HE
MCID: EHR002
MIFTS: 42

Ehrlichiosis (HE)

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Ehrlichiosis

MalaCards integrated aliases for Ehrlichiosis:

Name: Ehrlichiosis 12 76 53 59 55 44 15 73
Human Ehrlichiosis 12 53 3 73
He 53

Characteristics:

Orphanet epidemiological data:

59
ehrlichiosis
Prevalence: 1-9/1000000 (United States); Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:10242
ICD10 33 A77.4 A77.40
ICD9CM 35 082.4 082.40
MeSH 44 D016873
SNOMED-CT 68 77361002
Orphanet 59 ORPHA1902
MESH via Orphanet 45 D016873
UMLS via Orphanet 74 C0085399
ICD10 via Orphanet 34 A48.8

Summaries for Ehrlichiosis

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in leukocyte, has material basis in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted by lone start stick and transmitted by black-legged tick respectively. The infection has symptom headache, has symptom muscle aches, has symptom fatigue and has symptom rash.

MalaCards based summary : Ehrlichiosis, also known as human ehrlichiosis, is related to human granulocytic anaplasmosis and human monocytic ehrlichiosis. An important gene associated with Ehrlichiosis is FUT7 (Fucosyltransferase 7), and among its related pathways/superpathways are amb2 Integrin signaling and Ferroptosis. Affiliated tissues include monocytes, testes and t cells, and related phenotypes are Mildly decreased CFP-tsO45G cell surface transport and immune system

CDC : 3 Ehrlichiosis is the general name used to describe diseases caused by the bacteria Ehrlichia chaffeensis, E. ewingii, or E. muris eauclairensis in the United States. These bacteria are spread to people primarily through the bite of infected ticks including the lone star tick (Amblyomma americanum) and the blacklegged tick (Ixodes scapularis).

Wikipedia : 76 Ehrlichiosis is a tickborne bacterial infection, caused by bacteria of the family Anaplasmataceae,... more...

Related Diseases for Ehrlichiosis

Diseases related to Ehrlichiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 human granulocytic anaplasmosis 32.1 TFRC SELPLG HSPD1 HGD FUT7 CYBB
2 human monocytic ehrlichiosis 12.6
3 sennetsu fever 11.7
4 tick infestation 11.4
5 lyme disease 10.5
6 babesiosis 10.4
7 pancytopenia 10.3
8 rocky mountain spotted fever 10.2
9 spotted fever 10.2
10 hemophagocytic lymphohistiocytosis 10.2
11 encephalitis 10.2
12 tick-borne encephalitis 10.1
13 thrombocytopenia 10.1
14 anemia, sideroblastic, 1 10.1 TFRC ACO1
15 thrombotic thrombocytopenic purpura 10.0
16 purpura 10.0
17 meningitis 10.0
18 microcytic anemia 9.9 TFRC ACO1
19 oral lichen planus 9.9 HSPD1 CASP3
20 lymphoma 9.9
21 bartonellosis 9.9
22 toxic shock syndrome 9.9
23 acute respiratory distress syndrome 9.9
24 prostate calculus 9.9 HGD CASP3
25 vascular disease 9.8 SELP HSPD1 CYBB
26 atrial standstill 1 9.8
27 cryoglobulinemia, familial mixed 9.8
28 malaria 9.8
29 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.8
30 pulmonary hypertension 9.8
31 adult respiratory distress syndrome 9.8
32 arthritis 9.8
33 b-cell lymphomas 9.8
34 glomerulonephritis 9.8
35 leukemia 9.8
36 neutropenia 9.8
37 sensorineural hearing loss 9.8
38 meningoencephalitis 9.8
39 q fever 9.8
40 respiratory failure 9.8
41 cat-scratch disease 9.8
42 tick paralysis 9.8
43 nephrotic syndrome 9.8
44 cryptococcosis 9.8
45 optic neuritis 9.8
46 chagas disease 9.8
47 aseptic meningitis 9.8
48 relapsing fever 9.8
49 diarrhea 9.8
50 coccidioidomycosis 9.8

Graphical network of the top 20 diseases related to Ehrlichiosis:



Diseases related to Ehrlichiosis

Symptoms & Phenotypes for Ehrlichiosis

GenomeRNAi Phenotypes related to Ehrlichiosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Mildly decreased CFP-tsO45G cell surface transport GR00360-A-1 9.28 ACO1 ANK1 CCDC58 DNASE1L1 FUT7 HGD

MGI Mouse Phenotypes related to Ehrlichiosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.56 ANK1 CASP3 CYBB FUT7 HGD SELP
2 renal/urinary system MP:0005367 9.1 ANK1 CASP3 CYBB HGD SELP SELPLG

Drugs & Therapeutics for Ehrlichiosis

Search Clinical Trials , NIH Clinical Center for Ehrlichiosis

Cochrane evidence based reviews: ehrlichiosis

Genetic Tests for Ehrlichiosis

Anatomical Context for Ehrlichiosis

MalaCards organs/tissues related to Ehrlichiosis:

41
Monocytes, Testes, T Cells, Bone, Neutrophil, Bone Marrow, B Cells

Publications for Ehrlichiosis

Articles related to Ehrlichiosis:

(show top 50) (show all 730)
# Title Authors Year
1
Relative Risk for Ehrlichiosis and Lyme Disease Where Vectors for Both Are Sympatric, Southeastern United States. ( 29350157 )
2018
2
Graft loss attributed to possible transfusion-transmitted ehrlichiosis following cord blood stem cell transplant. ( 29668040 )
2018
3
Is it a Drug or a Bug? A Case of Chemotherapy and Immune Modulators Complicating the Diagnosis of Ehrlichiosis. ( 30206467 )
2018
4
Prevalence of Canine Monocytic Ehrlichiosis in Canine Population Across India. ( 30242799 )
2018
5
Large-scale health disparities associated with Lyme disease and human monocytic ehrlichiosis in the United States, 2007-2013. ( 30261027 )
2018
6
Ehrlichiosis masquerading as thrombotic thrombocytopenic purpura. ( 30279260 )
2018
7
The relationship between ehrlichiosis and the development of hematologic malignancies. ( 30396493 )
2018
8
Ehrlichiosis presenting as severe sepsis and meningoencephalitis in an immunocompetent adult. ( 30425837 )
2018
9
Ehrlichiosis ( 28722995 )
2017
10
Clinical and hematobiochemical response in canine monocytic ehrlichiosis seropositive dogs of Punjab. ( 28344412 )
2017
11
Therapeutic management of canine ehrlichiosis with aid of blood transfusion: a case report. ( 28615848 )
2017
12
Tick-Borne Emerging Infections: Ehrlichiosis and Anaplasmosis. ( 28457353 )
2017
13
Canine Monocytic Ehrlichiosis among working dogs of organised kennels in India: A comprehensive analyses of clinico-pathology, serological and molecular epidemiological approach. ( 29254723 )
2017
14
Molecular prevalence and haemato-biochemical profile of canine monocytic ehrlichiosis in dogs in and around Hisar, Haryana, India. ( 28848253 )
2017
15
Cerebral haemorrhage as a clinical manifestation of human ehrlichiosis. ( 28751428 )
2017
16
Sudden sensorineural hearing loss in human monocytic ehrlichiosis. ( 28846788 )
2017
17
High-Dose Filgrastim Treatment of Nonregenerative Pancytopenia Associated With Chronic Canine Ehrlichiosis. ( 28750787 )
2017
18
Relative Risk for Ehrlichiosis and Lyme Disease in an Area Where Vectors for Both Are Sympatric, New Jersey, USA. ( 28518034 )
2017
19
Serum antioxidant capacity and oxidative damage in clinical and subclinical canine ehrlichiosis. ( 28628845 )
2017
20
Human monocytic ehrlichiosis complicated by hemophagocytic lymphohistiocytosis and multi-organ dysfunction syndrome. ( 27575459 )
2016
21
Interstitial pneumonia and pulmonary hypertension associated with suspected ehrlichiosis in a dog. ( 27388158 )
2016
22
Severe human monocytic ehrlichiosis presenting with altered mental status and seizures. ( 27758794 )
2016
23
Development of Structure-Based Vaccines for Ehrlichiosis. ( 27076151 )
2016
24
Acute phase protein and antioxidant responses in dogs with experimental acute monocytic ehrlichiosis treated with rifampicin. ( 26854345 )
2016
25
Ehrlichiosis in Household Dogs and Parasitized Ticks in Kerman-Iran: Preliminary Zoonotic Risk Assessment. ( 27308282 )
2016
26
Ehrlichiosis Induced Aseptic Meningitis and Second Degree Heart Block in an Adolescent Male. ( 27097347 )
2016
27
Undetermined Human Ehrlichiosis and Anaplasmosis in the United States, 2008-2012: A Catch-All for Passive Surveillance. ( 26621564 )
2016
28
Successful Treatment of Human Monocytic Ehrlichiosis with Rifampin. ( 26918212 )
2016
29
Use of Extracorporeal Support in Hemophagocytic Lymphohistiocytosis Secondary to Ehrlichiosis. ( 27633921 )
2016
30
Growth of Ehrlichia canis, the causative agent of canine monocytic ehrlichiosis, in vector and non-vector ixodid tick cell lines. ( 26837859 )
2016
31
Quantitative and qualitative leukocyte abnormalities in dogs with experimental and naturally occurring acute canine monocytic ehrlichiosis. ( 27142117 )
2016
32
Increasing Incidence of Ehrlichiosis in the United States: A Summary of National Surveillance of Ehrlichia chaffeensis and Ehrlichia ewingii Infections in the United States, 2008-2012. ( 26621561 )
2016
33
Evaluation of clinical, biochemical and haematological markers in natural infection of canine monocytic ehrlichiosis. ( 27876946 )
2016
34
Fatal Monocytic Ehrlichiosis in Woman, Mexico, 2013. ( 27088220 )
2016
35
1217: EXTRACORPOREAL MEMBRANE OXYGENATION FOR HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS SECONDARY TO EHRLICHIOSIS. ( 26570878 )
2015
36
Diagnosis and incidence risk of clinical canine monocytic ehrlichiosis under field conditions in Southern Europe. ( 25561342 )
2015
37
Perspectives on the pathogenesis and treatment of canine monocytic ehrlichiosis (Ehrlichia canis). ( 25957922 )
2015
38
Comparative Evaluation of the Vector Competence of Four South American Populations of the Rhipicephalus sanguineus Group for the Bacterium Ehrlichia canis, the Agent of Canine Monocytic Ehrlichiosis. ( 26414283 )
2015
39
Butyrylcholinesterase as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis. ( 26616656 )
2015
40
Clinical determinants of Lyme borreliosis, babesiosis, bartonellosis, anaplasmosis, and ehrlichiosis in an Australian cohort. ( 25565883 )
2015
41
Hematobiochemical changes in ehrlichiosis in dogs of Anand region, Gujarat. ( 27065635 )
2015
42
Comparison of the acute phase protein and antioxidant responses in dogs vaccinated against canine monocytic ehrlichiosis and naive-challenged dogs. ( 25888870 )
2015
43
Serological and molecular analysis of feline vector-borne anaplasmosis and ehrlichiosis using species-specific peptides and PCR. ( 26062723 )
2015
44
Hemophagocytic lymphohistiocytosis induced by monocytic ehrlichiosis. ( 25449215 )
2015
45
The efficacy of a generic doxycycline tablet in the treatment of canine monocytic ehrlichiosis. ( 26018824 )
2015
46
Guideline for veterinary practitioners on canine ehrlichiosis and anaplasmosis in Europe. ( 25649069 )
2015
47
A Tick Vector Transmission Model of Monocytotropic Ehrlichiosis. ( 25737562 )
2015
48
Synovial fluid cytology in experimental acute canine monocytic ehrlichiosis (Ehrlichia canis). ( 25770893 )
2015
49
Canine ehrlichiosis: prevalence and epidemiology in northeast Brazil. ( 26083691 )
2015
50
The perils of country life: human monocytic ehrlichiosis. ( 25912197 )
2015

Variations for Ehrlichiosis

Expression for Ehrlichiosis

Search GEO for disease gene expression data for Ehrlichiosis.

Pathways for Ehrlichiosis

Pathways related to Ehrlichiosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.84 SELP SELPLG
2 10.56 CYBB TFRC
3 9.7 ACO1 TFRC

GO Terms for Ehrlichiosis

Biological processes related to Ehrlichiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.13 CASP3 HSPD1 SELP
2 leukocyte tethering or rolling GO:0050901 8.62 SELP SELPLG

Molecular functions related to Ehrlichiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.62 HSPD1 SELP

Sources for Ehrlichiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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