Embryonal Carcinoma

Categories: Cancer diseases, Fetal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Embryonal Carcinoma

MalaCards integrated aliases for Embryonal Carcinoma:

Name: Embryonal Carcinoma 12 52 58 15 17 71
Embryonal Neoplasm 12 17 71
Embryonal Cancer 12 15
Primary Extragonadal Embryonal Carcinoma 12
Extragonadal Embryonal Carcinoma 71
Carcinoma, Embryonal 43
Carcinoma Embryonal 54
Cancer, Embryonal 71
Cancer Embryonal 54
Embryo Neoplasm 12


External Ids:

Disease Ontology 12 DOID:3308 DOID:688
SNOMED-CT 67 28047004
MESH via Orphanet 44 D018236
ICD10 via Orphanet 33 C22.7 C71.9
UMLS via Orphanet 72 C0206659
Orphanet 58 ORPHA180226
UMLS 71 C0027654 C0206659 C0751364 more

Summaries for Embryonal Carcinoma

NIH Rare Diseases : 52 Embryonal carcinoma is a type of testicular cancer , which is cancer that starts in the testicles, the male reproductive glands located in the scrotum. It most often develops in young and middle-aged men. It tends to grow rapidly and spread outside the testicle. Embryonal carcinomas are classified as nonseminoma germ cell tumors . Most testicular cancers grow from germ cells , the cells that make sperm. Germ cell tumors are broadly divided into seminomas and nonseminomas because each type has a different prognosis and treatment regimen. Nonseminomas, which are more common, tend to grow more quickly than seminomas. Nonseminoma tumors are often made up of more than one type of cell, and are identified according to the different cell types.

MalaCards based summary : Embryonal Carcinoma, also known as embryonal neoplasm, is related to ovarian embryonal carcinoma and intratubular embryonal carcinoma. An important gene associated with Embryonal Carcinoma is H19 (H19 Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways are Pathways in cancer and Mesodermal Commitment Pathway. The drugs Lenograstim and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include ovaries, testes and testis, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 An embryonal cancer that is a type of germ cell tumour that is located in the ovaries or located in the testes.

Wikipedia : 74 Embryonal carcinoma is a relatively uncommon type of germ cell tumour that occurs in the ovaries and... more...

Related Diseases for Embryonal Carcinoma

Diseases related to Embryonal Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 276)
# Related Disease Score Top Affiliating Genes
1 ovarian embryonal carcinoma 34.6 TNFRSF8 SOX2 POU5F1 AFP
2 intratubular embryonal carcinoma 34.3 TNFRSF8 POU5F1 KIT AFP
3 endodermal sinus tumor 33.5 TNFRSF8 POU5F1 MIR302A KIT AFP
4 teratocarcinoma 33.4 TDGF1 RARB RARA POU5F1 MIR302A FGF4
5 germ cell and embryonal cancer 33.3 TDGF1 SOX2 POU5F1 NES MIR302A KIT
6 teratoma 31.3 SOX2 POU5F1 NES KIT H19 AFP
7 mixed germ cell tumor 31.2 KIT AFP
8 seminoma 31.2 TNFRSF8 SOX2 POU5F1 KIT AFP
9 dysgerminoma 31.0 POU5F1 KIT AFP
10 ovarian germ cell cancer 30.6 POU5F1 KIT AFP
11 mature teratoma 30.6 TNFRSF8 POU5F1 MIR302A KIT AFP
12 malignant teratoma 30.6 TNFRSF8 SOX2 POU5F1 KIT AFP
13 mediastinum seminoma 30.5 KIT AFP
14 central nervous system germinoma 30.4 POU5F1 MIR302A
15 dysgerminoma of ovary 30.4 POU5F1 KIT AFP
16 germinoma 30.4 POU5F1 MIR302A KIT ESRG AFP
17 brain germinoma 30.4 POU5F1 KIT ESRG AFP
18 germ cell cancer 30.1 SOX2 POU5F1 NES MIR302A KIT H19
19 wilms tumor 1 30.0 PODXL KIT H19 AFP
20 neuroblastoma 29.7 SOX2 POU5F1 NES KIT HOTAIR H19
21 medulloblastoma 29.3 SOX2 POU5F1 NES KIT HOTAIR H19
22 childhood ovarian embryonal carcinoma 12.5
23 central nervous system embryonal carcinoma 12.4
24 adult central nervous system embryonal carcinoma 12.3
25 non-central nervous system-localized embryonal carcinoma 12.3
26 embryonal testis carcinoma 12.2
27 testicular germ cell tumor 12.0
28 childhood embryonal testis carcinoma 11.5
29 polyembryoma 11.5
30 pediatric cns embryonal cell carcinoma 11.4
31 childhood teratocarcinoma of the testis 11.2
32 atypical teratoid rhabdoid tumor 11.1
33 hemihyperplasia, isolated 11.1
34 kidney rhabdoid cancer 11.1
35 simpson-golabi-behmel syndrome 11.1
36 extragonadal seminoma 10.7 KIT AFP
37 pediatric testicular germ cell tumor 10.6 POU5F1 AFP
38 pineal region teratoma 10.6 KIT AFP
39 gallbladder leiomyosarcoma 10.6 KIT AFP
40 ovarian endodermal sinus tumor 10.6 POU5F1 AFP
41 liver leiomyoma 10.6 KIT AFP
42 liver lymphoma 10.6 FGF4 AFP
43 central nervous system immature teratoma 10.6 SOX2 NES
44 ovarian primitive germ cell tumor 10.6 POU5F1 AFP
45 testicular malignant germ cell cancer 10.6 GDF3 AFP
46 hypercarotenemia and vitamin a deficiency, autosomal dominant 10.6 RARS1 RARB RARA
47 ovarian mixed germ cell neoplasm 10.6 KIT AFP
48 hepatic angiomyolipoma 10.6 KIT AFP
49 tyrosinemia 10.5 SOX2 POU5F1 AFP
50 hypervitaminosis a 10.5 RARS1 RARA CRABP2

Graphical network of the top 20 diseases related to Embryonal Carcinoma:

Diseases related to Embryonal Carcinoma

Symptoms & Phenotypes for Embryonal Carcinoma

GenomeRNAi Phenotypes related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.28 NDN
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-114 9.28 AFP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 9.28 AFP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.28 NDN
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.28 AFP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.28 AFP
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.28 AFP
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.28 AFP NDN

MGI Mouse Phenotypes related to Embryonal Carcinoma:

# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.91 BMP4 FGF4 GDF3 KIT POU5F1 RARA
2 normal MP:0002873 9.65 BMP4 FGF4 GDF3 KIT NDN POU5F1
3 hearing/vestibular/ear MP:0005377 9.63 BMP4 CRABP2 KIT RARA RARB SOX2
4 respiratory system MP:0005388 9.17 BMP4 FGF4 KIT NDN RARA RARB

Drugs & Therapeutics for Embryonal Carcinoma

Drugs for Embryonal Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 131)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Lenograstim Approved, Investigational Phase 3 135968-09-1
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
Captopril Approved Phase 3 62571-86-2 44093
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
Ribavirin Approved Phase 3 36791-04-5 37542
Palivizumab Approved, Investigational Phase 3 188039-54-5
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 2826718 468682
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
Etoposide Approved Phase 3 33419-42-0 36462
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
Ifosfamide Approved Phase 3 3778-73-2 3690
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
Vinblastine Approved Phase 3 865-21-4 241903 13342
19 Liver Extracts Phase 3
20 Antihypertensive Agents Phase 3
21 Immunosuppressive Agents Phase 3
22 Angiotensin-Converting Enzyme Inhibitors Phase 3
23 HIV Protease Inhibitors Phase 3
protease inhibitors Phase 3
25 Antirheumatic Agents Phase 3
26 Cytochrome P-450 Enzyme Inhibitors Phase 3
27 Anti-Infective Agents Phase 3
28 Hormone Antagonists Phase 3
29 Hormones Phase 3
Hydroxyitraconazole Phase 3
31 Antifungal Agents Phase 3
32 Cytochrome P-450 CYP3A Inhibitors Phase 3
33 Antiviral Agents Phase 3
34 Amebicides Phase 3
35 Antiparasitic Agents Phase 3
36 Antiprotozoal Agents Phase 3
37 Liposomal amphotericin B Phase 3
38 Podophyllotoxin Phase 3 518-28-5
39 Keratolytic Agents Phase 3
40 Etoposide phosphate Phase 3
41 Antibiotics, Antitubercular Phase 3
42 Anti-Bacterial Agents Phase 3
43 Albumin-Bound Paclitaxel Phase 3
44 Tubulin Modulators Phase 3
45 Alkylating Agents Phase 3
Isophosphamide mustard Phase 3 0
47 Antimitotic Agents Phase 3
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
Furosemide Approved, Vet_approved Phase 1, Phase 2 54-31-9 3440
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1, Phase 2 1177-87-3

Interventional clinical trials:

(show top 50) (show all 62)
# Name Status NCT ID Phase Drugs
1 A Phase III Study Of Reduced Therapy In The Treatment Of Children With Low And Intermediate Risk Extracranial Germ Cell Tumors Unknown status NCT00053352 Phase 3 cisplatin;etoposide
2 Randomized Phase II/III Study of Taxol/Paclitaxel-BEP Versus BEP in Patients With Intermediate Prognosis Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
3 A Randomized Phase III Study of Sequential High-Dose Cisplatinum/Etoposide/Ifosfamide Plus Stem Cell Support Versus BEP in Patients With Poor Prognosis Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
4 Phase III Study of Captopril in Patients Undergoing Autologous Bone Marrow/Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
5 A Randomized, Comparative Study of Itraconazole Versus Fluconazole for Prevention of Aspergillus Infections in Peripheral Blood Stem Cell and Marrow Transplant Recipients Completed NCT00003883 Phase 3 fluconazole;itraconazole
6 A Randomized Double-Blind Placebo-Controlled Phase III Study To Evaluate The Safety And Efficacy Of Palivizumab Combined With Aerosolized Ribavirin Compared To Ribavirin Alone To Treat RSV Pneumonia In Patients With Bone Marrow Transplants (BMT) Completed NCT00014391 Phase 3 ribavirin
8 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
9 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
10 SIOP Intracranial Germ Cell Tumours Protocol Completed NCT00293358 Phase 3 carboplatin;cisplatin;etoposide phosphate;ifosfamide
11 A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide;Etoposide Phosphate
12 A Risk-Adapted Strategy of the Use of Dose-Dense Chemotherapy in Patients With Poor-Prognosis Disseminated Non-Seminomatous Germ Cell Tumors Active, not recruiting NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
13 A Randomized Phase III Study of Paclitaxel, Ifosfamide and Cisplatin Versus Vinblastine, Ifosfamide and Cisplatin as Second-Line Therapy for Patients With Relapsed/Resistant Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
14 Phase I/II Multicentre Trial of Salvage Chemotherapy With Gem-TIP for Relapsed Germ Cell Cancer Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
15 Treatment of Recurrent or Resistant Pediatric Malignant Germ Cell Tumors With Paclitaxel, Ifosfamide and Carboplatin Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
16 A Phase II Study of BMS-247550 In Advanced Germ Cell Tumor Patients - THERAPEUTIC/DIAGNOSTIC PROTOCOL Completed NCT00070096 Phase 2 ixabepilone
17 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
18 Accelerated BEP Chemotherapy for Intermediate and High Risk Metastatic Germ Cell Tumor Completed NCT00453232 Phase 2 cisplatin;etoposide
19 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
20 A Study of Paclitaxel, Cisplatin and Ifosfamide as Induction Therapy in the Treatment of Patients Relapsing After BEP Chemotherapy for Metastatic Germ Cell Tumors Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
21 Tandem High-Dose Chemotherapy With Autologous Stem Cell Rescue for Poor-Prognosis Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
22 Combination of Interleukin 11 (Neumega) With G-CSF to Mobilize Autologous Peripheral Blood Stem Cells (PBSC) Completed NCT00004157 Phase 2
23 Donor Lymphocyte Infusion (DLI) as Adoptive Immunotherapy for Relapse Malignancies After Allogeneic Hematopoietic Transplantation Completed NCT00003887 Phase 2
24 Oral Beclomethasone Dipropionate Capsules for Treatment of Intestinal Graft-Versus-Host Disease: Compassionate Use in Patients With Contraindictions to High-Dose Immunosuppressive Therapy Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
25 Cytokine-Based Immunotherapy Following High-Dose Chemotherapy and Autologous Stem Cell Transplantation Completed NCT00003408 Phase 2
27 Randomized Phase II Trial of Intensive Induction Chemotherapy (CBOP/BEP) and Standard BEP Chemotherapy in Poor Prognosis Male Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
28 Brentuximab Vedotin (SGN-35) as Salvage Therapy for Males With Advanced and Platinum-resistant Germ-cell Tumors. An Open Label, Single Group, Phase 2 Trial. Completed NCT01851200 Phase 2 Brentuximab Vedotin
29 A Prospective Evaluation of a Palliative Radio-Surgical Approach for the Treatment of Gynecologic Malignancies Completed NCT01079832 Phase 2
30 Psychosexual Intervention for Gynecologic and Breast Cancer Patients Completed NCT01764802 Phase 2
31 Prevention of DMSO-Related Nausea and Vomiting by Prophylactic Administration of Ondansetron for Patients Receiving Autologous Cryopreserved Peripheral Blood Stem Cells Completed NCT00795769 Phase 2 ondansetron
32 Phase II Study of Avelumab in Multiple Relapsed/Refractory Testicular Germ Cell Cancer. Completed NCT03403777 Phase 2 Avelumab
33 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
34 Secured Access to Pembrolizumab for Patients With Selected Rare Cancer Types Recruiting NCT03012620 Phase 2 Pembrolizumab
35 A Randomized Placebo Controlled Phase II Trial of Metformin in Conjunction With Chemotherapy Followed by Metformin Maintenance Therapy in Advanced Stage Ovarian, Fallopian Tube and Primary Peritoneal Cancer Recruiting NCT02122185 Phase 2 metformin hydrochloride;placebo;Chemotherapy
36 A Phase II, Multi-center, Open-label Study of a Conditionally Replicative Adenovirus (DNX-2401) With Pembrolizumab (KEYTRUDA®) for Recurrent Glioblastoma or Gliosarcoma (CAPTIVE/KEYNOTE-192) Active, not recruiting NCT02798406 Phase 2
37 A Multicenter Phase II Study of Brentuximab Vedotin in Relapsed/Refractory Germ Cell Tumors Terminated NCT02689219 Phase 2 Brentuximab Vedotin
38 Deferasirox Treatment and Labile Plasma Iron in Iron Overloaded Patients Who Have Undergone Allogeneic Hematopoietic Stem Cell Transplantation Terminated NCT01159067 Phase 2 deferasirox
39 CTLA-4 Blockade With MDX-010 to Induce Graft-Versus-Malignancy Effects Following Allogeneic Hematopoietic Stem Cell Transplantation Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
40 A Phase I Trial of Recombinant Human Interleukin-12 After High-Dose Therapy and Autologous Hematopoietic Stem Cell Support Completed NCT00003107 Phase 1
41 Phase I Clinical Trial of Temsirolimus and Vinorelbine in Advanced Solid Tumors. Completed NCT01155258 Phase 1 temsirolimus;vinorelbine ditartrate
42 Phase I Study to Determine the Safety of MEN-10755 (BMS-195615) in Patients With a Solid Tumor on a Short I.V. Infusion Given Once Every Week for 3 Consecutive Weeks, Followed by One Week's Rest Completed NCT00003982 Phase 1 sabarubicin
43 Prolonged Infusion Compared to Standard Infusion Cefepime as Empiric Treatment of Febrile Neutropenia: A Pilot Study Completed NCT01484015 Phase 1 cefepime hydrochloride
44 A Phase I Study of Active Immunotherapy With Carcinoembryonic Antigen RNA-Pulsed, Autologous Human Cultured Dendritic Cells in Patients With Metastatic Malignancies Expressing Carcinoembryonic Antigen Completed NCT00004604 Phase 1
45 Phase I Study of CCI-779 (NSC 683864) in Combination With Carboplatin and Paclitaxel in Patients With Advanced Solid Tumours Completed NCT00408655 Phase 1 paclitaxel;carboplatin;temsirolimus
46 A Phase I Study of UCN-01 in Combination With Irinotecan in Resistant Solid Tumor Malignancies (Part I) and in Triple Negative (ER-Negative, PgR-Negative, HER-2 Not-Amplified) Recurrent Breast Cancers (Part II) Completed NCT00031681 Phase 1 7-hydroxystaurosporine;irinotecan hydrochloride
47 A Phase I Dose Escalation Study of a 2 Day Oral Lapatinib Chemosensitization Pulse Given Prior To Weekly Intravenous Abraxane™ in Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
48 A Phase I Study of Infusion of HER-2/Neu Specific T Cells in Patients With Advanced Stage HER-2/Neu Expressing Cancers Who Have Received a HER-2/Neu Vaccine Completed NCT00228358 Phase 1 ex vivo-expanded HER2-specific T cells;cyclophosphamide
49 A Phase I Study of a DNA Plasmid Based Vaccine Encoding the HER-2/Neu Intracellular Domain in Subjects With HER-2/Neu (HER2) Overexpressing Tumors Active, not recruiting NCT00436254 Phase 1
50 A Phase I Study of ABT-888 in Combination With Oxaliplatin and Capecitabine in Advanced Solid Tumors Terminated NCT01233505 Phase 1 veliparib;capecitabine;oxaliplatin

Search NIH Clinical Center for Embryonal Carcinoma

Cochrane evidence based reviews: carcinoma, embryonal

Genetic Tests for Embryonal Carcinoma

Anatomical Context for Embryonal Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Embryonal Carcinoma:

Ovaries, Testes

MalaCards organs/tissues related to Embryonal Carcinoma:

Testis, Ovary, Testes, Brain, Lymph Node, Pineal, Bone

Publications for Embryonal Carcinoma

Articles related to Embryonal Carcinoma:

(show top 50) (show all 4193)
# Title Authors PMID Year
Alpha-fetoprotein-producing non-germ cell tumours of the female genital tract. 61 54
20185298 2010
Expression of embryonic stem cell markers in cultured JKT-1, a cell line derived from a human seminoma. 61 54
19226408 2010
Analysis of SOX2 expression in developing human testis and germ cell neoplasia. 61 54
19876845 2010
Necdin: a multi functional protein with potential tumor suppressor role? 61 54
19626646 2009
Tumour microvessel endothelial cell KIT and stem cell factor expression in human solid tumours. 54 61
19912360 2009
Reprogramming of Xist against the pluripotent state in fusion hybrids. 54 61
19843582 2009
The role of promoter CpG methylation in the epigenetic control of stem cell related genes during differentiation. 61 54
19221495 2009
Midkine translocated to nucleoli and involved in carcinogenesis. 61 54
19152444 2009
miR-302b maintains "stemness" of human embryonal carcinoma cells by post-transcriptional regulation of Cyclin D2 expression. 61 54
18930031 2008
Expression of RALDHs (ALDH1As) and CYP26s in human tissues and during the neural differentiation of P19 embryonal carcinoma stem cell. 54 61
18502188 2008
Nestin expression in central nervous system germ cell tumors. 54 61
18092184 2008
Regulation of human Cripto-1 gene expression by TGF-beta1 and BMP-4 in embryonal and colon cancer cells. 54 61
17941089 2008
Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. 54 61
18045648 2008
Dynamic and selective interactions of the transcriptional corepressor TIF1 beta with the heterochromatin protein HP1 isotypes during cell differentiation. 54 61
17381543 2007
Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells. 61 54
17663992 2007
Selective repression of retinoic acid target genes by RIP140 during induced tumor cell differentiation of pluripotent human embryonal carcinoma cells. 61 54
17880687 2007
Testicular maturation arrest to testis cancer: spectrum of expression of the vitamin D receptor and vitamin D treatment in vitro. 54 61
17644135 2007
Transcriptional regulation of human Oct4 by steroidogenic factor-1. 54 61
17226773 2007
[Malignant ovarian germ cell tumours: a trial of 36 cases]. 54 61
17350873 2007
Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract. 54 61
17314394 2007
Q2ChIP, a quick and quantitative chromatin immunoprecipitation assay, unravels epigenetic dynamics of developmentally regulated genes in human carcinoma cells. 61 54
17272500 2007
OCT4: biological functions and clinical applications as a marker of germ cell neoplasia. 54 61
17117392 2007
Elevating the levels of Sox2 in embryonal carcinoma cells and embryonic stem cells inhibits the expression of Sox2:Oct-3/4 target genes. 61 54
17324942 2007
Nestin is expressed in the basal/myoepithelial layer of the mammary gland and is a selective marker of basal epithelial breast tumors. 54 61
17234757 2007
Oncofetal protein glypican-3 in testicular germ-cell tumor. 54 61
16896894 2006
Differential activity of the FGF-4 enhancer in F9 and P19 embryonal carcinoma cells. 61 54
16523502 2006
Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. 61 54
16793513 2006
OAZ regulates bone morphogenetic protein signaling through Smad6 activation. 61 54
16373339 2006
Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors. 61 54
16424014 2006
The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation. 61 54
16344469 2005
CD30 (Ki-1) molecule expression in human embryonal epithelial cells of the basal layer of the developing epidermis and epidermal buds and its potential significance for embryogenesis. 54 61
16200333 2005
Distal enhancer of the mouse FGF-4 gene and its human counterpart exhibit differential activity: critical role of a GT box. 54 61
15803454 2005
Differentiation of human embryonal carcinomas in vitro and in vivo reveals expression profiles relevant to normal development. 54 61
15994931 2005
Targeted inhibition of the transcription factor YY1 in an embryonal carcinoma cell line results in retarded cell growth, elevated levels of p53 but no increase in apoptotic cell death. 54 61
16003908 2005
Overexpression of anti-apoptotic Mcl-1 in testicular germ cell tumours. 61 54
15842635 2005
OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma. 54 61
15725806 2005
Human embryonal epithelial cells of the developing small intestinal crypts can express the Hodgkin-cell associated antigen Ki-1 (CD30) in spontaneous abortions during the first trimester of gestation. 54 61
15644135 2005
Retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells is potentiated by leukemia inhibitory factor. 61 54
15641927 2005
NF-Y behaves as a bifunctional transcription factor that can stimulate or repress the FGF-4 promoter in an enhancer-dependent manner. 61 54
16128003 2005
Oncogenic role of NALP7 in testicular seminomas. 54 61
15596043 2004
Sox7 plays crucial roles in parietal endoderm differentiation in F9 embryonal carcinoma cells through regulating Gata-4 and Gata-6 expression. 54 61
15542856 2004
Transcription factor Sox-2 inhibits co-activator stimulated transcription. 54 61
15349837 2004
Association of the transcriptional corepressor TIF1beta with heterochromatin protein 1 (HP1): an essential role for progression through differentiation. 54 61
15342492 2004
Necdin interacts with the Msx2 homeodomain protein via MAGE-D1 to promote myogenic differentiation of C2C12 cells. 54 61
15272023 2004
Receptor interacting protein 140 as a thyroid hormone-dependent, negative co-regulator for the induction of cellular retinoic acid binding protein I gene. 61 54
15130509 2004
Specific knockdown of Oct4 and beta2-microglobulin expression by RNA interference in human embryonic stem cells and embryonic carcinoma cells. 61 54
15342930 2004
Negative feedback at the level of nuclear receptor coregulation. Self-limitation of retinoid signaling by RIP140. 61 54
14506269 2003
Oct-4-expressing cells in human amniotic fluid: a new source for stem cell research? 61 54
12832377 2003
p27 and cyclin E/D2 associations in testicular germ cell tumors: implications for tumorigenesis. 61 54
12777997 2003
Islet cell hyperplasia in transgenic mice overexpressing EAT/mcl-1, a bcl-2 related gene. 61 54
12782407 2003

Variations for Embryonal Carcinoma

Cosmic variations for Embryonal Carcinoma:

# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM88315457 KIT ovary,NS,germ cell tumour,embryonal carcinoma c.1965T>A p.N655K 4:54728096-54728096 6
2 COSM133536937 AKT1 ovary,NS,germ cell tumour,embryonal carcinoma c.967G>A p.D323N 14:104773083-104773083 6
3 COSM105585949 ovary,NS,germ cell tumour,embryonal carcinoma c.967G>A p.D323N 14:104773083-104773083 6
4 COSM134536549 ovary,NS,germ cell tumour,embryonal carcinoma c.967G>A p.D323N 14:104773083-104773083 6
5 COSM103843275 ovary,NS,germ cell tumour,embryonal carcinoma c.967G>A p.D323N 14:104773083-104773083 6
6 COSM89234463 ovary,NS,germ cell tumour,embryonal carcinoma c.967G>A p.D323N 14:104773083-104773083 6
7 COSM136350617 ovary,NS,germ cell tumour,embryonal carcinoma c.967G>A p.D323N 14:104773083-104773083 6

Expression for Embryonal Carcinoma

Search GEO for disease gene expression data for Embryonal Carcinoma.

Pathways for Embryonal Carcinoma

Pathways related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
4 11.91 TDGF1 SOX2 POU5F1 BMP4 AFP
5 11.68 TDGF1 KIT FGF4 BMP4
6 11.57 SOX2 NES FGF4 BMP4
Show member pathways
8 11.49 SOX2 POU5F1 MIR302A
Show member pathways
11.39 TDGF1 SOX2 POU5F1
10 11.37 KIT FGF4 BMP4
14 11.18 SOX2 POU5F1 KIT BMP4
15 10.73 SOX2 POU5F1 FGF4
Show member pathways
10.13 SOX2 POU5F1 BMP4

GO Terms for Embryonal Carcinoma

Biological processes related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.18 TNFRSF8 TDGF1 RARB RARA KIT GDF3
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.14 SOX2 RARB RARA POU5F1 NDN FGF4
3 positive regulation of cell proliferation GO:0008284 10.04 TDGF1 RARA KIT FGF4 BMP4
4 negative regulation of apoptotic process GO:0043066 10.04 TDGF1 RARB RARA FGF4 BMP4
5 positive regulation of gene expression GO:0010628 10.02 RARA POU5F1 KIT FGF4 BMP4
6 negative regulation of cell proliferation GO:0008285 10 TNFRSF8 RARB RARA NDN BMP4
7 cell differentiation GO:0030154 10 TDGF1 SOX2 RARB RARA POU5F1 FGF4
8 positive regulation of cell migration GO:0030335 9.93 TDGF1 PODXL KIT BMP4
9 positive regulation of neuron differentiation GO:0045666 9.83 RARB RARA BMP4
10 bone development GO:0060348 9.76 RARB RARA BMP4
11 SMAD protein signal transduction GO:0060395 9.75 GDF3 BMP4 AFP
12 steroid hormone mediated signaling pathway GO:0043401 9.72 RARB RARA BMP4
13 retinoic acid receptor signaling pathway GO:0048384 9.65 RARB RARA
14 negative regulation of pri-miRNA transcription by RNA polymerase II GO:1902894 9.65 POU5F1 BMP4
15 embryonic camera-type eye development GO:0031076 9.63 RARA NES
16 negative regulation of cartilage development GO:0061037 9.62 RARB RARA
17 glomerular visceral epithelial cell development GO:0072015 9.61 PODXL BMP4
18 growth plate cartilage development GO:0003417 9.61 RARB RARA
19 ureteric bud development GO:0001657 9.61 RARB RARA BMP4
20 multicellular organism development GO:0007275 9.61 SOX2 RARB RARA POU5F1 NES KIT
21 gland development GO:0048732 9.57 RARB RARA
22 lymphoid progenitor cell differentiation GO:0002320 9.56 KIT BMP4
23 cranial suture morphogenesis GO:0060363 9.54 FGF4 BMP4
24 chondroblast differentiation GO:0060591 9.51 RARA FGF4
25 embryonic hindlimb morphogenesis GO:0035116 9.5 RARB FGF4 BMP4
26 ventricular cardiac muscle cell differentiation GO:0055012 9.49 RARB RARA
27 endodermal cell fate specification GO:0001714 9.48 SOX2 POU5F1
28 somatic stem cell population maintenance GO:0035019 9.46 TDGF1 SOX2 POU5F1 KIT
29 outflow tract septum morphogenesis GO:0003148 9.43 RARB RARA BMP4
30 glandular epithelial cell development GO:0002068 9.4 RARB RARA
31 regulation of cell fate commitment GO:0010453 9.37 GDF3 BMP4
32 epithelium development GO:0060429 8.8 RARB RARA BMP4

Molecular functions related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region sequence-specific DNA binding GO:0000976 9.26 SOX2 RARB RARA POU5F1
2 transcription factor activity, direct ligand regulated sequence-specific DNA binding GO:0098531 9.16 RARB RARA
3 growth factor activity GO:0008083 8.92 TDGF1 GDF3 FGF4 BMP4

Sources for Embryonal Carcinoma

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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