MCID: EGG001
MIFTS: 42

Egg Allergy

Categories: Immune diseases
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Aliases & Classifications for Egg Allergy

MalaCards integrated aliases for Egg Allergy:

Name: Egg Allergy 11 14 16 75
Egg Hypersensitivity 43
Allergy to Eggs 11
Allergies Egg 53

Classifications:



External Ids:

Disease Ontology 11 DOID:4377
MeSH 43 D021181
NCIt 49 C172313
SNOMED-CT 68 91930004
UMLS 71 C0559469

Summaries for Egg Allergy

Disease Ontology: 11 A food allergy that is an allergy or hypersensitivity to dietary substances from the yolk or whites of eggs, causing an overreaction of the immune system which may lead to severe physical symptoms.

MalaCards based summary: Egg Allergy, also known as egg hypersensitivity, is related to rubella and angioedema. An important gene associated with Egg Allergy is IGHE (Immunoglobulin Heavy Constant Epsilon), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. The drugs Vaccines and Propofol have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and breast, and related phenotypes are immune system and no phenotypic analysis

Wikipedia: 75 Egg allergy is an immune hypersensitivity to proteins found in chicken eggs, and possibly goose, duck,... more...

Related Diseases for Egg Allergy

Diseases related to Egg Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 445)
# Related Disease Score Top Affiliating Genes
1 rubella 30.7 IL5 IL4 IL10
2 angioedema 30.3 IL5 IL10 IGHE
3 ige responsiveness, atopic 30.2 IL5 IL4 IL13 IL10 IGHE
4 gastroenteritis 30.2 IL5 IL4 IL10
5 eosinophilic gastroenteritis 30.1 IL5 IL4 IL13 IGHE
6 chronic urticaria 30.0 IL5 IGHE ENPP3
7 tetanus 29.9 IL5 IL4 IL13 IL10
8 diphtheria 29.9 IL5 IL4 IL13
9 hypereosinophilic syndrome 29.8 IL5 IL4 IL13 IL10 IGHE
10 allergic rhinitis 29.7 IL5 IL4 IL13 IL10 IGHE
11 chronic rhinitis 29.5 PEDS1 PDCL IL5 IL4 IL13 GHITM
12 dermatitis 29.4 TSLP IL5 IL4 IL13 IL10 IGHE
13 conjunctivitis 29.3 IL5 IL4 IL13 IL10 IGHE FOXP3
14 esophagitis, eosinophilic, 1 29.2 TSLP IL5 IL4 IL13 FLG CCR6
15 autoimmune disease 29.2 IL5 IL4 IL13 IL10 FOXP3 CCR6
16 urticaria 29.2 TSLP IL5 IL4 IL13 IL10 IGHE
17 esophagitis 29.1 TSLP IL5 IL4 IL13 IL10 FLG
18 rhinitis 29.1 TSLP IL5 IL4 IL13 IL10 IGHE
19 allergic disease 28.7 TSLP LALBA IL5 IL4 IL13 IL10
20 cow milk allergy 28.7 PEDS1 LALBA IL5 IL4 IL13 IL10
21 nut allergy 28.5 PEDS1 PDCL IL5 IL4 IL13 IGHE
22 rheumatoid arthritis 28.5 IL4 IL13 IL10 FOXP3 FLG CD4
23 allergic conjunctivitis 28.5 TSLP IL5 IL4 IL13 IL10 IGHE
24 occupational asthma 28.5 TSLP PEDS1 IL5 IL4 IL13 GHITM
25 milk allergy 28.4 TSLP PEDS1 LALBA IL5 IL4 IL13
26 asthma 28.2 TSLP IL5 IL4 IL13 IL10 IGHE
27 food allergy 28.1 TSLP PEDS1 PDCL LALBA IL5 IL4
28 dermatitis, atopic 28.0 TSLP PEDS1 LALBA IL5 IL4 IL13
29 allergic contact dermatitis 28.0 TSLP IL5 IL4 IL13 IL10 FOXP3
30 contact dermatitis 27.8 TSLP PEDS1 IL5 IL4 IL13 IL10
31 peanut allergy 27.2 TSLP PEDS1 PDCL IL5 IL4 IL13
32 respiratory allergy 26.9 TSLP PEDS1 PDCL IL5 IL4 IL13
33 chicken egg allergy 11.6
34 measles 10.4
35 mumps 10.4
36 enterobiasis 10.3 IL5 IL4
37 yellow fever 10.3
38 cercarial dermatitis 10.3 IL5 IL4
39 crab allergy 10.3 PEDS1 ENPP3
40 apricot allergy 10.3 PEDS1 ENPP3
41 photoallergic dermatitis 10.3 FLG CCR6
42 aztreonam allergy 10.3 IL5 IL13
43 dermatographia 10.3 IGHE ENPP3
44 nickel allergic contact dermatitis 10.3 IL5 IL13
45 kimura disease 10.3 IL5 IL4 IGHE
46 cephalosporin allergy 10.3 PEDS1 ENPP3
47 cefaclor allergy 10.3 IL5 IL13
48 respiratory syncytial virus infectious disease 10.2 IL5 IL13
49 oxirane allergy 10.2 PEDS1 ENPP3
50 vernal keratoconjunctivitis 10.2 IL4 IL13

Graphical network of the top 20 diseases related to Egg Allergy:



Diseases related to Egg Allergy

Symptoms & Phenotypes for Egg Allergy

MGI Mouse Phenotypes related to Egg Allergy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.9 CCR6 CD4 ENPP3 FOXP3 IGHE IL10
2 no phenotypic analysis MP:0003012 9.87 CD4 FOXP3 IGHE IL10 IL13 IL4
3 digestive/alimentary MP:0005381 9.86 CD4 ENPP3 FOXP3 IL10 IL13 IL4
4 respiratory system MP:0005388 9.5 ENPP3 FOXP3 IL10 IL13 IL4 IL5
5 hematopoietic system MP:0005397 9.4 CCR6 CD4 ENPP3 FOXP3 IGHE IL10

Drugs & Therapeutics for Egg Allergy

Drugs for Egg Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4
2
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
3 Immunoglobulins, Intravenous
4 Immunoglobulin E
5 Anesthetics, Intravenous
6 Soy Bean
7 Anesthetics, General
8 Anesthetics
9 Hypnotics and Sedatives
10 Immunoglobulins
11 Antibodies

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Phase 4 Study to Assess the Safety of Nasal Influenza Immunisation in Egg Allergic Children - a Multicentre Observational Study Completed NCT02111512 Phase 4 Administration of Live attenuated influenza vaccine (LAIV)
2 Induction of Tolerance Through Early Introduction of Peanut in High-Risk Children (ITN032AD) Completed NCT00329784 Phase 2
3 Flu Vaccine in Egg-allergic Patients Minimizing Injections Safety Trial Completed NCT01248208 Phase 1, Phase 2
4 The Persistence of Oral Tolerance Induction to Peanut and Its Immunological Basis (ITN049AD) Completed NCT01366846 Phase 2
5 Specific Oral Tolerance Induction in Children With Severe Egg Allergy: A Randomized Controlled Trial Using a 6 Months Protocol Completed NCT01379651 Phase 1, Phase 2
6 Phase 2 Study of AR201 Oral Immunotherapy for Desensitization in Children, Adolescents, and Young Adults With Hen Egg Allergy Terminated NCT04056299 Phase 2
7 Cow's Milk and Hen's Egg Hyposensitization in Adults Unknown status NCT02083471
8 Basophil Activation Test to Diagnose Food Allergy Unknown status NCT03309488
9 The Utility of Food-Specific IgE Measured With the IMMULITE 2000 Assay to Predict Symptomatic Food Allergy Completed NCT01950533
10 Pilot Project on Clinical Tolerance to a Live Attenuated Vaccine Against Influenza (Flumist®) in the Context of Influenza Vaccination in a Population Allergic to Eggs. Completed NCT02142491
11 Multi-Centered, Randomized, Placebo-Controlled Trial of the Safety of Influenza Vaccine in Egg Allergic Children With a History of Anaphylaxis or Severe Allergy to Egg Completed NCT01264601
12 Treatment of Egg Allergy in Children Through Oral Desensitization (EGG OIT) Completed NCT00597558 Egg white protein
13 Phase 4 Study to Assess the Safety of Nasal Influenza Immunisation in Egg Allergic Children - a Multicentre Observational Study Completed NCT01859039
14 A Prospective Cohort Study of Immune Mechanisms, Genetic Factors, and Clinical and Environmental Characteristics Associated With the Occurrence and Clinical Outcome of Food Allergy (CoFAR2) Completed NCT00356174
15 Egg Oral Immunotherapy Completed NCT01489553
16 Incidence of Perioperative Hypersensitivity Reactions to Propofol in Children Allergic to Egg and/or Soy Completed NCT04839666 Propofol
17 Gradual Egg-tolerance Induction in Hen's Egg Allergic Children Who Tolerate Baked Egg (TETI-II Study) Recruiting NCT04677790
18 The Effect of Per Oral Immunotherapy Treatment in Severe IgE Mediated Milk, Peanut and Egg Allergy in Adults Active, not recruiting NCT03361072
19 Trapsgewijze Ei-tolerantie-inductie Bij Kippenei-allergische Kinderen (TETI Studie) Active, not recruiting NCT02487420
20 Randomised Controlled Multicentre Trial on the Clinical Impact of the Basophil Activation Test and the Mast Cell Activation Test as Food Allergy Biomarkers in Children and Young People Not yet recruiting NCT05309772

Search NIH Clinical Center for Egg Allergy

Cochrane evidence based reviews: egg hypersensitivity

Genetic Tests for Egg Allergy

Anatomical Context for Egg Allergy

Organs/tissues related to Egg Allergy:

MalaCards : Skin, T Cells, Breast, Thymus, Liver

Publications for Egg Allergy

Articles related to Egg Allergy:

(show top 50) (show all 754)
# Title Authors PMID Year
1
Lipocalin-type prostaglandin D synthase and egg white cystatin react with IgE antibodies from children with egg allergy. 53 62
20179418 2010
2
Correlation between specific immunoglobulin E levels and the severity of reactions in egg allergic patients. 53 62
18257905 2008
3
The natural history of egg allergy. 53 62
18073126 2007
4
Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy. 53 62
17573723 2007
5
Detection of four distinct groups of hen egg allergens binding IgE in the sera of children with egg allergy. 53 62
16045855 2005
6
Determination of food specific IgE levels over time can predict the development of tolerance in cow's milk and hen's egg allergy. 53 62
15316521 2004
7
Possible modes of allergen-specific sensitization and boosting in an atopic child. 53 62
12740528 2003
8
Prediction of tolerance on the basis of quantification of egg white-specific IgE antibodies in children with egg allergy. 53 62
12170273 2002
9
Cellular immune responses to ovalbumin and house dust mite in egg-allergic children. 53 62
11906334 2002
10
Cytokine production in children outgrowing hen egg allergy. 53 62
8955579 1996
11
Establishment and characterization of ovalbumin-specific T cell lines from patients with egg allergy. 53 62
8634518 1996
12
Allergenic epitopes of ovalbumin (OVA) in patients with hen's egg allergy: inhibition of basophil histamine release by haptenic ovalbumin peptide. 53 62
8608645 1996
13
[IgE production and gene expression of interleukin-4 and interferon-gamma by peripheral mononuclear cells in asthmatic children]. 53 62
7726752 1995
14
Identification of the disease-related T cell epitope of ovalbumin and epitope-targeted T cell inactivation in egg allergy. 53 62
7522686 1994
15
Egg white-specific IgE level as a tolerance marker in the follow up of egg allergy. 53 62
8034192 1994
16
[The production of B cell stimulating activity in peripheral blood mononuclear cells from allergic children with positive IgE RAST score to egg white]. 53 62
2053859 1991
17
Food allergy in Sri Lanka - A comparative study. 62
36474913 2022
18
Prospective evaluation of tolerance to unheated milk-boiled egg after baked milk-egg tolerance under 2 years. 62
35779844 2022
19
Avoiding avoidance in milk and egg allergy. 62
36464391 2022
20
Tree nut introduction in infants with peanut and/or egg allergy. 62
36347470 2022
21
Phenotyping of immediate-type food allergies based on 10 years of research: A latent class analysis. 62
36433852 2022
22
Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens. 62
36383680 2022
23
Early Peanut Introduction in Primary Care: Evaluation of a Multi-Component Intervention. 62
36410601 2022
24
Protease-digested egg-white products induce oral tolerance in mice but elicit little IgE production upon epicutaneous exposure. 62
35443911 2022
25
Bronchial hyperresponsiveness and asthma during oral immunotherapy for egg or peanut allergy in children. 62
36246730 2022
26
Delayed egg introduction beyond infancy and increased egg allergy risk in childhood. 62
36190149 2022
27
An Origami Paper-Based Biosensor for Allergen Detection by Chemiluminescence Immunoassay on Magnetic Microbeads. 62
36290961 2022
28
Home Introduction of Baked Egg After Oral Food Challenge. 62
36243403 2022
29
Single-dose AAV vector gene immunotherapy to treat food allergy. 62
35990748 2022
30
Association of egg protein levels in dust with allergy status and related factors. 62
36168729 2022
31
The natural history of peanut and egg allergy in children up to age 6 years in the HealthNuts population-based longitudinal study. 62
35597613 2022
32
Potential of Egg as Complementary Food to Improve Nutrient Intake and Dietary Diversity. 62
36014905 2022
33
The adverse reactions to vaccines practice parameter 10 years on-what have we learned? 62
35101646 2022
34
Prevalence of IgE-mediated cow milk, egg, and peanut allergy in young Singapore children. 62
35966156 2022
35
Patterns of allergenic food introduction in Los Angeles inner-city children. 62
35966161 2022
36
Early food intervention and skin emollients to prevent food allergy in young children (PreventADALL): a factorial, multicentre, cluster-randomised trial. 62
35753340 2022
37
Allergen immunotherapy and/or biologicals for IgE-mediated food allergy: A systematic review and meta-analysis. 62
35001400 2022
38
B-cell receptor physical properties affect relative IgG1 and IgE responses in mouse egg allergy. 62
36114245 2022
39
Egg Allergy in Children and Weaning Diet. 62
35458102 2022
40
Allergen-specific T cells and clinical features of food allergy: Lessons from CoFAR immunotherapy cohorts. 62
34653515 2022
41
Is oral food challenge useful to avoid complete elimination in Japanese patients diagnosed with or suspected of having IgE-dependent hen's egg allergy? A systematic review. 62
34663557 2022
42
Dietary Diversity during Early Infancy Increases Microbial Diversity and Prevents Egg Allergy in High-Risk Infants. 62
35573149 2022
43
BSACI 2021 guideline for the management of egg allergy. 62
34862823 2022
44
BSACI 2021 guideline for the management of egg allergy. 62
34808029 2022
45
Is hen's egg allergy decreasing among Japanese children in nurseries? 62
35261340 2022
46
Clinical cross-reactivity to quail's egg in patients with hen's egg allergy. 62
35338729 2022
47
Assessment of egg and milk allergies among Indians by revalidating a food allergy predictive model. 62
35399818 2022
48
Food allergy and hypersensitivity reactions in children and adults-A review. 62
34875122 2022
49
The association between environmental greenness and the risk of food allergy: A population-based study in Melbourne, Australia. 62
35212044 2022
50
[ANAPHYLACTIC REACTION TO LYSOZYME CHLORIDE-INCLUDING DEODORANT SPRAY IN A CHILD WITH EGG ALLERGY]. 62
35296604 2022

Variations for Egg Allergy

Expression for Egg Allergy

Search GEO for disease gene expression data for Egg Allergy.

Pathways for Egg Allergy

Pathways related to Egg Allergy according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.16 TSLP IL5 IL4 IL13 IL10 CD4
2
Show member pathways
13.13 IL5 IL4 IL13 IL10 CD4 CCR6
3 12.4 IL4 IL10 FOXP3 ENPP3
4
Show member pathways
11.98 IL5 IL4 IL10 CD4
5 11.84 CD4 IL10 IL4 IL5
6 11.79 IL4 IL13 IL10
7 11.77 IL5 IL4 IL13 IL10 FOXP3
8 11.63 IL13 IL4 IL5
9 11.57 IL4 FOXP3 CD4
10 11.56 IL5 IL4 IL10
11
Show member pathways
11.54 IL5 IL4 FOXP3
12 11.5 IL5 IL4 IL13
13 11.46 IL5 IL4 IL10
14
Show member pathways
11.43 FOXP3 IL10 IL13 IL4 IL5
15 11.39 IL4 IL10 CD4
16 11.24 TSLP IL5 IL4 IL13
17 11.1 IL5 IL4 IL13 IL10
18 11.1 IL5 IL4 IL13 IL10 FOXP3 CD4
19 11.07 TSLP IL5 IL4 IL13 IL10 CD4
20 11.04 IL5 IL4 IL13 IL10
21 11.02 IL5 IL4 IL13 IL10 CD4
22 10.77 IL4 CD4
23 10.71 IL5 IL4 IL13

GO Terms for Egg Allergy

Cellular components related to Egg Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.58 TSLP PTGDS LALBA IL5 IL4 IL13

Biological processes related to Egg Allergy according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.11 TSLP PDCL LALBA IL5 IL4 IL13
2 T cell activation GO:0042110 9.99 IL4 FOXP3 CD4
3 positive regulation of B cell proliferation GO:0030890 9.95 IL5 IL4 IL13
4 positive regulation of interleukin-10 production GO:0032733 9.93 IL13 IL4 TSLP
5 negative regulation of endothelial cell apoptotic process GO:2000352 9.85 IL4 IL13 IL10
6 negative regulation of T-helper 17 cell differentiation GO:2000320 9.83 IL4 FOXP3
7 type 2 immune response GO:0042092 9.8 IL4 IL10
8 immune response GO:0006955 9.77 CCR6 CD4 IGHE IL10 IL13 IL4
9 regulation of isotype switching GO:0045191 9.73 IL4 IL10
10 positive regulation of immunoglobulin production GO:0002639 9.73 IL10 IL13 IL5
11 negative regulation of chronic inflammatory response GO:0002677 9.71 IL4 FOXP3
12 negative regulation of complement-dependent cytotoxicity GO:1903660 9.62 IL4 IL13
13 negative regulation of inflammatory response GO:0050728 9.28 IL4 IL13 IL10 FOXP3 ENPP3

Molecular functions related to Egg Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 TSLP IL5 IL4 IL13 IL10

Sources for Egg Allergy

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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