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MCID: EGG001
MIFTS: 41

Egg Allergy

Categories: Immune diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Egg Allergy

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MalaCards integrated aliases for Egg Allergy:

Name: Egg Allergy 12 15 17
Egg Hypersensitivity 44
Allergy to Eggs 12
Allergies Egg 54

Classifications:

MalaCards categories:
Anatomical: Immune diseases
See all MalaCards categories (disease lists)


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Disease Ontology 12 DOID:4377
MeSH 44 D021181
SNOMED-CT 67 91930004
UMLS 71 C0559469
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Summaries for Egg Allergy

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Disease Ontology : 12 A food allergy that is an allergy or hypersensitivity to dietary substances from the yolk or whites of eggs, causing an overreaction of the immune system which may lead to severe physical symptoms.

MalaCards based summary : Egg Allergy, also known as egg hypersensitivity, is related to rubella and cytokine deficiency. An important gene associated with Egg Allergy is IGHE (Immunoglobulin Heavy Constant Epsilon), and among its related pathways/superpathways are Allograft rejection and T cell receptor signaling pathway. The drugs Vaccines and Immunoglobulin E have been mentioned in the context of this disorder. Affiliated tissues include skin, thymus and t cells, and related phenotypes are hematopoietic system and digestive/alimentary

Wikipedia : 74 Egg allergy is an immune hypersensitivity to proteins found in chicken eggs, and possibly goose, duck,... more...

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Related Diseases for Egg Allergy

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Diseases related to Egg Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 300)
# Related Disease Score Top Affiliating Genes
1 rubella 30.6 IL5 IL4 IL10
2 cytokine deficiency 30.2 IL5 IL13
3 ige responsiveness, atopic 30.1 IL5 IL4 IL13 IL10 IGHE
4 urticaria 30.1 IL5 IL4 IL13 IGHE ENPP3
5 diphtheria 29.9 IL5 IL4 IL13
6 food allergy 29.9 IL5 IL4 IL13 IL10 IGHE FOXP3
7 tetanus 29.8 IL5 IL4 IL13 IL10
8 cholera 29.8 IL5 IL4 IL10
9 chronic urticaria 29.7 IL4 IL13 IGHE ENPP3
10 cow milk allergy 29.7 LALBA IL5 IL4 IL10
11 hypereosinophilic syndrome 29.7 IL5 IL4 IL13 IL10 IGHE
12 milk allergy 29.6 LALBA IL5 IL4 IL13 IL10 IGHE
13 allergic rhinitis 29.6 IL5 IL4 IL13 IL10 IGHE
14 gastroenteritis 29.5 TSLP IL5 IL4 IL10
15 eosinophilic gastroenteritis 29.5 TSLP IL5 IL4 CCR6
16 allergic disease 29.5 TSLP IL5 IL4 IL13 FOXP3 CCR6
17 peanut allergy 29.4 PEDS1 IL5 IL4 IL13 IL10 IGHE
18 allergic conjunctivitis 29.2 IL5 IL4 IL13 IL10 IGHE FOXP3
19 arthritis 29.2 IL4 IL13 IL10 FOXP3 CCR6
20 conjunctivitis 29.1 IL5 IL4 IL13 IL10 IGHE FOXP3
21 autoimmune disease 29.0 IL5 IL4 IL13 IL10 FOXP3 CCR6
22 esophagitis, eosinophilic, 1 28.9 TSLP IL5 IL4 IL13 FLG CCR6
23 rheumatoid arthritis 28.9 IL4 IL13 IL10 FOXP3 FLG CCR6
24 rhinitis 28.9 TSLP IL5 IL4 IL13 IL10 IGHE
25 dermatitis 28.8 TSLP IL5 IL4 IL13 IL10 IGHE
26 dermatitis, atopic 28.7 TSLP LALBA IL5 IL4 IL13 IL10
27 esophagitis 28.7 TSLP IL5 IL4 IL13 IL10 FLG
28 nut allergy 28.6 PDCL IL5 IL4 IL13 IGHE FLG
29 asthma 28.3 TSLP IL5 IL4 IL13 IL10 IGHE
30 respiratory allergy 28.0 PDCL IL5 IL4 IL13 IL10 IGHE
31 chicken egg allergy 11.6
32 influenza 10.5
33 measles 10.4
34 mumps 10.4
35 acute asthma 10.3 IL5 IL4
36 amoxicillin allergy 10.3 IGHE ENPP3
37 childhood-onset asthma 10.3 IL13 IGHE
38 aztreonam allergy 10.3 IL5 IL13
39 crab allergy 10.3 IL5 ENPP3
40 cefaclor allergy 10.3 IL5 IL13
41 atopic keratoconjunctivitis 10.3 IL5 IL4 IGHE
42 toxic oil syndrome 10.3 IL5 IL4 IGHE
43 cefuroxime allergy 10.3 IL5 IL13
44 cough variant asthma 10.3 IL5 IL4 IGHE
45 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL5 IL13
46 yellow fever 10.3
47 vernal conjunctivitis 10.3 IL4 IGHE CCR6
48 respiratory syncytial virus infectious disease 10.3 IL5 IL13
49 pustulosis palmaris et plantaris 10.2 IL5 CCR6
50 immunodeficiency with hyper-igm, type 1 10.2 IL4 IGHE CCR6

Graphical network of the top 20 diseases related to Egg Allergy:



Diseases related to Egg Allergy
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Symptoms & Phenotypes for Egg Allergy

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MGI Mouse Phenotypes related to Egg Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 CCR6 COPS7A ENPP3 FOXP3 IL10 IL13
2 digestive/alimentary MP:0005381 9.8 ENPP3 FOXP3 IL10 IL13 IL4 IL5
3 immune system MP:0005387 9.65 CCR6 COPS7A ENPP3 FOXP3 IL10 IL13
4 respiratory system MP:0005388 9.17 ENPP3 FOXP3 IL10 IL13 IL4 IL5
Sources

Drugs & Therapeutics for Egg Allergy

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Drugs for Egg Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4
2 Immunoglobulin E
3 Immunoglobulins
4 Immunoglobulins, Intravenous
5 Antibodies

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Phase 4 Study to Assess the Safety of Nasal Influenza Immunisation in Egg Allergic Children - a Multicentre Observational Study Completed NCT02111512 Phase 4 Administration of Live attenuated influenza vaccine (LAIV)
2 Basophil Activation Test (BAT) Sensitivity in Child Food Allergy Completed NCT01966640 Phase 4
3 Flu Vaccine in Egg-allergic Patients Minimizing Injections Safety Trial Completed NCT01248208 Phase 1, Phase 2
4 Induction of Tolerance Through Early Introduction of Peanut in High-Risk Children (ITN032AD) Completed NCT00329784 Phase 2
5 Specific Oral Tolerance Induction in Children With Severe Egg Allergy: A Randomized Controlled Trial Using a 6 Months Protocol Completed NCT01379651 Phase 1, Phase 2
6 The Persistence of Oral Tolerance Induction to Peanut and Its Immunological Basis (ITN049AD) Completed NCT01366846 Phase 2
7 Phase 2 Study of AR201 Oral Immunotherapy for Desensitization in Children, Adolescents, and Young Adults With Hen Egg Allergy Active, not recruiting NCT04056299 Phase 2
8 Cow's Milk and Hen's Egg Hyposensitization in Adults Unknown status NCT02083471
9 Egg Oral Immunotherapy Completed NCT01489553
10 Potential Allergens in Wine: Double Blind Placebo-controlled Trial and Basophil Activation Analysis Completed NCT00163735 Administration of wine fined with potential food allergens
11 The Effect of Per Oral Immunotherapy in Severe IgE Mediated Egg, Milk and Nut Allergy in Adults Completed NCT01822353
12 Multi-Centered, Randomized, Placebo-Controlled Trial of the Safety of Influenza Vaccine in Egg Allergic Children With a History of Anaphylaxis or Severe Allergy to Egg Completed NCT01264601
13 Pilot Project on Clinical Tolerance to a Live Attenuated Vaccine Against Influenza (Flumist®) in the Context of Influenza Vaccination in a Population Allergic to Eggs. Completed NCT02142491
14 Treatment of Egg Allergy in Children Through Oral Desensitization (EGG OIT) Completed NCT00597558 Egg white protein
15 The Utility of Food-Specific IgE Measured With the IMMULITE 2000 Assay to Predict Symptomatic Food Allergy Completed NCT01950533
16 Phase 4 Study to Assess the Safety of Nasal Influenza Immunisation in Egg Allergic Children - a Multicentre Observational Study Completed NCT01859039
17 A Prospective Cohort Study of Immune Mechanisms, Genetic Factors, and Clinical and Environmental Characteristics Associated With the Occurrence and Clinical Outcome of Food Allergy (CoFAR2) Completed NCT00356174
18 The Effect of Per Oral Immunotherapy Treatment in Severe IgE Mediated Milk, Peanut and Egg Allergy in Adults Recruiting NCT03361072
19 Gradual Egg-tolerance Induction in Hen's Egg Allergic Children Who Tolerate Baked Egg (TETI-II Study) Recruiting NCT04677790
20 Basophil Activation Test to Diagnose Food Allergy Recruiting NCT03309488
21 Trapsgewijze Ei-tolerantie-inductie Bij Kippenei-allergische Kinderen (TETI Studie) Active, not recruiting NCT02487420

Search NIH Clinical Center for Egg Allergy

Cochrane evidence based reviews: egg hypersensitivity

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Genetic Tests for Egg Allergy

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Anatomical Context for Egg Allergy

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MalaCards organs/tissues related to Egg Allergy:

40
Skin, Thymus, T Cells
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Publications for Egg Allergy

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Articles related to Egg Allergy:

(show top 50) (show all 678)
# Title Authors PMID Year
1
Lipocalin-type prostaglandin D synthase and egg white cystatin react with IgE antibodies from children with egg allergy. 54 61
20179418 2010
2
Correlation between specific immunoglobulin E levels and the severity of reactions in egg allergic patients. 54 61
18257905 2008
3
The natural history of egg allergy. 61 54
18073126 2007
4
Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy. 54 61
17573723 2007
5
Detection of four distinct groups of hen egg allergens binding IgE in the sera of children with egg allergy. 61 54
16045855 2005
6
Determination of food specific IgE levels over time can predict the development of tolerance in cow's milk and hen's egg allergy. 54 61
15316521 2004
7
Possible modes of allergen-specific sensitization and boosting in an atopic child. 61 54
12740528 2003
8
Prediction of tolerance on the basis of quantification of egg white-specific IgE antibodies in children with egg allergy. 61 54
12170273 2002
9
Cellular immune responses to ovalbumin and house dust mite in egg-allergic children. 54 61
11906334 2002
10
Cytokine production in children outgrowing hen egg allergy. 54 61
8955579 1996
11
Establishment and characterization of ovalbumin-specific T cell lines from patients with egg allergy. 54 61
8634518 1996
12
Allergenic epitopes of ovalbumin (OVA) in patients with hen's egg allergy: inhibition of basophil histamine release by haptenic ovalbumin peptide. 54 61
8608645 1996
13
[IgE production and gene expression of interleukin-4 and interferon-gamma by peripheral mononuclear cells in asthmatic children]. 61 54
7726752 1995
14
Identification of the disease-related T cell epitope of ovalbumin and epitope-targeted T cell inactivation in egg allergy. 61 54
7522686 1994
15
Egg white-specific IgE level as a tolerance marker in the follow up of egg allergy. 54 61
8034192 1994
16
[The production of B cell stimulating activity in peripheral blood mononuclear cells from allergic children with positive IgE RAST score to egg white]. 54 61
2053859 1991
17
[Primary prevention of food allergy in childhood]. 61
33570030 2021
18
Infant Allergy Testing and Food Allergy Diagnoses Before and After Guidelines for Early Peanut Introduction. 61
33186769 2021
19
A Randomized, Open-Label Trial of Hen's Egg Oral Immunotherapy: Efficacy and Humoral Immune Responses in 50 Children. 61
33529723 2021
20
Home-based, slow up-dosing oral immunotherapy for hen's egg allergy in an adult patient. 61
33604272 2021
21
Successful sublingual immunotherapy for severe egg allergy in children: a case report. 61
33407837 2021
22
A Mouse Model of Oral Sensitization to Hen's Egg White. 61
33226586 2021
23
Efficacy, safety, and parental anxiety in a randomized trial of two dietary instruction methods for children with suspected hen's egg allergy. 61
32814667 2021
24
Risk factors of food sensitization in young children with atopic dermatitis. 61
33386793 2021
25
A Consensus Approach to the Primary Prevention of Food Allergy Through Nutrition: Guidance from the American Academy of Allergy, Asthma, and Immunology; American College of Allergy, Asthma, and Immunology; and the Canadian Society for Allergy and Clinical Immunology. 61
33250376 2021
26
Specific IgE levels as an outcome predictor in egg-allergic children. 61
33528933 2021
27
Agreement Between Predictive, Allergen-Specific IgE Values Assessed by ImmunoCAP and IMMULITE 2000 3gAllergy™ Assay Systems for Milk and Wheat Allergies. 61
33191682 2021
28
Detection of specific IgE against linear epitopes from Gal d 1 has additional value in diagnosing hen's egg allergy in adults. 61
32909666 2020
29
Behavior Change, Egg Consumption, and Child Nutrition: A Cluster Randomized Controlled Trial. 61
33239474 2020
30
Evaluation of baked egg oral immunotherapy in French children with hen's egg allergy. 61
33349960 2020
31
Investigation of Basophil Activation Test for Diagnosing Milk and Egg Allergy in Younger Children. 61
33291359 2020
32
Epidemiological study of food allergy in a population of Argentine children. 61
33231050 2020
33
An update on international practice variation in peanut introduction: conundrums, controversies, and a new direction. 61
33060444 2020
34
Allergy and immunology in young children of Japan: The JECS cohort. 61
33204389 2020
35
Safety of measles, mumps, and rubella vaccine in egg allergy: in vivo and in vitro management. 61
33292334 2020
36
A virtual management approach to infant egg allergy developed in response to pandemic-imposed restrictions. 61
33244828 2020
37
Baked egg tolerance: is it possible to predict? 61
31513760 2020
38
Utility of fresh egg skin prick test and egg yolk specific immunoglobulin E for outgrowth. 61
32526376 2020
39
Induction of sustained unresponsiveness after egg oral immunotherapy compared to baked egg therapy in children with egg allergy. 61
32535135 2020
40
Ovomucoid epitope-specific repertoire of IgE, IgG4 , IgG1 , IgA1 , and IgD antibodies in egg-allergic children. 61
32391917 2020
41
Egg yolk augments type 2 immunity by activating innate cells. 61
31903504 2020
42
Longitudinal egg-specific regulatory T- and B-cell development: Insights from primary prevention clinical trials examining the timing of egg introduction. 61
33040362 2020
43
Pediatric Allergic Diseases, Food Allergy, and Oral Tolerance. 61
32634325 2020
44
Preventing food allergy in infancy and childhood: Systematic review of randomised controlled trials. 61
32396244 2020
45
Egg Allergy in US Children. 61
32376485 2020
46
Safety of yellow fever vaccine administration in confirmed egg-allergic patients. 61
32829980 2020
47
Can food processing produce hypoallergenic egg? 61
32776546 2020
48
Adverse events in patients with hen's-egg-allergy who passed scrambled egg challenge. 61
32311153 2020
49
Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices - United States, 2020-21 Influenza Season. 61
32820746 2020
50
Diagnostic performance of IgE avidity for hen's egg allergy in young infants. 61
32268215 2020
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Variations for Egg Allergy

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Expression for Egg Allergy

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Search GEO for disease gene expression data for Egg Allergy.
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Pathways for Egg Allergy

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Pathways related to Egg Allergy according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Allograft rejection 36 1
Show member pathways
 12.68 IL5 IL4 IL13 IL10 FOXP3
2
T cell receptor signaling pathway 36
Show member pathways
 12.44 IL5 IL4 IL10 CSNK2B
3
Th17 cell differentiation 36
Show member pathways
 12.43 IL5 IL4 IL13 IL10 FOXP3
4
Immune response Fc epsilon RI pathway 23
Show member pathways
 12.41 IL5 IL4 IL13 IGHE
5
NF-kappaB Signaling 4
12.38 IL4 IL10 FOXP3 ENPP3
6
JAK-STAT signaling pathway 36
Show member pathways
 12.25 TSLP IL5 IL4 IL13 IL10
7
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.09 IL5 IL4 IL13 IL10
8
Interleukin-4 and 13 signaling 65
11.84 IL4 IL13 IL10 IGHE
9
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.83 IL5 IL4 IL10
10
Glucocorticoid receptor regulatory network 1
11.65 IL5 IL4 IL13
11
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.6 IL5 IL4 FOXP3
12
IL4-mediated signaling events 1
11.53 IL5 IL4 IL10 IGHE
13
Lung fibrosis 1
11.5 IL5 IL4 IL13
14
Interleukin-10 signaling 65
11.38 IL4 IL13 IL10
15
IgA-Producing B Cells in the Intestine 64
11.37 IL5 IL4 IL10 FOXP3 CCR6
16
Development and heterogeneity of the ILC family 1
11.17 TSLP IL5 IL4 IL13
17
Cytokines and Inflammatory Response 1
11.09 IL5 IL4 IL13 IL10
18
Th2 Differentiation Pathway 64
11.02 IL5 IL4 IL13 IL10 FOXP3
19
Innate Lymphoid Cell Differentiation Pathways 64
11 TSLP IL5 IL4 IL13 IL10 CCR6
20
OX40 Pathway 63
10.97 IL5 IL4 IL13 IL10
21
IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
10.66 IL5 IL4 IL13
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GO Terms for Egg Allergy

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Cellular components related to Egg Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 TSLP PTGDS LALBA IL5 IL4 IL13
2 extracellular region GO:0005576 9.32 TSLP PTGDS LALBA IL5 IL4 IL13

Biological processes related to Egg Allergy according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.13 TSLP PDCL LALBA IL5 IL4 IL10
2 negative regulation of tumor necrosis factor production GO:0032720 9.71 IL4 IL10 FOXP3
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.69 TSLP IL4 IL13
4 positive regulation of B cell proliferation GO:0030890 9.65 IL5 IL4 IL13
5 cytokine-mediated signaling pathway GO:0019221 9.65 IL5 IL4 IL13 IL10 IGHE
6 positive regulation of interleukin-10 production GO:0032733 9.63 TSLP IL4 IL13
7 immune response GO:0006955 9.63 IL5 IL4 IL13 IL10 IGHE CCR6
8 positive regulation of macrophage activation GO:0043032 9.59 IL13 IL10
9 macrophage activation GO:0042116 9.58 IL4 IL13
10 positive regulation of MHC class II biosynthetic process GO:0045348 9.58 IL4 IL10
11 positive regulation of interleukin-13 production GO:0032736 9.57 TSLP IL4
12 negative regulation of T-helper 17 cell differentiation GO:2000320 9.56 IL4 FOXP3
13 positive regulation of mast cell degranulation GO:0043306 9.55 IL4 IL13
14 negative regulation of endothelial cell apoptotic process GO:2000352 9.5 IL4 IL13 IL10
15 type 2 immune response GO:0042092 9.49 IL4 IL10
16 negative regulation of complement-dependent cytotoxicity GO:1903660 9.43 IL4 IL13
17 regulation of isotype switching GO:0045191 9.4 IL4 IL10
18 negative regulation of chronic inflammatory response GO:0002677 9.37 IL4 FOXP3
19 positive regulation of immunoglobulin production GO:0002639 9.13 IL5 IL13 IL10
20 negative regulation of inflammatory response GO:0050728 9.02 IL4 IL13 IL10 FOXP3 ENPP3

Molecular functions related to Egg Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TSLP IL5 IL4 IL13 IL10
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Sources for Egg Allergy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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