MCID: EMB007
MIFTS: 46

Embryonal Sarcoma

Categories: Rare diseases, Fetal diseases, Cancer diseases

Aliases & Classifications for Embryonal Sarcoma

MalaCards integrated aliases for Embryonal Sarcoma:

Name: Embryonal Sarcoma 53
Undifferentiated Sarcoma 73

Classifications:



External Ids:

UMLS 73 C0855073

Summaries for Embryonal Sarcoma

MalaCards based summary : Embryonal Sarcoma, also known as undifferentiated sarcoma, is related to undifferentiated embryonal sarcoma of the liver and fibrous histiocytoma, and has symptoms including fever An important gene associated with Embryonal Sarcoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Gastric cancer. The drugs Lenograstim and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and lung, and related phenotypes are Decreased influenza A/WSN/33 replication and behavior/neurological

Related Diseases for Embryonal Sarcoma

Diseases related to Embryonal Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 199)
# Related Disease Score Top Affiliating Genes
1 undifferentiated embryonal sarcoma of the liver 31.2 CDK4 MALAT1 MDM2 MYOD1 MYOG PEG3
2 fibrous histiocytoma 29.7 DES S100B SERPINA3 VIM
3 hepatoblastoma 29.7 CTNNB1 GPC3 TP53
4 embryonal rhabdomyosarcoma 28.9 CDK4 DES MYOD1 MYOG
5 histiocytoma 28.2 CDK4 KIT MDM2 MYOD1 SERPINA3 TP53
6 rhabdomyosarcoma 28.0 CDK4 DES MDM2 MYOD1 MYOG TP53
7 malignant fibroxanthoma 27.0 CDK4 DES MDM2 MKI67 MYOD1 S100B
8 intravascular papillary endothelial hyperplasia 11.0 SERPINA3 VIM
9 hydromyelia 11.0 S100B VIM
10 bednar tumor 10.9 S100B VIM
11 primary hepatic neuroendocrine carcinoma 10.9 S100B VIM
12 zika virus infection 10.9 MDM2 TP53
13 fibrous meningioma 10.8 S100B VIM
14 malignant giant cell tumor 10.8 S100B TP53
15 chordoid meningioma 10.8 S100B VIM
16 acinar cell cystadenocarcinoma 10.8 MKI67 SERPINA3
17 brain ependymoma 10.8 MKI67 TP53
18 retroperitoneal fibrosis 10.8 MDM2 VIM
19 actinic cheilitis 10.8 MDM2 TP53
20 eccrine porocarcinoma 10.8 S100B VIM
21 reticular perineurioma 10.8 KIT S100B
22 prostate embryonal rhabdomyosarcoma 10.8 KIT MYOD1
23 mast-cell sarcoma 10.8 KIT VIM
24 sarcoma 10.7
25 odontogenic myxoma 10.7 S100B SERPINA3 VIM
26 spitz nevus 10.7 MKI67 TP53
27 sclerosing liposarcoma 10.7 MDM2 TP53
28 spiradenoma 10.7 S100B TP53 VIM
29 ameloblastic carcinoma 10.7 MKI67 VIM
30 malignant mixed mullerian tumor 10.7 KIT VIM
31 mixed type thymoma 10.7 KIT S100B
32 lip cancer 10.7 MDM2 TP53
33 endometrial mucinous adenocarcinoma 10.7 MKI67 VIM
34 cerebral primitive neuroectodermal tumor 10.7 S100B TP53 VIM
35 optic nerve glioma 10.7 S100B TP53 VIM
36 sarcomatoid squamous cell skin carcinoma 10.7 KIT TP53
37 infantile digital fibromatosis 10.7 DES VIM
38 ependymoblastoma 10.7 TP53 VIM
39 prostate rhabdomyosarcoma 10.7 KIT MYOD1
40 myxopapillary ependymoma 10.6 S100B VIM
41 anaplastic ependymoma 10.6 MDM2 S100B VIM
42 extraosseous ewing's sarcoma 10.6 MYOD1 MYOG S100B
43 lymphangiomatosis 10.6 DES VIM
44 angiolipoma 10.6 DES VIM
45 primitive neuroectodermal tumor of the cervix uteri 10.6 DES VIM
46 ependymoma 10.6 MKI67 S100B VIM
47 conventional leiomyosarcoma 10.6 MYOD1 MYOG
48 female reproductive endometrioid cancer 10.6 CTNNB1 TP53
49 cellular schwannoma 10.6 MDM2 S100B TP53
50 monophasic synovial sarcoma 10.6 S100B VIM

Graphical network of the top 20 diseases related to Embryonal Sarcoma:



Diseases related to Embryonal Sarcoma

Symptoms & Phenotypes for Embryonal Sarcoma

UMLS symptoms related to Embryonal Sarcoma:


fever

GenomeRNAi Phenotypes related to Embryonal Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased influenza A/WSN/33 replication GR00195-A-1 8.92 AXIN1 CTNNB1 MDM2 MYOD1

MGI Mouse Phenotypes related to Embryonal Sarcoma:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.33 TP53 MYOG PEG3 VIM S100B AXIN1
2 cardiovascular system MP:0005385 10.28 TP53 VIM MYOD1 AXIN1 CTNNB1 CDK4
3 cellular MP:0005384 10.27 TP53 PEG3 VIM AXIN1 CTNNB1 DES
4 homeostasis/metabolism MP:0005376 10.26 MYOD1 TP53 MYOG S100B VIM CTNNB1
5 mortality/aging MP:0010768 10.26 TP53 MYOG PEG3 MYOD1 VIM AXIN1
6 growth/size/body region MP:0005378 10.24 MYOD1 TP53 MYOG PEG3 CDK4 AXIN1
7 embryo MP:0005380 10.2 TP53 MYOG VIM AXIN1 CTNNB1 CDK4
8 integument MP:0010771 10.11 TP53 MYOG S100B CTNNB1 CDK4 GPC3
9 muscle MP:0005369 10.11 MYOG VIM MYOD1 TP53 CTNNB1 CDK4
10 digestive/alimentary MP:0005381 10.1 TP53 AXIN1 CTNNB1 CDK4 GPC3 MDM2
11 normal MP:0002873 10.07 MYOG S100B TP53 AXIN1 CTNNB1 CDK4
12 craniofacial MP:0005382 10.04 TP53 AXIN1 CTNNB1 KIT GPC3 MDM2
13 limbs/digits/tail MP:0005371 9.97 TP53 AXIN1 CTNNB1 GPC3 MDM2 KIT
14 no phenotypic analysis MP:0003012 9.95 MYOD1 TP53 MYOG CTNNB1 MDM2 KIT
15 neoplasm MP:0002006 9.91 MYOD1 TP53 CDK4 CTNNB1 MDM2 KIT
16 reproductive system MP:0005389 9.85 PEG3 VIM MYOD1 TP53 AXIN1 CTNNB1
17 pigmentation MP:0001186 9.8 TP53 CTNNB1 CDK4 MDM2 KIT GPC3
18 renal/urinary system MP:0005367 9.8 TP53 AXIN1 CTNNB1 CDK4 GPC3 MDM2
19 respiratory system MP:0005388 9.56 TP53 MYOG VIM MYOD1 AXIN1 CTNNB1
20 skeleton MP:0005390 9.23 MYOD1 TP53 MYOG AXIN1 CTNNB1 GPC3

Drugs & Therapeutics for Embryonal Sarcoma

Drugs for Embryonal Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved, Investigational Phase 3 135968-09-1
2
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
3
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
4
Dactinomycin Approved, Investigational Phase 3 50-76-0 2019 457193
5
Etoposide Approved Phase 3 33419-42-0 36462
6
Idarubicin Approved Phase 3 58957-92-9 42890
7 Trofosfamide Investigational Phase 3 22089-22-1
8 Alkylating Agents Phase 3,Phase 2
9 Nucleic Acid Synthesis Inhibitors Phase 3
10 Anti-Bacterial Agents Phase 3,Phase 1
11 Antibiotics, Antitubercular Phase 3,Phase 1
12 Immunosuppressive Agents Phase 3,Phase 2
13 Anti-Infective Agents Phase 3
14 Antirheumatic Agents Phase 3,Phase 2
15 Antimitotic Agents Phase 3
16 Antineoplastic Agents, Alkylating Phase 3,Phase 2
17 Antineoplastic Agents, Phytogenic Phase 3
18 Topoisomerase Inhibitors Phase 3,Phase 1
19 Etoposide phosphate Phase 3
20
Pembrolizumab Approved Phase 2 1374853-91-4
21
nivolumab Approved Phase 2 946414-94-4
22 Antibodies Phase 2
23 Immunoglobulins Phase 2
24 Antibodies, Monoclonal Phase 2
25
Doxorubicin Approved, Investigational Phase 1 23214-92-8 31703
26
Doxil Approved June 1999 Phase 1 31703

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma Completed NCT00002995 Phase 3 cyclophosphamide;vincristine sulfate
2 Trial for Localised High-risk Rhabdomyosarcoma and Rhabdomyosarcoma-like Soft Tissue Sarcoma Recruiting NCT00876031 Phase 3 trofosfamide, idarubicin, etoposide
3 Combination of MK3475 and Metronomic Cyclophosphamide in Patients With Advanced Sarcomas : Multicentre Phase II Trial Recruiting NCT02406781 Phase 2 Combination of MK3475 with Metronomic CP
4 SARC028: A Phase II Study of the Anti-PD1 Antibody Pembrolizumab (MK-3475) in Patients With Advanced Sarcomas Recruiting NCT02301039 Phase 2 Pembrolizumab
5 A Study of Nivolumab in Selected Uterine Cancer Patients Recruiting NCT03241745 Phase 2 Nivolumab
6 Study of Doxorubicin and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and Intraoperative Brachytherapy for Unresectable or Refractory Pelvic and Abdominal Rhabdomyosarcoma and Undifferentiated Sarcomas in Children Not yet recruiting NCT03111069 Phase 1 Doxorubicin
7 Biomarker Differences in Samples From Patients With Undifferentiated Sarcomas Completed NCT01802125

Search NIH Clinical Center for Embryonal Sarcoma

Genetic Tests for Embryonal Sarcoma

Anatomical Context for Embryonal Sarcoma

MalaCards organs/tissues related to Embryonal Sarcoma:

41
Liver, Kidney, Lung, Brain, Prostate, T Cells, Pituitary

Publications for Embryonal Sarcoma

Articles related to Embryonal Sarcoma:

(show top 50) (show all 184)
# Title Authors Year
1
Hanging Undifferentiated Embryonal Sarcoma of the Liver in Adult: an Unusual Presentation of an Aggressive Tumor. ( 29779073 )
2018
2
Undifferentiated embryonal sarcoma of liver in an adult with spontaneous rupture and tumour thrombus in the right atrium. ( 29785758 )
2018
3
Unexpected Liver Embryonal Sarcoma in the Adult: Diagnosis and Treatment. ( 29971180 )
2018
4
Undifferentiated Embryonal Sarcoma of the Liver (UESL) in Adolescents: An Unexpected Diagnosis. ( 29702542 )
2018
5
Positive correlation between the density of macrophages and T-cells in undifferentiated sarcoma. ( 29980952 )
2018
6
Clinicopathologic Diversity of Undifferentiated Sarcoma With BCOR-CCNB3 Fusion: Analysis of 11 Cases With a Reappraisal of the Utility of Immunohistochemistry for BCOR and CCNB3. ( 28877060 )
2017
7
Undifferentiated embryonal sarcoma of the liver in a child: A whole exome sequencing analysis. ( 28539230 )
2017
8
Unresectable Undifferentiated Embryonal Sarcoma of the Liver in an Adult Male Treated with Chemotherapy and Orthotopic Liver Transplantation. ( 29226049 )
2017
9
A case of adult undifferentiated embryonal sarcoma of the liver successfully treated with right trisectionectomy: a case report. ( 28144858 )
2017
10
Undifferentiated embryonal sarcoma of the liver in a young female: treatment with portal vein embolization and liver trisectonectomy. ( 27621753 )
2016
11
A single-center experience with undifferentiated embryonal sarcoma of the liver. ( 27427850 )
2016
12
Undifferentiated Embryonal Sarcoma of the Liver (UESL): A Single-Center Experience and Review of the Literature. ( 26925712 )
2016
13
The Role of Liver Transplantation in Undifferentiated Embryonal Sarcoma of the Liver in Children. ( 27438021 )
2016
14
Characteristics and outcomes in children with undifferentiated embryonal sarcoma of the liver: A report from the National Cancer Database. ( 27781381 )
2016
15
Adult Embryonal Sarcoma of the Liver: Management of a Massive Liver Tumor. ( 27895954 )
2016
16
Undifferentiated embryonal sarcoma of the liver in an adult patient. ( 27377912 )
2016
17
A Case of Ruptured Adult Embryonal Sarcoma of the Liver with Excellent Outcome After Neoadjuvant Chemotherapy. ( 27714652 )
2016
18
Imaging features of undifferentiated embryonal sarcoma of the liver: a series of 15 children. ( 27562247 )
2016
19
Undifferentiated embryonal sarcoma of the liver with an unusual presentation: case report and review of the literature. ( 27034807 )
2016
20
Expression of PSMA in tumor neovasculature of high grade sarcomas including synovial sarcoma, rhabdomyosarcoma, undifferentiated sarcoma and MPNST. ( 28002805 )
2016
21
A rare case of malignant fibrous histiocytoma/ pleomorphic undifferentiated sarcoma of the kidney. ( 25738036 )
2015
22
Repeated hepatic resections and radio-frequency ablations may improve the survival of adult undifferentiated embryonal sarcoma of the liver: report of two cases. ( 26366352 )
2015
23
Undifferentiated (embryonal) sarcoma of liver. ( 26312248 )
2015
24
Undifferentiated Embryonal Sarcoma of Liver. ( 26788276 )
2015
25
BCOR-CCNB3 fusions are frequent in undifferentiated sarcomas of male children. ( 25360585 )
2015
26
A rare case of malignant fibrous histiocytoma (pleomorphic undifferentiated sarcoma NOS) of the vocal fold. ( 26214667 )
2015
27
Undifferentiated embryonal sarcoma of the liver: a concise review. ( 25611111 )
2015
28
Pre-operatively misdiagnosed undifferentiated embryonal sarcoma of the liver: analysis of 16 cases. ( 26807408 )
2015
29
Multimodal therapy including liver transplantation for hepatic undifferentiated embryonal sarcoma. ( 24142883 )
2014
30
Undifferentiated embryonal sarcoma of liver: a multi-institutional experience with 9 cases. ( 25674229 )
2014
31
A case of an undifferentiated embryonal sarcoma of the liver mimicking a liver abscess. ( 25364566 )
2014
32
Mesenchymal hamartoma or embryonal sarcoma of the liver in childhood: a difficult diagnosis before complete surgical excision. ( 25148740 )
2014
33
Undifferentiated embryonal sarcoma in adult liver. ( 25214865 )
2014
34
Primary undifferentiated embryonal sarcoma of the liver misdiagnosed as hydatid cyst in a child: a case report and review of the literature. ( 25603636 )
2014
35
Diagnosis and therapy of primary undifferentiated embryonal sarcoma of the liver. ( 24762610 )
2014
36
Transformation of a Primitive Myxoid Mesenchymal Tumor of Infancy to an Undifferentiated Sarcoma: A First Reported Case. ( 24390443 )
2014
37
A Rare Case of Childhood Undifferentiated Embryonal Sarcoma of the Liver Managed Successfully. ( 26157829 )
2014
38
Undifferentiated embryonal sarcoma of the liver mistaken for hepatic abscess in an adult. ( 25120683 )
2014
39
MR imaging of myxofibrosarcoma and undifferentiated sarcoma with emphasis on tail sign; diagnostic and prognostic value. ( 24889995 )
2014
40
Remarkable regression of a lung recurrence from an undifferentiated embryonal sarcoma of the liver treated with a DC vaccine combined with immune cells: a case report. ( 25038546 )
2014
41
Undifferentiated embryonal sarcoma of the liver in a child: A case report and review of the literature. ( 23426588 )
2013
42
Undifferentiated sarcoma of the cavernous sinus after gamma knife radiosurgery for pituitary adenoma. ( 23587603 )
2013
43
Undifferentiated Sarcoma of the Liver: A Case Study of an Erythropoietin-Secreting Tumor. ( 24038117 )
2013
44
Undifferentiated embryonal sarcoma of the liver in a middle-aged adult with systemic lupus erythematosus. ( 24073982 )
2013
45
Pleomorphic undifferentiated sarcoma of urinary bladder with calcified pulmonary metastasis: A rare entity. ( 24082450 )
2013
46
Undifferentiated embryonal sarcoma of the liver with focal osteoid picture-a case report. ( 24054758 )
2013
47
Characterization of translocations in mesenchymal hamartoma and undifferentiated embryonal sarcoma of the liver. ( 24120702 )
2013
48
Undifferentiated sarcoma arising at lower thoracic spine with neuroblastoma-like dumbbell-shaped radiographic appearance in a 1-year-old girl. ( 24291700 )
2013
49
Management of undifferentiated embryonal sarcoma of the liver in children: a case series and management review. ( 24079623 )
2013
50
Treatment of undifferentiated embryonal sarcoma of the liver in children--single center experience. ( 24210186 )
2013

Variations for Embryonal Sarcoma

Expression for Embryonal Sarcoma

Search GEO for disease gene expression data for Embryonal Sarcoma.

Pathways for Embryonal Sarcoma

Pathways related to Embryonal Sarcoma according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.76 AXIN1 CDK4 CTNNB1 KIT MDM2 TP53
2
Show member pathways
12.62 AXIN1 CDK4 CTNNB1 KIT TP53
3
Show member pathways
12.48 AXIN1 CDK4 CTNNB1 KIT MDM2 TP53
4 12.19 CDK4 MDM2 MKI67 TP53 VIM
5 12.15 CTNNB1 GPC3 MDM2 TP53
6 12.15 AXIN1 CDK4 CTNNB1 KIT MDM2 TP53
7 11.97 CDK4 CTNNB1 MDM2 TP53
8 11.91 AXIN1 CTNNB1 MDM2 TP53
9
Show member pathways
11.91 AXIN1 CTNNB1 GPC3 TP53
10 11.85 CDK4 TP53 VIM
11 11.83 CTNNB1 MDM2 TP53
12
Show member pathways
11.73 AXIN1 CDK4 CTNNB1 TP53 VIM
13 11.7 CDK4 MDM2 TP53
14 11.62 CTNNB1 MKI67 VIM
15 11.61 CDK4 MDM2 TP53
16 11.52 AXIN1 CTNNB1 MDM2 TP53
17
Show member pathways
11.48 CTNNB1 MYOD1 MYOG
18 11.35 CDK4 MDM2 TP53
19 11.31 CDK4 MDM2 TP53
20 11.07 AXIN1 CDK4 CTNNB1 MDM2 TP53
21 11.05 CDK4 MDM2 TP53
22 10.86 AXIN1 CTNNB1

GO Terms for Embryonal Sarcoma

Cellular components related to Embryonal Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear body GO:0016604 9.56 MDM2 MKI67 MYOD1 TP53
2 beta-catenin destruction complex GO:0030877 9.16 AXIN1 CTNNB1
3 fascia adherens GO:0005916 8.96 CTNNB1 DES
4 transcription factor complex GO:0005667 8.92 CDK4 CTNNB1 MYOD1 MYOG
5 nucleus GO:0005634 10.1 AXIN1 CDK4 CTNNB1 DES MDM2 MKI67

Biological processes related to Embryonal Sarcoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.88 AXIN1 CTNNB1 MYOD1 MYOG TP53
2 positive regulation of apoptotic process GO:0043065 9.85 CDK4 CTNNB1 S100B TP53
3 positive regulation of cell proliferation GO:0008284 9.83 CDK4 CTNNB1 KIT MDM2 S100B
4 cellular response to hypoxia GO:0071456 9.67 MDM2 S100B TP53
5 positive regulation of gene expression GO:0010628 9.65 CTNNB1 KIT MDM2 TP53 VIM
6 anterior/posterior axis specification GO:0009948 9.54 CTNNB1 GPC3
7 positive regulation of myoblast fusion GO:1901741 9.52 MYOD1 MYOG
8 intermediate filament organization GO:0045109 9.51 DES VIM
9 cellular response to growth factor stimulus GO:0071363 9.5 CTNNB1 MDM2 MYOG
10 myotube differentiation GO:0014902 9.46 MYOD1 MYOG
11 positive regulation of skeletal muscle fiber development GO:0048743 9.4 MYOD1 MYOG
12 muscle cell fate commitment GO:0042693 9.37 MYOD1 MYOG
13 cellular response to actinomycin D GO:0072717 9.16 MDM2 TP53
14 positive regulation of muscle cell differentiation GO:0051149 9.13 CTNNB1 MYOD1 MYOG
15 regulation of gene expression GO:0010468 9.02 CDK4 CTNNB1 MDM2 MYOD1 PEG3

Molecular functions related to Embryonal Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.73 AXIN1 DES MDM2 S100B TP53 VIM
2 ubiquitin protein ligase binding GO:0031625 9.62 AXIN1 MDM2 MYOD1 TP53
3 enzyme binding GO:0019899 9.35 AXIN1 CTNNB1 MDM2 MYOD1 TP53
4 I-SMAD binding GO:0070411 9.16 AXIN1 CTNNB1
5 disordered domain specific binding GO:0097718 8.8 CTNNB1 MDM2 TP53

Sources for Embryonal Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....