MCID: EMB006
MIFTS: 31

Embryonal Testis Carcinoma

Categories: Cancer diseases, Endocrine diseases, Fetal diseases, Reproductive diseases

Aliases & Classifications for Embryonal Testis Carcinoma

MalaCards integrated aliases for Embryonal Testis Carcinoma:

Name: Embryonal Testis Carcinoma 12 15
Testicular Embryonal Carcinoma 12 17 70
Embryonal Carcinoma of the Testis 12
Embryonal Carcinoma of Testis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5680
NCIt 50 C6341
UMLS 70 C0238448

Summaries for Embryonal Testis Carcinoma

Disease Ontology : 12 An embryonal carcinoma that is located in the testis.

MalaCards based summary : Embryonal Testis Carcinoma, also known as testicular embryonal carcinoma, is related to intratubular embryonal carcinoma and mature teratoma. An important gene associated with Embryonal Testis Carcinoma is PICSAR (P38 Inhibited Cutaneous Squamous Cell Carcinoma Associated LincRNA). The drugs Palivizumab and Ribavirin have been mentioned in the context of this disorder. Affiliated tissues include testis, bone marrow and bone.

Related Diseases for Embryonal Testis Carcinoma

Diseases related to Embryonal Testis Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 intratubular embryonal carcinoma 32.0 TNFRSF8 AFP
2 mature teratoma 29.8 TNFRSF8 AFP
3 childhood embryonal testis carcinoma 11.5
4 embryonal carcinoma 10.6
5 male infertility 10.3
6 seminoma 10.3
7 teratoma 10.2
8 choriocarcinoma 10.2
9 hyperthyroidism 10.2
10 germ cells tumors 10.2
11 testicular germ cell tumor 10.2
12 infertility 10.2
13 spermatogenic failure, x-linked, 1 10.2 SEPTIN12 LRWD1 EPPIN
14 hydrocele 10.2 EPPIN AFP
15 ovarian solid teratoma 10.1 TNFRSF8 AFP
16 intermediate malignant teratoma 10.1 TNFRSF8 AFP
17 malignant teratoma 10.1 TNFRSF8 AFP
18 spermatogenic failure 50 10.1 TNP2 SEPTIN12 EPPIN
19 teratocarcinoma 10.1
20 ovarian embryonal carcinoma 10.1 TNFRSF8 AFP
21 testicular infarct 10.1 TNFRSF8 AFP
22 infected hydrocele 10.1 TNFRSF8 AFP
23 mixed germ cell cancer 10.1 TNFRSF8 AFP
24 intussusception 10.1
25 cystic fibrosis 10.1
26 infective endocarditis 10.1
27 in situ carcinoma 10.1
28 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.1
29 nonseminomatous germ cell tumor 10.1
30 epididymo-orchitis 10.1 TNP2 AFP
31 testicular malignant germ cell cancer 10.1 TNFRSF8 AFP
32 ovarian benign neoplasm 10.1 EPPIN AFP
33 ovarian gonadoblastoma 10.0 TNFRSF8 AFP
34 urethral stricture 10.0
35 endodermal sinus tumor 10.0
36 testicular cancer 10.0
37 testicular yolk sac tumor 10.0
38 epididymis disease 10.0 EPPIN AFP
39 mediastinal cancer 10.0 TNFRSF8 AFP
40 testicular disease 10.0 TNFRSF8 EPPIN AFP
41 retinoblastoma 10.0
42 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.0
43 hypogonadotropic hypogonadism 10.0
44 infant gynecomastia 10.0
45 gynecomastia 10.0
46 heart septal defect 10.0
47 atrial heart septal defect 10.0
48 brain germinoma 10.0
49 germinoma 10.0
50 central nervous system germinoma 10.0

Graphical network of the top 20 diseases related to Embryonal Testis Carcinoma:



Diseases related to Embryonal Testis Carcinoma

Symptoms & Phenotypes for Embryonal Testis Carcinoma

Drugs & Therapeutics for Embryonal Testis Carcinoma

Drugs for Embryonal Testis Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Palivizumab Approved, Investigational Phase 3 188039-54-5
2
Ribavirin Approved Phase 3 36791-04-5 37542
3
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
4
Captopril Approved Phase 3 62571-86-2 44093
5
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
6
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
7
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
8
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 468682 2826718
9
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
10
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
11
Etoposide Approved Phase 3 33419-42-0 36462
12
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
13
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 6857599 43805
14
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
15
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
16
Vinblastine Approved Phase 3 865-21-4 13342 241903
17
Ifosfamide Approved Phase 3 3778-73-2 3690
18 Immunoglobulins Phase 3
19 Anti-Infective Agents Phase 3
20 Antimetabolites Phase 3
21 Antibodies Phase 3
22 Antiviral Agents Phase 3
23 Antibodies, Monoclonal Phase 3
24 Antirheumatic Agents Phase 3
25 Angiotensin-Converting Enzyme Inhibitors Phase 3
26 Antihypertensive Agents Phase 3
27 HIV Protease Inhibitors Phase 3
28
protease inhibitors Phase 3
29 Hormones Phase 3
30 Hormone Antagonists Phase 3
31 Liver Extracts Phase 3
32 Liposomal amphotericin B Phase 3
33 Antiparasitic Agents Phase 3
34 Antifungal Agents Phase 3
35 Antiprotozoal Agents Phase 3
36 Amebicides Phase 3
37 Cytochrome P-450 CYP3A Inhibitors Phase 3
38
Hydroxyitraconazole Phase 3 108222
39 Cytochrome P-450 Enzyme Inhibitors Phase 3
40 Etoposide phosphate Phase 3
41 Antibiotics, Antitubercular Phase 3
42 Anti-Bacterial Agents Phase 3
43 Tubulin Modulators Phase 3
44
Isophosphamide mustard Phase 3 100427
45 Alkylating Agents Phase 3
46 Antimitotic Agents Phase 3
47 Albumin-Bound Paclitaxel Phase 3
48
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
49
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
50
Oprelvekin Approved, Investigational Phase 2 145941-26-0

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Randomized Phase II/III Study of Taxol/Paclitaxel-BEP Versus BEP in Patients With Intermediate Prognosis Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 A Randomized Double-Blind Placebo-Controlled Phase III Study To Evaluate The Safety And Efficacy Of Palivizumab Combined With Aerosolized Ribavirin Compared To Ribavirin Alone To Treat RSV Pneumonia In Patients With Bone Marrow Transplants (BMT) Completed NCT00014391 Phase 3 ribavirin
3 Phase III Study of Captopril in Patients Undergoing Autologous Bone Marrow/Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
4 RANDOMIZED MULTIINSTITUTIONAL PHASE III TRIAL OF BEP AND HIGH DOSE CHEMOTHERAPY VERSUS BEP ALONE IN PREVIOUSLY UNTREATED PATIENTS WITH POOR RISK GERM CELL TUMORS Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
5 A Randomized Phase III Study of Sequential High-Dose Cisplatinum/Etoposide/Ifosfamide Plus Stem Cell Support Versus BEP in Patients With Poor Prognosis Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
6 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
7 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
8 A Randomized, Comparative Study of Itraconazole Versus Fluconazole for Prevention of Aspergillus Infections in Peripheral Blood Stem Cell and Marrow Transplant Recipients Completed NCT00003883 Phase 3 fluconazole;itraconazole
9 A Risk-Adapted Strategy of the Use of Dose-Dense Chemotherapy in Patients With Poor-Prognosis Disseminated Non-Seminomatous Germ Cell Tumors Active, not recruiting NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
10 A Randomized Phase III Study of Paclitaxel, Ifosfamide and Cisplatin Versus Vinblastine, Ifosfamide and Cisplatin as Second-Line Therapy for Patients With Relapsed/Resistant Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
11 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
12 Accelerated BEP Chemotherapy for Intermediate and High Risk Metastatic Germ Cell Tumor Completed NCT00453232 Phase 2 cisplatin;etoposide
13 A Phase II Study of BMS-247550 In Advanced Germ Cell Tumor Patients - THERAPEUTIC/DIAGNOSTIC PROTOCOL Completed NCT00070096 Phase 2 ixabepilone
14 Tandem High-Dose Chemotherapy With Autologous Stem Cell Rescue for Poor-Prognosis Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
15 A PHASE II STUDY OF CELLULAR ADOPTIVE IMMUNOTHERAPY AS PROPHYLAXIS FOR CYTOMEGALOVIRUS DISEASE AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION Completed NCT00002673 Phase 2
16 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
17 Randomized Phase II Trial of Intensive Induction Chemotherapy (CBOP/BEP) and Standard BEP Chemotherapy in Poor Prognosis Male Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
18 Oral Beclomethasone Dipropionate Capsules for Treatment of Intestinal Graft-Versus-Host Disease: Compassionate Use in Patients With Contraindictions to High-Dose Immunosuppressive Therapy Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
19 Combination of Interleukin 11 (Neumega) With G-CSF to Mobilize Autologous Peripheral Blood Stem Cells (PBSC) Completed NCT00004157 Phase 2
20 Donor Lymphocyte Infusion (DLI) as Adoptive Immunotherapy for Relapse Malignancies After Allogeneic Hematopoietic Transplantation Completed NCT00003887 Phase 2
21 Cytokine-Based Immunotherapy Following High-Dose Chemotherapy and Autologous Stem Cell Transplantation Completed NCT00003408 Phase 2
22 A Study of Paclitaxel, Cisplatin and Ifosfamide as Induction Therapy in the Treatment of Patients Relapsing After BEP Chemotherapy for Metastatic Germ Cell Tumors Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
23 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Active, not recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
24 A Phase I Trial of Recombinant Human Interleukin-12 After High-Dose Therapy and Autologous Hematopoietic Stem Cell Support Completed NCT00003107 Phase 1
25 A Randomized, Placebo-Controlled, Blinded Study Of Acupuncture Therapy In Mucositis-Related Pain In Patients Undergoing Hematopoietic Stem Cell Transplantation Completed NCT00060021
26 Correlation of Histopathology, Immunohistochemistry and Quantitative Radiology With Outcome in Early Stage Nonseminomatous Germ Cell Tumor Completed NCT00003800
27 A Study Of 18 FDG PET In The Prediction Of Relapse In Patients With A Clinical Stage I Non-Seminomatous Germ Cell Tumor Completed NCT00045045
28 Multi-Site Randomized Clinical Trial Comparing Standard Recovery Preparation to Extended Recovery Preparation to Enhance Long Term Function After Marrow or Stem Cell Transplant Completed NCT00049465

Search NIH Clinical Center for Embryonal Testis Carcinoma

Genetic Tests for Embryonal Testis Carcinoma

Anatomical Context for Embryonal Testis Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Embryonal Testis Carcinoma:

19
Testis

MalaCards organs/tissues related to Embryonal Testis Carcinoma:

40
Testis, Bone Marrow, Bone, Heart, Lymph Node, Spinal Cord, Pineal

Publications for Embryonal Testis Carcinoma

Articles related to Embryonal Testis Carcinoma:

(show top 50) (show all 83)
# Title Authors PMID Year
1
Subcapsular urinoma following metastasis of testicular embryonal carcinoma. 61
33680854 2021
2
Pulmonary metastasis: very late relapse of testicular embryonal carcinoma. 61
32268717 2020
3
A case of contralateral superficial inguinal recurrence of testicular embryonal carcinoma. 61
31641597 2019
4
Long noncoding RNA HOTTIP is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation. 61
31328440 2019
5
Benzothiazole carbamates and amides as antiproliferative species. 61
30179747 2018
6
Challenges and Role Changes in Caring for Adult Children With Cancer. 61
31186984 2018
7
Imsnc761 and DDX6 synergistically suppress cell proliferation and promote apoptosis via p53 in testicular embryonal carcinoma cells. 61
29769412 2018
8
Hsa-miR-513b-5p suppresses cell proliferation and promotes P53 expression by targeting IRF2 in testicular embryonal carcinoma cells. 61
28512062 2017
9
Expression of neural cell adhesion molecule L1 (CD171) in neuroectodermal and other tumors: An immunohistochemical study of 5155 tumors and critical evaluation of CD171 prognostic value in gastrointestinal stromal tumors. 61
27419370 2016
10
[Intracranial remote epidural haematoma as a complication after resection of an occipital lobe metastatic tumour from a testicular embryonal carcinoma – a case report]. 61
29533594 2016
11
Hypermethylation of genes in testicular embryonal carcinomas. 61
26625006 2016
12
Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-β/δ- and retinoic acid receptor-dependent mechanisms. 61
26431381 2015
13
Downregulation of miR-320a/383-sponge-like long non-coding RNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation. 61
26539909 2015
14
[THREE CASE REPORTS OF METACHRONOUS BILATERAL TESTICULAR TUMOR: INVESTIGATION OF SEXUAL FUNCTION AND FERTILITY]. 61
26419079 2015
15
[Chylous asctites post abdominal laparotomy; revision and report of a case]. 61
25795983 2015
16
Canine testicular tumors: two types of seminomas can be differentiated by immunohistochemistry. 61
25096628 2014
17
Testicular embryonal carcinoma: a morphologic study of 180 cases highlighting unusual and unemphasized aspects. 61
24503753 2014
18
microRNA-383 impairs phosphorylation of H2AX by targeting PNUTS and inducing cell cycle arrest in testicular embryonal carcinoma cells. 61
24462707 2014
19
Cisplatin induces resistance by triggering differentiation of testicular embryonal carcinoma cells. 61
24475288 2014
20
Gonadotrophin-independent precocious puberty associated with later diagnosis of testicular embryonal carcinoma. 61
25012595 2014
21
MicroRNA-302a sensitizes testicular embryonal carcinoma cells to cisplatin-induced cell death. 61
23625774 2013
22
A human pluripotent carcinoma stem cell-based model for in vitro developmental neurotoxicity testing: effects of methylmercury, lead and aluminum evaluated by gene expression studies. 61
23501475 2013
23
Plerixafor and autologous stem cell transplantation: impressive result in a chemoresistant testicular cancer patient treated with high-dose chemotherapy. 61
23698254 2013
24
The targeting and functions of miRNA-383 are mediated by FMRP during spermatogenesis. 61
23640459 2013
25
Embyronal carcinoma of testis metastatic to ciliary body presenting as spontaneous hyphema and painful secondary glaucoma. 61
25390537 2013
26
Transcription factors Sp1 and p73 control the expression of the proapoptotic protein NOXA in the response of testicular embryonal carcinoma cells to cisplatin. 61
22718761 2012
27
A case of hereditary persistence of α-fetoprotein: diagnostic usefulness of the subfraction profile. 61
22689918 2012
28
Mono-(2-ethylhexyl) phthalate (MEHP) promotes invasion and migration of human testicular embryonal carcinoma cells. 61
22321834 2012
29
Minimum regions of genomic imbalance in stage I testicular embryonal carcinoma and association of 22q loss with relapse. 61
21213372 2011
30
Downregulation of microRNA-383 is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation by targeting IRF1. 61
21368870 2010
31
Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer. 61
20811155 2010
32
Screening for germline DND1 mutations in testicular cancer patients. 61
20411342 2010
33
MdmX is a substrate for the deubiquitinating enzyme USP2a. 61
19838211 2010
34
[Identification of human testicular embryonal carcinoma proteins by two-dimensional gel electrophoresis and mass spectrometry]. 61
19726299 2009
35
Non-palpable testicular embryonal carcinoma diagnosed by ultrasound: a case report. 61
19066212 2009
36
Testicular embryonal carcinoma presenting as chest wall subcutaneous mass. 61
21938149 2009
37
Spontaneous regression of pulmonary metastases from testicular embryonal carcinoma. 61
18304227 2008
38
Identification of an OCT4 and SRY regulatory module using integrated computational and experimental genomics approaches. 61
17567999 2007
39
Four pregnancies and two deliveries after unilateral orchidectomy and chemotherapy for testicular embryonal carcinoma. 61
16211371 2005
40
Tissue specificity of enhancer and promoter activities of a HERV-K(HML-2) LTR. 61
15177887 2004
41
Development of human chorionic gonadotropin subunit-beta promoter-based toxic gene therapy for testicular cancer. 61
15028478 2004
42
Testicular embryonal carcinoma metastatic to the labial mucosa of the upper lip. 61
11337274 2001
43
[Testicular embryonal carcinoma with contralateral synchronous intratubular germ cell neoplasia: analysis of a case]. 61
11011433 2000
44
Five different anti-prostate-specific membrane antigen (PSMA) antibodies confirm PSMA expression in tumor-associated neovasculature. 61
10397265 1999
45
[Platinum-based chemotherapy in renal transplant recipients with malignancies: a case report and review of literature]. 61
10101481 1998
46
Localization of the cellular expression of inhibin in trophoblastic tissue. 61
9568511 1998
47
Fluorescence in situ hybridization on nuclei from paraffin-embedded tissue in low stage pure embryonal carcinoma of the testis. 61
9400488 1998
48
Isochromosome 12p and maternal loss of 1p36 in a pediatric testicular germ cell tumor. 61
8944752 1996
49
Induction of mcl1/EAT, Bcl-2 related gene, by retinoic acid or heat shock in the human embryonal carcinoma cells, NCR-G3. 61
8790944 1996
50
Heat shock induces differentiation of human embryonal carcinoma cells into trophectoderm lineages. 61
8612676 1996

Variations for Embryonal Testis Carcinoma

Expression for Embryonal Testis Carcinoma

Search GEO for disease gene expression data for Embryonal Testis Carcinoma.

Pathways for Embryonal Testis Carcinoma

GO Terms for Embryonal Testis Carcinoma

Sources for Embryonal Testis Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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