Eczema Herpeticum disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology: ¹¹ A herpes simplex that results in infection located in skin, effected by preexisting dermatosis, has material basis in Human herpesvirus 1 or Human herpesvirus 2. The infection has symptom watery blisters, has symptom fever, and has symptom swelling of the lymph nodes.

MalaCards based summary: Eczema Herpeticum, also known as herpes simplex eyelid dermatitis, is related to molluscum contagiosum and chickenpox, and has symptoms including fever, watery blisters and swelling of the lymph nodes. An important gene associated with Eczema Herpeticum is ADSS2 (Adenylosuccinate Synthase 2), and among its related pathways/superpathways are Innate Immune System and Keratinization. The drugs Meticillin and Omalizumab have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and bone marrow, and related phenotypes are immune system and hematopoietic system

Wikipedia: ⁷⁵ Eczema herpeticum is a rare but severe disseminated infection that generally occurs at sites of skin... more...

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Related Diseases for Eczema Herpeticum

Diseases related to Eczema Herpeticum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 258)

#	Related Disease	Score	Top Affiliating Genes
1	molluscum contagiosum	30.6	LORICRIN IVL FLG
2	chickenpox	30.6	IL4 DOCK8 CCR6
3	blepharitis	30.5	IL4 IL13 CCR6
4	keratosis	30.5	LORICRIN IVL FLG
5	sezary's disease	30.5	IL4 IL31 CCR6
6	dermatitis	30.4	TSLP SPINK5 LORICRIN IVL IL4 IL31
7	epidermolysis bullosa	30.4	LORICRIN IVL FLG
8	epidermolysis bullosa simplex	30.4	LORICRIN IVL FLG
9	pemphigoid	30.3	IL4 IL31 IL13
10	chronic rhinitis	30.2	IL4 IL13
11	conjunctivitis	30.2	IL4 IL13 IGHE
12	common cold	30.2	TSLP IL4 IL13 CCR6
13	psoriasis 1	30.1	CDSN CCR6
14	celiac disease 1	30.1	TSLP IL4 IL13 CCR6
15	bullous pemphigoid	30.1	IVL IL4 IGHE
16	hypereosinophilic syndrome	30.1	IL4 IL13 IGHE
17	folliculitis	30.1	IL4 DEFB4A CCR6
18	ichthyosis	30.0	SPINK5 LORICRIN IVL FLG
19	scabies	30.0	IL4 IL31 IL13 FLG CCR6
20	food allergy	30.0	TSLP IL4 IL13 IGHE FLG CCR6
21	seborrheic dermatitis	29.9	SPINK5 LORICRIN FLG DEFB4A CCR6
22	dermatophytosis	29.9	DEFB4A CCR6 CAMP
23	rhinitis	29.8	TSLP IL4 IL13 IGHE FLG
24	allergic disease	29.6	TSLP IL4 IL13 IGHE FLG CCR6
25	fungal infectious disease	29.4	IL4 IL13 DOCK8 DEFB4A CCR6
26	ichthyosis vulgaris	29.2	TSLP SPINK5 LORICRIN IVL FLG2 FLG
27	autosomal recessive congenital ichthyosis	29.0	SPINK5 LORICRIN IVL FLG DEFB4A CDSN
28	contact dermatitis	28.6	TSLP SPINK5 LORICRIN IVL IL4 IL31
29	dermatitis, atopic	28.1	TSLP SPINK5 LORICRIN IVL IL4 IL31
30	skin disease	27.9	TSLP SPINK5 LORICRIN IVL IL4 IL31
31	psoriasis	27.7	SPINK5 LORICRIN IVL IL4 IL31 IL13
32	herpes simplex	10.8
33	exanthem	10.6
34	darier-white disease	10.5
35	pemphigus	10.5
36	viral infectious disease	10.5
37	benign chronic pemphigus	10.4
38	dermatitis, atopic, 2	10.4
39	photoallergic dermatitis	10.3	FLG CCR6
40	occupational dermatitis	10.3	IL31 FLG
41	shrimp allergy	10.3	IL13 CCR6
42	adult-onset severe asthma	10.3	TSLP CCR6
43	eosinophilic gastritis	10.3	TSLP IL13
44	chromium allergic contact dermatitis	10.3	IL4 IL13
45	cardiomyopathy, familial hypertrophic, 12	10.3	DEFB103B DEFB103A
46	esophageal candidiasis	10.3	IL13 CCR6
47	thunderstorm triggered asthma	10.3	IL4 IL13
48	pemphigus vulgaris, familial	10.3
49	toxic shock syndrome	10.3
50	encephalitis	10.3

Graphical network of the top 20 diseases related to Eczema Herpeticum:

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Symptoms & Phenotypes for Eczema Herpeticum

Symptoms:

¹¹

• fever
• watery blisters

• swelling of the lymph nodes

MGI Mouse Phenotypes related to Eczema Herpeticum:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.83	ADSS2 CAMP CCR6 CDSN DEFB103A DEFB103B
2	hematopoietic system	MP:0005397	9.5	ADSS2 CAMP CCR6 CDSN DEFB103A DEFB103B

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Drugs & Therapeutics for Eczema Herpeticum

Drugs for Eczema Herpeticum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Meticillin

Approved, Investigational

61-32-5

6087

2

Omalizumab

Approved, Investigational

242138-07-4

3

interferons

4

Interferon-gamma

5

Immunoglobulins, Intravenous

6

Anti-Asthmatic Agents

7

Immunoglobulins

8

Immunoglobulin E

9

Anti-Allergic Agents

10

Respiratory System Agents

11

Antibodies

Interventional clinical trials:

#	Name	Status	NCT ID
1	Integrated Extreme Trait Analysis to Understand the Etiology of Eczema Herpeticum (ADRN-06)	Completed	NCT03038932
2	Risk Factors in Atopic Dermatitis for the Development of Eczema Herpeticum	Completed	NCT00438022
3	Pilot Study To Determine The Underlying Mechanisms For Infection And Colonization By Staphylococcus Aureus Of The Skin Of Atopic Dermatitis Subjects With And Without A History Of Eczema Herpeticum (ADVN MRSA 10)	Completed	NCT00822276
4	Genetics of Atopic Dermatitis - Eczema Herpeticum	Completed	NCT00515047
5	Investigation of Reduced Interferon Responses in Peripheral Blood Mononuclear Cells of Participants With Atopic Dermatitis and a History of Eczema Herpeticum (ADRN-01)	Completed	NCT01429311
6	Registry for the Atopic Dermatitis Research Network (ADRN-02)	Completed	NCT01494142
7	Investigate the Impact of Increased IgE on Innate Anti-herpes Simplex Virus 1 Responses in the Eczema Herpeticum Patients	Recruiting	NCT04060550
8	Role of Staphylococci on Cytokine and T Cell Profiles in the Pathogenesis of Atopic Dermatitis and Eczema Herpeticum	Recruiting	NCT04274348

Search NIH Clinical Center for Eczema Herpeticum

Cochrane evidence based reviews: kaposi varicelliform eruption

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Genetic Tests for Eczema Herpeticum

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Anatomical Context for Eczema Herpeticum

Organs/tissues related to Eczema Herpeticum:

FMA: Skin

MalaCards : Skin, T Cells, Bone Marrow, Breast, Lung, Bone

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Publications for Eczema Herpeticum

Articles related to Eczema Herpeticum:

(show top 50) (show all 315)

#	Title	Authors	PMID	Year
1	Molecular pathogenesis and clinical implications of eczema herpeticum. ⁵³ ⁶²	Bussmann C...Novak N	18620613	2008
2	Safety of tralokinumab in adult patients with moderate-to-severe atopic dermatitis: pooled analysis of five randomized, double-blind, placebo-controlled phase II and phase III trials. ⁶²	Simpson EL...Wollenberg A	36082590	2022
3	The Genetics of Eczema Herpeticum. ⁶²	Hodara E...Ong PY	36114947	2022
4	Biomarkers associated with the development of comorbidities in patients with atopic dermatitis: a systematic review. ⁶²	Broderick C...BIOMAP Consortium	36366871	2022
5	Eczema herpeticum vs dermatitis herpetiformis as a clue of dedicator of cytokinesis 8 deficiency diagnosis: A case report. ⁶²	Alshengeti A	36312485	2022
6	An integrated analysis of herpes virus infections from eight randomized clinical studies of baricitinib in adults with moderate-to-severe atopic dermatitis. ⁶²	Werfel T...Wollenberg A	35490395	2022
7	Allergic conjunctivitis: a risk factor for recurrent herpes simplex virus infections in patients with atopic dermatitis ⁶²	Salonen J...Salava A	36468732	2022
8	Signaling sphingolipids are biomarkers for atopic dermatitis prone to disseminated viral infections. ⁶²	Berdyshev E...Leung DYM	35304160	2022
9	Facial Eczema Herpeticum. ⁶²	Moustafa GA...Shinder R	35716717	2022
10	Correction: Extensive eczema herpeticum in a previously well child. ⁶²	Almoalem M...Alnoaimi S	35650531	2022
11	Eczema herpeticum in atopic dermatitis. ⁶²	Berna-Rico ED...Burgos-Blasco P	35331549	2022
12	Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics. ⁶²	Bosma AL...Middelkamp-Hup MA	35170821	2022
13	Evaluation of Atopic Dermatitis and Cutaneous Infectious Disorders Using Sequential Pattern Mining: A Nationwide Population-Based Cohort Study. ⁶²	Han JH...Lee JH	35743492	2022
14	Extensive eczema herpeticum in a previously well child. ⁶²	Almoalem M...Alnoaimi S	35597913	2022
15	Atopic Dermatitis and the Medications Used for its Management: Impact on Ocular Health. ⁶²	Beakes C...Briceno L	35533031	2022
16	Eczema Herpeticum Following Skin Microneedling Plus Platelet-Rich Plasma Therapy in a Patient with Atrophic Acne Scars. ⁶²	Wu R...Zhao H	35444444	2022
17	Complete blood count profiles in children with eczema herpeticum. ⁶²	Chan G...Ong PY	34379818	2022
18	Eczema Herpeticum in an Infant. ⁶²	Ding G...Li Z	34503938	2021
19	Systemic antiviral dosing in eczema herpeticum. ⁶²	Pender E...Griffin L	34192363	2021
20	Eczema herpeticum subsequent to septic shock in early pregnancy: a first case report. ⁶²	Furuya K...Ogita K	34906081	2021
21	Safety considerations of systemic Janus kinase inhibitors in atopic dermatitis applications. ⁶²	Chang PH...Yu Y	34462967	2021
22	Herpes simplex virus 1 proteins can induce skin inflammation in an atopic dermatitis-like mouse model. ⁶²	Novak N...Cabanillas B	33751678	2021
23	Eczema herpeticum in atopic dermatitis. ⁶²	Traidl S...Werfel T	33844308	2021
24	Role of pro-inflammatory cytokines in the pathophysiology of herpes simplex virus superinfection in Darier's disease. ⁶²	Yamamoto T...Aoyama Y	34355821	2021
25	Phototherapy for atopic eczema. ⁶²	Musters AH...Spuls PI	34709669	2021
26	Efficacy and Safety of Upadacitinib vs Dupilumab in Adults With Moderate-to-Severe Atopic Dermatitis: A Randomized Clinical Trial. ⁶²	Blauvelt A...Eyerich K	34347860	2021
27	Staphylococcal TSST-1 Association with Eczema Herpeticum in Humans. ⁶²	Schlievert PM...Leung DYM	34319127	2021
28	An Infant With Seborrhoeic Dermatitis and Eczema Herpeticum Complicated by a Generalized Infection. ⁶²	Karpierz K...Kuchar EP	34522478	2021
29	Whole genome sequencing identifies novel genetic mutations in patients with eczema herpeticum. ⁶²	Bin L...Mathias RA	33548076	2021
30	Advances in atopic dermatitis. ⁶²	Plant A...Ardern-Jones MR	34001568	2021
31	Eczema Herpeticum in children with burns. ⁶²	Naumeri F...Ahmad HM	33679925	2021
32	Pooled safety analysis of baricitinib in adult patients with atopic dermatitis from 8 randomized clinical trials. ⁶²	Bieber T...Janes J	32926462	2021
33	The infectious complications of atopic dermatitis. ⁶²	Wang V...Ong PY	32771354	2021
34	Eczema herpeticum. ⁶²	Branco EA...Ceia F	34660201	2021
35	Visual Dermatology: Eczema Herpeticum. ⁶²	Ladha MA...Hardin J	32442019	2020
36	Eczema Herpeticum: Clinical and Pathophysiological Aspects. ⁶²	Damour A...Bodet C	31836943	2020
37	Eczema herpeticum in a patient With Hailey-Hailey disease confounded by coexistent psoriasis. ⁶²	Shah VV...Tonkovic-Capin V	32717004	2020
38	Recurrent eczema herpeticum - a retrospective European multicenter study evaluating the clinical characteristics of eczema herpeticum cases in atopic dermatitis patients. ⁶²	Seegraber M...Wollenberg A	31733162	2020
39	Frequency and Clinical Features Associated With Eczema Herpeticum in Hospitalized Children With Presumed Atopic Dermatitis Skin Infection. ⁶²	Hemani SA...Cooley A	31764378	2020
40	Bullous Pemphigoid in a Patient with Longstanding Hailey-Hailey Disease Complicated by Eczema Herpeticum: Managing the Coexistence of Three Different Blistering Conditions. ⁶²	Calvao Da Silva JCM...Brites MM	32308791	2020
41	Association of Atopic Dermatitis With Bacterial, Fungal, Viral, and Sexually Transmitted Skin Infections. ⁶²	Ren Z...Silverberg JI	32049716	2020
42	Pediatric dermatology emergencies. ⁶²	Robinson SK...Kim W	32352437	2020
43	Osteomyelitis complicating secondarily infected atopic eczema: two case reports and a narrative literature review. ⁶²	Masuka JT...Mkhize Z	32008574	2020
44	Eczema herpeticum: A medical emergency in patients with atopic dermatitis. ⁶²	Vera-Kellet C...Hasbun C	32226756	2020
45	Disseminated bullous impetigo and atopic dermatitis: Case series and literature review. ⁶²	Mannschreck D...Cohen B	31755570	2020
46	IgE reactivity against herpes simplex virus 1 in patients with atopic dermatitis complicated by eczema herpeticum. ⁶²	Cabanillas B...Novak N	31315153	2020
47	Eczema herpeticum emerging during atopic dermatitis in infancy. ⁶²	Ertugrul A...Bostanci I	32558432	2020
48	Atopic dermatitis. ⁶²	Peters N...Peters AT	31690388	2019
49	Recurrent herpes labialis in the pediatric population: Prevalence, therapeutic studies, and associated complications. ⁶²	Ahluwalia J...Eichenfield LF	31497896	2019
50	Seborrhea herpeticum: cutaneous herpes simplex virus infection within infantile seborrheic dermatitis. ⁶²	Steadman L...Haggstrom A	31886781	2019

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Genes for Eczema Herpeticum

Genes related to Eczema Herpeticum (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	ADSS2	Adenylosuccinate Synthase 2	Protein Coding	8.08	DISEASES inferred ¹⁴
2	FLG	Filaggrin	Protein Coding	7.66	DISEASES inferred ¹⁴
3	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	7.19	DISEASES inferred ¹⁴ ¹⁴
4	TSLP	Thymic Stromal Lymphopoietin	Protein Coding	6.94	DISEASES inferred ¹⁴
5	IL31	Interleukin 31	Protein Coding	6.5	DISEASES inferred ¹⁴
6	IL13	Interleukin 13	Protein Coding	6.32	DISEASES inferred ¹⁴
7	LORICRIN	Loricrin Cornified Envelope Precursor Protein	Protein Coding	6.14	DISEASES inferred ¹⁴
8	DEFB103A	Defensin Beta 103A	Protein Coding	6.14	DISEASES inferred ¹⁴
9	DEFB103B	Defensin Beta 103B	Protein Coding	6.14	DISEASES inferred ¹⁴
10	CAMP	Cathelicidin Antimicrobial Peptide	Protein Coding	6.12	DISEASES inferred ¹⁴
11	IL4	Interleukin 4	Protein Coding	6.02	DISEASES inferred ¹⁴
12	SPINK5	Serine Peptidase Inhibitor Kazal Type 5	Protein Coding	6	DISEASES inferred ¹⁴
13	DOCK8	Dedicator Of Cytokinesis 8	Protein Coding	5.94	DISEASES inferred ¹⁴
14	IVL	Involucrin	Protein Coding	5.9	DISEASES inferred ¹⁴
15	FLG2	Filaggrin 2	Protein Coding	5.86	DISEASES inferred ¹⁴
16	CDSN	Corneodesmosin	Protein Coding	5.66	DISEASES inferred ¹⁴
17	IFNGR1	Interferon Gamma Receptor 1	Protein Coding	5.58	DISEASES inferred ¹⁴
18	DEFB4A	Defensin Beta 4A	Protein Coding	5.58	DISEASES inferred ¹⁴
19	IGHE	Immunoglobulin Heavy Constant Epsilon	Protein Coding	5.5	Novoseek inferred ⁵³	18620613

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Variations for Eczema Herpeticum

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Expression for Eczema Herpeticum

Search GEO for disease gene expression data for Eczema Herpeticum.

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Pathways for Eczema Herpeticum

Pathways related to Eczema Herpeticum according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.62	TSLP IL4 IL31 IL13 IFNGR1 FLG2
2	Keratinization ⁶⁶ Show member pathways Formation of the cornified envelope ⁶⁶	12.19	SPINK5 LORICRIN IVL FLG CDSN
3	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.38	IL4 IL13 IFNGR1
4	Defensins ⁶⁶ Show member pathways Alpha-defensins ⁶⁶ Antimicrobial peptides ⁶⁶ Beta defensins ⁶⁶ Ion influx/efflux at host-pathogen interface ⁶⁶ Metal sequestration by antimicrobial proteins ⁶⁶	11.33	DEFB4A DEFB103B DEFB103A CCR6 CAMP
5	Non-genomic actions of 1,25 dihydroxyvitamin D3 ⁷⁴	11.29	IFNGR1 DEFB4A CAMP
6	Th2 Differentiation ⁶⁵	11.21	IL4 IL31 IL13
7	Innate Lymphoid Cells Differentiation ⁶⁵	11.16	TSLP IL4 IL13 CCR6
8	Development and heterogeneity of the ILC family ⁷⁴	10.84	TSLP IL4 IL13
9	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	10.54	IL4 IL13

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GO Terms for Eczema Herpeticum

Cellular components related to Eczema Herpeticum according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	10.03	TSLP SPINK5 IL4 IL31 IL13 IGHE
2	keratohyalin granule	GO:0036457	9.46	FLG2 FLG
3	cornified envelope	GO:0001533	9.28	LORICRIN IVL FLG2 FLG CDSN

Biological processes related to Eczema Herpeticum according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	defense response to bacterium	GO:0042742	10.13	CAMP DEFB103A DEFB103B DEFB4A IGHE
2	defense response to Gram-positive bacterium	GO:0050830	10.08	DEFB4A DEFB103B DEFB103A CAMP
3	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	10.01	TSLP IL4 IL13
4	positive chemotaxis	GO:0050918	10	DEFB4A DEFB103B DEFB103A
5	positive regulation of interleukin-10 production	GO:0032733	9.99	TSLP IL4 IL13
6	killing of cells of another organism	GO:0031640	9.97	DEFB103A DEFB103B DEFB4A
7	peptide cross-linking	GO:0018149	9.88	LORICRIN IVL FLG
8	cell chemotaxis	GO:0060326	9.86	CCR6 DEFB103A DEFB103B DEFB4A
9	positive regulation of mast cell degranulation	GO:0043306	9.85	IL4 IL13
10	microglial cell activation	GO:0001774	9.8	IL4 IL13 IFNGR1
11	defense response	GO:0006952	9.76	DEFB4A DEFB103B DEFB103A CAMP
12	keratinocyte differentiation	GO:0030216	9.7	LORICRIN IVL FLG CDSN
13	negative regulation of complement-dependent cytotoxicity	GO:1903660	9.67	IL4 IL13
14	killing by host of symbiont cells	GO:0051873	9.43	DEFB103B DEFB103A CAMP
15	defense response to Gram-negative bacterium	GO:0050829	9.28	TSLP DEFB4A DEFB103B DEFB103A CAMP

Molecular functions related to Eczema Herpeticum according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chemoattractant activity	GO:0042056	9.63	DEFB4A DEFB103B DEFB103A
2	cytokine receptor binding	GO:0005126	9.26	IL4 IL31 IL13
3	CCR6 chemokine receptor binding	GO:0031731	9.1	DEFB4A DEFB103B DEFB103A

Sources

Sources for Eczema Herpeticum

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ECZ002 MIFTS: 44	Eczema Herpeticum Categories: Eye diseases, Infectious diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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