MCID: ECZ002
MIFTS: 49

Eczema Herpeticum

Categories: Eye diseases, Infectious diseases, Skin diseases

Aliases & Classifications for Eczema Herpeticum

MalaCards integrated aliases for Eczema Herpeticum:

Name: Eczema Herpeticum 12 56 15 74
Herpes Simplex Eyelid Dermatitis 12 74
Kaposi Varicelliform Eruption 45 74
Herpes Simplex Dermatitis 12 74
Herpes Simplex Virus Eyelid Dermatitis 12
Herpes Simplex Dermatitis of Eyelid 12
Herpes Simplex Virus Dermatitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9123
ICD9CM 36 054.0 054.41
MeSH 45 D007617
NCIt 51 C35620
SNOMED-CT 69 38875006 52464003
ICD10 34 B00.0

Summaries for Eczema Herpeticum

Disease Ontology : 12 A herpes simplex that results in infection located in skin, effected by preexisting dermatosis, has material basis in Human herpesvirus 1 or Human herpesvirus 2. The infection has symptom watery blisters, has symptom fever, and has symptom swelling of the lymph nodes.

MalaCards based summary : Eczema Herpeticum, also known as herpes simplex eyelid dermatitis, is related to dermatitis and dermatitis, atopic, and has symptoms including fever, watery blisters and swelling of the lymph nodes. An important gene associated with Eczema Herpeticum is FLG (Filaggrin), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Formaldehyde and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, skin and lymph node, and related phenotypes are hematopoietic system and immune system

Wikipedia : 77 Eczema herpeticum is a rare but severe disseminated infection that generally occurs at sites of skin... more...

Related Diseases for Eczema Herpeticum

Diseases related to Eczema Herpeticum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 dermatitis 31.2 FLG IFNG TSLP
2 dermatitis, atopic 30.3 CAMP FLG IFNG TSLP
3 herpes simplex 10.6
4 chickenpox 10.3
5 pemphigus 10.3
6 benign chronic pemphigus 10.2
7 pemphigus vulgaris, familial 10.2
8 pemphigus vulgaris 10.2
9 darier-white disease 10.2
10 epidermolysis bullosa simplex, generalized 10.2
11 hepatitis 10.2
12 pemphigus foliaceus 10.2
13 epidermolysis bullosa 10.2
14 epidermolysis bullosa simplex 10.2
15 sezary's disease 10.2
16 blepharitis 10.2
17 nasal cavity disease 10.2 FLG TSLP
18 pfeiffer syndrome 10.1
19 hypophosphatemic bone disease 10.1
20 ichthyosis vulgaris 10.1
21 mycosis fungoides 10.1
22 burns 10.1
23 cataract 10.1
24 skin conditions 10.1
25 variola major 10.1
26 tinea cruris 10.1
27 ichthyosis 10.1
28 femoral neuropathy 10.1
29 folliculitis 10.1
30 viral encephalitis 10.1
31 neuropathy 10.1
32 genital herpes 10.1
33 smallpox 10.1
34 dermatophytosis 10.1
35 meningitis 10.1
36 encephalitis 10.1
37 fasciitis 10.1
38 neonatal herpes 10.1
39 depression 10.1
40 pneumococcal meningitis 10.1
41 bronchial disease 10.0 IFNGR1 TSLP
42 peanut allergy 10.0 FLG IFNG
43 pediatric lymphoma 10.0 IRF3 IRF7
44 orofacial granulomatosis 10.0 FLG IFNG
45 lichen disease 10.0 FLG IFNG
46 interferon gamma, receptor 1, deficiency 10.0 IFNG IFNGR1
47 penicillin allergy 10.0 IFNG IFNGR1
48 extrapulmonary tuberculosis 9.9 IFNG IFNGR1
49 lepromatous leprosy 9.9 IFNG IFNGR1
50 allergic contact dermatitis 9.9 FLG IFNG

Graphical network of the top 20 diseases related to Eczema Herpeticum:



Diseases related to Eczema Herpeticum

Symptoms & Phenotypes for Eczema Herpeticum

Symptoms:

12
  • fever
  • watery blisters
  • swelling of the lymph nodes

MGI Mouse Phenotypes related to Eczema Herpeticum:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CAMP IFNG IFNGR1 IRF2 IRF7 TSLP
2 immune system MP:0005387 9.17 CAMP IFNG IFNGR1 IRF2 IRF3 IRF7

Drugs & Therapeutics for Eczema Herpeticum

Drugs for Eczema Herpeticum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Formaldehyde Approved, Vet_approved Early Phase 1 50-00-0 712
2 Anti-Infective Agents
3 Antiviral Agents
4 Interferon-gamma
5 interferons
6 Anti-Bacterial Agents
7 methicillin
8 Immunologic Factors Early Phase 1,Not Applicable
9 Vaccines Early Phase 1,Not Applicable

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Identifying Risk Factors for Eczema Herpeticum in Individuals With Atopic Dermatitis Completed NCT00438022
2 Interferon Responses in Eczema Herpeticum Completed NCT01429311
3 Identifying Genetic Determinants of Eczema Herpeticum and Other Viral Infections in Individuals With Atopic Dermatitis Completed NCT00515047
4 The Underlying Mechanisms For S. Aureus Infection And Colonization Of Skin in People With Atopic Dermatitis With And Without Eczema Herpeticum (MRSA) Completed NCT00822276
5 Registry for the Atopic Dermatitis Research Network Completed NCT01494142
6 Atopic Dermatitis Research Network (ADRN) Influenza Vaccine Pilot Completed NCT01518478 Early Phase 1 Fluzone® Intradermal (Sanofi Pasteur Inc.)
7 Atopic Dermatitis Research Network (ADRN) Influenza Vaccine Study Completed NCT01737710 Not Applicable
8 Immune Response to Varicella Vaccination in Children With Atopic Dermatitis Completed NCT00406081
9 ADRN Barrier/Immunoprofiling Exploratory Pilot Study Completed NCT02115399
10 Comparison of Cathelicidin Expression in Skin and Saliva in Patients With Atopic Dermatitis and Psoriasis Completed NCT00407979
11 Role of Antimicrobial Peptides in Host Defense Against Vaccinia Virus Completed NCT00407069
12 Etiology of Eczema Herpeticum (EH) Recruiting NCT03038932

Search NIH Clinical Center for Eczema Herpeticum

Cochrane evidence based reviews: kaposi varicelliform eruption

Genetic Tests for Eczema Herpeticum

Anatomical Context for Eczema Herpeticum

The Foundational Model of Anatomy Ontology organs/tissues related to Eczema Herpeticum:

20
Skin

MalaCards organs/tissues related to Eczema Herpeticum:

42
Skin, Lymph Node, Bone, Colon, T Cells, Bone Marrow, Eye

Publications for Eczema Herpeticum

Articles related to Eczema Herpeticum:

(show top 50) (show all 146)
# Title Authors Year
1
Bilateral corneal geographic ulcers in a patient with eczema herpeticum. ( 31063273 )
2019
2
Patients with atopic dermatitis and history of eczema herpeticum elicit herpes simplex virus-specific type 2 immune responses. ( 29155096 )
2018
3
Epidemiology of Eczema Herpeticum in Hospitalized U.S. Children: Analysis of a Nationwide Cohort. ( 28927889 )
2018
4
Ankyrin repeat domain 1 regulates innate immune responses against herpes simplex virus 1: A potential role in eczema herpeticum. ( 29371118 )
2018
5
Disseminated herpes simplex virus: a case of eczema herpeticum causing viral encephalitis. ( 29741524 )
2018
6
Defective natural killer cell activity in a mouse model of eczema herpeticum. ( 27476888 )
2017
7
Eczema herpeticum in early pregnancy. ( 28385896 )
2017
8
Eczema Herpeticum. ( 28813215 )
2017
9
Eczema Herpeticum. ( 28992872 )
2017
10
Characterization of children with recurrent eczema herpeticum and response to treatment with interferon-gamma. ( 29144049 )
2017
11
Validation of database search strategies for the epidemiological study of eczema herpeticum. ( 26822010 )
2016
12
A child presenting with primary gingivostomatitis and eczema herpeticum. ( 26864720 )
2016
13
A Fatal Case of Eczema Herpeticum With Septic Shock Due to Methicillin-Resistant Staphylococcus aureus. ( 27369040 )
2016
14
Oral treatment with valacyclovir for HSV-2-associated eczema herpeticum in a 9-month-old infant: A case report. ( 27442669 )
2016
15
Vitamin D and antimicrobial peptide levels in patients with atopic dermatitis and atopic dermatitis complicated by eczema herpeticum: A pilot study. ( 27523434 )
2016
16
Relationship Between the Presence of Eczema Herpeticum and the Significance of Clinical and Laboratory Tests in Korean Children With Atopic Dermatitis. ( 27713812 )
2016
17
Management of eczema herpeticum in a Burn Unit. ( 27812048 )
2016
18
Eczema herpeticum in a wrestler. ( 24714395 )
2015
19
Fifteen-minute consultation: eczema herpeticum in a child. ( 25406412 )
2015
20
A corneal dendritic lesion with a skin eruption: eczema herpeticum, an important differential diagnosis. ( 25636633 )
2015
21
Exaggerated IDO1 expression and activity in Langerhans cells from patients with atopic dermatitis upon viral stimulation: a potential predictive biomarker for high risk of Eczema herpeticum. ( 26198597 )
2015
22
Eczema Herpeticum: Would You Know It If You Saw It? ( 26241712 )
2015
23
Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum. ( 26343451 )
2015
24
Pathological role of regulatory T cells in the initiation and maintenance of eczema herpeticum lesions. ( 24379126 )
2014
25
Identification of novel gene signatures in patients with atopic dermatitis complicated by eczema herpeticum. ( 25159465 )
2014
26
Empiric antibiotics and outcomes of children hospitalized with eczema herpeticum. ( 22994962 )
2013
27
Topical corticosteroids and hospital length of stay in children with eczema herpeticum. ( 23039248 )
2013
28
Eczema herpeticum with herpetic folliculitis after bone marrow transplant under prophylactic acyclovir: are patients with underlying dermatologic disorders at higher risk? ( 23387866 )
2013
29
Why is eczema herpeticum unexpectedly rare? ( 23439082 )
2013
30
Atopic dermatitis complicated by eczema herpeticum is associated with HLA B7 and reduced interferon-γ-producing CD8+ T cells. ( 23600999 )
2013
31
Eczema herpeticum. ( 21852062 )
2012
32
Genetic variants in interferon regulatory factor 2 (IRF2) are associated with atopic dermatitis and eczema herpeticum. ( 22113474 )
2012
33
Eczema herpeticum. ( 22433376 )
2012
34
Eczema herpeticum in children: clinical features and factors predictive of hospitalization. ( 22575249 )
2012
35
What is your diagnosis? The diagnosis: Kaposi varicelliform eruption (Eczema herpeticum). ( 22908727 )
2012
36
Eczema herpeticum complicating topical 5-Fluorouracil therapy. ( 23010835 )
2012
37
Eczema herpeticum: a medical emergency. ( 23242894 )
2012
38
Eczema herpeticum: making the diagnosis in the emergency department. ( 18584994 )
2011
39
Comparative proteomic profiling of patients with atopic dermatitis based on history of eczema herpeticum infection and Staphylococcus aureus colonization. ( 21211653 )
2011
40
Atopic dermo-respiratory syndrome is a correlate of eczema herpeticum. ( 21255038 )
2011
41
The clinical spectrum and therapeutic challenge of eczema herpeticum. ( 21261703 )
2011
42
Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-γ response. ( 21458658 )
2011
43
Urgent referrals. Eczema herpeticum, pemphigus vulgaris, perinephric abscess, quinsy, necrotising fasciitis. ( 21510509 )
2011
44
Delayed acyclovir and outcomes of children hospitalized with eczema herpeticum. ( 22084327 )
2011
45
Mannan-binding lectin levels and activity are not altered in atopic dermatitis patients with a history of eczema herpeticum. ( 22110485 )
2011
46
Eczema herpeticum in pregnancy. ( 25386284 )
2011
47
Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum. ( 20466416 )
2010
48
History of eczema herpeticum is associated with the inability to induce human β-defensin (HBD)-2, HBD-3 and cathelicidin in the skin of patients with atopic dermatitis. ( 20545685 )
2010
49
Eczema herpeticum in a patient with terminal renal failure under narrow-band uvb therapy. ( 20606898 )
2010
50
Kaposi's varicelliform eruption (eczema herpeticum) in an infant. ( 20706828 )
2010

Variations for Eczema Herpeticum

Expression for Eczema Herpeticum

Search GEO for disease gene expression data for Eczema Herpeticum.

Pathways for Eczema Herpeticum

Pathways related to Eczema Herpeticum according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.63 CAMP IFNG IFNGR1 IRF2 IRF3 IRF7
2
Show member pathways
12.94 IFNG IFNGR1 IRF2 IRF3 IRF7
3
Show member pathways
12.49 CAMP IFNG IFNGR1 IRF3 IRF7
4
Show member pathways
12.33 IFNG IRF2 IRF3 IRF7
5
Show member pathways
12.07 IFNG IFNGR1 TSLP
6 12.07 IFNG IRF2 IRF3 IRF7
7
Show member pathways
11.98 IFNG IFNGR1 IRF3
8 11.89 CAMP IFNG IFNGR1
9
Show member pathways
11.83 IFNG IRF2 IRF3 IRF7
10 11.78 IRF2 IRF3 IRF7
11
Show member pathways
11.51 IFNG IFNGR1 IRF2 IRF3 IRF7
12 11.47 IFNG TSLP
13 11.42 IFNG IRF2
14
Show member pathways
11.24 IFNG IFNGR1
15 11 IFNG TSLP
16
Show member pathways
10.84 IRF3 IRF7
17 10.7 IFNG IFNGR1 IRF2

GO Terms for Eczema Herpeticum

Biological processes related to Eczema Herpeticum according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.71 IFNG IRF2 IRF7
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.55 IFNG TSLP
3 response to virus GO:0009615 9.54 IFNG IFNGR1 IRF7
4 positive regulation of type I interferon production GO:0032481 9.52 IRF3 IRF7
5 positive regulation of interferon-beta production GO:0032728 9.51 IRF3 IRF7
6 type I interferon signaling pathway GO:0060337 9.5 IRF2 IRF3 IRF7
7 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.49 IRF3 IRF7
8 positive regulation of interferon-alpha production GO:0032727 9.48 IRF3 IRF7
9 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.46 IFNG IFNGR1
10 regulation of type I interferon production GO:0032479 9.43 IRF3 IRF7
11 MDA-5 signaling pathway GO:0039530 9.26 IRF3 IRF7
12 defense response to virus GO:0051607 9.26 IFNG IRF2 IRF3 IRF7
13 positive regulation of type I interferon-mediated signaling pathway GO:0060340 9.1 IRF7
14 interferon-gamma-mediated signaling pathway GO:0060333 9.02 IFNG IFNGR1 IRF2 IRF3 IRF7
15 type I interferon biosynthetic process GO:0045351 8.85 IRF7

Molecular functions related to Eczema Herpeticum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 8.8 IRF2 IRF3 IRF7

Sources for Eczema Herpeticum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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