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MCID: ECZ002
MIFTS: 45

Eczema Herpeticum

Categories: Eye diseases, Infectious diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Eczema Herpeticum

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MalaCards integrated aliases for Eczema Herpeticum:

Name: Eczema Herpeticum 12 54 15 70 32
Herpes Simplex Eyelid Dermatitis 12 70
Kaposi Varicelliform Eruption 44 70
Herpes Simplex Dermatitis 12 70
Herpes Simplex Virus Eyelid Dermatitis 12
Herpes Simplex Dermatitis of Eyelid 12
Herpes Simplex Virus Dermatitis 12

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Skin diseases Eye diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:9123
ICD9CM 34 054.0 054.41
MeSH 44 D007617
NCIt 50 C35620
SNOMED-CT 67 186544000 52464003
ICD10 32 B00.0
UMLS 70 C0022504 C0153037 C0854331 more
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Summaries for Eczema Herpeticum

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Disease Ontology : 12 A herpes simplex that results in infection located in skin, effected by preexisting dermatosis, has material basis in Human herpesvirus 1 or Human herpesvirus 2. The infection has symptom watery blisters, has symptom fever, and has symptom swelling of the lymph nodes.

MalaCards based summary : Eczema Herpeticum, also known as herpes simplex eyelid dermatitis, is related to dermatitis and food allergy, and has symptoms including fever, watery blisters and swelling of the lymph nodes. An important gene associated with Eczema Herpeticum is FLG (Filaggrin), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Omalizumab and Interferon-gamma have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and bone marrow, and related phenotypes are hematopoietic system and immune system

Wikipedia : 73 Eczema herpeticum is a rare but severe disseminated infection that generally occurs at sites of skin... more...

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Related Diseases for Eczema Herpeticum

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Diseases related to Eczema Herpeticum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 201)
# Related Disease Score Top Affiliating Genes
1 dermatitis 31.1 TSLP IL4 IFNG FLG CCR6
2 food allergy 30.6 IL4 IFNG FLG
3 keratoconjunctivitis 30.5 TSLP IL4 IFNG
4 pemphigoid 30.4 IL4 IFNG
5 folliculitis 30.2 IL4 IFNG CCR6
6 lymphopenia 30.2 IL7R IL4 IFNG
7 dermatitis, atopic 30.2 TSLP IL4 IFNG FLG DEFB103A CRLF2
8 common cold 30.1 TSLP IL4 CCR6
9 contact dermatitis 30.0 IL4 IFNG FLG CCR6
10 skin disease 30.0 TSLP IRF2 IL4 IFNG FLG CCR6
11 rhinitis 29.9 TSLP IL4 IFNG
12 allergic disease 29.8 TSLP IL4 IFNG CCR6
13 chickenpox 29.7 IL4 IFNG DOCK8 CCR6
14 psoriasis 29.3 IRF2 IL4 IFNG FLG CCR6 CAMP
15 herpes simplex 10.9
16 exanthem 10.5
17 pemphigus 10.4
18 benign chronic pemphigus 10.4
19 interferon gamma, receptor 1, deficiency 10.3 IFNGR1 IFNG
20 trichinosis 10.3 TSLP IL4
21 guttate psoriasis 10.3 IFNG CAMP
22 immunodeficiency 27a 10.3 IFNGR1 IFNG
23 esophagitis 10.3 TSLP IL4 FLG
24 b-cell growth factor 10.3 IL4 IFNG
25 mite infestation 10.3 IL4 FLG
26 neurodermatitis 10.3 TSLP IL4 FLG
27 irritant dermatitis 10.3 TSLP IL4 FLG
28 atopic keratoconjunctivitis 10.3 IL4 IFNG
29 mental retardation, autosomal dominant 33 10.3 TSLP IL7R CRLF2
30 lymphoblastic leukemia, acute, with lymphomatous features 10.3 IL7R CRLF2
31 molluscum contagiosum 10.3
32 eales disease 10.2 IL4 IFNG
33 retinitis pigmentosa 46 10.2 IL4 IFNG
34 severe combined immunodeficiency, x-linked 10.2 TSLP IL7R IL4
35 nickel allergic contact dermatitis 10.2 IL4 IFNG
36 miliary tuberculosis 10.2 IFNGR1 IFNG
37 orofacial granulomatosis 10.2 IL4 IFNG FLG
38 tungiasis 10.2 IL4 IFNG
39 latex allergy 10.2 IL4 IFNG FLG
40 spotted fever rickettsiosis 10.2 IFNG IDO1
41 basidiobolomycosis 10.2 IL4 IDO1
42 gastroenteritis 10.2 TSLP IL4 IFNG
43 beta-lactam allergy 10.2 IL4 IFNGR1
44 ichthyosis vulgaris 10.2
45 pemphigus vulgaris, familial 10.2
46 bacterial infectious disease 10.2
47 acrodermatitis 10.2
48 impetigo 10.2
49 hypereosinophilic syndrome 10.2
50 lichen planus 10.2 IL4 IFNG FLG

Graphical network of the top 20 diseases related to Eczema Herpeticum:



Diseases related to Eczema Herpeticum
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Symptoms & Phenotypes for Eczema Herpeticum

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Symptoms:

12
  • • fever
  • • watery blisters
  • • swelling of the lymph nodes

MGI Mouse Phenotypes related to Eczema Herpeticum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.8 ADSS2 CAMP CCR6 CRLF2 DOCK8 IDO1
2 immune system MP:0005387 9.47 ADSS2 CAMP CCR6 CRLF2 DOCK8 IDO1
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Drugs & Therapeutics for Eczema Herpeticum

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Drugs for Eczema Herpeticum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omalizumab Approved, Investigational 242138-07-4
2 Interferon-gamma
3 interferons
4 methicillin
5 Respiratory System Agents
6 Anti-Asthmatic Agents
7 Immunoglobulins
8 Antibodies
9 Immunoglobulin E
10 Immunoglobulins, Intravenous
11 Anti-Allergic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Integrated Extreme Trait Analysis to Understand the Etiology of Eczema Herpeticum (ADRN-06) Completed NCT03038932
2 Investigation of Reduced Interferon Responses in Peripheral Blood Mononuclear Cells of Participants With Atopic Dermatitis and a History of Eczema Herpeticum (ADRN-01) Completed NCT01429311
3 Genetics of Atopic Dermatitis - Eczema Herpeticum Completed NCT00515047
4 Pilot Study To Determine The Underlying Mechanisms For Infection And Colonization By Staphylococcus Aureus Of The Skin Of Atopic Dermatitis Subjects With And Without A History Of Eczema Herpeticum (ADVN MRSA 10) Completed NCT00822276
5 Risk Factors in Atopic Dermatitis for the Development of Eczema Herpeticum Completed NCT00438022
6 Registry for the Atopic Dermatitis Research Network (ADRN-02) Completed NCT01494142
7 Investigate the Impact of Increased IgE on Innate Anti-herpes Simplex Virus 1 Responses in the Eczema Herpeticum Patients Recruiting NCT04060550
8 Role of Staphylococci on Cytokine and T Cell Profiles in the Pathogenesis of Atopic Dermatitis and Eczema Herpeticum Recruiting NCT04274348

Search NIH Clinical Center for Eczema Herpeticum

Cochrane evidence based reviews: kaposi varicelliform eruption

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Genetic Tests for Eczema Herpeticum

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Anatomical Context for Eczema Herpeticum

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The Foundational Model of Anatomy Ontology organs/tissues related to Eczema Herpeticum:

19
Skin

MalaCards organs/tissues related to Eczema Herpeticum:

40
Eye, Skin, Bone Marrow, Bone, Lung, T Cells, Lymph Node
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Publications for Eczema Herpeticum

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Articles related to Eczema Herpeticum:

(show top 50) (show all 307)
# Title Authors PMID Year
1
Molecular pathogenesis and clinical implications of eczema herpeticum. 61 54
18620613 2008
2
Herpes simplex virus 1 proteins can induce skin inflammation in an atopic dermatitis-like mouse model. 61
33751678 2021
3
Eczema Herpeticum in children with burns. 61
33679925 2021
4
Pooled safety analysis of baricitinib in adult patients with atopic dermatitis from 8 randomized clinical trials. 61
32926462 2021
5
Whole genome sequencing identifies novel genetic mutations in patients with eczema herpeticum. 61
33548076 2021
6
The infectious complications of atopic dermatitis. 61
32771354 2021
7
Kaposi Varicelliform Eruption on Sunburned Skin. 61
32986970 2021
8
Darier disease complicated by severe Kaposi varicelliform eruption resistant to acyclovir. 61
33145898 2020
9
Visual Dermatology: Eczema Herpeticum. 61
32442019 2020
10
Eczema Herpeticum: Clinical and Pathophysiological Aspects. 61
31836943 2020
11
Eczema herpeticum in a patient With Hailey-Hailey disease confounded by coexistent psoriasis. 61
32717004 2020
12
Recurrent eczema herpeticum - a retrospective European multicenter study evaluating the clinical characteristics of eczema herpeticum cases in atopic dermatitis patients. 61
31733162 2020
13
Frequency and Clinical Features Associated With Eczema Herpeticum in Hospitalized Children With Presumed Atopic Dermatitis Skin Infection. 61
31764378 2020
14
Kaposi Varicelliform Eruption Associated With Chickenpox in a Liver Transplant Recipient. 61
29957162 2020
15
Association of Atopic Dermatitis With Bacterial, Fungal, Viral, and Sexually Transmitted Skin Infections. 61
32049716 2020
16
Bullous Pemphigoid in a Patient with Longstanding Hailey-Hailey Disease Complicated by Eczema Herpeticum: Managing the Coexistence of Three Different Blistering Conditions. 61
32308791 2020
17
Pediatric dermatology emergencies. 61
32352437 2020
18
Osteomyelitis complicating secondarily infected atopic eczema: two case reports and a narrative literature review. 61
32008574 2020
19
Kaposi Varicelliform Eruption in a Patient with Pemphigus Vulgaris: A Case Report and Review of the Literature. 61
33489386 2020
20
IgE reactivity against herpes simplex virus 1 in patients with atopic dermatitis complicated by eczema herpeticum. 61
31315153 2020
21
Eczema herpeticum emerging during atopic dermatitis in infancy. 61
32558432 2020
22
Eczema herpeticum: A medical emergency in patients with atopic dermatitis. 61
32226756 2020
23
Disseminated bullous impetigo and atopic dermatitis: Case series and literature review. 61
31755570 2020
24
Atopic dermatitis. 61
31690388 2019
25
Seborrhea herpeticum: cutaneous herpes simplex virus infection within infantile seborrheic dermatitis. 61
31886781 2019
26
Punched-out erosions with scalloped borders: Group A Streptococcal pustulosis. 61
31410890 2019
27
Recurrent herpes labialis in the pediatric population: Prevalence, therapeutic studies, and associated complications. 61
31497896 2019
28
Bilateral corneal geographic ulcers in a patient with eczema herpeticum. 61
31063273 2019
29
Hailey-Hailey Disease with Superimposed Eczema Herpeticum Caused by Herpes Simplex Virus Type 2 Infection in a Burn Unit: A Case Report and Literature Review. 61
31777694 2019
30
Concurrence of Acrodermatitis Enteropathica and Eczema Herpeticum in a Child with Atopic Dermatitis. 61
31607883 2019
31
Replicated methylation changes associated with eczema herpeticum and allergic response. 61
31443688 2019
32
Infections in Dupilumab Clinical Trials in Atopic Dermatitis: A Comprehensive Pooled Analysis. 61
31066001 2019
33
Disseminated zoster in an adult patient with extensive burns: a case report. 61
31122255 2019
34
Darier disease with disseminated herpes simplex virus type 2 infection. 61
31046908 2019
35
Antibiotic choice and methicillin-resistant Staphylococcus aureus rate in children hospitalized for atopic dermatitis. 61
30529713 2019
36
Kaposi varicelliform eruption induced by methotrexate in an adult atopic dermatitis patient. 61
30659717 2019
37
[Infantile atypical hand-foot-mouth disease with features of eczema herpeticum and acrodermatitis]. 61
30652458 2019
38
An 8-Month-Old Girl With Vesicular Rash. 61
30956997 2019
39
Eczema herpeticum in Darier's disease: a topical storm. 61
31528287 2019
40
Loss of ATP2A2 Allows Herpes Simplex Virus 1 Infection of a Human Epidermis Model by Disrupting Innate Immunity and Barrier Function. 61
29870688 2018
41
Atypical Varicella-Zoster Kaposi Varicelliform Eruption in Sézary Syndrome. 61
30211729 2018
42
Common features of atopic dermatitis with hypoproteinemia. 61
30304908 2018
43
Skin diseases associated with atopic dermatitis. 61
30217275 2018
44
Ivacaftor treatment of cystic fibrosis in children aged 12 to <24 months and with a CFTR gating mutation (ARRIVAL): a phase 3 single-arm study. 61
29886024 2018
45
Dermatology emergencies: handy hints for the acute medical team. 61
29995550 2018
46
A case of Kaposi varicelliform eruption progressing to herpes simplex virus hepatitis in an immunocompetent patient. 61
29446473 2018
47
Ankyrin repeat domain 1 regulates innate immune responses against herpes simplex virus 1: A potential role in eczema herpeticum. 61
29371118 2018
48
Quantitation of peptides from non-invasive skin tapings using isotope dilution and tandem mass spectrometry. 61
29601982 2018
49
Disseminated herpes simplex virus: a case of eczema herpeticum causing viral encephalitis. 61
29741524 2018
50
Patients with atopic dermatitis and history of eczema herpeticum elicit herpes simplex virus-specific type 2 immune responses. 61
29155096 2018
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Variations for Eczema Herpeticum

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Expression for Eczema Herpeticum

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Search GEO for disease gene expression data for Eczema Herpeticum.
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Pathways for Eczema Herpeticum

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Pathways related to Eczema Herpeticum according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.83 IRF7 IRF3 IRF2 IL7R IL4 IFNGR1
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.16 IRF7 IRF3 IRF2 IL7R IL4 IFNGR1
3
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 65
Show member pathways
 12.35 IRF7 IRF3 IRF2 IFNG
4
Interferon gamma signaling 65
Show member pathways
 12.21 IRF7 IRF3 IRF2 IFNGR1 IFNG
5
NF-kappaB Signaling 4
12.15 IRF7 IRF3 IRF2 IL4 IFNG IDO1
6
NOD-like receptor signaling pathway 36
12.05 IRF7 IRF3 DEFB103A CAMP
7
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.01 IRF7 IRF3 IRF2 IL4 IFNG
8
Factors involved in megakaryocyte development and platelet production 65
11.93 IRF7 IRF3 IRF2 DOCK8
9
JAK-STAT signaling pathway 36
Show member pathways
 11.83 TSLP IL7R IL4 IFNGR1 IFNG CRLF2
10
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.8 IL7R IL4 IFNG
11
Dendritic Cells Developmental Lineage Pathway 64
11.57 IRF2 IL7R IFNG
12
Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway 1
11.33 TSLP IL7R CRLF2
13
Th2 Differentiation Pathway 64
11.3 IL4 IFNG CRLF2
14
Type II interferon signaling (IFNG) 1
11.11 IRF2 IFNGR1 IFNG
15
Innate Lymphoid Cell Differentiation Pathways 64
11 TSLP IL7R IL4 IFNG CRLF2 CCR6
16
Development and heterogeneity of the ILC family 1
10.94 TSLP IL4 IFNG
17
Hypertrophy Model 1
10.87 IFNG ANKRD1
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GO Terms for Eczema Herpeticum

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Biological processes related to Eczema Herpeticum according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 10 IRF7 IRF3 IRF2 IL4 IFNG ANKRD1
2 response to virus GO:0009615 9.8 IRF7 IFNGR1 IFNG
3 defense response to virus GO:0051607 9.8 IRF7 IRF3 IRF2 IFNG
4 defense response to Gram-positive bacterium GO:0050830 9.79 IL7R DEFB103A CAMP
5 defense response to Gram-negative bacterium GO:0050829 9.74 TSLP DEFB103A CAMP
6 positive regulation of cell proliferation GO:0008284 9.73 TSLP IL7R IL4 IFNG CRLF2 CAMP
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 TSLP IL4 IFNG
8 type I interferon signaling pathway GO:0060337 9.69 IRF7 IRF3 IRF2
9 positive regulation of amyloid-beta formation GO:1902004 9.63 IFNGR1 IFNG
10 astrocyte activation GO:0048143 9.62 IFNGR1 IFNG
11 regulation of type I interferon production GO:0032479 9.62 IRF7 IRF3
12 positive regulation of type I interferon-mediated signaling pathway GO:0060340 9.61 IRF7 IRF3
13 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.6 IFNGR1 IFNG
14 negative regulation of amyloid-beta clearance GO:1900222 9.59 IFNGR1 IFNG
15 positive regulation of MHC class II biosynthetic process GO:0045348 9.58 IL4 IFNG
16 positive regulation of interleukin-13 production GO:0032736 9.58 TSLP IL4
17 positive regulation of interleukin-5 production GO:0032754 9.56 TSLP CRLF2
18 killing by host of symbiont cells GO:0051873 9.55 DEFB103A CAMP
19 interleukin-7-mediated signaling pathway GO:0038111 9.54 TSLP IL7R CRLF2
20 microglial cell activation GO:0001774 9.5 IL4 IFNGR1 IFNG
21 positive regulation of cellular respiration GO:1901857 9.48 IL4 IFNG
22 neuroinflammatory response GO:0150076 9.46 IL4 IFNG
23 positive regulation of mast cell activation GO:0033005 9.43 TSLP CRLF2
24 MDA-5 signaling pathway GO:0039530 9.4 IRF7 IRF3
25 negative regulation of T cell apoptotic process GO:0070233 9.33 IL7R IDO1 DOCK8
26 positive regulation of STAT cascade GO:1904894 9.13 TSLP IL7R CRLF2
27 interferon-gamma-mediated signaling pathway GO:0060333 9.02 IRF7 IRF3 IRF2 IFNGR1 IFNG

Molecular functions related to Eczema Herpeticum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor activity GO:0004896 8.8 IL7R IFNGR1 CRLF2
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Sources for Eczema Herpeticum

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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