MCID: EHR002
MIFTS: 40

Ehrlichiosis

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Ehrlichiosis

MalaCards integrated aliases for Ehrlichiosis:

Name: Ehrlichiosis 12 77 54 60 56 45 15 74
Human Ehrlichiosis 12 54 3 74
He 54

Characteristics:

Orphanet epidemiological data:

60
ehrlichiosis
Prevalence: 1-9/1000000 (United States); Age of onset: All ages;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:10242
ICD9CM 36 082.4 082.40
MeSH 45 D016873
SNOMED-CT 69 77361002
ICD10 34 A77.4 A77.40
MESH via Orphanet 46 D016873
ICD10 via Orphanet 35 A48.8
UMLS via Orphanet 75 C0085399
Orphanet 60 ORPHA1902

Summaries for Ehrlichiosis

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in leukocyte, has material basis in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted by lone start stick and transmitted by black-legged tick respectively. The infection has symptom headache, has symptom muscle aches, has symptom fatigue and has symptom rash.

MalaCards based summary : Ehrlichiosis, also known as human ehrlichiosis, is related to human granulocytic anaplasmosis and human monocytic ehrlichiosis. An important gene associated with Ehrlichiosis is FUT7 (Fucosyltransferase 7), and among its related pathways/superpathways are Spinal Cord Injury and Ferroptosis. Affiliated tissues include monocytes, testes and bone, and related phenotypes are hematopoietic system and cardiovascular system

CDC : 3 Ehrlichiosis is the general name used to describe diseases caused by the bacteria Ehrlichia chaffeensis, E. ewingii, or E. muris eauclairensis in the United States. These bacteria are spread to people primarily through the bite of infected ticks including the lone star tick (Amblyomma americanum) and the blacklegged tick (Ixodes scapularis).

Wikipedia : 77 Ehrlichiosis is a tickborne bacterial infection, caused by bacteria of the family Anaplasmataceae,... more...

Related Diseases for Ehrlichiosis

Diseases related to Ehrlichiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 human granulocytic anaplasmosis 31.8 ANK1 CYBB FUT7 HGD HSPD1 SELPLG
2 human monocytic ehrlichiosis 12.6
3 sennetsu fever 11.7
4 tick infestation 11.4
5 lyme disease 10.6
6 babesiosis 10.5
7 pancytopenia 10.3
8 rocky mountain spotted fever 10.3
9 spotted fever 10.3
10 hemophagocytic lymphohistiocytosis 10.2
11 encephalitis 10.2
12 tick-borne encephalitis 10.2
13 thrombocytopenia 10.1
14 thrombotic thrombocytopenic purpura 10.1
15 purpura 10.1
16 meningitis 10.1
17 anemia, sideroblastic, 1 10.1 ACO1 TFRC
18 neutropenia 10.0
19 lymphoma 10.0
20 bartonellosis 10.0
21 toxic shock syndrome 10.0
22 acute respiratory distress syndrome 10.0
23 prostate calculus 9.9 CASP3 HGD
24 atrial standstill 1 9.8
25 cryoglobulinemia, familial mixed 9.8
26 yemenite deaf-blind hypopigmentation syndrome 9.8
27 malaria 9.8
28 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.8
29 pulmonary hypertension 9.8
30 adult respiratory distress syndrome 9.8
31 arthritis 9.8
32 glomerulonephritis 9.8
33 leukemia 9.8
34 sensorineural hearing loss 9.8
35 meningoencephalitis 9.8
36 q fever 9.8
37 respiratory failure 9.8
38 cat-scratch disease 9.8
39 tick paralysis 9.8
40 nephrotic syndrome 9.8
41 cryptococcosis 9.8
42 optic neuritis 9.8
43 chagas disease 9.8
44 aseptic meningitis 9.8
45 relapsing fever 9.8
46 diarrhea 9.8
47 coccidioidomycosis 9.8
48 cholestasis 9.8
49 polyneuropathy 9.8
50 hypothyroidism 9.8

Graphical network of the top 20 diseases related to Ehrlichiosis:



Diseases related to Ehrlichiosis

Symptoms & Phenotypes for Ehrlichiosis

MGI Mouse Phenotypes related to Ehrlichiosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.92 ANK1 CASP3 CYBB FUT7 MMP12 SELP
2 cardiovascular system MP:0005385 9.91 ANK1 CASP3 CYBB FUT7 MMP12 SELP
3 homeostasis/metabolism MP:0005376 9.91 ACO1 ANK1 CASP3 CYBB HGD MMP12
4 immune system MP:0005387 9.81 ANK1 CASP3 CYBB FUT7 HGD MMP12
5 integument MP:0010771 9.43 ANK1 CASP3 MMP12 SELP SELPLG TFRC
6 renal/urinary system MP:0005367 9.1 ANK1 CASP3 CYBB HGD SELP SELPLG

Drugs & Therapeutics for Ehrlichiosis

Search Clinical Trials , NIH Clinical Center for Ehrlichiosis

Cochrane evidence based reviews: ehrlichiosis

Genetic Tests for Ehrlichiosis

Anatomical Context for Ehrlichiosis

MalaCards organs/tissues related to Ehrlichiosis:

42
Monocytes, Testes, Bone, T Cells, Neutrophil, Bone Marrow, Liver

Publications for Ehrlichiosis

Articles related to Ehrlichiosis:

(show top 50) (show all 731)
# Title Authors Year
1
Seasonality and trends in incidence of human ehrlichiosis in two Missouri ecoregions. ( 30868997 )
2019
2
Human ehrlichiosis at a tertiary-care academic medical center: Clinical associations and outcomes of transplant patients and patients with hemophagocytic lymphohistiocytosis. ( 30913447 )
2019
3
An update on the treatment of canine monocytic ehrlichiosis (Ehrlichia canis). ( 30902188 )
2019
4
Relative Risk for Ehrlichiosis and Lyme Disease Where Vectors for Both Are Sympatric, Southeastern United States. ( 29350157 )
2018
5
Graft loss attributed to possible transfusion-transmitted ehrlichiosis following cord blood stem cell transplant. ( 29668040 )
2018
6
Is it a Drug or a Bug? A Case of Chemotherapy and Immune Modulators Complicating the Diagnosis of Ehrlichiosis. ( 30206467 )
2018
7
Prevalence of Canine Monocytic Ehrlichiosis in Canine Population Across India. ( 30242799 )
2018
8
Large-scale health disparities associated with Lyme disease and human monocytic ehrlichiosis in the United States, 2007-2013. ( 30261027 )
2018
9
Ehrlichiosis masquerading as thrombotic thrombocytopenic purpura. ( 30279260 )
2018
10
The relationship between ehrlichiosis and the development of hematologic malignancies. ( 30396493 )
2018
11
Ehrlichiosis presenting as severe sepsis and meningoencephalitis in an immunocompetent adult. ( 30425837 )
2018
12
Prevalence of Ehrlichia canis (Rickettsiales: Ehrlichieae) DNA in Tissues From Rhipicephalus sanguineus (Acari: Ixodidae) Ticks in Areas Endemic for Canine Monocytic Ehrlichiosis in Brazil. ( 30566570 )
2018
13
Clinical and hematobiochemical response in canine monocytic ehrlichiosis seropositive dogs of Punjab. ( 28344412 )
2017
14
Tick-Borne Emerging Infections: Ehrlichiosis and Anaplasmosis. ( 28457353 )
2017
15
Relative Risk for Ehrlichiosis and Lyme Disease in an Area Where Vectors for Both Are Sympatric, New Jersey, USA. ( 28518034 )
2017
16
Therapeutic management of canine ehrlichiosis with aid of blood transfusion: a case report. ( 28615848 )
2017
17
Serum antioxidant capacity and oxidative damage in clinical and subclinical canine ehrlichiosis. ( 28628845 )
2017
18
High-Dose Filgrastim Treatment of Nonregenerative Pancytopenia Associated With Chronic Canine Ehrlichiosis. ( 28750787 )
2017
19
Cerebral haemorrhage as a clinical manifestation of human ehrlichiosis. ( 28751428 )
2017
20
Sudden sensorineural hearing loss in human monocytic ehrlichiosis. ( 28846788 )
2017
21
Molecular prevalence and haemato-biochemical profile of canine monocytic ehrlichiosis in dogs in and around Hisar, Haryana, India. ( 28848253 )
2017
22
Canine Monocytic Ehrlichiosis among working dogs of organised kennels in India: A comprehensive analyses of clinico-pathology, serological and molecular epidemiological approach. ( 29254723 )
2017
23
Evaluation of clinical, biochemical and haematological markers in natural infection of canine monocytic ehrlichiosis. ( 27876946 )
2016
24
Severe human monocytic ehrlichiosis presenting with altered mental status and seizures. ( 27758794 )
2016
25
Use of Extracorporeal Support in Hemophagocytic Lymphohistiocytosis Secondary to Ehrlichiosis. ( 27633921 )
2016
26
Human monocytic ehrlichiosis complicated by hemophagocytic lymphohistiocytosis and multi-organ dysfunction syndrome. ( 27575459 )
2016
27
Interstitial pneumonia and pulmonary hypertension associated with suspected ehrlichiosis in a dog. ( 27388158 )
2016
28
Ehrlichiosis in Household Dogs and Parasitized Ticks in Kerman-Iran: Preliminary Zoonotic Risk Assessment. ( 27308282 )
2016
29
Quantitative and qualitative leukocyte abnormalities in dogs with experimental and naturally occurring acute canine monocytic ehrlichiosis. ( 27142117 )
2016
30
Fatal Monocytic Ehrlichiosis in Woman, Mexico, 2013. ( 27088220 )
2016
31
Development of Structure-Based Vaccines for Ehrlichiosis. ( 27076151 )
2016
32
Successful Treatment of Human Monocytic Ehrlichiosis with Rifampin. ( 26918212 )
2016
33
Acute phase protein and antioxidant responses in dogs with experimental acute monocytic ehrlichiosis treated with rifampicin. ( 26854345 )
2016
34
Growth of Ehrlichia canis, the causative agent of canine monocytic ehrlichiosis, in vector and non-vector ixodid tick cell lines. ( 26837859 )
2016
35
Undetermined Human Ehrlichiosis and Anaplasmosis in the United States, 2008-2012: A Catch-All for Passive Surveillance. ( 26621564 )
2016
36
Increasing Incidence of Ehrlichiosis in the United States: A Summary of National Surveillance of Ehrlichia chaffeensis and Ehrlichia ewingii Infections in the United States, 2008-2012. ( 26621561 )
2016
37
Ehrlichiosis Induced Aseptic Meningitis and Second-Degree Heart Block in an Adolescent Male. ( 27097347 )
2016
38
Geographical and Temporal Correlations in the Incidence of Lyme Disease, RMSF, Ehrlichiosis, and Coccidioidomycosis with Search Data. ( 25756797 )
2015
39
Hematobiochemical changes in ehrlichiosis in dogs of Anand region, Gujarat. ( 27065635 )
2015
40
Butyrylcholinesterase as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis. ( 26616656 )
2015
41
Comparative Evaluation of the Vector Competence of Four South American Populations of the Rhipicephalus sanguineus Group for the Bacterium Ehrlichia canis, the Agent of Canine Monocytic Ehrlichiosis. ( 26414283 )
2015
42
Canine ehrlichiosis: prevalence and epidemiology in northeast Brazil. ( 26083691 )
2015
43
Serological and molecular analysis of feline vector-borne anaplasmosis and ehrlichiosis using species-specific peptides and PCR. ( 26062723 )
2015
44
The efficacy of a generic doxycycline tablet in the treatment of canine monocytic ehrlichiosis. ( 26018824 )
2015
45
Perspectives on the pathogenesis and treatment of canine monocytic ehrlichiosis (Ehrlichia canis). ( 25957922 )
2015
46
The perils of country life: human monocytic ehrlichiosis. ( 25912197 )
2015
47
Comparison of the acute phase protein and antioxidant responses in dogs vaccinated against canine monocytic ehrlichiosis and naive-challenged dogs. ( 25888870 )
2015
48
First record of autochthonous canine ehrlichiosis caused by Ehrlichia canis in Romania. ( 25867940 )
2015
49
Synovial fluid cytology in experimental acute canine monocytic ehrlichiosis (Ehrlichia canis). ( 25770893 )
2015
50
A Tick Vector Transmission Model of Monocytotropic Ehrlichiosis. ( 25737562 )
2015

Variations for Ehrlichiosis

Expression for Ehrlichiosis

Search GEO for disease gene expression data for Ehrlichiosis.

Pathways for Ehrlichiosis

Pathways related to Ehrlichiosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.21 CASP3 MMP12 SELP
2 10.76 CYBB TFRC
3 9.7 ACO1 TFRC

GO Terms for Ehrlichiosis

Biological processes related to Ehrlichiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 8.96 CASP3 SELP
2 response to hypoxia GO:0001666 8.85 CASP3
3 leukocyte tethering or rolling GO:0050901 8.62 SELP SELPLG

Molecular functions related to Ehrlichiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.62 HSPD1 SELP

Sources for Ehrlichiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....