History of Preeclampsia Completed NCT01352234 Phase 4 Acetylsalicylic Acid 160 mg;Acetylsalicylic Acid 80 mg
14 An Open-label Randomized-Controlled Trial of Early Screening Test for Pre-eclampsia and Growth Restriction Completed NCT03674606 Phase 4 Low dose aspirin
15 Efficacy and Safety of One Gram Versus Two Grams Intravenous Maintenance Dose of Magnesium Sulfate in Women With Severe Pre-eclampsia: a Randomized Clinical Trial. Completed NCT03164304 Phase 4 Magnesium Sulfate
16 A Randomized-controlled Trial to Assess the Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy Completed NCT02891174 Phase 4 Ibuprofen;Acetaminophen
17 Effectiveness of Postpartum Furosemide on Recovery Blood Pressure in Puerperal Women With Severe Preeclampsia: a Randomized Clinical Trial Completed NCT02163655 Phase 4 FUROSEMIDE;Placebo
18 Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy Completed NCT01912677 Phase 4 Nifedipine;Labetalol;Methyldopa
19 Treatment Approaches to Preeclampsia Completed NCT01030627 Phase 4
20 Randomized Clinical Trial for Effectiveness of Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure Completed NCT01761916 Phase 4 CLONIDINE;CAPTOPRIL
21 Ethnic Differences in Anti-Hypertensive Medication Response Among Pregnant and Postpartum Patients Completed NCT03506724 Phase 4 Nifedipine;Labetalol
22 Postpartum Prophylaxis With Short Course Magnesium Sulfate in Severe Preeclampsia: a Randomized Clinical Trial Completed NCT01408979 Phase 4 Magnesium sulfate 12 hours;Magnesium sulfate 24 hours
23 A Randomized Open-label Study to Compare the Clinical Outcomes and Magnesium Serum Concentrations Obtained in the Treatment of Severe Preeclampsia With a Repeat Bolus Intravenous Magnesium Sulfate Regimen Administered With the Springfusor Infusion Pump to a Continuous Intravenous Magnesium Sulfate Regimen Completed NCT02091401 Phase 4 Magnesium Sulfate
24 Adding Magnesium Sulphate to Epidural Levobupivacaine in Elective Caesarian Section for Patients With Preeclampsia Completed NCT02699827 Phase 4 Levobupivacaine hydrochloride;Magnesium sulphate;Saline 0.9%
25 Randomized Trial of Magnesium Sulfate in Obese Preeclamptic Women Completed NCT02835339 Phase 4 Magnesium sulfate 4g loading dose, 1g/hr infusion;Magnesium sulfate 6g loading dose, 2g/hr infusion
26 Randomized Controlled Trial of Nitric-oxide Donor (NOD) Isosorbide Mononitrate (IMN) Versus Placebo for Induction of Labor in Pregnancies Complicated by Preeclampsia Completed NCT03171480 Phase 4 Monoket Pill
27 Personalized Hemodynamically Guided Antihypertensive Treatment in Pregnant Women With Mild to Moderate Hypertension: a Randomized Controlled Trial Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
28 A Randomized Controlled Trial Comparing Nifedipine and Enalapril in Medical Resources Used in the Postpartum Period Recruiting NCT04236258 Phase 4 NIFEdipine ER;Enalapril
29 Metformin for Preeclampsia Prevention in Pregnant Women With Type 1 Diabetes Mellitus Recruiting NCT03570632 Phase 4 Metformin
30 Effect of Non-steroidal Anti-inflammatory Use on Blood Pressure in Women With Hypertensive Disorders of Pregnancy: A Randomized Open Label Trial Recruiting NCT03824119 Phase 4 Ibuprofen 600 mg
31 The Effect of 81mg vs 162mg ASA for Preeclampsia Prevention in Obese Women at High Risk for Developing Preeclampsia Recruiting NCT03735433 Phase 4 162mg aspirin dose
32 Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies--A Multicenter, Prospective, Open, Randomized, Controlled Clinical Trial Recruiting NCT04051567 Phase 4 Aspirin 100mg
33 Efficacy of 17-Hydroxyprogesterone Caproate in Expectantly Managed Early-onset Preeclampsia: A Randomized Controlled Study Recruiting NCT04077853 Phase 4 17 Hydroxyprogesterone Capronate
34 Nifedipine XL Versus Placebo for the Treatment of Preeclampsia With Severe Features During Induction of Labor Recruiting NCT04392375 Phase 4 Nifedipine 30 MG;Placebos
35 The Effectiveness of Low-dose Aspirin on Preventing Pre-eclampsia in High-risks Pregnant Women Not yet recruiting NCT04656665 Phase 4 Aspirin
36 A Prospective Randomized Clinical Research Trial Comparing the Incidence of Preeclampsia Between Pregnant Women Receiving Tdap Vaccinations at Week 28 and Those Receiving Tdap Vaccinations at Week 36 Not yet recruiting NCT04424693 Phase 4 Tdap Vaccine Administration
37 Lignocaine Nebulization for Attenuation of Intubation Stress Response in Patients With Severe Pre-eclampsia: a Prospective Double-blinded Placebo-controlled Trial Not yet recruiting NCT04441073 Phase 4 Lignocaine;Placebo
38 A Prospective Muti-center Study of Early Prediction and Randomised Prevention of Preeclampsia With Low Dose Aspirin in Chinese Cohort Not yet recruiting NCT04631627 Phase 4 Aspirin
39 Aspirin to Prevent Cardiac Dysfunction in Preeclampsia Not yet recruiting NCT04479072 Phase 4 Aspirin 81 mg;Placebo
40 Impact of Vasopressor Administration on Maternal and Neonatal Outcomes in Women With Pre-eclampsia Terminated NCT02025426 Phase 4 Phenylephrine;Ephedrine
41 Effectiveness and Safety of 1g/Hour vs. 2g/Hour of Magnesium Sulfate Maintenance Dose for Eclampsia Prevention: Randomized Clinical Trial Terminated NCT02396030 Phase 4 Magnesium sulfate 50% - 1g/h;Magnesium sulfate 50% - 2g/h
42 Acute Labetalol Use in Preeclampsia Randomized Trial Terminated NCT03872336 Phase 4 Experimental labetalol dose
43 Acute Control of Chronic Hypertension in Preeclampsia Terminated NCT03877692 Phase 4 Experimental dosing of labetalol
44 Clinical Effect of Atenativ Treatment on Uterine Blood Flow and the Amount of Atenativ Needed to Maintain a Normal Antithrombin Lvels During Two Weeks in Early and Severe Preeclampsia Withdrawn NCT02278575 Phase 4 Atenativ
45 A Pragmatic Randomized Study Comparing 81 mg Aspirin Versus 162 mg Aspirin in the Prevention of Preeclampsia During Pregnancy Withdrawn NCT04158830 Phase 4 Aspirin 81 mg Enteric Coated Tab - 1 tablet;Aspirin 81 mg Enteric Coated Tab - 2 tablets
46 Treatment of Severe Hypertension During Pre-Eclampsia.A Preliminary Equivalence Study Between URAPIDIL and NICARDIPINE Unknown status NCT00409253 Phase 3 URAPIDIL (EUPRESSYL*);NICARDIPINE
47 Use of Sildenafil Citrate in Management of Mild Pre-eclampsia: A Randomized Controlled Trial Unknown status NCT03262961 Phase 2, Phase 3 Sildenafil 20 MG;Placebo Oral Tablet
48 Oral Nifedipine Versus IV Labetalol in Treatment of Severe Pre Eclampsia in Pregnancy Unknown status NCT03325348 Phase 2, Phase 3 Nifedipine 10 mg;Labetalol
49 Carbetocin Versus Oxytocin for Prevention of Postpartum Hemorrhage in Patients With Severe Preeclampsia: a Double Blind Randomized Controlled Trial Unknown status NCT01382732 Phase 3 Carbetocin;Oxytocin
50 Prospects for the Prevention of Pregnancy-induced Hypertension and Preeclampsia (4P) - a Randomised, Placebo-controlled, Double-blind Clinical Trial Unknown status NCT02007837 Phase 3 Combined aspirin and multinutrient supplement

Search NIH Clinical Center for Eclampsia

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Magnesium Sulfate
Nitroglycerin

Cochrane evidence based reviews: eclampsia

Genetic Tests for Eclampsia

Genetic tests related to Eclampsia:

# Genetic test Affiliating Genes
1 Eclampsia 29

Anatomical Context for Eclampsia

MalaCards organs/tissues related to Eclampsia:

40
Placenta, Endothelial, Kidney, Thyroid, Ovary, Neutrophil, Liver

Publications for Eclampsia

Articles related to Eclampsia:

(show top 50) (show all 15667)
# Title Authors PMID Year
1
Correlation between maternal plasma thrombomodulin and infant birth weight in hypertensive disorders of pregnancy. 54 61
19022800 2009
2
Evaluation of natural coagulation inhibitor levels in various hypertensive states of pregnancy. 54 61
15893867 2005
3
Absence of Factor V Leiden, thrombomodulin and prothrombin gene variants in Black South African women with pre-eclampsia and eclampsia. 61 54
12628278 2003
4
[Folic acid levels, homocysteine and polymorphism of methylenetetrahydrofolate reductase enzyme (MTHFR) in patients with pre-eclampsia and eclampsia]. 54 61
11268732 2001
5
Methylenetetrahydrofolate reductase 677 C --> T polymorphism, plasma folate, vitamin B(12) concentrations, and risk of preeclampsia among black African women from Zimbabwe. 61 54
10655155 2000
6
Methylenetetrahydrofolate reductase polymorphisms are not a risk factor for pre-eclampsia/eclampsia in Australian women. 61 54
10965192 2000
7
[Antithrombin-III in preeclampsia-eclampsia. Pilot study]. 61 54
9745197 1998
8
Thrombomodulin levels during normal pregnancy, at delivery and in the postpartum: comparison with tissue-type plasminogen activator and plasminogen activator inhibitor-1. 54 61
9531039 1998
9
Thrombomodulin, plasminogen activator inhibitor type 1 (PAI-1) and fibronectin as biomarkers of endothelial damage in preeclampsia and eclampsia. 54 61
8960994 1996
10
HLA-G deletion polymorphism and pre-eclampsia/eclampsia. 54 61
7547760 1995
11
Pregnancy induced hypertension and antithrombin-III. 54 61
8819656 1995
12
[Antithrombin ii in eclampsia: estimation of predictive value]. 61 54
1345066 1992
13
Outcome of pregnancies with marginal umbilical cord insertion. 61
31164018 2021
14
HDAC2-mediated proliferation of trophoblast cells requires the miR-183/FOXA1/IL-8 signaling pathway. 61
33164209 2021
15
Placental pathology and neonatal outcomes in pre-eclampsia with gestational diabetes mellitus. 61
32627623 2021
16
Risk of type 2 diabetes mellitus in women with prior hypertensive disorders of pregnancy: a systematic review and meta-analysis. 61
33409572 2021
17
Correlation of serum collectrin level and preeclampsia onset: A case control study. 61
32325273 2021
18
Preeclampsia before 26 weeks of gestation: Obstetrical prognosis for the subsequent pregnancy. 61
33221560 2021
19
Stroke in Pregnancy: A Multidisciplinary Approach. 61
33573791 2021
20
Relationship between LPA SNPs and inflammatory burden in patients with preeclampsia to address future cardiovascular risk. 61
31113255 2021
21
Energy deficiency caused by CTPS downregulation in decidua may contribute to pre-eclampsia by impairing decidualization. 61
33576499 2021
22
Second and third trimester serum levels of HtrA1 in pregnancies affected by pre-eclampsia. 61
33601219 2021
23
Oxidative stress-related genes (EPHX1 and MnSOD) polymorphism and risk of pre-eclampsia: a meta-analysis. 61
33586574 2021
24
A five-year trend in pre-eclampsia admission and factors associated with inpatient eclampsia: a retrospective study from a resource-limited hospital in northeast Ethiopia. 61
33550234 2021
25
Insufficient iodine nutrition status and the risk of pre-eclampsia: a systemic review and meta-analysis. 61
33568375 2021
26
Systemic transcriptome comparison between early- And late-onset pre-eclampsia shows distinct pathology and novel biomarkers. 61
33332660 2021
27
Prediction of pre-eclampsia in twin pregnancy by maternal factors and biomarkers at 11-13 weeks' gestation: data from EVENTS trial. 61
33142361 2021
28
Midwives' knowledge of pre-eclampsia management: A scoping review. 61
32928690 2021
29
Maternal Serum Zinc Level and Pre-eclampsia Risk in African Women: a Systematic Review and Meta-analysis. 61
33527339 2021
30
Incidence of postpartum hypertension within 2 years of a pregnancy complicated by pre-eclampsia: a systematic review and meta-analysis. 61
32981216 2021
31
Expression of plasma nuclear factor-kappa B cells (NF-κB) and Inhibitory subunit kappa B alpha (IκB-α) in HIV-associated pre-eclampsia. 61
33397161 2021
32
Clinical characteristics and prognosis of postpartum acute kidney injury. 61
33583276 2021
33
miR-219a suppresses human trophoblast cell invasion and proliferation by targeting vascular endothelial growth factor receptor 2 (VEGFR2). 61
33405003 2021
34
Exploring the role of non-coding RNAs in autophagy. 61
33525971 2021
35
The Preparing Residents for International Medical Experiences (PRIME) Simulation Workshop: Equipping Surgery and Anesthesia Trainees for International Rotations. 61
33598534 2021
36
Know-do gaps in obstetric and newborn care quality in Uganda: a cross-sectional study in rural health centers. 61
33529436 2021
37
Influence of birth weight on fetal cardiac indices at 35-37 weeks' gestation. 61
33094501 2021
38
Untargeted analysis of first trimester serum to reveal biomarkers of pregnancy complications: a case-control discovery phase study. 61
33568690 2021
39
Angiogenic Effect of Pravastatin Alone and with Sera from Healthy and Complicated Pregnancies Studied by in vitro Vasculogenesis/Angiogenesis Assay. 61
33571991 2021
40
Sleep-Disordered Breathing and Pregnancy-Related Cardiovascular Disease. 61
33181042 2021
41
Association of Maternal Hyperuricemia with Post-Spinal Hypotension in Pre-Eclamptic Parturients Undergoing Emergency Cesarean Delivery: a Prospective Observational Study. 61
33021697 2021
42
Regulatory mechanism of miR-525-5p in over-invasion of trophoblast. 61
33258220 2021
43
Pernicious pregnancy: Type B aortic dissection in pregnant women. 61
33533078 2021
44
Primary hyperparathyroidism and Zollinger Ellison syndrome during pregnancy: a case report. 61
33597314 2021
45
Predicting factors of adverse pregnancy outcomes in Thai patients with systemic lupus erythematosus: A STROBE-compliant study. 61
33592909 2021
46
Birthweight and other perinatal outcomes of singletons conceived after assisted reproduction compared to natural conceived singletons in couples with unexplained subfertility: follow-up of two randomized clinical trials. 61
33347597 2021
47
Uterine natural killer cells: from foe to friend in reproduction. 61
33528013 2021
48
Impact of SARS-CoV-2 on multiple gestation pregnancy. 61
33259652 2021
49
Endometriosis and Risk of Adverse Pregnancy Outcome: A Systematic Review and Meta-Analysis. 61
33572322 2021
50
Birth hospital and racial and ethnic differences in severe maternal morbidity in the state of California. 61
32798461 2021

Variations for Eclampsia

Expression for Eclampsia

Search GEO for disease gene expression data for Eclampsia.

Pathways for Eclampsia

Pathways related to Eclampsia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.3 VEGFA PGF FLT1
2 10.55 VEGFA SERPINC1 FLT1
3 10.43 F2 EPHX1
4
Show member pathways
10 VEGFA PGF FLT1

GO Terms for Eclampsia

Cellular components related to Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 VEGFA TAC3 SERPINC1 PGF PAPPA OXT
2 extracellular space GO:0005615 9.4 VEGFA THBD TAC3 SERPINC1 PGF PAPPA

Biological processes related to Eclampsia according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.95 VEGFA STOX1 PGF FLT1 F2
2 angiogenesis GO:0001525 9.81 VEGFA PGF FLT1 ENG
3 positive regulation of protein phosphorylation GO:0001934 9.73 VEGFA PGF F2 ENG
4 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.71 VEGFA FLT1 F2
5 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.63 VEGFA PGF FLT1
6 response to hypoxia GO:0001666 9.62 VEGFA PGF MTHFR ENG
7 induction of positive chemotaxis GO:0050930 9.56 VEGFA PGF
8 positive regulation of angiogenesis GO:0045766 9.56 VEGFA PGF FLT1 ENG
9 hemostasis GO:0007599 9.54 THBD SERPINC1 F2
10 regulation of blood coagulation GO:0030193 9.52 SERPINC1 F2
11 negative regulation of fibrinolysis GO:0051918 9.49 THBD F2
12 negative regulation of platelet activation GO:0010544 9.48 THBD F2
13 positive regulation of mast cell chemotaxis GO:0060754 9.4 VEGFA PGF
14 sprouting angiogenesis GO:0002040 9.33 VEGFA PGF ENG
15 vascular endothelial growth factor signaling pathway GO:0038084 9.13 VEGFA PGF FLT1
16 female pregnancy GO:0007565 9.02 THBD TAC3 PAPPA OXT CORIN

Molecular functions related to Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.26 VEGFA SERPINC1 PGF F2
2 vascular endothelial growth factor receptor binding GO:0005172 9.16 VEGFA PGF
3 growth factor activity GO:0008083 8.92 VEGFA PGF INHBB F2

Sources for Eclampsia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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