Aliases & Classifications for Elephantiasis

MalaCards integrated aliases for Elephantiasis:

Name: Elephantiasis 12 76 55 3 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4976
MeSH 44 D004604
NCIt 50 C34569
UMLS 73 C0013882

Summaries for Elephantiasis

CDC : 3 Lymphatic filariasis, considered globally as a neglected tropical disease, is a parasitic disease caused by microscopic, thread-like worms. The adult worms only live in the human lymph system. The lymph system maintains the body’s fluid balance and fights infections. Lymphatic filariasis is spread from person to person by mosquitoes.

MalaCards based summary : Elephantiasis is related to loiasis and erysipelas. An important gene associated with Elephantiasis is NF1 (Neurofibromin 1), and among its related pathways/superpathways is Cell adhesion_Cell-matrix glycoconjugates. The drugs Ivermectin and Praziquantel have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and liver.

Wikipedia : 76 Elephantiasis is gross enlargement of a limb or any organ of the body. There is an abnormal accumulation... more...

Related Diseases for Elephantiasis

Diseases related to Elephantiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 loiasis 31.5 MFF SRCIN1
2 erysipelas 30.7 ELANE ELN
3 filarial elephantiasis 12.5
4 podoconiosis 12.0
5 hydrocele 11.3
6 cerebral aneurysms 10.5 ELANE ELN
7 cerebral arterial disease 10.5 ELN NF1
8 mid-dermal elastolysis 10.5 ELANE ELN
9 alpha-1-antitrypsin deficiency 10.4 ELANE ELN
10 status asthmaticus 10.4 ELANE RNASE3
11 pulmonary emphysema 10.4 ELANE ELN
12 neurofibrosarcoma 10.4 INSRR NF1
13 adult respiratory distress syndrome 10.3 ELANE ELN
14 bronchopulmonary dysplasia 10.3 ELANE RNASE3
15 leukocyte disease 10.3 ELANE RNASE3
16 inguinal hernia 10.3 ELN NF1
17 lymphedema 10.3
18 bronchial disease 10.2 ELANE RNASE3
19 autoinflammation, lipodystrophy, and dermatosis syndrome 10.2 ELANE RNASE3
20 cellulitis 10.2 GJC2 RNASE3
21 autosomal genetic disease 10.2 ELANE NF1
22 filariasis 10.2
23 bronchitis 10.1 ELANE RNASE3
24 lymphangitis 10.1
25 sclerosing keratitis 10.1 MFF SRCIN1
26 deep keratitis 10.1 MFF SRCIN1
27 pulmonary disease, chronic obstructive 10.0 ELANE ELN RNASE3
28 anterior scleritis 10.0 MFF SRCIN1
29 respiratory system disease 10.0 ELANE RNASE3
30 aortic aneurysm, familial abdominal, 1 10.0 ELANE ELN
31 lymphadenitis 9.9
32 hidradenitis suppurativa 9.9
33 hidradenitis 9.9
34 lymphangiosarcoma 9.9
35 cystic fibrosis 9.9 ELANE ELN RNASE3
36 morbid obesity 9.9
37 onchocerciasis 9.9
38 neurofibroma 9.9
39 neurofibromatosis, type i 9.8
40 neurofibromatosis, type iv, of riccardi 9.8
41 venous insufficiency 9.8
42 sarcoma 9.8
43 graves' disease 9.8
44 lymphogranuloma venereum 9.8
45 thyroiditis 9.8
46 congenital lymphedema 9.8
47 wegener granulomatosis 9.7 ELANE ELN
48 kaposi sarcoma 9.6
49 lichen sclerosus et atrophicus 9.6
50 scleroderma, familial progressive 9.6

Graphical network of the top 20 diseases related to Elephantiasis:



Diseases related to Elephantiasis

Symptoms & Phenotypes for Elephantiasis

Drugs & Therapeutics for Elephantiasis

Drugs for Elephantiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 70288-86-7 6474909
2
Praziquantel Approved, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable 55268-74-1 4891
3
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
4
Albendazole Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 54965-21-8 2082
5
Azithromycin Approved Phase 4,Phase 2,Not Applicable 83905-01-5 55185 447043
6
Diethylcarbamazine Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 90-89-1 3052
7 Anthelmintics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
8 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
9 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
11 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
12 Lipoxygenase Inhibitors Phase 4,Phase 2,Phase 1,Not Applicable
13 Antimalarials Phase 4,Phase 3,Phase 2
14 Antimitotic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
15 Anticonvulsants Phase 4
16
Glycerol Approved, Investigational Phase 3 56-81-5 753
17
Petrolatum Approved, Investigational Phase 3 8009-03-8
18 Sodium hypochlorite Phase 3
19 Milbemycin Phase 3,Phase 2
20 Disinfectants Phase 3
21 Vitamins Phase 3
22 Eusol Phase 3
23 Protective Agents Phase 3
24
Rifampicin Approved Phase 2 13292-46-1 5458213 5381226
25
Dihydroartemisinin Approved, Investigational Phase 2 71939-50-9 6918483
26
Piperaquine Approved, Investigational Phase 2 4085-31-8 5079497
27 Respiratory System Agents Phase 2
28 Cytochrome P-450 CYP3A Inducers Phase 2
29 Nucleic Acid Synthesis Inhibitors Phase 2
30 Anti-Asthmatic Agents Phase 2
31 Antibiotics, Antitubercular Phase 2
32 Antibodies Phase 2
33 Immunoglobulins Phase 2
34 Antibodies, Monoclonal Phase 2
35 Antitubercular Agents Phase 2
36 Artemisinine Phase 2
37 Artemisinins Phase 2
38 Imatinib Mesylate Phase 2 220127-57-1 123596
39 Protein Kinase Inhibitors Phase 2
40
Romidepsin Approved, Investigational Phase 1 128517-07-7 5352062
41 Pharmaceutical Solutions Phase 1
42
Piperazine Approved, Vet_approved 110-85-0 4837
43
Mebendazole Approved, Vet_approved 31431-39-7 4030
44
Suramin Approved, Investigational 145-63-1 5361
45
Permethrin Approved, Investigational Not Applicable 52645-53-1 40326
46
Citric Acid Approved, Nutraceutical, Vet_approved 77-92-9 311
47 Piperazine citrate
48 Liver Extracts Not Applicable
49 Citrate Nutraceutical

Interventional clinical trials:

(show top 50) (show all 62)
# Name Status NCT ID Phase Drugs
1 Impact of Albendazole -Ivermectin on Wuchereria Bancrofti in Mali Completed NCT02784743 Phase 4 ''albendazole'' and ''ivermectin''
2 Post-treatment Effects of Ivermectin (IVM) or Diethylcarbamazine (DEC) in Loiasis Completed NCT01593722 Phase 4 Diethylcarbamazine;Ivermectin
3 Alternate Chemotherapy Regimens for the Clearance of W.Bancrofti Infection Completed NCT02005653 Phase 4 Diethylcarbamazine;Albendazole;Doxycycline
4 Twice Yearly Treatment for the Control of LF Recruiting NCT03036059 Phase 4 400 μg/kg Ivermectin + 400 mg Albendazole
5 Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH) Recruiting NCT03014167 Phase 4 Albendazole
6 Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy Recruiting NCT03052998 Phase 4 Ivermectin
7 Cluster RCT of Co-administration Azithromycin, Albendazole & Ivermectin Not yet recruiting NCT03570814 Phase 4 Administration of Albendazole on Day 1;Administration of Ivermectin on Day 1;Administration of Azithromycin on Day 1;Administration of Azithromycin on Day 15
8 Effect of Concomitant Mansonella Perstans Microfilaremia on Immune Responses Following Single Dose Praziquantel in People With Schistosomiasis Not yet recruiting NCT02734186 Phase 4 Praziquantel
9 Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis Withdrawn NCT01903057 Phase 4 azithromycin;ivermectin;albendazole;placebo
10 An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With Podoconiosis Completed NCT02839772 Phase 3
11 Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy Study Completed NCT02509481 Phase 2, Phase 3 Ivermectin;Albendazole
12 IVM Alone vs ALB + IVM Against Onchocerciasis Completed NCT03238131 Phase 3 Ivermectin;Albendazole
13 Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection Completed NCT00790998 Phase 3 Moxidectin;Ivermectin
14 A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali Recruiting NCT02927496 Phase 3 Doxycycline;Placebo
15 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka Recruiting NCT02929134 Phase 3 Doxycycline;Placebo
16 Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana Active, not recruiting NCT02078024 Phase 3 IVM plus ALB;IVM
17 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India Not yet recruiting NCT02929121 Phase 3 Doxycycline;Placebo
18 Effect of Albendazole Dose on Treatment of Lymphatic Filariasis Completed NCT00511004 Phase 2 Albendazole;Diethylcarbamazine
19 Doxycycline to Treat Mansonella Perstans Infection in Patients With and Without Lymphatic Filariasis Completed NCT00340691 Phase 2 Doxycycline
20 Effect of Albendazole Dose on Clearance of Filarial Worms Completed NCT00339417 Phase 2 Albendazole;Ivermectin
21 Effect of Albendazole Dose on Clearance of Filarial Worms Completed NCT00375583 Phase 2 DEC/Albendazole
22 Efficacy and Safety of High-dose Ivermectin for Reducing Malaria Transmission: A Dose Finding Study Completed NCT02511353 Phase 2 ivermectin;placebo;dihydroartemisinin-piperaquine
23 Reslizumab to Prevent Post-treatment Eosinophilia in Loiasis Completed NCT01111305 Phase 2 Reslizumab;Diethylcarbamazine
24 Study Evaluating Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection Completed NCT00300768 Phase 2 2 mg moxidectin;ivermectin 150 mcg/kg;4 mg moxidectin;8 mg moxidectin
25 Clinical Trial of Rifampin and Azithromycin for the Treatment of River Blindness Completed NCT00127504 Phase 2 Rifampin;Azithromycin
26 Concomitant Infections of Mansonella Perstans in Tuberculosis and Buruli Ulcer Disease Patients From Ghana Completed NCT02281643 Phase 2 Doxycycline
27 Eval 3-Drug Therapy Diethylcarbamize, Albendazole and Ivermectin That Could Accelerate LF Elimination Outside of Africa Active, not recruiting NCT01975441 Phase 2 Diethylcarbamazine;Albendazole;Ivermectin
28 Efficacy and Microfilaricidal Kinetics of Imatinib for the Treatment of Loa Loa Not yet recruiting NCT02644525 Phase 2 Imatinib Mesylate;Placebo
29 Pediatric Pharmacokinetics And Safety Study Of Moxidectin Withdrawn NCT01035619 Phase 2 moxidectin
30 Relative Bioavailability Study of Emodepside IR-tablets and Solution Completed NCT03383523 Phase 1 Emodepside (BAY 44-4400)
31 First in Man Clinical Trial of Emodepside (BAY 44-4400) Completed NCT02661178 Phase 1 emodepside (BAY 44-4400);placebo
32 Safety, Tolerability and PK of Multiple-ascending Doses of Emodepside Recruiting NCT03383614 Phase 1 LSF emodepside (BAY 44-4400) oral solution (1mg/mL)
33 Pharmacokinetics & Pharmacodynamics of Diethylcarbamazine (DEC)+ Albendazole (ALB) + Ivermectin (IVE) Active, not recruiting NCT02845713 Phase 1 Ivermectin, Diethylcarbamazine Albendazole (IDA)
34 Disability and Quality of Life in Patients With Lymphatic Filariasis in Rural Southern India Completed NCT01629771
35 Exhaled NO Testing in Filariasis Completed NCT01628497
36 Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis Completed NCT01905423 Albendazole and diethylcarbamazine
37 Research for Elim of Filariasis Completed NCT00145223
38 Research for Elimination of Lymphatic Filariasis (ICIDR) Completed NCT00406627
39 Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast) Completed NCT02032043 Annual versus Semiannual Albendazole plus Ivermectin MDA
40 Mass Drug Administration for Lymphatic Filariasis and Onchocerciasis for Liberia Completed NCT01905436 Annual versus Semiannual Albendazole plus Ivermectin Mass Drug Administration
41 Interaction Between HIV and Lymphatic Filariasis Completed NCT00295698 Not Applicable Diethylcarbamazine
42 Evaluation of Antibacterial Soap for Treatment of Lymphedema in a Filariasis-Endemic Area Completed NCT00139100 Not Applicable antimicrobial agent in soap
43 Medical Implications of Coinfection With Malaria and Filariasis Parasites Completed NCT00471666
44 Safety of the Co-administration of Three Drugs for Trachoma and Lymphatic Filariasis Elimination Completed NCT01586169 Not Applicable triple co administration at once of the combination of Albendazole + ivermectin + azithromycin
45 Changes in HIV Viral Load in Patients Undergoing Treatment for Filariasis Completed NCT00344279
46 Promoting Consistent Shoe Use Among Children At High Risk for Podoconiosis Completed NCT01160523
47 Immune Response Regulation in People Infected Concurrently With Malarial and Filarial Parasites Completed NCT00341666
48 Safety and Efficacy of Drug Combinations Against Triple Infections Completed NCT01050517 Not Applicable albendazole + ivermectin + praziquantel;albendazole + ivermectin + (1 week later) praziquantel
49 Community Directed Treatment of Soil-Transmitted Helminths Among Young Children in Zambia Completed NCT00349323
50 Study of Patients With Strongyloides Stercoralis Infection Completed NCT00001245

Search NIH Clinical Center for Elephantiasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: elephantiasis

Genetic Tests for Elephantiasis

Anatomical Context for Elephantiasis

MalaCards organs/tissues related to Elephantiasis:

41
Skin, Testes, Liver, Lymph Node, Thyroid, Bone, Cervix

Publications for Elephantiasis

Articles related to Elephantiasis:

(show top 50) (show all 445)
# Title Authors Year
1
Warty Fingers and Toes in a Child With Congenital Lymphedema: Elephantiasis Nostras Verrucosa. ( 29710245 )
2018
2
Unsuspected Amelanotic Melanoma in an Elephantiasis Foot. ( 29854646 )
2018
3
Bilateral vulval filarial elephantiasis. ( 29472427 )
2018
4
Treatment of elephantiasis of the leg by fasciotomy and lymphangiectomy with skin preservation in a resource-limited setting: a case report and review. ( 29616640 )
2018
5
Bilateral Lower Limb and Abdominal Elephantiasis Due to Erysipelas. ( 29578137 )
2018
6
Podoconiosis: Nonfilarial endemic elephantiasis. ( 29371058 )
2018
7
The Successful Treatment of Elephantiasis Nostras Verrucosa With Ablative Carbon Dioxide Laser. ( 29519146 )
2018
8
Giant elephantiasis and inguino-scrotal hernia. ( 28617809 )
2017
9
Wuchereria bancrofti infection at four primary schools and surrounding communities with no previous blood surveys in northern Uganda: the prevalence after mass drug administrations and a report on suspected non-filarial endemic elephantiasis. ( 28814926 )
2017
10
Beta Human Papillomavirus Infection Is Prevalent in Elephantiasis and Exhibits a Productive Phenotype: A Case-Control Study. ( 28253203 )
2017
11
A Case of Exuberant Elephantiasis Nostras Verrucosa. ( 28865510 )
2017
12
Elephantiasis nostras verrucosa. ( 29067989 )
2017
13
Elephantiasis nostras verrucosa secondary to recurrent erysipelas. ( 28838924 )
2017
14
Elephantiasis nostras verrucosa: a rare complication of lower limb lymphoedema. ( 28847994 )
2017
15
Elephantiasis nostras verrucosa secondary to congestive cardiac failure. ( 26944379 )
2016
16
Elephantiasis Nostras Verrucosa. Excision with full-thickness skin grafting of the penis, scrotum, and perineal area. ( 27900063 )
2016
17
Evolution of Skin during Rehabilitation for Elephantiasis Using Intensive Treatment. ( 27999691 )
2016
18
Giant elephantiasis neuromatosa in the setting of neurofibromatosis type 1: A case report. ( 27284375 )
2016
19
Abdominal Elephantiasis Nostras Verrucosa: An Underrecognized Disorder. ( 27784526 )
2016
20
Scroto-perineal hidradenitis suppurativa complicated by giant scrotal elephantiasis. ( 25837812 )
2015
21
Liposuction Normalizes Lymphedema Induced Adipose Tissue Hypertrophy in Elephantiasis of the Leg - A Prospective Study with a Ten-Year Follow-Up. ( 26397659 )
2015
22
Successful Surgical Treatment for Elephantiasis Nostras Verrucosa Using a New Designed Column Flap. ( 25573979 )
2015
23
The diagnostic challenge of mapping elephantiasis in the Tigray region of northern Ethiopia. ( 26518364 )
2015
24
Vulval elephantiasis. ( 26500880 )
2015
25
Elephantiasis nostras verrucosa occurring in voluntary shut-in ("hikikomori"). ( 25500212 )
2015
26
Resolution of septic shock in a patient with myelomeningocele (spina bifida) complicated with deforming Elephantiasis Nostras Verrucosa. ( 25623264 )
2015
27
A case of progressive elephantiasis nostras verrucosa. ( 25832960 )
2015
28
Scrotal elephantiasis secondary to recalcitrant hidradenitis suppurativa. ( 26087097 )
2015
29
Verrucous lesions arising in lymphedema and diabetic neuropathy: Elephantiasis nostras verrucosa or verrucous skin lesions on the feet of patients with diabetic neuropathy? ( 26281791 )
2015
30
Epidemiology of elephantiasis with special emphasis on podoconiosis in Ethiopia: A literature review. ( 26119541 )
2015
31
Massive Soft Tissue Neurofibroma (Elephantiasis Neuromatosa): Case Report and Review of Literature. ( 25694465 )
2015
32
NF1 truncating mutations associated to aggressive clinical phenotype with elephantiasis neuromatosa and solid malignancies. ( 24922668 )
2014
33
Elephantiasis nostras verrucosa. ( 24682133 )
2014
34
Debulking surgery for elephantiasis nostras with large ectatic podoplanin-negative lymphatic vessels in patients with lipo-lymphedema. ( 24741382 )
2014
35
Recurrent unilateral vulval elephantiasis: a case report. ( 24971141 )
2014
36
Elephantiasis nostras verrucosa as a manifestation of morbid obesity. ( 25406220 )
2014
37
Photoclinic. Elephantiasis nostras verrucosa secondary to lymphedema praecox. ( 24979570 )
2014
38
Elephantiasis nostras verrucosa of lower limb: a case report. ( 25369015 )
2014
39
Maggot Therapy for Elephantiasis Nostras Verrucosa Reveals New Applications and New Complications: A Case Report. ( 24861094 )
2014
40
How 'The association of endemic elephantiasis of the lower legs in East Africa with soil derived from volcanic rocks' has underpinned progress in podoconiosis research. ( 25059525 )
2014
41
Excision of Elephantiasis Nostras Verrucosa Lesions in a Patient With Hereditary Lymphedema: Case Report and Review of the Literature. ( 25441846 )
2014
42
Images in clinical medicine. Elephantiasis nostras verrucosa. ( 24963571 )
2014
43
Elephantiasis nostras verrucosa. ( 24856044 )
2014
44
Modelling environmental factors correlated with podoconiosis: a geospatial study of non-filarial elephantiasis. ( 24946801 )
2014
45
A surgical challenge: Idiopathic scrotal elephantiasis. ( 25132898 )
2014
46
Penile elephantiasis: a rare consequence of inappropriate use of condom as external urinary collection receptacle. ( 23355598 )
2013
47
Giant penile elephantiasis after circumcision: a devastating complication. ( 24042209 )
2013
48
Elephantiasis nostras verrucosa in a patient with obesity and chronic venous insufficiency. ( 23432135 )
2013
49
What is your diagnosis? Elephantiasis nostras verrucosa of the back. ( 23513550 )
2013
50
Obesity-associated abdominal elephantiasis. ( 23606857 )
2013

Variations for Elephantiasis

Expression for Elephantiasis

Search GEO for disease gene expression data for Elephantiasis.

Pathways for Elephantiasis

Pathways related to Elephantiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.21 ELANE ELN

GO Terms for Elephantiasis

Cellular components related to Elephantiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 azurophil granule lumen GO:0035578 8.96 ELANE RNASE3
2 axon GO:0030424 8.8 INSRR NF1 SRCIN1

Biological processes related to Elephantiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 9.26 ELANE ELN
2 antimicrobial humoral response GO:0019730 9.16 ELANE RNASE3
3 skeletal muscle tissue development GO:0007519 8.96 ELN NF1
4 cell communication GO:0007154 8.62 GJC2 NF1

Sources for Elephantiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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