Ectropion disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Ectropion, also known as ectropion of eyelid, is related to blepharocheilodontic syndrome 1 and cicatricial ectropion. An important gene associated with Ectropion is TGM1 (Transglutaminase 1), and among its related pathways/superpathways are Metabolism and Adhesion. The drugs Racepinephrine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and cervix, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia: ⁷⁵ Ectropion is a medical condition in which the lower eyelid turns outwards. It is one of the notable... more...

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Related Diseases for Ectropion

Diseases in the Ectropion family:

Rare Disorder with Ectropion	Congenital Ectropion
Secondary Ectropion

Diseases related to Ectropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 347)

#	Related Disease	Score	Top Affiliating Genes
1	blepharocheilodontic syndrome 1	32.7	CTNND1 CDH1
2	cicatricial ectropion	32.2	TGM1 NIPAL4 ABCA12
3	euryblepharon	31.9	CTNND1 CDH1
4	neu-laxova syndrome 1	31.8	PSAT1 PHGDH
5	ichthyosis, congenital, autosomal recessive 3	30.9	ALOXE3 ALOX12B
6	ichthyosis, congenital, autosomal recessive 4a	30.9	TGM1 PNPLA1 NIPAL4 CYP4F22 ALOX12B ABCA12
7	intraocular pressure quantitative trait locus	30.7	PAX6 CYP1B1 CRYAA
8	keratitis, hereditary	30.5	PAX6 CYP1B1 CRYAA
9	distichiasis	30.5	CTNND1 CDH1
10	glaucoma 3, primary congenital, a	30.5	PAX6 NF1 CYP1B1
11	ichthyosis, congenital, autosomal recessive 2	30.3	PNPLA1 NIPAL4 ALOXE3 ALOX12B ABHD5
12	ichthyosis, congenital, autosomal recessive 1	30.2	TGM1 PNPLA1 NIPAL4 CYP4F22 CERS3 ALOXE3
13	juvenile glaucoma	30.2	PAX6 CYP1B1 CRYAA
14	axenfeld-rieger syndrome	30.1	PAX6 CYP1B1 CRYAA
15	ichthyosis, congenital, autosomal recessive 7	29.9	TGM1 PNPLA1 NIPAL4 CYP4F22 CERS3 ALOXE3
16	aniridia 1	29.8	PAX6 CYP1B1 CRYAA
17	anterior segment dysgenesis	29.8	PAX6 CYP1B1 CRYAA
18	ichthyosis, congenital, autosomal recessive 4b	29.8	TGM1 PNPLA1 NIPAL4 CYP4F22 CERS3 ALOXE3
19	eye disease	29.6	PAX6 NF1 CYP1B1 CRYAA CDH1
20	glaucoma, primary open angle	29.6	PAX6 CYP1B1 CRYAA
21	autosomal recessive congenital ichthyosis	29.3	TGM1 PNPLA1 NIPAL4 MBTPS2 CYP4F22 CERS3
22	skin disease	28.8	TGM1 PNPLA1 NF1 FERMT1 CERS3 CDH1
23	ichthyosis vulgaris	28.6	TGM1 PNPLA1 NIPAL4 CYP4F22 ALOXE3 ALOX12B
24	ichthyosis	28.2	TGM1 PSAT1 PNPLA1 PHGDH NIPAL4 MBTPS2
25	barber-say syndrome	11.5
26	ichthyosis alopecia eclabion ectropion intellectual disability	11.4
27	congenital ectropion	11.3
28	senile ectropion	11.3
29	mandibulofacial dysostosis with macroblepharon and macrostomia	11.3
30	congenital ectropion uveae	11.2
31	isolated congenital ectropion	11.2
32	mechanical ectropion	11.2
33	spastic ectropion	11.1
34	postaxial acrofacial dysostosis	11.0
35	facial clefting, oblique, 1	11.0
36	ichthyosis, congenital, autosomal recessive 11	11.0
37	sezary's disease	11.0
38	secondary ectropion	11.0
39	eversion of lacrimal punctum	11.0
40	ichthyosis with alopecia, eclabium, ectropion, and mental retardation	10.9
41	ichthyosis with confetti	10.9
42	jones hersh yusk syndrome	10.9
43	rare disorder with ectropion	10.9
44	corneal dystrophy, posterior polymorphous, 1	10.8
45	chromosome xq25 duplication syndrome	10.8
46	keratosis follicularis spinulosa decalvans, x-linked	10.8
47	ichthyosis, congenital, autosomal recessive 5	10.8
48	ichthyosis, congenital, autosomal recessive 6	10.8
49	ichthyosis, congenital, autosomal recessive 8	10.8
50	ichthyosis, congenital, autosomal recessive 9	10.8

Graphical network of the top 20 diseases related to Ectropion:

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Symptoms & Phenotypes for Ectropion

MGI Mouse Phenotypes related to Ectropion:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.3	ABCA12 ABHD5 ALOX12B ALOXE3 CDH1 CERS3
2	growth/size/body region	MP:0005378	10.22	ABCA12 ABHD5 ALOXE3 CDH1 CERS3 CTNND1
3	neoplasm	MP:0002006	9.95	CDH1 CTNND1 CYP1B1 NF1 PAX6 PHGDH
4	cellular	MP:0005384	9.9	ABCA12 ABHD5 CDH1 CRYAA CTNND1 FERMT1
5	mortality/aging	MP:0010768	9.89	ABCA12 ABHD5 ALOX12B ALOXE3 CDH1 CERS3
6	craniofacial	MP:0005382	9.86	ABCA12 CTNND1 NF1 PAX6 PHGDH PNPLA1
7	integument	MP:0010771	9.5	ABCA12 ABHD5 ALOX12B ALOXE3 CDH1 CERS3

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Drugs & Therapeutics for Ectropion

Drugs for Ectropion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Racepinephrine

Approved, Vet_approved

Phase 4

51-43-4, 329-65-7

838 5816

Synonyms:

(−)-(R)-epinephrine

(-)-(R)-Epinephrine

(-)-3,4-Dihydroxy-a-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-a-[(methylamino)methyl]-benzyl alcohol

(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol

(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-alpha-[(methylamino)methyl]-benzyl alcohol

(-)-3,4-DIHYDROXY-ALPHA-[(METHYLAMINO)METHYL]BENZYL ALCOHOL(-)-3,4-DIHYDROXY-ALPHA-[(METHYLAMINO)METHYL]-BENZYL ALCOHOL

(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol

(−)-3,4-dihydroxy-α-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-α-((methylamino)methyl)benzyl alcohol

(-)-Adrenaline

(−)-ADRENALINE

(-)-Epinephrine

(+-)-Adrenaline

(+-)-Epinephrine

(R)-(-)-Adnephrine

(R)-(-)-Adrenaline

(R)-(−)-ADRENALINE

(R)-(-)-Epinephrine

(R)-(-)-Epirenamine

(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

(R)-Adrenaline

(R)-Epinephrine

2-(Methylamino)-1-(3,4-dihydroxyphenyl)ethanol

4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol

4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

4-[(1R)-1-HYDROXY-2-METHYLAMINOETHYL]BENZENE-1,2-DIOL

4-[(1R)-1-HYDROXY-2-METHYLAMINO-ETHYL]BENZENE-1,2-DIOL

4-[(1R)-1-HYDROXY-2-METHYLAMINO-ETHYL]PYROCATECHOL

Acetate, epinephrine

Adnephrine

ADREN CO

ADRENACLICK

Adrenal

Adrenalin

Adrenaline

Adrénaline

Adrenaline acid tartrate

Adrenaline bitartrate

Adrenaline hydrochloride

Adrenaline hydrochloride, racemic mixture

Adrenaline, racemic

Adrenaline, racemic mixture

adrenaline|epinephrine

Adrenine

Adrin

Allergan brand OF adrenaline hydrochloride

ANA-GUARD

Ana-kit

ANAPEN

ANAPHYLACTIC SHOCK DRUG KIT

ASMA-VYDRIN

ASTHMAHALER

Auvi-Q

Bird brand OF racepinefrine hydrochloride

Bosmin

Bronkaid mist

BROVON

Chelafrin

DL-Adrenaline

EMERADE

EPI E Z PEN JR

Epifrin

Epiglaufrin

Epinefrin

Epinefrina

Epinephran

Epinephrin

EPINEPHRINE

Epinephrine acetate

Epinephrine bitartrate

EPINEPHRINE HCL

Epinephrine hydrochloride

Epinephrine hydrochloride, racemic mixture

Epinephrine hydrogen tartrate

Epinephrine racemic

Epinephrine, racemic

Epinephrine, racemic mixture

Epinephrinum

Epipen

EPIPEN E Z PEN

Epipen JR

EPIPEN JR.

Epirenan

Epitrate

Eppy

Exadrin

Glauposine

GPPE INH SOLN

Hemisine

Hemostasin

Hemostatin

Hydrochloride, racepinephrine

Hypernephrin

Isoptoepinal

JEXT

L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol

L-Adrenaline

L-DETHYLAMINOETHANOLCATECHOL

L-Epinephrine

L-Epirenamine

Levoepinephrine

LEVO-METHYLAMINOETHANOLCATECHOL

Levorenen

Levorenin

Levorenine

Levoreninum

L-Methylaminoethanolcatechol

Lyodrin

Lyophrin

Medihaler-epi

Methylarterenol

Micronefrin

Micronephrine

Mixture adrenaline, racemic

Mixture epinephrine, racemic

Mucidrina

Nephridine

Nieraline

NSC-62786

Paranephrin

Primatene

Primatene mist

R-(-)-Epinephrine

Racemic adrenaline

Racemic epinephrine

Racemic mixture adrenaline

Racemic mixture epinephrine

Racepinefrina

Racepinefrine

Racepinefrinum

Racepinephrine

Racepinephrine hydrochloride

Renaglandin

Renaleptine

Renalina

Renoform

Renostypticin

Renostyptin

RIDDOBRON

RIDDOFAN

RYBARVIN

Scurenaline

Simplene

SOLN MADE TO RYBARVIN FOR

Styptirenal

Supracapsulin

Supranephrane

Suprarenaline

Suprarenin

Surrenine

Sus-phrine

SUS-PHRINE SULFITE FREE

SUS-PHRINE SULFITE-FREE

SYMJEPI

Takamina

TWINJECT

TWINJECT 0.15

TWINJECT 0.3

Vaponefrin

Vasoconstrictine

Vasotonin

2

Lidocaine

Approved, Vet_approved

Phase 4

137-58-6

3676

3

Brimonidine Tartrate

Phase 4

70359-46-5

4

Neurotransmitter Agents

Phase 4

5

Adrenergic alpha-Agonists

Phase 4

6

Adrenergic Agonists

Phase 4

7

Adrenergic Agents

Phase 4

8

Epinephryl borate

Phase 4

9

Antihypertensive Agents

Phase 4

10

Anticoagulants

Phase 4

11

Hemostatics

Phase 4

12

Fluorouracil

Approved

Phase 2

51-21-8

3385

13

Antimetabolites

Phase 2

14

Immunosuppressive Agents

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Efficacy of Intraoperative Brimonidine for Hemostasis During Eyelid Surgery	Recruiting	NCT05480098	Phase 4	Brimonidine Topical
2	Post-Marketing Clinical Follow-up (PMCF) Study in Ophthalmic Surgery to Evaluate the Safety and Efficacy of Novosyn® Quick Suture Material. A Multicenter Randomized, Active-controlled, Double-blinded, Prospective, Observational Study.	Withdrawn	NCT02761083	Phase 4
3	Hyaluronic Acid Gels for Lower Lid Retraction	Withdrawn	NCT01838252	Phase 4
4	A Prospective, Randomized, Double-blinded Comparison of the Use of 5-fluorouracil Versus Placebo in Periocular Full Thickness Skin Grafts.	Completed	NCT02705352	Phase 2	5-Fluorouracil
5	Telemedicine Follow-up for Routine, Low-Risk Oculoplastic Surgery	Unknown status	NCT04235803
6	Assessment of Changes of Periocular Skin Sensation Following Eyelid and Ocular Surface Surgeries	Unknown status	NCT02638610
7	Comparison Between Two Surgical Methods for Eyelid Ectropion: Tarsal Strip Alone Versus Tarsal Strip With Punctoplasty (Three Snips With or Without Diamond-shaped Resection)	Completed	NCT02893813
8	Lacrimal Drainage Resistance Study	Completed	NCT01766232

Search NIH Clinical Center for Ectropion

Cochrane evidence based reviews: ectropion

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Genetic Tests for Ectropion

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Anatomical Context for Ectropion

Organs/tissues related to Ectropion:

MalaCards : Eye, Skin, Cervix, Endothelial, Bone, Breast, Retina

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Publications for Ectropion

Articles related to Ectropion:

(show top 50) (show all 2007)

#	Title	Authors	PMID	Year
1	Novel transglutaminase-1 mutations and genotype-phenotype investigations of 104 patients with autosomal recessive congenital ichthyosis in the USA. ⁵³ ⁶²	Farasat S...Toro JR	18948357	2009
2	Conjunctivitis associated with capecitabine treatment in a patient with colon cancer: The importance on educating patients into identifying adverse reactions. ⁶²	Bello Crespo M...Gioseffi HA	35369809	2022
3	Association of topical glaucoma medications with lacrimal drainage obstruction and eyelid malposition. ⁶²	Quinn MP...Campbell RJ	36473973	2022
4	Autologous fat grafting for the correction of cicatricial ectropion. ⁶²	Tanwar V...Bajaj MS	36270948	2022
5	Absorbable Suture Anchor Technique: A Method for Postblepharoplasty Lower Eyelid Ectropion Treatment. ⁶²	Li H...Zhao Y	36155941	2022
6	Tarsal Ectropion Repair With Modified Bick Eyelid Tightening and Inverting Sutures. ⁶²	Wang D...Shinder R	36136735	2022
7	ImageJ assessment of double-frequency YAG laser efficacy in treatment of mild lower eyelid ectropion with punctal eversion. ⁶²	Salamah M...Albialy HA	36441347	2022
8	Evaluation of virtual surgical planning and three-dimensional configurations for reconstruction of maxillary defects using the fibula free flap. ⁶²	Verdoy SB...Segu JOB	36102527	2022
9	Biplanar-pivoted V-Y Flap for Reconstruction of Medial Canthal Defects. ⁶²	Karthik N...Perry JD	35550475	2022
10	Longitudinal trends in volume of oculoplastic procedures without ACGME minimum requirements among United States ophthalmology residents: an ACGME case log analysis. ⁶²	Kim E...Migliori M	36398702	2022
11	Intraorbıtal Fixatıon Midface Lıft. ⁶²	Bitik O	36342769	2022
12	Successful treatment of severe pityriasis rubra pilaris with secukinumab in a 3-year-old boy. ⁶²	Xu YH...Shi JQ	35906074	2022
13	Toward Universal Eye Health Coverage-Key Outcomes of the World Health Organization Package of Eye Care Interventions: A Systematic Review. ⁶²	Keel S...Package of Eye Care Interventions Development Group	36394836	2022
14	A case of neurofibromatosis type 1 and unilateral glaucoma with ectropion uveae. ⁶²	Thananjeyan AL...Grigg JRB	35722677	2022
15	Prevalence and Characteristics of Dupilumab-Induced Ocular Surface Disease in Adults With Atopic Dermatitis. ⁶²	Felfeli T...Chan CC	34843182	2022
16	Dupilumab-associated ectropion and punctal stenosis treated with tacrolimus ointment (0.03%) in a 15-year-old girl. ⁶²	Sivanandam A...Areaux RG	36113697	2022
17	Pathogenic Novel Heterozygous Variant c.1076c>T p. (Ser359Phe) chr1: 120512166 in NOTCH2 Gene, Type 2 Alagille Syndrome Causing Neonatal Cholestasis: A Case Report. ⁶²	Uddin MS...Al Hatlani MM	36201396	2022
18	Effects of salpingitis simulation on the morphology and expression of inflammatory-related genes of oviduct in laying hens. ⁶²	Li LL...Ding BY	36335735	2022
19	Ectropion of odontogenic origin. ⁶²	Kim Y...Kim SW	36373261	2022
20	Involutional ectropion: etiological factors and therapeutic management. ⁶²	AlHarthi AS	36053479	2022
21	Lateral Tarsal Strip Complications With and Without Conjunctiva Stripping. ⁶²	Clauss KD...Lee WW	35323138	2022
22	Tarsoconjunctival-Skin Flap as Another Option in Correcting Ectropion for Oro-Ocular Cleft Reconstruction: Report of 2 Cases. ⁶²	Hutagalung MR...Zarasade L	34410197	2022
23	Simplified technique for lateral canthal tendon canthopexy. ⁶²	Qureshi Z...Demirci H	36018130	2022
24	Evaluation of the postoperative course of East Asian eyelid reconstruction with free tarsoconjunctival graft transplantation: A Japanese single-centre retrospective study. ⁶²	Ominato J...Fukuchi T	35591860	2022
25	Characteristics and Outcomes of Glaucoma Associated With Congenital Ectropion Uvea. ⁶²	Jacobson A...Bohnsack BL	35358486	2022
26	Severe Bilateral Ectropion in Lamellar Ichthyosis: A Case Report. ⁶²	Moustaine MO...Chabbab FZ	35989479	2022
27	Ageing increases risk of lower eyelid malposition after primary orbital fracture reconstruction. ⁶²	Rajantie H...Thoren H	36244868	2022
28	Does cataract surgery in patients with concurrent lower lid malposition increase the risk of postoperative endophthalmitis? ⁶²	Yarmak P...Rocha G	34058139	2022
29	Midterm results of conjunctival reconstruction with buccal mucosa and amniotic membrane after resecting ocular surface squamous neoplasia of the fornix. ⁶²	Rahal A...Westekemper H	35940212	2022
30	Lower Eyelid Sling for Primary and Revision Correction of Paralytic Lagophthalmos. ⁶²	Bartholomew RA...Jowett N	35969387	2022
31	[The prevention and therapy of corneal ulcers in patients with large-area thermal burns]. ⁶²	Dong Y...Huang YF	35959603	2022
32	Evaluation of Bicanalicular Nasolacrimal Duct Intubation as an Adjunct in Surgical Ectropion Correction. ⁶²	Papazoglou A...Enz TJ	36013518	2022
33	Surgical Correction of Lower Lid Epiblepharon With Skin-Only Resection Using a Novel Design. ⁶²	Chae W...Kim H	34611103	2022
34	Punctal Stenosis Associated with Topical Netarsudil Use. ⁶²	Meirick TM...Chen PP	35231471	2022
35	Medial Canthus Reconstruction with the Paramedian Forehead Flap. ⁶²	Gupta R...Chaiyasate K	35919689	2022
36	Neonatal-Onset Congenital Ectropion Uveae May Be Caused by a Distinct CYP1B1 Pathologic Variant. ⁶²	Kaushik S...Pandav SS	35085548	2022
37	Auricular Cartilage Graft for Lengthening Levator Muscle Aponeurosis With Ectropion Correction for Paralytic Lagophthalmos. ⁶²	Lowndes Correa Francalacci R...Aboudib JHDC	35788264	2022
38	Commentary on: Auricular Cartilage Graft for Lengthening Levator Muscle Aponeurosis With Ectropion Correction for Paralytic Lagophthalmos. ⁶²	Putterman AM	35880799	2022
39	Cheek-midface lifting with lateral canthoplasy for the repair of complex iatrogenic lower eyelid ectropion. ⁶²	Kopecky A...Heindl LM	34414803	2022
40	Factors leading to dissemination of cutaneous anthrax: an international ID-IRI study. ⁶²	Elbahr US...Giammanco A	36193102	2022
41	Clinical Manifestations in Patients Wearing Ocular Prostheses. ⁶²	Kim J...Baek S	34775443	2022
42	Elastoma of the Orbit: A Case Report. ⁶²	Komzak K...Goold L	35797673	2022
43	Glaucoma management in congenital ectropion uveae: Surgical outcomes from a large tertiary referral center in South India. ⁶²	Mandal AK...Gothwal VK	35769044	2022
44	Using A modified quickert procedure combined with prolapsed fat and preseptal orbicularis muscle removal to correct involutional lower eyelid entropion in Asians. ⁶²	Chen CY...Tsai YJ	35667643	2022
45	[Reconstruction of facial skin defects by the V-Y subcutaneous pedicle flap]. ⁶²	Wei MZ...Li X	35725315	2022
46	The Prevalence of Ocular Manifestations in the Various Types of Common Skin Disorders at Tertiary Hospital in Ahmedabad, India. ⁶²	Damor VM...Ipli SG	35844330	2022
47	Management of Harlequin Ichthyosis: A Brief Review of the Recent Literature. ⁶²	Tsivilika M...Papamitsou T	35740830	2022
48	Evaluation of 5-aminolevulinic acid-mediated photodynamic therapy on cervical low-grade squamous intraepithelial lesions with high-risk HPV infection. ⁶²	Wang X...Xu W	35288319	2022
49	Review of Eye Injuries Associated With Dermatologic Laser Treatment. ⁶²	Flegel L...Richer V	35333214	2022
50	Correction of severe medial ectropion using a novel osseous fixation technique. ⁶²	Vrcek I...Nakra T	35576365	2022

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Genes for Ectropion

Genes related to Ectropion (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	TGM1	Transglutaminase 1	Protein Coding	22.14	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18948357
2	ABCA12	ATP Binding Cassette Subfamily A Member 12	Protein Coding	15.76	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
3	PAX6	Paired Box 6	Protein Coding	13.05	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
4	CYP1B1	Cytochrome P450 Family 1 Subfamily B Member 1	Protein Coding	12.96	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
5	NF1	Neurofibromin 1	Protein Coding	12.27	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
6	MBTPS2	Membrane Bound Transcription Factor Peptidase, Site 2	Protein Coding	12.14	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
7	CTNND1	Catenin Delta 1	Protein Coding	11.62	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
8	TWIST2	Twist Family BHLH Transcription Factor 2	Protein Coding	11.36	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
9	PSAT1	Phosphoserine Aminotransferase 1	Protein Coding	10.24	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
10	CDH1	Cadherin 1	Protein Coding	7.98	GeneCards inferred via : Disorders (show sections)
11	NIPAL4	NIPA Like Domain Containing 4	Protein Coding	7.64	DISEASES inferred ¹⁴
12	ALOX12B	Arachidonate 12-Lipoxygenase, 12R Type	Protein Coding	7.33	DISEASES inferred ¹⁴
13	CYP4F22	Cytochrome P450 Family 4 Subfamily F Member 22	Protein Coding	7.31	DISEASES inferred ¹⁴
14	PNPLA1	Patatin Like Phospholipase Domain Containing 1	Protein Coding	7.29	DISEASES inferred ¹⁴
15	ALOXE3	Arachidonate Lipoxygenase 3	Protein Coding	7.23	DISEASES inferred ¹⁴
16	PHGDH	Phosphoglycerate Dehydrogenase	Protein Coding	7.04	GeneCards inferred via : Disorders (show sections)
17	CERS3	Ceramide Synthase 3	Protein Coding	6.5	DISEASES inferred ¹⁴
18	FERMT1	FERM Domain Containing Kindlin 1	Protein Coding	6.26	DISEASES inferred ¹⁴
19	ABHD5	Abhydrolase Domain Containing 5, Lysophosphatidic Acid Acyltransferase	Protein Coding	6.05	DISEASES inferred ¹⁴
20	CRYAA	Crystallin Alpha A	Protein Coding	5.94	DISEASES inferred ¹⁴ ¹⁴

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Variations for Ectropion

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Expression for Ectropion

Search GEO for disease gene expression data for Ectropion.

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Pathways for Ectropion

Pathways related to Ectropion according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism ⁶⁶ Show member pathways Metabolism of lipids ⁶⁶	12.73	PSAT1 PHGDH MBTPS2 CYP4F22 CYP1B1 CERS3
2	Adhesion ³	11.42	FERMT1 CTNND1 CDH1
3	Prostaglandin 2 biosynthesis and metabolism FM ²²	10.62	ALOXE3 ALOX12B
4	E-cadherin signaling in keratinocytes ⁶¹	10.21	CTNND1 CDH1

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GO Terms for Ectropion

Biological processes related to Ectropion according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	lipid homeostasis	GO:0055088	9.95	PNPLA1 ABHD5 ABCA12
2	lipid metabolic process	GO:0006629	9.86	PNPLA1 MBTPS2 CYP4F22 CYP1B1 CERS3 ALOXE3
3	fatty acid metabolic process	GO:0006631	9.85	CYP1B1 ALOXE3 ALOX12B ABHD5
4	arachidonic acid metabolic process	GO:0019369	9.85	CYP1B1 ALOXE3 ALOX12B
5	lipoxygenase pathway	GO:0019372	9.83	ALOXE3 ALOX12B
6	negative regulation of neuroblast proliferation	GO:0007406	9.81	PAX6 NF1
7	hepoxilin biosynthetic process	GO:0051122	9.8	ALOXE3 ALOX12B
8	sphingolipid metabolic process	GO:0006665	9.8	CERS3 ALOXE3 ALOX12B
9	L-serine biosynthetic process	GO:0006564	9.73	PSAT1 PHGDH
10	establishment of skin barrier	GO:0061436	9.7	PNPLA1 ALOXE3 ALOX12B ABCA12
11	icosanoid metabolic process	GO:0006690	9.62	ALOX12B ALOXE3 CYP4F22
12	keratinocyte differentiation	GO:0030216	9.56	TGM1 PNPLA1 PAX6 CERS3 ABCA12
13	ceramide biosynthetic process	GO:0046513	9.32	PNPLA1 CYP4F22 CERS3 ALOXE3 ALOX12B

Molecular functions related to Ectropion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidoreductase activity	GO:0016491	9.55	PHGDH CYP4F22 CYP1B1 ALOXE3 ALOX12B
2	hydroperoxy icosatetraenoate dehydratase activity	GO:0106256	9.26	CYP1B1 ALOXE3
3	iron ion binding	GO:0005506	9.23	CYP4F22 CYP1B1 ALOXE3 ALOX12B

Sources

Sources for Ectropion

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ECT005 MIFTS: 44	Ectropion Categories: Eye diseases, Fetal diseases, Rare diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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