Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: ECT005
MIFTS: 45

Ectropion

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Ectropion

About this section

MalaCards integrated aliases for Ectropion:

Name: Ectropion 12 56 45 15
Ectropion of Eyelid 12
Everted Margin 12

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:1570
ICD9CM 36 374.1 374.10
MeSH 45 D004483
SNOMED-CT 69 62909004
UMLS 74 C0013592
Sources

Summaries for Ectropion

About this section
MalaCards based summary : Ectropion, also known as ectropion of eyelid, is related to blepharocheilodontic syndrome 1 and ichthyosis, congenital, autosomal recessive 4b. An important gene associated with Ectropion is TGM1 (Transglutaminase 1), and among its related pathways/superpathways are Ras signaling pathway and Adherens junction. The drugs Immunologic Factors and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and eye, and related phenotypes are cellular and growth/size/body region

Wikipedia : 77 Ectropion is a medical condition in which the lower eyelid turns outwards. It is one of the notable... more...

Sources

Related Diseases for Ectropion

About this section

Diseases related to Ectropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)
# Related Disease Score Top Affiliating Genes
1 blepharocheilodontic syndrome 1 33.3 CDH1 CTNND1
2 ichthyosis, congenital, autosomal recessive 4b 32.2 ABCA12 TGM1
3 ichthyosis, congenital, autosomal recessive 4a 31.7 ABCA12 TGM1
4 ichthyosis, congenital, autosomal recessive 1 31.3 ABCA12 TGM1
5 euryblepharon 31.2 CDH1 CTNND1
6 ichthyosis 30.4 ABCA12 MBTPS2 TGM1
7 distichiasis 30.2 CDH1 CTNND1
8 senile ectropion 12.3
9 cicatricial ectropion 12.3
10 ichthyosis alopecia eclabion ectropion mental retardation 12.3
11 congenital ectropion uveae 12.3
12 mechanical ectropion 12.3
13 spastic ectropion 12.3
14 isolated congenital ectropion 12.2
15 barber-say syndrome 12.1
16 ichthyosis with alopecia, eclabium, ectropion, and mental retardation 12.1
17 autosomal recessive congenital ichthyosis 11.4
18 mandibulofacial dysostosis with macroblepharon and macrostomia 11.3
19 neu-laxova syndrome 1 11.1
20 jones hersh yusk syndrome 11.1
21 corneal dystrophy, posterior polymorphous, 1 11.0
22 ichthyosis, congenital, autosomal recessive 2 11.0
23 keratosis follicularis spinulosa decalvans, x-linked 11.0
24 ichthyosis, congenital, autosomal recessive 11 11.0
25 ichthyosis, congenital, autosomal recessive 5 11.0
26 ichthyosis, congenital, autosomal recessive 3 11.0
27 ichthyosis, congenital, autosomal recessive 6 11.0
28 fontaine progeroid syndrome 11.0
29 ichthyosis, congenital, autosomal recessive 8 11.0
30 ichthyosis, congenital, autosomal recessive 7 11.0
31 ichthyosis, congenital, autosomal recessive 9 11.0
32 ichthyosis, congenital, autosomal recessive 10 11.0
33 neu-laxova syndrome 2 11.0
34 blepharocheilodontic syndrome 2 11.0
35 sezary's disease 11.0
36 oculomaxillofacial dysostosis 11.0
37 entropion 10.6
38 ptosis 10.3
39 senile entropion 10.2
40 facial paralysis 10.2
41 lagophthalmos 10.2
42 macrostomia, isolated 10.1
43 burns 10.1
44 pyoderma 10.1
45 pyoderma gangrenosum 10.1
46 basal cell carcinoma 1 10.0
47 ichthyosis lamellar 1 10.0
48 juvenile glaucoma 10.0
49 basal cell carcinoma 10.0
50 hypertrichosis 10.0

Graphical network of the top 20 diseases related to Ectropion:



Diseases related to Ectropion
Sources

Symptoms & Phenotypes for Ectropion

About this section

MGI Mouse Phenotypes related to Ectropion:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.95 ABCA12 CDH1 CTNND1 NF1 PAX6 PHGDH
2 growth/size/body region MP:0005378 9.87 ABCA12 CDH1 NF1 PAX6 PHGDH TGM1
3 homeostasis/metabolism MP:0005376 9.8 ABCA12 CDH1 NF1 PAX6 PHGDH TGM1
4 digestive/alimentary MP:0005381 9.77 CDH1 CTNND1 NF1 PAX6 TWIST2
5 integument MP:0010771 9.7 ABCA12 CDH1 CTNND1 NF1 PAX6 TGM1
6 mortality/aging MP:0010768 9.56 ABCA12 CDH1 CTNND1 NF1 PAX6 PHGDH
7 neoplasm MP:0002006 9.02 CDH1 CTNND1 NF1 PAX6 PHGDH
Sources

Drugs & Therapeutics for Ectropion

About this section

Drugs for Ectropion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 4,Phase 2
2
Fluorouracil Approved Phase 2 51-21-8 3385
3 Trifarotene Investigational Phase 2 895542-09-3
4 Dermatologic Agents Phase 2
5 Antimetabolites, Antineoplastic Phase 2
6 Immunosuppressive Agents Phase 2
7 Antimetabolites Phase 2
8
acetic acid Approved Not Applicable 64-19-7 176
9
Iodine Approved, Investigational Not Applicable 7553-56-2 807
10
Ethanol Approved Not Applicable 64-17-5 702
11 cadexomer iodine Not Applicable
12
Retinol acetate Not Applicable 127-47-9 10245972

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Hyaluronic Acid Gels for Lower Lid Retraction Withdrawn NCT01838252 Phase 4
2 PMCF-study Using Novosyn® Quick Suture Material in Ophthalmic Surgery Withdrawn NCT02761083 Phase 4
3 Treatment of the Recessive Nonbullous Congenital Ichthyosis by the Epigallocatechine Cutaneous Unknown status NCT01222000 Phase 3 apply VEREGEN ® 10 % on a randomized area and the moisturizing cream of the other side;apply VEREGEN ® 10 % on a randomized area and the moisturizing cream of the other side
4 A Safety, Efficacy and Systemic Exposure Study of CD5789 Cream in Adults and Adolescents With Lamellar Ichthyosis Not yet recruiting NCT03738800 Phase 2 CD5789 Cream 200 µg/g;CD5789 Cream 100 µg/g;CD5789 Cream Vehicle
5 5-fluorouracil Versus Placebo in Periocular Full Thickness Skin Grafts Terminated NCT02705352 Phase 2 5-Fluorouracil
6 Assessment of Changes of Periocular Skin Sensation Following Eyelid and Ocular Surface Surgeries Unknown status NCT02638610 Not Applicable
7 Diagnosis of Cervical Lesions in Women With Unhealthy Looking Cervix Unknown status NCT03150745 Not Applicable
8 Comparison Between Two Surgical Methods for Eyelid Ectropion: Tarsal Strip Alone Versus Tarsal Strip With Punctoplasty (Three Snips With or Without Diamond-shaped Resection) Completed NCT02893813
9 Lacrimal Drainage Resistance Study Completed NCT01766232
10 Comparison Between iLuxâ„¢ and LipiFlow® in the Treatment of Meibomian Gland Dysfunction Completed NCT03055832 Not Applicable
11 Spanish Registry of Mohs Surgery Recruiting NCT02310503

Search NIH Clinical Center for Ectropion

Cochrane evidence based reviews: ectropion

Sources

Genetic Tests for Ectropion

About this section
Sources

Anatomical Context for Ectropion

About this section

MalaCards organs/tissues related to Ectropion:

42
Skin, Lung, Eye, Cervix, Endothelial, Testes, Bone
Sources

Publications for Ectropion

About this section

Articles related to Ectropion:

(show top 50) (show all 497)
# Title Authors Year
1
Correction of cicatricial ectropion using non-ablative fractional laser resurfacing. ( 30056585 )
2019
2
Efficacy of lateral eyelid-block excision with canthoplasty and full-thickness skin grafting in lower eyelid cicatricial ectropion. ( 30390376 )
2019
3
Simultaneous Lateral Tarsal Strip and Medial Spindle Procedures for Cicatricial Ectropion. ( 30614837 )
2019
4
Frontosphenoidal Intraosseous Dermoid Cyst Presenting With Cicatricial Ectropion With Discharging Sinus. ( 30908467 )
2019
5
Essential skin shrinkage: cicatricial ectropion, a histopathologic evaluation and clinical analysis. ( 31106645 )
2019
6
Commentary on Simultaneous Lateral Tarsal Strip and Medial Spindle Procedures for Cicatricial Ectropion. ( 31107691 )
2019
7
Modification of the Lazy-T Procedure for Correction of Punctal Ectropion. ( 30444779 )
2019
8
A quantitative analysis of factors influencing lower lid retraction and involutional ectropion. ( 30467002 )
2019
9
Lower eyelid retractor (white-line) advancement to correct tarsal ectropion. ( 30851783 )
2019
10
Absorbable Barbed Suture Suspension of the Lower Eyelid to Prevent Ectropion After Mohs Micrographic Surgery. ( 30882512 )
2019
11
Congenital ectropion. ( 31092675 )
2019
12
Vector analysis of changes in corneal astigmatism following lateral tarsal strip procedure in patients with involutional ectropion or entropion. ( 30054850 )
2018
13
Ablative Fractional Laser Resurfacing With Laser-Assisted Delivery of 5-Fluorouracil for the Treatment of Cicatricial Ectropion and Periocular Scarring. ( 28658179 )
2018
14
Cicatricial Ectropion Secondary to Graft-Versus-Host Disease. ( 28746254 )
2018
15
Reversible cicatricial ectropion associated with EGFR inhibitors. ( 29336655 )
2018
16
Apremilast Use in a Case of Cicatricial Ectropion Secondary to Severe Lamellar Ichthyosis. ( 29346172 )
2018
17
Cicatricial ectropion surgery: a prospective study of long-term symptom control, patient satisfaction and anatomical success. ( 29920894 )
2018
18
Association of Blepharitis and Ectropion With Tumor Necrosis Factor α Inhibitor Treatment in Crohn Disease. ( 30419086 )
2018
19
Congenital ectropion uveae with glaucoma: a case report. ( 29027062 )
2018
20
Bilateral, presumed congenital ectropion uveae in a patient with pathologic myopia. ( 30128365 )
2018
21
Punctal Ectropion repair using the Raus-Garito clamp. ( 28853961 )
2018
22
"The influence of orbital vector on involutional entropion and ectropion". ( 28853964 )
2018
23
Entropion and ectropion repair: a snapshot of surgical practice in the United Kingdom. ( 29053043 )
2018
24
Recurrent Lower Eyelid Ectropion After Graft Surgery Using Autogenous Palmaris Longus Tendon. ( 29227410 )
2018
25
Severe ectropion in lamellar ichthyosis managed medically with oral acitretin. ( 29334142 )
2018
26
The vertical orbicularis oculi muscle turn-over procedure for the correction of paralytic ectropion of the lower eyelid. ( 29506332 )
2018
27
Angle closure glaucoma in congenital ectropion uvea. ( 29552671 )
2018
28
Correction of cicatricial and involutional lower eyelid ectropion with hyaluronic acid. ( 30094302 )
2018
29
Lateral tarsal strip versus lateral tarsal strip with three-snip punctoplasty for managing epiphora in involutional ectropion. ( 30217604 )
2018
30
Case report of Wolfe grafting for the management of bilateral cicatricial eyelid ectropion following severe burn injuries. ( 30237879 )
2018
31
The Use of a Double Suture and Conjunctival Cuts in the Lateral Tarsal Strip: A New Approach to Involutional Ectropion. ( 30320676 )
2018
32
Algorithm for the management of ectropion through medial and lateral canthopexy. ( 30466232 )
2018
33
Laterally Based Orbicularis Oculi Myocutaneous Flap: Revisiting for the Secondary Ectropion Correction. ( 30570593 )
2018
34
The Bipedicled Orbicularis Oculi Myocutaneous Flap for the Repair of Paralytic Ectropion. ( 30570666 )
2018
35
Capecitabine-Induced Bilateral Ectropion: A Rare Ocular Manifestation Requiring Surgical Intervention. ( 30886481 )
2018
36
Facial Pyoderma Gangrenosum Presenting With Cranial Nerve VII Palsy and Cicatricial Ectropion. ( 27893584 )
2017
37
Long term follow up of mucous membrane grafting for cicatricial ectropion in Ichthyosis: A case report. ( 28314226 )
2017
38
Chromomycosis, an unusual cause of cicatricial ectropion: a case report. ( 28380102 )
2017
39
Cicatricial ectropion in a patient treated with dupilumab. ( 29260094 )
2017
40
Congenital Ectropion Uveae with Glaucoma: A Case Report. ( 28764212 )
2017
41
Eyelid Necrosis and Secondary Cicatrical Ectropion Secondary to Levamisole-Associated Vasculitis. ( 26398243 )
2017
42
Surgical Microanatomy of Lower Eyelid Tarsal Ectropion Repair With a Putterman Ptosis Clamp. ( 27429229 )
2017
43
Ectropion in Facial Tissue Expansion in the Pediatric Population: Incidence, Risk Factors, and Treatment Options. ( 27529153 )
2017
44
Tarsal Strip Versus Tarsal Belt in Ectropion Correction: A Statistical Evaluation. ( 27755408 )
2017
45
Acquired ectropion uveae and secondary glaucoma due to trauma: report of 3 cases. ( 27768224 )
2017
46
Modified lateral tarsal strip for involutional entropion and ectropion surgery. ( 27817116 )
2017
47
Frangipane's Penitent's ectropion. ( 27986438 )
2017
48
Is it safe to use N-acetylcysteine in the treatment of bilateral ectropion on collodion baby? ( 28083950 )
2017
49
Congenital upper eyelids ectropion in Down's syndrome. ( 28194320 )
2017
50
Newly identified paired box 6 mutation of variant familial aniridia: Congenital iris ectropion with foveal hypoplasia. ( 28300742 )
2017
Sources

Variations for Ectropion

About this section
Sources

Expression for Ectropion

About this section
Search GEO for disease gene expression data for Ectropion.
Sources

Pathways for Ectropion

About this section

Pathways related to Ectropion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Ras signaling pathway 38
Show member pathways
 12.25 CDH1 CTNND1 NF1
2
Adherens junction 38
11.26 CDH1 CTNND1
3
FGF signaling pathway 1
11.04 CDH1 CTNND1
4
Arf6 trafficking events 1
10.97 CDH1 CTNND1
5
Cell adhesion_Cadherin-mediated cell adhesion 23
10.86 CDH1 CTNND1
6
Stabilization and expansion of the E-cadherin adherens junction 1
10.76 CDH1 CTNND1
7
E-cadherin signaling in the nascent adherens junction 1
10.47 CDH1 CTNND1
8
E-cadherin signaling in keratinocytes 1
9.9 CDH1 CTNND1
Sources

GO Terms for Ectropion

About this section

Cellular components related to Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 catenin complex GO:0016342 8.62 CDH1 CTNND1

Biological processes related to Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.5 NF1 PAX6 PHGDH
2 neural tube development GO:0021915 9.46 NF1 PHGDH
3 cell-cell junction assembly GO:0007043 9.43 CDH1 CTNND1
4 adherens junction organization GO:0034332 9.4 CDH1 CTNND1
5 spinal cord development GO:0021510 9.37 NF1 PHGDH
6 pituitary gland development GO:0021983 9.26 CDH1 PAX6
7 entry of bacterium into host cell GO:0035635 9.16 CDH1 CTNND1
8 keratinocyte differentiation GO:0030216 9.13 ABCA12 PAX6 TGM1
9 brain development GO:0007420 8.92 CTNND1 NF1 PAX6 PHGDH

Molecular functions related to Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion molecule binding GO:0050839 8.62 CDH1 CTNND1
Sources

Sources for Ectropion

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....