Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: ECT005
MIFTS: 46

Ectropion

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Ectropion

About this section

MalaCards integrated aliases for Ectropion:

Name: Ectropion 12 29 55 44 15
Ectropion of Eyelid 12
Everted Margin 12

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1570
ICD9CM 35 374.1 374.10
MeSH 44 D004483
SNOMED-CT 68 62909004
UMLS 73 C0013592
Sources

Summaries for Ectropion

About this section
MalaCards based summary : Ectropion, also known as ectropion of eyelid, is related to blepharocheilodontic syndrome 1 and ichthyosis, congenital, autosomal recessive 4b. An important gene associated with Ectropion is TGM1 (Transglutaminase 1), and among its related pathways/superpathways are Adherens junction and FGF signaling pathway. The drugs Immunologic Factors and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and cervix, and related phenotypes are cellular and behavior/neurological

Wikipedia : 76 Ectropion is a medical condition in which the lower eyelid turns outwards. It is one of the notable... more...

Sources

Related Diseases for Ectropion

About this section

Diseases related to Ectropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 blepharocheilodontic syndrome 1 33.2 CDH1 CTNND1
2 ichthyosis, congenital, autosomal recessive 4b 32.3 ABCA12 TGM1
3 ichthyosis, congenital, autosomal recessive 4a 31.7 ABCA12 TGM1
4 ichthyosis, congenital, autosomal recessive 1 31.7 ABCA12 TGM1
5 euryblepharon 31.0 CDH1 CTNND1
6 ichthyosis 30.5 ABCA12 MBTPS2 TGM1
7 distichiasis 30.2 CDH1 CTNND1
8 cicatricial ectropion 12.3
9 congenital ectropion uveae 12.3
10 ichthyosis alopecia eclabion ectropion mental retardation 12.3
11 senile ectropion 12.3
12 mechanical ectropion 12.2
13 spastic ectropion 12.2
14 isolated congenital ectropion 12.1
15 barber-say syndrome 12.1
16 ichthyosis with alopecia, eclabium, ectropion, and mental retardation 12.0
17 autosomal recessive congenital ichthyosis 11.3
18 mandibulofacial dysostosis with macroblepharon and macrostomia 11.2
19 neu-laxova syndrome 1 11.1
20 jones hersh yusk syndrome 11.0
21 corneal dystrophy, posterior polymorphous, 1 10.9
22 ichthyosis, congenital, autosomal recessive 2 10.9
23 keratosis follicularis spinulosa decalvans, x-linked 10.9
24 ichthyosis, congenital, autosomal recessive 11 10.9
25 ichthyosis, congenital, autosomal recessive 5 10.9
26 ichthyosis, congenital, autosomal recessive 3 10.9
27 ichthyosis, congenital, autosomal recessive 6 10.9
28 fontaine progeroid syndrome 10.9
29 ichthyosis, congenital, autosomal recessive 8 10.9
30 ichthyosis, congenital, autosomal recessive 7 10.9
31 ichthyosis, congenital, autosomal recessive 9 10.9
32 ichthyosis, congenital, autosomal recessive 10 10.9
33 neu-laxova syndrome 2 10.9
34 blepharocheilodontic syndrome 2 10.9
35 sezary's disease 10.9
36 oculomaxillofacial dysostosis 10.9
37 entropion 10.6
38 ptosis 10.1
39 lagophthalmos 10.1
40 facial paralysis 10.1
41 senile entropion 10.1
42 pyoderma 10.1
43 pyoderma gangrenosum 10.1
44 eyelid disease 10.0 ABCA12 TGM1
45 basal cell carcinoma 1 10.0
46 burns 10.0
47 ichthyosis lamellar 1 10.0
48 juvenile glaucoma 10.0
49 basal cell carcinoma 10.0
50 hypertrichosis 10.0

Graphical network of the top 20 diseases related to Ectropion:



Diseases related to Ectropion
Sources

Symptoms & Phenotypes for Ectropion

About this section

MGI Mouse Phenotypes related to Ectropion:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 ABCA12 CDH1 CTNND1 KMT2D NF1 PAX6
2 behavior/neurological MP:0005386 9.99 ABCA12 KMT2D NF1 PAX6 TGM1 TWIST2
3 cardiovascular system MP:0005385 9.97 ABCA12 CDH1 KMT2D NF1 PAX6 TWIST2
4 growth/size/body region MP:0005378 9.95 ABCA12 CDH1 KMT2D NF1 PAX6 TGM1
5 homeostasis/metabolism MP:0005376 9.87 ABCA12 CDH1 KMT2D NF1 PAX6 TGM1
6 craniofacial MP:0005382 9.85 ABCA12 KMT2D NF1 PAX6 TWIST2
7 digestive/alimentary MP:0005381 9.83 CDH1 CTNND1 NF1 PAX6 TWIST2
8 integument MP:0010771 9.8 ABCA12 CDH1 CTNND1 NF1 PAX6 TGM1
9 mortality/aging MP:0010768 9.76 ABCA12 CDH1 CTNND1 KMT2D NF1 PAX6
10 hearing/vestibular/ear MP:0005377 9.67 KMT2D NF1 PAX6 TWIST2
11 neoplasm MP:0002006 9.35 CDH1 CTNND1 KMT2D NF1 PAX6
12 respiratory system MP:0005388 9.02 ABCA12 KMT2D NF1 PAX6 TWIST2
Sources

Drugs & Therapeutics for Ectropion

About this section

Drugs for Ectropion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 4,Phase 2
2
Fluorouracil Approved Phase 2 51-21-8 3385
3 Antimetabolites, Antineoplastic Phase 2
4 Antimetabolites Phase 2
5 Immunosuppressive Agents Phase 2
6
Iodine Approved, Investigational Not Applicable 7553-56-2 807
7
acetic acid Approved Not Applicable 64-19-7 176
8
Ethanol Approved Not Applicable 64-17-5 702
9
Retinol acetate Not Applicable 127-47-9 10245972
10 cadexomer iodine Not Applicable

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Hyaluronic Acid Gels for Lower Lid Retraction Withdrawn NCT01838252 Phase 4
2 PMCF-study Using Novosyn® Quick Suture Material in Ophthalmic Surgery Withdrawn NCT02761083 Phase 4
3 Treatment of the Recessive Nonbullous Congenital Ichthyosis by the Epigallocatechine Cutaneous Unknown status NCT01222000 Phase 3 apply VEREGEN ® 10 % on a randomized area and the moisturizing cream of the other side;apply VEREGEN ® 10 % on a randomized area and the moisturizing cream of the other side
4 5-fluorouracil Versus Placebo in Periocular Full Thickness Skin Grafts Recruiting NCT02705352 Phase 2 5-Fluorouracil
5 A Safety, Efficacy and Systemic Exposure Study of CD5789 Cream in Adults and Adolescents With Lamellar Ichthyosis Not yet recruiting NCT03738800 Phase 2 CD5789 Cream 200 µg/g;CD5789 Cream 100 µg/g;CD5789 Cream Vehicle
6 Assessment of Changes of Periocular Skin Sensation Following Eyelid and Ocular Surface Surgeries Unknown status NCT02638610 Not Applicable
7 Comparison Between Two Surgical Methods for Eyelid Ectropion: Tarsal Strip Alone Versus Tarsal Strip With Punctoplasty (Three Snips With or Without Diamond-shaped Resection) Completed NCT02893813
8 Lacrimal Drainage Resistance Study Completed NCT01766232
9 Minimally Invasive Holmium:YAG Laser Blepharoplasty Completed NCT00842764 Not Applicable
10 Comparison Between iLuxâ„¢ and LipiFlow® in the Treatment of Meibomian Gland Dysfunction Completed NCT03055832 Not Applicable
11 Diagnosis of Cervical Lesions in Women With Unhealthy Looking Cervix Recruiting NCT03150745 Not Applicable
12 Spanish Registry of Mohs Surgery Recruiting NCT02310503

Search NIH Clinical Center for Ectropion

Cochrane evidence based reviews: ectropion

Sources

Genetic Tests for Ectropion

About this section

Genetic tests related to Ectropion:

# Genetic test Affiliating Genes
1 Ectropion 29
Sources

Anatomical Context for Ectropion

About this section

MalaCards organs/tissues related to Ectropion:

41
Skin, Eye, Cervix, Testes, Lung, Bone
Sources

Publications for Ectropion

About this section

Articles related to Ectropion:

(show top 50) (show all 487)
# Title Authors Year
1
The vertical orbicularis oculi muscle turn-over procedure for the correction of paralytic ectropion of the lower eyelid. ( 29506332 )
2018
2
Severe ectropion in lamellar ichthyosis managed medically with oral acitretin. ( 29334142 )
2018
3
Angle closure glaucoma in congenital ectropion uvea. ( 29552671 )
2018
4
Reversible cicatricial ectropion associated with EGFR inhibitors. ( 29336655 )
2018
5
Vector analysis of changes in corneal astigmatism following lateral tarsal strip procedure in patients with involutional ectropion or entropion. ( 30054850 )
2018
6
Association of Blepharitis and Ectropion With Tumor Necrosis Factor α Inhibitor Treatment in Crohn Disease. ( 30419086 )
2018
7
Apremilast Use in a Case of Cicatricial Ectropion Secondary to Severe Lamellar Ichthyosis. ( 29346172 )
2018
8
Cicatricial ectropion surgery: a prospective study of long-term symptom control, patient satisfaction and anatomical success. ( 29920894 )
2018
9
Correction of cicatricial ectropion using non-ablative fractional laser resurfacing. ( 30056585 )
2018
10
Efficacy of lateral eyelid-block excision with canthoplasty and full-thickness skin grafting in lower eyelid cicatricial ectropion. ( 30390376 )
2018
11
Bilateral, presumed congenital ectropion uveae in a patient with pathologic myopia. ( 30128365 )
2018
12
Correction of cicatricial and involutional lower eyelid ectropion with hyaluronic acid. ( 30094302 )
2018
13
Lateral tarsal strip versus lateral tarsal strip with three-snip punctoplasty for managing epiphora in involutional ectropion. ( 30217604 )
2018
14
Case report of Wolfe grafting for the management of bilateral cicatricial eyelid ectropion following severe burn injuries. ( 30237879 )
2018
15
The Use of a Double Suture and Conjunctival Cuts in the Lateral Tarsal Strip: A New Approach to Involutional Ectropion. ( 30320676 )
2018
16
Modification of the Lazy-T Procedure for Correction of Punctal Ectropion. ( 30444779 )
2018
17
Algorithm for the management of ectropion through medial and lateral canthopexy. ( 30466232 )
2018
18
A quantitative analysis of factors influencing lower lid retraction and involutional ectropion. ( 30467002 )
2018
19
Entropion and ectropion repair: a snapshot of surgical practice in the United Kingdom. ( 29053043 )
2017
20
Upper eyelid ectropion repair. ( 28928260 )
2017
21
Congenital ectropion uveae with glaucoma: a case report. ( 29027062 )
2017
22
Acquired ectropion uveae and secondary glaucoma due to trauma: report of 3 cases. ( 27768224 )
2017
23
Ectropion, Lower Eyelid Reconstruction ( 29262075 )
2017
24
Congenital upper eyelids ectropion in Down's syndrome. ( 28194320 )
2017
25
Is it safe to use N-acetylcysteineA in the treatment of bilateralA ectropion on collodion baby? ( 28083950 )
2017
26
Vertical-to-Horizontal Rotational Myocutaneous Flap for Repairing Cicatricial Lower Lid Ectropion: A Novel Surgical Technique. ( 29181406 )
2017
27
Punctal Ectropion repair using the Raus-Garito clamp. ( 28853961 )
2017
28
"The influence of orbital vector on involutional entropion and ectropion". ( 28853964 )
2017
29
Cervical Ectropion May Be a Cause of Desquamative Inflammatory Vaginitis. ( 28460993 )
2017
30
Ectropion ( 28722958 )
2017
31
Ectropion Improvement with Topical Tazarotene in Children with Lamellar Ichthyosis. ( 28815772 )
2017
32
Chromomycosis, an unusual cause of cicatricial ectropion: a case report. ( 28380102 )
2017
33
Cicatricial ectropion in a patient treated with dupilumab. ( 29260094 )
2017
34
Cicatricial Ectropion Secondary to Graft-Versus-Host Disease. ( 28746254 )
2017
35
Newly identified paired box 6 mutation of variant familial aniridia: Congenital iris ectropion with foveal hypoplasia. ( 28300742 )
2017
36
The Lateral Tarsal Strip for Paralytic Ectropion in Patients with Leprosy. ( 29200763 )
2017
37
Comparison of Polypropylene Sling with Combined Transconjunctival Retractor Plication and Lateral Tarsal Strip for Correction of Involutional Lower Eye Lid Ectropion. ( 29081868 )
2017
38
Subcuticular Suture Technique: Alternative to Frost Suture to Prevent Ectropion After Transcutaneous Incision of Lower Eyelid. ( 29038637 )
2017
39
Ablative Fractional Laser Resurfacing With Laser-Assisted Delivery of 5-Fluorouracil for the Treatment of Cicatricial Ectropion and Periocular Scarring. ( 28658179 )
2017
40
Recurrent Lower Eyelid Ectropion After Graft Surgery Using Autogenous Palmaris Longus Tendon. ( 29227410 )
2017
41
Long term follow up of mucous membrane grafting for cicatricial ectropion in Ichthyosis: A case report. ( 28314226 )
2017
42
Congenital Ectropion Uveae with Glaucoma: A Case Report. ( 28764212 )
2017
43
Ectropion in Facial Tissue Expansion in the Pediatric Population: Incidence, Risk Factors, and Treatment Options. ( 27529153 )
2016
44
Cicatricial Ectropion With Topical 5% Fluorouracil Cream. ( 27191780 )
2016
45
Ectropion and Conjunctival Mass in a Patient with Primary Bilateral Conjunctival Amyloidosis. ( 27974983 )
2016
46
Facial Pyoderma Gangrenosum Presenting With Cranial Nerve VII Palsy and Cicatricial Ectropion. ( 27893584 )
2016
47
Surgical Microanatomy of Lower Eyelid Tarsal Ectropion Repair With a Putterman Ptosis Clamp. ( 27429229 )
2016
48
Modified lateral tarsal strip for involutional entropion and ectropion surgery. ( 27817116 )
2016
49
Lipograft in cicatricial ectropion. ( 27842016 )
2016
50
"Boomerang Technique: " Simple Excision With Periosteal Suspension for Correction of Mild-to-Moderate Cicatricial Ectropion. ( 26859652 )
2016
Sources

Variations for Ectropion

About this section
Sources

Expression for Ectropion

About this section
Search GEO for disease gene expression data for Ectropion.
Sources

Pathways for Ectropion

About this section

Pathways related to Ectropion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Adherens junction 37
11.26 CDH1 CTNND1
2
FGF signaling pathway 1
11.04 CDH1 CTNND1
3
Arf6 trafficking events 1
10.97 CDH1 CTNND1
4
Cell adhesion_Cadherin-mediated cell adhesion 22
10.86 CDH1 CTNND1
5
Stabilization and expansion of the E-cadherin adherens junction 1
10.76 CDH1 CTNND1
6
E-cadherin signaling in the nascent adherens junction 1
10.47 CDH1 CTNND1
7
E-cadherin signaling in keratinocytes 1
9.9 CDH1 CTNND1
Sources

GO Terms for Ectropion

About this section

Cellular components related to Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 catenin complex GO:0016342 8.62 CDH1 CTNND1

Biological processes related to Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 brain development GO:0007420 9.43 CTNND1 NF1 PAX6
2 cell-cell junction assembly GO:0007043 9.37 CDH1 CTNND1
3 adherens junction organization GO:0034332 9.32 CDH1 CTNND1
4 pituitary gland development GO:0021983 9.16 CDH1 PAX6
5 entry of bacterium into host cell GO:0035635 8.96 CDH1 CTNND1
6 keratinocyte differentiation GO:0030216 8.8 ABCA12 PAX6 TGM1

Molecular functions related to Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion molecule binding GO:0050839 8.62 CDH1 CTNND1
Sources

Sources for Ectropion

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....