MCID: EMB004
MIFTS: 56

Embryonal Carcinoma

Categories: Cancer diseases, Fetal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Embryonal Carcinoma

MalaCards integrated aliases for Embryonal Carcinoma:

Name: Embryonal Carcinoma 12 20 58 15 17 71
Embryonal Neoplasm 12 17 71
Embryonal Cancer 12 15
Primary Extragonadal Embryonal Carcinoma 12
Extragonadal Embryonal Carcinoma 71
Carcinoma, Embryonal 44
Carcinoma Embryonal 54
Cancer, Embryonal 71
Cancer Embryonal 54
Embryo Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3308 DOID:688
SNOMED-CT 67 28047004
MESH via Orphanet 45 D018236
ICD10 via Orphanet 33 C22.7 C71.9
UMLS via Orphanet 72 C0206659
Orphanet 58 ORPHA180226
UMLS 71 C0027654 C0206659 C0751364 more

Summaries for Embryonal Carcinoma

GARD : 20 Embryonal carcinoma is a type of testicular cancer, which is cancer that starts in the testicles, the male reproductive glands located in the scrotum. It most often develops in young and middle-aged men. It tends to grow rapidly and spread outside the testicle. Embryonal carcinomas are classified as nonseminoma germ cell tumors. Most testicular cancers grow from germ cells, the cells that make sperm. Germ cell tumors are broadly divided into seminomas and nonseminomas because each type has a different prognosis and treatment regimen. Nonseminomas, which are more common, tend to grow more quickly than seminomas. Nonseminoma tumors are often made up of more than one type of cell, and are identified according to the different cell types.

MalaCards based summary : Embryonal Carcinoma, also known as embryonal neoplasm, is related to ovarian embryonal carcinoma and endodermal sinus tumor. An important gene associated with Embryonal Carcinoma is H19 (H19 Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways are ERK Signaling and Developmental Biology. The drugs Etoposide and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include ovaries, testes and testis, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 An embryonal cancer that is a type of germ cell tumour that is located in the ovaries or located in the testes.

Wikipedia : 74 Embryonal carcinoma is a relatively uncommon type of germ cell tumour that occurs in the ovaries and... more...

Related Diseases for Embryonal Carcinoma

Diseases related to Embryonal Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 219)
# Related Disease Score Top Affiliating Genes
1 ovarian embryonal carcinoma 32.9 TNFRSF8 POU5F1 AFP
2 endodermal sinus tumor 32.4 TNFRSF8 MIR302A AFP
3 intratubular embryonal carcinoma 32.3 TNFRSF8 POU5F1 KIT AFP
4 teratocarcinoma 32.3 TDGF1 RARB RARA POU5F1 MIR302A GDF3
5 germ cell and embryonal cancer 31.5 TDGF1 SOX2 POU5F1 NES MIR302A KIT
6 teratoma 31.4 SOX2 POU5F1 NES KIT AFP
7 mixed germ cell tumor 31.2 KIT AFP
8 seminoma 31.2 TNFRSF8 SOX2 POU5F1 KIT AFP
9 mature teratoma 30.5 TNFRSF8 POU5F1 MIR302A KIT AFP
10 brain germinoma 30.5 POU5F1 KIT ESRG AFP
11 germinoma 30.4 POU5F1 MIR302A KIT ESRG AFP
12 malignant teratoma 30.4 TNFRSF8 SOX2 POU5F1 KIT AFP
13 mediastinum seminoma 30.4 KIT AFP
14 central nervous system germinoma 30.4 POU5F1 MIR302A
15 dysgerminoma of ovary 30.4 POU5F1 KIT AFP
16 ovarian mixed germ cell neoplasm 30.3 KIT AFP
17 germ cell cancer 30.0 SOX2 POU5F1 NES MIR302A KIT H19
18 neuroblastoma 29.8 SOX2 POU5F1 NES KIT HOTAIR H19
19 medulloblastoma 29.4 SOX2 POU5F1 NES KIT HOTAIR H19
20 embryonal testis carcinoma 11.6
21 childhood ovarian embryonal carcinoma 11.5
22 central nervous system embryonal carcinoma 11.4
23 testicular germ cell tumor 11.4
24 childhood embryonal testis carcinoma 11.3
25 adult central nervous system embryonal carcinoma 11.3
26 pediatric cns embryonal cell carcinoma 11.2
27 non-central nervous system-localized embryonal carcinoma 11.2
28 polyembryoma 11.1
29 childhood teratocarcinoma of the testis 11.0
30 kidney rhabdoid cancer 11.0
31 germ cells tumors 10.7
32 pediatric testicular germ cell tumor 10.5 POU5F1 AFP
33 testicular yolk sac tumor 10.5
34 testicular cancer 10.5
35 liver lymphoma 10.5 FGF4 AFP
36 extragonadal seminoma 10.5 KIT AFP
37 ovarian primitive germ cell tumor 10.5 POU5F1 AFP
38 choriocarcinoma 10.5
39 ovarian endodermal sinus tumor 10.5 POU5F1 AFP
40 pineal region teratoma 10.5 KIT AFP
41 gallbladder leiomyosarcoma 10.4 KIT AFP
42 keratomalacia 10.4 RARS1 RARB RARA
43 spermatocytoma 10.4 POU5F1 KIT AFP
44 liver leiomyoma 10.4 KIT AFP
45 esophageal adenoid cystic carcinoma 10.4 KIT AFP
46 tyrosinemia 10.4 SOX2 POU5F1 AFP
47 central nervous system immature teratoma 10.4 SOX2 NES
48 central nervous system germ cell tumor 10.4 POU5F1 AFP
49 sarcomatous intrahepatic cholangiocarcinoma 10.4 KIT AFP
50 endometrial small cell carcinoma 10.4 KIT AFP

Graphical network of the top 20 diseases related to Embryonal Carcinoma:



Diseases related to Embryonal Carcinoma

Symptoms & Phenotypes for Embryonal Carcinoma

GenomeRNAi Phenotypes related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.28 NDN
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-114 9.28 AFP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 9.28 AFP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.28 NDN
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.28 AFP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.28 AFP
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.28 AFP
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.28 AFP NDN

MGI Mouse Phenotypes related to Embryonal Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.17 BMP4 FGF4 GDF3 KIT NDN POU5F1
2 embryo MP:0005380 10.07 BMP4 FGF4 GDF3 KIT POU5F1 RARA
3 endocrine/exocrine gland MP:0005379 9.97 AFP BMP4 KIT POU5F1 RARA RARB
4 digestive/alimentary MP:0005381 9.95 BMP4 KIT POU5F1 RARA RARB RARG
5 normal MP:0002873 9.9 BMP4 FGF4 GDF3 KIT NDN POU5F1
6 hearing/vestibular/ear MP:0005377 9.73 BMP4 KIT RARA RARB RARG SOX2
7 reproductive system MP:0005389 9.61 AFP BMP4 FGF4 KIT POU5F1 RARA
8 respiratory system MP:0005388 9.23 BMP4 FGF4 KIT NDN RARA RARB

Drugs & Therapeutics for Embryonal Carcinoma

Drugs for Embryonal Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 3 33419-42-0 36462
2
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
3
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
4
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
5 Etoposide phosphate Phase 3
6 Antibiotics, Antitubercular Phase 3
7 Anti-Bacterial Agents Phase 3
8 Keratolytic Agents Phase 3
9 Tubulin Modulators Phase 3
10 Dermatologic Agents Phase 3
11 Antimitotic Agents Phase 3
12 Podophyllotoxin Phase 3 518-28-5
13
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
14
Melphalan Approved Phase 1, Phase 2 148-82-3 4053 460612
15
Mannitol Approved, Investigational Phase 1, Phase 2 69-65-8 453 6251
16
Mesna Approved, Investigational Phase 2 3375-50-6 598
17
Levonorgestrel Approved, Investigational Phase 2 797-63-7, 17489-40-6 13109
18
Lenograstim Approved, Investigational Phase 2 135968-09-1
19
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
20
Ifosfamide Approved Phase 2 3778-73-2 3690
21
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
22
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
23
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
24
Phenylalanine Approved, Investigational, Nutraceutical Phase 1, Phase 2 63-91-2 6140
25 Molgramostim Investigational Phase 2 99283-10-0
26 Albumin-Bound Paclitaxel Phase 2
27 sodium thiosulfate Phase 1, Phase 2
28 diuretics Phase 1, Phase 2
29 Anti-Infective Agents Phase 1, Phase 2
30 Antitubercular Agents Phase 1, Phase 2
31 Antioxidants Phase 1, Phase 2
32 Nitrogen Mustard Compounds Phase 1, Phase 2
33 Chelating Agents Phase 1, Phase 2
34 Antidotes Phase 1, Phase 2
35 Protective Agents Phase 2
36 Immunosuppressive Agents Phase 2
37 Immunologic Factors Phase 2
38 Adjuvants, Immunologic Phase 2
39
Isophosphamide mustard Phase 2 100427
40 Alkylating Agents Phase 2
41
L-Alanine Nutraceutical Phase 1, Phase 2 56-41-7 5950
42
Ipilimumab Approved Phase 1 477202-00-9
43 Antineoplastic Agents, Immunological Phase 1
44 Immunoglobulins Phase 1
45 Antibodies Phase 1
46 Antibodies, Monoclonal Phase 1
47 Immunoglobulins, Intravenous Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase III Study Of Reduced Therapy In The Treatment Of Children With Low And Intermediate Risk Extracranial Germ Cell Tumors Unknown status NCT00053352 Phase 3 cisplatin;etoposide
2 A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide;Etoposide Phosphate
3 Treatment of Recurrent or Resistant Pediatric Malignant Germ Cell Tumors With Paclitaxel, Ifosfamide and Carboplatin Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
4 Phase I/II Study of Intra-Arterial Melphalan Given With Intra-Arterial Carboplatin, Osmotic Blood-Brain Barrier Disruption and Delayed Otoprotective Sodium Thiosulfate for Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Recruiting NCT00983398 Phase 1, Phase 2 Carboplatin;Mannitol;Melphalan;Sodium Thiosulfate
5 A Phase 2 Trial of Chemotherapy Followed by Response-Based Whole Ventricular &Amp; Spinal Canal Irradiation (WVSCI) for Patients With Localized Non-Germinomatous Central Nervous System Germ Cell Tumor Not yet recruiting NCT04684368 Phase 2 Carboplatin;Etoposide;Ifosfamide;Mesna;Thiotepa
6 A Multicenter Phase II Study of Brentuximab Vedotin in Relapsed/Refractory Germ Cell Tumors Terminated NCT02689219 Phase 2 Brentuximab Vedotin
7 CTLA-4 Blockade With MDX-010 to Induce Graft-Versus-Malignancy Effects Following Allogeneic Hematopoietic Stem Cell Transplantation Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
8 A Prospective Study of Cognitive Function During Chemotherapy for Front-Line Treatment of Ovarian, Primary Peritoneal or Fallopian Tube Cancer Completed NCT01080521
9 Molecular Epidemiology of Pediatric Germ Cell Tumors Completed NCT01434355
10 Gene Expression Profiling of Infant Embryonal Central Nervous System Tumors by Microarray Gene Chip Analysis: Angiogenesis, Invasion and Metastasis Completed NCT00010114

Search NIH Clinical Center for Embryonal Carcinoma

Cochrane evidence based reviews: carcinoma, embryonal

Genetic Tests for Embryonal Carcinoma

Anatomical Context for Embryonal Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Embryonal Carcinoma:

19
Ovaries, Testes

MalaCards organs/tissues related to Embryonal Carcinoma:

40
Testis, Testes, Brain, Liver, Lymph Node, Ovary, Pineal

Publications for Embryonal Carcinoma

Articles related to Embryonal Carcinoma:

(show top 50) (show all 4219)
# Title Authors PMID Year
1
Alpha-fetoprotein-producing non-germ cell tumours of the female genital tract. 54 61
20185298 2010
2
Expression of embryonic stem cell markers in cultured JKT-1, a cell line derived from a human seminoma. 61 54
19226408 2010
3
Analysis of SOX2 expression in developing human testis and germ cell neoplasia. 61 54
19876845 2010
4
Reprogramming of Xist against the pluripotent state in fusion hybrids. 61 54
19843582 2009
5
Tumour microvessel endothelial cell KIT and stem cell factor expression in human solid tumours. 61 54
19912360 2009
6
Necdin: a multi functional protein with potential tumor suppressor role? 61 54
19626646 2009
7
The role of promoter CpG methylation in the epigenetic control of stem cell related genes during differentiation. 54 61
19221495 2009
8
Midkine translocated to nucleoli and involved in carcinogenesis. 54 61
19152444 2009
9
miR-302b maintains "stemness" of human embryonal carcinoma cells by post-transcriptional regulation of Cyclin D2 expression. 54 61
18930031 2008
10
Expression of RALDHs (ALDH1As) and CYP26s in human tissues and during the neural differentiation of P19 embryonal carcinoma stem cell. 61 54
18502188 2008
11
Regulation of human Cripto-1 gene expression by TGF-beta1 and BMP-4 in embryonal and colon cancer cells. 61 54
17941089 2008
12
Nestin expression in central nervous system germ cell tumors. 61 54
18092184 2008
13
Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. 61 54
18045648 2008
14
Dynamic and selective interactions of the transcriptional corepressor TIF1 beta with the heterochromatin protein HP1 isotypes during cell differentiation. 54 61
17381543 2007
15
Testicular maturation arrest to testis cancer: spectrum of expression of the vitamin D receptor and vitamin D treatment in vitro. 61 54
17644135 2007
16
Selective repression of retinoic acid target genes by RIP140 during induced tumor cell differentiation of pluripotent human embryonal carcinoma cells. 54 61
17880687 2007
17
Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells. 54 61
17663992 2007
18
Transcriptional regulation of human Oct4 by steroidogenic factor-1. 61 54
17226773 2007
19
[Malignant ovarian germ cell tumours: a trial of 36 cases]. 61 54
17350873 2007
20
Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract. 54 61
17314394 2007
21
Q2ChIP, a quick and quantitative chromatin immunoprecipitation assay, unravels epigenetic dynamics of developmentally regulated genes in human carcinoma cells. 61 54
17272500 2007
22
Nestin is expressed in the basal/myoepithelial layer of the mammary gland and is a selective marker of basal epithelial breast tumors. 54 61
17234757 2007
23
Elevating the levels of Sox2 in embryonal carcinoma cells and embryonic stem cells inhibits the expression of Sox2:Oct-3/4 target genes. 61 54
17324942 2007
24
OCT4: biological functions and clinical applications as a marker of germ cell neoplasia. 54 61
17117392 2007
25
Oncofetal protein glypican-3 in testicular germ-cell tumor. 54 61
16896894 2006
26
Differential activity of the FGF-4 enhancer in F9 and P19 embryonal carcinoma cells. 61 54
16523502 2006
27
Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. 54 61
16793513 2006
28
OAZ regulates bone morphogenetic protein signaling through Smad6 activation. 61 54
16373339 2006
29
Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors. 61 54
16424014 2006
30
The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation. 54 61
16344469 2005
31
CD30 (Ki-1) molecule expression in human embryonal epithelial cells of the basal layer of the developing epidermis and epidermal buds and its potential significance for embryogenesis. 54 61
16200333 2005
32
Differentiation of human embryonal carcinomas in vitro and in vivo reveals expression profiles relevant to normal development. 61 54
15994931 2005
33
Distal enhancer of the mouse FGF-4 gene and its human counterpart exhibit differential activity: critical role of a GT box. 54 61
15803454 2005
34
Targeted inhibition of the transcription factor YY1 in an embryonal carcinoma cell line results in retarded cell growth, elevated levels of p53 but no increase in apoptotic cell death. 61 54
16003908 2005
35
Overexpression of anti-apoptotic Mcl-1 in testicular germ cell tumours. 61 54
15842635 2005
36
OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma. 61 54
15725806 2005
37
NF-Y behaves as a bifunctional transcription factor that can stimulate or repress the FGF-4 promoter in an enhancer-dependent manner. 54 61
16128003 2005
38
Retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells is potentiated by leukemia inhibitory factor. 54 61
15641927 2005
39
Human embryonal epithelial cells of the developing small intestinal crypts can express the Hodgkin-cell associated antigen Ki-1 (CD30) in spontaneous abortions during the first trimester of gestation. 61 54
15644135 2005
40
Sox7 plays crucial roles in parietal endoderm differentiation in F9 embryonal carcinoma cells through regulating Gata-4 and Gata-6 expression. 61 54
15542856 2004
41
Oncogenic role of NALP7 in testicular seminomas. 61 54
15596043 2004
42
Transcription factor Sox-2 inhibits co-activator stimulated transcription. 61 54
15349837 2004
43
Association of the transcriptional corepressor TIF1beta with heterochromatin protein 1 (HP1): an essential role for progression through differentiation. 61 54
15342492 2004
44
Necdin interacts with the Msx2 homeodomain protein via MAGE-D1 to promote myogenic differentiation of C2C12 cells. 54 61
15272023 2004
45
Receptor interacting protein 140 as a thyroid hormone-dependent, negative co-regulator for the induction of cellular retinoic acid binding protein I gene. 61 54
15130509 2004
46
Specific knockdown of Oct4 and beta2-microglobulin expression by RNA interference in human embryonic stem cells and embryonic carcinoma cells. 54 61
15342930 2004
47
Negative feedback at the level of nuclear receptor coregulation. Self-limitation of retinoid signaling by RIP140. 61 54
14506269 2003
48
Oct-4-expressing cells in human amniotic fluid: a new source for stem cell research? 61 54
12832377 2003
49
p27 and cyclin E/D2 associations in testicular germ cell tumors: implications for tumorigenesis. 61 54
12777997 2003
50
Islet cell hyperplasia in transgenic mice overexpressing EAT/mcl-1, a bcl-2 related gene. 54 61
12782407 2003

Variations for Embryonal Carcinoma

Cosmic variations for Embryonal Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM88315457 KIT ovary,NS,germ cell tumour,embryonal carcinoma c.1965T>A p.N655K 4:54728096-54728096 0
2 COSM133536937 AKT1 ovary,NS,germ cell tumour,embryonal carcinoma c.967G>A p.D323N 14:104773083-104773083 0
3 COSM105585949 AKT1 ovary,NS,germ cell tumour,embryonal carcinoma c.967G>A p.D323N 14:104773083-104773083 0
4 COSM134536549 AKT1 ovary,NS,germ cell tumour,embryonal carcinoma c.967G>A p.D323N 14:104773083-104773083 0
5 COSM103843275 AKT1 ovary,NS,germ cell tumour,embryonal carcinoma c.967G>A p.D323N 14:104773083-104773083 0
6 COSM89234463 AKT1 ovary,NS,germ cell tumour,embryonal carcinoma c.967G>A p.D323N 14:104773083-104773083 0
7 COSM136350617 AKT1 ovary,NS,germ cell tumour,embryonal carcinoma c.967G>A p.D323N 14:104773083-104773083 0

Expression for Embryonal Carcinoma

Search GEO for disease gene expression data for Embryonal Carcinoma.

Pathways for Embryonal Carcinoma

Pathways related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 TNFRSF8 TDGF1 SOX2 RARG RARB RARA
2
Show member pathways
13.37 TDGF1 SOX2 RARG RARB RARA POU5F1
3 12.71 RARB RARA KIT FGF4 BMP4
4
Show member pathways
12.3 TDGF1 SOX2 POU5F1 FGF4 BMP4
5
Show member pathways
12.11 SOX2 RARG RARB POU5F1 GDF3 BMP4
6 11.98 TDGF1 SOX2 POU5F1 BMP4 AFP
7
Show member pathways
11.72 RARG RARB RARA
8 11.71 TDGF1 KIT FGF4 BMP4
9 11.6 SOX2 NES FGF4 BMP4
10
Show member pathways
11.56 RARG RARB RARA
11 11.5 SOX2 POU5F1 MIR302A
12
Show member pathways
11.4 TDGF1 SOX2 POU5F1
13 11.38 KIT FGF4 BMP4
14 11.36 RARG RARB RARA
15 11.31 RARG RARB RARA
16 11.29 SOX2 POU5F1 PODXL NES FGF4 BMP4
17 11.28 SOX2 POU5F1 KIT BMP4
18 11.2 RARG RARB RARA
19 10.77 SOX2 POU5F1 FGF4
20
Show member pathways
10.13 SOX2 POU5F1 BMP4

GO Terms for Embryonal Carcinoma

Cellular components related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.47 TNFRSF8 SOX2 RARS1 RARG RARB RARA

Biological processes related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 10.19 SOX2 POU5F1 NES KIT GDF3 FGF4
2 cell differentiation GO:0030154 10.15 TDGF1 SOX2 RARG RARB RARA FGF4
3 negative regulation of transcription by RNA polymerase II GO:0000122 10.11 SOX2 RARG RARB RARA POU5F1 NDN
4 positive regulation of transcription by RNA polymerase II GO:0045944 10.11 SOX2 RARG RARB RARA POU5F1 NDN
5 negative regulation of apoptotic process GO:0043066 10.07 TDGF1 RARB RARA FGF4 BMP4
6 positive regulation of cell proliferation GO:0008284 10.05 TDGF1 RARG RARA KIT FGF4 BMP4
7 positive regulation of gene expression GO:0010628 10.02 RARG RARA POU5F1 KIT FGF4 BMP4
8 regulation of gene expression GO:0010468 10 SOX2 RARG POU5F1 FGF4 BMP4
9 positive regulation of cell migration GO:0030335 9.97 TDGF1 PODXL KIT BMP4
10 negative regulation of cell proliferation GO:0008285 9.97 TNFRSF8 RARG RARB RARA NDN BMP4
11 positive regulation of neuron differentiation GO:0045666 9.85 RARB RARA BMP4
12 neural tube closure GO:0001843 9.85 RARG RARA BMP4
13 multicellular organism growth GO:0035264 9.84 RARG RARB RARA
14 SMAD protein signal transduction GO:0060395 9.83 GDF3 BMP4 AFP
15 hormone-mediated signaling pathway GO:0009755 9.8 RARG RARB RARA
16 ureteric bud development GO:0001657 9.76 RARB RARA BMP4
17 outflow tract septum morphogenesis GO:0003148 9.71 RARB RARA BMP4
18 somatic stem cell population maintenance GO:0035019 9.71 TDGF1 SOX2 POU5F1 KIT
19 face development GO:0060324 9.69 RARG RARA
20 positive regulation of SMAD protein signal transduction GO:0060391 9.68 POU5F1 BMP4
21 negative regulation of pri-miRNA transcription by RNA polymerase II GO:1902894 9.68 POU5F1 BMP4
22 positive regulation of programmed cell death GO:0043068 9.67 RARG RARB
23 bone development GO:0060348 9.67 RARG RARB RARA BMP4
24 glomerular visceral epithelial cell development GO:0072015 9.66 PODXL BMP4
25 embryonic eye morphogenesis GO:0048048 9.65 RARG RARB
26 regulation of myelination GO:0031641 9.65 RARG RARB RARA
27 epithelium development GO:0060429 9.64 RARG BMP4
28 lymphoid progenitor cell differentiation GO:0002320 9.64 KIT BMP4
29 cranial suture morphogenesis GO:0060363 9.63 FGF4 BMP4
30 negative regulation of chondrocyte differentiation GO:0032331 9.63 RARG RARB BMP4
31 chondroblast differentiation GO:0060591 9.62 RARA FGF4
32 ventricular cardiac muscle cell differentiation GO:0055012 9.62 RARB RARA
33 endodermal cell fate specification GO:0001714 9.61 SOX2 POU5F1
34 retinoic acid receptor signaling pathway GO:0048384 9.61 RARG RARB RARA
35 trachea cartilage development GO:0060534 9.59 RARG RARA
36 BMP signaling pathway involved in heart induction GO:0003130 9.56 POU5F1 BMP4
37 regulation of cell fate commitment GO:0010453 9.52 GDF3 BMP4
38 embryonic camera-type eye development GO:0031076 9.5 RARG RARA NES
39 negative regulation of cartilage development GO:0061037 9.43 RARG RARB RARA
40 growth plate cartilage development GO:0003417 9.33 RARG RARB RARA
41 embryonic hindlimb morphogenesis GO:0035116 9.26 RARG RARB FGF4 BMP4
42 glandular epithelial cell development GO:0002068 8.8 RARG RARB RARA

Molecular functions related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.55 SOX2 RARG RARB RARA POU5F1
2 retinoid X receptor binding GO:0046965 9.26 RARG RARB
3 nuclear receptor activity GO:0004879 9.13 RARG RARB RARA
4 growth factor activity GO:0008083 8.92 TDGF1 GDF3 FGF4 BMP4

Sources for Embryonal Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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