MCID: EMB002
MIFTS: 46

Embryoma

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Embryoma

MalaCards integrated aliases for Embryoma:

Name: Embryoma 12 15
Blastoma 12 76 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4766
NCIt 50 C8997
SNOMED-CT 68 86049000
UMLS 73 C0936282

Summaries for Embryoma

Disease Ontology : 12 A carcinosarcoma and embryonal cancer that is located in embryonic tissue and results in a mass of rapidly growing cells.

MalaCards based summary : Embryoma, also known as blastoma, is related to mixed germ cell tumor and endodermal sinus tumor. An important gene associated with Embryoma is SALL4 (Spalt Like Transcription Factor 4), and among its related pathways/superpathways are Developmental Biology and Wnt / Hedgehog / Notch. The drugs Avastin and Gliadel Wafer have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and testis, and related phenotypes are cellular and endocrine/exocrine gland

Wikipedia : 76 A blastoma is a type of cancer, more common in children, that is caused by malignancies in precursor... more...

Related Diseases for Embryoma

Diseases related to Embryoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
# Related Disease Score Top Affiliating Genes
1 mixed germ cell tumor 30.1 AFP KIT
2 endodermal sinus tumor 29.9 AFP GPC3 SALL4
3 embryonal sarcoma 29.8 GPC3 KIT
4 teratoma 29.7 AFP CDX2 KIT POU5F1
5 pleuropulmonary blastoma 12.7
6 dicer1-related pleuropulmonary blastoma cancer predisposition syndrome 12.5
7 classic pulmonary blastoma 12.2
8 pleuropulmonary blastoma type 1 12.1
9 epithelial predominant pulmonary blastoma 12.0
10 pleuropulmonary blastoma type 2 12.0
11 pleuropulmonary blastoma type 3 12.0
12 dicer1-related disorders 11.6
13 wilms tumor 6 11.5
14 cystic nephroma 10.3
15 pneumothorax 10.3
16 carcinosarcoma 10.3
17 cystic adenomatoid malformation of lung 10.2
18 ovarian germ cell cancer 10.2 AFP SALL4
19 medulloepithelioma 10.2
20 testicular malignant germ cell cancer 10.2 AFP GPC3
21 gastric signet ring cell adenocarcinoma 10.2 CDX2 GATA3
22 hepatic adenomas, familial 10.2 AFP GPC3
23 predominantly cortical thymoma 10.2 KRT14 KRT19
24 horseshoe kidney 10.2 CDX2 HNF1B
25 hepatoid adenocarcinoma 10.2 AFP CDX2
26 seminal vesicle tumor 10.2 AFP GPC3
27 pulmonary blastoma 10.1
28 brain germinoma 10.1 AFP POU5F1
29 anus adenocarcinoma 10.1 CDX2 KRT19
30 extragonadal germ cell cancer 10.1 AFP POU5F1
31 central nervous system germ cell tumor 10.1 AFP POU5F1
32 embryonal testis carcinoma 10.1 AFP POU5F1
33 cervical clear cell adenocarcinoma 10.1 KRT14 KRT19
34 tumor predisposition syndrome 10.1
35 odontoma 10.1 KRT14 KRT19
36 pseudopapilledema 10.1 GATA3 IGF2
37 spermatocytoma 10.1 KIT SALL4
38 anal canal adenocarcinoma 10.1 CDX2 KRT19
39 mature teratoma 10.1 AFP POU5F1
40 limbal stem cell deficiency 10.1 KRT14 KRT19
41 lipoadenoma 10.1 KRT14 KRT19
42 biliary papillomatosis 10.1 CDX2 KRT19
43 pineoblastoma 10.1 AFP POU5F1
44 superior mesenteric artery syndrome 10.1 CDX2 KRT19
45 intrahepatic bile duct adenoma 10.1 AFP KRT19
46 cystitis cystica 10.1 CDX2 GATA3
47 pregnancy adenoma 10.1 KRT14 KRT19
48 helsmoortel-van der aa syndrome 10.1 KIT SALL4
49 renal pelvis adenocarcinoma 10.1 AFP KRT19
50 mixed germ cell cancer 10.1 AFP POU5F1

Graphical network of the top 20 diseases related to Embryoma:



Diseases related to Embryoma

Symptoms & Phenotypes for Embryoma

MGI Mouse Phenotypes related to Embryoma:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.21 CDX2 GATA3 GPC3 IGF2 KIT KRT14
2 endocrine/exocrine gland MP:0005379 10.21 AFP CDX2 GATA3 HNF1B IGF2 KIT
3 digestive/alimentary MP:0005381 10.19 CDX2 GATA3 GPC3 IGF2 KIT KRT14
4 embryo MP:0005380 10.18 CDX2 GATA3 GPC3 HNF1B IGF2 KIT
5 growth/size/body region MP:0005378 10.15 CDX2 GATA3 GPC3 HNF1B IGF2 KIT
6 homeostasis/metabolism MP:0005376 10.13 AFP CDX2 GATA3 GPC3 HNF1B IGF2
7 cardiovascular system MP:0005385 10.11 CDX2 GATA3 GPC3 IGF2 KIT KRT19
8 mortality/aging MP:0010768 10.11 AFP CDX2 GATA3 GPC3 HNF1B IGF2
9 immune system MP:0005387 10.06 GATA3 GPC3 HNF1B IGF2 KIT KRT14
10 craniofacial MP:0005382 10.02 GATA3 GPC3 IGF2 KIT KRT14 SALL4
11 integument MP:0010771 9.98 GATA3 GPC3 IGF2 KIT KRT14 KRT19
12 limbs/digits/tail MP:0005371 9.8 CDX2 GPC3 IGF2 KIT SALL4
13 neoplasm MP:0002006 9.72 AFP CDX2 KIT KRT14 KRT19
14 reproductive system MP:0005389 9.65 AFP CDX2 GATA3 GPC3 IGF2 KIT
15 renal/urinary system MP:0005367 9.63 GATA3 GPC3 HNF1B IGF2 KIT SALL4
16 pigmentation MP:0001186 9.56 GATA3 GPC3 KIT KRT14
17 skeleton MP:0005390 9.17 CDX2 GATA3 GPC3 IGF2 KIT KRT19

Drugs & Therapeutics for Embryoma

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Avastin 18 49 BEVACIZUMAB Genentech July 2009
2
Gliadel Wafer 18 49 CARMUSTINE Rhone-Poulenc Rorer, Guilford Pharmaceuticals February 1997
3
Ibrance 18 49 PALBOCICLIB Pfizer February 2015
4
Temodar 18 49 TEMOZOLOMIDE Schering-Plough August 1999
5
Unituxin 18 49 DINUTUXIMAB United Therapeutics March 2015

Drugs for Embryoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
2
Trastuzumab Approved, Investigational Phase 2 180288-69-1 9903
3
Adenosine Approved, Investigational Phase 2 58-61-7 60961
4 Alkylating Agents Phase 2,Not Applicable
5 Antineoplastic Agents, Alkylating Phase 2,Not Applicable
6 Antineoplastic Agents, Phytogenic Phase 2,Not Applicable
7 Antimitotic Agents Phase 2,Not Applicable
8 Antibodies Phase 2
9 Maytansine Phase 2
10 Ado-trastuzumab emtansine Phase 2
11 Immunoglobulins Phase 2
12 Antibodies, Monoclonal Phase 2
13
Dactinomycin Approved, Investigational Not Applicable 50-76-0 457193 2019
14
Doxorubicin Approved, Investigational Not Applicable 23214-92-8 31703
15
Vincristine Approved, Investigational Not Applicable 57-22-7, 2068-78-2 5978
16
Cyclophosphamide Approved, Investigational Not Applicable 6055-19-2, 50-18-0 2907
17
Mechlorethamine Approved, Investigational Not Applicable 51-75-2 4033
18
Ifosfamide Approved Not Applicable 3778-73-2 3690
19
Doxil Approved June 1999 Not Applicable 31703
20 Immunologic Factors Not Applicable
21
Isophosphamide mustard Not Applicable 0
22 Anti-Infective Agents Not Applicable
23 Antirheumatic Agents Not Applicable
24 Antibiotics, Antitubercular Not Applicable
25 Nucleic Acid Synthesis Inhibitors Not Applicable
26 Anti-Bacterial Agents Not Applicable
27 Immunosuppressive Agents Not Applicable
28 Topoisomerase Inhibitors Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Hyperbaric Hyperoxygenation With Radiotherapy and Temozolomide in Adults With Newly Diagnosed Glioblastoma Unknown status NCT00936052 Phase 2
2 Lorvotuzumab Mertansine in Treating Younger Patients With Relapsed or Refractory Wilms Tumor, Rhabdomyosarcoma, Neuroblastoma, Pleuropulmonary Blastoma, Malignant Peripheral Nerve Sheath Tumor, or Synovial Sarcoma Active, not recruiting NCT02452554 Phase 2
3 Gene Mutation in Samples From Young Patients With Pleuropulmonary Blastoma Syndrome at Risk for Developing Cancer Completed NCT01353300
4 Review of the Paediatric Pleuropulmonary Blastoma French Series Recruiting NCT03044834
5 International Pleuropulmonary Blastoma (PPB) Treatment and Biology Registry Recruiting NCT01464606 Not Applicable Vincristine;Dactinomycin;Cyclophosphamide;Ifosfamide;Doxorubicin
6 Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome Recruiting NCT00565903
7 DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study Recruiting NCT01247597
8 International PPB Registry for PPB, DICER1 and Associated Conditions Recruiting NCT03382158
9 International Ovarian & Testicular Stromal Tumor Registry Recruiting NCT01970696
10 Congenital Lung Anomalies (CLA) Swiss Database Recruiting NCT03044769

Search NIH Clinical Center for Embryoma

Genetic Tests for Embryoma

Anatomical Context for Embryoma

MalaCards organs/tissues related to Embryoma:

41
Kidney, Lung, Testis, Thyroid, Liver, Small Intestine, Fetal Lung

The Foundational Model of Anatomy Ontology organs/tissues related to Embryoma:

19
Embryonic Tissue

Publications for Embryoma

Articles related to Embryoma:

(show top 50) (show all 71)
# Title Authors Year
1
Wilms tumor, pleuropulmonary blastoma, and DICER1: case report and literature review. ( 30097050 )
2018
2
Pleuropulmonary Blastoma Developing in a Case of Misinterpreted Congenital Pulmonary Airway Malformation: a Case Report. ( 30358469 )
2018
3
Pulmonary Blastoma in an Adult Presenting with Hemoptysis and Hemothorax. ( 30365956 )
2018
4
Metachronous Type I pleuropulmonary blastoma and atypical choroid plexus papilloma in a young child. ( 27442759 )
2016
5
Infant pleuropulmonary blastoma: report of a rare case and review of literature. ( 26722577 )
2015
6
Temporal order of RNase IIIb and loss-of-function mutations during development determines phenotype in DICER1 syndrome: a unique variant of the two-hit tumor suppression model. ( 26925222 )
2015
7
Thoracoscopic lobectomy for type I pleuropulmonary blastoma in an infant. ( 23588846 )
2014
8
Pleuropulmonary blastoma in children: a case report. ( 25628828 )
2012
9
Radical resection of pleuropulmonary blastoma. ( 27755807 )
2011
10
Pneumothorax and pulmonary cyst in a 2-year-old child. Pleuropulmonary blastoma. ( 16594758 )
2006
11
Solitary brain metastasis from classic biphasic pulmonary blastoma: a case report and review of the literature. ( 17202827 )
2006
12
Congenital sialoblastoma (embryoma) associated with premature centromere division and high level of alpha-fetoprotein. ( 16049999 )
2005
13
Diffuse embryoma with intratubular germ-cell neoplasia. ( 15469489 )
2004
14
Pleuropulmonary blastoma: management and prognosis of 11 cases. ( 11002236 )
2000
15
Role of radiotherapy in conjunction with chemotherapy in giant pleuropulmonary blastoma. ( 9707868 )
1998
16
Sialoblastoma (embryoma): MR findings of a rare pediatric salivary gland tumor. ( 9159361 )
1997
17
Pleuropulmonary blastoma with vascular invasion. ( 8553935 )
1996
18
Diffuse embryoma of the testis. ( 7726152 )
1995
19
Pleuro-pulmonary blastoma: a case report and review of the literature. ( 7565313 )
1995
20
Diffuse embryoma of the testis. An immunohistochemical study of two cases. ( 7524298 )
1994
21
Embryoma (sialoblastoma) of salivary glands. ( 1444105 )
1992
22
Childhood pulmonary blastoma: a pleuropulmonary variant of the adult-type pulmonary blastoma. ( 1720893 )
1991
23
Pulmonary blastoma--report of a case. ( 2848950 )
1988
24
Pulmonary blastoma in childhood. ( 3807382 )
1987
25
Embryoma (or embryonal tumor) of the parotid gland: report of two cases. ( 3725707 )
1986
26
Laryngeal blastoma. A light and electron microscopic study of a novel entity analogous to pulmonary blastoma. ( 2994458 )
1985
27
Diffuse embryoma of the testis. A distinctive form of mixed germ cell tumor. ( 6195930 )
1983
28
Pulmonary blastoma: case report and literature review. ( 998819 )
1976
29
Pulmonary blastoma (embryoma lung). A case report with review of literature. ( 1193668 )
1975
30
Pulmonary blastoma. ( 4355012 )
1973
31
Renal embryoma in an adult. ( 4339834 )
1972
32
Roentgen manifestations of pulmonary blastoma. ( 5041154 )
1972
33
Metastatic renal embryoma: survival following therapy. ( 4293670 )
1967
34
Pulmonary blastoma (embryoma). Report of two cases. ( 5931363 )
1966
35
Pulmonary blastoma, a form of carcinosarcoma. Report of a case of 24 years' duration without treatment. ( 4288403 )
1966
36
EMBRYOMA OF KIDNEY IN NEWBORN INFANT: CASE REPORT. ( 14276199 )
1965
37
Radiologic seminar XV: Embryoma of the kidney (Wilm's tumor). ( 13952914 )
1963
38
Primary hepatic malignancy with particular reference to the embryoma of infancy. ( 14492775 )
1961
39
Malignant embryoma of the neural crest. ( 13746972 )
1960
40
Treatment of pulmonary metastases from malignant embryoma of the testicle with nitrofurazone ( 13820432 )
1960
41
Embryoma of the kidney (Wilms' tumor). ( 14403711 )
1960
42
Malignant melanoma or retino-blastoma in an adult. ( 13816282 )
1960
43
Renal embryoma. ( 13601962 )
1958
44
Polyembryonic embryoma of the ovary of parthenogenetic origin. ( 13426978 )
1957
45
Embryoma of the urinary bladder. ( 13368293 )
1956
46
Embryoma of the kidney; case report of a fourteen-year cure. ( 13334846 )
1956
47
Bilateral embryoma of the kidney; patient alive and well three years after treatment. ( 13336329 )
1956
48
Embryoma of the urinary bladder. ( 13359346 )
1955
49
Embryoma of lungs. ( 13015519 )
1952
50
Adrenogenital syndrome in a male child due to adrenocortical tumor; report of case with hemihypertrophy and subsequent development of embryoma (Wilms' tumor). ( 12983105 )
1952

Variations for Embryoma

Expression for Embryoma

Search GEO for disease gene expression data for Embryoma.

Pathways for Embryoma

GO Terms for Embryoma

Biological processes related to Embryoma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.97 GATA3 HNF1B IGF2 POU5F1 SALL4
2 positive regulation of gene expression GO:0010628 9.8 GATA3 HNF1B KIT POU5F1
3 cellular protein metabolic process GO:0044267 9.75 AFP GPC3 IGF2
4 in utero embryonic development GO:0001701 9.73 GATA3 IGF2 SALL4
5 positive regulation of protein kinase B signaling GO:0051897 9.71 GATA3 IGF2 KIT
6 anatomical structure morphogenesis GO:0009653 9.63 GATA3 GPC3 POU5F1
7 negative regulation of transcription by RNA polymerase II GO:0000122 9.63 CDX2 GATA3 HNF1B IGF2 POU5F1 SALL4
8 kidney development GO:0001822 9.61 GATA3 GPC3 HNF1B
9 T cell differentiation GO:0030217 9.58 GATA3 KIT
10 ventricular septum development GO:0003281 9.55 GATA3 SALL4
11 tissue development GO:0009888 9.52 GATA3 SALL4
12 blastocyst development GO:0001824 9.51 CDX2 POU5F1
13 embryonic hemopoiesis GO:0035162 9.48 GATA3 KIT
14 epithelial cell proliferation GO:0050673 9.4 HNF1B KIT
15 endodermal cell fate specification GO:0001714 9.37 HNF1B POU5F1
16 mast cell differentiation GO:0060374 9.32 GATA3 KIT
17 nephric duct formation GO:0072179 9.26 GATA3 HNF1B
18 animal organ morphogenesis GO:0009887 9.26 CDX2 GATA3 GPC3 IGF2
19 somatic stem cell population maintenance GO:0035019 8.92 CDX2 KIT POU5F1 SALL4

Molecular functions related to Embryoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proximal promoter sequence-specific DNA binding GO:0000987 8.96 GATA3 HNF1B
2 enhancer sequence-specific DNA binding GO:0001158 8.62 GATA3 POU5F1

Sources for Embryoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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