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MCID: ECT026
MIFTS: 48

Ectopic Pregnancy

Categories: Fetal diseases, Rare diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Ectopic Pregnancy

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MalaCards integrated aliases for Ectopic Pregnancy:

Name: Ectopic Pregnancy 12 74 20 42 15 71 32
Ectopic Pregnancies 15
Pregnancy, Ectopic 44
Pregnancy Ectopic 54
Eccyesis 12

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:0060329
ICD9CM 34 633
MeSH 44 D011271
NCIt 50 C34945
SNOMED-CT 67 156080003
ICD10 32 O00 O00.9
UMLS 71 C0032987
Sources

Summaries for Ectopic Pregnancy

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MedlinePlus : 42 The uterus, or womb, is the place where a baby grows when a woman is pregnant. If you have an ectopic pregnancy, the fertilized egg grows in the wrong place, outside the uterus, usually in the fallopian tubes. The result is usually a miscarriage. Ectopic pregnancy can be a medical emergency if it ruptures. Signs of ectopic pregnancy include Abdominal pain Shoulder pain Vaginal bleeding Feeling dizzy or faint Get medical care right away if you have these signs. Doctors use drugs or surgery to remove the ectopic tissue so it doesn't damage your organs. Many women who have had ectopic pregnancies go on to have healthy pregnancies later. Dept. of Health and Human Services Office on Women's Health

MalaCards based summary : Ectopic Pregnancy, also known as ectopic pregnancies, is related to gestational trophoblastic neoplasm and choriocarcinoma, and has symptoms including pelvic pain and morning sickness. An important gene associated with Ectopic Pregnancy is CGB3 (Chorionic Gonadotropin Subunit Beta 3), and among its related pathways/superpathways are Interleukin-4 and 13 signaling and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. The drugs Methotrexate and Letrozole have been mentioned in the context of this disorder. Affiliated tissues include uterus, ovary and endothelial, and related phenotype is integument.

Disease Ontology : 12 A female reproductive system disease characterized by the implantation of the embryo outside the uterine cavity.

Wikipedia : 74 Ectopic pregnancy is a complication of pregnancy in which the embryo attaches outside the uterus. Signs... more...

Sources

Related Diseases for Ectopic Pregnancy

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Diseases related to Ectopic Pregnancy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 299)
# Related Disease Score Top Affiliating Genes
1 gestational trophoblastic neoplasm 31.7 PGF PAPPA LGALS1 CGB5 CGB3
2 choriocarcinoma 31.1 LIF CGB7 CGB5 CGB3 CGA
3 hydatidiform mole, recurrent, 1 31.1 CGB5 CGB3 CGA
4 endometriosis 31.0 VEGFA PAEP LIF IL1B GNRH1
5 ovarian cyst 31.0 VEGFA PAEP GNRH1
6 corpus luteum cyst 30.9 GNRH1 CGB5
7 ovarian hyperstimulation syndrome 30.8 VEGFA GNRH1 CGB5 CGA
8 teratoma 30.7 CGB7 CGB5 CGB3 CGA
9 trophoblastic neoplasm 30.7 LGALS1 CGB5 CGB3 CGA
10 adenomyosis 30.6 VEGFA LIF GNRH1
11 placenta praevia 30.5 PGF PAPPA
12 triploidy 30.4 PAPPA CGB7 CGA
13 placenta accreta 30.4 VEGFA PGF PAPPA
14 chromosomal triplication 30.3 PAPPA CGB7 CGB3
15 exanthem 30.3 VEGFA PIK3C2A IL1B
16 placental site trophoblastic tumor 30.3 VEGFA LGALS1 CGB5 CGB3
17 eclampsia 30.3 VEGFA PGF PAPPA
18 placenta disease 30.0 VEGFA PGF PAPPA LGALS1 IL1B CGB7
19 epithelioid trophoblastic tumor 30.0 MUC1 LGALS1 CGB3
20 oligohydramnios 30.0 PGF PAPPA CGA
21 endometrial adenocarcinoma 30.0 VEGFA PAEP MUC1
22 adenomyoma 29.8 MUC1 GNRH1
23 pre-eclampsia 29.6 VEGFA PGF PAPPA IL1B FST CGB7
24 down syndrome 29.6 PGF PAPPA CGB7 CGB5 CGB3 CGA
25 pelvic inflammatory disease 11.3
26 chlamydia 11.2
27 diethylstilbestrol syndrome 11.2
28 hydatidiform mole, recurrent, 2 11.1
29 infertility 10.7
30 amenorrhea 10.7
31 salpingitis 10.6
32 appendicitis 10.5
33 mixed germ cell tumor 10.5 CGB3 CGA
34 sacrococcygeal teratoma 10.5 CGB7 CGA
35 nonseminomatous germ cell tumor 10.4 CGB7 CGB5
36 mixed ductal-endocrine carcinoma 10.4 CGB7 CGB3
37 patellofemoral pain syndrome 10.4 CGB7 CGB3
38 anorchia 10.4 CGB5 CGA
39 localized pulmonary fibrosis 10.4 MUC1 IL1B
40 penis agenesis 10.4 GNRH1 CGA
41 germinoma 10.4 CGB5 CGB3 CGA
42 trisomy 22 10.4 PAPPA CGB7
43 infiltrating angiolipoma 10.4 VEGFA GNRH1
44 ulcer of lower limbs 10.4 VEGFA IL1B
45 oocyte maturation defect 1 10.4 FST CGA
46 mucinous cystadenofibroma 10.4 PAEP MUC1
47 glomeruloid hemangioma 10.3 VEGFA IL1B
48 gynecomastia 10.3 GNRH1 CGB5 CGA
49 cancer-associated retinopathy 10.3 VEGFA PGF
50 submucous uterine fibroid 10.3 PAEP LIF

Graphical network of the top 20 diseases related to Ectopic Pregnancy:



Diseases related to Ectopic Pregnancy
Sources

Symptoms & Phenotypes for Ectopic Pregnancy

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UMLS symptoms related to Ectopic Pregnancy:


pelvic pain, morning sickness

MGI Mouse Phenotypes related to Ectopic Pregnancy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.28 FST GNRH1 IL1B LGALS1 LIF MYH11
Sources

Drugs & Therapeutics for Ectopic Pregnancy

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Drugs for Ectopic Pregnancy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
2
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
3 Hormone Antagonists Phase 3
4 Hormones Phase 3
5 Aromatase Inhibitors Phase 3
6 Estrogen Antagonists Phase 3
7 Estrogens Phase 3
8 Estrogen Receptor Antagonists Phase 3
9
Levoleucovorin Approved, Investigational Phase 1, Phase 2 68538-85-2 149436
10
Folic acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
11 Immunosuppressive Agents Phase 1, Phase 2
12 Folic Acid Antagonists Phase 1, Phase 2
13 Immunologic Factors Phase 1, Phase 2
14 Vitamin B Complex Phase 1, Phase 2
15 Antimetabolites Phase 1, Phase 2
16 Folate Phase 1, Phase 2
17 Dermatologic Agents Phase 1, Phase 2
18 Antirheumatic Agents Phase 1, Phase 2
19 Vitamin B9 Phase 1, Phase 2
20 Anesthetics Phase 1, Phase 2
21
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
22
Progesterone Approved, Vet_approved 57-83-0 5994
23
Polyestradiol phosphate Approved 28014-46-2
24
Aspirin Approved, Vet_approved 50-78-2 2244
25
Menotropins Approved 9002-68-0, 61489-71-2 5360545
26
Ganirelix Approved 124904-93-4, 123246-29-7 25081094
27
Sodium citrate Approved, Investigational 68-04-2
28
Cetrorelix Approved, Investigational 120287-85-6 16129715 25074887
29
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
30
Creatine Approved, Investigational, Nutraceutical 57-00-1 586
31
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
32
Imidacloprid Vet_approved 105827-78-9 86418
33
Enclomiphene Investigational 15690-57-0
34 Vitamins
35 Calcium, Dietary
36 Calciferol
37 Estradiol 17 beta-cypionate
38 Estradiol 3-benzoate
39 Mitogens
40 Endothelial Growth Factors
41 Pharmaceutical Solutions
42 Arginine Vasopressin
43 Vasopressins
44 Anti-Inflammatory Agents
45 Analgesics, Non-Narcotic
46 Fibrinolytic Agents
47 Cyclooxygenase Inhibitors
48 Anti-Inflammatory Agents, Non-Steroidal
49 Analgesics
50 Platelet Aggregation Inhibitors

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 A RANDOMISED TRIAL COMPARING LAPARASCOPY VERSUS LAPAROTOMY IN THE MANAGEMENT OF WOMEN DIAGNOSED WITH ECTOPIC PREGNANCY Unknown status NCT01932957 Phase 4
2 BHCG Level in Day 4,7, in Comparison to Day 10 as an Indicator for Treatment Success Unknown status NCT01860690 Phase 4 Methotrexate
3 Effectiveness Of Expectant Management In The Tubal Ectopic Pregnancy Completed NCT01876004 Phase 4 Methotrexate;Placebo
4 Comparison of Single and Multiple-dose Methotrexate Therapy for Ectopic Pregnancy: a Clinical Trail Completed NCT01662167 Phase 4 Single;Multipe
5 Comparison of Two-dose and Single-dose Methotrexate Protocol for Ectopic Pregnancy: a Randomized Controlled Trial Completed NCT01855568 Phase 3
6 Two-Dose Methotrexate for Ectopic Pregnancy Completed NCT00194272 Phase 3 Methotrexate
7 Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location - a Randomized Clinical Trial of Women at Risk for an Ectopic Pregnancy: Active Treatment Versus No Treatment Completed NCT02152696 Phase 3 Methotrexate
8 Randomized Controlled Trial on Use of Letrozole in the Medical Management of Tubal Ectopic Pregnancies Not yet recruiting NCT04341545 Phase 3 Letrozole tablets
9 Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location -- a Randomized Clinical Trial of Women at Risk for an Ectopic Pregnancy Terminated NCT01800162 Phase 1, Phase 2 Methotrexate
10 A Randomized, Double-Blind, Placebo Controlled Phase I Study of an Amino Acid For the Reduction of Peritoneal Adhesions in Adult Females Undergoing a Laparoscopic Salpingostomy for the Removal of an Ectopic Pregnancy Unknown status NCT01701193 Phase 1 Amino Acid;Saline
11 Adnexal Mass After Methotrexate Treatment for Ectopic Pregnancies Unknown status NCT03138694
12 The Correlation Between Uterine Endometrial Pattern and Ectopic Pregnancy Unknown status NCT02963012
13 Safety and Effectiveness of Transvaginal Resection of Pregnancy Tissue in the Treatment of Caesarean Scar Pregnancy Unknown status NCT01916746
14 The Impact of Salpingectomy and Single Dose Systemic Methotrexate Treatments on Ovarian Reserve in Ectopic Pregnancy Completed NCT02714998 Methotrexate
15 Serum Bank for Assessment of Markers of Ectopic Pregnancy Completed NCT00194168
16 Can Kisspeptin be Used for Differential Diagnosis of Early Pregnancies? Completed NCT04371991
17 eDiagEPU, a Computerized Help to Diagnosis for Early Pregnancy Unit : a Retrospective Study Completed NCT03993015
18 Single Determination of Serum Activin A and Inhibin A in Predicting the Outcome of Pregnancies of Unknown Location (PUL) After IVF and Oocyte Donation. Completed NCT01589016
19 The Effect of Serum Vitamin D and Calcium Levels in Ectopic Pregnancies Completed NCT03894735
20 Retrospective Cohort Study of Increased Risk of Ectopic Pregnancy Associated With Marked Variation of Estradiol During the Early Luteal Phase and High Progesterone on hCG Day in IVF Completed NCT02793089
21 Cornual Wedge Resection for Interstitial Pregnancy and Postoperative Outcome Completed NCT03974841
22 Sonographic Assessment and Visualization of Ectopics in Emergency Medicine (SAVE'EM) Completed NCT01322958
23 Are Serum Levels of Vascular Endothelial Growth Factor a Marker for the Early Diagnosis of Ectopic Pregnancy? Completed NCT01261026
24 Risk Factors for Ectopic Pregnancy: Comparison of Fresh and Warmed Transfers. Analysis of a 10 Years, a Single Center Experience. Completed NCT04325854
25 Risk Factors as Predictors of Ectopic PRegnancy Completed NCT00194207
26 Clinical Outcome of Laparoscopic Tubal Preservation Surgery for Ectopic Pregnancy Completed NCT03253588
27 Vascular Endothelial Growth Factor Levels in Ectopic Pregnancy Completed NCT01601964
28 Evaluation of the Axonemal Dynein Heavy Chain 5 and Creatine Kinase Concentration in Cervical Fluid for Early Detection of the Ectopic Pregnancy Completed NCT02995356
29 Pregnancies of Uncertain Location or Viability Research Completed NCT02700789
30 The Significance of Low-Dose Aspirin on Ovarian Responsiveness, Uterine Hemodynamics and Pregnancy Outcome in in Vitro Fertilization and in Intracytoplasmic Sperm Injection: A Randomized, Placebo-Controlled Double-Blind Study Completed NCT00683202 Acetylsalicylic acid;Placebo
31 Populationbased Screening for Urogenital Chlamydia Trachomatis Infections by Use of Home-Obtained and Mailed Samples: A Randomized Study Completed NCT00827970
32 Serum Vascular Endothelial Growth Factor (VEGF) As a Marker for Tubal Pregnancy Completed NCT02973230
33 Comparison of Conventional Laparoscopy and Natural Orifice Transluminal Endoscopic Surgery in the Surgical Treatment of Tubal Ectopic Pregnancy Recruiting NCT04315779
34 - a Randomized Control Trial of Two hCG- Based Decision Support Models Recruiting NCT03461835
35 Clinical Application of Laparo-endoscopic Single-site Surgery and Natural Orifice Transluminal Endoscopic in Gynecology- the Chinese National Registry Recruiting NCT04096872
36 Assessment of Biomarkers in Pregnancy on Unknown Location and Ectopic Pregnancy Recruiting NCT04738370
37 Medication Abortion for Pregnancy of Unknown Location Recruiting NCT04026789
38 Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Women With Infertility Problems Recruiting NCT04071574 Human Chorionic Gonadotropin (hCG);Gonadotropins;GNRH-A Triptorelin;GnRH antagonist
39 Psychological Impact of Pregnancy of Unknown Location Recruiting NCT04739956
40 A Pilot Study to Test Rapid Acquisition of Point of Care Ultrasound for Various Applications Recruiting NCT02831556
41 Point-of-care Ultrasound in Finland Recruiting NCT03327688
42 Incidence and Trend of Ectopic Pregnancy 2009-2018 - A Population-based Study Active, not recruiting NCT03670784
43 The Comparison of Reproductive Outcomes of Hsyteroscopic Metroplasty Versus Spontaneous Coitus Plus COH/IUI Cycles in Unexplained Infertile Women With Dysmorphic Uterus Enrolling by invitation NCT03579550
44 The Aromatase Inhibitor and Gnrh Antagonist Versus Methotrexate for Management of Undisturbed Ectopic Pregnancy Not yet recruiting NCT04308343 Methotrexate;Letrozole;cetrotide
45 Pragmatic Evaluation of Ultra-portable Ultrasound for a List of Indications in General Practice Not yet recruiting NCT04127149
46 The Assessment of Biomarkers in Ectopic Pregnancy Suspended NCT04176549

Search NIH Clinical Center for Ectopic Pregnancy

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Mifepristone

Cochrane evidence based reviews: pregnancy, ectopic

Sources

Genetic Tests for Ectopic Pregnancy

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Sources

Anatomical Context for Ectopic Pregnancy

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MalaCards organs/tissues related to Ectopic Pregnancy:

40
Uterus, Ovary, Endothelial, Placenta, Cervix, Liver, Pituitary
Sources

Publications for Ectopic Pregnancy

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Articles related to Ectopic Pregnancy:

(show top 50) (show all 9004)
# Title Authors PMID Year
1
Thresholds for managing live caesarean scar ectopics expectantly - where should we draw the line? 42
33373050 2020
2
Tubal infertility and pelvic adhesion increase risk of heterotopic pregnancy after in vitro fertilization: A retrospective study. 42
33181716 2020
3
A comparison between laparoscopy and hysteroscopy approach in treatment of cesarean scar pregnancy. 42
33120815 2020
4
Are early human chorionic gonadotropin levels after methotrexate therapy a predictor of response in ectopic pregnancy? 54 61
20510964 2010
5
Human chorionic gonadotropin ratio of hemoperitoneum versus venous serum improves early diagnosis of ectopic pregnancy. 61 54
19046581 2010
6
Methotrexate treatment for ectopic pregnancy at the KK Women's and Children's Hospital, Singapore. 54 61
19960159 2009
7
Relevance of declines in serum human chorionic gonadotropin levels to the management of persistent ectopic pregnancy. 61 54
20149048 2009
8
The use of serum inhibin A and activin A levels in predicting the outcome of 'pregnancies of unknown location'. 61 54
19549702 2009
9
Laparoscopic treatment of early retroperitoneal abdominal pregnancy implanted on inferior vena cava. 54 61
19692871 2009
10
Human chorionic gonadotropin attracts regulatory T cells into the fetal-maternal interface during early human pregnancy. 54 61
19380797 2009
11
Intramural pregnancy associated with adenomyosis after in vitro fertilization and embryo transfer: a case report. 61 54
19438169 2009
12
Human choriogonadotrophin protein core and sugar branches heterogeneity: basic and clinical insights. 54 61
18945715 2009
13
Ectopic pregnancy in adolescents. 61 54
18797271 2008
14
The use of serial human chorionic gonadotropin levels to establish a viable or a nonviable pregnancy. 54 61
18825606 2008
15
The METEX study: methotrexate versus expectant management in women with ectopic pregnancy: a randomised controlled trial. 54 61
18565217 2008
16
[Interstitial pregnancy: a rare type of ectopic pregnancy]. 61 54
18491819 2008
17
Leukemia inhibitory factor (LIF) is immunohistochemically localized in tubal ectopic pregnancy. 61 54
18258286 2008
18
Spontaneous bilateral tubal pregnancies: a case report. 61 54
18198068 2008
19
Comparison of the effect of single-dose and multiple-dose methotrexate therapy on tubal patency. 54 61
17418839 2007
20
Deoxyribonucleic acid of Chlamydia trachomatis in fresh tissue from the Fallopian tubes of patients with ectopic pregnancy. 61 54
17280761 2007
21
Prognostic value of human chorionic gonadotropin changes after methotrexate injection for ectopic pregnancy. 54 61
17418833 2007
22
Rupture of ectopic pregnancy with minimally detectable beta-human chorionic gonadotropin levels: a report of 2 cases. 54 61
17694977 2007
23
Establishing a human chorionic gonadotropin cutoff to guide methotrexate treatment of ectopic pregnancy: a systematic review. 61 54
17173905 2007
24
Human chorionic gonadotropin profile for women with ectopic pregnancy. 61 54
16507931 2006
25
The practical application of a mathematical model to predict the outcome of pregnancies of unknown location. 61 54
16456845 2006
26
Suspected ectopic pregnancy. 61 54
16449130 2006
27
Creatine phosphokinase in ectopic pregnancy revisited: significant diagnostic value of its MB and MM isoenzyme fractions. 61 54
16389014 2006
28
Ectopic pregnancy in a caesarean scar: a case report. 54 61
16524528 2005
29
Diagnostic accuracy of varying discriminatory zones for the prediction of ectopic pregnancy in women with a pregnancy of unknown location. 54 61
16308901 2005
30
Expression of beta-subunit of HCG genes during normal and failed pregnancy. 54 61
16123088 2005
31
The value of a single combined measurement of VEGF, glycodelin, progesterone, PAPP-A, HPL and LIF for differentiating between ectopic and abnormal intrauterine pregnancy. 61 54
16055453 2005
32
Evaluation of the relationship between endometrial thickness and failure of single-dose methotrexate in ectopic pregnancy. 54 61
16001188 2005
33
Presence of a yolk sac on transvaginal sonography is the most reliable predictor of single-dose methotrexate treatment failure in ectopic pregnancy. 61 54
15840789 2005
34
Risk factors associated with the rupture of tubal ectopic pregnancy. 54 61
16141721 2005
35
Pre- and post-treatment patterns of human chorionic gonadotropin for early detection of persistence after a single dose of methotrexate for ectopic pregnancy. 54 61
15474251 2004
36
Ectopic pregnancy: a review. 61 54
15322388 2004
37
Symptomatic patients with an early viable intrauterine pregnancy: HCG curves redefined. 61 54
15229000 2004
38
Leukemia inhibitory factor and homeobox a10 gene expression in an ectopic pregnancy model for implantation. 54 61
15167855 2004
39
[Conservative treatment of ectopic pregnancy in a 27 years old patient with stage-Ia ovarian cancer after conservative surgical treatment and chemotherapy]. 54 61
15738608 2004
40
Human chorionic gonadotropin isoforms in the diagnosis of ectopic pregnancy. 54 61
14633876 2003
41
Implantation-dependent expression of trophinin by maternal fallopian tube epithelia during tubal pregnancies: possible role of human chorionic gonadotrophin on ectopic pregnancy. 54 61
14633596 2003
42
[Management of non-surgical treatment of ectopic pregnancy]. 54 61
14699320 2003
43
Glycodelin serum levels in women with ectopic pregnancy. 54 61
12781411 2003
44
Early and late half-life of human chorionic gonadotropin as a predictor of persistent trophoblast after laparoscopic conservative surgery for tubal pregnancy. 61 54
12780426 2003
45
Heterophile antibody blocking agent to confirm false positive serum human chorionic gonadotropin assay. 61 54
12738132 2003
46
Human chorionic gonadotropin level as a predictor of trophoblastic infiltration into the tubal wall in ectopic pregnancy: a blinded study. 61 54
12749441 2003
47
Persistent ectopic pregnancy after linear salpingotomy: a non-predictable complication to conservative surgery for tubal gestation. 61 54
12421174 2002
48
Presumed diagnosis of ectopic pregnancy. 61 54
12220770 2002
49
Symptom-free women at increased risk of ectopic pregnancy: should we screen? 54 61
12190842 2002
50
Human chorionic gonadotropin patterns after a single dose of methotrexate for ectopic pregnancy. 61 54
11750970 2002
Sources

Variations for Ectopic Pregnancy

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Expression for Ectopic Pregnancy

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Search GEO for disease gene expression data for Ectopic Pregnancy.
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GO Terms for Ectopic Pregnancy

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Cellular components related to Ectopic Pregnancy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 VEGFA PGF PAPPA PAEP MUC1 LIF
2 extracellular region GO:0005576 9.53 VEGFA PROK1 PGF PAPPA PAEP MUC1

Biological processes related to Ectopic Pregnancy according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.11 VEGFA PROKR2 PGF IL1B GNRH1 CGB7
2 G protein-coupled receptor signaling pathway GO:0007186 10.07 PROKR2 PROK1 GNRH1 CGB7 CGB5 CGB3
3 apoptotic process GO:0006915 9.95 PAEP LGALS1 IL1B CGB7 CGB5 CGB3
4 cytokine-mediated signaling pathway GO:0019221 9.86 VEGFA MUC1 LIF IL1B
5 positive regulation of cell proliferation GO:0008284 9.8 VEGFA PROK1 PGF LIF IL1B CGA
6 positive regulation of angiogenesis GO:0045766 9.71 VEGFA PGF IL1B ADAM12
7 hormone-mediated signaling pathway GO:0009755 9.61 CGB7 CGB5 CGB3
8 vascular endothelial growth factor signaling pathway GO:0038084 9.57 VEGFA PGF
9 induction of positive chemotaxis GO:0050930 9.55 VEGFA PGF
10 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.54 PAEP IL1B
11 embryo implantation GO:0007566 9.54 TRO LIF IL1B
12 cardiac muscle fiber development GO:0048739 9.51 VEGFA MYH11
13 positive regulation of mast cell chemotaxis GO:0060754 9.49 VEGFA PGF
14 female gamete generation GO:0007292 9.43 CGB7 CGB5 CGB3
15 peptide hormone processing GO:0016486 9.33 CGB5 CGB3 CGA
16 positive regulation of cell division GO:0051781 9.26 VEGFA PROK1 PGF IL1B
17 cell-cell signaling GO:0007267 9.1 PGF IL1B GNRH1 CGB7 CGB5 CGB3

Molecular functions related to Ectopic Pregnancy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 VEGFA PROK1 PGF LIF
2 vascular endothelial growth factor receptor binding GO:0005172 9.16 VEGFA PGF
3 hormone activity GO:0005179 9.02 GNRH1 CGB7 CGB5 CGB3 CGA
Sources

Sources for Ectopic Pregnancy

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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