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MCID: ECT005
MIFTS: 46

Ectropion

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Ectropion

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MalaCards integrated aliases for Ectropion:

Name: Ectropion 12 29 55 44 15
Ectropion of Eyelid 12
Everted Margin 12

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1570
ICD9CM 35 374.1 374.10
MeSH 44 D004483
UMLS 73 C0013592
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Summaries for Ectropion

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MalaCards based summary : Ectropion, also known as ectropion of eyelid, is related to blepharocheilodontic syndrome 1 and ichthyosis, congenital, autosomal recessive 4b. An important gene associated with Ectropion is TGM1 (Transglutaminase 1), and among its related pathways/superpathways are Adherens junction and FGF signaling pathway. The drugs Fluorouracil and Antimetabolites have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and cervix, and related phenotypes are growth/size/body region and craniofacial

Wikipedia : 76 Ectropion is a medical condition in which the lower eyelid turns outwards. It is one of the notable... more...

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Related Diseases for Ectropion

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Diseases related to Ectropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
# Related Disease Score Top Affiliating Genes
1 blepharocheilodontic syndrome 1 33.4 CDH1 CTNND1
2 ichthyosis, congenital, autosomal recessive 4b 32.1 ABCA12 TGM1
3 ichthyosis, congenital, autosomal recessive 4a 31.6 ABCA12 TGM1
4 ichthyosis, congenital, autosomal recessive 1 31.4 ABCA12 TGM1
5 euryblepharon 31.2 CDH1 CTNND1
6 distichiasis 30.3 CDH1 CTNND1
7 ichthyosis 29.7 ABCA12 MBTPS2 TGM1
8 cicatricial ectropion 12.1
9 congenital ectropion uveae 12.1
10 ichthyosis alopecia eclabion ectropion mental retardation 12.1
11 senile ectropion 12.1
12 mechanical ectropion 12.1
13 spastic ectropion 12.1
14 isolated congenital ectropion 12.0
15 barber-say syndrome 11.9
16 ichthyosis with alopecia, eclabium, ectropion, and mental retardation 11.9
17 congenital ichthyosiform erythroderma 11.2
18 mandibulofacial dysostosis with macroblepharon and macrostomia 11.1
19 neu-laxova syndrome 1 10.9
20 jones hersh yusk syndrome 10.9
21 corneal dystrophy, posterior polymorphous, 1 10.8
22 ichthyosis, congenital, autosomal recessive 2 10.8
23 keratosis follicularis spinulosa decalvans, x-linked 10.8
24 ichthyosis, congenital, autosomal recessive 11 10.8
25 ichthyosis, congenital, autosomal recessive 5 10.8
26 ichthyosis, congenital, autosomal recessive 3 10.8
27 ichthyosis, congenital, autosomal recessive 6 10.8
28 fontaine progeroid syndrome 10.8
29 ichthyosis, congenital, autosomal recessive 8 10.8
30 ichthyosis, congenital, autosomal recessive 7 10.8
31 ichthyosis, congenital, autosomal recessive 9 10.8
32 ichthyosis, congenital, autosomal recessive 10 10.8
33 neu-laxova syndrome 2 10.8
34 blepharocheilodontic syndrome 2 10.8
35 sezary's disease 10.8
36 entropion 10.4
37 cervicitis 10.2
38 eyelid disease 10.0 ABCA12 TGM1
39 burns 10.0
40 ptosis 10.0
41 lagophthalmos 10.0
42 facial paralysis 10.0
43 vaginitis 9.9
44 ichthyosis vulgaris 9.9 ABCA12 TGM1
45 mucositis 9.9
46 senile entropion 9.9
47 pyoderma 9.9
48 pyoderma gangrenosum 9.9
49 aging 9.8
50 basal cell carcinoma 1 9.8

Graphical network of the top 20 diseases related to Ectropion:



Diseases related to Ectropion
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Symptoms & Phenotypes for Ectropion

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MGI Mouse Phenotypes related to Ectropion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.87 PSAT1 ABCA12 TGM1 CDH1 TWIST2 NF1
2 craniofacial MP:0005382 9.8 PSAT1 ABCA12 TWIST2 NF1 PAX6
3 homeostasis/metabolism MP:0005376 9.8 PSAT1 ABCA12 TGM1 CDH1 TWIST2 NF1
4 digestive/alimentary MP:0005381 9.77 CDH1 TWIST2 CTNND1 NF1 PAX6
5 integument MP:0010771 9.7 ABCA12 TGM1 CDH1 TWIST2 CTNND1 NF1
6 mortality/aging MP:0010768 9.5 PAX6 ABCA12 TGM1 CDH1 TWIST2 CTNND1
7 neoplasm MP:0002006 8.92 PAX6 CDH1 CTNND1 NF1
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Drugs & Therapeutics for Ectropion

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Drugs for Ectropion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 2 51-21-8 3385
2 Antimetabolites Phase 2
3 Antimetabolites, Antineoplastic Phase 2
4 Immunosuppressive Agents Phase 2
5
Ethanol Approved Not Applicable 64-17-5 702
6
Iodine Approved, Investigational Not Applicable 7553-56-2 807
7
acetic acid Approved, Nutraceutical Not Applicable 64-19-7 176
8 cadexomer iodine Not Applicable
9
Retinol acetate Not Applicable 127-47-9 10245972

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Hyaluronic Acid Gels for Lower Lid Retraction Withdrawn NCT01838252 Phase 4
2 PMCF-study Using Novosyn® Quick Suture Material in Ophthalmic Surgery Withdrawn NCT02761083 Phase 4
3 Treatment of the Recessive Nonbullous Congenital Ichthyosis by the Epigallocatechine Cutaneous Unknown status NCT01222000 Phase 3 apply VEREGEN ® 10 % on a randomized area and the moisturizing cream of the other side;apply VEREGEN ® 10 % on a randomized area and the moisturizing cream of the other side
4 5-fluorouracil Versus Placebo in Periocular Full Thickness Skin Grafts Recruiting NCT02705352 Phase 2 5-Fluorouracil
5 Assessment of Changes of Periocular Skin Sensation Following Eyelid and Ocular Surface Surgeries Unknown status NCT02638610 Not Applicable
6 Comparison Between Two Surgical Methods for Eyelid Ectropion: Tarsal Strip Alone Versus Tarsal Strip With Punctoplasty (Three Snips With or Without Diamond-shaped Resection) Completed NCT02893813
7 Lacrimal Drainage Resistance Study Completed NCT01766232
8 Minimally Invasive Holmium:YAG Laser Blepharoplasty Completed NCT00842764 Not Applicable
9 Diagnosis of Cervical Lesions in Women With Unhealthy Looking Cervix Recruiting NCT03150745 Not Applicable
10 Spanish Registry of Mohs Surgery Recruiting NCT02310503

Search NIH Clinical Center for Ectropion

Cochrane evidence based reviews: ectropion

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Genetic Tests for Ectropion

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Genetic tests related to Ectropion:

# Genetic test Affiliating Genes
1 Ectropion 29
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Anatomical Context for Ectropion

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MalaCards organs/tissues related to Ectropion:

41
Skin, Eye, Cervix, Testes, Lung, Bone
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Publications for Ectropion

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Articles related to Ectropion:

(show top 50) (show all 463)
# Title Authors Year
1
The vertical orbicularis oculi muscle turn-over procedure for the correction of paralytic ectropion of the lower eyelid. ( 29506332 )
2018
2
Severe ectropion in lamellar ichthyosis managed medically with oral acitretin. ( 29334142 )
2018
3
Angle closure glaucoma in congenital ectropion uvea. ( 29552671 )
2018
4
Reversible cicatricial ectropion associated with EGFR inhibitors. ( 29336655 )
2018
5
Apremilast Use in a Case of Cicatricial Ectropion Secondary to Severe Lamellar Ichthyosis. ( 29346172 )
2018
6
Cicatricial ectropion surgery: a prospective study of long-term symptom control, patient satisfaction and anatomical success. ( 29920894 )
2018
7
Entropion and ectropion repair: a snapshot of surgical practice in the United Kingdom. ( 29053043 )
2017
8
Upper eyelid ectropion repair. ( 28928260 )
2017
9
Congenital ectropion uveae with glaucoma: a case report. ( 29027062 )
2017
10
Acquired ectropion uveae and secondary glaucoma due to trauma: report of 3 cases. ( 27768224 )
2017
11
Ectropion, Lower Eyelid Reconstruction ( 29262075 )
2017
12
Congenital upper eyelids ectropion in Down's syndrome. ( 28194320 )
2017
13
Is it safe to use N-acetylcysteineA in the treatment of bilateralA ectropion on collodion baby? ( 28083950 )
2017
14
Vertical-to-Horizontal Rotational Myocutaneous Flap for Repairing Cicatricial Lower Lid Ectropion: A Novel Surgical Technique. ( 29181406 )
2017
15
Punctal Ectropion repair using the Raus-Garito clamp. ( 28853961 )
2017
16
Cervical Ectropion May Be a Cause of Desquamative Inflammatory Vaginitis. ( 28460993 )
2017
17
Ectropion ( 28722958 )
2017
18
Ectropion Improvement with Topical Tazarotene in Children with Lamellar Ichthyosis. ( 28815772 )
2017
19
Chromomycosis, an unusual cause of cicatricial ectropion: a case report. ( 28380102 )
2017
20
Cicatricial ectropion in a patient treated with dupilumab. ( 29260094 )
2017
21
Cicatricial Ectropion Secondary to Graft-Versus-Host Disease. ( 28746254 )
2017
22
Newly identified paired box 6 mutation of variant familial aniridia: Congenital iris ectropion with foveal hypoplasia. ( 28300742 )
2017
23
The Lateral Tarsal Strip for Paralytic Ectropion in Patients with Leprosy. ( 29200763 )
2017
24
Comparison of Polypropylene Sling with Combined Transconjunctival Retractor Plication and Lateral Tarsal Strip for Correction of Involutional Lower Eye Lid Ectropion. ( 29081868 )
2017
25
Subcuticular Suture Technique: Alternative to Frost Suture to Prevent Ectropion After Transcutaneous Incision of Lower Eyelid. ( 29038637 )
2017
26
Ablative Fractional Laser Resurfacing With Laser-Assisted Delivery of 5-Fluorouracil for the Treatment of Cicatricial Ectropion and Periocular Scarring. ( 28658179 )
2017
27
Recurrent Lower Eyelid Ectropion After Graft Surgery Using Autogenous Palmaris Longus Tendon. ( 29227410 )
2017
28
Long term follow up of mucous membrane grafting for cicatricial ectropion in Ichthyosis: A case report. ( 28314226 )
2017
29
Congenital Ectropion Uveae with Glaucoma: A Case Report. ( 28764212 )
2017
30
Ectropion in Facial Tissue Expansion in the Pediatric Population: Incidence, Risk Factors, and Treatment Options. ( 27529153 )
2016
31
Cicatricial Ectropion With Topical 5% Fluorouracil Cream. ( 27191780 )
2016
32
Ectropion and Conjunctival Mass in a Patient with Primary Bilateral Conjunctival Amyloidosis. ( 27974983 )
2016
33
Facial Pyoderma Gangrenosum Presenting With Cranial Nerve VII Palsy and Cicatricial Ectropion. ( 27893584 )
2016
34
Surgical Microanatomy of Lower Eyelid Tarsal Ectropion Repair With a Putterman Ptosis Clamp. ( 27429229 )
2016
35
Modified lateral tarsal strip for involutional entropion and ectropion surgery. ( 27817116 )
2016
36
Lipograft in cicatricial ectropion. ( 27842016 )
2016
37
"Boomerang Technique: " Simple Excision With Periosteal Suspension for Correction of Mild-to-Moderate Cicatricial Ectropion. ( 26859652 )
2016
38
Primary Horizontal Closure With Suspension Sutures for Infraorbital Defects to Achieve Aesthetically Superior Closure and Prevent Ectropion. ( 27224889 )
2016
39
A young Botswana patient with congenital iris ectropion uvea. ( 28154731 )
2016
40
Transposed Corrugator Supercilii Muscle-Tendon Unit Flap for Contralateral Paralytic Medial Ectropion Repair. ( 26987020 )
2016
41
Tarsal Strip Versus Tarsal Belt in Ectropion Correction: A Statistical Evaluation. ( 27755408 )
2016
42
The prevalence of glaucoma in patients undergoing surgery for eyelid entropion or ectropion. ( 27785003 )
2016
43
Frangipane's Penitent's ectropion. ( 27986438 )
2016
44
Orbicularis Oculi Myocutaneous Flap for Upper Cicatricial Ectropion. ( 26674895 )
2016
45
Misdiagnosed Periocular Pyoderma Gangrenosum Requiring Ectropion Repair With Development of Second Lesion of Pyoderma Gangrenosum at Graft Site. ( 26934168 )
2016
46
Cicatricial ectropion secondary to psoriatic arthritis. ( 25810938 )
2015
47
Long-Term Outcome of Combined Lateral Tarsal Strip With Temporal Permanent Tarsorrhaphy for Correction of Paralytic Ectropion Caused By Facial Nerve Palsy. ( 26086924 )
2015
48
The hybrid approach for reconstruction of severely destructed lower eyelids: combination of skin grafting, temporary tarsorrhaphy, and autologous fat grafting for cicatricial ectropion after injection of commercial grade silicone. ( 25569426 )
2015
49
Re: "Lower eyelid involutional ectropion repair with lateral tarsal strip and internal retractor reattachment with full-thickness eyelid sutures". ( 25945875 )
2015
50
Full-Thickness Skin Graft as an Independent or Adjunctive Technique for Repair of Cicatricial Lower Eyelid Ectropion Secondary to Actinic Skin Changes. ( 26164158 )
2015
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Variations for Ectropion

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Expression for Ectropion

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Search GEO for disease gene expression data for Ectropion.
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Pathways for Ectropion

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Pathways related to Ectropion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Adherens junction 37
11.26 CDH1 CTNND1
2
FGF signaling pathway 1
11.04 CDH1 CTNND1
3
Arf6 trafficking events 1
10.97 CDH1 CTNND1
4
Cell adhesion_Cadherin-mediated cell adhesion 22
10.86 CDH1 CTNND1
5
Stabilization and expansion of the E-cadherin adherens junction 1
10.76 CDH1 CTNND1
6
E-cadherin signaling in the nascent adherens junction 1
10.47 CDH1 CTNND1
7
E-cadherin signaling in keratinocytes 1
9.9 CDH1 CTNND1
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GO Terms for Ectropion

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Cellular components related to Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.23 ABCA12 CDH1 CTNND1 MBTPS2 NF1 PAX6

Biological processes related to Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 brain development GO:0007420 9.43 CTNND1 NF1 PAX6
2 adherens junction organization GO:0034332 9.32 CDH1 CTNND1
3 pituitary gland development GO:0021983 9.16 CDH1 PAX6
4 entry of bacterium into host cell GO:0035635 8.96 CDH1 CTNND1
5 keratinocyte differentiation GO:0030216 8.8 ABCA12 PAX6 TGM1

Molecular functions related to Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion molecule binding GO:0050839 8.62 CDH1 CTNND1
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Sources for Ectropion

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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