MCID: EMB002
MIFTS: 45

Embryoma

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Embryoma

MalaCards integrated aliases for Embryoma:

Name: Embryoma 12 15
Blastoma 12 77 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4766
NCIt 51 C8997
SNOMED-CT 69 86049000
UMLS 74 C0936282

Summaries for Embryoma

Disease Ontology : 12 A carcinosarcoma and embryonal cancer that is located in embryonic tissue and results in a mass of rapidly growing cells.

MalaCards based summary : Embryoma, also known as blastoma, is related to mixed germ cell tumor and embryonal sarcoma. An important gene associated with Embryoma is SALL4 (Spalt Like Transcription Factor 4), and among its related pathways/superpathways are Developmental Biology and Wnt / Hedgehog / Notch. The drugs Temozolomide and Trastuzumab have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and testis, and related phenotypes are cellular and endocrine/exocrine gland

Wikipedia : 77 A blastoma is a type of cancer, more common in children, that is caused by malignancies in precursor... more...

Related Diseases for Embryoma

Diseases related to Embryoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 mixed germ cell tumor 30.1 AFP KIT
2 embryonal sarcoma 29.9 GPC3 KIT
3 teratoma 29.4 AFP CDX2 KIT POU5F1
4 pleuropulmonary blastoma 12.8
5 dicer1-related pleuropulmonary blastoma cancer predisposition syndrome 12.5
6 classic pulmonary blastoma 12.2
7 pleuropulmonary blastoma type 1 12.1
8 epithelial predominant pulmonary blastoma 12.1
9 pleuropulmonary blastoma type 2 12.0
10 pleuropulmonary blastoma type 3 12.0
11 dicer1-related disorders 11.7
12 wilms tumor 5 11.5
13 wilms tumor 6 10.5
14 cystic nephroma 10.4
15 pneumothorax 10.3
16 carcinosarcoma 10.3
17 cystic adenomatoid malformation of lung 10.2
18 ovarian germ cell cancer 10.2 AFP SALL4
19 horseshoe kidney 10.2 CDX2 HNF1B
20 gastric signet ring cell adenocarcinoma 10.2 CDX2 GATA3
21 predominantly cortical thymoma 10.2 KRT14 KRT19
22 testicular malignant germ cell cancer 10.2 AFP GPC3
23 medulloepithelioma 10.2
24 anus adenocarcinoma 10.2 CDX2 KRT19
25 hepatic adenomas, familial 10.2 AFP GPC3
26 cervical clear cell adenocarcinoma 10.2 KRT14 KRT19
27 odontoma 10.2 KRT14 KRT19
28 seminal vesicle tumor 10.2 AFP GPC3
29 hepatoid adenocarcinoma 10.2 AFP CDX2
30 spermatocytoma 10.2 KIT SALL4
31 limbal stem cell deficiency 10.2 KRT14 KRT19
32 anal canal adenocarcinoma 10.2 CDX2 KRT19
33 lipoadenoma 10.2 KRT14 KRT19
34 pulmonary blastoma 10.2
35 tumor predisposition syndrome 10.2
36 brain germinoma 10.2 AFP POU5F1
37 biliary papillomatosis 10.2 CDX2 KRT19
38 helsmoortel-van der aa syndrome 10.2 KIT SALL4
39 cystitis cystica 10.2 CDX2 GATA3
40 pregnancy adenoma 10.2 KRT14 KRT19
41 extragonadal germ cell cancer 10.1 AFP POU5F1
42 superior mesenteric artery syndrome 10.1 CDX2 KRT19
43 central nervous system germ cell tumor 10.1 AFP POU5F1
44 embryonal testis carcinoma 10.1 AFP POU5F1
45 intraneural perineurioma 10.1 KRT14 KRT19
46 intrahepatic bile duct adenoma 10.1 AFP KRT19
47 mature teratoma 10.1 AFP POU5F1
48 cribriform carcinoma 10.1 GATA3 KIT
49 renal pelvis adenocarcinoma 10.1 AFP KRT19
50 pineoblastoma 10.1 AFP POU5F1

Graphical network of the top 20 diseases related to Embryoma:



Diseases related to Embryoma

Symptoms & Phenotypes for Embryoma

MGI Mouse Phenotypes related to Embryoma:

47 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.15 CDX2 GATA3 GPC3 KIT KRT14 KRT19
2 endocrine/exocrine gland MP:0005379 10.15 AFP CDX2 GATA3 HNF1B KIT KRT14
3 digestive/alimentary MP:0005381 10.13 CDX2 GATA3 GPC3 KIT KRT14 KRT19
4 embryo MP:0005380 10.11 CDX2 GATA3 GPC3 HNF1B KIT KRT19
5 growth/size/body region MP:0005378 10.08 CDX2 GATA3 GPC3 HNF1B KIT KRT14
6 mortality/aging MP:0010768 10.07 AFP CDX2 GATA3 GPC3 HNF1B KIT
7 homeostasis/metabolism MP:0005376 10.06 AFP CDX2 GATA3 GPC3 HNF1B KIT
8 immune system MP:0005387 9.98 GATA3 GPC3 HNF1B KIT KRT14 SALL4
9 craniofacial MP:0005382 9.93 GATA3 GPC3 KIT KRT14 SALL4
10 integument MP:0010771 9.88 GATA3 GPC3 KIT KRT14 KRT19 POU5F1
11 neoplasm MP:0002006 9.72 AFP CDX2 KIT KRT14 KRT19
12 reproductive system MP:0005389 9.61 AFP CDX2 GATA3 GPC3 KIT KRT14
13 pigmentation MP:0001186 9.56 GATA3 GPC3 KIT KRT14
14 renal/urinary system MP:0005367 9.55 GATA3 GPC3 HNF1B KIT SALL4
15 skeleton MP:0005390 9.1 CDX2 GATA3 GPC3 KIT KRT19 SALL4

Drugs & Therapeutics for Embryoma

Drugs for Embryoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
2
Trastuzumab Approved, Investigational Phase 2 180288-69-1 9903
3
Adenosine Approved, Investigational Phase 2 58-61-7 60961
4 Lorvotuzumab mertansine Investigational Phase 2 1008106-64-6
5 Antineoplastic Agents, Alkylating Phase 2,Not Applicable
6 Alkylating Agents Phase 2,Not Applicable
7 Antineoplastic Agents, Phytogenic Phase 2,Not Applicable
8 Antimitotic Agents Phase 2,Not Applicable
9 Ado-trastuzumab emtansine Phase 2
10 Antibodies Phase 2
11 Maytansine Phase 2
12 Immunoglobulins Phase 2
13 Antibodies, Monoclonal Phase 2
14 Antineoplastic Agents, Immunological Phase 2
15
Cyclophosphamide Approved, Investigational Not Applicable 6055-19-2, 50-18-0 2907
16
Vincristine Approved, Investigational Not Applicable 2068-78-2, 57-22-7 5978
17
Ifosfamide Approved Not Applicable 3778-73-2 3690
18
Doxorubicin Approved, Investigational Not Applicable 23214-92-8 31703
19
Mechlorethamine Approved, Investigational Not Applicable 51-75-2 4033
20
Dactinomycin Approved, Investigational Not Applicable 50-76-0 457193 2019
21
Doxil Approved June 1999 Not Applicable 31703
22 Anti-Infective Agents Not Applicable
23 Immunosuppressive Agents Not Applicable
24
Isophosphamide mustard Not Applicable 0
25 Anti-Bacterial Agents Not Applicable
26 Immunologic Factors Not Applicable
27 Nucleic Acid Synthesis Inhibitors Not Applicable
28 Topoisomerase Inhibitors Not Applicable
29 Antibiotics, Antitubercular Not Applicable
30 Antirheumatic Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Hyperbaric Hyperoxygenation With Radiotherapy and Temozolomide in Adults With Newly Diagnosed Glioblastoma Unknown status NCT00936052 Phase 2
2 Lorvotuzumab Mertansine in Treating Younger Patients With Relapsed or Refractory Wilms Tumor, Rhabdomyosarcoma, Neuroblastoma, Pleuropulmonary Blastoma, Malignant Peripheral Nerve Sheath Tumor, or Synovial Sarcoma Active, not recruiting NCT02452554 Phase 2
3 Gene Mutation in Samples From Young Patients With Pleuropulmonary Blastoma Syndrome at Risk for Developing Cancer Completed NCT01353300
4 Review of the Paediatric Pleuropulmonary Blastoma French Series Recruiting NCT03044834
5 International Pleuropulmonary Blastoma (PPB) Treatment and Biology Registry Recruiting NCT01464606 Not Applicable Vincristine;Dactinomycin;Cyclophosphamide;Ifosfamide;Doxorubicin
6 DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study Recruiting NCT01247597
7 International PPB Registry for PPB, DICER1 and Associated Conditions Recruiting NCT03382158
8 International Ovarian & Testicular Stromal Tumor Registry Recruiting NCT01970696
9 Congenital Lung Anomalies (CLA) Swiss Database Recruiting NCT03044769
10 Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome Active, not recruiting NCT00565903

Search NIH Clinical Center for Embryoma

Genetic Tests for Embryoma

Anatomical Context for Embryoma

MalaCards organs/tissues related to Embryoma:

42
Kidney, Lung, Testis, Ovary, Salivary Gland, Thyroid, Cerebellum

The Foundational Model of Anatomy Ontology organs/tissues related to Embryoma:

20
Embryonic Tissue

Publications for Embryoma

Articles related to Embryoma:

(show top 50) (show all 62)
# Title Authors Year
1
Novel intronic DICER1 variation associated with pleuropulmonary blastoma in two siblings. ( 30665929 )
2019
2
Successful treatment of metastatic cerebral recurrence of pleuropulmonary blastoma. ( 30677214 )
2019
3
Wilms tumor, pleuropulmonary blastoma, and DICER1: case report and literature review. ( 30097050 )
2018
4
Pleuropulmonary Blastoma Developing in a Case of Misinterpreted Congenital Pulmonary Airway Malformation: a Case Report. ( 30358469 )
2018
5
Identification of Homozygous Somatic DICER1 Mutation in Pleuropulmonary Blastoma. ( 30585947 )
2018
6
Pulmonary Blastoma in an Adult Presenting with Hemoptysis and Hemothorax. ( 30365956 )
2018
7
Cure of Oligometastatic Classic Biphasic Pulmonary Blastoma Using Aggressive Tri-modality Treatment: Case Series and Review of the Literature. ( 30656089 )
2018
8
Temporal order of RNase IIIb and loss-of-function mutations during development determines phenotype in DICER1 syndrome: a unique variant of the two-hit tumor suppression model. ( 26925222 )
2015
9
Pleuropulmonary blastoma in children: a case report. ( 25628828 )
2012
10
Radical resection of pleuropulmonary blastoma. ( 27755807 )
2011
11
Congenital sialoblastoma (embryoma) associated with premature centromere division and high level of alpha-fetoprotein. ( 16049999 )
2005
12
Diffuse embryoma with intratubular germ-cell neoplasia. ( 15469489 )
2004
13
Sialoblastoma (embryoma): MR findings of a rare pediatric salivary gland tumor. ( 9159361 )
1997
14
Diffuse embryoma of the testis. ( 7726152 )
1995
15
Pleuro-pulmonary blastoma: a case report and review of the literature. ( 7565313 )
1995
16
Diffuse embryoma of the testis. An immunohistochemical study of two cases. ( 7524298 )
1994
17
Embryoma (sialoblastoma) of salivary glands. ( 1444105 )
1992
18
Pulmonary blastoma in childhood. ( 3807382 )
1987
19
Embryoma (or embryonal tumor) of the parotid gland: report of two cases. ( 3725707 )
1986
20
Diffuse embryoma of the testis. A distinctive form of mixed germ cell tumor. ( 6195930 )
1983
21
Pulmonary blastoma: case report and literature review. ( 998819 )
1976
22
Pulmonary blastoma (embryoma lung). A case report with review of literature. ( 1193668 )
1975
23
Renal embryoma in an adult. ( 4339834 )
1972
24
Metastatic renal embryoma: survival following therapy. ( 4293670 )
1967
25
Pulmonary blastoma (embryoma). Report of two cases. ( 5931363 )
1966
26
Pulmonary blastoma, a form of carcinosarcoma. Report of a case of 24 years' duration without treatment. ( 4288403 )
1966
27
EMBRYOMA OF KIDNEY IN NEWBORN INFANT: CASE REPORT. ( 14276199 )
1965
28
Radiologic seminar XV: Embryoma of the kidney (Wilm's tumor). ( 13952914 )
1963
29
Primary hepatic malignancy with particular reference to the embryoma of infancy. ( 14492775 )
1961
30
Malignant embryoma of the neural crest. ( 13746972 )
1960
31
Treatment of pulmonary metastases from malignant embryoma of the testicle with nitrofurazone ( 13820432 )
1960
32
Embryoma of the kidney (Wilms' tumor). ( 14403711 )
1960
33
Malignant melanoma or retino-blastoma in an adult. ( 13816282 )
1960
34
Renal embryoma. ( 13601962 )
1958
35
Polyembryonic embryoma of the ovary of parthenogenetic origin. ( 13426978 )
1957
36
Embryoma of the urinary bladder. ( 13368293 )
1956
37
Embryoma of the kidney; case report of a fourteen-year cure. ( 13334846 )
1956
38
Bilateral embryoma of the kidney; patient alive and well three years after treatment. ( 13336329 )
1956
39
Embryoma of the urinary bladder. ( 13359346 )
1955
40
Embryoma of lungs. ( 13015519 )
1952
41
Adrenogenital syndrome in a male child due to adrenocortical tumor; report of case with hemihypertrophy and subsequent development of embryoma (Wilms' tumor). ( 12983105 )
1952
42
Embryoma of the kidney (Wilms' tumor); a report on two recoveries. ( 14864825 )
1951
43
The effect of preoperative roentgen-ray therapy on arterial hypertension in embryoma (kidney). ( 15395003 )
1949
44
Embryoma of the kidney with symptoms at birth. ( 15409288 )
1949
45
Embryoma of contralateral kidney 10 years following nephrectomy for Wilms' tumor. ( 18130185 )
1949
46
Embryoma of kidney (Wilms' tumor) in children. ( 18137842 )
1949
47
Hypertension in embryoma; Wilms' tumor. ( 18111427 )
1949
48
Embryoma of the testicle in a 5-year old child. ( 18872800 )
1948
49
Wilms' tumor (embryoma of the kidney). ( 18896881 )
1947
50
Embryoma of the kidney in the adult. ( 20995867 )
1946

Variations for Embryoma

Expression for Embryoma

Search GEO for disease gene expression data for Embryoma.

Pathways for Embryoma

GO Terms for Embryoma

Biological processes related to Embryoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.8 GATA3 HNF1B KIT POU5F1
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.72 CDX2 GATA3 HNF1B POU5F1 SALL4
3 anatomical structure morphogenesis GO:0009653 9.61 GATA3 GPC3 POU5F1
4 kidney development GO:0001822 9.58 GATA3 GPC3 HNF1B
5 T cell differentiation GO:0030217 9.55 GATA3 KIT
6 ventricular septum development GO:0003281 9.54 GATA3 SALL4
7 blastocyst development GO:0001824 9.51 CDX2 POU5F1
8 embryonic hemopoiesis GO:0035162 9.48 GATA3 KIT
9 animal organ morphogenesis GO:0009887 9.46 CDX2 GPC3
10 epithelial cell proliferation GO:0050673 9.37 HNF1B KIT
11 endodermal cell fate specification GO:0001714 9.26 HNF1B POU5F1
12 tissue development GO:0009888 9.22 SALL4
13 mast cell differentiation GO:0060374 9.16 GATA3 KIT
14 nephric duct formation GO:0072179 8.96 GATA3 HNF1B
15 somatic stem cell population maintenance GO:0035019 8.92 CDX2 KIT POU5F1 SALL4

Molecular functions related to Embryoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.46 CDX2 GATA3 HNF1B POU5F1
2 cytokine binding GO:0019955 9.26 KIT POU5F1
3 proximal promoter sequence-specific DNA binding GO:0000987 8.96 GATA3 HNF1B
4 enhancer sequence-specific DNA binding GO:0001158 8.62 GATA3 POU5F1

Sources for Embryoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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