Ectopic Pregnancy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ECT026 MIFTS: 46	Ectopic Pregnancy Categories: Fetal diseases, Rare diseases, Reproductive diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Ectopic Pregnancy

MalaCards integrated aliases for Ectopic Pregnancy:

Name: Ectopic Pregnancy ¹¹ ¹⁹ ⁷⁵ ⁴¹ ¹⁴ ⁷¹ ³¹ ³³

Extrauterine Gestation or Pregnancy ³³

Ruptured Ectopic Pregnancy ³³

Aborted Ectopic Pregnancy ³³

Ep - [ectopic Pregnancy] ³³

Extrauterine Pregnancy ³³

Ectopic Pregnancies ¹⁴

Pregnancy, Ectopic ⁴³

Pregnancy Ectopic ⁵³

Ectopic Mole ³³

Eccyesis ¹¹

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Pregnancy, childbirth and the puerperium

Pregnancy with abortive outcome

Ectopic pregnancy

Ectopic pregnancy, unspecified

ICD11: ³³

Pregnancy, childbirth or the puerperium

Abortive outcome of pregnancy

Ectopic pregnancy

Ectopic pregnancy, unspecified

Other specified ectopic pregnancy

External Ids:

Disease Ontology ¹¹ DOID:0060329

ICD9CM ³⁴ 633

MeSH ⁴³ D011271

NCIt ⁴⁹ C34945

SNOMED-CT ⁶⁸ 156080003

ICD10 ³¹ O00 O00.9

ICD11 ³³ 1563334645 1563334645/other 1563334645/unspecified

UMLS ⁷¹ C0032987

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Summaries for Ectopic Pregnancy

MedlinePlus: ⁴¹ The uterus, or womb, is the place where a baby grows when a woman is pregnant. If you have an ectopic pregnancy, the fertilized egg grows in the wrong place, outside the uterus, usually in the fallopian tubes. The result is usually a miscarriage. Ectopic pregnancy can be a medical emergency if it ruptures. Signs of ectopic pregnancy include: Abdominal pain Shoulder pain Vaginal bleeding Feeling dizzy or faint Get medical care right away if you have these signs. Doctors use drugs or surgery to remove the ectopic tissue so it doesn't damage your organs. Many women who have had ectopic pregnancies go on to have healthy pregnancies later. Dept. of Health and Human Services Office on Women's Health

MalaCards based summary: Ectopic Pregnancy, also known as extrauterine gestation or pregnancy, is related to placental site trophoblastic tumor and gestational choriocarcinoma, and has symptoms including pelvic pain and morning sickness. An important gene associated with Ectopic Pregnancy is CGB3 (Chorionic Gonadotropin Subunit Beta 3), and among its related pathways/superpathways is Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. The drugs Methotrexate and Letrozole have been mentioned in the context of this disorder. Affiliated tissues include uterus, heart and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and homeostasis/metabolism

Disease Ontology: ¹¹ A female reproductive system disease characterized by the implantation of the embryo outside the uterine cavity.

Wikipedia: ⁷⁵ Ectopic pregnancy is a complication of pregnancy in which the embryo attaches outside the uterus. Signs... more...

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Related Diseases for Ectopic Pregnancy

Diseases related to Ectopic Pregnancy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 362)

#	Related Disease	Score	Top Affiliating Genes
1	placental site trophoblastic tumor	32.0	HLA-G CGB5 CGB3 CGA
2	gestational choriocarcinoma	31.9	HLA-G AFP
3	hydatidiform mole, recurrent, 1	31.2	PSG1 CGB5 CGB3 CGA
4	infertility	31.2	PAEP LIF CGB3 CGA AMH
5	salpingitis	31.2	HSPD1 AMH
6	gestational trophoblastic neoplasm	31.1	PAPPA MIR517A CGB5 CGB3 CGA AFP
7	choriocarcinoma	31.0	LIF HLA-G CGB7 CGB5 CGB3 CGA
8	corpus luteum cyst	30.9	CGB5 AFP
9	ovarian cyst	30.9	PAEP CGA AMH AFP
10	ovarian hyperstimulation syndrome	30.8	CGB5 CGA AMH
11	dermoid cyst of ovary	30.8	AMH AFP
12	trophoblastic neoplasm	30.8	MIR517A CGB5 CGA AFP
13	placenta accreta	30.5	PAPPA CGB3 AFP
14	pregnancy loss, recurrent 1	30.5	PAEP HLA-G
15	cystic teratoma	30.5	AMH AFP
16	luteoma	30.4	CGA AMH
17	teratoma	30.3	CGB7 CGB5 CGB3 CGA AMH AFP
18	placenta praevia	30.3	PAPPA MIR525 MIR517A
19	placental abruption	30.3	PAPPA MIR517A LIF CGB5 CGB3 CGA
20	germ cell cancer	30.2	MIR517A LIF CGA AFP
21	adenomatoid tumor	30.1	CGB5 AFP
22	ornithosis	30.1	PIK3C2A HSPD1
23	down syndrome	30.0	PSG1 PAPPA CGB7 CGB5 CGB3 CGA
24	turner syndrome	29.9	PAPPA CGB3 AMH
25	oligohydramnios	29.9	PAPPA MIR517A CGA AFP
26	ovarian germ cell cancer	29.9	AMH AFP
27	pre-eclampsia	29.7	PSG1 PAPPA HLA-G CGB7 CGB3 CGA
28	pelvic inflammatory disease	11.4
29	chlamydia	11.2
30	diethylstilbestrol syndrome	11.2
31	hydatidiform mole, recurrent, 2	11.1
32	amenorrhea	10.8
33	endometriosis	10.6
34	appendicitis	10.5
35	mixed ductal-endocrine carcinoma	10.4	CGB7 CGB3
36	spastic ataxia, charlevoix-saguenay type	10.4
37	tatton-brown-rahman syndrome	10.4
38	extragonadal germ cell cancer	10.4	CGB5 AFP
39	ovarian mixed germ cell neoplasm	10.4	CGA AFP
40	rectum neuroendocrine neoplasm	10.4	PIK3C2A AFP
41	patellofemoral pain syndrome	10.3	CGB7 CGB3 CGA
42	intermediate malignant teratoma	10.3	PAPPA AFP
43	leydig cell hypoplasia type ii	10.3	LIF CGB7 CGB3
44	chorioangioma	10.3	PAPPA AFP
45	unilateral aplasia of the mullerian ducts	10.3
46	endodermal sinus tumor	10.3	CGB5 CGB3 AFP
47	tricuspid valve insufficiency	10.3	PAPPA MYH11 CGB3
48	testicular gonadoblastoma	10.3	AMH AFP
49	benign teratoma	10.3
50	orofaciodigital syndrome viii	10.3	PAPPA CGA AFP

Graphical network of the top 20 diseases related to Ectopic Pregnancy:

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Symptoms & Phenotypes for Ectopic Pregnancy

UMLS symptoms related to Ectopic Pregnancy:

pelvic pain; morning sickness

GenomeRNAi Phenotypes related to Ectopic Pregnancy according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-118	9.1	HLA-G
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-134	9.1	CGB5 CGB7
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-32	9.1	CGB5 CGB7
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-74	9.1	HLA-G

MGI Mouse Phenotypes related to Ectopic Pregnancy:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.97	AFP AMH BYSL CGA CGB3 CGB5
2	growth/size/body region	MP:0005378	9.77	AMH BYSL CGA CGB3 CGB5 CGB7
3	endocrine/exocrine gland	MP:0005379	9.32	AFP AMH CGA CGB3 CGB5 CGB7

Sources

Drugs & Therapeutics for Ectopic Pregnancy

Drugs for Ectopic Pregnancy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Methotrexate

Approved

Phase 3

1959-05-2, 59-05-2

4112 126941

Letrozole

Approved, Investigational

Phase 3

112809-51-5

3902

Estrogens

Phase 3

Estrogen Receptor Antagonists

Phase 3

Estrogen Antagonists

Phase 3

Hormones

Phase 3

Hormone Antagonists

Phase 3

Aromatase Inhibitors

Phase 3

Anesthetics

Phase 1, Phase 2

Sodium citrate

Approved, Investigational

68-04-2

23431961

Clomifene

Approved, Investigational

911-45-5

2800

Levoleucovorin

Approved, Experimental, Investigational

68538-85-2, 58-05-9, 73951-54-9

149436 6006

Estradiol

Approved, Investigational, Vet_approved

50-28-2

5757

Polyestradiol phosphate

Approved

28014-46-2

Progesterone

Approved, Vet_approved

57-83-0

5994

Acetylsalicylic acid

Approved, Vet_approved

50-78-2

2244

Cetrorelix

Approved, Investigational

120287-85-6

25074887

Follitropin

Approved, Vet_approved

97048-13-0, 146479-72-3, 9002-68-0

62819

Ganirelix

Approved

124904-93-4

44208957 16186319 16130966

Citric acid

Approved, Nutraceutical, Vet_approved

77-92-9

311

Folic acid

Approved, Nutraceutical, Vet_approved

59-30-3

6037

Creatine

Approved, Investigational, Nutraceutical

57-00-1

586

Cholecalciferol

Approved, Nutraceutical, Vet_approved

67-97-0, 1406-16-2

5280795 10883523

Enclomiphene

Investigational

15690-57-0

1548953

Imidacloprid

Vet_approved

105827-78-9

86418

Zuclomiphene

Citrate

Folic Acid Antagonists

Antirheumatic Agents

Folate

Vitamin B9

Vitamin B Complex

Antimetabolites

Immunosuppressive Agents

Dermatologic Agents

Immunologic Factors

Estradiol 3-benzoate

Estradiol 17 beta-cypionate

Endothelial Growth Factors

Mitogens

Arginine Vasopressin

Vasopressins

Pharmaceutical Solutions

Immunoglobulins

Antibodies

Vitamins

Calciferol

Calcium, Dietary

Fibrinolytic Agents

Antipyretics

Interventional clinical trials:

(show top 50) (show all 52)

#	Name	Status	NCT ID	Phase	Drugs
1	BHCG Level in Day 4,7, in Comparison to Day 10 as an Indicator for Treatment Success	Unknown status	NCT01860690	Phase 4	Methotrexate
2	Effectiveness Of Expectant Management In The Tubal Ectopic Pregnancy	Completed	NCT01876004	Phase 4	Methotrexate;Placebo
3	Evaluation of Different Doses of Aromatase Inhibitor Letrozole for the Treatment of Ectopic Pregnancy	Completed	NCT05198141	Phase 4	Letrozole tablets
4	Comparison of Single and Multiple-dose Methotrexate Therapy for Ectopic Pregnancy: a Clinical Trail	Completed	NCT01662167	Phase 4	Single;Multipe
5	Comparison of Two-dose and Single-dose Methotrexate Protocol for Ectopic Pregnancy: a Randomized Controlled Trial	Completed	NCT01855568	Phase 3
6	Two-Dose Methotrexate for Ectopic Pregnancy	Completed	NCT00194272	Phase 3	Methotrexate
7	Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location - a Randomized Clinical Trial of Women at Risk for an Ectopic Pregnancy: Active Treatment Versus No Treatment	Completed	NCT02152696	Phase 3	Methotrexate
8	Randomized Controlled Trial on Use of Letrozole in the Medical Management of Tubal Ectopic Pregnancies	Not yet recruiting	NCT04341545	Phase 3	Letrozole tablets
9	Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location -- a Randomized Clinical Trial of Women at Risk for an Ectopic Pregnancy	Terminated	NCT01800162	Phase 1, Phase 2	Methotrexate
10	Comparison of Conventional Laparoscopy and Natural Orifice Transluminal Endoscopic Surgery in the Surgical Treatment of Tubal Ectopic Pregnancy	Unknown status	NCT04315779
11	The Correlation Between Uterine Endometrial Pattern and Ectopic Pregnancy	Unknown status	NCT02963012
12	The Aromatase Inhibitor and Gnrh Antagonist Versus Methotrexate for Management of Undisturbed Ectopic Pregnancy	Unknown status	NCT04308343		Methotrexate;Letrozole;cetrotide
13	Clinical Application of Laparo-endoscopic Single-site Surgery and Natural Orifice Transluminal Endoscopic in Gynecology- the Chinese National Registry	Unknown status	NCT04096872
14	The Comparison of Reproductive Outcomes of Hsyteroscopic Metroplasty Versus Spontaneous Coitus Plus COH/IUI Cycles in Unexplained Infertile Women With Dysmorphic Uterus	Unknown status	NCT03579550
15	Adnexal Mass After Methotrexate Treatment for Ectopic Pregnancies	Unknown status	NCT03138694
16	Pragmatic Evaluation of Ultra-portable Ultrasound for a List of Indications in General Practice	Unknown status	NCT04127149
17	A RANDOMISED TRIAL COMPARING LAPARASCOPY VERSUS LAPAROTOMY IN THE MANAGEMENT OF WOMEN DIAGNOSED WITH ECTOPIC PREGNANCY	Completed	NCT01932957
18	Retrospective Cohort Study of Increased Risk of Ectopic Pregnancy Associated With Marked Variation of Estradiol During the Early Luteal Phase and High Progesterone on hCG Day in IVF	Completed	NCT02793089
19	The Impact of Salpingectomy and Single Dose Systemic Methotrexate Treatments on Ovarian Reserve in Ectopic Pregnancy	Completed	NCT02714998		Methotrexate
20	Incidence and Trend of Ectopic Pregnancy 2009-2018 - A Population-based Study	Completed	NCT03670784
21	Risk Factors for Ectopic Pregnancy: Comparison of Fresh and Warmed Transfers. Analysis of a 10 Years, a Single Center Experience.	Completed	NCT04325854
22	Evaluation of the Axonemal Dynein Heavy Chain 5 and Creatine Kinase Concentration in Cervical Fluid for Early Detection of the Ectopic Pregnancy	Completed	NCT02995356
23	Risk Factors as Predictors of Ectopic PRegnancy	Completed	NCT00194207
24	Serum Bank for Assessment of Markers of Ectopic Pregnancy	Completed	NCT00194168
25	Vascular Endothelial Growth Factor Levels in Ectopic Pregnancy	Completed	NCT01601964
26	Clinical Outcome of Laparoscopic Tubal Preservation Surgery for Ectopic Pregnancy	Completed	NCT03253588
27	Are Serum Levels of Vascular Endothelial Growth Factor a Marker for the Early Diagnosis of Ectopic Pregnancy?	Completed	NCT01261026
28	Ectopic Pregnancy and Thyroid Disorders	Completed	NCT05446012
29	Evaluation of Reproductive Outcomes After Expectant or Surgical Management of a Previous Episode of Tubal Ectopic Pregnancy	Completed	NCT05479786
30	Can Kisspeptin be Used for Differential Diagnosis of Early Pregnancies?	Completed	NCT04371991
31	The Effect of Serum Vitamin D and Calcium Levels in Ectopic Pregnancies	Completed	NCT03894735
32	Pregnancies of Uncertain Location or Viability Research	Completed	NCT02700789
33	Populationbased Screening for Urogenital Chlamydia Trachomatis Infections by Use of Home-Obtained and Mailed Samples: A Randomized Study	Completed	NCT00827970
34	Treatment Success With Two Doses of Methotrexate vs Single Dose of Methotrexate in Ectopic Tubal Pregnancy	Completed	NCT05208034		Methotrexate
35	Cornual Wedge Resection for Interstitial Pregnancy and Postoperative Outcome	Completed	NCT03974841
36	Sonographic Assessment and Visualization of Ectopics in Emergency Medicine (SAVE'EM)	Completed	NCT01322958
37	The Significance of Low-Dose Aspirin on Ovarian Responsiveness, Uterine Hemodynamics and Pregnancy Outcome in in Vitro Fertilization and in Intracytoplasmic Sperm Injection: A Randomized, Placebo-Controlled Double-Blind Study	Completed	NCT00683202		Acetylsalicylic acid;Placebo
38	Single Determination of Serum Activin A and Inhibin A in Predicting the Outcome of Pregnancies of Unknown Location (PUL) After IVF and Oocyte Donation.	Completed	NCT01589016
39	Point-of-care Ultrasound in Finland	Completed	NCT03327688
40	Serum Vascular Endothelial Growth Factor (VEGF) As a Marker for Tubal Pregnancy	Completed	NCT02973230
41	The Assessment of Biomarkers in Ectopic Pregnancy	Recruiting	NCT04176549
42	Assessment of Biomarkers in Pregnancy on Unknown Location and Ectopic Pregnancy	Recruiting	NCT04738370
43	Evaluation of Ipsilateral Tubal Patency After Conservative Medical or Surgical Treatment in Uncomplicated Ectopic Pregnancy, "Hospital General", Angola 2021-2022	Recruiting	NCT05136274		Medical treatment
44	Different Treatment Options for Tubal Ectopic Pregnancy:- A Systmatic Review	Recruiting	NCT04951011
45	Psychological Impact of Pregnancy of Unknown Location	Recruiting	NCT04739956
46	A Pilot Study to Test Rapid Acquisition of Point of Care Ultrasound for Various Applications	Recruiting	NCT02831556
47	- a Randomized Control Trial of Two hCG- Based Decision Support Models	Recruiting	NCT03461835
48	Analysis of the Molecular Composition of Tubal Cilia in Patients With or Without Ectopic Pregnancy	Active, not recruiting	NCT05374720
49	Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Women With Infertility Problems	Active, not recruiting	NCT04071574		Human Chorionic Gonadotropin (hCG);Gonadotropins;GNRH-A Triptorelin;GnRH antagonist
50	The Selection of Pregnancy for Patients After Tubal Ectopic Pregnancy Treatment In Pudong New Area	Not yet recruiting	NCT05498558

Search NIH Clinical Center for Ectopic Pregnancy

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Mifepristone

Cochrane evidence based reviews: pregnancy, ectopic

Sources

Genetic Tests for Ectopic Pregnancy

Sources

Anatomical Context for Ectopic Pregnancy

Organs/tissues related to Ectopic Pregnancy:

MalaCards : Uterus, Heart, Endothelial, Thyroid, Ovary, Placenta, Cervix

Sources

Publications for Ectopic Pregnancy

Articles related to Ectopic Pregnancy:

(show top 50) (show all 11590)

#	Title	Authors	PMID	Year
1	Identification of noninvasive diagnostic biomarkers for ectopic pregnancy using data-independent acquisition (DIA)proteomics: a pilot study. ⁶² ⁴¹	Ma D...Zhao L	36411308	2022
2	Ectopic pregnancy risk factors in infertile patients: a 10-year single center experience. ⁶² ⁴¹	Cirillo F...Levi-Setti PE	36443354	2022
3	Analysis of the type of cesarean scar pregnancy impacted on the effectiveness and safety of high intensity focused ultrasound combined with ultrasound-guided suction curettage treatment. ⁴¹	Peng Y...Jin P	36414236	2022
4	Are early human chorionic gonadotropin levels after methotrexate therapy a predictor of response in ectopic pregnancy? ⁵³ ⁶²	Nguyen Q...Silva C	20510964	2010
5	Human chorionic gonadotropin ratio of hemoperitoneum versus venous serum improves early diagnosis of ectopic pregnancy. ⁵³ ⁶²	Wang Y...Tong J	19046581	2010
6	Methotrexate treatment for ectopic pregnancy at the KK Women's and Children's Hospital, Singapore. ⁵³ ⁶²	Thia EW...Siow A	19960159	2009
7	Human chorionic gonadotropin tests. ⁵³ ⁶²	Cole LA	19817556	2009
8	Relevance of declines in serum human chorionic gonadotropin levels to the management of persistent ectopic pregnancy. ⁵³ ⁶²	Abe T...Takeshita T	20149048	2009
9	The use of serum inhibin A and activin A levels in predicting the outcome of 'pregnancies of unknown location'. ⁵³ ⁶²	Kirk E...Bourne T	19549702	2009
10	Laparoscopic treatment of early retroperitoneal abdominal pregnancy implanted on inferior vena cava. ⁵³ ⁶²	Bae SU...Park JS	19692871	2009
11	Human chorionic gonadotropin attracts regulatory T cells into the fetal-maternal interface during early human pregnancy. ⁵³ ⁶²	Schumacher A...Zenclussen AC	19380797	2009
12	The value of vascular endothelial growth factor, pregnancy-associated plasma protein-A, and progesterone for early differentiation of ectopic pregnancies, normal intrauterine pregnancies, and spontaneous miscarriages. ⁵³ ⁶²	Ugurlu EN...Ugur M	18402945	2009
13	Intramural pregnancy associated with adenomyosis after in vitro fertilization and embryo transfer: a case report. ⁵³ ⁶²	Choi DH...Kim JH	19438169	2009
14	Human chorionic gonadotropin and associated molecules. ⁵³ ⁶²	Cole LA	19099349	2009
15	Human choriogonadotrophin protein core and sugar branches heterogeneity: basic and clinical insights. ⁵³ ⁶²	de Medeiros SF...Norman RJ	18945715	2009
16	Ectopic pregnancy in adolescents. ⁵³ ⁶²	Vichnin M	18797271	2008
17	The use of serial human chorionic gonadotropin levels to establish a viable or a nonviable pregnancy. ⁵³ ⁶²	Chung K...Allen R	18825606	2008
18	The METEX study: methotrexate versus expectant management in women with ectopic pregnancy: a randomised controlled trial. ⁵³ ⁶²	van Mello NM...Hajenius PJ	18565217	2008
19	[Interstitial pregnancy: a rare type of ectopic pregnancy]. ⁵³ ⁶²	Timmerman E...Hajenius PJ	18491819	2008
20	Leukemia inhibitory factor (LIF) is immunohistochemically localized in tubal ectopic pregnancy. ⁵³ ⁶²	Guney M...Mungan T	18258286	2008
21	Spontaneous bilateral tubal pregnancies: a case report. ⁵³ ⁶²	Andrews J...Andrews J	18198068	2008
22	Comparison of the effect of single-dose and multiple-dose methotrexate therapy on tubal patency. ⁵³ ⁶²	Guven ES...Haberal A	17418839	2007
23	Deoxyribonucleic acid of Chlamydia trachomatis in fresh tissue from the Fallopian tubes of patients with ectopic pregnancy. ⁵³ ⁶²	Bjartling C...Persson K	17280761	2007
24	Prognostic value of human chorionic gonadotropin changes after methotrexate injection for ectopic pregnancy. ⁵³ ⁶²	Agostini A...Blanc B	17418833	2007
25	Development of dual-enzyme-based simultaneous immunoassay for measurement of progesterone and human chorionic gonadotropin. ⁵³ ⁶²	Basu A...Shrivastav TG	17540332	2007
26	Rupture of ectopic pregnancy with minimally detectable beta-human chorionic gonadotropin levels: a report of 2 cases. ⁵³ ⁶²	Fu J...Lathi RB	17694977	2007
27	Establishing a human chorionic gonadotropin cutoff to guide methotrexate treatment of ectopic pregnancy: a systematic review. ⁵³ ⁶²	Menon S...Barnhart KT	17173905	2007
28	Hyperglycosylated hCG: a variant with separate biological functions to regular hCG. ⁵³ ⁶²	Cole LA...Khanlian SA	17081684	2007
29	Human chorionic gonadotropin profile for women with ectopic pregnancy. ⁵³ ⁶²	Silva C...Barnhart K	16507931	2006
30	The practical application of a mathematical model to predict the outcome of pregnancies of unknown location. ⁵³ ⁶²	Kirk E...Bourne T	16456845	2006
31	Suspected ectopic pregnancy. ⁵³ ⁶²	Seeber BE...Barnhart KT	16449130	2006
32	Creatine phosphokinase in ectopic pregnancy revisited: significant diagnostic value of its MB and MM isoenzyme fractions. ⁵³ ⁶²	Katsikis I...Panidis D	16389014	2006
33	Ectopic pregnancy in a caesarean scar: a case report. ⁵³ ⁶²	Persadie RJ...Stopps RG	16524528	2005
34	Diagnostic accuracy of varying discriminatory zones for the prediction of ectopic pregnancy in women with a pregnancy of unknown location. ⁵³ ⁶²	Condous G...Bourne T	16308901	2005
35	Expression of beta-subunit of HCG genes during normal and failed pregnancy. ⁵³ ⁶²	Rull K...Laan M	16123088	2005
36	A molar pregnancy detected by following beta-human chorionic gonadotropin levels after a first trimester loss. ⁵³ ⁶²	Dresang LT	16322422	2005
37	The value of a single combined measurement of VEGF, glycodelin, progesterone, PAPP-A, HPL and LIF for differentiating between ectopic and abnormal intrauterine pregnancy. ⁵³ ⁶²	Daponte A...Messinis IE	16055453	2005
38	Evaluation of the relationship between endometrial thickness and failure of single-dose methotrexate in ectopic pregnancy. ⁵³ ⁶²	Takacs P...Verma U	16001188	2005
39	Presence of a yolk sac on transvaginal sonography is the most reliable predictor of single-dose methotrexate treatment failure in ectopic pregnancy. ⁵³ ⁶²	Bixby S...Kuligowska E	15840789	2005
40	Risk factors associated with the rupture of tubal ectopic pregnancy. ⁵³ ⁶²	Latchaw G...Burzawa J	16141721	2005
41	Pre- and post-treatment patterns of human chorionic gonadotropin for early detection of persistence after a single dose of methotrexate for ectopic pregnancy. ⁵³ ⁶²	Natale A...Busacca M	15474251	2004
42	Ectopic pregnancy: a review. ⁵³ ⁶²	Dialani V...Levine D	15322388	2004
43	Symptomatic patients with an early viable intrauterine pregnancy: HCG curves redefined. ⁵³ ⁶²	Barnhart KT...Guo W	15229000	2004
44	Leukemia inhibitory factor and homeobox a10 gene expression in an ectopic pregnancy model for implantation. ⁵³ ⁶²	McMinn MJ...Cowan BD	15167855	2004
45	[Conservative treatment of ectopic pregnancy in a 27 years old patient with stage-Ia ovarian cancer after conservative surgical treatment and chemotherapy]. ⁵³ ⁶²	Malinowski A...Ciesielski A	15738608	2004
46	Human chorionic gonadotropin isoforms in the diagnosis of ectopic pregnancy. ⁵³ ⁶²	Borrelli PT...Iles RK	14633876	2003
47	Implantation-dependent expression of trophinin by maternal fallopian tube epithelia during tubal pregnancies: possible role of human chorionic gonadotrophin on ectopic pregnancy. ⁵³ ⁶²	Nakayama J...Fukuda MN	14633596	2003
48	[Management of non-surgical treatment of ectopic pregnancy]. ⁵³ ⁶²	Gervaise A	14699320	2003
49	Evidence of a limited contribution of feto-maternal interactions to trophoblast differentiation along the invasive pathway. ⁵³ ⁶²	Goffin F...Foidart JM	12889991	2003
50	Human chorionic gonadotropin testing for early pregnancy viability and complications. ⁵³ ⁶²	Davies S...Cole LA	12848444	2003

Sources

Genes for Ectopic Pregnancy

Genes related to Ectopic Pregnancy (0 elite genes):

(show all 32)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CGB3	Chorionic Gonadotropin Subunit Beta 3	Protein Coding	32.3	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7514671 10577398 9166176 (more) 1534728 8745091 11316311 1375646 7529199 9144058 9565137 10689006 10944368 1548638 8592317 9250634 10203662 16001188 16322422 19692871 9026508 19438169 20510964 7739852 15840789 16141721 7526807 17694977 18797271 17418839 1813010
2	CGA	Glycoprotein Hormones, Alpha Polypeptide	Protein Coding	24.28	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12190842 7682316 1379268 (more) 10834324 1386659 12796988 8501201 1829344 9021384 8304901 7824243 7504682 10469714 14699320 7515072 1587935 16449130 9573753 10548636 1551949 8408532 7936515 9756316 11702153 17418833 7519843 7906763 8408533 2253352 2143278 10711833 8655939 1551947 18198068 12421174 9853887 7851573 8612849 7794849 2009998 2226912 19960159 9207811 8671453 8272309 2056029 8671235 14633596 12637792 11937130 11209628 8567799 19046581 19549702 18945715 18565217 10875883 9050473 9611704 11267725 12569177 2149909
3	CGB5	Chorionic Gonadotropin Subunit Beta 5	Protein Coding	23.72	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16507931 7614131 14633876 (more) 16308901 9363257 11750970 12749441 12848444 17173905 19380797 9172792 12220770 18491819 7672142 1656352 20149048 11788181 17540332 11728769 10577398 7542189 8150103 2071058 2115257 2156909 15474251 7473443 16456845 15738608 11311774 10338231 9605458 9356647 8844135 8263872 19817556 18825606 12215330 1790603 11448464 9407760 1683654 2001750 15229000 8187922 1525465 1754988 2148969 19099349 7982771 1387166 12738132 7529199 17081684 12780426 8745091
4	CGB7	Chorionic Gonadotropin Subunit Beta 7	Protein Coding	20.69	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1379268 1826038 8501201 (more) 16123088 10735600 8671235 7515072 8567799 10522077 15322388 16524528
5	PAEP	Progestagen Associated Endometrial Protein	Protein Coding	18.79	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7947525 12781411 1551949 (more) 16055453
6	PAPPA	Pappalysin 1	Protein Coding	17.57	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18402945 11750960 7504682 (more) 16055453
7	LIF	LIF Interleukin 6 Family Cytokine	Protein Coding	17.36	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11349161 15167855 18258286 (more) 9526705 16055453
8	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	14.4	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10883946 16389014 11043625
9	MYH11	Myosin Heavy Chain 11	Protein Coding	12.67	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10918100 11719740
10	AFP	Alpha Fetoprotein	Protein Coding	12.08	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
11	TRO	Trophinin	Protein Coding	11.66	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
12	TROAP	Trophinin Associated Protein	Protein Coding	11.3	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
13	BYSL	Bystin Like	Protein Coding	11.2	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
14	MIR517A	MicroRNA 517a	RNA Gene	9.77	DISEASES inferred ¹⁴ ¹⁴
15	HSPD1	Heat Shock Protein Family D (Hsp60) Member 1	Protein Coding	9.73	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	2205652 9619577 17280761 (more) 7679373
16	MIR525	MicroRNA 525	RNA Gene	9.28	DISEASES inferred ¹⁴ ¹⁴
17	HLA-G	Major Histocompatibility Complex, Class I, G	Protein Coding	8.18	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	10825371 11925408 12889991 (more) 11137214
18	MIRLET7A1	MicroRNA Let-7a-1	RNA Gene	7.58	DISEASES inferred ¹⁴ ¹⁴
19	PSG1	Pregnancy Specific Beta-1-Glycoprotein 1	Protein Coding	7.45	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	2364798
20	AMH	Anti-Mullerian Hormone	Protein Coding	7.43	DISEASES inferred ¹⁴
21	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	6.79	DISEASES inferred ¹⁴
22	MB	Myoglobin	Protein Coding	6.74	GeneCards inferred via : Publications (show sections)
23	CSH1	Chorionic Somatomammotropin Hormone 1	Protein Coding	6.69	DISEASES inferred ¹⁴
24	MIR371A	MicroRNA 371a	RNA Gene	6.61	DISEASES inferred ¹⁴ ¹⁴
25	MIR125A	MicroRNA 125a	RNA Gene	6.6	DISEASES inferred ¹⁴ ¹⁴
26	CSH2	Chorionic Somatomammotropin Hormone 2	Protein Coding	6.57	DISEASES inferred ¹⁴
27	MIR1247	MicroRNA 1247	RNA Gene	6.53	DISEASES inferred ¹⁴ ¹⁴
28	MIR542	MicroRNA 542	RNA Gene	6.34	DISEASES inferred ¹⁴ ¹⁴
29	MIR181A1	MicroRNA 181a-1	RNA Gene	6.34	DISEASES inferred ¹⁴ ¹⁴
30	HCG21	HLA Complex Group 21	RNA Gene	6.29	DISEASES inferred ¹⁴
31	MIR1288	MicroRNA 1288	RNA Gene	6.27	DISEASES inferred ¹⁴
32	OXT	Oxytocin/Neurophysin I Prepropeptide	Protein Coding	6.22	DISEASES inferred ¹⁴

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Variations for Ectopic Pregnancy

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Expression for Ectopic Pregnancy

Search GEO for disease gene expression data for Ectopic Pregnancy.

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Pathways for Ectopic Pregnancy

Pathways related to Ectopic Pregnancy according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors ⁶⁶ Show member pathways Activation of the TFAP2 (AP-2) family of transcription factors ⁶⁶ Negative regulation of activity of TFAP2 (AP-2) family transcription factors ⁶⁶ TFAP2 (AP-2) family regulates transcription of cell cycle factors ⁶⁶ TFAP2 (AP-2) family regulates transcription of growth factors and their receptors ⁶⁶ TFAP2 (AP-2) family regulates transcription of other transcription factors ⁶⁶ TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation ⁶⁶	10.87	HSPD1 CGB5 CGB3 CGA

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GO Terms for Ectopic Pregnancy

Cellular components related to Ectopic Pregnancy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	10.11	PSG1 PAPPA PAEP LIF HLA-G CGB7
2	extracellular space	GO:0005615	10	AFP AMH CGA CGB3 CGB5 CGB7
3	pituitary gonadotropin complex	GO:0061696	9.02	CGB5 CGB3 CGA

Biological processes related to Ectopic Pregnancy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone-mediated signaling pathway	GO:0009755	9.35	CGB5 CGB3 CGA
2	gonad development	GO:0008406	9.16	CGA AMH
3	female gamete generation	GO:0007292	9.02	CGB7 CGB5 CGB3