MCID: EMB004
MIFTS: 56

Embryonal Carcinoma

Categories: Rare diseases, Cancer diseases, Fetal diseases

Aliases & Classifications for Embryonal Carcinoma

MalaCards integrated aliases for Embryonal Carcinoma:

Name: Embryonal Carcinoma 12 53 59 15 73
Embryonal Neoplasm 12 73
Embryonal Cancer 12 15
Primary Extragonadal Embryonal Carcinoma 12
Extragonadal Embryonal Carcinoma 73
Carcinoma, Embryonal 44
Carcinoma Embryonal 55
Cancer, Embryonal 73
Cancer Embryonal 55
Embryo Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3308 DOID:688
SNOMED-CT 68 189843003 28047004
Orphanet 59 ORPHA180226
ICD10 via Orphanet 34 C22.7 C71.9
MESH via Orphanet 45 D018236
UMLS via Orphanet 74 C0206659

Summaries for Embryonal Carcinoma

NIH Rare Diseases : 53 Embryonal carcinoma is a type of testicular cancer, which is cancer that starts in the testicles, the male reproductive glands located in the scrotum. It most often develops in young and middle-aged men. It tends to grow rapidly and spread outside the testicle. Embryonal carcinomas are classified as nonseminoma germ celltumors. Most testicular cancers grow from germ cells, the cells that make sperm. Germ cell tumors are broadly divided into seminomas and nonseminomas because each type has a different prognosis and treatment regimen. Nonseminomas, which are more common, tend to grow more quickly than seminomas. Nonseminoma tumors are often made up of more than one type of cell, and are identified according to the different cell types.

MalaCards based summary : Embryonal Carcinoma, also known as embryonal neoplasm, is related to embryonal testis carcinoma and germ cell and embryonal cancer. An important gene associated with Embryonal Carcinoma is H19 (H19, Imprinted Maternally Expressed Transcript
H19 oncogenicity in hEC cells is mediated through the regulation of the pluripotency state.
Dysfunction Pattern: Regulation), and among its related pathways/superpathways are Human Embryonic Stem Cell Pluripotency and Mesodermal Commitment Pathway. The drugs Bleomycin and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include the ovaries or, ovary and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 An embryonal cancer that is a type of germ cell tumour that is located in the ovaries or located in the testes.

Wikipedia : 76 Embryonal carcinoma is a relatively uncommon type of germ cell tumour that occurs in the ovaries and... more...

Related Diseases for Embryonal Carcinoma

Diseases related to Embryonal Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 embryonal testis carcinoma 34.1 AFP POU5F1
2 germ cell and embryonal cancer 34.1 AFP POU5F1 SOX2
3 ovarian embryonal carcinoma 33.9 AFP POU5F1 SOX2 TNFRSF8
4 intratubular embryonal carcinoma 33.7 AFP KIT POU5F1 TNFRSF8
5 teratocarcinoma 33.1 FGF4 POU5F1 RARB TDGF1
6 mixed germ cell tumor 31.0 AFP KIT
7 seminoma 30.6 AFP KIT POU5F1 TNFRSF8
8 malignant teratoma 30.5 AFP POU5F1
9 teratoma 30.5 AFP KIT NES POU5F1 SOX2
10 childhood ovarian embryonal carcinoma 12.2
11 central nervous system embryonal carcinoma 12.1
12 adult central nervous system embryonal carcinoma 12.0
13 non-central nervous system-localized embryonal carcinoma 12.0
14 endodermal sinus tumor 11.8
15 testicular germ cell tumor 11.2
16 childhood embryonal testis carcinoma 11.2
17 brain germinoma 10.9 AFP POU5F1
18 childhood teratocarcinoma of the testis 10.9
19 pediatric cns embryonal cell carcinoma 10.9
20 extragonadal germ cell cancer 10.9 AFP POU5F1
21 hepatic angiomyolipoma 10.9 AFP KIT
22 polyembryoma 10.9
23 central nervous system teratoma 10.8 NES SOX2
24 hemihyperplasia, isolated 10.8
25 orbital cyst 10.7 GDF3 SOX2
26 venous hemangioma 10.6 POU5F1 SOX2
27 physical disorder 10.6 AFP BMP4 TUBB3
28 ovarian solid teratoma 10.6 AFP TNFRSF8
29 endometrial small cell carcinoma 10.6 AFP KIT
30 sternum cancer 10.6 AFP TNFRSF8
31 aggressive systemic mastocytosis 10.5 H19 KIT
32 mixed germ cell cancer 10.5 AFP POU5F1 TDGF1
33 central nervous system germ cell tumor 10.5 AFP NES POU5F1 SOX2
34 rete testis adenocarcinoma 10.5 AFP KIT
35 conventional fibrosarcoma 10.4 KIT TNFRSF8
36 microphthalmia 10.4 BMP4 GDF3 KIT RARB SOX2
37 neuronitis 10.4
38 marek disease 10.3 H19 TNFRSF8
39 testicular infarct 10.3 AFP KIT POU5F1 TNFRSF8
40 brain cancer 10.3 NES POU5F1 SOX2 TUBB3
41 cell type cancer 10.3 AFP KIT POU5F1 SOX2 TUBB3
42 malignant leydig cell tumor 10.3 KIT NES POU5F1 TNFRSF8
43 gastric cardia adenocarcinoma 10.2 H19 HOTAIR
44 mediastinal cancer 10.2 AFP KIT
45 extragonadal seminoma 10.1 AFP KIT POU5F1 SOX2 TNFRSF8
46 germ cells tumors 10.1
47 gastrointestinal system cancer 10.1 AFP H19 HOTAIR KIT
48 testicular germ cell tumor 1 10.0
49 gastric adenocarcinoma 9.9 AFP H19 HOTAIR KIT
50 ewing sarcoma 9.9 KIT NES POU5F1 SOX2 TNFRSF8

Graphical network of the top 20 diseases related to Embryonal Carcinoma:



Diseases related to Embryonal Carcinoma

Symptoms & Phenotypes for Embryonal Carcinoma

GenomeRNAi Phenotypes related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.4 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.4 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.4 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.4 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.4 POU5F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.4 NDN POU5F1 AFP
7 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.4 AFP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.4 POU5F1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.4 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.4 POU5F1

MGI Mouse Phenotypes related to Embryonal Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.23 GDF3 KIT NDN POU5F1 RARB RARG
2 embryo MP:0005380 10.1 BMP4 FGF4 GATA4 GDF3 KIT POU5F1
3 mortality/aging MP:0010768 10.07 AFP BMP4 FGF4 GATA4 GDF3 KIT
4 endocrine/exocrine gland MP:0005379 10.02 AFP BMP4 GATA4 KIT POU5F1 RARB
5 digestive/alimentary MP:0005381 9.98 BMP4 GATA4 KIT POU5F1 RARB RARG
6 integument MP:0010771 9.92 BMP4 GATA4 KIT NDN POU5F1 RARG
7 normal MP:0002873 9.9 NDN POU5F1 RARB RARG SOX2 TDGF1
8 reproductive system MP:0005389 9.61 RARB RARG SOX2 BMP4 FGF4 GATA4
9 respiratory system MP:0005388 9.28 BMP4 FGF4 GATA4 KIT NDN RARB

Drugs & Therapeutics for Embryonal Carcinoma

Drugs for Embryonal Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bleomycin Approved, Investigational Phase 2, Phase 3,Phase 3 11056-06-7 5360373
2
Cisplatin Approved Phase 2, Phase 3,Phase 3,Phase 1 15663-27-1 84093 441203 2767
3
Etoposide Approved Phase 2, Phase 3,Phase 3 33419-42-0 36462
4
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
5
Paclitaxel Approved, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1 33069-62-4 36314
6
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
7
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
8
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 43805 6857599
9
Captopril Approved Phase 3 62571-86-2 44093
10
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
11
Palivizumab Approved, Investigational Phase 3 188039-54-5
12
Ribavirin Approved Phase 3 36791-04-5 37542
13
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
14
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
15
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
16
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
17
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
18
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
19
Vinblastine Approved Phase 3 865-21-4 13342 241903
20 Albumin-Bound Paclitaxel Phase 2, Phase 3,Phase 3,Phase 1
21 Anti-Bacterial Agents Phase 2, Phase 3,Phase 3
22 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 3
23 Antimitotic Agents Phase 2, Phase 3,Phase 3,Phase 1
24 Antineoplastic Agents, Phytogenic Phase 2, Phase 3,Phase 3,Phase 1
25 Etoposide phosphate Phase 2, Phase 3,Phase 3
26 Topoisomerase Inhibitors Phase 2, Phase 3,Phase 3
27 Alkylating Agents Phase 3,Phase 1,Phase 2
28 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2
29
Isophosphamide mustard Phase 3,Phase 1,Phase 2 0
30 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
31 Anti-Infective Agents Phase 3,Phase 1,Phase 2
32 Antimetabolites Phase 3,Phase 1,Phase 2
33 Antiviral Agents Phase 3,Phase 1,Phase 2
34 Angiotensin-Converting Enzyme Inhibitors Phase 3
35 Antihypertensive Agents Phase 3
36 Antirheumatic Agents Phase 3
37 HIV Protease Inhibitors Phase 3
38
protease inhibitors Phase 3
39 Antibodies Phase 3,Phase 2,Phase 1
40 Antibodies, Monoclonal Phase 3,Phase 2,Phase 1
41 Immunoglobulins Phase 3,Phase 2,Phase 1
42 Antifungal Agents Phase 3
43 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
44 Cytochrome P-450 CYP3A Inhibitors Phase 3
45 Cytochrome P-450 Enzyme Inhibitors Phase 3
46 Hormone Antagonists Phase 3,Phase 1,Phase 2
47 Hormones Phase 3,Phase 1,Phase 2
48 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
49
Hydroxyitraconazole Phase 3
50 Steroid Synthesis Inhibitors Phase 3

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
3 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
4 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
5 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
6 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
7 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
8 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
9 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
10 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
11 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
12 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
13 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
14 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 paclitaxel;carboplatin;ifosfamide
15 Brentuximab Vedotin (SGN-35) as Salvage Treatment for CD30-positive Germ Cell Tumors Completed NCT01851200 Phase 2 Brentuximab Vedotin
16 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
17 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
18 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
19 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
20 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
21 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
22 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
23 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
24 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
25 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
26 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
27 Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
28 Brentuximab Vedotin in Relapsed/Refractory Germ Cell Tumors Recruiting NCT02689219 Phase 2 Brentuximab Vedotin
29 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
30 MEN-10755 in Treating Patients With Solid Tumors Completed NCT00003982 Phase 1 sabarubicin
31 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
32 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
33 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
34 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021 Not Applicable
35 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465 Not Applicable
36 Positron Emission Tomography in Detecting Testicle Cancer Completed NCT00045045 Not Applicable
37 Diagnostic Study of Patients With Stage I Testicular Cancer Completed NCT00003800 Not Applicable
38 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Completed NCT01080521
39 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Recruiting NCT01434355

Search NIH Clinical Center for Embryonal Carcinoma

Cochrane evidence based reviews: carcinoma, embryonal

Genetic Tests for Embryonal Carcinoma

Anatomical Context for Embryonal Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Embryonal Carcinoma:

19
The Ovaries Or

MalaCards organs/tissues related to Embryonal Carcinoma:

41
Ovary, Testes, Bone, Bone Marrow, Brain, Testis, Liver

Publications for Embryonal Carcinoma

Articles related to Embryonal Carcinoma:

(show top 50) (show all 392)
# Title Authors Year
1
DNA methylation of the Oct4A enhancers in embryonal carcinoma cells after etoposide treatment is associated with alternative splicing and altered pluripotency in reversibly senescent cells. ( 29372665 )
2018
2
Clinical Outcome of Retroperitoneal Lymph Node Dissection after Chemotherapy in Patients with Pure Embryonal Carcinoma in the Orchiectomy Specimen. ( 29410311 )
2018
3
New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells. ( 29439916 )
2018
4
Nuclear factor erythroid-2-related factor regulates LRWD1 expression and cellular adaptation to oxidative stress in human embryonal carcinoma cells. ( 29544732 )
2018
5
Delayed male germ cell sex-specification permits transition into embryonal carcinoma cells with features of primed pluripotency. ( 29545285 )
2018
6
The combined effects of three dimensional cell culture and natural tissue extract on neural differentiation of P19 embryonal carcinoma stem cells. ( 29905008 )
2018
7
The expression of the embryonic gene Cripto-1 is regulated by OCT4 in human embryonal carcinoma NCCIT cells. ( 29223130 )
2018
8
Mature Testicular Teratoma with a Focus of Embryonal Carcinoma: A Case Report and Review of Literature. ( 29770282 )
2018
9
Analysis of the Paternally-Imprinted DLK1-MEG3 and IGF2-H19 Tandem Gene Loci in NT2 Embryonal Carcinoma Cells Identifies DLK1 as a Potential Therapeutic Target. ( 29980981 )
2018
10
Imsnc761 and DDX6 synergistically suppress cell proliferation and promote apoptosis via p53 in testicular embryonal carcinoma cells. ( 29769412 )
2018
11
Embryonal carcinoma presenting as a calcified solitary testicular mass on ultrasound. ( 28765489 )
2017
12
Novel variant of OCT4B4 is differentially expressed in human embryonic stem and embryonic carcinoma cells. ( 28633916 )
2017
13
Whole brain radiotherapy with volumetric-modulated arc therapy for pediatric intracranial embryonic carcinoma prevents permanent alopecia. ( 28042910 )
2017
14
NANOG gene expression is regulated by the ETS transcription factor ETV4 in human embryonic carcinoma NCCIT cells. ( 28412366 )
2017
15
Brentuximab-vedotin maintenance following chemotherapy without irradiation for primary intracranial embryonal carcinoma in down syndrome. ( 29236132 )
2017
16
Distinct retinoic acid receptor (RAR) isotypes control differentiation of embryonal carcinoma cells to dopaminergic or striatopallidal medium spiny neurons. ( 29057906 )
2017
17
Embryonal Carcinoma with Immature Teratoma: A Homeopathic Case Report. ( 29080895 )
2017
18
Endobronchial Embryonal Carcinoma. ( 28323728 )
2017
19
Ovarian Embryonal Carcinoma in a Dog. ( 29169625 )
2017
20
Hsa-miR-513b-5p suppresses cell proliferation and promotes P53 expression by targeting IRF2 in testicular embryonal carcinoma cells. ( 28512062 )
2017
21
Mechanisms Regulating Stemness and Differentiation in Embryonal Carcinoma Cells. ( 28373885 )
2017
22
A Rare Case of Embryonal Carcinoma in a Patient with Turner Syndrome without Y Chromosomal Material but Mutations in KIT, AKT1, and ZNF358 Demonstrated Using Exome Sequencing. ( 29197878 )
2017
23
2102Ep embryonal carcinoma cells have compromised respiration and shifted bioenergetic profile distinct from H9 human embryonic stem cells. ( 28552560 )
2017
24
MyD88 is an essential component of retinoic acid-induced differentiation in human pluripotent embryonal carcinoma cells. ( 28885616 )
2017
25
In vitro induction of human embryonal carcinoma differentiation by a crude extract of Rhazya stricta. ( 28662725 )
2017
26
Increased expression of prion protein gene is accompanied by demethylation of CpG sites in a mouse embryonal carcinoma cell line, P19C6. ( 28132962 )
2017
27
Production of stable GFP-expressing neural cells from P19 embryonal carcinoma stem cells. ( 28013042 )
2016
28
Immature Teratoma with Embryonal Carcinoma; a Rare Malignant Mixed Germ Cell Tumor in a 13-Year-Old Girl. ( 26870146 )
2016
29
Inhibition of miR-29c promotes proliferation, and inhibits apoptosis and differentiation in P19 embryonic carcinoma cells. ( 26848028 )
2016
30
Non-Serotonergic Neurotoxicity by MDMA (Ecstasy) in Neurons Derived from Mouse P19 Embryonal Carcinoma Cells. ( 27861613 )
2016
31
Defining a New Prognostic Index for Stage I Nonseminomatous Germ Cell Tumors Using CXCL12 Expression and Proportion of Embryonal Carcinoma. ( 26453693 )
2016
32
Endobronchial Embryonal Carcinoma. ( 27623424 )
2016
33
SOX2 is essential for in vivo reprogramming of seminoma-like TCam-2 cells to an embryonal carcinoma-like fate. ( 27283990 )
2016
34
Autocrine glutamatergic transmission for the regulation of embryonal carcinoma stem cells. ( 27322683 )
2016
35
Testis peritubular myoid cells increase their motility and express matrix-metalloproteinase 9 (MMP-9) after interaction with embryonal carcinoma cells. ( 26711538 )
2016
36
Calmidazolium chloride inhibits growth of murine embryonal carcinoma cells, a model of cancer stem-like cells. ( 27247146 )
2016
37
Case report: Malignant germ cell tumour with predominant embryonal carcinoma component in a dysgenetic gonad. ( 27773100 )
2016
38
MicroRNA-29c overexpression inhibits proliferation and promotes apoptosis and differentiation in P19 embryonal carcinoma cells. ( 26484393 )
2016
39
Growth and Differentiation Factor 3 Is Transcriptionally Regulated by OCT4 in Human Embryonic Carcinoma Cells. ( 27803451 )
2016
40
Primary pure and nonsecreting embryonal carcinoma of the anterior third ventricle: a case report. ( 25832366 )
2015
41
Aggressive multimodal therapy may prolong disease-free survival in recurrent primary retroperitoneal embryonal carcinoma. ( 25799960 )
2015
42
The knockdown of H19lncRNA reveals its regulatory role in pluripotency and tumorigenesis of human embryonic carcinoma cells. ( 26415227 )
2015
43
Downregulation of miR-320a/383-sponge-like long non-coding RNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation. ( 26539909 )
2015
44
BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma. ( 26226633 )
2015
45
Metastatic embryonal carcinoma mimicking locally advanced non-small cell lung cancer. ( 25742895 )
2015
46
Transcription factor NF-Y inhibits cell growth and decreases SOX2 expression in human embryonal carcinoma cell line NT2/D1. ( 25756534 )
2015
47
Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide. ( 26102294 )
2015
48
Pulmonary artery stenosis due to embryonal carcinoma with primary mediastinal location. ( 25754058 )
2015
49
Embryonal Carcinoma in Cryptorchid Abdominal Testis of an Infant. ( 26137335 )
2015
50
NgR1 Expressed in P19 Embryonal Carcinoma Cells Differentiated by Retinoic Acid Can Activate STAT3. ( 25729271 )
2015

Variations for Embryonal Carcinoma

Expression for Embryonal Carcinoma

Search GEO for disease gene expression data for Embryonal Carcinoma.

Pathways for Embryonal Carcinoma

GO Terms for Embryonal Carcinoma

Cellular components related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor complex GO:0090575 8.8 GATA4 RARB RARG

Biological processes related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.99 BMP4 FGF4 KIT RARB RARG TDGF1
2 positive regulation of gene expression GO:0010628 9.97 BMP4 FGF4 KIT POU5F1 RARG
3 positive regulation of cell proliferation GO:0008284 9.97 BMP4 FGF4 KIT RARB RARG TDGF1
4 positive regulation of transcription by RNA polymerase II GO:0045944 9.97 BMP4 FGF4 GATA4 NDN POU5F1 RARB
5 positive regulation of cell migration GO:0030335 9.93 BMP4 KIT PODXL TDGF1
6 BMP signaling pathway GO:0030509 9.84 BMP4 GDF3 TDGF1
7 heart development GO:0007507 9.83 BMP4 GATA4 RARB RARG TDGF1
8 regulation of gene expression GO:0010468 9.8 BMP4 FGF4 POU5F1 RARG SOX2
9 steroid hormone mediated signaling pathway GO:0043401 9.79 BMP4 RARB RARG
10 SMAD protein signal transduction GO:0060395 9.79 AFP BMP4 GDF3
11 cell development GO:0048468 9.78 BMP4 GATA4 GDF3
12 bone development GO:0060348 9.76 BMP4 RARB RARG
13 retinoic acid receptor signaling pathway GO:0048384 9.67 RARB RARG
14 regulation of myelination GO:0031641 9.67 RARB RARG
15 cardiac right ventricle morphogenesis GO:0003215 9.66 BMP4 GATA4
16 embryonic camera-type eye development GO:0031076 9.65 NES RARG
17 endocardial cushion development GO:0003197 9.65 BMP4 GATA4
18 positive regulation of programmed cell death GO:0043068 9.65 RARB RARG
19 multicellular organism development GO:0007275 9.65 BMP4 FGF4 GDF3 KIT NES POU5F1
20 embryonic eye morphogenesis GO:0048048 9.64 RARB RARG
21 negative regulation of cartilage development GO:0061037 9.64 RARB RARG
22 endoderm development GO:0007492 9.63 BMP4 GATA4 GDF3
23 glomerular visceral epithelial cell development GO:0072015 9.62 BMP4 PODXL
24 growth plate cartilage development GO:0003417 9.6 RARB RARG
25 gland development GO:0048732 9.59 RARB RARG
26 retinal pigment epithelium development GO:0003406 9.57 RARB RARG
27 lymphoid progenitor cell differentiation GO:0002320 9.56 BMP4 KIT
28 somatic stem cell population maintenance GO:0035019 9.56 KIT POU5F1 SOX2 TDGF1
29 cranial suture morphogenesis GO:0060363 9.55 BMP4 FGF4
30 endodermal cell fate specification GO:0001714 9.54 POU5F1 SOX2
31 regulation of cell fate commitment GO:0010453 9.52 BMP4 GDF3
32 negative regulation of chondrocyte differentiation GO:0032331 9.5 BMP4 RARB RARG
33 glandular epithelial cell development GO:0002068 9.48 RARB RARG
34 epithelium development GO:0060429 9.33 BMP4 RARB RARG
35 embryonic hindlimb morphogenesis GO:0035116 8.92 BMP4 FGF4 RARB RARG
36 cell differentiation GO:0030154 10.15 BMP4 FGF4 KIT RARB RARG TDGF1
37 negative regulation of cell proliferation GO:0008285 10.03 BMP4 NDN RARB RARG TNFRSF8

Molecular functions related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 BMP4 FGF4 GDF3 TDGF1
2 transcription factor activity, direct ligand regulated sequence-specific DNA binding GO:0098531 9.37 RARB RARG
3 retinoid X receptor binding GO:0046965 9.32 RARB RARG
4 retinoic acid receptor activity GO:0003708 9.16 RARB RARG
5 transcription factor activity, RNA polymerase II transcription factor binding GO:0001076 9.13 GATA4 RARB RARG
6 transcription regulatory region sequence-specific DNA binding GO:0000976 8.92 POU5F1 RARB RARG SOX2

Sources for Embryonal Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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