HE
MCID: EHR002
MIFTS: 42

Ehrlichiosis (HE)

Categories: Blood diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Ehrlichiosis

MalaCards integrated aliases for Ehrlichiosis:

Name: Ehrlichiosis 12 74 52 58 54 43 15 71
Human Ehrlichiosis 12 52 71
Hey 17
He 52

Characteristics:

Orphanet epidemiological data:

58
ehrlichiosis
Prevalence: 1-9/1000000 (United States); Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:10242
ICD9CM 34 082.4 082.40
MeSH 43 D016873
SNOMED-CT 67 77361002
ICD10 32 A77.4 A77.40
MESH via Orphanet 44 D016873
ICD10 via Orphanet 33 A48.8
UMLS via Orphanet 72 C0085399
Orphanet 58 ORPHA1902
UMLS 71 C0085399 C0343771

Summaries for Ehrlichiosis

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in leukocyte, has material basis in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted by lone start stick and transmitted by black-legged tick respectively. The infection has symptom headache, has symptom muscle aches, has symptom fatigue and has symptom rash.

MalaCards based summary : Ehrlichiosis, also known as human ehrlichiosis, is related to human monocytic ehrlichiosis and human granulocytic anaplasmosis, and has symptoms including fatigue, headache and rash. An important gene associated with Ehrlichiosis is NSUN5 (NOP2/Sun RNA Methyltransferase 5), and among its related pathways/superpathways are Spinal Cord Injury and Iron metabolism in placenta. The drugs Insect Repellents and Protective Agents have been mentioned in the context of this disorder. Affiliated tissues include leukocyte, monocytes and testes, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 74 Ehrlichiosis is a tick-borne bacterial infection, caused by bacteria of the family Anaplasmataceae,... more...

Related Diseases for Ehrlichiosis

Diseases related to Ehrlichiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 228)
# Related Disease Score Top Affiliating Genes
1 human monocytic ehrlichiosis 33.7 TXNL1 MMP12 HSPD1 DNASE1L1
2 human granulocytic anaplasmosis 31.8 TFRC SELPLG MMP12 HSPD1 FUT7 EDC4
3 rocky mountain spotted fever 30.9 HSPD1 CD40LG
4 bartonellosis 30.3 HSPD1 CD40LG
5 cat-scratch disease 30.1 HSPD1 CD40LG
6 malaria 29.2 TFRC SELP HSPD1 CYBB CD40LG CASP3
7 sennetsu fever 12.0
8 tick infestation 11.6
9 hairy ears, y-linked 11.4
10 lyme disease 10.8
11 thrombocytopenia 10.8
12 neutropenia 10.8
13 pancytopenia 10.6
14 babesiosis 10.6
15 exanthem 10.5
16 spotted fever 10.5
17 lymphopenia 10.4
18 helix syndrome 10.4
19 suppurative lymphadenitis 10.4 RIT2 CYBB
20 headache 10.4
21 rickettsial disease 10.4
22 heterophyiasis 10.4 CD40LG CASP3
23 encephalitis 10.3
24 maxillary sinusitis 10.3 SELP CD40LG
25 tick-borne encephalitis 10.3
26 japanese spotted fever 10.3 HSPD1 CD40LG
27 inclusion conjunctivitis 10.3 HSPD1 CD40LG
28 chancroid 10.3 HSPD1 CD40LG
29 pustulosis palmaris et plantaris 10.3 SELPLG CD40LG
30 viral laryngitis 10.3 CD40LG ANK1
31 hemophagocytic lymphohistiocytosis 10.3
32 splenomegaly 10.3
33 posttransplant acute limbic encephalitis 10.3
34 cervical adenitis 10.2 HSPD1 CD40LG
35 retinitis pigmentosa 44 10.2
36 diarrhea 10.2
37 purpura 10.2
38 vasculitis 10.2
39 hypercholesterolemia, familial, 1 10.2
40 hypertriglyceridemia, familial 10.2
41 ovarian cancer 10.2
42 ataxia and polyneuropathy, adult-onset 10.2
43 respiratory failure 10.2
44 toxic shock syndrome 10.2
45 severe combined immunodeficiency 10.2
46 secondary hemophagocytic lymphohistiocytosis 10.2
47 chlamydia pneumonia 10.2 HSPD1 CD40LG
48 salpingitis 10.1 HSPD1 CD40LG
49 thrombotic thrombocytopenic purpura 10.1
50 acute kidney failure 10.1

Graphical network of the top 20 diseases related to Ehrlichiosis:



Diseases related to Ehrlichiosis

Symptoms & Phenotypes for Ehrlichiosis

Symptoms:

12
  • fatigue
  • headache
  • rash
  • muscle aches

GenomeRNAi Phenotypes related to Ehrlichiosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.13 MPP2
2 Decreased viability GR00221-A-2 10.13 MPP1 MPP2
3 Decreased viability GR00221-A-3 10.13 MPP2
4 Decreased viability GR00221-A-4 10.13 MPP1
5 Decreased viability GR00240-S-1 10.13 CD40LG PSMC6 SELPLG TFRC
6 Decreased viability GR00381-A-1 10.13 PSMC6
7 Decreased viability GR00402-S-2 10.13 ACO1 ANK1 CASP3 CD40LG CENPV CYBB
8 no effect GR00402-S-1 9.62 ACO1 ANK1 CASP3 CD40LG CENPV CYBB

MGI Mouse Phenotypes related to Ehrlichiosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 ANK1 CASP3 CD40LG CYBB EDC4 FUT7
2 immune system MP:0005387 9.36 ANK1 CASP3 CD40LG CYBB EDC4 FUT7

Drugs & Therapeutics for Ehrlichiosis

Drugs for Ehrlichiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Insect Repellents
2 Protective Agents
3 Eucalyptus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A School-Based Intervention to Reduce Lyme Disease Unknown status NCT00594997
2 A Single Group Trial to Determine the Complete Protection Time of an Insect Repellent Formulation Containing 30% Citriodiol® (Oil of Lemon Eucalyptus) Against Three Species of Ticks. Completed NCT03708120

Search NIH Clinical Center for Ehrlichiosis

Cochrane evidence based reviews: ehrlichiosis

Genetic Tests for Ehrlichiosis

Anatomical Context for Ehrlichiosis

The Foundational Model of Anatomy Ontology organs/tissues related to Ehrlichiosis:

19
Leukocyte

MalaCards organs/tissues related to Ehrlichiosis:

40
Monocytes, Testes, Bone, Neutrophil, T Cells, B Cells, Kidney

Publications for Ehrlichiosis

Articles related to Ehrlichiosis:

(show top 50) (show all 1665)
# Title Authors PMID Year
1
Molecular cloning and characterization of the 120-kilodalton protein gene of Ehrlichia canis and application of the recombinant 120-kilodalton protein for serodiagnosis of canine ehrlichiosis. 54 61
10618118 2000
2
Glycosylation of homologous immunodominant proteins of Ehrlichia chaffeensis and Ehrlichia canis. 54 61
10603362 2000
3
Prevalence of Infection and Co-Infection and Presence of Rickettsial Endosymbionts in Ixodes Scapularis (Acari: Ixodidae) in Connecticut, USA. 61
31971489 2020
4
Detection of Ehrlichia spp. and Anaplasma phagocytophilum in whole blood specimens using a duplex real-time PCR assay on the ARIES instrument. 61
32035897 2020
5
Genetic diversity of Anaplasma and Ehrlichia bacteria found in Dermacentor and Ixodes ticks in Mongolia. 61
31677968 2020
6
Ehrlichia canis TRP36 diversity in naturally infected-dogs from an urban area of Colombia. 61
31987818 2020
7
My Mother's Story: Tick Borne Ehrlichiosis and a Life Well-Lived. 61
31841654 2019
8
Phylogenetic profiling for zoonotic Ehrlichia spp. from ixodid ticks in the Eastern Cape, South Africa. 61
31880098 2019
9
Determining Effects of Winter Weather Conditions on Adult Amblyomma americanum (Acari: Ixodidae) Survival in Connecticut and Maine, USA. 61
31877783 2019
10
Knowledge and prevention of tickborne diseases among Hispanic and non-Hispanic residents of Maryland and Virginia. 61
31478316 2019
11
Chemiluminescent ELISA with multi-epitope proteins to improve the diagnosis of canine visceral leishmaniasis. 61
31685139 2019
12
Uncommon Ehrlichia canis infection associated with morulae in neutrophils from naturally infected dogs in Brazil. 61
31721463 2019
13
Isolation and Characterization of a Novel Pathogenic Strain of Ehrlichia minasensis. 61
31694172 2019
14
Human Case of Ehrlichia chaffeensis Infection, Taiwan. 61
31625863 2019
15
mTORC1-mediated polarization of M1 macrophages and their accumulation in the liver correlate with immunopathology in fatal ehrlichiosis. 61
31575880 2019
16
[Effectivity of diagnostic methods for the detection of human and canine monocytic ehrlichiosis]. 61
31859807 2019
17
Prevalence and risk factors associated with Ehrlichia infections in smallholder dairy cattle in Nairobi City County, Kenya. 61
31849422 2019
18
Predicted Northward Expansion of the Geographic Range of the Tick Vector Amblyomma americanum in North America under Future Climate Conditions. 61
31670575 2019
19
Atypical presentation of human ehrlichiosis and anaplasmosis in children in Israel. 61
31140643 2019
20
Detection of Rickettsiae, Borreliae, and Ehrlichiae in Ticks Collected from Walker County, Texas, 2017-2018. 61
31557808 2019
21
Acute acalculous cholecystitis as a manifestation of ehrlichiosis. 61
31155368 2019
22
Human ehrlichiosis at a tertiary-care academic medical center: Clinical associations and outcomes of transplant patients and patients with hemophagocytic lymphohistiocytosis. 61
30913447 2019
23
Ehrlichia Isolate from a Minnesota Tick: Characterization and Genetic Transformation. 61
31076433 2019
24
Conventional and Holter Electrocardiographic Assessment of Dogs Infected Naturally With Acute Canine Monocytic Ehrlichiosis. 61
31122685 2019
25
Performance of recombinant chimeric proteins in the serological diagnosis of Trypanosoma cruzi infection in dogs. 61
31242195 2019
26
Canine vector-borne disease: mapping and the accuracy of forecasting using big data from the veterinary community. 61
31895020 2019
27
Seroprevalence of Anaplasma phagocytophilum, Ehrlichia spp. and Borrelia burgdorferi infections in horses: first report from Northern Bulgaria - Short communication. 61
31238733 2019
28
Genetic diversity of Ehrlichia canis in dogs from Turkey inferred by TRP36 sequence analysis and phylogeny. 61
31174695 2019
29
TickPath Layerplex: adaptation of a real-time PCR methodology for the simultaneous detection and molecular surveillance of tick-borne pathogens. 61
31061487 2019
30
First detection of Ehrlichia minasensis in Hyalomma marginatum ticks collected from cattle in Corsica, France. 61
30663864 2019
31
Molecular characterization of Anaplasma and Ehrlichia in ixodid ticks and reservoir hosts from Palestine: a pilot survey. 61
30762295 2019
32
An update on the treatment of canine monocytic ehrlichiosis (Ehrlichia canis). 61
30902188 2019
33
Current Status of Tick-Borne Diseases in South Korea. 61
30328790 2019
34
Anti-Ehrlichia properties of the essential oil of Ageratum conyzoides L. and its interaction with doxycycline. 61
31037564 2019
35
Evidence of Ehrlichia chaffeensis in Argentina through molecular detection in marsh deer (Blastocerus dichotomus). 61
30619709 2019
36
Prevalence of Ehrlichia canis (Rickettsiales: Ehrlichieae) DNA in Tissues From Rhipicephalus sanguineus (Acari: Ixodidae) Ticks in Areas Endemic for Canine Monocytic Ehrlichiosis in Brazil. 61
30566570 2019
37
The rash with maculopapules and fever in adults. 61
30981291 2019
38
A review on the occurrence of companion vector-borne diseases in pet animals in Latin America. 61
30917860 2019
39
Clinicopathological findings in 41 dogs (2008-2018) naturally infected with Ehrlichia ewingii. 61
30604457 2019
40
Molecular identification of Ehrlichia ewingii in a polyarthritic Texas dog. 61
30624796 2019
41
Isolation and molecular detection of Ehrlichia species from ticks in western, central, and eastern Japan. 61
30501980 2019
42
Seasonality and trends in incidence of human ehrlichiosis in two Missouri ecoregions. 61
30868997 2019
43
Evaluation of heart rate variability and behavior of electrocardiographic parameters in dogs affected by chronic Monocytic Ehrlichiosis. 61
31125348 2019
44
[Molecular-genetic monitoring as the basis of modern epidemiological surveillance of tick-borne infections.] 61
31408595 2019
45
Emerging Roles of Autophagy and Inflammasome in Ehrlichiosis. 61
31134081 2019
46
Sequence Determinants Spanning -10 Motif and Spacer Region Implicated in Unique Ehrlichia chaffeensis Sigma 32-Dependent Promoter Activity of dnaK Gene. 61
31428069 2019
47
First report of human ehrlichiosis in Turkey. 61
31951339 2019
48
Molecular evidence of Ehrlichia canis and Anaplasma platys and the association of infections with hematological responses in naturally infected dogs in Kalasin, Thailand. 61
30936666 2019
49
Ehrlichia spp. infection in domestic cats from Rio de Janeiro State, southeast Brazil. 61
30892460 2019
50
Seroprevalence of Canine Ehrlichiosis and Microscopic Screening for Canine Babesiosis in Dogs in Harare, Zimbabwe, 2016-2017. 61
31885847 2019

Variations for Ehrlichiosis

Expression for Ehrlichiosis

Search GEO for disease gene expression data for Ehrlichiosis.

Pathways for Ehrlichiosis

Pathways related to Ehrlichiosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.21 SELP MMP12 CASP3
2 9.7 TFRC ACO1

GO Terms for Ehrlichiosis

Biological processes related to Ehrlichiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte tethering or rolling GO:0050901 8.62 SELPLG SELP

Sources for Ehrlichiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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