HE
MCID: EHR002
MIFTS: 42

Ehrlichiosis (HE)

Categories: Blood diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Ehrlichiosis

MalaCards integrated aliases for Ehrlichiosis:

Name: Ehrlichiosis 12 74 52 58 54 15 71
Human Ehrlichiosis 12 52 71
Hey 17
He 52

Characteristics:

Orphanet epidemiological data:

58
ehrlichiosis
Prevalence: 1-9/1000000 (United States); Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:10242
ICD9CM 34 082.4
ICD10 32 A77.4
MESH via Orphanet 44 D016873
ICD10 via Orphanet 33 A48.8
UMLS via Orphanet 72 C0085399
Orphanet 58 ORPHA1902
UMLS 71 C0085399 C0343771

Summaries for Ehrlichiosis

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in leukocyte, has material basis in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted by lone start stick and transmitted by black-legged tick respectively. The infection has symptom headache, has symptom muscle aches, has symptom fatigue and has symptom rash.

MalaCards based summary : Ehrlichiosis, also known as human ehrlichiosis, is related to human monocytic ehrlichiosis and human granulocytic anaplasmosis, and has symptoms including fatigue, headache and rash. An important gene associated with Ehrlichiosis is NSUN5 (NOP2/Sun RNA Methyltransferase 5), and among its related pathways/superpathways is Iron metabolism in placenta. The drugs Insect Repellents and Protective Agents have been mentioned in the context of this disorder. Affiliated tissues include leukocyte, monocytes and testes, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 74 Ehrlichiosis is a tick-borne bacterial infection, caused by bacteria of the family Anaplasmataceae,... more...

Related Diseases for Ehrlichiosis

Diseases related to Ehrlichiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 231)
# Related Disease Score Top Affiliating Genes
1 human monocytic ehrlichiosis 33.8 TXNL1 HSPD1 ETF1 DNASE1L1
2 human granulocytic anaplasmosis 32.5 TFRC SELPLG HSPD1 FUT7 EDC4 CYBB
3 rocky mountain spotted fever 30.9 HSPD1 CD40LG
4 bartonellosis 30.3 HSPD1 CD40LG
5 cat-scratch disease 30.1 HSPD1 CD40LG
6 malaria 29.3 TFRC SELP HSPD1 CYBB CD40LG CASP3
7 sennetsu fever 12.0
8 tick infestation 11.6
9 hairy ears, y-linked 11.5
10 lyme disease 10.8
11 thrombocytopenia 10.8
12 neutropenia 10.8
13 pancytopenia 10.6
14 babesiosis 10.6
15 exanthem 10.5
16 spotted fever 10.5
17 lymphopenia 10.4
18 helix syndrome 10.4
19 suppurative lymphadenitis 10.4 RIT2 CYBB
20 heterophyiasis 10.4 CD40LG CASP3
21 rickettsial disease 10.4
22 encephalitis 10.3
23 headache 10.3
24 hemophagocytic lymphohistiocytosis 10.3
25 tick-borne encephalitis 10.3
26 splenomegaly 10.3
27 inclusion conjunctivitis 10.3 HSPD1 CD40LG
28 bacillary angiomatosis 10.3 HSPD1 CD40LG
29 opportunistic bacterial infectious disease 10.3 HSPD1 CD40LG
30 posttransplant acute limbic encephalitis 10.3
31 maxillary sinusitis 10.3 SELP CD40LG
32 diffuse glomerulonephritis 10.3 CENPV CD40LG
33 chancroid 10.3 HSPD1 CD40LG
34 pustulosis palmaris et plantaris 10.3 SELPLG CD40LG
35 retinitis pigmentosa 44 10.2
36 purpura 10.2
37 vasculitis 10.2
38 hypercholesterolemia, familial, 1 10.2
39 ovarian cancer 10.2
40 cervical adenitis 10.2 HSPD1 CD40LG
41 spastic paraplegia 38, autosomal dominant 10.2 TFRC ACO1
42 ataxia and polyneuropathy, adult-onset 10.2
43 respiratory failure 10.2
44 diarrhea 10.2
45 toxic shock syndrome 10.2
46 severe combined immunodeficiency 10.2
47 secondary hemophagocytic lymphohistiocytosis 10.2
48 legionellosis 10.2 HSPD1 CD40LG CASP3
49 thrombotic thrombocytopenic purpura 10.1
50 acute kidney failure 10.1

Graphical network of the top 20 diseases related to Ehrlichiosis:



Diseases related to Ehrlichiosis

Symptoms & Phenotypes for Ehrlichiosis

Symptoms:

12
  • fatigue
  • headache
  • rash
  • muscle aches

GenomeRNAi Phenotypes related to Ehrlichiosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.64 MPP2
2 Decreased viability GR00221-A-2 9.64 MPP1 MPP2
3 Decreased viability GR00221-A-3 9.64 MPP2
4 Decreased viability GR00221-A-4 9.64 MPP1
5 Decreased viability GR00240-S-1 9.64 CD40LG ETF1 PSMC6 SELPLG TFRC
6 Decreased viability GR00249-S 9.64 CYBB PSMC6
7 Decreased viability GR00381-A-1 9.64 PSMC6
8 Decreased viability GR00386-A-1 9.64 ACO1 PSMC6 SELP
9 Decreased viability GR00402-S-2 9.64 ANK1 CYBB ETF1 PSMC6 TFRC

MGI Mouse Phenotypes related to Ehrlichiosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.4 ANK1 CASP3 CD40LG CYBB EDC4 FUT7

Drugs & Therapeutics for Ehrlichiosis

Drugs for Ehrlichiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Insect Repellents
2 Protective Agents
3 Eucalyptus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A School-Based Intervention to Reduce Lyme Disease Unknown status NCT00594997
2 A Single Group Trial to Determine the Complete Protection Time of an Insect Repellent Formulation Containing 30% Citriodiol® (Oil of Lemon Eucalyptus) Against Three Species of Ticks. Completed NCT03708120

Search NIH Clinical Center for Ehrlichiosis

Genetic Tests for Ehrlichiosis

Anatomical Context for Ehrlichiosis

The Foundational Model of Anatomy Ontology organs/tissues related to Ehrlichiosis:

19
Leukocyte

MalaCards organs/tissues related to Ehrlichiosis:

40
Monocytes, Testes, Neutrophil, T Cells, Bone Marrow, Bone, Whole Blood

Publications for Ehrlichiosis

Articles related to Ehrlichiosis:

(show top 50) (show all 1681)
# Title Authors PMID Year
1
Molecular cloning and characterization of the 120-kilodalton protein gene of Ehrlichia canis and application of the recombinant 120-kilodalton protein for serodiagnosis of canine ehrlichiosis. 54 61
10618118 2000
2
Glycosylation of homologous immunodominant proteins of Ehrlichia chaffeensis and Ehrlichia canis. 54 61
10603362 2000
3
Optimization and evaluation of a multiplex quantitative PCR assay for detection of nucleic acids in human blood from patients with spotted fever rickettsiosis, typhus rickettsiosis, scrub typhus, monocytic ehrlichiosis, and granulocytic anaplasmosis. 61
32493778 2020
4
Emerging tick-borne pathogens of public health importance: a mini-review. 61
32478654 2020
5
Tickborne Diseases: Diagnosis and Management. 61
32352736 2020
6
Committee Opinion No. 399: Management of Tick Bites and Lyme Disease During Pregnancy. 61
32414479 2020
7
Ehrlichiosis infection mimicking thrombotic microangiopathy syndrome early after kidney transplantation. 61
32358827 2020
8
My Mother's Story: Tick Borne Ehrlichiosis and a Life Well-Lived. 61
31841654 2020
9
High Performance of ELISA test using recombinant rLiNTPDase2 from Leishmania infantum: a Phase II diagnosis of Canine Visceral Leishmaniasis. 61
32450137 2020
10
Ehrlichia canis TRP36 diversity in naturally infected-dogs from an urban area of Colombia. 61
31987818 2020
11
Detection of Ehrlichia spp. and Anaplasma phagocytophilum in whole blood specimens using a duplex real-time PCR assay on the ARIES instrument. 61
32035897 2020
12
Association Between Exposure to Ehrlichia spp. and Risk of Developing Chronic Kidney Disease in Dogs. 61
32182116 2020
13
Phylogenetic profiling for zoonotic Ehrlichia spp. from ixodid ticks in the Eastern Cape, South Africa. 61
31880098 2020
14
Ehrlichiosis in a recent kidney transplant recipient: The repellent that did not repel! A case report and literature review of ehrlichiosis in solid organ transplant patients. 61
32306509 2020
15
Ehrlichia chaffeensis Uses an Invasin To Suppress Reactive Oxygen Species Generation by Macrophages via CD147-Dependent Inhibition of Vav1 To Block Rac1 Activation. 61
32317318 2020
16
Tick-Borne Diseases in the United States. 61
32232463 2020
17
Emerging and neglected zoonoses in transplant population. 61
32257849 2020
18
Prevalence of Infection and Co-Infection and Presence of Rickettsial Endosymbionts in Ixodes Scapularis (Acari: Ixodidae) in Connecticut, USA. 61
31971489 2020
19
Increased Incidence of Ehrlichia chaffeensis Infections in the United States, 2012 Through 2016. 61
32077809 2020
20
Genetic diversity of Anaplasma and Ehrlichia bacteria found in Dermacentor and Ixodes ticks in Mongolia. 61
31677968 2020
21
Ehrlichiosis Presenting as Hemophagocytic Lymphohistiocytosis in an Immunocompetent Adult. 61
32455115 2020
22
Discovery of in vivo Virulence Genes of Obligatory Intracellular Bacteria by Random Mutagenesis. 61
32117791 2020
23
Canine vector-borne disease in domestic dogs on Isla Santa Cruz, Galápagos. 61
32057400 2020
24
Determining Effects of Winter Weather Conditions on Adult Amblyomma americanum (Acari: Ixodidae) Survival in Connecticut and Maine, USA. 61
31877783 2019
25
Chemiluminescent ELISA with multi-epitope proteins to improve the diagnosis of canine visceral leishmaniasis. 61
31685139 2019
26
From Tick Bite to Heart Failure: Ehrlichial Myocarditis. 61
32159128 2019
27
Knowledge and prevention of tickborne diseases among Hispanic and non-Hispanic residents of Maryland and Virginia. 61
31478316 2019
28
Uncommon Ehrlichia canis infection associated with morulae in neutrophils from naturally infected dogs in Brazil. 61
31721463 2019
29
Isolation and Characterization of a Novel Pathogenic Strain of Ehrlichia minasensis. 61
31694172 2019
30
Human Case of Ehrlichia chaffeensis Infection, Taiwan. 61
31625863 2019
31
mTORC1-mediated polarization of M1 macrophages and their accumulation in the liver correlate with immunopathology in fatal ehrlichiosis. 61
31575880 2019
32
[Effectivity of diagnostic methods for the detection of human and canine monocytic ehrlichiosis]. 61
31859807 2019
33
Prevalence and risk factors associated with Ehrlichia infections in smallholder dairy cattle in Nairobi City County, Kenya. 61
31849422 2019
34
Predicted Northward Expansion of the Geographic Range of the Tick Vector Amblyomma americanum in North America under Future Climate Conditions. 61
31670575 2019
35
Atypical presentation of human ehrlichiosis and anaplasmosis in children in Israel. 61
31140643 2019
36
Detection of Rickettsiae, Borreliae, and Ehrlichiae in Ticks Collected from Walker County, Texas, 2017-2018. 61
31557808 2019
37
Acute acalculous cholecystitis as a manifestation of ehrlichiosis. 61
31155368 2019
38
Human ehrlichiosis at a tertiary-care academic medical center: Clinical associations and outcomes of transplant patients and patients with hemophagocytic lymphohistiocytosis. 61
30913447 2019
39
Ehrlichia Isolate from a Minnesota Tick: Characterization and Genetic Transformation. 61
31076433 2019
40
Conventional and Holter Electrocardiographic Assessment of Dogs Infected Naturally With Acute Canine Monocytic Ehrlichiosis. 61
31122685 2019
41
Performance of recombinant chimeric proteins in the serological diagnosis of Trypanosoma cruzi infection in dogs. 61
31242195 2019
42
Canine vector-borne disease: mapping and the accuracy of forecasting using big data from the veterinary community. 61
31895020 2019
43
Seroprevalence of Anaplasma phagocytophilum, Ehrlichia spp. and Borrelia burgdorferi infections in horses: first report from Northern Bulgaria - Short communication. 61
31238733 2019
44
Genetic diversity of Ehrlichia canis in dogs from Turkey inferred by TRP36 sequence analysis and phylogeny. 61
31174695 2019
45
TickPath Layerplex: adaptation of a real-time PCR methodology for the simultaneous detection and molecular surveillance of tick-borne pathogens. 61
31061487 2019
46
Molecular characterization of Anaplasma and Ehrlichia in ixodid ticks and reservoir hosts from Palestine: a pilot survey. 61
30762295 2019
47
First detection of Ehrlichia minasensis in Hyalomma marginatum ticks collected from cattle in Corsica, France. 61
30663864 2019
48
An update on the treatment of canine monocytic ehrlichiosis (Ehrlichia canis). 61
30902188 2019
49
Current Status of Tick-Borne Diseases in South Korea. 61
30328790 2019
50
Anti-Ehrlichia properties of the essential oil of Ageratum conyzoides L. and its interaction with doxycycline. 61
31037564 2019

Variations for Ehrlichiosis

Expression for Ehrlichiosis

Search GEO for disease gene expression data for Ehrlichiosis.

Pathways for Ehrlichiosis

Pathways related to Ehrlichiosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.7 TFRC ACO1

GO Terms for Ehrlichiosis

Biological processes related to Ehrlichiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte tethering or rolling GO:0050901 8.96 SELPLG SELP
2 positive regulation of leukocyte tethering or rolling GO:1903238 8.62 SELP FUT7

Sources for Ehrlichiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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