Aliases & Classifications for Egg Allergy

MalaCards integrated aliases for Egg Allergy:

Name: Egg Allergy 12 15 17
Egg Hypersensitivity 44
Allergy to Eggs 12
Allergies Egg 54


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Disease Ontology 12 DOID:4377
MeSH 44 D021181
SNOMED-CT 67 91930004
UMLS 71 C0559469

Summaries for Egg Allergy

Disease Ontology : 12 A food allergy that is an allergy or hypersensitivity to dietary substances from the yolk or whites of eggs, causing an overreaction of the immune system which may lead to severe physical symptoms.

MalaCards based summary : Egg Allergy, also known as egg hypersensitivity, is related to rubella and cytokine deficiency. An important gene associated with Egg Allergy is IGHE (Immunoglobulin Heavy Constant Epsilon), and among its related pathways/superpathways are Allograft rejection and T cell receptor signaling pathway. The drugs Vaccines and Immunoglobulin E have been mentioned in the context of this disorder. Affiliated tissues include skin, thymus and t cells, and related phenotypes are hematopoietic system and digestive/alimentary

Wikipedia : 74 Egg allergy is an immune hypersensitivity to proteins found in chicken eggs, and possibly goose, duck,... more...

Related Diseases for Egg Allergy

Diseases related to Egg Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 300)
# Related Disease Score Top Affiliating Genes
1 rubella 30.6 IL5 IL4 IL10
2 cytokine deficiency 30.2 IL5 IL13
3 ige responsiveness, atopic 30.1 IL5 IL4 IL13 IL10 IGHE
4 urticaria 30.1 IL5 IL4 IL13 IGHE ENPP3
5 diphtheria 29.9 IL5 IL4 IL13
6 food allergy 29.9 IL5 IL4 IL13 IL10 IGHE FOXP3
7 tetanus 29.8 IL5 IL4 IL13 IL10
8 cholera 29.8 IL5 IL4 IL10
9 chronic urticaria 29.7 IL4 IL13 IGHE ENPP3
10 cow milk allergy 29.7 LALBA IL5 IL4 IL10
11 hypereosinophilic syndrome 29.7 IL5 IL4 IL13 IL10 IGHE
12 milk allergy 29.6 LALBA IL5 IL4 IL13 IL10 IGHE
13 allergic rhinitis 29.6 IL5 IL4 IL13 IL10 IGHE
14 gastroenteritis 29.5 TSLP IL5 IL4 IL10
15 eosinophilic gastroenteritis 29.5 TSLP IL5 IL4 CCR6
16 allergic disease 29.5 TSLP IL5 IL4 IL13 FOXP3 CCR6
17 peanut allergy 29.4 PEDS1 IL5 IL4 IL13 IL10 IGHE
18 allergic conjunctivitis 29.2 IL5 IL4 IL13 IL10 IGHE FOXP3
19 arthritis 29.2 IL4 IL13 IL10 FOXP3 CCR6
20 conjunctivitis 29.1 IL5 IL4 IL13 IL10 IGHE FOXP3
21 autoimmune disease 29.0 IL5 IL4 IL13 IL10 FOXP3 CCR6
22 esophagitis, eosinophilic, 1 28.9 TSLP IL5 IL4 IL13 FLG CCR6
23 rheumatoid arthritis 28.9 IL4 IL13 IL10 FOXP3 FLG CCR6
24 rhinitis 28.9 TSLP IL5 IL4 IL13 IL10 IGHE
25 dermatitis 28.8 TSLP IL5 IL4 IL13 IL10 IGHE
26 dermatitis, atopic 28.7 TSLP LALBA IL5 IL4 IL13 IL10
27 esophagitis 28.7 TSLP IL5 IL4 IL13 IL10 FLG
28 nut allergy 28.6 PDCL IL5 IL4 IL13 IGHE FLG
29 asthma 28.3 TSLP IL5 IL4 IL13 IL10 IGHE
30 respiratory allergy 28.0 PDCL IL5 IL4 IL13 IL10 IGHE
31 chicken egg allergy 11.6
32 influenza 10.5
33 measles 10.4
34 mumps 10.4
35 acute asthma 10.3 IL5 IL4
36 amoxicillin allergy 10.3 IGHE ENPP3
37 childhood-onset asthma 10.3 IL13 IGHE
38 aztreonam allergy 10.3 IL5 IL13
39 crab allergy 10.3 IL5 ENPP3
40 cefaclor allergy 10.3 IL5 IL13
41 atopic keratoconjunctivitis 10.3 IL5 IL4 IGHE
42 toxic oil syndrome 10.3 IL5 IL4 IGHE
43 cefuroxime allergy 10.3 IL5 IL13
44 cough variant asthma 10.3 IL5 IL4 IGHE
45 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL5 IL13
46 yellow fever 10.3
47 vernal conjunctivitis 10.3 IL4 IGHE CCR6
48 respiratory syncytial virus infectious disease 10.3 IL5 IL13
49 pustulosis palmaris et plantaris 10.2 IL5 CCR6
50 immunodeficiency with hyper-igm, type 1 10.2 IL4 IGHE CCR6

Graphical network of the top 20 diseases related to Egg Allergy:

Diseases related to Egg Allergy

Symptoms & Phenotypes for Egg Allergy

MGI Mouse Phenotypes related to Egg Allergy:

# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 CCR6 COPS7A ENPP3 FOXP3 IL10 IL13
2 digestive/alimentary MP:0005381 9.8 ENPP3 FOXP3 IL10 IL13 IL4 IL5
3 immune system MP:0005387 9.65 CCR6 COPS7A ENPP3 FOXP3 IL10 IL13
4 respiratory system MP:0005388 9.17 ENPP3 FOXP3 IL10 IL13 IL4 IL5

Drugs & Therapeutics for Egg Allergy

Drugs for Egg Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4
2 Immunoglobulin E
3 Immunoglobulins
4 Immunoglobulins, Intravenous
5 Antibodies

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Phase 4 Study to Assess the Safety of Nasal Influenza Immunisation in Egg Allergic Children - a Multicentre Observational Study Completed NCT02111512 Phase 4 Administration of Live attenuated influenza vaccine (LAIV)
2 Basophil Activation Test (BAT) Sensitivity in Child Food Allergy Completed NCT01966640 Phase 4
3 Flu Vaccine in Egg-allergic Patients Minimizing Injections Safety Trial Completed NCT01248208 Phase 1, Phase 2
4 Induction of Tolerance Through Early Introduction of Peanut in High-Risk Children (ITN032AD) Completed NCT00329784 Phase 2
5 Specific Oral Tolerance Induction in Children With Severe Egg Allergy: A Randomized Controlled Trial Using a 6 Months Protocol Completed NCT01379651 Phase 1, Phase 2
6 The Persistence of Oral Tolerance Induction to Peanut and Its Immunological Basis (ITN049AD) Completed NCT01366846 Phase 2
7 Phase 2 Study of AR201 Oral Immunotherapy for Desensitization in Children, Adolescents, and Young Adults With Hen Egg Allergy Active, not recruiting NCT04056299 Phase 2
8 Cow's Milk and Hen's Egg Hyposensitization in Adults Unknown status NCT02083471
9 Egg Oral Immunotherapy Completed NCT01489553
10 Potential Allergens in Wine: Double Blind Placebo-controlled Trial and Basophil Activation Analysis Completed NCT00163735 Administration of wine fined with potential food allergens
11 The Effect of Per Oral Immunotherapy in Severe IgE Mediated Egg, Milk and Nut Allergy in Adults Completed NCT01822353
12 Multi-Centered, Randomized, Placebo-Controlled Trial of the Safety of Influenza Vaccine in Egg Allergic Children With a History of Anaphylaxis or Severe Allergy to Egg Completed NCT01264601
13 Pilot Project on Clinical Tolerance to a Live Attenuated Vaccine Against Influenza (Flumist®) in the Context of Influenza Vaccination in a Population Allergic to Eggs. Completed NCT02142491
14 Treatment of Egg Allergy in Children Through Oral Desensitization (EGG OIT) Completed NCT00597558 Egg white protein
15 The Utility of Food-Specific IgE Measured With the IMMULITE 2000 Assay to Predict Symptomatic Food Allergy Completed NCT01950533
16 Phase 4 Study to Assess the Safety of Nasal Influenza Immunisation in Egg Allergic Children - a Multicentre Observational Study Completed NCT01859039
17 A Prospective Cohort Study of Immune Mechanisms, Genetic Factors, and Clinical and Environmental Characteristics Associated With the Occurrence and Clinical Outcome of Food Allergy (CoFAR2) Completed NCT00356174
18 The Effect of Per Oral Immunotherapy Treatment in Severe IgE Mediated Milk, Peanut and Egg Allergy in Adults Recruiting NCT03361072
19 Gradual Egg-tolerance Induction in Hen's Egg Allergic Children Who Tolerate Baked Egg (TETI-II Study) Recruiting NCT04677790
20 Basophil Activation Test to Diagnose Food Allergy Recruiting NCT03309488
21 Trapsgewijze Ei-tolerantie-inductie Bij Kippenei-allergische Kinderen (TETI Studie) Active, not recruiting NCT02487420

Search NIH Clinical Center for Egg Allergy

Cochrane evidence based reviews: egg hypersensitivity

Genetic Tests for Egg Allergy

Anatomical Context for Egg Allergy

MalaCards organs/tissues related to Egg Allergy:

Skin, Thymus, T Cells

Publications for Egg Allergy

Articles related to Egg Allergy:

(show top 50) (show all 678)
# Title Authors PMID Year
Lipocalin-type prostaglandin D synthase and egg white cystatin react with IgE antibodies from children with egg allergy. 54 61
20179418 2010
Correlation between specific immunoglobulin E levels and the severity of reactions in egg allergic patients. 54 61
18257905 2008
The natural history of egg allergy. 61 54
18073126 2007
Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy. 54 61
17573723 2007
Detection of four distinct groups of hen egg allergens binding IgE in the sera of children with egg allergy. 61 54
16045855 2005
Determination of food specific IgE levels over time can predict the development of tolerance in cow's milk and hen's egg allergy. 54 61
15316521 2004
Possible modes of allergen-specific sensitization and boosting in an atopic child. 61 54
12740528 2003
Prediction of tolerance on the basis of quantification of egg white-specific IgE antibodies in children with egg allergy. 61 54
12170273 2002
Cellular immune responses to ovalbumin and house dust mite in egg-allergic children. 54 61
11906334 2002
Cytokine production in children outgrowing hen egg allergy. 54 61
8955579 1996
Establishment and characterization of ovalbumin-specific T cell lines from patients with egg allergy. 54 61
8634518 1996
Allergenic epitopes of ovalbumin (OVA) in patients with hen's egg allergy: inhibition of basophil histamine release by haptenic ovalbumin peptide. 54 61
8608645 1996
[IgE production and gene expression of interleukin-4 and interferon-gamma by peripheral mononuclear cells in asthmatic children]. 61 54
7726752 1995
Identification of the disease-related T cell epitope of ovalbumin and epitope-targeted T cell inactivation in egg allergy. 61 54
7522686 1994
Egg white-specific IgE level as a tolerance marker in the follow up of egg allergy. 54 61
8034192 1994
[The production of B cell stimulating activity in peripheral blood mononuclear cells from allergic children with positive IgE RAST score to egg white]. 54 61
2053859 1991
[Primary prevention of food allergy in childhood]. 61
33570030 2021
Infant Allergy Testing and Food Allergy Diagnoses Before and After Guidelines for Early Peanut Introduction. 61
33186769 2021
A Randomized, Open-Label Trial of Hen's Egg Oral Immunotherapy: Efficacy and Humoral Immune Responses in 50 Children. 61
33529723 2021
Home-based, slow up-dosing oral immunotherapy for hen's egg allergy in an adult patient. 61
33604272 2021
Successful sublingual immunotherapy for severe egg allergy in children: a case report. 61
33407837 2021
A Mouse Model of Oral Sensitization to Hen's Egg White. 61
33226586 2021
Efficacy, safety, and parental anxiety in a randomized trial of two dietary instruction methods for children with suspected hen's egg allergy. 61
32814667 2021
Risk factors of food sensitization in young children with atopic dermatitis. 61
33386793 2021
A Consensus Approach to the Primary Prevention of Food Allergy Through Nutrition: Guidance from the American Academy of Allergy, Asthma, and Immunology; American College of Allergy, Asthma, and Immunology; and the Canadian Society for Allergy and Clinical Immunology. 61
33250376 2021
Specific IgE levels as an outcome predictor in egg-allergic children. 61
33528933 2021
Agreement Between Predictive, Allergen-Specific IgE Values Assessed by ImmunoCAP and IMMULITE 2000 3gAllergy™ Assay Systems for Milk and Wheat Allergies. 61
33191682 2021
Detection of specific IgE against linear epitopes from Gal d 1 has additional value in diagnosing hen's egg allergy in adults. 61
32909666 2020
Behavior Change, Egg Consumption, and Child Nutrition: A Cluster Randomized Controlled Trial. 61
33239474 2020
Evaluation of baked egg oral immunotherapy in French children with hen's egg allergy. 61
33349960 2020
Investigation of Basophil Activation Test for Diagnosing Milk and Egg Allergy in Younger Children. 61
33291359 2020
Epidemiological study of food allergy in a population of Argentine children. 61
33231050 2020
An update on international practice variation in peanut introduction: conundrums, controversies, and a new direction. 61
33060444 2020
Allergy and immunology in young children of Japan: The JECS cohort. 61
33204389 2020
Safety of measles, mumps, and rubella vaccine in egg allergy: in vivo and in vitro management. 61
33292334 2020
A virtual management approach to infant egg allergy developed in response to pandemic-imposed restrictions. 61
33244828 2020
Baked egg tolerance: is it possible to predict? 61
31513760 2020
Utility of fresh egg skin prick test and egg yolk specific immunoglobulin E for outgrowth. 61
32526376 2020
Induction of sustained unresponsiveness after egg oral immunotherapy compared to baked egg therapy in children with egg allergy. 61
32535135 2020
Ovomucoid epitope-specific repertoire of IgE, IgG4 , IgG1 , IgA1 , and IgD antibodies in egg-allergic children. 61
32391917 2020
Egg yolk augments type 2 immunity by activating innate cells. 61
31903504 2020
Longitudinal egg-specific regulatory T- and B-cell development: Insights from primary prevention clinical trials examining the timing of egg introduction. 61
33040362 2020
Pediatric Allergic Diseases, Food Allergy, and Oral Tolerance. 61
32634325 2020
Preventing food allergy in infancy and childhood: Systematic review of randomised controlled trials. 61
32396244 2020
Egg Allergy in US Children. 61
32376485 2020
Safety of yellow fever vaccine administration in confirmed egg-allergic patients. 61
32829980 2020
Can food processing produce hypoallergenic egg? 61
32776546 2020
Adverse events in patients with hen's-egg-allergy who passed scrambled egg challenge. 61
32311153 2020
Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices - United States, 2020-21 Influenza Season. 61
32820746 2020
Diagnostic performance of IgE avidity for hen's egg allergy in young infants. 61
32268215 2020

Variations for Egg Allergy

Expression for Egg Allergy

Search GEO for disease gene expression data for Egg Allergy.

Pathways for Egg Allergy

Pathways related to Egg Allergy according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
Show member pathways
12.68 IL5 IL4 IL13 IL10 FOXP3
Show member pathways
12.44 IL5 IL4 IL10 CSNK2B
Show member pathways
12.43 IL5 IL4 IL13 IL10 FOXP3
Show member pathways
12.41 IL5 IL4 IL13 IGHE
5 12.38 IL4 IL10 FOXP3 ENPP3
Show member pathways
12.25 TSLP IL5 IL4 IL13 IL10
Show member pathways
12.09 IL5 IL4 IL13 IL10
8 11.84 IL4 IL13 IL10 IGHE
9 11.83 IL5 IL4 IL10
10 11.65 IL5 IL4 IL13
Show member pathways
11.6 IL5 IL4 FOXP3
12 11.53 IL5 IL4 IL10 IGHE
13 11.5 IL5 IL4 IL13
14 11.38 IL4 IL13 IL10
15 11.37 IL5 IL4 IL10 FOXP3 CCR6
16 11.17 TSLP IL5 IL4 IL13
17 11.09 IL5 IL4 IL13 IL10
18 11.02 IL5 IL4 IL13 IL10 FOXP3
19 11 TSLP IL5 IL4 IL13 IL10 CCR6
20 10.97 IL5 IL4 IL13 IL10
21 10.66 IL5 IL4 IL13

GO Terms for Egg Allergy

Cellular components related to Egg Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 TSLP PTGDS LALBA IL5 IL4 IL13
2 extracellular region GO:0005576 9.32 TSLP PTGDS LALBA IL5 IL4 IL13

Biological processes related to Egg Allergy according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.13 TSLP PDCL LALBA IL5 IL4 IL10
2 negative regulation of tumor necrosis factor production GO:0032720 9.71 IL4 IL10 FOXP3
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.69 TSLP IL4 IL13
4 positive regulation of B cell proliferation GO:0030890 9.65 IL5 IL4 IL13
5 cytokine-mediated signaling pathway GO:0019221 9.65 IL5 IL4 IL13 IL10 IGHE
6 positive regulation of interleukin-10 production GO:0032733 9.63 TSLP IL4 IL13
7 immune response GO:0006955 9.63 IL5 IL4 IL13 IL10 IGHE CCR6
8 positive regulation of macrophage activation GO:0043032 9.59 IL13 IL10
9 macrophage activation GO:0042116 9.58 IL4 IL13
10 positive regulation of MHC class II biosynthetic process GO:0045348 9.58 IL4 IL10
11 positive regulation of interleukin-13 production GO:0032736 9.57 TSLP IL4
12 negative regulation of T-helper 17 cell differentiation GO:2000320 9.56 IL4 FOXP3
13 positive regulation of mast cell degranulation GO:0043306 9.55 IL4 IL13
14 negative regulation of endothelial cell apoptotic process GO:2000352 9.5 IL4 IL13 IL10
15 type 2 immune response GO:0042092 9.49 IL4 IL10
16 negative regulation of complement-dependent cytotoxicity GO:1903660 9.43 IL4 IL13
17 regulation of isotype switching GO:0045191 9.4 IL4 IL10
18 negative regulation of chronic inflammatory response GO:0002677 9.37 IL4 FOXP3
19 positive regulation of immunoglobulin production GO:0002639 9.13 IL5 IL13 IL10
20 negative regulation of inflammatory response GO:0050728 9.02 IL4 IL13 IL10 FOXP3 ENPP3

Molecular functions related to Egg Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TSLP IL5 IL4 IL13 IL10

Sources for Egg Allergy

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
70 Tocris
72 UMLS via Orphanet
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