HE
MCID: EHR002
MIFTS: 44

Ehrlichiosis (HE)

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Ehrlichiosis

MalaCards integrated aliases for Ehrlichiosis:

Name: Ehrlichiosis 12 75 53 59 55 44 15 72
Human Ehrlichiosis 12 53 72
Hey 17
He 53

Characteristics:

Orphanet epidemiological data:

59
ehrlichiosis
Prevalence: 1-9/1000000 (United States); Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:10242
ICD9CM 35 082.4 082.40
MeSH 44 D016873
SNOMED-CT 68 77361002
ICD10 33 A77.4 A77.40
MESH via Orphanet 45 D016873
ICD10 via Orphanet 34 A48.8
UMLS via Orphanet 73 C0085399
Orphanet 59 ORPHA1902
UMLS 72 C0085399 C0343771

Summaries for Ehrlichiosis

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in leukocyte, has material basis in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted by lone start stick and transmitted by black-legged tick respectively. The infection has symptom headache, has symptom muscle aches, has symptom fatigue and has symptom rash.

MalaCards based summary : Ehrlichiosis, also known as human ehrlichiosis, is related to human granulocytic anaplasmosis and malaria. An important gene associated with Ehrlichiosis is FUT7 (Fucosyltransferase 7), and among its related pathways/superpathways are Toxoplasmosis and Cell adhesion molecules (CAMs). The drugs Protective Agents and Insect Repellents have been mentioned in the context of this disorder. Affiliated tissues include monocytes, testes and neutrophil, and related phenotypes are Mildly decreased CFP-tsO45G cell surface transport and cardiovascular system

Wikipedia : 75 Ehrlichiosis is a tick-borne bacterial infection, caused by bacteria of the family Anaplasmataceae,... more...

Related Diseases for Ehrlichiosis

Diseases related to Ehrlichiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 216)
# Related Disease Score Top Affiliating Genes
1 human granulocytic anaplasmosis 32.0 TFRC SELPLG HSPD1 FUT7 CYBB ANK1
2 malaria 28.9 TFRC SELP CD40LG CASP3
3 human monocytic ehrlichiosis 12.8
4 sennetsu fever 12.0
5 tick infestation 11.6
6 hairy ears, y-linked 11.4
7 lyme disease 10.8
8 thrombocytopenia 10.8
9 neutropenia 10.8
10 pancytopenia 10.6
11 babesiosis 10.6
12 exanthem 10.5
13 spotted fever 10.5
14 rocky mountain spotted fever 10.4
15 lymphopenia 10.4
16 helix syndrome 10.4
17 headache 10.4
18 rickettsial disease 10.4
19 encephalitis 10.3
20 tick-borne encephalitis 10.3
21 hemophagocytic lymphohistiocytosis 10.3
22 diarrhea 10.3
23 posttransplant acute limbic encephalitis 10.3
24 retinitis pigmentosa 44 10.2
25 purpura 10.2
26 vasculitis 10.2
27 acute respiratory distress syndrome 10.2
28 splenomegaly 10.2
29 hypercholesterolemia, familial, 1 10.2
30 hypertriglyceridemia, familial 10.2
31 ovarian cancer 10.2
32 intestine carcinoma in situ 10.2 SELPLG CD40LG
33 colon carcinoma in situ 10.2 SELPLG CD40LG
34 ataxia and polyneuropathy, adult-onset 10.2
35 respiratory failure 10.2
36 toxic shock syndrome 10.2
37 severe combined immunodeficiency 10.2
38 secondary hemophagocytic lymphohistiocytosis 10.2
39 primary thrombocytopenia 10.2 SELP CD40LG
40 pustulosis palmaris et plantaris 10.2 SELPLG CD40LG
41 thrombotic thrombocytopenic purpura 10.1
42 acute kidney failure 10.1
43 myocarditis 10.1
44 47,xyy 10.1
45 autism 10.1
46 ovary adenocarcinoma 10.1
47 rare disease in surgical orthopedic 10.1
48 legg-calve-perthes disease 10.1 SELP CD40LG
49 q fever 10.1
50 visual epilepsy 10.1

Graphical network of the top 20 diseases related to Ehrlichiosis:



Diseases related to Ehrlichiosis

Symptoms & Phenotypes for Ehrlichiosis

GenomeRNAi Phenotypes related to Ehrlichiosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Mildly decreased CFP-tsO45G cell surface transport GR00360-A-1 9.23 ACO1 ANK1 CD40LG DNASE1L1 FUT7 HSPD1

MGI Mouse Phenotypes related to Ehrlichiosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 ANK1 CASP3 CD40LG CYBB FUT7 MMP12
2 hematopoietic system MP:0005397 10.06 ANK1 CASP3 CD40LG CYBB FUT7 MMP12
3 cellular MP:0005384 10.03 CASP3 CD40LG CYBB FUT7 HSPD1 SELP
4 homeostasis/metabolism MP:0005376 10.02 ACO1 ANK1 CASP3 CD40LG CYBB MMP12
5 immune system MP:0005387 9.97 ANK1 CASP3 CD40LG CYBB FUT7 MMP12
6 mortality/aging MP:0010768 9.81 ACO1 ANK1 CASP3 CD40LG CYBB HSPD1
7 integument MP:0010771 9.8 ANK1 CASP3 CD40LG MMP12 SELP SELPLG
8 nervous system MP:0003631 9.56 ANK1 CASP3 CD40LG CYBB HSPD1 MMP12
9 renal/urinary system MP:0005367 9.1 ANK1 CASP3 CD40LG CYBB SELP SELPLG

Drugs & Therapeutics for Ehrlichiosis

Drugs for Ehrlichiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Protective Agents
2 Insect Repellents
3 Eucalyptus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A School-Based Intervention to Reduce Lyme Disease Unknown status NCT00594997
2 A Single Group Trial to Determine the Complete Protection Time of an Insect Repellent Formulation Containing 30% Citriodiol® (Oil of Lemon Eucalyptus) Against Three Species of Ticks. Recruiting NCT03708120

Search NIH Clinical Center for Ehrlichiosis

Cochrane evidence based reviews: ehrlichiosis

Genetic Tests for Ehrlichiosis

Anatomical Context for Ehrlichiosis

MalaCards organs/tissues related to Ehrlichiosis:

41
Monocytes, Testes, Neutrophil, T Cells, Bone, Bone Marrow, Whole Blood

Publications for Ehrlichiosis

Articles related to Ehrlichiosis:

(show top 50) (show all 1645)
# Title Authors PMID Year
1
Molecular cloning and characterization of the 120-kilodalton protein gene of Ehrlichia canis and application of the recombinant 120-kilodalton protein for serodiagnosis of canine ehrlichiosis. 9 38
10618118 2000
2
Glycosylation of homologous immunodominant proteins of Ehrlichia chaffeensis and Ehrlichia canis. 9 38
10603362 2000
3
Atypical presentation of human ehrlichiosis and anaplasmosis in children in Israel. 38
31140643 2019
4
Acute acalculous cholecystitis as a manifestation of ehrlichiosis. 38
31155368 2019
5
Human ehrlichiosis at a tertiary-care academic medical center: Clinical associations and outcomes of transplant patients and patients with hemophagocytic lymphohistiocytosis. 38
30913447 2019
6
Ehrlichia Isolate from a Minnesota Tick: Characterization and Genetic Transformation. 38
31076433 2019
7
Conventional and Holter Electrocardiographic Assessment of Dogs Infected Naturally With Acute Canine Monocytic Ehrlichiosis. 38
31122685 2019
8
Performance of recombinant chimeric proteins in the serological diagnosis of Trypanosoma cruzi infection in dogs. 38
31242195 2019
9
Seroprevalence of Anaplasma phagocytophilum, Ehrlichia spp. and Borrelia burgdorferi infections in horses: first report from Northern Bulgaria - Short communication. 38
31238733 2019
10
Genetic diversity of Ehrlichia canis in dogs from Turkey inferred by TRP36 sequence analysis and phylogeny. 38
31174695 2019
11
TickPath Layerplex: adaptation of a real-time PCR methodology for the simultaneous detection and molecular surveillance of tick-borne pathogens. 38
31061487 2019
12
First detection of Ehrlichia minasensis in Hyalomma marginatum ticks collected from cattle in Corsica, France. 38
30663864 2019
13
Molecular characterization of Anaplasma and Ehrlichia in ixodid ticks and reservoir hosts from Palestine: a pilot survey. 38
30762295 2019
14
An update on the treatment of canine monocytic ehrlichiosis (Ehrlichia canis). 38
30902188 2019
15
Current Status of Tick-Borne Diseases in South Korea. 38
30328790 2019
16
Anti-Ehrlichia properties of the essential oil of Ageratum conyzoides L. and its interaction with doxycycline. 38
31037564 2019
17
Prevalence of Ehrlichia canis (Rickettsiales: Ehrlichieae) DNA in Tissues From Rhipicephalus sanguineus (Acari: Ixodidae) Ticks in Areas Endemic for Canine Monocytic Ehrlichiosis in Brazil. 38
30566570 2019
18
Evidence of Ehrlichia chaffeensis in Argentina through molecular detection in marsh deer (Blastocerus dichotomus). 38
30619709 2019
19
The rash with maculopapules and fever in adults. 38
30981291 2019
20
A review on the occurrence of companion vector-borne diseases in pet animals in Latin America. 38
30917860 2019
21
Clinicopathological findings in 41 dogs (2008-2018) naturally infected with Ehrlichia ewingii. 38
30604457 2019
22
Molecular identification of Ehrlichia ewingii in a polyarthritic Texas dog. 38
30624796 2019
23
Lyme Neuroborreliosis - The Mystifying Pitfall: "Neuropathology and Current Therapeutics". 38
30919784 2019
24
Isolation and molecular detection of Ehrlichia species from ticks in western, central, and eastern Japan. 38
30501980 2019
25
Seasonality and trends in incidence of human ehrlichiosis in two Missouri ecoregions. 38
30868997 2019
26
Evaluation of heart rate variability and behavior of electrocardiographic parameters in dogs affected by chronic Monocytic Ehrlichiosis. 38
31125348 2019
27
[Molecular-genetic monitoring as the basis of modern epidemiological surveillance of tick-borne infections.] 38
31408595 2019
28
Emerging Roles of Autophagy and Inflammasome in Ehrlichiosis. 38
31134081 2019
29
Sequence Determinants Spanning -10 Motif and Spacer Region Implicated in Unique Ehrlichia chaffeensis Sigma 32-Dependent Promoter Activity of dnaK Gene. 38
31428069 2019
30
Molecular evidence of Ehrlichia canis and Anaplasma platys and the association of infections with hematological responses in naturally infected dogs in Kalasin, Thailand. 38
30936666 2019
31
Ehrlichia spp. infection in domestic cats from Rio de Janeiro State, southeast Brazil. 38
30892460 2019
32
Proteome Analysis Revealed Changes in Protein Expression Patterns Caused by Mutations in Ehrlichia chaffeensis. 38
30937288 2019
33
The relationship between ehrlichiosis and the development of hematologic malignancies. 38
30396493 2018
34
Serological and molecular diagnosis of Ehrlichia canis and associated risk factors in dogs domiciled in western Cuba. 38
31014724 2018
35
Molecular survey and characterization of Theileria annulata and Ehrlichia ruminantium in cattle from Northwest China. 38
29959093 2018
36
Serological Evidence of Borrelia burgdorferi, Anaplasma phagocytophilum and Ehrlichia Spp. Infections in Horses from Southeastern Bulgaria. 38
29969382 2018
37
Ehrlichiosis masquerading as thrombotic thrombocytopenic purpura. 38
30279260 2018
38
Intravascular large B-cell lymphoma: The Great Imitator. 38
30775328 2018
39
Survey and Phylogenetic Analysis of Rodents and Important Rodent-Borne Zoonotic Pathogens in Gedu, Bhutan. 38
30419740 2018
40
Prevalence of canine Babesia and Ehrlichia co-infection and the predictive value of haematology. 38
30326715 2018
41
Ehrlichiosis presenting as severe sepsis and meningoencephalitis in an immunocompetent adult. 38
30425837 2018
42
Tick-borne zoonoses in the Order Rickettsiales and Legionellales in Iran: A systematic review. 38
30204754 2018
43
Two different genogroups of Ehrlichia canis from dogs in Thailand using immunodominant protein genes. 38
29852293 2018
44
Successful Infection of Tick Cell Cultures of Rhipicephalus sanguineus (Tropical Lineage) with Ehrlichia canis. 38
30222504 2018
45
Graft loss attributed to possible transfusion-transmitted ehrlichiosis following cord blood stem cell transplant. 38
29668040 2018
46
Detection of Anaplasmataceae agents and co-infection with other tick-borne protozoa in dogs and Rhipicephalus sanguineus sensu lato ticks. 38
30073430 2018
47
Is it a Drug or a Bug? A Case of Chemotherapy and Immune Modulators Complicating the Diagnosis of Ehrlichiosis. 38
30206467 2018
48
Diagnosing Meat Allergy After Tick Bite Without Delay. 38
29986992 2018
49
Exposure to Ticks and their Pathogens in Northeast Missouri. 38
30228771 2018
50
Protein and DNA synthesis demonstrated in cell-free Ehrlichia chaffeensis organisms in axenic medium. 38
29915240 2018

Variations for Ehrlichiosis

Expression for Ehrlichiosis

Search GEO for disease gene expression data for Ehrlichiosis.

Pathways for Ehrlichiosis

Pathways related to Ehrlichiosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.71 CYBB CD40LG CASP3
2 11.5 SELPLG SELP CD40LG
3 11.21 SELP MMP12 CASP3
4 10.92 TFRC CYBB
5 9.7 TFRC ACO1

GO Terms for Ehrlichiosis

Biological processes related to Ehrlichiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell proliferation GO:0042100 9.4 HSPD1 CD40LG
2 leukocyte cell-cell adhesion GO:0007159 9.37 SELP CD40LG
3 response to lipopolysaccharide GO:0032496 9.26 SELP CASP3
4 positive regulation of interleukin-12 production GO:0032735 9.16 HSPD1 CD40LG
5 response to hypoxia GO:0001666 9.02 CASP3
6 positive regulation of interleukin-10 production GO:0032733 8.96 HSPD1 CD40LG
7 leukocyte tethering or rolling GO:0050901 8.62 SELPLG SELP

Molecular functions related to Ehrlichiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.62 SELP HSPD1

Sources for Ehrlichiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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