MCID: ECZ002
MIFTS: 45

Eczema Herpeticum

Categories: Eye diseases, Infectious diseases, Skin diseases

Aliases & Classifications for Eczema Herpeticum

MalaCards integrated aliases for Eczema Herpeticum:

Name: Eczema Herpeticum 12 54 15 71 32
Herpes Simplex Eyelid Dermatitis 12 71
Kaposi Varicelliform Eruption 43 71
Herpes Simplex Dermatitis 12 71
Herpes Simplex Virus Eyelid Dermatitis 12
Herpes Simplex Dermatitis of Eyelid 12
Herpes Simplex Virus Dermatitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9123
ICD9CM 34 054.0 054.41
MeSH 43 D007617
NCIt 49 C35620
SNOMED-CT 67 186535001 186544000
ICD10 32 B00.0
UMLS 71 C0022504 C0153037 C0854331 more

Summaries for Eczema Herpeticum

Disease Ontology : 12 A herpes simplex that results in infection located in skin, effected by preexisting dermatosis, has material basis in Human herpesvirus 1 or Human herpesvirus 2. The infection has symptom watery blisters, has symptom fever, and has symptom swelling of the lymph nodes.

MalaCards based summary : Eczema Herpeticum, also known as herpes simplex eyelid dermatitis, is related to dermatitis and food allergy, and has symptoms including fever, watery blisters and swelling of the lymph nodes. An important gene associated with Eczema Herpeticum is FLG (Filaggrin), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Formaldehyde and Omalizumab have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and t cells, and related phenotypes are hematopoietic system and immune system

Wikipedia : 74 Eczema herpeticum is a rare but severe disseminated infection that generally occurs at sites of skin... more...

Related Diseases for Eczema Herpeticum

Diseases related to Eczema Herpeticum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)
# Related Disease Score Top Affiliating Genes
1 dermatitis 31.4 TSLP IL4 IFNG FLG CCR6
2 food allergy 30.8 IL4 IFNG FLG
3 interferon gamma, receptor 1, deficiency 30.8 IFNGR1 IFNG
4 keratoconjunctivitis 30.8 TSLP IL4 IFNG
5 contact dermatitis 30.8 IL4 IFNG FLG
6 skin disease 30.4 IL4 IFNG FLG CCR6 CAMP
7 toxic shock syndrome 30.4 IL4 IFNG CAMP
8 folliculitis 30.4 IL4 IFNG CCR6
9 rhinitis 30.3 TSLP IL4 IFNG FLG
10 common cold 30.2 TSLP IL4 CCR6
11 bacterial infectious disease 30.0 IRF3 IFNG CCR6 CAMP
12 dermatitis, atopic 29.9 TSLP IL4 IFNG FLG DEFB103A CRLF2
13 lymphopenia 29.7 IL7R IL4 IFNG CCR6
14 seborrheic dermatitis 29.6 FLG DOCK8 CCR6
15 chickenpox 29.6 IL4 IFNG DOCK8 CCR6
16 mycosis fungoides 29.6 IL4 IFNG CCR6
17 herpes simplex 11.0
18 exanthem 10.6
19 pemphigus 10.5
20 dermatitis, atopic, 3 10.5 TSLP FLG
21 benign chronic pemphigus 10.4
22 neurodermatitis 10.4 IL4 FLG
23 guttate psoriasis 10.4 IFNG CAMP
24 b-cell growth factor 10.4 IL4 IFNG
25 molluscum contagiosum 10.4
26 irritant dermatitis 10.4 TSLP IL4 FLG
27 atopic keratoconjunctivitis 10.3 IL4 IFNG
28 trichinosis 10.3 TSLP IL4 CRLF2
29 kimura disease 10.3 TSLP IL4 CRLF2
30 intrinsic asthma 10.3 TSLP IL4
31 orofacial granulomatosis 10.3 IL4 IFNG FLG
32 pemphigus vulgaris, familial 10.3
33 acrodermatitis 10.3
34 impetigo 10.3
35 encephalitis 10.3
36 hypereosinophilic syndrome 10.3
37 gastroenteritis 10.3 TSLP IL4 IFNG
38 eales disease 10.3 IL4 IFNG
39 nut allergy 10.3 FLG CCR6
40 nickel allergic contact dermatitis 10.3 IL4 IFNG
41 penicillin allergy 10.3 IL4 IFNGR1 IFNG
42 spotted fever rickettsiosis 10.2 IFNG IDO1
43 lymphoblastic leukemia, acute, with lymphomatous features 10.2 IL7R CRLF2
44 allergic contact dermatitis 10.2 IL4 IFNG FLG
45 darier-white disease 10.2
46 epidermolysis bullosa simplex, generalized 10.2
47 keratosis 10.2
48 epidermolysis bullosa 10.2
49 epidermolysis bullosa simplex 10.2
50 blepharitis 10.2

Graphical network of the top 20 diseases related to Eczema Herpeticum:



Diseases related to Eczema Herpeticum

Symptoms & Phenotypes for Eczema Herpeticum

Symptoms:

12
  • fever
  • watery blisters
  • swelling of the lymph nodes

MGI Mouse Phenotypes related to Eczema Herpeticum:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.77 CAMP CCR6 CRLF2 DOCK8 IDO1 IFNG
2 immune system MP:0005387 9.44 CAMP CCR6 CRLF2 DOCK8 IDO1 IFNG

Drugs & Therapeutics for Eczema Herpeticum

Drugs for Eczema Herpeticum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Formaldehyde Approved, Vet_approved Early Phase 1 50-00-0 712
2
Omalizumab Approved, Investigational 242138-07-4
3 interferons
4 Interferon-gamma
5 methicillin
6 Vaccines
7 Immunologic Factors
8 Respiratory System Agents
9 Antibodies
10 Anti-Allergic Agents
11 Immunoglobulins, Intravenous
12 Anti-Asthmatic Agents
13 Immunoglobulin E
14 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Risk Factors in Atopic Dermatitis for the Development of Eczema Herpeticum Completed NCT00438022
2 Genetics of Atopic Dermatitis - Eczema Herpeticum Completed NCT00515047
3 Investigation of Reduced Interferon Responses in Peripheral Blood Mononuclear Cells of Participants With Atopic Dermatitis and a History of Eczema Herpeticum (ADRN-01) Completed NCT01429311
4 Registry for the Atopic Dermatitis Research Network (ADRN-02) Completed NCT01494142
5 Pilot Study To Determine The Underlying Mechanisms For Infection And Colonization By Staphylococcus Aureus Of The Skin Of Atopic Dermatitis Subjects With And Without A History Of Eczema Herpeticum (ADVN MRSA 10) Completed NCT00822276
6 A Randomized Open Label Mechanistic Study in Atopic Dermatitis to Assess the Immunogenicity of Fluzone® Intradermal and Intramuscular Vaccines Completed NCT01737710
7 An Open Label Study in Adults With Atopic Dermatitis to Assess Variability in Immune Response to Fluzone® Intradermal Vaccine Completed NCT01518478 Early Phase 1 Fluzone® Intradermal (Sanofi Pasteur Inc.)
8 Investigate the Impact of Increased IgE on Innate Anti-herpes Simplex Virus 1 Responses in the Eczema Herpeticum Patients Recruiting NCT04060550
9 Integrated Extreme Trait Analysis to Understand the Etiology of Eczema Herpeticum (ADRN-06) Recruiting NCT03038932
10 Role of Staphylococci on Cytokine and T Cell Profiles in the Pathogenesis of Atopic Dermatitis and Eczema Herpeticum Not yet recruiting NCT04274348

Search NIH Clinical Center for Eczema Herpeticum

Cochrane evidence based reviews: kaposi varicelliform eruption

Genetic Tests for Eczema Herpeticum

Anatomical Context for Eczema Herpeticum

The Foundational Model of Anatomy Ontology organs/tissues related to Eczema Herpeticum:

19
Skin

MalaCards organs/tissues related to Eczema Herpeticum:

40
Skin, Lymph Node, T Cells, Colon, Testes, Bone Marrow, Bone

Publications for Eczema Herpeticum

Articles related to Eczema Herpeticum:

(show top 50) (show all 298)
# Title Authors PMID Year
1
Molecular pathogenesis and clinical implications of eczema herpeticum. 54 61
18620613 2008
2
Recurrent eczema herpeticum - a retrospective European multicenter study evaluating the clinical characteristics of eczema herpeticum cases in atopic dermatitis patients. 61
31733162 2020
3
Visual Dermatology: Eczema Herpeticum. 61
32442019 2020
4
Kaposi Varicelliform Eruption Associated With Chickenpox in a Liver Transplant Recipient. 61
29957162 2020
5
Frequency and Clinical Features Associated With Eczema Herpeticum in Hospitalized Children With Presumed Atopic Dermatitis Skin Infection. 61
31764378 2020
6
Association of Atopic Dermatitis With Bacterial, Fungal, Viral, and Sexually Transmitted Skin Infections. 61
32049716 2020
7
Bullous Pemphigoid in a Patient with Longstanding Hailey-Hailey Disease Complicated by Eczema Herpeticum: Managing the Coexistence of Three Different Blistering Conditions. 61
32308791 2020
8
Pediatric dermatology emergencies. 61
32352437 2020
9
Osteomyelitis complicating secondarily infected atopic eczema: two case reports and a narrative literature review. 61
32008574 2020
10
IgE reactivity against herpes simplex virus 1 in patients with atopic dermatitis complicated by eczema herpeticum. 61
31315153 2020
11
Eczema herpeticum emerging during atopic dermatitis in infancy. 61
32558432 2020
12
Eczema herpeticum: A medical emergency in patients with atopic dermatitis. 61
32226756 2020
13
Disseminated bullous impetigo and atopic dermatitis: Case series and literature review. 61
31755570 2020
14
Eczema Herpeticum: Clinical and Pathophysiological Aspects. 61
31836943 2019
15
Punched-out erosions with scalloped borders: Group A Streptococcal pustulosis. 61
31410890 2019
16
Seborrhea herpeticum: cutaneous herpes simplex virus infection within infantile seborrheic dermatitis. 61
31886781 2019
17
Atopic dermatitis. 61
31690388 2019
18
Recurrent herpes labialis in the pediatric population: Prevalence, therapeutic studies, and associated complications. 61
31497896 2019
19
Bilateral corneal geographic ulcers in a patient with eczema herpeticum. 61
31063273 2019
20
Hailey-Hailey Disease with Superimposed Eczema Herpeticum Caused by Herpes Simplex Virus Type 2 Infection in a Burn Unit: A Case Report and Literature Review. 61
31777694 2019
21
Concurrence of Acrodermatitis Enteropathica and Eczema Herpeticum in a Child with Atopic Dermatitis. 61
31607883 2019
22
Replicated methylation changes associated with eczema herpeticum and allergic response. 61
31443688 2019
23
Infections in Dupilumab Clinical Trials in Atopic Dermatitis: A Comprehensive Pooled Analysis. 61
31066001 2019
24
Disseminated zoster in an adult patient with extensive burns: a case report. 61
31122255 2019
25
Darier disease with disseminated herpes simplex virus type 2 infection. 61
31046908 2019
26
Kaposi varicelliform eruption induced by methotrexate in an adult atopic dermatitis patient. 61
30659717 2019
27
Antibiotic choice and methicillin-resistant Staphylococcus aureus rate in children hospitalized for atopic dermatitis. 61
30529713 2019
28
[Infantile atypical hand-foot-mouth disease with features of eczema herpeticum and acrodermatitis]. 61
30652458 2019
29
An 8-Month-Old Girl With Vesicular Rash. 61
30956997 2019
30
Eczema herpeticum in Darier's disease: a topical storm. 61
31528287 2019
31
Loss of ATP2A2 Allows Herpes Simplex Virus 1 Infection of a Human Epidermis Model by Disrupting Innate Immunity and Barrier Function. 61
29870688 2018
32
Atypical Varicella-Zoster Kaposi Varicelliform Eruption in Sézary Syndrome. 61
30211729 2018
33
Common features of atopic dermatitis with hypoproteinemia. 61
30304908 2018
34
Skin diseases associated with atopic dermatitis. 61
30217275 2018
35
Ivacaftor treatment of cystic fibrosis in children aged 12 to <24 months and with a CFTR gating mutation (ARRIVAL): a phase 3 single-arm study. 61
29886024 2018
36
A case of Kaposi varicelliform eruption progressing to herpes simplex virus hepatitis in an immunocompetent patient. 61
29446473 2018
37
Dermatology emergencies: handy hints for the acute medical team. 61
29995550 2018
38
Ankyrin repeat domain 1 regulates innate immune responses against herpes simplex virus 1: A potential role in eczema herpeticum. 61
29371118 2018
39
Quantitation of peptides from non-invasive skin tapings using isotope dilution and tandem mass spectrometry. 61
29601982 2018
40
Atypical Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6 in Denmark: A Diagnostic Mimicker. 61
29182793 2018
41
Disseminated herpes simplex virus: a case of eczema herpeticum causing viral encephalitis. 61
29741524 2018
42
Patients with atopic dermatitis and history of eczema herpeticum elicit herpes simplex virus-specific type 2 immune responses. 61
29155096 2018
43
Epidemiology of Eczema Herpeticum in Hospitalized U.S. Children: Analysis of a Nationwide Cohort. 61
28927889 2018
44
Risk of infection in patients with atopic dermatitis treated with dupilumab: A meta-analysis of randomized controlled trials. 61
28987493 2018
45
Association between atopic dermatitis and serious cutaneous, multiorgan and systemic infections in US adults. 61
29273131 2018
46
Herpeticum-like rash in a child with atopic dermatitis: early clinical suspicion is valuable. 61
30799900 2018
47
[A man with severe skin rash]. 61
29328012 2018
48
Characterization of children with recurrent eczema herpeticum and response to treatment with interferon-gamma. 61
29144049 2017
49
Not all that vesicles is herpes. 61
29536938 2017
50
[Acute skin infections and their imitators in children : A photo quiz]. 61
28914333 2017

Variations for Eczema Herpeticum

Expression for Eczema Herpeticum

Search GEO for disease gene expression data for Eczema Herpeticum.

Pathways for Eczema Herpeticum

Pathways related to Eczema Herpeticum according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 IRF7 IRF3 IRF2 IL7R IL4 IFNGR1
2
Show member pathways
13.16 IRF7 IRF3 IRF2 IL7R IL4 IFNGR1
3
Show member pathways
12.35 IRF7 IRF3 IRF2 IFNG
4
Show member pathways
12.21 IRF7 IRF3 IRF2 IFNGR1 IFNG
5 12.05 IRF7 IRF3 DEFB103A CAMP
6
Show member pathways
12.03 TSLP IL7R IL4 IFNGR1 IFNG CRLF2
7
Show member pathways
12.01 IRF7 IRF3 IRF2 IL4 IFNG
8 11.95 IRF7 IRF3 IRF2 IL4 IFNG IDO1
9 11.93 IRF7 IRF3 IRF2 DOCK8
10 11.8 IL7R IL4 IFNG
11 11.57 IRF2 IL7R IFNG
12 11.33 TSLP IL7R CRLF2
13 11.3 IL4 IFNG CRLF2
14 11.11 IRF2 IFNGR1 IFNG
15 11 TSLP IL7R IL4 IFNG CRLF2 CCR6
16 10.94 TSLP IL4 IFNG
17 10.87 IFNG ANKRD1

GO Terms for Eczema Herpeticum

Biological processes related to Eczema Herpeticum according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 defense response to virus GO:0051607 9.83 IRF7 IRF3 IRF2 IFNG
2 response to virus GO:0009615 9.8 IRF7 IFNGR1 IFNG
3 positive regulation of cell proliferation GO:0008284 9.73 TSLP IL7R IL4 IFNG CRLF2 CAMP
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.72 TSLP IL4 IFNG
5 type I interferon signaling pathway GO:0060337 9.71 IRF7 IRF3 IRF2
6 positive regulation of amyloid-beta formation GO:1902004 9.63 IFNGR1 IFNG
7 astrocyte activation GO:0048143 9.63 IFNGR1 IFNG
8 regulation of type I interferon production GO:0032479 9.62 IRF7 IRF3
9 positive regulation of type I interferon-mediated signaling pathway GO:0060340 9.61 IRF7 IRF3
10 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.61 IFNGR1 IFNG
11 positive regulation of chemokine biosynthetic process GO:0045080 9.6 IL4 IFNG
12 positive regulation of interferon-alpha production GO:0032727 9.59 IRF7 IRF3
13 negative regulation of amyloid-beta clearance GO:1900222 9.58 IFNGR1 IFNG
14 killing by host of symbiont cells GO:0051873 9.58 DEFB103A CAMP
15 positive regulation of MHC class II biosynthetic process GO:0045348 9.57 IL4 IFNG
16 positive regulation of interleukin-13 production GO:0032736 9.56 TSLP IL4
17 interleukin-7-mediated signaling pathway GO:0038111 9.54 TSLP IL7R CRLF2
18 positive regulation of interleukin-5 secretion GO:2000664 9.51 TSLP CRLF2
19 microglial cell activation GO:0001774 9.5 IL4 IFNGR1 IFNG
20 positive regulation of cellular respiration GO:1901857 9.49 IL4 IFNG
21 neuroinflammatory response GO:0150076 9.48 IL4 IFNG
22 positive regulation of mast cell activation GO:0033005 9.46 TSLP CRLF2
23 type I interferon biosynthetic process GO:0045351 9.43 IRF7 IRF3
24 MDA-5 signaling pathway GO:0039530 9.4 IRF7 IRF3
25 negative regulation of T cell apoptotic process GO:0070233 9.33 IL7R IDO1 DOCK8
26 positive regulation of STAT cascade GO:1904894 9.13 TSLP IL7R CRLF2
27 interferon-gamma-mediated signaling pathway GO:0060333 9.02 IRF7 IRF3 IRF2 IFNGR1 IFNG

Molecular functions related to Eczema Herpeticum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor activity GO:0004896 8.8 IL7R IFNGR1 CRLF2

Sources for Eczema Herpeticum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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