ES22
MCID: EGS001
MIFTS: 13

Egasyn (ES22)

Aliases & Classifications for Egasyn

MalaCards integrated aliases for Egasyn:

Name: Egasyn 57
Esterase 22; Es22 57
Esterase 22 57
Es22 57

External Ids:

OMIM® 57 129905

Summaries for Egasyn

MalaCards based summary : Egasyn, is also known as esterase 22; es22. An important gene associated with Egasyn is CES1 (Carboxylesterase 1), and among its related pathways/superpathways is Drug metabolism - cytochrome P450. Affiliated tissues include liver and kidney, and related phenotype is adipose tissue.

More information from OMIM: 129905

Related Diseases for Egasyn

Symptoms & Phenotypes for Egasyn

Clinical features from OMIM®:

129905 (Updated 20-May-2021)

MGI Mouse Phenotypes related to Egasyn:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 8.62 CES1 GUSB

Drugs & Therapeutics for Egasyn

Search Clinical Trials , NIH Clinical Center for Egasyn

Genetic Tests for Egasyn

Anatomical Context for Egasyn

MalaCards organs/tissues related to Egasyn:

40
Liver, Kidney

Publications for Egasyn

Articles related to Egasyn:

(show all 37)
# Title Authors PMID Year
1
Characterization and functional expression of a cDNA encoding egasyn (esterase-22): the endoplasmic reticulum-targeting protein of beta-glucuronidase. 57 61
1783403 1991
2
Identity of esterase-22 and egasyn, the protein which complexes with microsomal beta-glucuronidase. 57 61
3729927 1986
3
Nonspecific esterases of Mus musculus. 57
7115289 1982
4
Distinct patterns of aging effects on the expression and activity of carboxylesterases in rat liver and intestine. 61
24271336 2014
5
Esterase 22 and beta-glucuronidase hydrolyze retinoids in mouse liver. 61
19723663 2009
6
Extremely sensitive biomarker of acute organophosphorus insecticide exposure. 61
16004201 2005
7
Organophosphates and their impact on the global environment. 61
10794404 2000
8
Human egasyn binds beta-glucuronidase but neither the esterase active site of egasyn nor the C terminus of beta-glucuronidase is involved in their interaction. 61
10562416 1999
9
Toxicological significance in the cleavage of esterase-beta-glucuronidase complex in liver microsomes by organophosphorus compounds. 61
10421485 1999
10
Identification and androgen regulation of egasyn in the mouse epididymis. 61
9531973 1998
11
Androgen regulation of molecular forms of beta-D-glucuronidase in the mouse epididymis: comparison with liver and kidney. 61
8792210 1996
12
Rat serum carboxylesterase. Cloning, expression, regulation, and evidence of secretion from liver. 61
7642579 1995
13
The beta-glucuronidase propeptide contains a serpin-related octamer necessary for complex formation with egasyn esterase and for retention within the endoplasmic reticulum. 61
7744842 1995
14
Cloning and sequencing of rat liver carboxylesterase ES-3 (egasyn). 61
7945287 1994
15
Heterogeneity of Wistar rats with respect to acid beta-D-glucuronidase (EC 3.2.1.31) in liver. 61
7951044 1994
16
The signal for retention of the egasyn-glucuronidase complex within the endoplasmic reticulum. 61
8346916 1993
17
The COOH terminus of several liver carboxylesterases targets these enzymes to the lumen of the endoplasmic reticulum. 61
1939102 1991
18
Expression of egasyn-esterase in mammalian cells. Sequestration in the endoplasmic reticulum and complexation with beta-glucuronidase. 61
2007590 1991
19
Release of liver microsomal beta-glucuronidase from hepatocytes in vitro and in vivo by organophosphates and hepatotoxic agents. 61
1920540 1991
20
beta-Glucuronidase is transported slowly to lysosomes in BW5147 mouse lymphoma cells: evidence that the prelysosomal enzyme is not restricted to the endoplasmic reticulum. 61
2221912 1990
21
The propeptide of beta-glucuronidase. Further evidence of its involvement in compartmentalization of beta-glucuronidase and sequence similarity with portions of the reactive site region of the serpin superfamily. 61
2394691 1990
22
Strain differences of rat liver carboxylesterase activities related to the phenotype difference of esterase-3 (egasyn). 61
2609020 1989
23
Involvement of the carboxyl-terminal propeptide of beta-glucuronidase in its compartmentalization within the endoplasmic reticulum as determined by a synthetic peptide approach. 61
2777765 1989
24
Egasyn affects the processing of beta-glucuronidase in mouse liver. 61
3214427 1988
25
Lumenal location of the microsomal beta-glucuronidase-egasyn complex. 61
3667691 1987
26
Involvement of the esterase active site of egasyn in compartmentalization of beta-glucuronidase within the endoplasmic reticulum. 61
3594574 1987
27
An accessory protein identical to mouse egasyn is complexed with rat microsomal beta-glucuronidase and is identical to rat esterase-3. 61
3294829 1987
28
The egasyn gene affects the processing of oligosaccharides of lysosomal beta-glucuronidase in liver. 61
3101673 1986
29
Egasyn, a protein which determines the subcellular distribution of beta-glucuronidase, has esterase activity. 61
4066695 1985
30
Preparation of microsomal beta-glucuronidase and its membrane anchor protein, egasyn. 61
6656645 1983
31
The synthesis and processing of beta-glucuronidase in normal and egasyn deficient mouse kidney. 61
7236294 1981
32
Demonstration of a rat liver microsomal binding protein specific for beta-glucuronidase. 61
438156 1979
33
Relationships between levels of membrane-bound glucuronidase and the associated protein egasyn in mouse tissues. 61
873997 1977
34
Inheritance in mice of the membrane anchor protein egasyn: the Eg locus determines egasyn levels. 61
849245 1977
35
Isolation, characterization, and radioimmunoassay of murine egasyn, a protein stabilizing glucuronidase membrane binding. 61
826534 1976
36
Phenobarbital induction of egasyn: availability of egasyn in vivo determines glucuronidase binding to membrane. 61
1267808 1976
37
Egasyn, a protein complexed with microsomal beta-glucuronidase. 61
1112792 1975

Variations for Egasyn

Expression for Egasyn

Search GEO for disease gene expression data for Egasyn.

Pathways for Egasyn

GO Terms for Egasyn

Sources for Egasyn

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....