MCID: EMB004
MIFTS: 58

Embryonal Carcinoma

Categories: Cancer diseases, Fetal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Embryonal Carcinoma

MalaCards integrated aliases for Embryonal Carcinoma:

Name: Embryonal Carcinoma 12 53 59 15 73
Embryonal Neoplasm 12 73
Embryonal Cancer 12 15
Primary Extragonadal Embryonal Carcinoma 12
Extragonadal Embryonal Carcinoma 73
Carcinoma, Embryonal 44
Carcinoma Embryonal 55
Cancer, Embryonal 73
Cancer Embryonal 55
Embryo Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3308 DOID:688
SNOMED-CT 68 28047004
Orphanet 59 ORPHA180226
ICD10 via Orphanet 34 C22.7 C71.9
MESH via Orphanet 45 D018236
UMLS via Orphanet 74 C0206659

Summaries for Embryonal Carcinoma

NIH Rare Diseases : 53 Embryonal carcinoma is a type of testicular cancer, which is cancer that starts in the testicles, the male reproductive glands located in the scrotum. It most often develops in young and middle-aged men. It tends to grow rapidly and spread outside the testicle. Embryonal carcinomas are classified as nonseminoma germ celltumors. Most testicular cancers grow from germ cells, the cells that make sperm. Germ cell tumors are broadly divided into seminomas and nonseminomas because each type has a different prognosis and treatment regimen. Nonseminomas, which are more common, tend to grow more quickly than seminomas. Nonseminoma tumors are often made up of more than one type of cell, and are identified according to the different cell types.

MalaCards based summary : Embryonal Carcinoma, also known as embryonal neoplasm, is related to ovarian embryonal carcinoma and intratubular embryonal carcinoma. An important gene associated with Embryonal Carcinoma is H19 (H19, Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways are Human Embryonic Stem Cell Pluripotency and Mesodermal Commitment Pathway. The drugs Paclitaxel and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and testis, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 An embryonal cancer that is a type of germ cell tumour that is located in the ovaries or located in the testes.

Wikipedia : 76 Embryonal carcinoma is a relatively uncommon type of germ cell tumour that occurs in the ovaries and... more...

Related Diseases for Embryonal Carcinoma

Diseases related to Embryonal Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 ovarian embryonal carcinoma 33.9 AFP POU5F1 SOX2 TNFRSF8
2 intratubular embryonal carcinoma 33.6 AFP KIT POU5F1 TNFRSF8
3 germ cell and embryonal cancer 33.6 AFP POU5F1 SOX2
4 embryonal testis carcinoma 33.5 AFP POU5F1
5 teratocarcinoma 33.0 FGF4 POU5F1 RARB TDGF1
6 embryoma 31.5 AFP KIT POU5F1 TNFRSF8
7 seminoma 30.6 AFP KIT POU5F1 TNFRSF8
8 teratoma 30.5 AFP KIT NES POU5F1 SOX2
9 mixed germ cell tumor 30.2 AFP KIT
10 malignant teratoma 29.9 AFP POU5F1
11 germ cell cancer 29.4 AFP FGF4 H19 KIT POU5F1 SOX2
12 childhood ovarian embryonal carcinoma 12.4
13 central nervous system embryonal carcinoma 12.2
14 adult central nervous system embryonal carcinoma 12.2
15 non-central nervous system-localized embryonal carcinoma 12.1
16 endodermal sinus tumor 11.9
17 testicular germ cell tumor 11.3
18 childhood embryonal testis carcinoma 11.3
19 childhood teratocarcinoma of the testis 11.1
20 pediatric cns embryonal cell carcinoma 11.1
21 polyembryoma 11.0
22 hemihyperplasia, isolated 10.9
23 kidney rhabdoid cancer 10.9
24 brain germinoma 10.3 AFP POU5F1
25 extragonadal germ cell cancer 10.3 AFP POU5F1
26 hepatic angiomyolipoma 10.3 AFP KIT
27 mixed cell type cancer 10.3 AFP KIT POU5F1
28 mixed germ cell-sex cord neoplasm 10.3 GATA4 KIT POU5F1
29 maturity-onset diabetes of the young, type 8, with exocrine dysfunction 10.3 POU5F1 SOX2
30 orbital cyst 10.2 GDF3 SOX2
31 endometrial small cell carcinoma 10.2 AFP KIT
32 mixed germ cell cancer 10.2 AFP POU5F1 TDGF1
33 physical disorder 10.2 AFP BMP4 TUBB3
34 ovarian solid teratoma 10.2 AFP TNFRSF8
35 sternum cancer 10.2 AFP TNFRSF8
36 venous hemangioma 10.2 POU5F1 SOX2
37 central nervous system cancer 10.2 NES SOX2 TUBB3
38 central nervous system germ cell tumor 10.2 AFP NES POU5F1 SOX2
39 conventional fibrosarcoma 10.2 KIT TNFRSF8
40 leukemia 10.2
41 germ cells tumors 10.2
42 rete testis adenocarcinoma 10.1 AFP KIT
43 aggressive systemic mastocytosis 10.1 H19 KIT
44 microphthalmia 10.1 BMP4 GDF3 KIT RARB SOX2
45 marek disease 10.1 H19 TNFRSF8
46 ovarian epithelial cancer 10.1 H19 HOTAIR
47 testicular infarct 10.1 AFP KIT POU5F1 TNFRSF8
48 malignant leydig cell tumor 10.1 KIT NES POU5F1 TNFRSF8
49 brain cancer 10.1 NES POU5F1 SOX2 TUBB3
50 gastric cardia adenocarcinoma 10.1 H19 HOTAIR

Graphical network of the top 20 diseases related to Embryonal Carcinoma:



Diseases related to Embryonal Carcinoma

Symptoms & Phenotypes for Embryonal Carcinoma

GenomeRNAi Phenotypes related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.4 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.4 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.4 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.4 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.4 POU5F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.4 AFP NDN POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.4 AFP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.4 POU5F1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.4 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.4 POU5F1

MGI Mouse Phenotypes related to Embryonal Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.26 BMP4 FGF4 GATA4 GDF3 KIT NDN
2 embryo MP:0005380 10.13 BMP4 FGF4 GATA4 GDF3 KIT POU5F1
3 mortality/aging MP:0010768 10.13 AFP BMP4 FGF4 GATA4 GDF3 KIT
4 endocrine/exocrine gland MP:0005379 10.06 AFP BMP4 GATA4 KIT POU5F1 RARB
5 digestive/alimentary MP:0005381 10 BMP4 GATA4 KIT POU5F1 RARB RARG
6 integument MP:0010771 9.97 BMP4 GATA4 KIT NDN POU5F1 RARG
7 nervous system MP:0003631 9.96 BMP4 GATA4 KIT NDN POU5F1 RARB
8 normal MP:0002873 9.9 BMP4 FGF4 GATA4 GDF3 KIT NDN
9 reproductive system MP:0005389 9.61 AFP BMP4 FGF4 GATA4 KIT POU5F1
10 respiratory system MP:0005388 9.28 BMP4 FGF4 GATA4 KIT NDN RARB

Drugs & Therapeutics for Embryonal Carcinoma

Drugs for Embryonal Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 95)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1 33069-62-4 36314
2
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
3
Bleomycin Approved, Investigational Phase 2, Phase 3,Phase 3 11056-06-7 5360373
4
Etoposide Approved Phase 2, Phase 3,Phase 3 33419-42-0 36462
5
Cisplatin Approved Phase 2, Phase 3,Phase 3,Phase 1 15663-27-1 2767 441203 84093
6
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 43805 6857599 5310940 9887054
7
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
8
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
9
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 6055-19-2, 50-18-0 2907
10
Captopril Approved Phase 3 62571-86-2 44093
11
Ribavirin Approved Phase 3 36791-04-5 37542
12
Palivizumab Approved, Investigational Phase 3 188039-54-5
13
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
14
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
15
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
16
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
17
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
18
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 38904 498142
19
Vinblastine Approved Phase 3 865-21-4 241903 13342
20 Albumin-Bound Paclitaxel Phase 2, Phase 3,Phase 3,Phase 1
21 Etoposide phosphate Phase 2, Phase 3,Phase 3
22 Antineoplastic Agents, Phytogenic Phase 2, Phase 3,Phase 3,Phase 1
23 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 3
24 Topoisomerase Inhibitors Phase 2, Phase 3,Phase 3
25 Antimitotic Agents Phase 2, Phase 3,Phase 3,Phase 1
26 Anti-Bacterial Agents Phase 2, Phase 3,Phase 3
27
Isophosphamide mustard Phase 3,Phase 1,Phase 2 0
28 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2
29 Alkylating Agents Phase 3,Phase 1,Phase 2
30 Immunologic Factors Phase 3,Phase 1,Phase 2
31 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
32 Antimetabolites Phase 3,Phase 1,Phase 2
33 Anti-Infective Agents Phase 3,Phase 1,Phase 2
34 Antiviral Agents Phase 3,Phase 1,Phase 2
35 Antihypertensive Agents Phase 3
36
protease inhibitors Phase 3
37 Antirheumatic Agents Phase 3
38 HIV Protease Inhibitors Phase 3
39 Angiotensin-Converting Enzyme Inhibitors Phase 3
40 Immunoglobulins Phase 3,Phase 2,Phase 1
41 Antibodies Phase 3,Phase 2,Phase 1
42 Antibodies, Monoclonal Phase 3,Phase 2,Phase 1
43 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
44 Cytochrome P-450 CYP3A Inhibitors Phase 3
45 Steroid Synthesis Inhibitors Phase 3
46 Cytochrome P-450 Enzyme Inhibitors Phase 3
47 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
48
Hydroxyitraconazole Phase 3
49 Hormones Phase 3,Phase 1,Phase 2
50 Antifungal Agents Phase 3

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
3 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
4 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
5 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
6 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
7 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
8 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
9 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
10 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
11 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
12 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
13 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
14 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
15 Brentuximab Vedotin (SGN-35) as Salvage Treatment for CD30-positive Germ Cell Tumors Completed NCT01851200 Phase 2 Brentuximab Vedotin
16 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
17 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
18 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
19 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
20 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
21 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
22 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
23 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
24 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
25 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
26 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
27 Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
28 Brentuximab Vedotin in Relapsed/Refractory Germ Cell Tumors Recruiting NCT02689219 Phase 2 Brentuximab Vedotin
29 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
30 MEN-10755 in Treating Patients With Solid Tumors Completed NCT00003982 Phase 1 sabarubicin
31 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
32 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
33 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
34 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Completed NCT01434355
35 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021 Not Applicable
36 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465 Not Applicable
37 Positron Emission Tomography in Detecting Testicle Cancer Completed NCT00045045 Not Applicable
38 Diagnostic Study of Patients With Stage I Testicular Cancer Completed NCT00003800 Not Applicable
39 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Completed NCT01080521

Search NIH Clinical Center for Embryonal Carcinoma

Cochrane evidence based reviews: carcinoma, embryonal

Genetic Tests for Embryonal Carcinoma

Anatomical Context for Embryonal Carcinoma

MalaCards organs/tissues related to Embryonal Carcinoma:

41
Ovary, Testes, Testis, Bone, Bone Marrow, Brain, Endothelial

The Foundational Model of Anatomy Ontology organs/tissues related to Embryonal Carcinoma:

19
The Ovaries Or

Publications for Embryonal Carcinoma

Articles related to Embryonal Carcinoma:

(show top 50) (show all 1048)
# Title Authors Year
1
DNA methylation of the Oct4A enhancers in embryonal carcinoma cells after etoposide treatment is associated with alternative splicing and altered pluripotency in reversibly senescent cells. ( 29372665 )
2018
2
Clinical Outcome of Retroperitoneal Lymph Node Dissection after Chemotherapy in Patients with Pure Embryonal Carcinoma in the Orchiectomy Specimen. ( 29410311 )
2018
3
Nuclear factor erythroid-2-related factor regulates LRWD1 expression and cellular adaptation to oxidative stress in human embryonal carcinoma cells. ( 29544732 )
2018
4
Delayed male germ cell sex-specification permits transition into embryonal carcinoma cells with features of primed pluripotency. ( 29545285 )
2018
5
The combined effects of three dimensional cell culture and natural tissue extract on neural differentiation of P19 embryonal carcinoma stem cells. ( 29905008 )
2018
6
The expression of the embryonic gene Cripto-1 is regulated by OCT4 in human embryonal carcinoma NCCIT cells. ( 29223130 )
2018
7
Mature Testicular Teratoma with a Focus of Embryonal Carcinoma: A Case Report and Review of Literature. ( 29770282 )
2018
8
Imsnc761 and DDX6 synergistically suppress cell proliferation and promote apoptosis via p53 in testicular embryonal carcinoma cells. ( 29769412 )
2018
9
Analysis of the Paternally-Imprinted DLK1-MEG3 and IGF2-H19 Tandem Gene Loci in NT2 Embryonal Carcinoma Cells Identifies DLK1 as a Potential Therapeutic Target. ( 29980981 )
2018
10
Directed differentiation of mouse P19 embryonal carcinoma cells to neural cells in a serum- and retinoic acid-free culture medium. ( 30030768 )
2018
11
CD30-Redirected Chimeric Antigen Receptor T Cells Target CD30+ and CD30- Embryonal Carcinoma via Antigen-Dependent and Fas/FasL Interactions. ( 30087115 )
2018
12
Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells. ( 30250195 )
2018
13
Malignant mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma harboring an EGFR mutation: a case report. ( 30349318 )
2018
14
Embryonal carcinoma presenting as a calcified solitary testicular mass on ultrasound. ( 28765489 )
2017
15
Brentuximab-vedotin maintenance following chemotherapy without irradiation for primary intracranial embryonal carcinoma in down syndrome. ( 29236132 )
2017
16
Distinct retinoic acid receptor (RAR) isotypes control differentiation of embryonal carcinoma cells to dopaminergic or striatopallidal medium spiny neurons. ( 29057906 )
2017
17
Embryonal Carcinoma with Immature Teratoma: A Homeopathic Case Report. ( 29080895 )
2017
18
Endobronchial Embryonal Carcinoma. ( 28323728 )
2017
19
Ovarian Embryonal Carcinoma in a Dog. ( 29169625 )
2017
20
Hsa-miR-513b-5p suppresses cell proliferation and promotes P53 expression by targeting IRF2 in testicular embryonal carcinoma cells. ( 28512062 )
2017
21
Mechanisms Regulating Stemness and Differentiation in Embryonal Carcinoma Cells. ( 28373885 )
2017
22
A Rare Case of Embryonal Carcinoma in a Patient with Turner Syndrome without Y Chromosomal Material but Mutations in KIT, AKT1, and ZNF358 Demonstrated Using Exome Sequencing. ( 29197878 )
2017
23
2102Ep embryonal carcinoma cells have compromised respiration and shifted bioenergetic profile distinct from H9 human embryonic stem cells. ( 28552560 )
2017
24
MyD88 is an essential component of retinoic acid-induced differentiation in human pluripotent embryonal carcinoma cells. ( 28885616 )
2017
25
In vitro induction of human embryonal carcinoma differentiation by a crude extract of Rhazya stricta. ( 28662725 )
2017
26
Increased expression of prion protein gene is accompanied by demethylation of CpG sites in a mouse embryonal carcinoma cell line, P19C6. ( 28132962 )
2017
27
Production of stable GFP-expressing neural cells from P19 embryonal carcinoma stem cells. ( 28013042 )
2016
28
Immature Teratoma with Embryonal Carcinoma; a Rare Malignant Mixed Germ Cell Tumor in a 13-Year-Old Girl. ( 26870146 )
2016
29
Non-Serotonergic Neurotoxicity by MDMA (Ecstasy) in Neurons Derived from Mouse P19 Embryonal Carcinoma Cells. ( 27861613 )
2016
30
Defining a New Prognostic Index for Stage I Nonseminomatous Germ Cell Tumors Using CXCL12 Expression and Proportion of Embryonal Carcinoma. ( 26453693 )
2016
31
Endobronchial Embryonal Carcinoma. ( 27623424 )
2016
32
SOX2 is essential for in vivo reprogramming of seminoma-like TCam-2 cells to an embryonal carcinoma-like fate. ( 27283990 )
2016
33
Autocrine glutamatergic transmission for the regulation of embryonal carcinoma stem cells. ( 27322683 )
2016
34
Testis peritubular myoid cells increase their motility and express matrix-metalloproteinase 9 (MMP-9) after interaction with embryonal carcinoma cells. ( 26711538 )
2016
35
Calmidazolium chloride inhibits growth of murine embryonal carcinoma cells, a model of cancer stem-like cells. ( 27247146 )
2016
36
Case report: Malignant germ cell tumour with predominant embryonal carcinoma component in a dysgenetic gonad. ( 27773100 )
2016
37
MicroRNA-29c overexpression inhibits proliferation and promotes apoptosis and differentiation in P19 embryonal carcinoma cells. ( 26484393 )
2016
38
Differentiation of P19 embryonal carcinoma stem cells into insulin-producing cells promoted by pancreas-conditioned medium. ( 25044225 )
2016
39
Primary pure and nonsecreting embryonal carcinoma of the anterior third ventricle: a case report. ( 25832366 )
2015
40
Aggressive multimodal therapy may prolong disease-free survival in recurrent primary retroperitoneal embryonal carcinoma. ( 25799960 )
2015
41
Downregulation of miR-320a/383-sponge-like long non-coding RNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation. ( 26539909 )
2015
42
BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma. ( 26226633 )
2015
43
Metastatic embryonal carcinoma mimicking locally advanced non-small cell lung cancer. ( 25742895 )
2015
44
Transcription factor NF-Y inhibits cell growth and decreases SOX2 expression in human embryonal carcinoma cell line NT2/D1. ( 25756534 )
2015
45
Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide. ( 26102294 )
2015
46
Pulmonary artery stenosis due to embryonal carcinoma with primary mediastinal location. ( 25754058 )
2015
47
Embryonal Carcinoma in Cryptorchid Abdominal Testis of an Infant. ( 26137335 )
2015
48
NgR1 Expressed in P19 Embryonal Carcinoma Cells Differentiated by Retinoic Acid Can Activate STAT3. ( 25729271 )
2015
49
The miR-134 attenuates the expression of transcription factor FOXM1 during pluripotent NT2/D1 embryonal carcinoma cell differentiation. ( 25447206 )
2015
50
Human embryonal carcinoma cells in serum-free conditions as an in vitro model system of neural differentiation. ( 25802994 )
2015

Variations for Embryonal Carcinoma

Expression for Embryonal Carcinoma

Search GEO for disease gene expression data for Embryonal Carcinoma.

Pathways for Embryonal Carcinoma

GO Terms for Embryonal Carcinoma

Cellular components related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor complex GO:0090575 8.8 GATA4 RARB RARG

Biological processes related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 BMP4 FGF4 KIT POU5F1 RARG
2 multicellular organism development GO:0007275 9.97 BMP4 FGF4 GDF3 NES POU5F1 RARB
3 positive regulation of cell migration GO:0030335 9.93 BMP4 KIT PODXL TDGF1
4 BMP signaling pathway GO:0030509 9.81 BMP4 GDF3 TDGF1
5 cell development GO:0048468 9.76 BMP4 GATA4 GDF3
6 SMAD protein signal transduction GO:0060395 9.74 AFP BMP4 GDF3
7 bone development GO:0060348 9.73 BMP4 RARB RARG
8 regulation of gene expression GO:0010468 9.72 BMP4 FGF4 POU5F1 RARG SOX2
9 steroid hormone mediated signaling pathway GO:0043401 9.7 BMP4 RARB RARG
10 regulation of myelination GO:0031641 9.67 RARB RARG
11 retinoic acid receptor signaling pathway GO:0048384 9.66 RARB RARG
12 cardiac right ventricle morphogenesis GO:0003215 9.65 BMP4 GATA4
13 embryonic camera-type eye development GO:0031076 9.65 NES RARG
14 endocardial cushion development GO:0003197 9.64 BMP4 GATA4
15 growth plate cartilage development GO:0003417 9.63 RARB RARG
16 negative regulation of cartilage development GO:0061037 9.62 RARB RARG
17 embryonic eye morphogenesis GO:0048048 9.62 RARB RARG
18 positive regulation of programmed cell death GO:0043068 9.61 RARB RARG
19 glomerular visceral epithelial cell development GO:0072015 9.61 BMP4 PODXL
20 endoderm development GO:0007492 9.61 BMP4 GATA4 GDF3
21 gland development GO:0048732 9.58 RARB RARG
22 cranial suture morphogenesis GO:0060363 9.55 BMP4 FGF4
23 lymphoid progenitor cell differentiation GO:0002320 9.54 BMP4 KIT
24 endodermal cell fate specification GO:0001714 9.51 POU5F1 SOX2
25 regulation of cell fate commitment GO:0010453 9.48 BMP4 GDF3
26 glandular epithelial cell development GO:0002068 9.46 RARB RARG
27 somatic stem cell population maintenance GO:0035019 9.46 KIT POU5F1 SOX2 TDGF1
28 negative regulation of chondrocyte differentiation GO:0032331 9.43 BMP4 RARB RARG
29 epithelium development GO:0060429 9.13 BMP4 RARB RARG
30 embryonic hindlimb morphogenesis GO:0035116 8.92 BMP4 FGF4 RARB RARG
31 negative regulation of apoptotic process GO:0043066 10.06 BMP4 FGF4 KIT RARB TDGF1
32 positive regulation of cell proliferation GO:0008284 10.05 BMP4 FGF4 KIT RARG TDGF1
33 cell differentiation GO:0030154 10.04 BMP4 FGF4 KIT RARB RARG SOX2
34 positive regulation of transcription by RNA polymerase II GO:0045944 10.01 BMP4 FGF4 GATA4 NDN POU5F1 RARB
35 negative regulation of cell proliferation GO:0008285 10 BMP4 NDN RARB RARG TNFRSF8

Molecular functions related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.72 GATA4 POU5F1 RARB RARG SOX2
2 growth factor activity GO:0008083 9.46 BMP4 FGF4 GDF3 TDGF1
3 retinoid X receptor binding GO:0046965 9.26 RARB RARG
4 retinoic acid receptor activity GO:0003708 8.96 RARB RARG
5 transcription regulatory region sequence-specific DNA binding GO:0000976 8.92 POU5F1 RARB RARG SOX2

Sources for Embryonal Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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