Ectopic Cushing Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Ectopic Cushing Syndrome

MalaCards integrated aliases for Ectopic Cushing Syndrome:

Name: Ectopic Cushing Syndrome ¹¹ ⁵⁸ ¹⁴

Cushing Syndrome Due to Ectopic Acth Secretion ¹¹ ⁵⁸

Ectopic Acth Secreting Tumor ¹¹ ⁵⁸

Adrenocorticotropic Hormone Secretion Syndrome ⁵⁸

Paraneoplastic Cushing Syndrome ⁵⁸

Occult Ectopic Acth Secretion ⁵⁸

Characteristics:

Age Of Onset:

Cushing Syndrome Due to Ectopic Acth Secretion: Adult,Elderly ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases Reproductive diseases Endocrine diseases

See all MalaCards categories (disease lists)

ICD10: ³¹ ³²

Endocrine, nutritional and metabolic diseases

Disorders of other endocrine glands

Cushing syndrome

Ectopic ACTH syndrome

Orphanet: ⁵⁸

Rare gastroenterological diseases

Rare infertility disorders

Rare endocrine diseases

External Ids:

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Summaries for Ectopic Cushing Syndrome

Orphanet: ⁵⁸ Cushing syndrome due to ectopic (adrenocorticotropic hormone) ACTH secretion (EAS) is a form of ACTH-dependent Cushing syndrome (see this term) caused by excess secretion of ACTH by a benign or, more often, malignant non-pituitary tumor.

MalaCards based summary: Ectopic Cushing Syndrome, also known as cushing syndrome due to ectopic acth secretion, is related to hypokalemia and carcinoid tumors, intestinal. An important gene associated with Ectopic Cushing Syndrome is POMC (Proopiomelanocortin), and among its related pathways/superpathways are G alpha (s) signalling events and Corticotropin-releasing hormone signaling pathway. The drugs Dopamine and Octreotide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, small intestine and prostate, and related phenotypes are diabetes mellitus and increased circulating cortisol level

Disease Ontology: ¹¹ A primary hyperaldosteronism that is characterized by a tumor outside the pituitary gland produces a hormone called adrenocorticotropic hormone.

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Related Diseases for Ectopic Cushing Syndrome

Diseases related to Ectopic Cushing Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 335)

#	Related Disease	Score	Top Affiliating Genes
1	hypokalemia	30.6	POMC NR3C1 CRH
2	carcinoid tumors, intestinal	30.4	SYP SST CHGA
3	bronchial adenomas/carcinoids childhood	30.4	SST POMC
4	premature ovarian failure 7	30.3	POMC CRH
5	thyroid carcinoma, familial medullary	30.3	SST CHGA CALCA
6	zollinger-ellison syndrome	30.3	SST CHGA
7	lung oat cell carcinoma	30.1	SYP POMC CHGA
8	acne	30.1	PRL POMC CRH
9	teratoma	30.1	SYP SST CHGA
10	empty sella syndrome	30.0	PRL POMC
11	neuroendocrine tumor	29.9	SYP SST POMC CHGA CALCA
12	adrenal neuroblastoma	29.9	SYP CHGA
13	carcinoid syndrome	29.8	SYP SST CHGA CALCA
14	pancreatoblastoma	29.8	SYP CHGA
15	mediastinal cancer	29.8	SYP CHGA
16	conn's syndrome	29.7	TBX19 SYP SST PRL POMC NR3C1
17	pituitary-dependent cushing's disease	29.7	SST PRL POMC NR3C1 CRH
18	gastrointestinal neuroendocrine tumor	29.7	SYP SST CHGA
19	adrenal cortical adenoma	29.6	SYP POMC CHGA
20	gastrinoma	29.6	SYP SST POMC CHGA
21	pulmonary neuroendocrine tumor	29.6	SYP SST CHGA
22	large cell neuroendocrine carcinoma	29.6	SYP SST CHGA
23	neuroendocrine carcinoma	29.6	SYP SST CHGA CALCA
24	small cell cancer of the lung	29.5	SYP SST POMC CHGA CALCA
25	islet cell tumor	29.5	SYP SST POMC CHGA CALCA
26	endocrine gland cancer	29.4	SYP SST CHGA
27	mediastinal lipomatosis	29.4	SYP POMC NR3C1 CRH
28	thyroid gland medullary carcinoma	29.2	SYP SST POMC CHGA CALCA
29	nelson syndrome	29.0	TBX19 SST PRL POMC NR3C1 CRH
30	multiple endocrine neoplasia, type i	28.9	SYP SST PRL POMC CHGA
31	pituitary adenoma	28.9	SST PRL POMC NR3C1 CRH CHGA
32	multiple endocrine neoplasia	28.8	SYP SST PRL POMC CHGA CALCA
33	pheochromocytoma	28.5	SYP SST PRL POMC CRH CHGA
34	thyroid carcinoma	10.3
35	colon adenocarcinoma	10.3
36	thymic carcinoma	10.3
37	sacrococcygeal teratoma	10.3
38	hyperpigmentation of the skin	10.3
39	waterhouse-friderichsen syndrome	10.3	POMC CRH
40	functionless pituitary adenoma	10.3	SST POMC
41	paraneoplastic syndromes	10.3
42	somatization disorder	10.3	POMC CRH
43	neurotic disorder	10.2	POMC CRH
44	retrograde amnesia	10.2	POMC CRH
45	adjustment disorder	10.2	POMC CRH
46	adamantinous craniopharyngioma	10.2	TBX19 POMC
47	dysthymic disorder	10.2	POMC CRH
48	pituitary adenoma 4, acth-secreting	10.2
49	pancreatic cancer	10.2
50	hyperuricemia, pulmonary hypertension, renal failure, and alkalosis syndrome	10.2

Graphical network of the top 20 diseases related to Ectopic Cushing Syndrome:

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Symptoms & Phenotypes for Ectopic Cushing Syndrome

Human phenotypes related to Ectopic Cushing Syndrome:

⁵⁸ ³⁰ (show top 50) (show all 84)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	diabetes mellitus ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0000819
2	increased circulating cortisol level ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0003118
3	increased circulating acth level ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0003154
4	paradoxical increased cortisol secretion on dexamethasone suppression test ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0003466
5	increased urinary cortisol level ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0012030
6	fatiguable weakness of proximal limb muscles ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0030200
7	emotional lability ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000712
8	hypertension ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000822
9	immunodeficiency ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002721
10	acne ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001061
11	osteoporosis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000939
12	anxiety ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000739
13	striae distensae ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001065
14	lymphopenia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001888
15	insomnia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0100785
16	bruising susceptibility ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000978
17	truncal obesity ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001956
18	hirsutism ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001007
19	leukocytosis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001974
20	thin skin ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000963
21	adrenal hyperplasia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0008221
22	poor wound healing ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001058
23	hyperpigmentation of the skin ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000953
24	plethora ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001050
25	proximal amyotrophy ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0007126
26	intra-oral hyperpigmentation ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0010284
27	abdominal obesity ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0012743
28	capillary fragility ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0025017
29	dorsocervical fat pad ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0025383
30	asthenia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0025406
31	increased circulating androgen concentration ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0030348
32	ecchymosis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0031364
33	abnormal libido ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0031845
34	decreased eosinophil count ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0031891
35	moon facies ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0500011
36	depression ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000716
37	secondary amenorrhea ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000869
38	myocardial infarction ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001658
39	skin ulcer ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0200042
40	anorexia ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002039
41	sparse scalp hair ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002209
42	stroke ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001297
43	weight loss ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001824
44	memory impairment ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002354
45	diarrhea ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002014
46	neoplasm of the thymus ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0100521
47	peripheral edema ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0012398
48	psychotic episodes ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000725
49	oligomenorrhea ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000876
50	abnormality of the lymph nodes ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002733

MGI Mouse Phenotypes related to Ectopic Cushing Syndrome:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	9.96	CALCA CHGA CRH NR3C1 POMC PRL
2	homeostasis/metabolism	MP:0005376	9.81	CALCA CHGA CRH NR3C1 POMC PRL
3	no phenotypic analysis	MP:0003012	9.72	CHGA CRH NR3C1 POMC SST
4	endocrine/exocrine gland	MP:0005379	9.5	CHGA CRH NR3C1 POMC PRL SSR2
5	integument	MP:0010771	9.17	CALCA CRH NR3C1 POMC PRL SSR2

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Drugs & Therapeutics for Ectopic Cushing Syndrome

Drugs for Ectopic Cushing Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Dopamine

Approved

Phase 2

62-31-7, 51-61-6

681

2

Octreotide

Approved, Investigational

Phase 2

83150-76-9

383414 6400441

3

Dihydroxyphenylalanine

Phase 2

4

Neurotransmitter Agents

Phase 2

5

Dopamine Agents

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Patients With Ectopic Cushing Syndrome	Recruiting	NCT02019706	Phase 2	68Ga-DOTATATE;18F-DOPA

Search NIH Clinical Center for Ectopic Cushing Syndrome

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Genetic Tests for Ectopic Cushing Syndrome

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Anatomical Context for Ectopic Cushing Syndrome

Organs/tissues related to Ectopic Cushing Syndrome:

MalaCards : Pituitary, Small Intestine, Prostate, Thymus, Thyroid, Lung, Skin

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Publications for Ectopic Cushing Syndrome

Articles related to Ectopic Cushing Syndrome:

(show top 50) (show all 118)

#	Title	Authors	PMID	Year
1	Combined large-cell neuroendocrine carcinoma and atypical carcinoid of the thymus presenting as ectopic Cushing syndrome. ⁶²	Maciejewski A...Ruchala M	35930234	2022
2	Abiraterone acetate for treatment of ectopic Cushing syndrome caused by ACTH-producing neuroendocrine tumor: a case report. ⁶²	Chacko R...Loutfi R	36388644	2022
3	Ectopic Cushing's syndrome in a patient with metastatic Merkel cell carcinoma: A case report. ⁶²	Ishay A...Bisharat N	36158508	2022
4	Limited Invasive Protocol: Optimizing Diagnostic Modalities in Corticotropin Mediated Cushing Syndrome. ⁶²	Gupta R...Dhandapani S	35525501	2022
5	Management of adrenocorticotropic hormone-secreting neuroendocrine tumors and the role of bilateral adrenalectomy in ectopic Cushing syndrome. ⁶²	Landry JP...Perrier ND	35437162	2022
6	Successful resolution of ectopic Cushing syndrome by minimally invasive thoracoscopic resection of the neuroendocrine tumor of the thymus: a rare case report. ⁶²	Zhou Z...Roessner ED	35690804	2022
7	Rare case of renal Ewing sarcoma presenting as ectopic Cushing syndrome in a 12-year-old girl. ⁶²	Karguppikar MB...Khadilkar A	35131789	2022
8	Acute elevation of interleukin 6 and matrix metalloproteinase 9 during the onset of pituitary apoplexy in Cushing's disease. ⁶²	Araki T...Kawakami Y	34041660	2021
9	Medullary thyroid carcinoma with diabetic ketoacidosis: an autopsy case report and literature review. ⁶²	Cheong H...Koo HL	34383239	2021
10	Neuroendocrine neoplasia and bone (Review). ⁶²	Ghemigian A...Valea A	34584564	2021
11	Median 10 years follow-up of patients with covert Cushing's syndrome: a case series. ⁶²	Najafipour F...Sadra V	34635153	2021
12	Paraneoplastic Cushing Syndrome in Gastrointestinal Neuroendocrine Tumour. ⁶²	Mineur L...Vazquez L	34720949	2021
13	[Current role of bilateral adrenalectomy in Ectopic Cushing syndrome.] ⁶²	Garcia-Marchinena P...Cavadas D	34219061	2021
14	The value of [68Ga]Ga-DOTA-TATE PET/CT in diagnosis and management of suspected pituitary tumors. ⁶²	Novruzov F...Kayani I	34181114	2021
15	Usefulness of imaging modalities in providing timely optimal treatment in atypical clinical course of ectopic Cushing syndrome caused by phreochromocytoma. ⁶²	Kurzynska A...Przybylik-Mazurek E	33720642	2021
16	Ectopic Cushing syndrome in Colombia. ⁶²	Lopez-Montoya V...Jimenez C	34033277	2021
17	Ectopic Cushing Syndrome in Adenocarcinoma of the Lung: Case Report and Literature Review. ⁶²	Al-Zakhari R...Otterbeck P	34079679	2021
18	Somatostatin receptor PET beyond the neuroendocrine tumors of the gastrointestinal tract - the review of literature. ⁶²	Zogala D	34905930	2021
19	Case Report: A Challenging Localization of a Pulmonary Ectopic ACTH-Secreting Tumor in a Patient With Severe Cushing's Syndrome. ⁶²	Serban AL...Arosio M	34305814	2021
20	To determine the efficacy of bilateral inferior petrosal sinus sampling in differentiating Cushing disease from ectopic Cushing syndrome. ⁶²	Azeemuddin M...Khan R	33484548	2021
21	Use of 18F-FDG PET/CT to Differentiate Ectopic Adrenocorticotropic Hormone-Secreting Lung Tumors From Tumor-Like Pulmonary Infections in Patients With Ectopic Cushing Syndrome. ⁶²	Hou G...Cheng X	34692551	2021
22	Diagnosis and management of small pulmonary atypical carcinoid tumor associated with Cushing syndrome. ⁶²	Benissan-Messan DZ...Kneuertz PJ	33318759	2020
23	Ectopic Cushing syndrome caused by a pancreatic neuroendocrine tumor: A case report. ⁶²	Shayesteh S...Kawamoto S	32547669	2020
24	Functional imaging in ectopic Cushing syndrome. ⁶²	Grigoryan S...Turcu AF	32250975	2020
25	Ectopic Cushing Syndrome: A Rare Cause of Electrolyte Derangements. ⁶²	Fanous N...Casella JL	31606493	2020
26	A case of gastrinoma associated with ectopic Cushing syndrome. ⁶²	Kubicka E...Bolanowski M	32077445	2020
27	Ectopic Corticotropin-Releasing Hormone-Secreting Pancreatic Neuroendocrine Tumor: Excellent Response of Liver Metastases to Peptide Receptor Radionuclide Therapy as Demonstrated by 68Ga-DOTATOC and 18F-FDG PET/CT Imaging. ⁶²	Zhang J...Baum RP	31714276	2020
28	Ectopic ACTH syndrome of different origin-Diagnostic approach and clinical outcome. Experience of one Clinical Centre. ⁶²	Palen-Tytko JE...Hubalewska-Dydejczyk AB	33237923	2020
29	68Ga-DOTATATE PET/CT of Ectopic Cushing Syndrome Due to Appendicular Carcinoid. ⁶²	Diwaker C...Shah N	31524683	2019
30	ACTH-producing tumorlets and carcinoids of the lung: clinico-pathologic study of 63 cases and review of the literature. ⁶²	La Rosa S...Imperatori A	31264037	2019
31	Illicit Upregulation of Serotonin Signaling Pathway in Adrenals of Patients With High Plasma or Intra-Adrenal ACTH Levels. ⁶²	Le Mestre J...Louiset E	31074783	2019
32	Acute Liver Failure Due to Severe Hepatic Metastasis of Small-cell Lung Cancer Producing Adrenocorticotropic Hormone Complicating Ectopic Cushing Syndrome. ⁶²	Kamijo S...Nagata K	31243230	2019
33	Fluconazole treatment in severe ectopic Cushing syndrome ⁶²	Canteros TM...Fainstein-Day P	31373475	2019
34	Ectopic ACTH Syndrome With Association of Multiple Pulmonary Sclerosing Pneumocytomas and Multiple Carcinoid Tumorlets. ⁶²	Benito-Martinez E...Pasquel FJ	31020057	2019
35	Sporadic Medullary Thyroid Carcinoma with Paraneoplastic Cushing Syndrome. ⁶²	Pivovarova AI...Reddy PJ	31885947	2019
36	Severe Hypercortisolism with Hypokalemic Alkalosis Mimicking Ectopic Cushing Syndrome in a Patient with Cushing Disease Due to Pituitary Microadenoma. ⁶²	Goyal A...Khadgawat R	30766837	2018
37	Two types of ectopic Cushing syndrome or a continuum? Review. ⁶²	Araujo Castro M...Marazuela Azpiroz M	29766359	2018
38	Ectopic Cushing Syndrome (ECS): 68Ga-DOTANOC PET/CT Localizes the Site of Ectopic Adrenocorticotropic Hormone Production. ⁶²	Parihar AS...Bhansali A	30036246	2018
39	THYMIC CARCINOID WITH ADRENOCORTICOTROPIC HORMONE-PRODUCING ECTOPIC CUSHING SYNDROME AND EMPTY SELLA. ⁶²	Labadzhyan A...Melmed S	31897433	2018
40	Paraneoplastic Cushing syndrome, case-series and review of the literature. ⁶²	Deldycke A...Taes Y	28895465	2018
41	Ectopic Cushing syndrome: Report of 9 cases. ⁶²	Araujo Castro M...Estrada Garcia J	29655957	2018
42	Combined Ovarian and Adrenal Venous Sampling in the Localization of Adrenocorticotropic Hormone-Independent Ectopic Cushing Syndrome. ⁶²	Chen S...Zhu H	29161416	2018
43	Case report: Ectopic Cushing's syndrome in a young male with hidden lung carcinoid tumor. ⁶²	Aljassem G...Aljasem H	29202350	2018
44	Case-series of paraneoplastic Cushing syndrome in small-cell lung cancer. ⁶²	Richa CG...Merheb MT	29535866	2018
45	Psychosis as a sequelae of paraneoplastic syndrome in Small- Cell Lung Carcinoma: A psycho-neuroendocrine interface. ⁶²	Wilkins CM...Birur B	29164929	2017
46	ECTOPIC CUSHING SYNDROME: A 10-YEAR EXPERIENCE FROM A TERTIARY CARE CENTER IN SOUTHERN INDIA. ⁶²	Sathyakumar S...Thomas N	28614007	2017
47	Paraneoplastic Cushing Syndrome Due To Wilm's Tumor. ⁶²	Faizan M...Ali AS	28599697	2017
48	Successful percutaneous CT-guided microwave ablation of adrenal gland for ectopic Cushing syndrome. ⁶²	Zener R...Mujoomdar A	27919009	2017
49	Ectopic Cushing syndrome in small cell lung cancer: A case report and literature review. ⁶²	Zhang HY...Zhao J	28102935	2017
50	A Case of Paraneoplastic Cushing Syndrome Presenting as Hyperglycemic Hyperosmolar Nonketotic Syndrome. ⁶²	Brzezniak CE...Carter CA	28512417	2017

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Genes for Ectopic Cushing Syndrome

Genes related to Ectopic Cushing Syndrome (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	POMC	Proopiomelanocortin	Protein Coding	8.11	DISEASES inferred ¹⁴
2	CRH	Corticotropin Releasing Hormone	Protein Coding	7.05	DISEASES inferred ¹⁴
3	SST	Somatostatin	Protein Coding	5.98	DISEASES inferred ¹⁴
4	TBX19	T-Box Transcription Factor 19	Protein Coding	5.87	DISEASES inferred ¹⁴
5	SSR2	Signal Sequence Receptor Subunit 2	Protein Coding	5.52	DISEASES inferred ¹⁴
6	CHGA	Chromogranin A	Protein Coding	5.38	DISEASES inferred ¹⁴
7	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	5.21	DISEASES inferred ¹⁴
8	PRL	Prolactin	Protein Coding	5.17	DISEASES inferred ¹⁴
9	SYP	Synaptophysin	Protein Coding	4.92	DISEASES inferred ¹⁴
10	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	4.92	DISEASES inferred ¹⁴

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Variations for Ectopic Cushing Syndrome

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Expression for Ectopic Cushing Syndrome

Search GEO for disease gene expression data for Ectopic Cushing Syndrome.

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Pathways for Ectopic Cushing Syndrome

Pathways related to Ectopic Cushing Syndrome according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	G alpha (s) signalling events ⁶⁶ Show member pathways Defective ACTH causes obesity and POMCD ⁶⁶	11.64	POMC CRH CALCA
2	Corticotropin-releasing hormone signaling pathway ⁷⁴	11.29	TBX19 POMC CRH
3	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.09	NR3C1 CALCA
4	Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4) ⁷⁴	10.91	PRL NR3C1
5	Serotonin and anxiety ⁷⁴ Show member pathways Serotonin and anxiety-related events ⁷⁴	10.83	POMC CRH
6	Glucocorticoid receptor regulatory network ⁶¹	10.69	PRL POMC NR3C1
7	Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics ⁶⁰	10.62	PRL POMC
8	Glucocorticoid Pathway (HPA Axis), Pharmacodynamics ⁶⁰	9.8	POMC CRH

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GO Terms for Ectopic Cushing Syndrome

Cellular components related to Ectopic Cushing Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	neuronal dense core vesicle	GO:0098992	8.92	SST CHGA CALCA

Biological processes related to Ectopic Cushing Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of blood pressure	GO:0008217	9.02	POMC CHGA CALCA

Molecular functions related to Ectopic Cushing Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	9.32	SST PRL POMC CRH CALCA

Sources

Sources for Ectopic Cushing Syndrome

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ECT093 MIFTS: 45	Ectopic Cushing Syndrome Categories: Endocrine diseases, Gastrointestinal diseases, Rare diseases, Reproductive diseases	Data Licensing For inquiries, contact: [email protected]
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