ES22
MCID: EGS001
MIFTS: 20

Egasyn (ES22)

Aliases & Classifications for Egasyn

MalaCards integrated aliases for Egasyn:

Name: Egasyn 57
Esterase 22; Es22 57
Esterase 22 57
Es22 57

External Ids:

OMIM 57 129905

Summaries for Egasyn

MalaCards based summary : Egasyn, is also known as esterase 22; es22. An important gene associated with Egasyn is CES1 (Carboxylesterase 1), and among its related pathways/superpathways is Drug metabolism - cytochrome P450. The drugs Tacrolimus and Calcineurin Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include liver and kidney, and related phenotype is adipose tissue.

Description from OMIM: 129905

Related Diseases for Egasyn

Symptoms & Phenotypes for Egasyn

Clinical features from OMIM:

129905

MGI Mouse Phenotypes related to Egasyn:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 8.62 CES1 GUSB

Drugs & Therapeutics for Egasyn

Drugs for Egasyn (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
2 Calcineurin Inhibitors Phase 4
3 Immunosuppressive Agents Phase 4
4 Liver Extracts Phase 4
5
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943
6
Remifentanil Approved Phase 3 132875-61-7 60815
7
Bivalirudin Approved, Investigational Phase 3 128270-60-0 16129704
8
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
9
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
10 Analgesics Phase 3,Phase 1
11 Central Nervous System Depressants Phase 3,Phase 1
12 Peripheral Nervous System Agents Phase 3,Phase 1
13 Fibrinolytic Agents Phase 3,Phase 1
14 Analgesics, Opioid Phase 3
15 Anesthetics Phase 3
16 Anesthetics, General Phase 3
17 Anesthetics, Intravenous Phase 3
18 Hypnotics and Sedatives Phase 3
19 Narcotics Phase 3
20 Anticoagulants Phase 3
21 Antithrombin III Phase 3
22 Antithrombins Phase 3
23 calcium heparin Phase 3
24 Calcium, Dietary Phase 3
25 Hirudins Phase 3
26 HIV Protease Inhibitors Phase 3
27 Krestin Phase 3
28
protease inhibitors Phase 3
29 Serine Proteinase Inhibitors Phase 3
30 Histone Deacetylase Inhibitors Phase 1, Phase 2
31
Aspirin Approved, Vet_approved Phase 1 50-78-2 2244
32
Ethanol Approved Phase 1 64-17-5 702
33
Oseltamivir Approved Phase 1 204255-11-8, 196618-13-0 65028
34
Irinotecan Approved, Investigational Phase 1 97682-44-5, 100286-90-6 60838
35 Orange Approved, Nutraceutical Phase 1
36
Camptothecin Experimental Phase 1 7689-03-4
37 Analgesics, Non-Narcotic Phase 1
38 Anti-Infective Agents Phase 1
39 Anti-Infective Agents, Local Phase 1
40 Anti-Inflammatory Agents Phase 1
41 Anti-Inflammatory Agents, Non-Steroidal Phase 1
42 Antipyretics Phase 1
43 Antirheumatic Agents Phase 1
44 Antiviral Agents Phase 1
45 Cyclooxygenase Inhibitors Phase 1
46 Platelet Aggregation Inhibitors Phase 1
47 Adjuvants, Immunologic Phase 1,Not Applicable
48 Angiogenesis Inhibitors Phase 1
49 Angiogenesis Modulating Agents Phase 1
50 Interleukin-12 Phase 1

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 A Paediatric, Open, Follow up Study With Modigraf Examining Safety and Efficacy in de Novo Allograft Recipients Terminated NCT01371344 Phase 4 Tacrolimus granules;Tacrolimus
2 Low Remifentanil Target Controlled Infusions for Cardiac Surgery Recruiting NCT02033629 Phase 3 Ce 1 ng/ml;Ce 2 ng/ml;Ce 3 ng/ml
3 Comparison of Anticoagulation for All-comers Undergoing Percutaneous Coronary Revascularization Trial Terminated NCT02448550 Phase 3 Bivalirudin;Unfractionated heparin
4 Dose Escalation Trial of Tefinostat for Cancer Associated Inflamation in Hepatocellular Carcinoma (HCC) Active, not recruiting NCT02759601 Phase 1, Phase 2 Tefinostat
5 HIV-1-Gag Conserved-Element DNA Vaccine as Therapeutic Vaccination in HIV-Infected Persons With Viral Suppression on Antiretroviral Therapy Not yet recruiting NCT03560258 Phase 1, Phase 2
6 Alcohol Inhibits Drug Metabolism by Carboxylesterases Completed NCT01708369 Phase 1 Placebo;Ethanol;Oseltamivir;Aspirin
7 Evaluating the Safety and Immunogenicity of pDNA Vaccines Expressing HIV M Group p24^Gag Conserved Elements and/or p55^Gag, Administered With IL-12 pDNA by Intramuscular Electroporation, in Healthy, HIV-Uninfected Adults Recruiting NCT03181789 Phase 1
8 Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas Recruiting NCT02192359 Phase 1 irinotecan hydrochloride
9 Genetically Modified Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas Withdrawn NCT02055196 Phase 1 irinotecan hydrochloride
10 An Evaluation of the Spectra Optia CMNC Collection Procedure Completed NCT02253160 Not Applicable Granulocyte-colony stimulating factor (G-CSF)
11 MR Assessment of Hepatic Hydatid Disease Recruiting NCT03289884
12 Three M Study (Malabsorption, Microbiota, Mini-Gastric Bypass) Recruiting NCT03412149 Not Applicable

Search NIH Clinical Center for Egasyn

Genetic Tests for Egasyn

Anatomical Context for Egasyn

MalaCards organs/tissues related to Egasyn:

41
Liver, Kidney

Publications for Egasyn

Articles related to Egasyn:

(show all 20)
# Title Authors Year
1
Human egasyn binds beta-glucuronidase but neither the esterase active site of egasyn nor the C-terminus of beta-glucuronidase is involved in their interaction. ( 10562416 )
1999
2
Identification and androgen regulation of egasyn in the mouse epididymis. ( 9531973 )
1998
3
The beta-glucuronidase propeptide contains a serpin-related octamer necessary for complex formation with egasyn esterase and for retention within the endoplasmic reticulum. ( 7744842 )
1995
4
Cloning and sequencing of rat liver carboxylesterase ES-3 (egasyn). ( 7945287 )
1994
5
The signal for retention of the egasyn-glucuronidase complex within the endoplasmic reticulum. ( 8346916 )
1993
6
Characterization and functional expression of a cDNA encoding egasyn (esterase-22): the endoplasmic reticulum-targeting protein of beta-glucuronidase. ( 1783403 )
1991
7
Expression of egasyn-esterase in mammalian cells. Sequestration in the endoplasmic reticulum and complexation with beta-glucuronidase. ( 2007590 )
1991
8
Strain differences of rat liver carboxylesterase activities related to the phenotype difference of esterase-3 (egasyn). ( 2609020 )
1989
9
Egasyn affects the processing of beta-glucuronidase in mouse liver. ( 3214427 )
1988
10
Involvement of the esterase active site of egasyn in compartmentalization of beta-glucuronidase within the endoplasmic reticulum. ( 3594574 )
1987
11
An accessory protein identical to mouse egasyn is complexed with rat microsomal beta-glucuronidase and is identical to rat esterase-3. ( 3294829 )
1987
12
Lumenal location of the microsomal beta-glucuronidase-egasyn complex. ( 3667691 )
1987
13
Identity of esterase-22 and egasyn, the protein which complexes with microsomal beta-glucuronidase. ( 3729927 )
1986
14
The egasyn gene affects the processing of oligosaccharides of lysosomal beta-glucuronidase in liver. ( 3101673 )
1986
15
Egasyn, a protein which determines the subcellular distribution of beta-glucuronidase, has esterase activity. ( 4066695 )
1985
16
Preparation of microsomal beta-glucuronidase and its membrane anchor protein, egasyn. ( 6656645 )
1983
17
The synthesis and processing of beta-glucuronidase in normal and egasyn deficient mouse kidney. ( 7236294 )
1981
18
Inheritance in mice of the membrane anchor protein egasyn: the Eg locus determines egasyn levels. ( 849245 )
1977
19
Relationships between levels of membrane-bound glucuronidase and the associated protein egasyn in mouse tissues. ( 873997 )
1977
20
Isolation, characterization, and radioimmunoassay of murine egasyn, a protein stabilizing glucuronidase membrane binding. ( 826534 )
1976

Variations for Egasyn

Expression for Egasyn

Search GEO for disease gene expression data for Egasyn.

Pathways for Egasyn

GO Terms for Egasyn

Sources for Egasyn

3 CDC
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11 DGIdb
17 ExPASy
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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