MCID: EMB007
MIFTS: 40

Embryonal Sarcoma

Categories: Cancer diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Embryonal Sarcoma

MalaCards integrated aliases for Embryonal Sarcoma:

Name: Embryonal Sarcoma 20
Undifferentiated Sarcoma 70

Classifications:



External Ids:

UMLS 70 C0855073

Summaries for Embryonal Sarcoma

MalaCards based summary : Embryonal Sarcoma, also known as undifferentiated sarcoma, is related to rare tumor and spindle cell sarcoma, and has symptoms including fever An important gene associated with Embryonal Sarcoma is MYOG (Myogenin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Endometrial cancer. The drugs Sargramostim and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and prostate, and related phenotypes are Decreased influenza A/WSN/33 replication and behavior/neurological

Related Diseases for Embryonal Sarcoma

Diseases related to Embryonal Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 349)
# Related Disease Score Top Affiliating Genes
1 rare tumor 31.0 KIT DES
2 spindle cell sarcoma 30.5 VIM SERPINA3 S100B MYOG MDM2 KIT
3 undifferentiated embryonal sarcoma of the liver 30.5 TP53 SERPINA3 PEG3 MYOG MYOD1 MDM2
4 cystadenocarcinoma 30.4 VIM TP53 SERPINA3
5 sarcoma 30.3 VIM TP53 S100B MYOG MDM2 KIT
6 soft tissue sarcoma 30.2 TP53 MKI67 MDM2
7 hepatoblastoma 30.1 TP53 SERPINA3 MDM2 GPC3 CTNNB1
8 prostate rhabdomyosarcoma 30.0 MYOG MYOD1
9 malignant mesenchymoma 29.9 SERPINA3 MYOG MYOD1 MDM2 DES
10 mesenchymal cell neoplasm 29.9 TP53 SERPINA3 MYOG KIT
11 fibrous histiocytoma 29.9 VIM SERPINA3 S100B KIT DES
12 botryoid rhabdomyosarcoma 29.9 MYOG MYOD1 DES
13 liver cirrhosis 29.7 TP53 SERPINA3 MALAT1 GPC3 CTNNB1
14 li-fraumeni syndrome 29.7 TP53 MDM2 CTNNB1 CDK4
15 embryonal rhabdomyosarcoma 29.4 TP53 MYOG MYOD1 MDM2 DES CDK4
16 chondrosarcoma 29.4 VIM SERPINA3 S100B MDM2 CDK4
17 pilocytic astrocytoma 29.4 TP53 S100B CDK4
18 malignant astrocytoma 29.0 VIM TP53 SERPINA3 S100B MDM2 CTNNB1
19 ovarian cancer 28.4 VIM TP53 MDM2 MALAT1 KIT GPC3
20 rhabdomyosarcoma 28.3 VIM TP53 S100B MYOG MYOD1 MDM2
21 malignant fibrous histiocytoma 28.2 VIM TP53 SERPINA3 S100B MYOG MYOD1
22 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.5
23 liver sarcoma 10.5
24 intravascular papillary endothelial hyperplasia 10.4 VIM SERPINA3
25 heart lymphoma 10.4 VIM MYOG
26 scrotum neoplasm 10.4 SERPINA3 MYOG
27 vulvar intraepithelial neoplasia 10.4 TP53 CTNNB1
28 multicentric reticulohistiocytosis 10.4 VIM SERPINA3
29 infantile digital fibromatosis 10.4 VIM DES
30 adult malignant schwannoma 10.3 TP53 MYOG
31 primitive neuroectodermal tumor of the cervix uteri 10.3 VIM DES
32 ovarian mucinous cystadenocarcinoma 10.3 VIM SERPINA3
33 xanthogranulomatous cholecystitis 10.3 TP53 SERPINA3
34 lymphangiomatosis 10.3 VIM DES
35 liver angiosarcoma 10.3 VIM TP53
36 breast sarcoma 10.3 TP53 MYOG
37 chondroid chordoma 10.3 VIM SERPINA3
38 cervical polyp 10.3 MYOG DES
39 benign metastasizing leiomyoma 10.3 VIM DES
40 medullomyoblastoma 10.3 MYOG DES
41 cutaneous solitary mastocytoma 10.3 SERPINA3 KIT
42 testicular malignant germ cell cancer 10.3 SERPINA3 GPC3
43 ectomesenchymoma 10.3 MYOG DES
44 type c thymoma 10.3 SERPINA3 KIT
45 liver fibroma 10.3 VIM KIT
46 intratubular embryonal carcinoma 10.3 TP53 KIT
47 parachordoma 10.3 VIM DES
48 senile angioma 10.3 VIM KIT
49 mammary analogue secretory carcinoma 10.3 TP53 CTNNB1
50 esophageal adenoid cystic carcinoma 10.3 VIM KIT

Graphical network of the top 20 diseases related to Embryonal Sarcoma:



Diseases related to Embryonal Sarcoma

Symptoms & Phenotypes for Embryonal Sarcoma

UMLS symptoms related to Embryonal Sarcoma:


fever

GenomeRNAi Phenotypes related to Embryonal Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased influenza A/WSN/33 replication GR00195-A-1 8.92 AXIN1 CTNNB1 MDM2 MYOD1

MGI Mouse Phenotypes related to Embryonal Sarcoma:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.35 AXIN1 CDK4 CTNNB1 DES KIT MDM2
2 cellular MP:0005384 10.3 AXIN1 CDK4 CTNNB1 DES GPC3 KIT
3 homeostasis/metabolism MP:0005376 10.29 CDK4 CTNNB1 DES GPC3 KIT MDM2
4 cardiovascular system MP:0005385 10.27 AXIN1 CDK4 CTNNB1 DES GPC3 KIT
5 mortality/aging MP:0010768 10.26 AXIN1 CDK4 CTNNB1 DES GPC3 KIT
6 embryo MP:0005380 10.18 AXIN1 CDK4 CTNNB1 GPC3 KIT MDM2
7 integument MP:0010771 10.15 CDK4 CTNNB1 GPC3 KIT MDM2 MYOG
8 muscle MP:0005369 10.11 CDK4 CTNNB1 DES KIT MDM2 MYOD1
9 normal MP:0002873 10.11 AXIN1 CDK4 CTNNB1 KIT MDM2 MKI67
10 craniofacial MP:0005382 10.09 AXIN1 CDK4 CTNNB1 GPC3 KIT MDM2
11 digestive/alimentary MP:0005381 10.08 AXIN1 CDK4 CTNNB1 GPC3 KIT MDM2
12 no phenotypic analysis MP:0003012 9.95 CTNNB1 KIT MDM2 MKI67 MYOD1 MYOG
13 neoplasm MP:0002006 9.91 CDK4 CTNNB1 KIT MDM2 MYOD1 TP53
14 reproductive system MP:0005389 9.85 AXIN1 CDK4 CTNNB1 GPC3 KIT MDM2
15 pigmentation MP:0001186 9.8 CDK4 CTNNB1 GPC3 KIT MDM2 TP53
16 renal/urinary system MP:0005367 9.8 AXIN1 CDK4 CTNNB1 GPC3 KIT MDM2
17 respiratory system MP:0005388 9.56 AXIN1 CTNNB1 GPC3 KIT MYOD1 MYOG
18 skeleton MP:0005390 9.28 AXIN1 CDK4 CTNNB1 GPC3 KIT MDM2

Drugs & Therapeutics for Embryonal Sarcoma

Drugs for Embryonal Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sargramostim Approved, Investigational Phase 3 123774-72-1, 83869-56-1
2
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
3
Lenograstim Approved, Investigational Phase 3 135968-09-1
4
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
5
Dactinomycin Approved, Investigational Phase 3 50-76-0 2019 457193
6
Molgramostim Investigational Phase 3 99283-10-0
7 Anti-Infective Agents Phase 3
8 Tubulin Modulators Phase 3
9 Antirheumatic Agents Phase 3
10 Immunosuppressive Agents Phase 3
11 Antimitotic Agents Phase 3
12 Alkylating Agents Phase 3
13 Immunologic Factors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Actinomycin D and Vincristine With or Without Radiation Therapy, for Newly Diagnosed Patients With Low-Risk Rhabdomyosarcoma or Undifferentiated Sarcoma: IRS-V Protocol Completed NCT00002995 Phase 3 cyclophosphamide;vincristine sulfate
2 A Phase I Study of Doxorubicin and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and Intraoperative Brachytherapy for Unresectable or Refractory Pelvic and Abdominal Rhabdomyosarcoma and Undifferentiated Sarcomas in Children Withdrawn NCT03111069 Phase 1 Doxorubicin
3 Observational - SNP Array Analysis of Undifferentiated Sarcomas Completed NCT01802125

Search NIH Clinical Center for Embryonal Sarcoma

Genetic Tests for Embryonal Sarcoma

Anatomical Context for Embryonal Sarcoma

MalaCards organs/tissues related to Embryonal Sarcoma:

40
Liver, Bone, Prostate, Breast, Heart, Uterus, Smooth Muscle

Publications for Embryonal Sarcoma

Articles related to Embryonal Sarcoma:

(show top 50) (show all 883)
# Title Authors PMID Year
1
B-Mode and Contrast Enhanced Ultrasonography Features of Gastric Inflammatory and Neoplastic Diseases in Dogs. 61
33802392 2021
2
Chemotherapy and targeted treatments of breast sarcoma by histologic subtype. 61
33554686 2021
3
Undifferentiated embryonal sarcoma of the liver: A rare hepatic tumor and its related characteristic radiological features. 61
33488891 2021
4
Partial Gastrectomy at the Time of Splenectomy in Two Dogs With Splenic Neoplasia and Gastric Involvement. 61
33115688 2021
5
Non-rhabdomyosarcoma soft tissue sarcomas diagnosed in patients at a young age. An overview of clinical, pathological, and molecular findings. 61
33764675 2021
6
Humeral Shaft Fracture With Placement of an Intramedullary Nail Through an Unrecognized Sarcoma. 61
33620175 2021
7
Congenital Suborbital Undifferentiated Sarcoma in a Crossbred Calf. 61
33670814 2021
8
Undifferentiated embryonal sarcoma of the liver presenting as a hemorrhagic mass in a pregnant woman. 61
33640792 2021
9
Liver Transplantation in Locally Unresectable, Undifferentiated Embryonal Cell Sarcoma. 61
33490379 2021
10
Tumor Embolism as a Cause of Renal Artery Occlusion and Acute Kidney Injury Diagnosed and Treated with Endovascular Intervention in a Patient with Mediastinal Undifferentiated Sarcoma. 61
33456039 2021
11
Cytology of SMARCA4-Deficient Thoracic Neoplasms: Comparative Analysis of SMARCA4-Deficient Non-Small Cell Lung Carcinomas and SMARCA4-Deficient Thoracic Sarcomas. 61
32854100 2021
12
H3F3A G34 mutation DNA sequencing and G34W immunohistochemistry analysis in 366 cases of giant cell tumors of bone and other bone tumors. 61
33021329 2021
13
Mesenchymal hamartoma and undifferentiated embryonal sarcoma: diagnostic keys that radiologists need to know. 61
33187686 2021
14
Canine tonsillar neoplasia and tonsillar metastasis from various primary neoplasms. 61
32352191 2020
15
[Radiation-Induced Undifferentiated Pleomorphic Sarcoma after Breast-Conserving Surgery-A Case Report]. 61
33468896 2020
16
Basaloid squamous cell carcinoma of the uterine cervix coexisting with undifferentiated sarcoma. 61
33488332 2020
17
Undifferentiated sarcoma of the liver: Multicenter international experience of the Cooperative Soft-Tissue Sarcoma Group and Polish Paediatric Solid Tumor Group. 61
32706511 2020
18
Brain Radionecrosis After Adjuvant Radiation Therapy for a Primary Intracerebral Undifferentiated Sarcoma. 61
32763370 2020
19
Adjuvant Maintenance Larotrectinib Therapy in 2 Children With NTRK Fusion-positive High-grade Cancers. 61
33093355 2020
20
Primary Atrial Undifferentiated Sarcoma Found on FDG PET/CT Mimicking Cardiac Myxoma. 61
32804771 2020
21
Undifferentiated Embryonal Sarcoma of the Liver Identified after the Initial Diagnosis of a Hepatic Cyst. 61
32611966 2020
22
Undifferentiated embryonal sarcoma of the liver in adults: Retrospective analysis of a case series and systematic review. 61
32831921 2020
23
Undifferentiated embryonal sarcoma of the liver: Clinical characteristics and outcomes. 61
33195644 2020
24
Long-term survival outcomes of undifferentiated embryonal sarcoma of the liver: a pooled analysis of 308 patients. 61
31957153 2020
25
Surgical management of large undifferentiated cardiac sarcoma involving the right ventricle to pulmonary trunk. 61
31541347 2020
26
Clinicopathological findings of pediatric NTRK fusion mesenchymal tumors. 61
32957984 2020
27
Immunohistochemical markers and the clinical course of adenosarcoma: a series of seven cases. 61
32972432 2020
28
Primary Retrobulbar Leiomyosarcoma in a Dog: A Case Report. 61
32992611 2020
29
Differentiation of soft-tissue lymphoma from undifferentiated sarcoma: apparent diffusion coefficient histogram analysis. 61
32847366 2020
30
[Development of sarcoma on a ectopic extramedullary hematopoiesis secondary to hereditary spherocytosis: Case report and literature review]. 61
32712043 2020
31
Negative MAPK-ERK regulation sustains CIC-DUX4 oncoprotein expression in undifferentiated sarcoma. 61
32788348 2020
32
Incidence, treatment, and outcomes of primary and recurrent Non-Wilms renal tumors in children: Report of 109 patients treated at a single institution. 61
32620510 2020
33
Undifferentiated embryonal sarcoma of liver: Paradoxical imaging appearance. 61
32489512 2020
34
Tumor-induced osteomalacia in an adolescent with an undifferentiated embryonal sarcoma of the liver. 61
32383825 2020
35
Treatment of Hepatic Embryonal Undifferentiated Sarcoma With Cardiothoracic Involvement. 61
30319025 2020
36
Primary bone sarcoma with BCOR internal tandem duplication. 61
31900635 2020
37
A splenic 'cyst': histology confirmed splenic sarcoma. 61
32233844 2020
38
Primary paediatric chest wall tumours necessitating surgical management. 61
32159373 2020
39
Management of Unresectable Metastatic Primitive Myxoid Mesenchymal Tumor of Infancy: A Case Report and Systematic Review of the Literature. 61
32118811 2020
40
Unusual Behaviour Of A Lung Inflammatory Myofibroblastic Tumour. 61
32707622 2020
41
The genomics of undifferentiated sarcoma of soft tissue: Progress, challenges and opportunities. 61
31866474 2020
42
The genomic landscape of undifferentiated embryonal sarcoma of the liver is typified by C19MC structural rearrangement and overexpression combined with TP53 mutation or loss. 61
32310940 2020
43
Craniofacial second primary tumors in patients with germline retinoblastoma previously treated with external beam radiotherapy: A retrospective institutional analysis. 61
31904159 2020
44
Hepatic mesenchymal hamartoma and undifferentiated embryonal sarcoma of the liver: a pathologic review. 61
32647564 2020
45
Liver Transplantation for Pediatric Liver Cancer. 61
32204368 2020
46
DNA Methylation Profiling for Diagnosing Undifferentiated Sarcoma with Capicua Transcriptional Receptor (CIC) Alterations. 61
32155762 2020
47
Pathologic fracture healing after femoral limb salvage in a dog. 61
31792933 2020
48
Incidence and long-term outcomes of surgically treated childhood hepatic malignancies in Finland. 61
31350767 2020
49
Sarcoma undifferentiated (unclassified) fusiform cell type of mesentery: a case report and literature review. 61
32537062 2020
50
Undifferentiated embryonal sarcoma of the liver treated with associating liver partition and portal vein ligation for staged hepatectomy in a young adult: A case report. 61
31874380 2020

Variations for Embryonal Sarcoma

Expression for Embryonal Sarcoma

Search GEO for disease gene expression data for Embryonal Sarcoma.

Pathways for Embryonal Sarcoma

Pathways related to Embryonal Sarcoma according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.75 TP53 MDM2 KIT CTNNB1 CDK4 AXIN1
2
Show member pathways
12.66 TP53 MDM2 CTNNB1 CDK4 AXIN1
3
Show member pathways
12.61 TP53 KIT CTNNB1 CDK4 AXIN1
4 12.36 TP53 MDM2 KIT CTNNB1 CDK4 AXIN1
5 12.24 VIM TP53 MKI67 MDM2 CDK4
6
Show member pathways
12.18 TP53 MDM2 CTNNB1 AXIN1
7 12.15 TP53 MDM2 GPC3 CTNNB1
8 12.05 VIM TP53 CTNNB1 CDK4 AXIN1
9 11.95 TP53 MDM2 CTNNB1 CDK4
10 11.71 TP53 MDM2 CDK4
11 11.68 TP53 MDM2 CTNNB1 AXIN1
12 11.63 VIM MKI67 CTNNB1
13 11.62 TP53 MDM2 CDK4
14 11.54 TP53 MDM2 CTNNB1 AXIN1
15
Show member pathways
11.46 MYOG MYOD1 CTNNB1
16 11.33 TP53 MDM2 CDK4
17 11.3 TP53 MDM2 CDK4
18 11.23 MYOG MYOD1 KIT DES
19 11.09 TP53 MDM2 CDK4
20 11.07 TP53 MDM2 CTNNB1 CDK4 AXIN1

GO Terms for Embryonal Sarcoma

Cellular components related to Embryonal Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.8 VIM TP53 SERPINA3 S100B PEG3 MYOG
2 beta-catenin destruction complex GO:0030877 9.26 CTNNB1 AXIN1
3 fascia adherens GO:0005916 9.16 DES CTNNB1
4 transcription factor complex GO:0005667 9.02 TP53 MYOG MYOD1 CTNNB1 CDK4

Biological processes related to Embryonal Sarcoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 10.07 TP53 PEG3 MYOG MYOD1 MDM2 KIT
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.02 TP53 PEG3 MYOG MYOD1 MDM2 CTNNB1
3 positive regulation of cell proliferation GO:0008284 9.88 S100B MDM2 KIT CTNNB1 CDK4
4 positive regulation of gene expression GO:0010628 9.83 VIM TP53 MDM2 KIT CTNNB1
5 response to drug GO:0042493 9.8 TP53 MDM2 CTNNB1 CDK4
6 regulation of cell proliferation GO:0042127 9.62 TP53 KIT CTNNB1 CDK4
7 cellular response to growth factor stimulus GO:0071363 9.58 MYOG MDM2 CTNNB1
8 regulation of gene expression GO:0010468 9.55 PEG3 MYOD1 MDM2 CTNNB1 CDK4
9 cardiac septum morphogenesis GO:0060411 9.54 TP53 MDM2
10 myotube differentiation GO:0014902 9.51 MYOG MYOD1
11 positive regulation of skeletal muscle fiber development GO:0048743 9.46 MYOG MYOD1
12 cellular response to UV-C GO:0071494 9.37 TP53 MDM2
13 muscle cell fate commitment GO:0042693 9.26 MYOG MYOD1
14 cellular response to actinomycin D GO:0072717 8.96 TP53 MDM2
15 positive regulation of muscle cell differentiation GO:0051149 8.92 MYOG MYOD1 MDM2 CTNNB1

Molecular functions related to Embryonal Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquitin protein ligase binding GO:0031625 9.56 TP53 MYOD1 MDM2 AXIN1
2 enzyme binding GO:0019899 9.35 TP53 MYOD1 MDM2 CTNNB1 AXIN1
3 proximal promoter sequence-specific DNA binding GO:0000987 9.33 TP53 MYOG MYOD1
4 I-SMAD binding GO:0070411 9.32 CTNNB1 AXIN1
5 disordered domain specific binding GO:0097718 8.8 TP53 MDM2 CTNNB1

Sources for Embryonal Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....