Aliases & Classifications for Egg Allergy

MalaCards integrated aliases for Egg Allergy:

Name: Egg Allergy 12 15 17
Egg Hypersensitivity 45
Allergy to Eggs 12
Allergies Egg 56

Classifications:



External Ids:

Disease Ontology 12 DOID:4377
MeSH 45 D021181
SNOMED-CT 69 91930004
UMLS 74 C0559469

Summaries for Egg Allergy

Disease Ontology : 12 A food allergy that is an allergy or hypersensitivity to dietary substances from the yolk or whites of eggs, causing an overreaction of the immune system which may lead to severe physical symptoms.

MalaCards based summary : Egg Allergy, also known as egg hypersensitivity, is related to dermatitis and dermatitis, atopic. An important gene associated with Egg Allergy is IL4 (Interleukin 4), and among its related pathways/superpathways are Immune response Fc epsilon RI pathway and Glucocorticoid receptor regulatory network. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and t cells.

Wikipedia : 77 Egg allergy is an immune hypersensitivity to proteins found in chicken eggs, and possibly goose, duck,... more...

Related Diseases for Egg Allergy

Diseases related to Egg Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 dermatitis 30.3 IGHE IL4 IL5
2 dermatitis, atopic 30.3 IGHE IL4 IL5
3 yellow fever 30.3 IL4 IL5
4 milk allergy 30.1 IL4 IL5
5 food allergy 30.0 IL4 IL5
6 respiratory allergy 29.7 IGHE IL4 IL5
7 allergic hypersensitivity disease 29.7 IGHE IL4 IL5
8 gastroenteritis 29.7 IL4 IL5
9 nut allergy 29.6 IL5 IQCE
10 chicken egg allergy 12.5
11 influenza 10.6
12 otitis media 10.2 IGHE IL4
13 immunodeficiency with hyper-igm, type 1 10.2 IGHE IL4
14 hyper ige syndrome 10.2 IGHE IL4
15 vernal conjunctivitis 10.2 IGHE IL4
16 keratoconjunctivitis 10.2 IL4 IL5
17 conjunctivitis 10.2 IL4 IL5
18 measles 10.2
19 nickel allergic contact dermatitis 10.1 IL4 IL5
20 allergic contact dermatitis 10.1 IL4 IL5
21 contact dermatitis 10.1 IL4 IL5
22 cough variant asthma 10.1 IL4 IL5
23 scleritis 10.1 IL4 IL5
24 inflammatory bowel disease 4 10.1 IL4 IL5
25 sulfamethoxazole allergy 10.1 IL4 IL5
26 angiostrongyliasis 10.1 IL4 IL5
27 intrinsic asthma 10.1 IL4 IL5
28 trichinosis 10.1 IL4 IL5
29 apple allergy 10.1 IL4 IL5
30 gaucher disease, type ii 10.1 IL4 IL5
31 non-suppurative otitis media 10.1 IL4 IL5
32 eosinophilic meningitis 10.1 IL4 IL5
33 intestinal schistosomiasis 10.1 IL4 IL5
34 chronic tic disorder 10.1 IL4 IL5
35 filarial elephantiasis 10.1 IL4 IL5
36 chronic conjunctivitis 10.1 IL4 IL5
37 eosinophilic gastritis 10.1 IL4 IL5
38 kimura disease 10.1 IL4 IL5
39 vernal keratoconjunctivitis 10.1 IL4 IL5
40 urinary schistosomiasis 10.1 IL4 IL5
41 folliculitis 10.1 IL4 IL5
42 enterobiasis 10.1 IL4 IL5
43 conjunctival disease 10.1 IL4 IL5
44 asthma 10.1
45 allergic bronchopulmonary aspergillosis 10.1 IL4 IL5
46 aspergillosis 10.1 IL4 IL5
47 pulmonary eosinophilia 10.1 IL4 IL5
48 paranasal sinus disease 10.1 IL4 IL5
49 onchocerciasis 10.1 IL4 IL5
50 allergic conjunctivitis 10.1 IL4 IL5

Graphical network of the top 20 diseases related to Egg Allergy:



Diseases related to Egg Allergy

Symptoms & Phenotypes for Egg Allergy

Drugs & Therapeutics for Egg Allergy

Drugs for Egg Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 1,Phase 2,Not Applicable
2 Immunologic Factors Phase 4,Phase 1,Phase 2,Not Applicable
3 Sennoside A&B Phase 2
4 Senna Phase 2
5
Nitric Oxide Approved Phase 1 10102-43-9 145068
6
Ipilimumab Approved Phase 1 477202-00-9
7
Metronidazole Approved Phase 1 443-48-1 4173
8
Sargramostim Approved, Investigational Phase 1 123774-72-1, 83869-56-1
9 Immunoglobulins Phase 1
10 Antibodies Phase 1
11 Endothelium-Dependent Relaxing Factors Phase 1
12 Bronchodilator Agents Phase 1
13 Respiratory System Agents Phase 1
14 Phosphodiesterase Inhibitors Phase 1
15 Protective Agents Phase 1
16 Antioxidants Phase 1
17 Vasodilator Agents Phase 1
18 Peripheral Nervous System Agents Phase 1
19 Free Radical Scavengers Phase 1
20 Anti-Asthmatic Agents Phase 1
21 Autonomic Agents Phase 1
22 Neurotransmitter Agents Phase 1
23 Anti-Infective Agents Phase 1
24 Antibodies, Monoclonal Phase 1
25 Anti-Bacterial Agents Phase 1
26 Androgens Phase 1
27 Antiprotozoal Agents Phase 1
28 Antiparasitic Agents Phase 1
29 Immunoglobulin E
30 Pharmaceutical Solutions Not Applicable
31 Hemagglutinins Not Applicable

Interventional clinical trials:

(show all 34)
# Name Status NCT ID Phase Drugs
1 Safety of Nasal Influenza Immunisation in Egg Allergic Children - The SNIFFLE 2 Study Completed NCT02111512 Phase 4 Administration of Live attenuated influenza vaccine (LAIV)
2 Basophil Activation Test (BAT) Sensitivity in Child Food Allergy Recruiting NCT01966640 Phase 4
3 Time-limited Specific Oral Tolerance Induction in Children With Severe Egg Allergy Completed NCT01379651 Phase 1, Phase 2
4 FluMist in Egg Allergic Patients Completed NCT01248208 Phase 1, Phase 2
5 Oral Immunotherapy for Childhood Egg Allergy Completed NCT00461097 Phase 2 Egg oral immunotherapy;Control Group
6 Baked Egg or Egg Oral Immunotherapy for Children With Egg Allergy Completed NCT01846208 Phase 2 Egg Oral Immunotherapy;Baked Egg
7 Promoting Tolerance to Peanut in High-Risk Children Completed NCT00329784 Phase 2
8 Persistence of Oral Tolerance to Peanut Completed NCT01366846 Phase 2
9 Short-term Behavioral Effects of Cholesterol Therapy in Smith-Lemli-Opitz Syndrome Completed NCT00114634 Phase 2
10 Accelerated Immunization to Induce Cytomegalovirus Immunity in Stem Cell Donors Completed NCT00353977 Phase 2
11 PSA-Based Vaccine and Radiotherapy to Treat Localized Prostate Cancer Completed NCT00005916 Phase 2 rV-PSA;rF-PSA;rV-B7.1
12 Oral AGY for Celiac Disease Completed NCT01765647 Phase 1
13 Cardiopulmonary Function Assessment and NO-Based Therapies for Patients With Hemolysis-Associated Pulmonary Hypertension Completed NCT00352430 Phase 1 Nitric Oxide/INP Pulse Delivery;Nitric Oxide/INO Pulse Delivery
14 Vaccine and Antibody Treatment of Prostate Cancer Completed NCT00113984 Phase 1 MDX-010;Sargramostim
15 Cow's Milk and Hen's Egg Hyposensitization in Adults Unknown status NCT02083471 Not Applicable
16 Treatment of Egg Allergy in Children Through Oral Desensitization (EGG OIT) Completed NCT00597558 Not Applicable Egg white protein
17 Clinical Tolerance to a Live Attenuated Vaccine Against Influenza (Flumist®) in a Population Allergic to Eggs Completed NCT02142491
18 Safe Administration of Flu Vaccine to Egg Allergic Children Completed NCT01264601 Not Applicable
19 Egg Oral Immunotherapy Completed NCT01489553
20 Safety of Nasal Influenza Immunisation in Egg Allergic Children Completed NCT01859039
21 Hydrolyzed Egg and Tolerance Induction Completed NCT01526863 Not Applicable
22 An Observational Study of Childhood Food Allergy Completed NCT00356174
23 Immunologic Profile of Children With Severe Allergies to Peanuts and Nuts After Induction of Tolerance Completed NCT01996774
24 Intranasal Diagnostics in Food Allergy: a Feasibility Study Completed NCT02159833 Not Applicable
25 Research in Skin Inflammation Completed NCT00026741
26 Impact of Vaccination on Th2 Immunity in Infancy Completed NCT02213341
27 Potential Allergens in Wine: Double-blind Placebo-controlled Trial Completed NCT00163735 Not Applicable Administration of wine fined with potential food allergens
28 The Effect of Per Oral Immunotherapy in Severe Milk, Peanut and Egg Allergy in Adults Recruiting NCT03361072 Not Applicable
29 Gradual Egg-tolerance Induction in Hen's Egg Allergic Children Recruiting NCT02487420 Not Applicable
30 Basophil Activation Test to Diagnose Food Allergy Recruiting NCT03309488
31 The Utility of Food-Specific IgE Measured With the IMMULITE 2000 Assay to Predict Symptomatic Food Allergy Active, not recruiting NCT01950533
32 The Effect of Per Oral Immunotherapy in Severe IgE Mediated Egg, Milk, and Nut Allergy in Adults Active, not recruiting NCT01822353 Not Applicable
33 Immune Responses in Hen's Egg Oral Immunotherapy Active, not recruiting NCT03744325 Not Applicable
34 Influenza Vaccine Post Allogeneic Transplant Terminated NCT01215981 Not Applicable

Search NIH Clinical Center for Egg Allergy

Cochrane evidence based reviews: egg hypersensitivity

Genetic Tests for Egg Allergy

Anatomical Context for Egg Allergy

MalaCards organs/tissues related to Egg Allergy:

42
Testes, Skin, T Cells, Prostate, Breast, B Cells

Publications for Egg Allergy

Articles related to Egg Allergy:

(show top 50) (show all 249)
# Title Authors Year
1
Oral Immunotherapy for Egg Allergy. ( 30702254 )
2019
2
Early Introduction of Egg and Development of Egg Allergy. ( 30739103 )
2019
3
Early Introduction of Egg and Development of Egg Allergy. ( 30739112 )
2019
4
Hyperresponsiveness to Boiled Egg Yolk in Early Life Leads to Prolonged Egg Allergy. ( 30912331 )
2019
5
Timing of regular egg intake for prevention of egg allergy. ( 29146009 )
2018
6
Egg-specific IgE and basophil activation but not egg-specific T-cell counts correlate with phenotypes of clinical egg allergy. ( 29518422 )
2018
7
A 10-year review found increasing incidence trends of emergency egg allergy reactions and food-induced anaphylaxis in children. ( 29920760 )
2018
8
The Oral Provocation Test for Raw Egg in Patients with Hen Egg Allergy. ( 29874663 )
2018
9
Debates in Allergy Medicine: Does oral immunotherapyA shorten the duration of milk and egg allergy?A The pro argument. ( 29977438 )
2018
10
Debates in Allergy Medicine: Oral immunotherapy shortens the duration of milk and egg allergy - the con argument. ( 29977439 )
2018
11
Early-life gut microbiome and egg allergy. ( 29318631 )
2018
12
Clinical and immunological profile of children aged 5-9 years with persistent egg allergy before oral immunotherapy with egg. A multicenter, randomized controlled trial of the Spanish Society of Pediatric Allergy, Asthma and Clinical Immunology (SEICAP). ( 29804794 )
2018
13
Oral and sublingual immunotherapy for egg allergy. ( 29676439 )
2018
14
The effect of oral immunotherapy treatment in severe IgE mediated milk, peanut, and egg allergy in adults. ( 29542268 )
2018
15
Development of Food Protein-Induced Enterocolitis Syndrome (FPIES) to egg following Immunoglobulin E (IgE)-mediated egg allergy<sup/>. ( 29859249 )
2018
16
Acquisition of tolerance to egg allergy in a child with repeated egg-induced acute pancreatitis. ( 29754972 )
2018
17
Are both early egg introduction and eczema treatment necessary for primary prevention of egg allergy? ( 29522845 )
2018
18
Search for a Novel Allergen in Hen's Egg Allergy Using an IgE Immunoblotting Assay. ( 29669337 )
2018
19
Egg allergen specific IgE diversity predicts resolution of egg allergy in the population cohort HealthNuts. ( 30035811 )
2018
20
Early Introduction of Egg and the Development of Egg Allergy in Children: A Systematic Review and Meta-Analysis. ( 30184525 )
2018
21
Apovitellin identified as a novel major egg allergen in goose egg allergy. ( 30346628 )
2018
22
The efficiency of the symptom-based score in infants diagnosed with cow's milk protein and hen's egg allergy. ( 30501905 )
2018
23
B-cell phenotype and function in infants with egg allergy. ( 30589939 )
2018
24
Oral immunotherapy in children with IgE-mediated hen's egg allergy: Follow-ups at 2.5 and 7 years. ( 29070273 )
2017
25
Egg allergy prevention. ( 29205663 )
2017
26
Association Between Family Characteristics and the Effect of Timing of Regular Egg Introduction in Infant Egg Allergy. ( 28346598 )
2017
27
Component-resolved diagnostics in Thai children with cow's milk and egg allergy. ( 28364406 )
2017
28
Eosinophilic Esophagitis After Egg Oral Immunotherapy in an Adult With Egg-Allergy and Egg-Bird Syndrome. ( 28731415 )
2017
29
Hydrolysed ovalbumin offers more effective preventive and therapeutic protection against egg allergy than the intact protein. ( 28763132 )
2017
30
Update on oral immunotherapy for egg allergy. ( 28696863 )
2017
31
A successful case of egg allergy tolerance achieved at a local clinic. ( 28216056 )
2017
32
Food Protein-Induced Enterocolitis Syndrome in Response to Quail's Egg in a Child Without Hen's Egg Allergy. ( 29199963 )
2017
33
How to prevent egg allergy. ( 28232461 )
2017
34
The Pathogenesis of Rheumatoid Arthritis is Associated with Milk or Egg Allergy. ( 27011946 )
2016
35
Debates in allergy medicine: baked milk and egg ingestion accelerates resolution of milk and egg allergy. ( 26839628 )
2016
36
Relationship between specific IgE to egg components and natural history of egg allergy in Danish children. ( 27565949 )
2016
37
Safety and Efficacy of Low-Dose Oral Immunotherapy for Hen's Egg Allergy in Children. ( 28049193 )
2016
38
Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomised, double-blind, placebo-controlled trial. ( 27939035 )
2016
39
Influenza vaccination and egg allergy: another step forward. ( 27012268 )
2016
40
Randomized controlled trial of early regular egg intake to prevent egg allergy. ( 27554812 )
2016
41
A randomized trial of egg introduction from 4A months of age in infants at risk for egg allergy. ( 27742394 )
2016
42
Transcriptional Profiling of Egg Allergy and Relationship to Disease Phenotype. ( 27788149 )
2016
43
Randomized Controlled Trial of Oral Immunotherapy for Egg Allergy in Japanese patients. ( 27914210 )
2016
44
Predictive values of egg specific IgE by two commonly used assay systems for the diagnosis of egg allergy in young children: a prospective multicenter study. ( 27061295 )
2016
45
Comparison of ImmunoCAP and Immulite serum specific IgE assays for the assessment of egg allergy. ( 27293451 )
2016
46
Matrix effect on baked egg tolerance in children with IgE-mediated hen's egg allergy. ( 27019388 )
2016
47
Consultation with registered dietitian to prevent accidental reactions to food: insight from an egg allergy influenza vaccination cohort. ( 28000691 )
2016
48
Protein-losing enteropathy and erythema caused by egg allergy in a breast-fed infant. ( 26818703 )
2016
49
Natural history of immediate-type hen's egg allergy in Japanese children. ( 26666473 )
2016
50
Heated egg yolk challenge predicts the natural course of hen's egg allergy: a retrospective study. ( 27777641 )
2016

Variations for Egg Allergy

Expression for Egg Allergy

Search GEO for disease gene expression data for Egg Allergy.

Pathways for Egg Allergy

GO Terms for Egg Allergy

Cellular components related to Egg Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CSNK2B IGHE IL4 IL5 PTGDS
2 cilium GO:0005929 8.8 ARL2BP CSNK2B IQCE

Biological processes related to Egg Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.33 IGHE IL4 IL5
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.26 ARL2BP IL4
3 positive regulation of B cell proliferation GO:0030890 8.96 IL4 IL5
4 immune response GO:0006955 8.92 CCR6 IGHE IL4 IL5

Sources for Egg Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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