MCID: EMB002
MIFTS: 32

Embryoma

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Embryoma

MalaCards integrated aliases for Embryoma:

Name: Embryoma 12 15
Blastoma 12 76 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4766
NCIt 50 C8997
SNOMED-CT 68 86049000
UMLS 73 C0936282

Summaries for Embryoma

Disease Ontology : 12 A carcinosarcoma and embryonal cancer that is located in embryonic tissue and results in a mass of rapidly growing cells.

MalaCards based summary : Embryoma, also known as blastoma, is related to pulmonary blastoma and pleuropulmonary blastoma. An important gene associated with Embryoma is DICER1 (Dicer 1, Ribonuclease III). The drugs Temozolomide and Trastuzumab have been mentioned in the context of this disorder. Affiliated tissues include embryonic tissue, kidney and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 A blastoma is a type of cancer, more common in children, that is caused by malignancies in precursor... more...

Related Diseases for Embryoma

Diseases related to Embryoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 pulmonary blastoma 31.0 DICER1 NKX2-1 SYP
2 pleuropulmonary blastoma 12.6
3 central nervous system primitive neuroectodermal neoplasm 10.3 DICER1 SYP
4 pineal gland cancer 10.3 DICER1 SYP
5 wilms tumor 5 10.3
6 wilms tumor 6 10.3
7 pineoblastoma 10.3 DICER1 SYP
8 sex cord-gonadal stromal tumor 10.2 DICER1 SYP
9 premature centromere division 9.8
10 hepatitis 9.8
11 thrombosis 9.8
12 sarcoma 9.8
13 ureterolithiasis 9.8
14 thyroiditis 9.8
15 germ cells tumors 9.8
16 mixed germ cell tumor 9.8
17 multinodular goiter 9.8 DICER1 NKX2-1
18 small cell carcinoma of the bladder 9.8 NKX2-1 SYP
19 ovarian germ cell cancer 9.8 NKX2-1 SALL4
20 pulmonary sclerosing hemangioma 9.8 NKX2-1 SYP
21 respiratory system benign neoplasm 9.8 NKX2-1 SYP
22 carcinoid tumors, intestinal 9.7 NKX2-1 SYP
23 extraskeletal ewing sarcoma 9.7 NKX2-1 SYP
24 sclerosing hemangioma 9.7 NKX2-1 SYP
25 cystic teratoma 9.7 NKX2-1 SYP
26 horseshoe kidney 9.7 NKX2-1 SYP
27 large cell neuroendocrine carcinoma 9.7 NKX2-1 SYP
28 lung benign neoplasm 9.6 NKX2-1 SYP
29 small cell carcinoma 9.6 NKX2-1 SYP
30 differentiated thyroid carcinoma 9.6 DICER1 NKX2-1
31 large cell carcinoma 9.6 NKX2-1 SYP
32 merkel cell carcinoma 9.6 NKX2-1 SYP
33 goiter 9.5 DICER1 NKX2-1
34 thymus cancer 9.5 NKX2-1 SYP
35 teratoma 9.5 NKX2-1 SYP
36 atypical choroid plexus papilloma 9.3 DICER1 NKX2-1 SYP
37 cell type cancer 9.2 NKX2-1 SYP
38 malignant teratoma 9.2 NKX2-1 SALL4 SYP
39 neuroendocrine tumor 9.0 NKX2-1 SYP

Graphical network of the top 20 diseases related to Embryoma:



Diseases related to Embryoma

Symptoms & Phenotypes for Embryoma

GenomeRNAi Phenotypes related to Embryoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.36 DICER1 KMT2C
2 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.36 DICER1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.36 KMT2C
4 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.36 DICER1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.36 KMT2C
6 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.36 DICER1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.36 KMT2C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.36 DICER1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.36 DICER1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.36 KMT2C

MGI Mouse Phenotypes related to Embryoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.02 DICER1 KMT2C LARGE1 NKX2-1 SALL4

Drugs & Therapeutics for Embryoma

Drugs for Embryoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
2
Trastuzumab Approved, Investigational Phase 2 180288-69-1 9903
3
Adenosine Approved, Investigational Phase 2 58-61-7 60961
4 Alkylating Agents Phase 2,Not Applicable
5 Antineoplastic Agents, Alkylating Phase 2,Not Applicable
6 Antimitotic Agents Phase 2,Not Applicable
7 Antineoplastic Agents, Phytogenic Phase 2,Not Applicable
8 Ado-trastuzumab emtansine Phase 2
9 Antibodies Phase 2
10 Immunoglobulins Phase 2
11 Antibodies, Monoclonal Phase 2
12 Maytansine Phase 2
13
Doxorubicin Approved, Investigational Not Applicable 23214-92-8 31703
14
Mechlorethamine Approved, Investigational Not Applicable 51-75-2 4033
15
Ifosfamide Approved Not Applicable 3778-73-2 3690
16
Vincristine Approved, Investigational Not Applicable 2068-78-2, 57-22-7 5978
17
Cyclophosphamide Approved, Investigational Not Applicable 50-18-0, 6055-19-2 2907
18
Dactinomycin Approved, Investigational Not Applicable 50-76-0 2019 457193
19
Doxil Approved June 1999 Not Applicable 31703
20
Isophosphamide mustard Not Applicable 0
21 Topoisomerase Inhibitors Not Applicable
22 Nucleic Acid Synthesis Inhibitors Not Applicable
23 Anti-Bacterial Agents Not Applicable
24 Antibiotics, Antitubercular Not Applicable
25 Immunosuppressive Agents Not Applicable
26 Anti-Infective Agents Not Applicable
27 Antirheumatic Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Hyperbaric Hyperoxygenation With Radiotherapy and Temozolomide in Adults With Newly Diagnosed Glioblastoma Unknown status NCT00936052 Phase 2
2 Lorvotuzumab Mertansine in Treating Younger Patients With Relapsed or Refractory Wilms Tumor, Rhabdomyosarcoma, Neuroblastoma, Pleuropulmonary Blastoma, Malignant Peripheral Nerve Sheath Tumor, or Synovial Sarcoma Active, not recruiting NCT02452554 Phase 2
3 Gene Mutation in Samples From Young Patients With Pleuropulmonary Blastoma Syndrome at Risk for Developing Cancer Completed NCT01353300
4 Review of the Paediatric Pleuropulmonary Blastoma French Series Recruiting NCT03044834
5 International Pleuropulmonary Blastoma (PPB) Treatment and Biology Registry Recruiting NCT01464606 Not Applicable Vincristine;Dactinomycin;Cyclophosphamide;Ifosfamide;Doxorubicin
6 Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome Recruiting NCT00565903
7 DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study Recruiting NCT01247597
8 International PPB Registry for PPB, DICER1 and Associated Conditions Recruiting NCT03382158
9 International Ovarian & Testicular Stromal Tumor Registry Recruiting NCT01970696
10 Congenital Lung Anomalies (CLA) Swiss Database Recruiting NCT03044769

Search NIH Clinical Center for Embryoma

Genetic Tests for Embryoma

Anatomical Context for Embryoma

The Foundational Model of Anatomy Ontology organs/tissues related to Embryoma:

19
Embryonic Tissue

MalaCards organs/tissues related to Embryoma:

41
Kidney, Lung, Testis, Ovary, Salivary Gland, Thyroid

Publications for Embryoma

Articles related to Embryoma:

(show all 46)
# Title Authors Year
1
Congenital sialoblastoma (embryoma) associated with premature centromere division and high level of alpha-fetoprotein. ( 16049999 )
2005
2
Diffuse embryoma with intratubular germ-cell neoplasia. ( 15469489 )
2004
3
Sialoblastoma (embryoma): MR findings of a rare pediatric salivary gland tumor. ( 9159361 )
1997
4
Diffuse embryoma of the testis. ( 7726152 )
1995
5
Diffuse embryoma of the testis. An immunohistochemical study of two cases. ( 7524298 )
1994
6
Embryoma (sialoblastoma) of salivary glands. ( 1444105 )
1992
7
Embryoma (or embryonal tumor) of the parotid gland: report of two cases. ( 3725707 )
1986
8
Diffuse embryoma of the testis. A distinctive form of mixed germ cell tumor. ( 6195930 )
1983
9
Pulmonary blastoma (embryoma lung). A case report with review of literature. ( 1193668 )
1975
10
Renal embryoma in an adult. ( 4339834 )
1972
11
Metastatic renal embryoma: survival following therapy. ( 4293670 )
1967
12
Pulmonary blastoma (embryoma). Report of two cases. ( 5931363 )
1966
13
EMBRYOMA OF KIDNEY IN NEWBORN INFANT: CASE REPORT. ( 14276199 )
1965
14
Radiologic seminar XV: Embryoma of the kidney (Wilm's tumor). ( 13952914 )
1963
15
Primary hepatic malignancy with particular reference to the embryoma of infancy. ( 14492775 )
1961
16
Malignant embryoma of the neural crest. ( 13746972 )
1960
17
Treatment of pulmonary metastases from malignant embryoma of the testicle with nitrofurazone ( 13820432 )
1960
18
Embryoma of the kidney (Wilms' tumor). ( 14403711 )
1960
19
Renal embryoma. ( 13601962 )
1958
20
Polyembryonic embryoma of the ovary of parthenogenetic origin. ( 13426978 )
1957
21
Embryoma of the urinary bladder. ( 13368293 )
1956
22
Embryoma of the kidney; case report of a fourteen-year cure. ( 13334846 )
1956
23
Bilateral embryoma of the kidney; patient alive and well three years after treatment. ( 13336329 )
1956
24
Embryoma of the urinary bladder. ( 13359346 )
1955
25
Embryoma of lungs. ( 13015519 )
1952
26
Adrenogenital syndrome in a male child due to adrenocortical tumor; report of case with hemihypertrophy and subsequent development of embryoma (Wilms' tumor). ( 12983105 )
1952
27
Embryoma of the kidney (Wilms' tumor); a report on two recoveries. ( 14864825 )
1951
28
The effect of preoperative roentgen-ray therapy on arterial hypertension in embryoma (kidney). ( 15395003 )
1949
29
Embryoma of the kidney with symptoms at birth. ( 15409288 )
1949
30
Embryoma of contralateral kidney 10 years following nephrectomy for Wilms' tumor. ( 18130185 )
1949
31
Embryoma of kidney (Wilms' tumor) in children. ( 18137842 )
1949
32
Hypertension in embryoma; Wilms' tumor. ( 18111427 )
1949
33
Embryoma of the testicle in a 5-year old child. ( 18872800 )
1948
34
Wilms' tumor (embryoma of the kidney). ( 18896881 )
1947
35
Embryoma of the kidney in the adult. ( 20995867 )
1946
36
Embryoma of the kidney (Wilms' tumor). ( 20987926 )
1946
37
Wilms' embryoma: A Clinico-Pathological Study. ( 21032107 )
1938
38
EMBRYOMA OF THE KIDNEY (WILMS' TUMOR). ( 17857280 )
1938
39
Wilms' Tumour, or Renal Embryoma of Infancy. ( 19989690 )
1934
40
Simple Ovarian Embryoma with Spread into Contiguous Structures. ( 19984494 )
1925
41
EMBRYOMA IN THE OMENTUM CAUSING SYMPTOMS SUGGESTIVE OF URETERAL CALCULUS. ( 20771984 )
1925
42
EMBRYOMA OF THE TESTIS: Sudden Death from Thrombosis of Pulmonary Veins. ( 20772247 )
1925
43
SARCOMA OR EMBRYOMA OF THE KIDNEY IN INFANTS. ( 17864795 )
1923
44
EMBRYOMA OF THE KIDNEY. ( 17864886 )
1923
45
Cystic Embryoma of Ovary. ( 19981163 )
1920
46
Thyroid Tissue in an Ovarian Embryoma. ( 19975290 )
1911

Variations for Embryoma

Expression for Embryoma

Search GEO for disease gene expression data for Embryoma.

Pathways for Embryoma

GO Terms for Embryoma

Sources for Embryoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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