Ehrlich Tumor Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Ehrlich Tumor Carcinoma

MalaCards integrated aliases for Ehrlich Tumor Carcinoma:

Name: Ehrlich Tumor Carcinoma ¹² ¹⁵ ¹⁷

Carcinoma, Ehrlich Tumor ⁴³ ⁷¹

Ehrlich's Tumor ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5050

MeSH ⁴³ D002286

EFO ¹⁷ EFO_1000913

UMLS ⁷¹ C0007125

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Summaries for Ehrlich Tumor Carcinoma

MalaCards based summary : Ehrlich Tumor Carcinoma, also known as carcinoma, ehrlich tumor, is related to chronic ulcer of skin and lymphosarcoma. An important gene associated with Ehrlich Tumor Carcinoma is H2BC7 (H2B Clustered Histone 7), and among its related pathways/superpathways are Gene Expression and Metabolism of proteins. Affiliated tissues include skin.

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Related Diseases for Ehrlich Tumor Carcinoma

Diseases related to Ehrlich Tumor Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	chronic ulcer of skin	10.1
2	lymphosarcoma	10.1

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Symptoms & Phenotypes for Ehrlich Tumor Carcinoma

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Drugs & Therapeutics for Ehrlich Tumor Carcinoma

Search Clinical Trials , NIH Clinical Center for Ehrlich Tumor Carcinoma

Cochrane evidence based reviews: carcinoma, ehrlich tumor

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Genetic Tests for Ehrlich Tumor Carcinoma

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Anatomical Context for Ehrlich Tumor Carcinoma

MalaCards organs/tissues related to Ehrlich Tumor Carcinoma:

⁴⁰

Skin

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Publications for Ehrlich Tumor Carcinoma

Articles related to Ehrlich Tumor Carcinoma:

#	Title	Authors	PMID	Year
1	[Effect of sodium fluoroacetate on Ehrlich solid tumor and autochthonous sarcoma growth in mice]. ⁶¹	Anikin IV...Anisimov VN	24624791	2013
2	[Membrane structures in the nuclei of Ehrlich tumor carcinoma ascites cells following effect of cyclophosphamide (endoxan)]. ⁶¹	Merker HJ...Liss E	6011267	1966

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Genes for Ehrlich Tumor Carcinoma

Genes related to Ehrlich Tumor Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	H2BC7	H2B Clustered Histone 7	Protein Coding	6.42	DISEASES inferred ¹⁵
2	H2BC4	H2B Clustered Histone 4	Protein Coding	6.4	DISEASES inferred ¹⁵
3	H2BC10	H2B Clustered Histone 10	Protein Coding	6.37	DISEASES inferred ¹⁵
4	H2BC6	H2B Clustered Histone 6	Protein Coding	6.31	DISEASES inferred ¹⁵
5	H2BC8	H2B Clustered Histone 8	Protein Coding	6.17	DISEASES inferred ¹⁵
6	KIF20A	Kinesin Family Member 20A	Protein Coding	5.82	DISEASES inferred ¹⁵
7	CYP1A1	Cytochrome P450 Family 1 Subfamily A Member 1	Protein Coding	5.31	DISEASES inferred ¹⁵

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Variations for Ehrlich Tumor Carcinoma

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Expression for Ehrlich Tumor Carcinoma

Search GEO for disease gene expression data for Ehrlich Tumor Carcinoma.

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Pathways for Ehrlich Tumor Carcinoma

Pathways related to Ehrlich Tumor Carcinoma according to GeneCards Suite gene sharing:

(show all 19)

#	Super pathways	Score	Top Affiliating Genes
1	Gene Expression ⁶⁵ Show member pathways Generic Transcription Pathway ⁶⁵	13.41	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
2	Metabolism of proteins ⁶⁵ Show member pathways Post-translational protein modification ⁶⁵	13.4	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
3	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 ⁶⁵ Show member pathways Activation of anterior HOX genes in hindbrain development during early embryogenesis ⁶⁵ Activation of HOX genes during differentiation ⁶⁵ Alcoholism ³⁶ Amyloid fiber formation ⁶⁵ B-WICH complex positively regulates rRNA expression ⁶⁵ Condensation of Prophase Chromosomes ⁶⁵ DNA methylation ⁶⁵ Epigenetic regulation of gene expression ⁶⁵ ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression ⁶⁵ Formation of the beta-catenin-TCF transactivating complex ⁶⁵ HDACs deacetylate histones ⁶⁵ HDMs demethylate histones ⁶⁵ Negative epigenetic regulation of rRNA expression ⁶⁵ NoRC negatively regulates rRNA expression ⁶⁵ Positive epigenetic regulation of rRNA expression ⁶⁵ PRC2 methylates histones and DNA ⁶⁵ RHO GTPases activate PKNs ⁶⁵ RMTs methylate histone arginines ⁶⁵ RNA Polymerase I Chain Elongation ⁶⁵ RNA Polymerase I Promoter Clearance ⁶⁵ RNA Polymerase I Promoter Opening ⁶⁵ RNA Polymerase I Transcription ⁶⁵ RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription ⁶⁵ SIRT1 negatively regulates rRNA Expression ⁶⁵ Systemic lupus erythematosus ³⁶	13.38	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
4	Developmental Biology ⁶⁵ Show member pathways Axon guidance ⁶⁵	13.17	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
5	Cell Cycle, Mitotic ⁶⁵ Show member pathways Cell Cycle ⁶⁵ M Phase ⁶⁵	13.13	KIF20A H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
6	DNA Double-Strand Break Repair ⁶⁵ Show member pathways Chk1/Chk2(Cds1) mediated inactivation of Cyclin B-Cdk1 complex ⁶⁵ DNA damage_DNA-damage-induced responses ²² DNA Repair ⁶⁵ G2/M DNA damage checkpoint ⁶⁵ HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) ⁶⁵ HDR through MMEJ (alt-NHEJ) ⁶⁵ Homology Directed Repair ⁶⁵ Non-homologous end joining ¹ Non-homologous end-joining ³⁶ Processing of DNA double-strand break ends ⁶⁵	12.95	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
7	Cellular Senescence (REACTOME) ⁶⁵ Show member pathways Cellular responses to stress ⁶⁵ Oxidative Stress Induced Senescence ⁶⁵ Senescence-Associated Secretory Phenotype (SASP) ⁶⁵	12.88	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
8	Signaling by Rho GTPases ⁶⁵ Show member pathways RHO GTPase Effectors ⁶⁵	12.78	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
9	Chromatin organization ⁶⁵ Show member pathways Chromatin modifying enzymes ⁶⁵ HATs acetylate histones ⁶⁵	12.75	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
10	Signaling by Wnt ⁶⁵ Show member pathways TCF dependent signaling in response to WNT ⁶⁵	12.64	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
11	Deubiquitination ⁶⁵ Show member pathways Ub-specific processing proteases ⁶⁵	12.57	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
12	Mitotic Prophase ⁶⁵ Show member pathways Gene Silencing by RNA ⁶⁵ Golgi Cisternae Pericentriolar Stack Reorganization ⁶⁵ MASTL Facilitates Mitotic Progression ⁶⁵ Small interfering RNA (siRNA) biogenesis ⁶⁵ Transcriptional regulation by small RNAs ⁶⁵	12.45	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
13	Cell Cycle Checkpoints ⁶⁵ Show member pathways G2/M Checkpoints ⁶⁵	12.37	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
14	Chromosome Maintenance ⁶⁵ Show member pathways Deposition of new CENPA-containing nucleosomes at the centromere ⁶⁵ Nucleosome assembly ⁶⁵ Telomere Maintenance ⁶⁵	12.3	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
15	Meiosis ⁶⁵ Show member pathways Meiotic recombination ⁶⁵ Meiotic synapsis ⁶⁵	12.18	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
16	DNA Double Strand Break Response ⁶⁵ Show member pathways Nonhomologous End-Joining (NHEJ) ⁶⁵ Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks ⁶⁵ Sensing of DNA Double Strand Breaks ⁶⁵	12.01	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
17	DNA Damage/Telomere Stress Induced Senescence ⁶⁵ Show member pathways Formation of Senescence-Associated Heterochromatin Foci (SAHF) ⁶⁵ Packaging Of Telomere Ends ⁶⁵ Signal transduction Activin A signaling regulation ²²	11.9	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
18	Viral carcinogenesis ³⁶	11.66	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
19	Protein ubiquitination ⁶⁵ Show member pathways E3 ubiquitin ligases ubiquitinate target proteins ⁶⁵ Synthesis of active ubiquitin- roles of E1 and E2 enzymes ⁶⁵ Ubiquitination Cascade Pathway ⁶⁴	11.28	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10

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GO Terms for Ehrlich Tumor Carcinoma

Cellular components related to Ehrlich Tumor Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleoplasm	GO:0005654	9.73	KIF20A H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
2	extracellular exosome	GO:0070062	9.72	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
3	extracellular space	GO:0005615	9.55	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
4	chromosome	GO:0005694	9.35	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
5	nucleosome	GO:0000786	9.02	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10

Biological processes related to Ehrlich Tumor Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein ubiquitination	GO:0016567	9.8	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
2	defense response to bacterium	GO:0042742	9.77	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
3	nucleosome assembly	GO:0006334	9.72	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
4	defense response to Gram-positive bacterium	GO:0050830	9.65	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
5	antimicrobial humoral immune response mediated by antimicrobial peptide	GO:0061844	9.55	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
6	antibacterial humoral response	GO:0019731	9.35	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
7	innate immune response in mucosa	GO:0002227	9.02	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10

Molecular functions related to Ehrlich Tumor Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA binding	GO:0003677	9.55	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
2	identical protein binding	GO:0042802	9.35	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10
3	protein heterodimerization activity	GO:0046982	9.02	H2BC8 H2BC7 H2BC6 H2BC4 H2BC10

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