MCID: EHR002
MIFTS: 42

Ehrlichiosis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Ehrlichiosis

MalaCards integrated aliases for Ehrlichiosis:

Name: Ehrlichiosis 12 76 53 59 55 44 15 73
Human Ehrlichiosis 12 53 3 73
He 53

Characteristics:

Orphanet epidemiological data:

59
ehrlichiosis
Prevalence: 1-9/1000000 (United States); Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:10242
ICD10 33 A77.4 A77.40
ICD9CM 35 082.4 082.40
MeSH 44 D016873
SNOMED-CT 68 77361002
Orphanet 59 ORPHA1902
MESH via Orphanet 45 D016873
UMLS via Orphanet 74 C0085399
ICD10 via Orphanet 34 A48.8

Summaries for Ehrlichiosis

CDC : 3 Ehrlichiosis is the general name used to describe several bacterial diseases that affect animals and humans. Human ehrlichiosisis a disease caused by at least three different ehrlichial species in the United States: Ehrlichia chaffeensis, Ehrlichia ewingii, and a third Ehrlichia species provisionally called Ehrlichia muris-like (EML). Ehrlichiae are transmitted to humans by the bite of an infected tick. The lone star tick (Amblyomma americanum) is the primary vector of both Ehrlichia chaffeensis and Ehrlichia ewingii in the United States. Typical symptoms include: fever, headache, fatigue, and muscle aches. Usually, these symptoms occur within 1-2 weeks following a tick bite. Ehrlichios is diagnosed based on symptoms, clinical presentation, and later confirmed with specialized laboratory tests. The first line treatment for adults and children of all ages is doxycycline.  Ehrlichiosis and other tickborne diseases can be prevented.

MalaCards based summary : Ehrlichiosis, also known as human ehrlichiosis, is related to human granulocytic anaplasmosis and bartonellosis. An important gene associated with Ehrlichiosis is FUT7 (Fucosyltransferase 7), and among its related pathways/superpathways are Toxoplasmosis and Cell adhesion molecules (CAMs). Affiliated tissues include monocytes, testes and t cells, and related phenotypes are Mildly decreased CFP-tsO45G cell surface transport and cellular

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in leukocyte, has material basis in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted by lone start stick and transmitted by black-legged tick respectively. The infection has symptom headache, has symptom muscle aches, has symptom fatigue and has symptom rash.

Wikipedia : 76 Ehrlichiosis is a tickborne bacterial infection, caused by bacteria of the family Anaplasmataceae,... more...

Related Diseases for Ehrlichiosis

Diseases related to Ehrlichiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 human granulocytic anaplasmosis 29.8 ANK1 CD40LG CYBB FUT7 HSPD1 SELPLG
2 bartonellosis 29.3 CD40LG HSPD1
3 cat-scratch disease 29.1 CD40LG HSPD1
4 malaria 28.0 CASP3 CD40LG SELP TFRC
5 human monocytic ehrlichiosis 12.4
6 sennetsu fever 11.5
7 tick infestation 11.2
8 anemia, sideroblastic, 1 10.3 ACO1 TFRC
9 lyme disease 10.3
10 babesiosis 10.3
11 rocky mountain spotted fever 10.1
12 spotted fever 10.1
13 heparin-induced thrombocytopenia 10.0 CD40LG SELP
14 hemophagocytic lymphohistiocytosis 10.0
15 encephalitis 10.0
16 thrombocytopenia due to platelet alloimmunization 10.0 CD40LG SELP
17 tick-borne encephalitis 10.0
18 primary thrombocytopenia 10.0 CD40LG SELP
19 pustulosis palmaris et plantaris 10.0 CD40LG SELPLG
20 legg-calve-perthes disease 10.0 CD40LG SELP
21 heterophyiasis 9.9 CASP3 CD40LG
22 hemorrhagic fever 9.9 CD40LG TFRC
23 thrombocytopenia 9.9
24 oral lichen planus 9.9 CASP3 HSPD1
25 hepatitis 9.8
26 lymphoma 9.8
27 pancytopenia 9.8
28 cerebritis 9.8
29 meningitis 9.8
30 acute respiratory distress syndrome 9.8
31 fallopian tube disease 9.8 CD40LG HSPD1
32 salpingitis 9.7 CD40LG HSPD1
33 urethritis 9.7 CD40LG HSPD1
34 idiopathic neutropenia 9.7 CASP3 CD40LG
35 endocardium disease 9.6 CD40LG HSPD1
36 atrial standstill 1 9.6
37 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.6
38 pulmonary hypertension 9.6
39 adult respiratory distress syndrome 9.6
40 arthritis 9.6
41 b-cell lymphomas 9.6
42 leukemia 9.6
43 neutropenia 9.6
44 sensorineural hearing loss 9.6
45 thrombotic thrombocytopenic purpura 9.6
46 q fever 9.6
47 respiratory failure 9.6
48 tick paralysis 9.6
49 nephrotic syndrome 9.6
50 optic neuritis 9.6

Graphical network of the top 20 diseases related to Ehrlichiosis:



Diseases related to Ehrlichiosis

Symptoms & Phenotypes for Ehrlichiosis

GenomeRNAi Phenotypes related to Ehrlichiosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Mildly decreased CFP-tsO45G cell surface transport GR00360-A-1 9.28 ACO1 ANK1 CCDC58 CD40LG DNASE1L1 FUT7

MGI Mouse Phenotypes related to Ehrlichiosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 SELPLG CD40LG TFRC CYBB FUT7 HSPD1
2 cardiovascular system MP:0005385 9.95 CD40LG TFRC CYBB FUT7 ANK1 SELP
3 hematopoietic system MP:0005397 9.92 CD40LG TFRC CYBB FUT7 ANK1 SELP
4 immune system MP:0005387 9.86 SELPLG CD40LG TFRC CYBB FUT7 ANK1
5 integument MP:0010771 9.63 CASP3 SELPLG CD40LG TFRC ANK1 SELP
6 mortality/aging MP:0010768 9.61 SELPLG CD40LG TFRC CYBB ACO1 HSPD1
7 renal/urinary system MP:0005367 9.1 CD40LG CYBB ANK1 SELP CASP3 SELPLG

Drugs & Therapeutics for Ehrlichiosis

Search Clinical Trials , NIH Clinical Center for Ehrlichiosis

Cochrane evidence based reviews: ehrlichiosis

Genetic Tests for Ehrlichiosis

Anatomical Context for Ehrlichiosis

MalaCards organs/tissues related to Ehrlichiosis:

41
Monocytes, Testes, T Cells, Neutrophil, Bone Marrow, Bone, Liver

Publications for Ehrlichiosis

Articles related to Ehrlichiosis:

(show top 50) (show all 558)
# Title Authors Year
1
Relative Risk for Ehrlichiosis and Lyme Disease Where Vectors for Both Are Sympatric, Southeastern United States. ( 29350157 )
2018
2
Graft loss attributed to possible transfusion-transmitted ehrlichiosis following cord blood stem cell transplant. ( 29668040 )
2018
3
Ehrlichiosis ( 28722995 )
2017
4
Clinical and hematobiochemical response in canine monocytic ehrlichiosis seropositive dogs of Punjab. ( 28344412 )
2017
5
Therapeutic management of canine ehrlichiosis with aid of blood transfusion: a case report. ( 28615848 )
2017
6
Tick-Borne Emerging Infections: Ehrlichiosis and Anaplasmosis. ( 28457353 )
2017
7
Canine Monocytic Ehrlichiosis among working dogs of organised kennels in India: A comprehensive analyses of clinico-pathology, serological and molecular epidemiological approach. ( 29254723 )
2017
8
Molecular prevalence and haemato-biochemical profile of canine monocytic ehrlichiosis in dogs in and around Hisar, Haryana, India. ( 28848253 )
2017
9
Cerebral haemorrhage as a clinical manifestation of human ehrlichiosis. ( 28751428 )
2017
10
Sudden sensorineural hearing loss in human monocytic ehrlichiosis. ( 28846788 )
2017
11
High-Dose Filgrastim Treatment of Nonregenerative Pancytopenia Associated With Chronic Canine Ehrlichiosis. ( 28750787 )
2017
12
Relative Risk for Ehrlichiosis and Lyme Disease in an Area Where Vectors for Both Are Sympatric, New Jersey, USA. ( 28518034 )
2017
13
Serum antioxidant capacity and oxidative damage in clinical and subclinical canine ehrlichiosis. ( 28628845 )
2017
14
Human monocytic ehrlichiosis complicated by hemophagocytic lymphohistiocytosis and multi-organ dysfunction syndrome. ( 27575459 )
2016
15
Interstitial pneumonia and pulmonary hypertension associated with suspected ehrlichiosis in a dog. ( 27388158 )
2016
16
Severe human monocytic ehrlichiosis presenting with altered mental status and seizures. ( 27758794 )
2016
17
Development of Structure-Based Vaccines for Ehrlichiosis. ( 27076151 )
2016
18
Acute phase protein and antioxidant responses in dogs with experimental acute monocytic ehrlichiosis treated with rifampicin. ( 26854345 )
2016
19
Ehrlichiosis in Household Dogs and Parasitized Ticks in Kerman-Iran: Preliminary Zoonotic Risk Assessment. ( 27308282 )
2016
20
Ehrlichiosis Induced Aseptic Meningitis and Second Degree Heart Block in an Adolescent Male. ( 27097347 )
2016
21
Undetermined Human Ehrlichiosis and Anaplasmosis in the United States, 2008-2012: A Catch-All for Passive Surveillance. ( 26621564 )
2016
22
Successful Treatment of Human Monocytic Ehrlichiosis with Rifampin. ( 26918212 )
2016
23
Use of Extracorporeal Support in Hemophagocytic Lymphohistiocytosis Secondary to Ehrlichiosis. ( 27633921 )
2016
24
Growth of Ehrlichia canis, the causative agent of canine monocytic ehrlichiosis, in vector and non-vector ixodid tick cell lines. ( 26837859 )
2016
25
Quantitative and qualitative leukocyte abnormalities in dogs with experimental and naturally occurring acute canine monocytic ehrlichiosis. ( 27142117 )
2016
26
Increasing Incidence of Ehrlichiosis in the United States: A Summary of National Surveillance of Ehrlichia chaffeensis and Ehrlichia ewingii Infections in the United States, 2008-2012. ( 26621561 )
2016
27
Evaluation of clinical, biochemical and haematological markers in natural infection of canine monocytic ehrlichiosis. ( 27876946 )
2016
28
Fatal Monocytic Ehrlichiosis in Woman, Mexico, 2013. ( 27088220 )
2016
29
1217: EXTRACORPOREAL MEMBRANE OXYGENATION FOR HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS SECONDARY TO EHRLICHIOSIS. ( 26570878 )
2015
30
Diagnosis and incidence risk of clinical canine monocytic ehrlichiosis under field conditions in Southern Europe. ( 25561342 )
2015
31
Perspectives on the pathogenesis and treatment of canine monocytic ehrlichiosis (Ehrlichia canis). ( 25957922 )
2015
32
Comparative Evaluation of the Vector Competence of Four South American Populations of the Rhipicephalus sanguineus Group for the Bacterium Ehrlichia canis, the Agent of Canine Monocytic Ehrlichiosis. ( 26414283 )
2015
33
Butyrylcholinesterase as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis. ( 26616656 )
2015
34
Clinical determinants of Lyme borreliosis, babesiosis, bartonellosis, anaplasmosis, and ehrlichiosis in an Australian cohort. ( 25565883 )
2015
35
Hematobiochemical changes in ehrlichiosis in dogs of Anand region, Gujarat. ( 27065635 )
2015
36
Comparison of the acute phase protein and antioxidant responses in dogs vaccinated against canine monocytic ehrlichiosis and naive-challenged dogs. ( 25888870 )
2015
37
Serological and molecular analysis of feline vector-borne anaplasmosis and ehrlichiosis using species-specific peptides and PCR. ( 26062723 )
2015
38
Hemophagocytic lymphohistiocytosis induced by monocytic ehrlichiosis. ( 25449215 )
2015
39
The efficacy of a generic doxycycline tablet in the treatment of canine monocytic ehrlichiosis. ( 26018824 )
2015
40
Guideline for veterinary practitioners on canine ehrlichiosis and anaplasmosis in Europe. ( 25649069 )
2015
41
A Tick Vector Transmission Model of Monocytotropic Ehrlichiosis. ( 25737562 )
2015
42
Synovial fluid cytology in experimental acute canine monocytic ehrlichiosis (Ehrlichia canis). ( 25770893 )
2015
43
Canine ehrlichiosis: prevalence and epidemiology in northeast Brazil. ( 26083691 )
2015
44
The perils of country life: human monocytic ehrlichiosis. ( 25912197 )
2015
45
First record of autochthonous canine ehrlichiosis caused by Ehrlichia canis in Romania. ( 25867940 )
2015
46
Geographical and Temporal Correlations in the Incidence of Lyme Disease, RMSF, Ehrlichiosis, and Coccidioidomycosis with Search Data. ( 25756797 )
2015
47
Type I interferons promote severe disease in a mouse model of lethal ehrlichiosis. ( 24491580 )
2014
48
Clinical history and hematological findings among canines with monocytic ehrlichiosis. ( 24964665 )
2014
49
Sinus Bradycardia: Can We Blame Ehrlichiosis? ( 25232718 )
2014
50
Acute respiratory distress syndrome in human granulocytic ehrlichiosis. ( 25672061 )
2014

Variations for Ehrlichiosis

Expression for Ehrlichiosis

Search GEO for disease gene expression data for Ehrlichiosis.

Pathways for Ehrlichiosis

Pathways related to Ehrlichiosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.6 CASP3 CD40LG CYBB
2 11.29 CD40LG SELP SELPLG
3 10.86 CYBB TFRC
4 9.7 ACO1 TFRC

GO Terms for Ehrlichiosis

Biological processes related to Ehrlichiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell proliferation GO:0042100 9.32 CD40LG HSPD1
2 leukocyte cell-cell adhesion GO:0007159 9.26 CD40LG SELP
3 positive regulation of interleukin-12 production GO:0032735 9.16 CD40LG HSPD1
4 positive regulation of interleukin-10 production GO:0032733 8.96 CD40LG HSPD1
5 leukocyte tethering or rolling GO:0050901 8.62 SELP SELPLG

Molecular functions related to Ehrlichiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.62 HSPD1 SELP

Sources for Ehrlichiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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