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MCID: ECT026
MIFTS: 50

Ectopic Pregnancy

Categories: Fetal diseases, Rare diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Ectopic Pregnancy

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MalaCards integrated aliases for Ectopic Pregnancy:

Name: Ectopic Pregnancy 12 74 52 42 15 71 32
Ectopic Pregnancies 15
Pregnancy, Ectopic 43
Pregnancy Ectopic 54
Eccyesis 12

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:0060329
ICD9CM 34 633
MeSH 43 D011271
NCIt 49 C34945
SNOMED-CT 67 34801009
ICD10 32 O00 O00.9
UMLS 71 C0032987
Sources

Summaries for Ectopic Pregnancy

About this section
MedlinePlus : 42 The uterus, or womb, is the place where a baby grows when a woman is pregnant. If you have an ectopic pregnancy, the fertilized egg grows in the wrong place, outside the uterus, usually in the fallopian tubes. The result is usually a miscarriage. Ectopic pregnancy can be a medical emergency if it ruptures. Signs of ectopic pregnancy include Abdominal pain Shoulder pain Vaginal bleeding Feeling dizzy or faint Get medical care right away if you have these signs. Doctors use drugs or surgery to remove the ectopic tissue so it doesn't damage your organs. Many women who have had ectopic pregnancies go on to have healthy pregnancies later. Dept. of Health and Human Services Office on Women's Health

MalaCards based summary : Ectopic Pregnancy, also known as ectopic pregnancies, is related to hydatidiform mole, recurrent, 1 and infertility, and has symptoms including pelvic pain and morning sickness. An important gene associated with Ectopic Pregnancy is CGB3 (Chorionic Gonadotropin Subunit Beta 3), and among its related pathways/superpathways are NF-KappaB Family Pathway and Rheumatoid arthritis. The drugs Gemifloxacin and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include uterus, testes and ovary, and related phenotypes are growth/size/body region and homeostasis/metabolism

Disease Ontology : 12 A female reproductive system disease characterized by the implantation of the embryo outside the uterine cavity.

Wikipedia : 74 Ectopic pregnancy is a complication of pregnancy in which the embryo attaches outside the uterus. Signs... more...

Sources

Related Diseases for Ectopic Pregnancy

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Diseases related to Ectopic Pregnancy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 312)
# Related Disease Score Top Affiliating Genes
1 hydatidiform mole, recurrent, 1 33.2 CGB5 CGB3 CGA
2 infertility 31.3 PAEP LIF GNRH1 CGA
3 choriocarcinoma 31.1 LIF CGB7 CGB5 CGB3 CGA
4 ovarian cyst 31.0 VEGFA PAEP GNRH1 CGA
5 corpus luteum cyst 30.9 GNRH1 CGB5
6 endometriosis 30.8 VEGFA PAEP LIF IL1B GNRH1 CGA
7 ovarian hyperstimulation syndrome 30.8 VEGFA GNRH1 CGB5 CGA
8 teratoma 30.7 CGB7 CGB5 CGB3 CGA
9 triploidy 30.7 PAPPA CGB7 CGA
10 placental site trophoblastic tumor 30.6 VEGFA CGB5 CGB3
11 placenta praevia 30.6 PGF PAPPA
12 adenomyosis 30.6 VEGFA LIF GNRH1
13 chromosomal triplication 30.6 PAPPA CGB7 CGB3
14 exanthem 30.5 VEGFA PIK3C2A IL1B
15 eclampsia 30.4 VEGFA PGF PAPPA
16 placenta disease 30.2 VEGFA PGF PAPPA IL1B CGB7 CGB5
17 pain agnosia 30.2 IL1B FAAH CNR1
18 oligohydramnios 30.1 PGF PAPPA CGA
19 endometrial adenocarcinoma 30.0 VEGFA PAEP MUC1
20 irritable bowel syndrome 29.8 TLR2 IL1B CNR1
21 post-traumatic stress disorder 29.7 IL1B FAAH CNR1
22 down syndrome 29.5 PGF PAPPA CGB7 CGB5 CGB3 CGA
23 pre-eclampsia 29.2 VEGFA PGF PAPPA IL1B FST CGB7
24 pelvic inflammatory disease 11.8
25 chlamydia 11.6
26 gestational trophoblastic neoplasm 11.6
27 hydatidiform mole, recurrent, 2 11.2
28 diethylstilbestrol syndrome 11.2
29 mixed germ cell tumor 10.6 CGB3 CGA
30 sacrococcygeal teratoma 10.6 CGB7 CGA
31 testicular seminoma 10.6 CGB3 CGA
32 anorchia 10.6 CGB5 CGA
33 amenorrhea 10.6
34 nonseminomatous germ cell tumor 10.6 CGB7 CGB5
35 trisomy 22 10.6 PAPPA CGB7
36 mixed ductal-endocrine carcinoma 10.6 CGB7 CGB3
37 patterned macular dystrophy 10.6 VEGFA FST
38 tinea favosa 10.6 CGB7 CGB3
39 oocyte maturation defect 1 10.5 FST CGA
40 salpingitis 10.5
41 germinoma 10.5 CGB5 CGB3 CGA
42 localized pulmonary fibrosis 10.5 MUC1 IL1B
43 autoimmune encephalitis 10.5 FAAH CNR1
44 gynecomastia 10.5 GNRH1 CGB5 CGA
45 uremic pruritus 10.5 IL1B CNR1
46 glomeruloid hemangioma 10.5 VEGFA IL1B
47 mild pre-eclampsia 10.4 VEGFA PGF PAPPA
48 seminoma 10.4 CGB7 CGB5 CGB3 CGA
49 prosthetic joint infection 10.4 TLR2 IL1B
50 polysubstance abuse 10.4 FAAH CNR1

Graphical network of the top 20 diseases related to Ectopic Pregnancy:



Diseases related to Ectopic Pregnancy
Sources

Symptoms & Phenotypes for Ectopic Pregnancy

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UMLS symptoms related to Ectopic Pregnancy:


pelvic pain, morning sickness

MGI Mouse Phenotypes related to Ectopic Pregnancy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.93 CGA CNR1 FST GNRH1 IL1B LIF
2 homeostasis/metabolism MP:0005376 9.77 CGA CNR1 FAAH FST GNRH1 IL1B
3 integument MP:0010771 9.32 CNR1 FAAH FST GNRH1 IL1B LIF
Sources

Drugs & Therapeutics for Ectopic Pregnancy

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Drugs for Ectopic Pregnancy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 101)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemifloxacin Approved, Investigational Phase 4 175463-14-6 5464436 9571107
2
Azithromycin Approved Phase 4 83905-01-5 447043 55185
3
Methotrexate Approved Phase 4 59-05-2, 1959-05-2 126941
4
leucovorin Approved Phase 4 58-05-9 6006 143
5
Cefotaxime Approved Phase 4 63527-52-6 5742673 456256
6
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
7 Progestins Phase 4
8 Gentamicins Phase 4
9 Immunologic Factors Phase 4
10 Vitamin B Complex Phase 4
11 Folic Acid Antagonists Phase 4
12 Immunosuppressive Agents Phase 4
13 Folate Phase 4
14 Dermatologic Agents Phase 4
15 Antirheumatic Agents Phase 4
16 Antimetabolites Phase 4
17 Vitamin B9 Phase 4
18 Anti-Bacterial Agents Phase 4
19 Antibiotics, Antitubercular Phase 4
20 Hormone Antagonists Phase 4
21 Hormones Phase 4
22 Chorionic Gonadotropin Phase 4
23 Antineoplastic Agents, Hormonal Phase 4
24 Contraceptive Agents Phase 4
25 Triptorelin Pamoate Phase 4
26 Follicle Stimulating Hormone Phase 4
27
Sodium citrate Approved, Investigational Phase 3 68-04-2
28
Lactitol Approved, Investigational Phase 3 585-88-6, 585-86-4 493591
29
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
30
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
31
Copper Approved, Investigational Phase 3 7440-50-8 27099
32
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
33
Citric acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
34
Enclomiphene Investigational Phase 3 15690-57-0
35 Citrate Phase 3
36 Clomiphene Phase 3
37 Zuclomiphene Phase 3
38 Calcium, Dietary Phase 3
39 Fibrinolytic Agents Phase 3
40 Anticoagulants Phase 3
41 calcium heparin Phase 3
42 Copper Supplement Phase 3
43 Estrogen Antagonists Phase 3
44 Estrogen Receptor Antagonists Phase 3
45 Estrogens Phase 3
46 Aromatase Inhibitors Phase 3
47
Calcium Nutraceutical Phase 3 7440-70-2 271
48
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
49
Nifedipine Approved Phase 2 21829-25-4 4485
50 Vasodilator Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 103)
# Name Status NCT ID Phase Drugs
1 A RANDOMISED TRIAL COMPARING LAPARASCOPY VERSUS LAPAROTOMY IN THE MANAGEMENT OF WOMEN DIAGNOSED WITH ECTOPIC PREGNANCY Unknown status NCT01932957 Phase 4
2 BHCG Level in Day 4,7, in Comparison to Day 10 as an Indicator for Treatment Success Unknown status NCT01860690 Phase 4 Methotrexate
3 Prospective Study, Randomized Controlled Trial Between Medical Treatment by Methotrexate Versus Conservative Surgical Treatment (Group 1) and Conservative Versus Radical Surgical Treatment (Group 2) to Evaluate Subsequent Fertility Unknown status NCT00137982 Phase 4
4 Randomized, Open-label, Multicenter Study of Azithromycin Compared With Doxycycline for Treating Anorectal Chlamydia Trachomatis Infection Concomitant to a Vaginal Infection Unknown status NCT03532464 Phase 4 azithromycin;doxycycline
5 Effectiveness Of Expectant Management In The Tubal Ectopic Pregnancy Completed NCT01876004 Phase 4 Methotrexate;Placebo
6 Comparison of Single and Multiple-dose Methotrexate Therapy for Ectopic Pregnancy: a Clinical Trail Completed NCT01662167 Phase 4 Single;Multipe
7 A Phase IV, Open-label, Post Marketing, Prospective, Randomized, Controlled, Multicentre, Multinational Study to Investigate Tailoring of Recombinant FSH Use in Ovulation Stimulation Treatment in Chronic Anovulatory Subjects (WHO Group II) Completed NCT01081626 Phase 4 Recombinant FSH (follitropin alpha)
8 Randomized Clinical Trial Evaluating the Efficacy of Gentamicin/Azithromycin and Gemifloxacin/Azithromycin Combination Therapies as an Alternative Regimen for Uncomplicated Urogenital Gonorrhea Completed NCT00926796 Phase 4 Azithromycin;Gentamicin;Gemifloxacin
9 Surgery Alone Versus Methotrexate Before Surgery in Cases of First Trimester Cesarean Scar Pregnancy: a Randomized Controlled Trial Recruiting NCT04379219 Phase 4 Methotrexate
10 The Effectiveness and Safety of the Early Follicular Phase Prolonged Down-regulation Protocol for Controlled Ovarian Hyperstimulation: a Randomized, Paralleled, Controlled, Multicenter Trial Not yet recruiting NCT03809221 Phase 4 Triptorelin acetate
11 Effect of Acupuncture Pre-treatment Combined With Letrozole on Live Birth in Infertile Women With Polycystic Ovary Syndrome Unknown status NCT02491320 Phase 3 Letrozole
12 Two-Dose Methotrexate for Ectopic Pregnancy Completed NCT00194272 Phase 3 Methotrexate
13 Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location - a Randomized Clinical Trial of Women at Risk for an Ectopic Pregnancy: Active Treatment Versus No Treatment Completed NCT02152696 Phase 3 Methotrexate
14 Comparison of Two-dose and Single-dose Methotrexate Protocol for Ectopic Pregnancy: a Randomized Controlled Trial Completed NCT01855568 Phase 3
15 Concomitant Administration of Follicle-stimulating Hormone at the Time of Human Chorionic Gonadotropin Trigger in Letrozole Stimulated Intrauterine Insemination Cycles in Women With Unexplained Infertility Completed NCT02739516 Phase 3 Human chorionic gonadotropin;FSH co-trigger;Letrozole
16 Study On The Effects of Letrozole And Clomiphene Citrate For Induction of Ovulation In Polycystic Ovarian Syndrome(PCOS) Completed NCT01577017 Phase 3 Letrozole
17 Pregnancy Outcomes in Women With Unexplained Recurrent Pregnancy Loss Treated With Low Dose Aspirin and Unfractionated Heparin Recruiting NCT02144064 Phase 3 Heparin
18 A Phase 3, Prospective, Multi-Center, Single-Arm, Open-Label Study to Evaluate VeraCeptâ„¢, a Long-Acting Reversible Intrauterine Contraceptive for Contraceptive Efficacy, Safety, and Tolerability Active, not recruiting NCT03633799 Phase 3 VeraCept
19 Randomized Controlled Trial on Use of Letrozole in the Medical Management of Tubal Ectopic Pregnancies Not yet recruiting NCT04341545 Phase 3 Letrozole tablets
20 Laparoscopic Repair Of Cesarean Scar Niche: Randomized Controlled Trial. Not yet recruiting NCT04307524 Phase 2, Phase 3 medical treatment in the form of combined hormonal contraception
21 Luteal Phase Estradiol Support for In Vitro Fertilization/Intracytoplasmic Sperm Injection Cycles: a Randomized, Controlled Study Unknown status NCT02677259 Phase 2 17-beta estradiol;Micronized progesterone
22 The Influence of Nifedipine Treatment on Uterine Contractility During Frozen Embryo Transfer Unknown status NCT02072291 Phase 2 Nifedipine
23 Clinical Promotion Research of Complex Treatment With TCM to Diagnosis and Treatment on Different Syndrome Types of Pelvic Inflammatory Disease Sequelae Unknown status NCT02972151 Phase 2 Comprehensive treatment of TCM
24 Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location -- a Randomized Clinical Trial of Women at Risk for an Ectopic Pregnancy Terminated NCT01800162 Phase 1, Phase 2 Methotrexate
25 A Randomized, Double-Blind, Placebo Controlled Phase I Study of an Amino Acid For the Reduction of Peritoneal Adhesions in Adult Females Undergoing a Laparoscopic Salpingostomy for the Removal of an Ectopic Pregnancy Unknown status NCT01701193 Phase 1 Amino Acid;Saline
26 The Correlation Between Uterine Endometrial Pattern and Ectopic Pregnancy Unknown status NCT02963012
27 Adnexal Mass After Methotrexate Treatment for Ectopic Pregnancies Unknown status NCT03138694
28 Office Hysteroscopy as a Diagnostic Tool of Pregnancy of Unknown Location Unknown status NCT02637739
29 Safety and Effectiveness of Transvaginal Resection of Pregnancy Tissue in the Treatment of Caesarean Scar Pregnancy Unknown status NCT01916746
30 A Randomized Prospective Double Blind Study of Misoprostol Administration in Asymptomatic Patients With Pregnancies of Unknown Location Unknown status NCT02581761 CYTOTEC
31 The Histological and Genetic Investigation of Cells, Fluid and Tissue in the Uterine Cavity, Using the Uterine Irrigation Method, in Patients Who Suffer From Unexplained Infertility and Hereditary Genetic Disease, and Who Require PGD Scans. Unknown status NCT02676479
32 A Comparison of Ongoing Pregnancy Rate Between Cleavage Stage and Early Compacting Embryo Transfer at 66±2 Hours After ICSI Using Single Step Culture Medium Unknown status NCT02987075
33 Optimizing Technology-Delivered Interventions for Smoking in Pregnancy: The Mommy Check-Up Study. Unknown status NCT02340624
34 Keller Fire Rescue Study of Prehospital Ultrasound Use Unknown status NCT01074112
35 Prospective Randomized Controlled Trial Comparing Two Different Embryo Transfer (ET) Catheters Unknown status NCT03161119
36 A Randomized Double Blinded Controlled Study Comparing a Shorter Exposure of Oocyte to Spermatozoa Versus a Standard Incubation on the Live Birth Rate of In-vitro Fertilization Treatment Unknown status NCT02534857
37 Relationship Between Nitric Oxide (NO) in Follicular Fluid and Sperm Fertilization Ability Unknown status NCT03307655
38 Cornual Wedge Resection for Interstitial Pregnancy and Postoperative Outcome Completed NCT03974841
39 The Effect of Serum Vitamin D and Calcium Levels in Ectopic Pregnancies Completed NCT03894735
40 Clinical Outcome of Laparoscopic Tubal Preservation Surgery for Ectopic Pregnancy Completed NCT03253588
41 Sonographic Assessment and Visualization of Ectopics in Emergency Medicine (SAVE'EM) Completed NCT01322958
42 The Impact of Salpingectomy and Single Dose Systemic Methotrexate Treatments on Ovarian Reserve in Ectopic Pregnancy Completed NCT02714998 Methotrexate
43 Single Determination of Serum Activin A and Inhibin A in Predicting the Outcome of Pregnancies of Unknown Location (PUL) After IVF and Oocyte Donation. Completed NCT01589016
44 Evaluation of the Axonemal Dynein Heavy Chain 5 and Creatine Kinase Concentration in Cervical Fluid for Early Detection of the Ectopic Pregnancy Completed NCT02995356
45 Serum Bank for Assessment of Markers of Ectopic Pregnancy Completed NCT00194168
46 Retrospective Cohort Study of Increased Risk of Ectopic Pregnancy Associated With Marked Variation of Estradiol During the Early Luteal Phase and High Progesterone on hCG Day in IVF Completed NCT02793089
47 Can Kisspeptin be Used for Differential Diagnosis of Early Pregnancies? Completed NCT04371991
48 Vascular Endothelial Growth Factor Levels in Ectopic Pregnancy Completed NCT01601964
49 Serum Vascular Endothelial Growth Factor (VEGF) As a Marker for Tubal Pregnancy Completed NCT02973230
50 Are Serum Levels of Vascular Endothelial Growth Factor a Marker for the Early Diagnosis of Ectopic Pregnancy? Completed NCT01261026

Search NIH Clinical Center for Ectopic Pregnancy

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Mifepristone

Cochrane evidence based reviews: pregnancy, ectopic

Sources

Genetic Tests for Ectopic Pregnancy

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Sources

Anatomical Context for Ectopic Pregnancy

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MalaCards organs/tissues related to Ectopic Pregnancy:

40
Uterus, Testes, Ovary, Endothelial, Heart, Placenta, Cervix
Sources

Publications for Ectopic Pregnancy

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Articles related to Ectopic Pregnancy:

(show top 50) (show all 8776)
# Title Authors PMID Year
1
Anesthetic efficacy of propofol combined butorphanol in laparoscopic surgery for ectopic pregnancy: A protocol of systematic review and meta-analysis. 42 61
32443375 2020
2
Ectopic pregnancy and its long-term results. 61 42
32124824 2020
3
Imaging of Acute Pelvic Pain: Pregnant (Ectopic and First-trimester Viability Updated). 42
32044011 2020
4
Are early human chorionic gonadotropin levels after methotrexate therapy a predictor of response in ectopic pregnancy? 54 61
20510964 2010
5
Human chorionic gonadotropin ratio of hemoperitoneum versus venous serum improves early diagnosis of ectopic pregnancy. 61 54
19046581 2010
6
Methotrexate treatment for ectopic pregnancy at the KK Women's and Children's Hospital, Singapore. 54 61
19960159 2009
7
The use of serum inhibin A and activin A levels in predicting the outcome of 'pregnancies of unknown location'. 54 61
19549702 2009
8
Relevance of declines in serum human chorionic gonadotropin levels to the management of persistent ectopic pregnancy. 61 54
20149048 2009
9
Laparoscopic treatment of early retroperitoneal abdominal pregnancy implanted on inferior vena cava. 54 61
19692871 2009
10
Human chorionic gonadotropin attracts regulatory T cells into the fetal-maternal interface during early human pregnancy. 54 61
19380797 2009
11
Intramural pregnancy associated with adenomyosis after in vitro fertilization and embryo transfer: a case report. 54 61
19438169 2009
12
Human choriogonadotrophin protein core and sugar branches heterogeneity: basic and clinical insights. 54 61
18945715 2009
13
Ectopic pregnancy in adolescents. 54 61
18797271 2008
14
The use of serial human chorionic gonadotropin levels to establish a viable or a nonviable pregnancy. 54 61
18825606 2008
15
The METEX study: methotrexate versus expectant management in women with ectopic pregnancy: a randomised controlled trial. 61 54
18565217 2008
16
[Interstitial pregnancy: a rare type of ectopic pregnancy]. 54 61
18491819 2008
17
Spontaneous bilateral tubal pregnancies: a case report. 61 54
18198068 2008
18
Leukemia inhibitory factor (LIF) is immunohistochemically localized in tubal ectopic pregnancy. 61 54
18258286 2008
19
Comparison of the effect of single-dose and multiple-dose methotrexate therapy on tubal patency. 61 54
17418839 2007
20
Deoxyribonucleic acid of Chlamydia trachomatis in fresh tissue from the Fallopian tubes of patients with ectopic pregnancy. 61 54
17280761 2007
21
Prognostic value of human chorionic gonadotropin changes after methotrexate injection for ectopic pregnancy. 61 54
17418833 2007
22
Rupture of ectopic pregnancy with minimally detectable beta-human chorionic gonadotropin levels: a report of 2 cases. 54 61
17694977 2007
23
Establishing a human chorionic gonadotropin cutoff to guide methotrexate treatment of ectopic pregnancy: a systematic review. 54 61
17173905 2007
24
Human chorionic gonadotropin profile for women with ectopic pregnancy. 54 61
16507931 2006
25
The practical application of a mathematical model to predict the outcome of pregnancies of unknown location. 61 54
16456845 2006
26
Suspected ectopic pregnancy. 61 54
16449130 2006
27
Creatine phosphokinase in ectopic pregnancy revisited: significant diagnostic value of its MB and MM isoenzyme fractions. 54 61
16389014 2006
28
Ectopic pregnancy in a caesarean scar: a case report. 61 54
16524528 2005
29
Diagnostic accuracy of varying discriminatory zones for the prediction of ectopic pregnancy in women with a pregnancy of unknown location. 61 54
16308901 2005
30
Expression of beta-subunit of HCG genes during normal and failed pregnancy. 54 61
16123088 2005
31
The value of a single combined measurement of VEGF, glycodelin, progesterone, PAPP-A, HPL and LIF for differentiating between ectopic and abnormal intrauterine pregnancy. 61 54
16055453 2005
32
Evaluation of the relationship between endometrial thickness and failure of single-dose methotrexate in ectopic pregnancy. 61 54
16001188 2005
33
Presence of a yolk sac on transvaginal sonography is the most reliable predictor of single-dose methotrexate treatment failure in ectopic pregnancy. 61 54
15840789 2005
34
Risk factors associated with the rupture of tubal ectopic pregnancy. 54 61
16141721 2005
35
Pre- and post-treatment patterns of human chorionic gonadotropin for early detection of persistence after a single dose of methotrexate for ectopic pregnancy. 54 61
15474251 2004
36
Ectopic pregnancy: a review. 61 54
15322388 2004
37
Symptomatic patients with an early viable intrauterine pregnancy: HCG curves redefined. 54 61
15229000 2004
38
Leukemia inhibitory factor and homeobox a10 gene expression in an ectopic pregnancy model for implantation. 61 54
15167855 2004
39
[Conservative treatment of ectopic pregnancy in a 27 years old patient with stage-Ia ovarian cancer after conservative surgical treatment and chemotherapy]. 61 54
15738608 2004
40
Human chorionic gonadotropin isoforms in the diagnosis of ectopic pregnancy. 54 61
14633876 2003
41
Implantation-dependent expression of trophinin by maternal fallopian tube epithelia during tubal pregnancies: possible role of human chorionic gonadotrophin on ectopic pregnancy. 54 61
14633596 2003
42
[Management of non-surgical treatment of ectopic pregnancy]. 54 61
14699320 2003
43
Glycodelin serum levels in women with ectopic pregnancy. 61 54
12781411 2003
44
Early and late half-life of human chorionic gonadotropin as a predictor of persistent trophoblast after laparoscopic conservative surgery for tubal pregnancy. 54 61
12780426 2003
45
Heterophile antibody blocking agent to confirm false positive serum human chorionic gonadotropin assay. 54 61
12738132 2003
46
Human chorionic gonadotropin level as a predictor of trophoblastic infiltration into the tubal wall in ectopic pregnancy: a blinded study. 54 61
12749441 2003
47
Persistent ectopic pregnancy after linear salpingotomy: a non-predictable complication to conservative surgery for tubal gestation. 54 61
12421174 2002
48
Presumed diagnosis of ectopic pregnancy. 54 61
12220770 2002
49
Symptom-free women at increased risk of ectopic pregnancy: should we screen? 61 54
12190842 2002
50
Human chorionic gonadotropin patterns after a single dose of methotrexate for ectopic pregnancy. 61 54
11750970 2002
Sources

Variations for Ectopic Pregnancy

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Sources

Expression for Ectopic Pregnancy

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Search GEO for disease gene expression data for Ectopic Pregnancy.
Sources

Pathways for Ectopic Pregnancy

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Pathways related to Ectopic Pregnancy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
NF-KappaB Family Pathway 63
Show member pathways
 12.17 TLR2 PROK1 PGF IL1B GNRH1
2
Rheumatoid arthritis 36
11.47 VEGFA TLR2 IL1B
3
Interleukin-4 and 13 signaling 65
11.31 VEGFA MUC1 LIF IL1B
4
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 65
Show member pathways
 10.89 VEGFA CGB5 CGB3 CGA
5
G-protein signaling_Rap2B regulation pathway 22
10.67 PROK1 PGF LIF IL1B GNRH1
6
VEGF binds to VEGFR leading to receptor dimerization 65
Show member pathways
 10.61 VEGFA PGF
7
Hormone ligand-binding receptors 65
10.37 GNRH1 CGA
Sources

GO Terms for Ectopic Pregnancy

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Cellular components related to Ectopic Pregnancy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 VEGFA PGF PAPPA MUC1 LIF IL1B
2 extracellular region GO:0005576 9.5 VEGFA PROK1 PGF PAPPA PAEP MUC1

Biological processes related to Ectopic Pregnancy according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 10.01 TLR2 PAEP IL1B CGB7 CGB5 CGB3
2 G protein-coupled receptor signaling pathway GO:0007186 9.97 PROKR2 PROK1 GNRH1 CNR1 CGB7 CGB5
3 signal transduction GO:0007165 9.9 VEGFA TLR2 PROKR2 PGF IL1B GNRH1
4 cytokine-mediated signaling pathway GO:0019221 9.88 VEGFA MUC1 LIF IL1B
5 positive regulation of cell proliferation GO:0008284 9.88 VEGFA PROK1 PGF LIF IL1B CGA
6 response to lipopolysaccharide GO:0032496 9.83 TLR2 IL1B GNRH1 CNR1
7 positive regulation of angiogenesis GO:0045766 9.76 VEGFA PGF IL1B ADAM12
8 female pregnancy GO:0007565 9.74 PGF PAPPA GNRH1
9 hormone-mediated signaling pathway GO:0009755 9.69 CGB7 CGB5 CGB3
10 cellular response to hormone stimulus GO:0032870 9.65 PROKR2 PGF CGA
11 positive regulation of interleukin-6 secretion GO:2000778 9.61 TLR2 PAEP IL1B
12 vascular endothelial growth factor signaling pathway GO:0038084 9.59 VEGFA PGF
13 induction of positive chemotaxis GO:0050930 9.58 VEGFA PGF
14 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.56 PAEP IL1B
15 positive regulation of mast cell chemotaxis GO:0060754 9.55 VEGFA PGF
16 female gamete generation GO:0007292 9.5 CGB7 CGB5 CGB3
17 positive regulation of fever generation GO:0031622 9.49 IL1B CNR1
18 peptide hormone processing GO:0016486 9.43 CGB5 CGB3 CGA
19 positive regulation of cell division GO:0051781 9.26 VEGFA PROK1 PGF IL1B
20 cell-cell signaling GO:0007267 9.1 PGF IL1B GNRH1 CGB7 CGB5 CGB3

Molecular functions related to Ectopic Pregnancy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 VEGFA PROK1 PGF LIF
2 vascular endothelial growth factor receptor binding GO:0005172 9.16 VEGFA PGF
3 hormone activity GO:0005179 9.02 GNRH1 CGB7 CGB5 CGB3 CGA
Sources

Sources for Ectopic Pregnancy

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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