MCID: ECL001
MIFTS: 51

Eclampsia

Categories: Cardiovascular diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Eclampsia

MalaCards integrated aliases for Eclampsia:

Name: Eclampsia 12 52 29 54 43 15 71 32
Eclampsia in Puerperium 12 71
Eclampsia, Postpartum 12
Postpartum Eclampsia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13593
MeSH 43 D004461
NCIt 49 C87167
SNOMED-CT 67 15938005
ICD10 32 O15 O15.2 O15.9
UMLS 71 C0013537 C0156678

Summaries for Eclampsia

Disease Ontology : 12 A pre-eclampsia characterized by the presence of seizures.

MalaCards based summary : Eclampsia, also known as eclampsia in puerperium, is related to preeclampsia/eclampsia 1 and severe pre-eclampsia, and has symptoms including seizures An important gene associated with Eclampsia is STOX1 (Storkhead Box 1), and among its related pathways/superpathways are Signaling events mediated by VEGFR1 and VEGFR2 and Glypican 1 network. The drugs Magnesium oxide and Magnesium Sulfate have been mentioned in the context of this disorder. Affiliated tissues include placenta, endothelial and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Eclampsia is the onset of seizures (convulsions) in a woman with pre-eclampsia. Pre-eclampsia is a... more...

Related Diseases for Eclampsia

Diseases in the Eclampsia family:

Pre-Eclampsia Severe Pre-Eclampsia

Diseases related to Eclampsia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 506)
# Related Disease Score Top Affiliating Genes
1 preeclampsia/eclampsia 1 33.8 SERPINC1 PEE1
2 severe pre-eclampsia 33.3 VEGFA SERPINC1 PGF PAPPA LGALS13 HLA-G
3 mild pre-eclampsia 33.2 VEGFA PGF PAPPA OXT LGALS13 FLT1
4 hypertensive encephalopathy 31.2 VEGFA PGF
5 hellp syndrome 31.2 VEGFA THBD SERPINC1 PGF MTHFR LGALS13
6 peripartum cardiomyopathy 30.9 VEGFA PGF FLT1
7 patau syndrome 30.6 PGF PAPPA LGALS13
8 chorioamnionitis 30.5 VEGFA OXT FLT1
9 retinal vascular disease 30.4 VEGFA PGF MTHFR FLT1
10 exudative vitreoretinopathy 1 30.3 VEGFA PGF FLT1
11 oligohydramnios 30.2 PGF PAPPA OXT
12 pre-eclampsia 30.1 VEGFA THBD TAC3 STOX1 SERPINC1 PGF
13 placental insufficiency 30.1 VEGFA SERPINC1 PGF PAPPA FLT1
14 pregnancy loss, recurrent 1 30.1 MTHFR HLA-G
15 antiphospholipid syndrome 30.0 THBD SERPINC1 PGF MTHFR
16 ectopic pregnancy 30.0 VEGFA PGF PAPPA FLT1
17 microvascular complications of diabetes 5 29.9 VEGFA PGF FLT1
18 vascular disease 29.8 VEGFA THBD SERPINC1 MTHFR ENG
19 retinal vein occlusion 29.8 VEGFA SERPINC1 MTHFR
20 thrombophilia due to thrombin defect 29.8 THBD SERPINC1 MTHFR
21 thrombophilia due to activated protein c resistance 29.8 THBD SERPINC1 MTHFR
22 homocysteinemia 29.7 THBD SERPINC1 MTHFR
23 placenta accreta 29.6 PGF PAPPA OXT FLT1
24 placental abruption 29.4 THBD SERPINC1 PGF PAPPA MTHFR HLA-G
25 central retinal vein occlusion 29.4 VEGFA SERPINC1 MTHFR
26 protein s deficiency 29.4 THBD SERPINC1 MTHFR
27 protein c deficiency 29.4 THBD SERPINC1 MTHFR
28 placenta disease 29.3 VEGFA SERPINC1 PGF PAPPA OXT MTHFR
29 stroke, ischemic 29.2 THBD SERPINC1 MTHFR ENG
30 pulmonary embolism 29.1 THBD SERPINC1 MTHFR
31 peripheral vascular disease 29.0 VEGFA THBD SERPINC1 ENG
32 blood coagulation disease 29.0 VEGFA THBD SERPINC1 MTHFR
33 malaria 28.7 VEGFA THBD SERPINC1 MTHFR FLT1 ENG
34 hypertension, essential 28.6 VEGFA THBD SERPINC1 PGF PAPPA OXT
35 myocardial infarction 28.2 VEGFA THBD SERPINC1 PGF PAPPA MTHFR
36 preeclampsia/eclampsia 4 12.7
37 preeclampsia/eclampsia 5 12.7
38 preeclampsia/eclampsia 2 12.4
39 preeclampsia/eclampsia 3 12.4
40 gestational diabetes 11.6
41 chorea gravidarum 11.2
42 encephalopathy 10.7
43 yemenite deaf-blind hypopigmentation syndrome 10.6
44 disseminated intravascular coagulation 10.6
45 acute kidney failure 10.6
46 hydrops, lactic acidosis, and sideroblastic anemia 10.6
47 thrombocytopenia 10.5
48 hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy 10.5
49 hemifacial spasm 10.5 VEGFA MTHFR
50 pulmonary edema 10.5

Graphical network of the top 20 diseases related to Eclampsia:



Diseases related to Eclampsia

Symptoms & Phenotypes for Eclampsia

UMLS symptoms related to Eclampsia:


seizures

MGI Mouse Phenotypes related to Eclampsia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.9 CORIN ENG FLT1 INHBB NOSTRIN OXT
2 homeostasis/metabolism MP:0005376 9.8 CORIN ENG EPHX1 FLT1 HLA-G INHBB
3 integument MP:0010771 9.23 CORIN ENG INHBB MTHFR OXT PGF

Drugs & Therapeutics for Eclampsia

Drugs for Eclampsia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 366)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Magnesium oxide Approved Phase 4 1309-48-4 14792
2
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Dinoprostone Approved Phase 4 363-24-6 5280360
5
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
6
leucovorin Approved Phase 4 58-05-9 6006 143
7
Remifentanil Approved Phase 4 132875-61-7 60815
8
Enoxaparin Approved Phase 4 9005-49-6 772
9
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
10
Dalteparin Approved Phase 4 9005-49-6
11
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
12
Scopolamine Approved, Investigational Phase 4 51-34-3, 6533-68-2 5184
13
Clonidine Approved Phase 4 4205-90-7 2803
14
Procaterol Approved, Investigational Phase 4 72332-33-3 688561
15
Captopril Approved Phase 4 62571-86-2 44093
16
Carbetocin Approved, Investigational Phase 4 37025-55-1 71715 16681432
17
Phenylephrine Approved Phase 4 59-42-7 6041
18
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
19
Acetaminophen Approved Phase 4 103-90-2 1983
20
Ibuprofen Approved Phase 4 15687-27-1 3672
21
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
22
Azithromycin Approved Phase 4 83905-01-5 55185 447043
23
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
24
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
25
Alprostadil Approved, Investigational Phase 4 745-65-3 149351 5280723
26
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
27
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
28
Desogestrel Approved Phase 4 54024-22-5 40973
29
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
30
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
31
Metformin Approved Phase 4 657-24-9 14219 4091
32
Zinc Approved, Investigational Phase 4 7440-66-6 32051
33
Glyburide Approved Phase 4 10238-21-8 3488
34
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
35 Tocolytic Agents Phase 4
36 Anti-Arrhythmia Agents Phase 4
37 Anticonvulsants Phase 4
38 calcium channel blockers Phase 4
39 Antihypertensive Agents Phase 4
40 Antiemetics Phase 4
41 Autonomic Agents Phase 4
42 Adrenergic Agonists Phase 4
43 Adrenergic Agents Phase 4
44 Anesthetics, Local Phase 4
45 Sodium Channel Blockers Phase 4
46 Diuretics, Potassium Sparing Phase 4
47 Adrenergic alpha-2 Receptor Agonists Phase 4
48 calcium heparin Phase 4
49 Sympatholytics Phase 4
50 Angiotensin-Converting Enzyme Inhibitors Phase 4

Interventional clinical trials:

(show top 50) (show all 637)
# Name Status NCT ID Phase Drugs
1 Low Dose Calcium Supplementation to Prevent Preeclampsia: a Cluster Randomized Study Unknown status NCT02338687 Phase 4
2 Remifentanil for c-Section With General Anesthesia in Severe Preeclamptic Patients Unknown status NCT00567957 Phase 4 Remifentanil;Saline
3 Effectiveness Of Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia: Randomized Placebo-Controlled Clinical Trial Unknown status NCT01361425 Phase 4 methildopa;placebo
4 Cardiovascular Performance and Autonomic Reactivity in Formerly Preeclamptic Women With a Contracted Plasma Volume (CAPACITY Trial) Unknown status NCT00117546 Phase 4 alpha methyldopa
5 Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features Unknown status NCT02911701 Phase 4 Acetaminophen;Ibuprofen
6 Continuation Versus Discontinuation of Magnesium Sulfate After Delivery in Women With Severe Preeclampsia. A Randomized Controlled Trial Unknown status NCT03318211 Phase 4 Magnesium Sulfate
7 A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Unknown status NCT02920593 Phase 4 Vitamin D3
8 Magnesium Deficiency in Cirrhotic Patients Unknown status NCT01894867 Phase 4
9 Effect of Administering Intravenous Magnesium Sulfate Heptahydrate (MgSO4•7H2O) on Fetal Cardiotocography and Neonatal Outcome in Preeclamptic Patients in 3rd Trimester of Pregnancy Unknown status NCT03237000 Phase 4 MgSO4
10 Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers Completed NCT01729468 Phase 4 Aspirin;Placebo
11 An Open-label Randomized-Controlled Trial of Early Screening Test for Pre-eclampsia and Growth Restriction Completed NCT03674606 Phase 4 Low dose aspirin
12 Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Blockade in Gynaecology Patients Completed NCT01972659 Phase 4 placebo;Magnesium Sulphate;sugammadex
13 Evaluation of Dose-response Effect of Acetylsalicylic Acid on Placental Development, Preterm Birth, Fetal Growth and Hypertension in Pregnancy in Women With Previous History of Preeclampsia Completed NCT01352234 Phase 4 Acetylsalicylic Acid 160 mg;Acetylsalicylic Acid 80 mg
14 A Randomized Open-label Study to Compare the Clinical Outcomes and Magnesium Serum Concentrations Obtained in the Treatment of Severe Preeclampsia With a Repeat Bolus Intravenous Magnesium Sulfate Regimen Administered With the Springfusor Infusion Pump to a Continuous Intravenous Magnesium Sulfate Regimen Completed NCT02091401 Phase 4 Magnesium Sulfate
15 Postpartum Prophylaxis With Short Course Magnesium Sulfate in Severe Preeclampsia: a Randomized Clinical Trial Completed NCT01408979 Phase 4 Magnesium sulfate 12 hours;Magnesium sulfate 24 hours
16 A Randomized-controlled Trial to Assess the Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy Completed NCT02891174 Phase 4 Ibuprofen;Acetaminophen
17 Effectiveness of Postpartum Furosemide on Recovery Blood Pressure in Puerperal Women With Severe Preeclampsia: a Randomized Clinical Trial Completed NCT02163655 Phase 4 FUROSEMIDE;Placebo
18 Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy Completed NCT01912677 Phase 4 Nifedipine;Labetalol;Methyldopa
19 Adding Magnesium Sulphate to Epidural Levobupivacaine in Elective Caesarian Section for Patients With Preeclampsia Completed NCT02699827 Phase 4 Levobupivacaine hydrochloride;Magnesium sulphate;Saline 0.9%
20 Treatment Approaches to Preeclampsia Completed NCT01030627 Phase 4
21 Randomized Trial of Magnesium Sulfate in Obese Preeclamptic Women Completed NCT02835339 Phase 4 Magnesium sulfate 4g loading dose, 1g/hr infusion;Magnesium sulfate 6g loading dose, 2g/hr infusion
22 Efficacy and Safety of Hyoscine N Butyl Bromide on the Augmentation of Labor: a Double-Blind, Placebo - Controlled Trial Completed NCT02098889 Phase 4 hyoscine-N-butyl bromide(HBB);Saline
23 Antepartum Study on Use of Interpersonal Psychotherapy at 3 New York City Sites Completed NCT00251043 Phase 4
24 Ethnic Differences in Anti-Hypertensive Medication Response Among Pregnant and Postpartum Patients Completed NCT03506724 Phase 4 Nifedipine;Labetalol
25 A Prospective Multi-centre Randomised Comparison on Induction of Labour With Double-balloon Installation Device Versus Prostaglandin E2 Minprostin Completed NCT01255839 Phase 4 Minprostin
26 Low Molecular Weight Heparin for Treatment of Recurrent Miscarriage With Negative Antiphospholipid Antibodies: a Randomized Controlled Trial Completed NCT01608347 Phase 4 LMWH+Folic acid;Folic Acid
27 Effect of Intravenous Infusion of Lidocaine, Magnesium Sulphate and Remifentanil Perioperatively in Patients Undergoing Mastectomy: a Prospective, Randomized and Double-blind Study Completed NCT02309879 Phase 4 Remifentanil infusion;Lidocaine infusion;Magnesium sulphate infusion;Magnesium sulphate and Lidocaine infusion
28 Albuterol Dose-Response on Pulmonary Function Testing in Preterm Infants at Risk of Bronchopulmonary Dysplasia Completed NCT02447250 Phase 4 Varied albuterol dose response
29 Randomized Clinical Trial for Effectiveness of Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure Completed NCT01761916 Phase 4 CLONIDINE;CAPTOPRIL
30 Effect of Myofascial Release on Electrophysiological and Clinical Measures of Pregnant Women With Carpal Tunnel Syndrome Completed NCT03802448 Phase 4
31 Impact of Vasopressor Administration on Maternal and Neonatal Outcomes in Women With Pre-eclampsia Recruiting NCT02025426 Phase 4 Phenylephrine;Ephedrine
32 Oral Nifedipine Versus Labetalol in Treatment of Postpartum Hypertension Recruiting NCT03449277 Phase 4 Oral Tablet
33 Efficacy and Safety of One Gram Versus Two Grams Intravenous Maintenance Dose of Magnesium Sulfate in Women With Severe Pre-eclampsia: a Randomized Clinical Trial. Recruiting NCT03164304 Phase 4 Magnesium Sulfate
34 Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies--A Multicenter, Prospective, Open, Randomized, Controlled Clinical Trial Recruiting NCT04051567 Phase 4 Aspirin 100mg
35 Personalized Hemodynamically Guided Antihypertensive Treatment in Pregnant Women With Mild to Moderate Hypertension: a Randomized Controlled Trial Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
36 Impact of Antichlamydial Treatment on the Rate of Preeclampsia Among Egyptian Primigravidae: a Randomized Controlled Trial Recruiting NCT03233880 Phase 4 Azithromycin 1gm
37 The Effect of 81mg vs 162mg ASA for Preeclampsia Prevention in Obese Women at High Risk for Developing Preeclampsia Recruiting NCT03735433 Phase 4 162mg aspirin dose
38 Metformin for Preeclampsia Prevention in Pregnant Women With Type 1 Diabetes Mellitus Recruiting NCT03570632 Phase 4 Metformin
39 Acute Control of Chronic Hypertension in Preeclampsia Recruiting NCT03877692 Phase 4 Experimental dosing of labetalol
40 Acute Labetalol Use in Preeclampsia Randomized Trial Recruiting NCT03872336 Phase 4 Experimental labetalol dose
41 Carbetocin Versus Misoprostol for Prevention of Postpartum Hemorrhage in Pregnant Women at High Risk Following C.S. Recruiting NCT02277067 Phase 4 Carbetocin;Misoprostol
42 Interaction Between Intravenous Magnesium Sulphate and Neostigmine or Sugammadex for the Reversal of a Rocuronium-induced Neuromuscular Block - A Randomized, Double Blinded, Electrophysiological Study Recruiting NCT03497923 Phase 4 Magnesium Sulfate
43 Effect of Non-steroidal Anti-inflammatory Use on Blood Pressure in Women With Hypertensive Disorders of Pregnancy: A Randomized Open Label Trial Recruiting NCT03824119 Phase 4 Ibuprofen 600 mg
44 The Effect of Antibiotics on Latency in Previable Prelabor Rupture of Membranes Between 18 0/7 and 22 6/7 Weeks Gestational Age Recruiting NCT04047849 Phase 4 Antibiotics, oral Azithromycin and oral Amoxicillin
45 Use of Etonogestrel-releasing Contraceptive Implant in Women With Sickle Cell Disease Active, not recruiting NCT02594462 Phase 4 etonogestrel-releasing implant contraceptive
46 Efficacy of 17-Hydroxyprogesterone Caproate in Expectantly Managed Early-onset Preeclampsia: A Randomized Controlled Study Not yet recruiting NCT04077853 Phase 4 17 Hydroxyprogesterone Capronate
47 Threshold for Initiation of Medical Treatment for Women With Gestational Diabetes: A Single Site Randomized Trial Not yet recruiting NCT03527537 Phase 4 Insulin;Glyburide;Metformin
48 Magnesium Infusion for Pain Management in Critically Ill Trauma Patients Not yet recruiting NCT04166877 Phase 4 Magnesium Sulfate in Parenteral Dosage Form;Normal saline placebo
49 A Pragmatic Randomized Study Comparing 81 mg Aspirin Versus 162 mg Aspirin in the Prevention of Preeclampsia During Pregnancy Not yet recruiting NCT04158830 Phase 4 Aspirin 81 mg Enteric Coated Tab - 1 tablet;Aspirin 81 mg Enteric Coated Tab - 2 tablets
50 Effectiveness and Safety of 1g/Hour vs. 2g/Hour of Magnesium Sulfate Maintenance Dose for Eclampsia Prevention: Randomized Clinical Trial Terminated NCT02396030 Phase 4 Magnesium sulfate 50% - 1g/h;Magnesium sulfate 50% - 2g/h

Search NIH Clinical Center for Eclampsia

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Magnesium Sulfate
Nitroglycerin

Cochrane evidence based reviews: eclampsia

Genetic Tests for Eclampsia

Genetic tests related to Eclampsia:

# Genetic test Affiliating Genes
1 Eclampsia 29

Anatomical Context for Eclampsia

MalaCards organs/tissues related to Eclampsia:

40
Placenta, Endothelial, Testes, Liver, Kidney, Heart, Brain

Publications for Eclampsia

Articles related to Eclampsia:

(show top 50) (show all 14864)
# Title Authors PMID Year
1
Correlation between maternal plasma thrombomodulin and infant birth weight in hypertensive disorders of pregnancy. 54 61
19022800 2009
2
Evaluation of natural coagulation inhibitor levels in various hypertensive states of pregnancy. 54 61
15893867 2005
3
Absence of Factor V Leiden, thrombomodulin and prothrombin gene variants in Black South African women with pre-eclampsia and eclampsia. 54 61
12628278 2003
4
[Folic acid levels, homocysteine and polymorphism of methylenetetrahydrofolate reductase enzyme (MTHFR) in patients with pre-eclampsia and eclampsia]. 54 61
11268732 2001
5
Methylenetetrahydrofolate reductase polymorphisms are not a risk factor for pre-eclampsia/eclampsia in Australian women. 54 61
10965192 2000
6
Methylenetetrahydrofolate reductase 677 C --> T polymorphism, plasma folate, vitamin B(12) concentrations, and risk of preeclampsia among black African women from Zimbabwe. 54 61
10655155 2000
7
[Antithrombin-III in preeclampsia-eclampsia. Pilot study]. 54 61
9745197 1998
8
Thrombomodulin levels during normal pregnancy, at delivery and in the postpartum: comparison with tissue-type plasminogen activator and plasminogen activator inhibitor-1. 54 61
9531039 1998
9
Thrombomodulin, plasminogen activator inhibitor type 1 (PAI-1) and fibronectin as biomarkers of endothelial damage in preeclampsia and eclampsia. 54 61
8960994 1996
10
HLA-G deletion polymorphism and pre-eclampsia/eclampsia. 54 61
7547760 1995
11
Pregnancy induced hypertension and antithrombin-III. 54 61
8819656 1995
12
[Antithrombin ii in eclampsia: estimation of predictive value]. 54 61
1345066 1992
13
MicroRNAs: Small molecules with a large impact on pre-eclampsia. 61
31595979 2020
14
Postpartum length of stay and risk for readmission among women with preeclampsia. 61
30122116 2020
15
Gut dysbiosis induces the development of pre-eclampsia through bacterial translocation. 61
31900289 2020
16
The pre-gestational triglycerides and high-density lipoprotein cholesterol ratio is associated with adverse perinatal outcomes: A retrospective cohort analysis. 61
31811728 2020
17
ROS/p53/miR‑335‑5p/Sp1 axis modulates the migration and epithelial to mesenchymal transition of JEG‑3 cells. 61
31894323 2020
18
Effects of maternal and fetal vascular endothelial growth factor a single nucleotide polymorphisms on pre-eclampsia: A hybrid design study. 61
31951964 2020
19
Abnormal uterine inflammation in obstetric syndromes: molecular insights into the role of chemokine decoy receptor D6 and inflammasome NLRP3. 61
32030415 2020
20
Cost Effectiveness of Antenatal Lifestyle Interventions for Preventing Gestational Diabetes and Hypertensive Disease in Pregnancy. 61
32026397 2020
21
Pregnancy outcomes in women with primary biliary cholangitis and primary sclerosing cholangitis: A retrospective cohort study. 61
32012415 2020
22
Transfer of Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome by a Liver Graft From a Pregnant Female Donor to a Male Recipient: A Case Report. 61
32035676 2020
23
Systematic review with meta-analysis: risk of adverse pregnancy-related outcomes in inflammatory bowel disease. 61
31912546 2020
24
Liver Disease in Pregnancy: What's New. 61
32025601 2020
25
LRP6 regulates Rab7-mediated autophagy through the Wnt/β-catenin pathway to modulate trophoblast cell migration and invasion. 61
31544984 2020
26
The correlation between PM2.5 exposure and hypertensive disorders in pregnancy: A Meta-analysis. 61
31731170 2020
27
Trends and predictors of gestational diabetes mellitus in Chile. 61
31671205 2020
28
Maternal plasma proteomics in a rat model of pregnancy complications reveals immune and pro-coagulant gene pathway activation. 61
31677200 2020
29
Effects of laparoscopic sleeve gastrectomy on obstetric outcomes within 12 months after surgery. 61
31770822 2020
30
Anatomical and physiological alterations of pregnancy. 61
32026239 2020
31
Placental growth factor testing in suspected pre-eclampsia. 61
32007161 2020
32
Placental growth factor testing in suspected pre-eclampsia. 61
32007162 2020
33
Placental growth factor testing in suspected pre-eclampsia - Authors' reply. 61
32007163 2020
34
Choroidal Thickness in Pre-eclampsia. 61
31581857 2020
35
Subfoveal Choroidal Thickness in Pre-eclampsia. 61
32011579 2020
36
Hypomethylation of CTGF Promoter in Placenta and Peripheral Blood of Pre-eclampsia Women. 61
32016800 2020
37
Evaluation of placental chorionic villi histone 2A expression in HIV-infected women with pre-eclampsia. 61
31901600 2020
38
Ocular sonography in pre-eclampsia: a simple technique to detect raised intracranial pressure? 61
31704252 2020
39
Association between Vascular Endothelial Growth Factor Gene Polymorphisms and Pre-Eclampsia Susceptibility: An Updated Meta-Analysis. 61
31455120 2020
40
Family history of pre-eclampsia and cardiovascular disease as risk factors for pre-eclampsia: the GenPE case-control study. 61
31910697 2020
41
A pilot study of alterations in oxidized angiotensinogen and antioxidants in pre-eclamptic pregnancy. 61
32029819 2020
42
[Acute loss of visual acuity after pregnancy]. 61
31144012 2020
43
The value of the routine third trimester ultrasound scan in antenatal care: Problems with guidance and outdated data in a highly technological field. 61
31851896 2020
44
Placental fibronectin staining is unaffected in pregnancies complicated by late-onset intrauterine growth restriction and small for gestational age fetuses. 61
31743426 2020
45
Is the closest health facility the one used in pregnancy care-seeking? A cross-sectional comparative analysis of self-reported and modelled geographical access to maternal care in Mozambique, India and Pakistan. 61
32013994 2020
46
Impact of low-dose aspirin on adverse perinatal outcome: meta-analysis and meta-regression. 61
31479546 2020
47
Maternal asthma and the risk of hypertensive disorders of pregnancy: a systematic review and meta-analysis of cohort studies. 61
31762345 2020
48
Association of Acculturation With Adverse Pregnancy Outcomes. 61
31923068 2020
49
[External validation of FullPIERS model for prediction of adverse outcomes among women with pre-eclampsia in French maternity of 2014 to 2018]. 61
31923643 2020
50
A more accurate prediction to rule in and rule out pre-eclampsia using the sFlt-1/PlGF ratio and NT-proBNP as biomarkers. 61
31734648 2020

Variations for Eclampsia

Expression for Eclampsia

Search GEO for disease gene expression data for Eclampsia.

Pathways for Eclampsia

Pathways related to Eclampsia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.3 VEGFA PGF FLT1
2 10.55 VEGFA SERPINC1 FLT1
3
Show member pathways
10 VEGFA PGF FLT1

GO Terms for Eclampsia

Cellular components related to Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 VEGFA TAC3 SERPINC1 PGF PAPPA OXT
2 extracellular space GO:0005615 9.36 VEGFA THBD TAC3 SERPINC1 PGF PAPPA

Biological processes related to Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.71 VEGFA PGF FLT1 ENG
2 positive regulation of angiogenesis GO:0045766 9.56 VEGFA PGF FLT1 ENG
3 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.54 VEGFA PGF FLT1
4 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.46 VEGFA FLT1
5 induction of positive chemotaxis GO:0050930 9.43 VEGFA PGF
6 vascular endothelial growth factor signaling pathway GO:0038084 9.33 VEGFA PGF FLT1
7 positive regulation of mast cell chemotaxis GO:0060754 9.32 VEGFA PGF
8 sprouting angiogenesis GO:0002040 9.26 VEGFA PGF FLT1 ENG
9 female pregnancy GO:0007565 9.1 THBD TAC3 PGF PAPPA OXT CORIN

Molecular functions related to Eclampsia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vascular endothelial growth factor receptor binding GO:0005172 8.62 VEGFA PGF

Sources for Eclampsia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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