MCID: ECT005
MIFTS: 44

Ectropion

Categories: Eye diseases, Fetal diseases, Rare diseases, Skin diseases
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Aliases & Classifications for Ectropion

MalaCards integrated aliases for Ectropion:

Name: Ectropion 11 53 43 14 75 33
Ectropion of Eyelid 11 31 33
Everted Margin 11 33
Unspecified Ectropion of Unspecified Eye 33
Eversion of the Eyelid 33
Eyelashes Turned out 33
Eyelid Turned out 33
Eyelid Everted 33

Classifications:



External Ids:

Disease Ontology 11 DOID:1570
ICD9CM 34 374.1
MeSH 43 D004483
SNOMED-CT 68 155178000
ICD10 31 H02.1
UMLS 71 C0013592

Summaries for Ectropion

MalaCards based summary: Ectropion, also known as ectropion of eyelid, is related to blepharocheilodontic syndrome 1 and cicatricial ectropion. An important gene associated with Ectropion is TGM1 (Transglutaminase 1), and among its related pathways/superpathways are Metabolism and Adhesion. The drugs Racepinephrine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and cervix, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia: 75 Ectropion is a medical condition in which the lower eyelid turns outwards. It is one of the notable... more...

Related Diseases for Ectropion

Diseases in the Ectropion family:

Rare Disorder with Ectropion Congenital Ectropion
Secondary Ectropion

Diseases related to Ectropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 347)
# Related Disease Score Top Affiliating Genes
1 blepharocheilodontic syndrome 1 32.7 CTNND1 CDH1
2 cicatricial ectropion 32.2 TGM1 NIPAL4 ABCA12
3 euryblepharon 31.9 CTNND1 CDH1
4 neu-laxova syndrome 1 31.8 PSAT1 PHGDH
5 ichthyosis, congenital, autosomal recessive 3 30.9 ALOXE3 ALOX12B
6 ichthyosis, congenital, autosomal recessive 4a 30.9 TGM1 PNPLA1 NIPAL4 CYP4F22 ALOX12B ABCA12
7 intraocular pressure quantitative trait locus 30.7 PAX6 CYP1B1 CRYAA
8 keratitis, hereditary 30.5 PAX6 CYP1B1 CRYAA
9 distichiasis 30.5 CTNND1 CDH1
10 glaucoma 3, primary congenital, a 30.5 PAX6 NF1 CYP1B1
11 ichthyosis, congenital, autosomal recessive 2 30.3 PNPLA1 NIPAL4 ALOXE3 ALOX12B ABHD5
12 ichthyosis, congenital, autosomal recessive 1 30.2 TGM1 PNPLA1 NIPAL4 CYP4F22 CERS3 ALOXE3
13 juvenile glaucoma 30.2 PAX6 CYP1B1 CRYAA
14 axenfeld-rieger syndrome 30.1 PAX6 CYP1B1 CRYAA
15 ichthyosis, congenital, autosomal recessive 7 29.9 TGM1 PNPLA1 NIPAL4 CYP4F22 CERS3 ALOXE3
16 aniridia 1 29.8 PAX6 CYP1B1 CRYAA
17 anterior segment dysgenesis 29.8 PAX6 CYP1B1 CRYAA
18 ichthyosis, congenital, autosomal recessive 4b 29.8 TGM1 PNPLA1 NIPAL4 CYP4F22 CERS3 ALOXE3
19 eye disease 29.6 PAX6 NF1 CYP1B1 CRYAA CDH1
20 glaucoma, primary open angle 29.6 PAX6 CYP1B1 CRYAA
21 autosomal recessive congenital ichthyosis 29.3 TGM1 PNPLA1 NIPAL4 MBTPS2 CYP4F22 CERS3
22 skin disease 28.8 TGM1 PNPLA1 NF1 FERMT1 CERS3 CDH1
23 ichthyosis vulgaris 28.6 TGM1 PNPLA1 NIPAL4 CYP4F22 ALOXE3 ALOX12B
24 ichthyosis 28.2 TGM1 PSAT1 PNPLA1 PHGDH NIPAL4 MBTPS2
25 barber-say syndrome 11.5
26 ichthyosis alopecia eclabion ectropion intellectual disability 11.4
27 congenital ectropion 11.3
28 senile ectropion 11.3
29 mandibulofacial dysostosis with macroblepharon and macrostomia 11.3
30 congenital ectropion uveae 11.2
31 isolated congenital ectropion 11.2
32 mechanical ectropion 11.2
33 spastic ectropion 11.1
34 postaxial acrofacial dysostosis 11.0
35 facial clefting, oblique, 1 11.0
36 ichthyosis, congenital, autosomal recessive 11 11.0
37 sezary's disease 11.0
38 secondary ectropion 11.0
39 eversion of lacrimal punctum 11.0
40 ichthyosis with alopecia, eclabium, ectropion, and mental retardation 10.9
41 ichthyosis with confetti 10.9
42 jones hersh yusk syndrome 10.9
43 rare disorder with ectropion 10.9
44 corneal dystrophy, posterior polymorphous, 1 10.8
45 chromosome xq25 duplication syndrome 10.8
46 keratosis follicularis spinulosa decalvans, x-linked 10.8
47 ichthyosis, congenital, autosomal recessive 5 10.8
48 ichthyosis, congenital, autosomal recessive 6 10.8
49 ichthyosis, congenital, autosomal recessive 8 10.8
50 ichthyosis, congenital, autosomal recessive 9 10.8

Graphical network of the top 20 diseases related to Ectropion:



Diseases related to Ectropion

Symptoms & Phenotypes for Ectropion

MGI Mouse Phenotypes related to Ectropion:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.3 ABCA12 ABHD5 ALOX12B ALOXE3 CDH1 CERS3
2 growth/size/body region MP:0005378 10.22 ABCA12 ABHD5 ALOXE3 CDH1 CERS3 CTNND1
3 neoplasm MP:0002006 9.95 CDH1 CTNND1 CYP1B1 NF1 PAX6 PHGDH
4 cellular MP:0005384 9.9 ABCA12 ABHD5 CDH1 CRYAA CTNND1 FERMT1
5 mortality/aging MP:0010768 9.89 ABCA12 ABHD5 ALOX12B ALOXE3 CDH1 CERS3
6 craniofacial MP:0005382 9.86 ABCA12 CTNND1 NF1 PAX6 PHGDH PNPLA1
7 integument MP:0010771 9.5 ABCA12 ABHD5 ALOX12B ALOXE3 CDH1 CERS3

Drugs & Therapeutics for Ectropion

Drugs for Ectropion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Racepinephrine Approved, Vet_approved Phase 4 51-43-4, 329-65-7 838 5816
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3
Brimonidine Tartrate Phase 4 70359-46-5
4 Neurotransmitter Agents Phase 4
5 Adrenergic alpha-Agonists Phase 4
6 Adrenergic Agonists Phase 4
7 Adrenergic Agents Phase 4
8 Epinephryl borate Phase 4
9 Antihypertensive Agents Phase 4
10 Anticoagulants Phase 4
11 Hemostatics Phase 4
12
Fluorouracil Approved Phase 2 51-21-8 3385
13 Antimetabolites Phase 2
14 Immunosuppressive Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Intraoperative Brimonidine for Hemostasis During Eyelid Surgery Recruiting NCT05480098 Phase 4 Brimonidine Topical
2 Post-Marketing Clinical Follow-up (PMCF) Study in Ophthalmic Surgery to Evaluate the Safety and Efficacy of Novosyn® Quick Suture Material. A Multicenter Randomized, Active-controlled, Double-blinded, Prospective, Observational Study. Withdrawn NCT02761083 Phase 4
3 Hyaluronic Acid Gels for Lower Lid Retraction Withdrawn NCT01838252 Phase 4
4 A Prospective, Randomized, Double-blinded Comparison of the Use of 5-fluorouracil Versus Placebo in Periocular Full Thickness Skin Grafts. Completed NCT02705352 Phase 2 5-Fluorouracil
5 Telemedicine Follow-up for Routine, Low-Risk Oculoplastic Surgery Unknown status NCT04235803
6 Assessment of Changes of Periocular Skin Sensation Following Eyelid and Ocular Surface Surgeries Unknown status NCT02638610
7 Comparison Between Two Surgical Methods for Eyelid Ectropion: Tarsal Strip Alone Versus Tarsal Strip With Punctoplasty (Three Snips With or Without Diamond-shaped Resection) Completed NCT02893813
8 Lacrimal Drainage Resistance Study Completed NCT01766232

Search NIH Clinical Center for Ectropion

Cochrane evidence based reviews: ectropion

Genetic Tests for Ectropion

Anatomical Context for Ectropion

Organs/tissues related to Ectropion:

MalaCards : Eye, Skin, Cervix, Endothelial, Bone, Breast, Retina

Publications for Ectropion

Articles related to Ectropion:

(show top 50) (show all 2007)
# Title Authors PMID Year
1
Novel transglutaminase-1 mutations and genotype-phenotype investigations of 104 patients with autosomal recessive congenital ichthyosis in the USA. 53 62
18948357 2009
2
Conjunctivitis associated with capecitabine treatment in a patient with colon cancer: The importance on educating patients into identifying adverse reactions. 62
35369809 2022
3
Association of topical glaucoma medications with lacrimal drainage obstruction and eyelid malposition. 62
36473973 2022
4
Autologous fat grafting for the correction of cicatricial ectropion. 62
36270948 2022
5
Absorbable Suture Anchor Technique: A Method for Postblepharoplasty Lower Eyelid Ectropion Treatment. 62
36155941 2022
6
Tarsal Ectropion Repair With Modified Bick Eyelid Tightening and Inverting Sutures. 62
36136735 2022
7
ImageJ assessment of double-frequency YAG laser efficacy in treatment of mild lower eyelid ectropion with punctal eversion. 62
36441347 2022
8
Evaluation of virtual surgical planning and three-dimensional configurations for reconstruction of maxillary defects using the fibula free flap. 62
36102527 2022
9
Biplanar-pivoted V-Y Flap for Reconstruction of Medial Canthal Defects. 62
35550475 2022
10
Longitudinal trends in volume of oculoplastic procedures without ACGME minimum requirements among United States ophthalmology residents: an ACGME case log analysis. 62
36398702 2022
11
Intraorbıtal Fixatıon Midface Lıft. 62
36342769 2022
12
Successful treatment of severe pityriasis rubra pilaris with secukinumab in a 3-year-old boy. 62
35906074 2022
13
Toward Universal Eye Health Coverage-Key Outcomes of the World Health Organization Package of Eye Care Interventions: A Systematic Review. 62
36394836 2022
14
A case of neurofibromatosis type 1 and unilateral glaucoma with ectropion uveae. 62
35722677 2022
15
Prevalence and Characteristics of Dupilumab-Induced Ocular Surface Disease in Adults With Atopic Dermatitis. 62
34843182 2022
16
Dupilumab-associated ectropion and punctal stenosis treated with tacrolimus ointment (0.03%) in a 15-year-old girl. 62
36113697 2022
17
Pathogenic Novel Heterozygous Variant c.1076c>T p. (Ser359Phe) chr1: 120512166 in NOTCH2 Gene, Type 2 Alagille Syndrome Causing Neonatal Cholestasis: A Case Report. 62
36201396 2022
18
Effects of salpingitis simulation on the morphology and expression of inflammatory-related genes of oviduct in laying hens. 62
36335735 2022
19
Ectropion of odontogenic origin. 62
36373261 2022
20
Involutional ectropion: etiological factors and therapeutic management. 62
36053479 2022
21
Lateral Tarsal Strip Complications With and Without Conjunctiva Stripping. 62
35323138 2022
22
Tarsoconjunctival-Skin Flap as Another Option in Correcting Ectropion for Oro-Ocular Cleft Reconstruction: Report of 2 Cases. 62
34410197 2022
23
Simplified technique for lateral canthal tendon canthopexy. 62
36018130 2022
24
Evaluation of the postoperative course of East Asian eyelid reconstruction with free tarsoconjunctival graft transplantation: A Japanese single-centre retrospective study. 62
35591860 2022
25
Characteristics and Outcomes of Glaucoma Associated With Congenital Ectropion Uvea. 62
35358486 2022
26
Severe Bilateral Ectropion in Lamellar Ichthyosis: A Case Report. 62
35989479 2022
27
Ageing increases risk of lower eyelid malposition after primary orbital fracture reconstruction. 62
36244868 2022
28
Does cataract surgery in patients with concurrent lower lid malposition increase the risk of postoperative endophthalmitis? 62
34058139 2022
29
Midterm results of conjunctival reconstruction with buccal mucosa and amniotic membrane after resecting ocular surface squamous neoplasia of the fornix. 62
35940212 2022
30
Lower Eyelid Sling for Primary and Revision Correction of Paralytic Lagophthalmos. 62
35969387 2022
31
[The prevention and therapy of corneal ulcers in patients with large-area thermal burns]. 62
35959603 2022
32
Evaluation of Bicanalicular Nasolacrimal Duct Intubation as an Adjunct in Surgical Ectropion Correction. 62
36013518 2022
33
Surgical Correction of Lower Lid Epiblepharon With Skin-Only Resection Using a Novel Design. 62
34611103 2022
34
Punctal Stenosis Associated with Topical Netarsudil Use. 62
35231471 2022
35
Medial Canthus Reconstruction with the Paramedian Forehead Flap. 62
35919689 2022
36
Neonatal-Onset Congenital Ectropion Uveae May Be Caused by a Distinct CYP1B1 Pathologic Variant. 62
35085548 2022
37
Auricular Cartilage Graft for Lengthening Levator Muscle Aponeurosis With Ectropion Correction for Paralytic Lagophthalmos. 62
35788264 2022
38
Commentary on: Auricular Cartilage Graft for Lengthening Levator Muscle Aponeurosis With Ectropion Correction for Paralytic Lagophthalmos. 62
35880799 2022
39
Cheek-midface lifting with lateral canthoplasy for the repair of complex iatrogenic lower eyelid ectropion. 62
34414803 2022
40
Factors leading to dissemination of cutaneous anthrax: an international ID-IRI study. 62
36193102 2022
41
Clinical Manifestations in Patients Wearing Ocular Prostheses. 62
34775443 2022
42
Elastoma of the Orbit: A Case Report. 62
35797673 2022
43
Glaucoma management in congenital ectropion uveae: Surgical outcomes from a large tertiary referral center in South India. 62
35769044 2022
44
Using A modified quickert procedure combined with prolapsed fat and preseptal orbicularis muscle removal to correct involutional lower eyelid entropion in Asians. 62
35667643 2022
45
[Reconstruction of facial skin defects by the V-Y subcutaneous pedicle flap]. 62
35725315 2022
46
The Prevalence of Ocular Manifestations in the Various Types of Common Skin Disorders at Tertiary Hospital in Ahmedabad, India. 62
35844330 2022
47
Management of Harlequin Ichthyosis: A Brief Review of the Recent Literature. 62
35740830 2022
48
Evaluation of 5-aminolevulinic acid-mediated photodynamic therapy on cervical low-grade squamous intraepithelial lesions with high-risk HPV infection. 62
35288319 2022
49
Review of Eye Injuries Associated With Dermatologic Laser Treatment. 62
35333214 2022
50
Correction of severe medial ectropion using a novel osseous fixation technique. 62
35576365 2022

Variations for Ectropion

Expression for Ectropion

Search GEO for disease gene expression data for Ectropion.

Pathways for Ectropion

Pathways related to Ectropion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.73 PSAT1 PHGDH MBTPS2 CYP4F22 CYP1B1 CERS3
2 11.42 FERMT1 CTNND1 CDH1
3 10.62 ALOXE3 ALOX12B
4 10.21 CTNND1 CDH1

GO Terms for Ectropion

Biological processes related to Ectropion according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 lipid homeostasis GO:0055088 9.95 PNPLA1 ABHD5 ABCA12
2 lipid metabolic process GO:0006629 9.86 PNPLA1 MBTPS2 CYP4F22 CYP1B1 CERS3 ALOXE3
3 fatty acid metabolic process GO:0006631 9.85 CYP1B1 ALOXE3 ALOX12B ABHD5
4 arachidonic acid metabolic process GO:0019369 9.85 CYP1B1 ALOXE3 ALOX12B
5 lipoxygenase pathway GO:0019372 9.83 ALOXE3 ALOX12B
6 negative regulation of neuroblast proliferation GO:0007406 9.81 PAX6 NF1
7 hepoxilin biosynthetic process GO:0051122 9.8 ALOXE3 ALOX12B
8 sphingolipid metabolic process GO:0006665 9.8 CERS3 ALOXE3 ALOX12B
9 L-serine biosynthetic process GO:0006564 9.73 PSAT1 PHGDH
10 establishment of skin barrier GO:0061436 9.7 PNPLA1 ALOXE3 ALOX12B ABCA12
11 icosanoid metabolic process GO:0006690 9.62 ALOX12B ALOXE3 CYP4F22
12 keratinocyte differentiation GO:0030216 9.56 TGM1 PNPLA1 PAX6 CERS3 ABCA12
13 ceramide biosynthetic process GO:0046513 9.32 PNPLA1 CYP4F22 CERS3 ALOXE3 ALOX12B

Molecular functions related to Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.55 PHGDH CYP4F22 CYP1B1 ALOXE3 ALOX12B
2 hydroperoxy icosatetraenoate dehydratase activity GO:0106256 9.26 CYP1B1 ALOXE3
3 iron ion binding GO:0005506 9.23 CYP4F22 CYP1B1 ALOXE3 ALOX12B

Sources for Ectropion

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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