MCID: ECZ002
MIFTS: 44

Eczema Herpeticum

Categories: Eye diseases, Infectious diseases, Skin diseases
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Aliases & Classifications for Eczema Herpeticum

MalaCards integrated aliases for Eczema Herpeticum:

Name: Eczema Herpeticum 11 53 14 71 75 31
Herpes Simplex Eyelid Dermatitis 11 71
Kaposi Varicelliform Eruption 43 71
Herpes Simplex Dermatitis 11 71
Herpes Simplex Virus Eyelid Dermatitis 11
Herpes Simplex Dermatitis of Eyelid 11
Herpes Simplex Virus Dermatitis 11

Classifications:



External Ids:

Disease Ontology 11 DOID:9123
ICD9CM 34 054.0 054.41
MeSH 43 D007617
NCIt 49 C35620
SNOMED-CT 68 186544000 52464003
ICD10 31 B00.0
UMLS 71 C0022504 C0153037 C0854331 more

Summaries for Eczema Herpeticum

Disease Ontology: 11 A herpes simplex that results in infection located in skin, effected by preexisting dermatosis, has material basis in Human herpesvirus 1 or Human herpesvirus 2. The infection has symptom watery blisters, has symptom fever, and has symptom swelling of the lymph nodes.

MalaCards based summary: Eczema Herpeticum, also known as herpes simplex eyelid dermatitis, is related to molluscum contagiosum and chickenpox, and has symptoms including fever, watery blisters and swelling of the lymph nodes. An important gene associated with Eczema Herpeticum is ADSS2 (Adenylosuccinate Synthase 2), and among its related pathways/superpathways are Innate Immune System and Keratinization. The drugs Meticillin and Omalizumab have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and bone marrow, and related phenotypes are immune system and hematopoietic system

Wikipedia: 75 Eczema herpeticum is a rare but severe disseminated infection that generally occurs at sites of skin... more...

Related Diseases for Eczema Herpeticum

Diseases related to Eczema Herpeticum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 258)
# Related Disease Score Top Affiliating Genes
1 molluscum contagiosum 30.6 LORICRIN IVL FLG
2 chickenpox 30.6 IL4 DOCK8 CCR6
3 blepharitis 30.5 IL4 IL13 CCR6
4 keratosis 30.5 LORICRIN IVL FLG
5 sezary's disease 30.5 IL4 IL31 CCR6
6 dermatitis 30.4 TSLP SPINK5 LORICRIN IVL IL4 IL31
7 epidermolysis bullosa 30.4 LORICRIN IVL FLG
8 epidermolysis bullosa simplex 30.4 LORICRIN IVL FLG
9 pemphigoid 30.3 IL4 IL31 IL13
10 chronic rhinitis 30.2 IL4 IL13
11 conjunctivitis 30.2 IL4 IL13 IGHE
12 common cold 30.2 TSLP IL4 IL13 CCR6
13 psoriasis 1 30.1 CDSN CCR6
14 celiac disease 1 30.1 TSLP IL4 IL13 CCR6
15 bullous pemphigoid 30.1 IVL IL4 IGHE
16 hypereosinophilic syndrome 30.1 IL4 IL13 IGHE
17 folliculitis 30.1 IL4 DEFB4A CCR6
18 ichthyosis 30.0 SPINK5 LORICRIN IVL FLG
19 scabies 30.0 IL4 IL31 IL13 FLG CCR6
20 food allergy 30.0 TSLP IL4 IL13 IGHE FLG CCR6
21 seborrheic dermatitis 29.9 SPINK5 LORICRIN FLG DEFB4A CCR6
22 dermatophytosis 29.9 DEFB4A CCR6 CAMP
23 rhinitis 29.8 TSLP IL4 IL13 IGHE FLG
24 allergic disease 29.6 TSLP IL4 IL13 IGHE FLG CCR6
25 fungal infectious disease 29.4 IL4 IL13 DOCK8 DEFB4A CCR6
26 ichthyosis vulgaris 29.2 TSLP SPINK5 LORICRIN IVL FLG2 FLG
27 autosomal recessive congenital ichthyosis 29.0 SPINK5 LORICRIN IVL FLG DEFB4A CDSN
28 contact dermatitis 28.6 TSLP SPINK5 LORICRIN IVL IL4 IL31
29 dermatitis, atopic 28.1 TSLP SPINK5 LORICRIN IVL IL4 IL31
30 skin disease 27.9 TSLP SPINK5 LORICRIN IVL IL4 IL31
31 psoriasis 27.7 SPINK5 LORICRIN IVL IL4 IL31 IL13
32 herpes simplex 10.8
33 exanthem 10.6
34 darier-white disease 10.5
35 pemphigus 10.5
36 viral infectious disease 10.5
37 benign chronic pemphigus 10.4
38 dermatitis, atopic, 2 10.4
39 photoallergic dermatitis 10.3 FLG CCR6
40 occupational dermatitis 10.3 IL31 FLG
41 shrimp allergy 10.3 IL13 CCR6
42 adult-onset severe asthma 10.3 TSLP CCR6
43 eosinophilic gastritis 10.3 TSLP IL13
44 chromium allergic contact dermatitis 10.3 IL4 IL13
45 cardiomyopathy, familial hypertrophic, 12 10.3 DEFB103B DEFB103A
46 esophageal candidiasis 10.3 IL13 CCR6
47 thunderstorm triggered asthma 10.3 IL4 IL13
48 pemphigus vulgaris, familial 10.3
49 toxic shock syndrome 10.3
50 encephalitis 10.3

Graphical network of the top 20 diseases related to Eczema Herpeticum:



Diseases related to Eczema Herpeticum

Symptoms & Phenotypes for Eczema Herpeticum

Symptoms:

11
  • fever
  • watery blisters
  • swelling of the lymph nodes

MGI Mouse Phenotypes related to Eczema Herpeticum:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.83 ADSS2 CAMP CCR6 CDSN DEFB103A DEFB103B
2 hematopoietic system MP:0005397 9.5 ADSS2 CAMP CCR6 CDSN DEFB103A DEFB103B

Drugs & Therapeutics for Eczema Herpeticum

Drugs for Eczema Herpeticum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Meticillin Approved, Investigational 61-32-5 6087
2
Omalizumab Approved, Investigational 242138-07-4
3 interferons
4 Interferon-gamma
5 Immunoglobulins, Intravenous
6 Anti-Asthmatic Agents
7 Immunoglobulins
8 Immunoglobulin E
9 Anti-Allergic Agents
10 Respiratory System Agents
11 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Integrated Extreme Trait Analysis to Understand the Etiology of Eczema Herpeticum (ADRN-06) Completed NCT03038932
2 Risk Factors in Atopic Dermatitis for the Development of Eczema Herpeticum Completed NCT00438022
3 Pilot Study To Determine The Underlying Mechanisms For Infection And Colonization By Staphylococcus Aureus Of The Skin Of Atopic Dermatitis Subjects With And Without A History Of Eczema Herpeticum (ADVN MRSA 10) Completed NCT00822276
4 Genetics of Atopic Dermatitis - Eczema Herpeticum Completed NCT00515047
5 Investigation of Reduced Interferon Responses in Peripheral Blood Mononuclear Cells of Participants With Atopic Dermatitis and a History of Eczema Herpeticum (ADRN-01) Completed NCT01429311
6 Registry for the Atopic Dermatitis Research Network (ADRN-02) Completed NCT01494142
7 Investigate the Impact of Increased IgE on Innate Anti-herpes Simplex Virus 1 Responses in the Eczema Herpeticum Patients Recruiting NCT04060550
8 Role of Staphylococci on Cytokine and T Cell Profiles in the Pathogenesis of Atopic Dermatitis and Eczema Herpeticum Recruiting NCT04274348

Search NIH Clinical Center for Eczema Herpeticum

Cochrane evidence based reviews: kaposi varicelliform eruption

Genetic Tests for Eczema Herpeticum

Anatomical Context for Eczema Herpeticum

Organs/tissues related to Eczema Herpeticum:

FMA: Skin
MalaCards : Skin, T Cells, Bone Marrow, Breast, Lung, Bone

Publications for Eczema Herpeticum

Articles related to Eczema Herpeticum:

(show top 50) (show all 315)
# Title Authors PMID Year
1
Molecular pathogenesis and clinical implications of eczema herpeticum. 53 62
18620613 2008
2
Safety of tralokinumab in adult patients with moderate-to-severe atopic dermatitis: pooled analysis of five randomized, double-blind, placebo-controlled phase II and phase III trials. 62
36082590 2022
3
The Genetics of Eczema Herpeticum. 62
36114947 2022
4
Biomarkers associated with the development of comorbidities in patients with atopic dermatitis: a systematic review. 62
36366871 2022
5
Eczema herpeticum vs dermatitis herpetiformis as a clue of dedicator of cytokinesis 8 deficiency diagnosis: A case report. 62
36312485 2022
6
An integrated analysis of herpes virus infections from eight randomized clinical studies of baricitinib in adults with moderate-to-severe atopic dermatitis. 62
35490395 2022
7
Allergic conjunctivitis: a risk factor for recurrent herpes simplex virus infections in patients with atopic dermatitis 62
36468732 2022
8
Signaling sphingolipids are biomarkers for atopic dermatitis prone to disseminated viral infections. 62
35304160 2022
9
Facial Eczema Herpeticum. 62
35716717 2022
10
Correction: Extensive eczema herpeticum in a previously well child. 62
35650531 2022
11
Eczema herpeticum in atopic dermatitis. 62
35331549 2022
12
Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics. 62
35170821 2022
13
Evaluation of Atopic Dermatitis and Cutaneous Infectious Disorders Using Sequential Pattern Mining: A Nationwide Population-Based Cohort Study. 62
35743492 2022
14
Extensive eczema herpeticum in a previously well child. 62
35597913 2022
15
Atopic Dermatitis and the Medications Used for its Management: Impact on Ocular Health. 62
35533031 2022
16
Eczema Herpeticum Following Skin Microneedling Plus Platelet-Rich Plasma Therapy in a Patient with Atrophic Acne Scars. 62
35444444 2022
17
Complete blood count profiles in children with eczema herpeticum. 62
34379818 2022
18
Eczema Herpeticum in an Infant. 62
34503938 2021
19
Systemic antiviral dosing in eczema herpeticum. 62
34192363 2021
20
Eczema herpeticum subsequent to septic shock in early pregnancy: a first case report. 62
34906081 2021
21
Safety considerations of systemic Janus kinase inhibitors in atopic dermatitis applications. 62
34462967 2021
22
Herpes simplex virus 1 proteins can induce skin inflammation in an atopic dermatitis-like mouse model. 62
33751678 2021
23
Eczema herpeticum in atopic dermatitis. 62
33844308 2021
24
Role of pro-inflammatory cytokines in the pathophysiology of herpes simplex virus superinfection in Darier's disease. 62
34355821 2021
25
Phototherapy for atopic eczema. 62
34709669 2021
26
Efficacy and Safety of Upadacitinib vs Dupilumab in Adults With Moderate-to-Severe Atopic Dermatitis: A Randomized Clinical Trial. 62
34347860 2021
27
Staphylococcal TSST-1 Association with Eczema Herpeticum in Humans. 62
34319127 2021
28
An Infant With Seborrhoeic Dermatitis and Eczema Herpeticum Complicated by a Generalized Infection. 62
34522478 2021
29
Whole genome sequencing identifies novel genetic mutations in patients with eczema herpeticum. 62
33548076 2021
30
Advances in atopic dermatitis. 62
34001568 2021
31
Eczema Herpeticum in children with burns. 62
33679925 2021
32
Pooled safety analysis of baricitinib in adult patients with atopic dermatitis from 8 randomized clinical trials. 62
32926462 2021
33
The infectious complications of atopic dermatitis. 62
32771354 2021
34
Eczema herpeticum. 62
34660201 2021
35
Visual Dermatology: Eczema Herpeticum. 62
32442019 2020
36
Eczema Herpeticum: Clinical and Pathophysiological Aspects. 62
31836943 2020
37
Eczema herpeticum in a patient With Hailey-Hailey disease confounded by coexistent psoriasis. 62
32717004 2020
38
Recurrent eczema herpeticum - a retrospective European multicenter study evaluating the clinical characteristics of eczema herpeticum cases in atopic dermatitis patients. 62
31733162 2020
39
Frequency and Clinical Features Associated With Eczema Herpeticum in Hospitalized Children With Presumed Atopic Dermatitis Skin Infection. 62
31764378 2020
40
Bullous Pemphigoid in a Patient with Longstanding Hailey-Hailey Disease Complicated by Eczema Herpeticum: Managing the Coexistence of Three Different Blistering Conditions. 62
32308791 2020
41
Association of Atopic Dermatitis With Bacterial, Fungal, Viral, and Sexually Transmitted Skin Infections. 62
32049716 2020
42
Pediatric dermatology emergencies. 62
32352437 2020
43
Osteomyelitis complicating secondarily infected atopic eczema: two case reports and a narrative literature review. 62
32008574 2020
44
Eczema herpeticum: A medical emergency in patients with atopic dermatitis. 62
32226756 2020
45
Disseminated bullous impetigo and atopic dermatitis: Case series and literature review. 62
31755570 2020
46
IgE reactivity against herpes simplex virus 1 in patients with atopic dermatitis complicated by eczema herpeticum. 62
31315153 2020
47
Eczema herpeticum emerging during atopic dermatitis in infancy. 62
32558432 2020
48
Atopic dermatitis. 62
31690388 2019
49
Recurrent herpes labialis in the pediatric population: Prevalence, therapeutic studies, and associated complications. 62
31497896 2019
50
Seborrhea herpeticum: cutaneous herpes simplex virus infection within infantile seborrheic dermatitis. 62
31886781 2019

Variations for Eczema Herpeticum

Expression for Eczema Herpeticum

Search GEO for disease gene expression data for Eczema Herpeticum.

Pathways for Eczema Herpeticum

GO Terms for Eczema Herpeticum

Cellular components related to Eczema Herpeticum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.03 TSLP SPINK5 IL4 IL31 IL13 IGHE
2 keratohyalin granule GO:0036457 9.46 FLG2 FLG
3 cornified envelope GO:0001533 9.28 LORICRIN IVL FLG2 FLG CDSN

Biological processes related to Eczema Herpeticum according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 10.13 CAMP DEFB103A DEFB103B DEFB4A IGHE
2 defense response to Gram-positive bacterium GO:0050830 10.08 DEFB4A DEFB103B DEFB103A CAMP
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 10.01 TSLP IL4 IL13
4 positive chemotaxis GO:0050918 10 DEFB4A DEFB103B DEFB103A
5 positive regulation of interleukin-10 production GO:0032733 9.99 TSLP IL4 IL13
6 killing of cells of another organism GO:0031640 9.97 DEFB103A DEFB103B DEFB4A
7 peptide cross-linking GO:0018149 9.88 LORICRIN IVL FLG
8 cell chemotaxis GO:0060326 9.86 CCR6 DEFB103A DEFB103B DEFB4A
9 positive regulation of mast cell degranulation GO:0043306 9.85 IL4 IL13
10 microglial cell activation GO:0001774 9.8 IL4 IL13 IFNGR1
11 defense response GO:0006952 9.76 DEFB4A DEFB103B DEFB103A CAMP
12 keratinocyte differentiation GO:0030216 9.7 LORICRIN IVL FLG CDSN
13 negative regulation of complement-dependent cytotoxicity GO:1903660 9.67 IL4 IL13
14 killing by host of symbiont cells GO:0051873 9.43 DEFB103B DEFB103A CAMP
15 defense response to Gram-negative bacterium GO:0050829 9.28 TSLP DEFB4A DEFB103B DEFB103A CAMP

Molecular functions related to Eczema Herpeticum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.63 DEFB4A DEFB103B DEFB103A
2 cytokine receptor binding GO:0005126 9.26 IL4 IL31 IL13
3 CCR6 chemokine receptor binding GO:0031731 9.1 DEFB4A DEFB103B DEFB103A

Sources for Eczema Herpeticum

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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