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MCID: EMB004
MIFTS: 55

Embryonal Carcinoma

Categories: Cancer diseases, Fetal diseases, Rare diseases, Reproductive diseases
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Genes Variations Tissues Related diseases Publications Drugs
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Aliases & Classifications for Embryonal Carcinoma

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MalaCards integrated aliases for Embryonal Carcinoma:

Name: Embryonal Carcinoma 11 19 58 14 16 71 75
Embryonal Neoplasm 11 16 71
Embryonal Cancer 11 14
Primary Extragonadal Embryonal Carcinoma 11
Extragonadal Embryonal Carcinoma 71
Carcinoma, Embryonal 43
Carcinoma Embryonal 53
Cancer, Embryonal 71
Cancer Embryonal 53
Embryo Neoplasm 11

Characteristics:


Prevelance:

<1/1000000 (Europe) 58

Age Of Onset:

Adolescent,Childhood 58

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases Fetal diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 11 DOID:3308 DOID:688
SNOMED-CT 68 1156454002
MESH via Orphanet 44 D018236
ICD10 via Orphanet 32 C22.7 C71.9
UMLS via Orphanet 72 C0206659
Orphanet 58 ORPHA180226
UMLS 71 C0027654 C0206659 C0751364 more
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Summaries for Embryonal Carcinoma

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GARD: 19 Embryonal carcinoma is a type of testicular cancer, which is cancer that starts in the testicles, the male reproductive glands located in the scrotum. It most often develops in young and middle-aged men. It tends to grow rapidly and spread outside the testicle. Embryonal carcinomas are classified as nonseminoma germ cell tumors. Most testicular cancers grow from germ cells, the cells that make sperm. Germ cell tumors are broadly divided into seminomas and nonseminomas because each type has a different prognosis and treatment regimen. Nonseminomas, which are more common, tend to grow more quickly than seminomas. Nonseminoma tumors are often made up of more than one type of cell, and are identified according to the different cell types.

MalaCards based summary: Embryonal Carcinoma, also known as embryonal neoplasm, is related to ovarian embryonal carcinoma and teratocarcinoma. An important gene associated with Embryonal Carcinoma is H19 (H19 Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways are ERK Signaling and Nanog in Mammalian ESC Pluripotency. The drugs Cisplatin and Bleomycin have been mentioned in the context of this disorder. Affiliated tissues include ovaries, testes and brain, and related phenotypes are normal and endocrine/exocrine gland

Disease Ontology 11 Embryonal carcinoma: An embryonal cancer that is a type of germ cell tumour that is located in the ovaries or located in the testes.

Embryonal cancer: A germ cell cancer that is associated with an embryo.

Wikipedia: 75 Embryonal carcinoma is a relatively uncommon type of germ cell tumour that occurs in the ovaries and... more...
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Related Diseases for Embryonal Carcinoma

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Diseases related to Embryonal Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 280)
# Related Disease Score Top Affiliating Genes
1 ovarian embryonal carcinoma 32.7 TNFRSF8 SOX2 POU5F1 AFP
2 teratocarcinoma 32.5 TDGF1 RARS1 RARB RARA POU5F1 NR6A1
3 endodermal sinus tumor 32.4 TNFRSF8 POU5F1 KIT AFP
4 intratubular embryonal carcinoma 32.2 TNFRSF8 POU5F1 KIT AFP
5 germ cell and embryonal cancer 31.7 TDGF1 SOX2 POU5F1 NES MIR302B KIT
6 testicular cancer 31.1 TNFRSF8 POU5F1 KIT AFP
7 teratoma 31.1 SOX2 POU5F1 NES KIT H19 AFP
8 testicular germ cell cancer 31.0 POU5F1 KIT GDF3 AFP
9 seminoma 31.0 TNFRSF8 SOX2 POU5F1 KIT AFP
10 germ cell cancer 31.0 TNFRSF8 TDGF1 SOX2 POU5F1 NES MIR302B
11 gonadoblastoma 30.8 POU5F1 KIT AFP
12 keratomalacia 30.8 RARS1 RARB RARA
13 malignant teratoma 30.6 TNFRSF8 SOX2 POU5F1 KIT AFP
14 mixed germ cell cancer 30.6 TNFRSF8 SOX2 POU5F1 KIT GDF3 AFP
15 ovarian germ cell cancer 30.5 POU5F1 KIT AFP
16 mature teratoma 30.5 TNFRSF8 SOX2 POU5F1 KIT AFP
17 mediastinum seminoma 30.3 KIT AFP
18 rhabdomyosarcoma 30.2 RARB RARA NES KIT H19 BMP4
19 germinoma 30.2 POU5F1 KIT ESRG AFP
20 wilms tumor 1 30.0 SOX2 POU5F1 PODXL KIT H19 AFP
21 ewing sarcoma 30.0 TNFRSF8 POU5F1 NES KIT
22 mediastinal cancer 30.0 TNFRSF8 KIT AFP
23 dysgerminoma of ovary 29.9 TNFRSF8 POU5F1 KIT AFP
24 neuroblastoma 29.9 SOX2 POU5F1 NES KIT HOTAIR H19
25 brain germinoma 29.9 POU5F1 KIT ESRG AFP
26 medulloblastoma 29.4 SOX2 POU5F1 NES KIT HOTAIR H19
27 embryonal testis carcinoma 11.6
28 testicular germ cell tumor 11.6
29 childhood ovarian embryonal carcinoma 11.5
30 central nervous system embryonal carcinoma 11.5
31 childhood embryonal testis carcinoma 11.3
32 adult central nervous system embryonal carcinoma 11.3
33 polyembryoma 11.2
34 childhood cns embryonal cell carcinoma 11.2
35 non-central nervous system-localized embryonal carcinoma 11.2
36 childhood teratocarcinoma of the testis 11.1
37 malignant non-dysgerminomatous germ cell tumor of ovary 11.0
38 kidney rhabdoid cancer 11.0
39 germ cell tumor 10.7
40 choriocarcinoma 10.5
41 childhood testicular germ cell tumor 10.4 POU5F1 AFP
42 ovarian endodermal sinus tumor 10.4 POU5F1 AFP
43 childhood endodermal sinus tumor 10.4 GDF3 AFP
44 ovarian primitive germ cell tumor 10.4 POU5F1 AFP
45 pigmented villonodular synovitis 10.4
46 tenosynovial giant cell tumor 10.4
47 nonseminomatous germ cell tumor 10.4
48 testicular gonadoblastoma 10.4 KIT AFP
49 central nervous system immature teratoma 10.4 SOX2 NES
50 malignant gastric teratoma 10.4 KIT AFP

Graphical network of the top 20 diseases related to Embryonal Carcinoma:



Diseases related to Embryonal Carcinoma
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Symptoms & Phenotypes for Embryonal Carcinoma

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MGI Mouse Phenotypes related to Embryonal Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 10.16 BMP4 FGF4 GDF3 KIT PODXL POU5F1
2 endocrine/exocrine gland MP:0005379 10.07 AFP BMP4 KIT NR6A1 POU5F1 RARA
3 embryo MP:0005380 10.06 BMP4 FGF4 GDF3 KIT NES NR6A1
4 limbs/digits/tail MP:0005371 10.03 BMP4 CRABP2 FGF4 HOTAIR KIT NR6A1
5 cellular MP:0005384 10 BMP4 FGF4 GDF3 KIT NES PODXL
6 hearing/vestibular/ear MP:0005377 9.88 BMP4 CRABP2 KIT RARA RARB SOX2
7 respiratory system MP:0005388 9.7 BMP4 FGF4 KIT PODXL RARA RARB
8 reproductive system MP:0005389 9.65 AFP BMP4 FGF4 KIT NR6A1 POU5F1
9 mortality/aging MP:0010768 9.44 BMP4 CRABP2 FGF4 GDF3 KIT NES
Sources

Drugs & Therapeutics for Embryonal Carcinoma

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Drugs for Embryonal Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3 15663-27-1 2767 5702198 441203
2
Bleomycin Approved, Investigational Phase 3 9041-93-4, 11056-06-7 5360373
3
Etoposide Approved Phase 3 33419-42-0 36462
4
Picropodophyllin Approved, Investigational Phase 3 518-28-5, 477-47-4 10607 72435
5
Etoposide phosphate Phase 3 16760419
6 Antimitotic Agents Phase 3
7 Keratolytic Agents Phase 3
8 Tubulin Modulators Phase 3
9 Antibiotics, Antitubercular Phase 3
10 Dermatologic Agents Phase 3
11
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
12
Lenograstim Approved, Investigational Phase 2 135968-09-1
13
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
14
Ifosfamide Approved Phase 2 3778-73-2 3690
15
Levonorgestrel Approved, Investigational Phase 2 797-63-7 13109
16
Coenzyme M Approved, Investigational Phase 2 3375-50-6 598 23662354
17
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
18
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 38904
19
Mechlorethamine Approved, Investigational Phase 1, Phase 2 51-75-2 4033
20
Melphalan Approved Phase 1, Phase 2 148-82-3 4053 460612
21
Sorbitol Approved, Investigational Phase 1, Phase 2 69-65-8, 50-70-4 453 6251 5780
22
Irinotecan Approved, Investigational Phase 1, Phase 2 97682-44-5, 100286-90-6 60838
23
Brentuximab vedotin Approved, Investigational Phase 2 914088-09-8
24
D-Phenylalanine Approved, Experimental, Investigational, Nutraceutical Phase 1, Phase 2 63-91-2, 673-06-3 6140 71567
25
Palifosfamide Investigational Phase 2 31645-39-3 100427
26
MK-1775 Investigational Phase 1, Phase 2 955365-80-7 24856436
27
Camptothecin Experimental Phase 1, Phase 2 7689-03-4 24360
28 Albumin-Bound Paclitaxel Phase 2
29 Adjuvants, Immunologic Phase 2
30 Anti-Bacterial Agents Phase 1, Phase 2
31 Immunologic Factors Phase 1, Phase 2
32 Alkylating Agents Phase 1, Phase 2
33 Antineoplastic Agents, Alkylating Phase 1, Phase 2
34 Immunosuppressive Agents Phase 1, Phase 2
35 Protective Agents Phase 1, Phase 2
36 Anti-Infective Agents Phase 1, Phase 2
37 Nitrogen Mustard Compounds Phase 1, Phase 2
38 Antidotes Phase 1, Phase 2
39
Sodium thiosulfate Phase 1, Phase 2
40 Antitubercular Agents Phase 1, Phase 2
41 Antioxidants Phase 1, Phase 2
42 diuretics Phase 1, Phase 2
43 Chelating Agents Phase 1, Phase 2
44 topoisomerase I inhibitors Phase 1, Phase 2
45 Antineoplastic Agents, Immunological Phase 2
46
D-Alanine Experimental, Nutraceutical Phase 1, Phase 2 302-72-7, 338-69-2, 56-41-7 101757026 602 71080 5950
47
Ipilimumab Approved Phase 1 477202-00-9
48 Immunoglobulins, Intravenous Phase 1
49 Immunoglobulins Phase 1
50 Immune Checkpoint Inhibitors Phase 1

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 A Phase III Study Of Reduced Therapy In The Treatment Of Children With Low And Intermediate Risk Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
2 A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Carboplatin;Cisplatin;Etoposide
3 Treatment of Recurrent or Resistant Pediatric Malignant Germ Cell Tumors With Paclitaxel, Ifosfamide and Carboplatin Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
4 A Phase 2 Trial of Chemotherapy Followed by Response-Based Whole Ventricular &Amp; Spinal Canal Irradiation (WVSCI) for Patients With Localized Non-Germinomatous Central Nervous System Germ Cell Tumor Recruiting NCT04684368 Phase 2 Carboplatin;Etoposide;Ifosfamide;Mesna;Thiotepa
5 Phase I/II Study of Intra-Arterial Melphalan Given With Intra-Arterial Carboplatin, Osmotic Blood-Brain Barrier Disruption and Delayed Otoprotective Sodium Thiosulfate for Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Active, not recruiting NCT00983398 Phase 1, Phase 2 Carboplatin;Mannitol;Melphalan;Sodium Thiosulfate
6 A Phase 1/2 Study of AZD1775 (MK-1775) in Combination With Oral Irinotecan in Children, Adolescents, and Young Adults With Relapsed or Refractory Solid Tumors Active, not recruiting NCT02095132 Phase 1, Phase 2 Adavosertib;Irinotecan Hydrochloride
7 A Multicenter Phase II Study of Brentuximab Vedotin in Relapsed/Refractory Germ Cell Tumors Terminated NCT02689219 Phase 2 Brentuximab Vedotin
8 CTLA-4 Blockade With MDX-010 to Induce Graft-Versus-Malignancy Effects Following Allogeneic Hematopoietic Stem Cell Transplantation Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
9 Molecular Epidemiology of Pediatric Germ Cell Tumors Completed NCT01434355
10 A Prospective Study of Cognitive Function During Chemotherapy for Front-Line Treatment of Ovarian, Primary Peritoneal or Fallopian Tube Cancer Completed NCT01080521
11 Gene Expression Profiling of Infant Embryonal Central Nervous System Tumors by Microarray Gene Chip Analysis: Angiogenesis, Invasion and Metastasis Completed NCT00010114
12 Pediatric Germ Cell Tumors: Outcomes, Genomics and Epigenetics Recruiting NCT05564026

Search NIH Clinical Center for Embryonal Carcinoma

Cochrane evidence based reviews: carcinoma, embryonal

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Genetic Tests for Embryonal Carcinoma

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Anatomical Context for Embryonal Carcinoma

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Organs/tissues related to Embryonal Carcinoma:

FMA: Ovaries, Testes
MalaCards : Testes, Brain, Liver, Eye, Testis, Lymph Node, Pineal
Sources

Publications for Embryonal Carcinoma

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Articles related to Embryonal Carcinoma:

(show top 50) (show all 4382)
# Title Authors PMID Year
1
Alpha-fetoprotein-producing non-germ cell tumours of the female genital tract. 53 62
20185298 2010
2
Expression of embryonic stem cell markers in cultured JKT-1, a cell line derived from a human seminoma. 53 62
19226408 2010
3
Analysis of SOX2 expression in developing human testis and germ cell neoplasia. 53 62
19876845 2010
4
Reprogramming of Xist against the pluripotent state in fusion hybrids. 53 62
19843582 2009
5
Tumour microvessel endothelial cell KIT and stem cell factor expression in human solid tumours. 53 62
19912360 2009
6
Necdin: a multi functional protein with potential tumor suppressor role? 53 62
19626646 2009
7
The role of promoter CpG methylation in the epigenetic control of stem cell related genes during differentiation. 53 62
19221495 2009
8
Midkine translocated to nucleoli and involved in carcinogenesis. 53 62
19152444 2009
9
miR-302b maintains "stemness" of human embryonal carcinoma cells by post-transcriptional regulation of Cyclin D2 expression. 53 62
18930031 2008
10
Expression of RALDHs (ALDH1As) and CYP26s in human tissues and during the neural differentiation of P19 embryonal carcinoma stem cell. 53 62
18502188 2008
11
Regulation of human Cripto-1 gene expression by TGF-beta1 and BMP-4 in embryonal and colon cancer cells. 53 62
17941089 2008
12
Nestin expression in central nervous system germ cell tumors. 53 62
18092184 2008
13
Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. 53 62
18045648 2008
14
Testicular maturation arrest to testis cancer: spectrum of expression of the vitamin D receptor and vitamin D treatment in vitro. 53 62
17644135 2007
15
Selective repression of retinoic acid target genes by RIP140 during induced tumor cell differentiation of pluripotent human embryonal carcinoma cells. 53 62
17880687 2007
16
Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells. 53 62
17663992 2007
17
Dynamic and selective interactions of the transcriptional corepressor TIF1 beta with the heterochromatin protein HP1 isotypes during cell differentiation. 53 62
17381543 2007
18
Transcriptional regulation of human Oct4 by steroidogenic factor-1. 53 62
17226773 2007
19
[Malignant ovarian germ cell tumours: a trial of 36 cases]. 53 62
17350873 2007
20
Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract. 53 62
17314394 2007
21
Utility of ALK-1 protein expression and ALK rearrangements in distinguishing inflammatory myofibroblastic tumor from malignant spindle cell lesions of the urinary bladder. 53 62
17396140 2007
22
Q2ChIP, a quick and quantitative chromatin immunoprecipitation assay, unravels epigenetic dynamics of developmentally regulated genes in human carcinoma cells. 53 62
17272500 2007
23
Nestin is expressed in the basal/myoepithelial layer of the mammary gland and is a selective marker of basal epithelial breast tumors. 53 62
17234757 2007
24
OCT4: biological functions and clinical applications as a marker of germ cell neoplasia. 53 62
17117392 2007
25
Elevating the levels of Sox2 in embryonal carcinoma cells and embryonic stem cells inhibits the expression of Sox2:Oct-3/4 target genes. 53 62
17324942 2007
26
Oncofetal protein glypican-3 in testicular germ-cell tumor. 53 62
16896894 2006
27
Differential activity of the FGF-4 enhancer in F9 and P19 embryonal carcinoma cells. 53 62
16523502 2006
28
Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. 53 62
16793513 2006
29
OAZ regulates bone morphogenetic protein signaling through Smad6 activation. 53 62
16373339 2006
30
Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors. 53 62
16424014 2006
31
The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation. 53 62
16344469 2005
32
CD30 (Ki-1) molecule expression in human embryonal epithelial cells of the basal layer of the developing epidermis and epidermal buds and its potential significance for embryogenesis. 53 62
16200333 2005
33
Differentiation of human embryonal carcinomas in vitro and in vivo reveals expression profiles relevant to normal development. 53 62
15994931 2005
34
Distal enhancer of the mouse FGF-4 gene and its human counterpart exhibit differential activity: critical role of a GT box. 53 62
15803454 2005
35
Targeted inhibition of the transcription factor YY1 in an embryonal carcinoma cell line results in retarded cell growth, elevated levels of p53 but no increase in apoptotic cell death. 53 62
16003908 2005
36
Overexpression of anti-apoptotic Mcl-1 in testicular germ cell tumours. 53 62
15842635 2005
37
OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma. 53 62
15725806 2005
38
Human embryonal epithelial cells of the developing small intestinal crypts can express the Hodgkin-cell associated antigen Ki-1 (CD30) in spontaneous abortions during the first trimester of gestation. 53 62
15644135 2005
39
NF-Y behaves as a bifunctional transcription factor that can stimulate or repress the FGF-4 promoter in an enhancer-dependent manner. 53 62
16128003 2005
40
Retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells is potentiated by leukemia inhibitory factor. 53 62
15641927 2005
41
Sox7 plays crucial roles in parietal endoderm differentiation in F9 embryonal carcinoma cells through regulating Gata-4 and Gata-6 expression. 53 62
15542856 2004
42
Oncogenic role of NALP7 in testicular seminomas. 53 62
15596043 2004
43
Transcription factor Sox-2 inhibits co-activator stimulated transcription. 53 62
15349837 2004
44
Association of the transcriptional corepressor TIF1beta with heterochromatin protein 1 (HP1): an essential role for progression through differentiation. 53 62
15342492 2004
45
Necdin interacts with the Msx2 homeodomain protein via MAGE-D1 to promote myogenic differentiation of C2C12 cells. 53 62
15272023 2004
46
Receptor interacting protein 140 as a thyroid hormone-dependent, negative co-regulator for the induction of cellular retinoic acid binding protein I gene. 53 62
15130509 2004
47
Specific knockdown of Oct4 and beta2-microglobulin expression by RNA interference in human embryonic stem cells and embryonic carcinoma cells. 53 62
15342930 2004
48
Negative feedback at the level of nuclear receptor coregulation. Self-limitation of retinoid signaling by RIP140. 53 62
14506269 2003
49
Oct-4-expressing cells in human amniotic fluid: a new source for stem cell research? 53 62
12832377 2003
50
p27 and cyclin E/D2 associations in testicular germ cell tumors: implications for tumorigenesis. 53 62
12777997 2003
Sources

Variations for Embryonal Carcinoma

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Cosmic variations for Embryonal Carcinoma:

8
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM88315457 KIT ovary,NS,germ cell tumour,embryonal carcinoma c.1965T>A p.N655K 4:54728096-54728096 7
2 COSM133536937 AKT1 ovary,NS,germ cell tumour,embryonal carcinoma c.967G>A p.D323N 14:104773083-104773083 7
3 COSM105585949 AKT1 ovary,NS,germ cell tumour,embryonal carcinoma c.967G>A p.D323N 14:104773083-104773083 7
4 COSM134536549 AKT1 ovary,NS,germ cell tumour,embryonal carcinoma c.967G>A p.D323N 14:104773083-104773083 7
5 COSM103843275 AKT1 ovary,NS,germ cell tumour,embryonal carcinoma c.967G>A p.D323N 14:104773083-104773083 7
6 COSM89234463 AKT1 ovary,NS,germ cell tumour,embryonal carcinoma c.967G>A p.D323N 14:104773083-104773083 7
7 COSM136350617 AKT1 ovary,NS,germ cell tumour,embryonal carcinoma c.967G>A p.D323N 14:104773083-104773083 7
Sources

Expression for Embryonal Carcinoma

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Search GEO for disease gene expression data for Embryonal Carcinoma.
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Pathways for Embryonal Carcinoma

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Pathways related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 64
Show member pathways
 13.66 TNFRSF8 TDGF1 SOX2 RARB RARA KIT
2
Nanog in Mammalian ESC Pluripotency 64
Show member pathways
 13.11 TDGF1 SOX2 POU5F1 KIT FGF4 BMP4
3
Overview of interferons-mediated signaling pathway 74
Show member pathways
 12.48 TDGF1 RARB RARA KIT FGF4 CRABP2
4
Human Embryonic Stem Cell Pluripotency 64
Show member pathways
 12.34 TDGF1 SOX2 POU5F1 FGF4 BMP4
5
Mesodermal commitment pathway 74
11.93 SOX2 RARB POU5F1 GDF3 BMP4
6
Wnt / Hedgehog / Notch 3
11.89 TDGF1 SOX2 POU5F1 NR6A1 BMP4 AFP
7
Nuclear receptors 74
Show member pathways
 11.83 RARB RARA NR6A1
8
Gastrulation 66
Show member pathways
 11.78 SOX2 POU5F1 BMP4
9
Mesenchymal Stem Cells and Lineage-specific Markers 65
11.76 TDGF1 KIT FGF4 BMP4
10
Neural Stem Cells and Lineage-specific Markers 65
11.66 BMP4 FGF4 NES SOX2
11
Endoderm differentiation 74
11.59 SOX2 POU5F1 GDF3
12
Signaling by Retinoic Acid 66
Show member pathways
 11.54 CRABP2 RARA RARB
13
Cardiac progenitor differentiation 74
11.43 SOX2 POU5F1 KIT BMP4
14
Pluripotent stem cell differentiation pathway 74
11.39 KIT FGF4 BMP4
15
Development of ureteric collection system 74
11.35 RARB RARA BMP4
16
Vitamin A and carotenoid metabolism 74
11.31 RARB RARA CRABP2
17
Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers 65
11.29 SOX2 POU5F1 PODXL NES FGF4 BMP4
18
Transcriptional regulation of pluripotent stem cells 66
Show member pathways
 11.13 NR6A1 POU5F1 SOX2 TDGF1
19
Human Early Embryo Development 64
Show member pathways
 10.5 SOX2 POU5F1 BMP4
20
Oct4 in Mammalian ESC Pluripotency 64
10.49 SOX2 POU5F1 NR6A1 FGF4
Sources

GO Terms for Embryonal Carcinoma

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Biological processes related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAPK cascade GO:0043410 10.15 TDGF1 SOX2 KIT BMP4
2 SMAD protein signal transduction GO:0060395 10.04 GDF3 BMP4 AFP
3 stem cell proliferation GO:0072089 9.99 RARB NES FGF4
4 podocyte development GO:0072015 9.86 PODXL BMP4
5 ureteric bud development GO:0001657 9.85 RARB RARA BMP4
6 growth plate cartilage development GO:0003417 9.84 RARA RARB
7 lymphoid progenitor cell differentiation GO:0002320 9.8 KIT BMP4
8 endodermal cell fate specification GO:0001714 9.78 POU5F1 SOX2
9 glandular epithelial cell development GO:0002068 9.76 RARA RARB
10 bone development GO:0060348 9.75 RARB RARA BMP4
11 cranial suture morphogenesis GO:0060363 9.73 BMP4 FGF4
12 embryonic hindlimb morphogenesis GO:0035116 9.73 BMP4 FGF4 RARB
13 chondroblast differentiation GO:0060591 9.71 RARA FGF4
14 negative regulation of cartilage development GO:0061037 9.7 RARA RARB
15 ventricular cardiac muscle cell differentiation GO:0055012 9.62 RARB RARA
16 regulation of cell fate commitment GO:0010453 9.46 GDF3 BMP4
17 negative regulation of miRNA transcription GO:1902894 9.43 RARA POU5F1 BMP4
18 somatic stem cell population maintenance GO:0035019 9.23 SOX2 POU5F1 KIT FGF4

Molecular functions related to Embryonal Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.76 SOX2 RARB RARA POU5F1 NR6A1
2 growth factor activity GO:0008083 9.56 TDGF1 GDF3 FGF4 BMP4
3 nuclear receptor activity GO:0004879 9.1 RARB RARA NR6A1
Sources

Sources for Embryonal Carcinoma

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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