MCID: EMB006
MIFTS: 34

Embryonal Testis Carcinoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases, Fetal diseases

Aliases & Classifications for Embryonal Testis Carcinoma

MalaCards integrated aliases for Embryonal Testis Carcinoma:

Name: Embryonal Testis Carcinoma 12 15
Testicular Embryonal Carcinoma 12 73
Embryonal Carcinoma of the Testis 12
Embryonal Carcinoma of Testis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5680
NCIt 50 C6341
UMLS 73 C0238448

Summaries for Embryonal Testis Carcinoma

Disease Ontology : 12 An embryonal carcinoma that is located in the testis.

MalaCards based summary : Embryonal Testis Carcinoma, also known as testicular embryonal carcinoma, is related to intratubular embryonal carcinoma and childhood embryonal testis carcinoma. An important gene associated with Embryonal Testis Carcinoma is PICSAR (P38 Inhibited Cutaneous Squamous Cell Carcinoma Associated LincRNA
NLC1-C,also known as long intergenic non-protein-coding RNA162 (LINC00162),was down-regulated in the cytoplasm and accumulated in the nucleus of spermatogonia and primary spermatocytes in the testes of infertile men with mixed patterns of MA compared with normal control. The accumulation of NLC1-C in the nucleus repressed miR-320a and miR-383 transcript and promoted testicular embryonal carcinoma cell proliferation by binding to Nucleolin.
Dysfunction Pattern: Regulation [down-regulated]), and among its related pathways/superpathways is Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Lenograstim and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include the testis, testis and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Embryonal Testis Carcinoma

Graphical network of the top 20 diseases related to Embryonal Testis Carcinoma:



Diseases related to Embryonal Testis Carcinoma

Symptoms & Phenotypes for Embryonal Testis Carcinoma

GenomeRNAi Phenotypes related to Embryonal Testis Carcinoma according to GeneCards Suite gene sharing:

26 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 10 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10 DDX6 PPP1R3A AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10 RNF168
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10 POU5F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10 POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10 PPP1R3A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10 PPP1R3A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10 RNF168
10 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10 RNF168
11 Increased shRNA abundance (Z-score > 2) GR00366-A-192 10 POU5F1 AFP
12 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10 RNF168
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10 AFP
14 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10 POU5F1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-44 10 DDX6
16 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10 RNF168
17 Increased shRNA abundance (Z-score > 2) GR00366-A-6 10 DDX6
18 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10 PPP1R3A AFP RNF168
19 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10 POU5F1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-76 10 RNF168
21 Increased shRNA abundance (Z-score > 2) GR00366-A-8 10 PPP1R3A
22 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10 PPP1R3A
23 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10 DDX6 PPP1R3A
24 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10 PPP1R3A

Drugs & Therapeutics for Embryonal Testis Carcinoma

Drugs for Embryonal Testis Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 91)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
2
Etoposide Approved Phase 2, Phase 3,Phase 3 33419-42-0 36462
3
Cisplatin Approved Phase 2, Phase 3,Phase 3,Phase 1 15663-27-1 84093 441203 2767
4
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
5
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
6
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 43805 6857599
7
Paclitaxel Approved, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1 33069-62-4 36314
8
Bleomycin Approved, Investigational Phase 2, Phase 3,Phase 3 11056-06-7 5360373
9
Ribavirin Approved Phase 3 36791-04-5 37542
10
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
11
Captopril Approved Phase 3 62571-86-2 44093
12
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
13
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
14
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
15
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
16
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
17
Palivizumab Approved, Investigational Phase 3 188039-54-5
18
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
19
Vinblastine Approved Phase 3 865-21-4 13342 241903
20
Isophosphamide mustard Phase 3,Phase 1,Phase 2 0
21 Alkylating Agents Phase 3,Phase 1,Phase 2
22 Albumin-Bound Paclitaxel Phase 2, Phase 3,Phase 3,Phase 1
23 Topoisomerase Inhibitors Phase 2, Phase 3,Phase 3
24 Anti-Bacterial Agents Phase 2, Phase 3,Phase 3
25 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 3
26 Etoposide phosphate Phase 2, Phase 3,Phase 3
27 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
28 Anti-Infective Agents Phase 3,Phase 1,Phase 2
29 Antimetabolites Phase 3,Phase 1,Phase 2
30 Antiviral Agents Phase 3,Phase 1,Phase 2
31 Antimitotic Agents Phase 2, Phase 3,Phase 3,Phase 1
32 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2
33 Antineoplastic Agents, Phytogenic Phase 2, Phase 3,Phase 3,Phase 1
34
Hydroxyitraconazole Phase 3
35
protease inhibitors Phase 3
36 Steroid Synthesis Inhibitors Phase 3
37 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
38 Cytochrome P-450 CYP3A Inhibitors Phase 3
39 HIV Protease Inhibitors Phase 3
40 Cytochrome P-450 Enzyme Inhibitors Phase 3
41 Hormone Antagonists Phase 3,Phase 1,Phase 2
42 Hormones Phase 3,Phase 1,Phase 2
43 Angiotensin-Converting Enzyme Inhibitors Phase 3
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
45 Echinocandins Phase 3
46 Antibodies Phase 3,Phase 1
47 Immunoglobulins Phase 3,Phase 1
48 Antibodies, Monoclonal Phase 3,Phase 1
49 Antihypertensive Agents Phase 3
50 Antifungal Agents Phase 3

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
3 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
4 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
5 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
6 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
7 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
8 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
9 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
10 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
11 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
12 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
13 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
14 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 paclitaxel;carboplatin;ifosfamide
15 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
16 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
17 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
18 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
19 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
20 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
21 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
22 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
23 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
24 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
25 Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
26 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
27 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
28 MEN-10755 in Treating Patients With Solid Tumors Completed NCT00003982 Phase 1 sabarubicin
29 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
30 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
31 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021 Not Applicable
32 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465 Not Applicable
33 Positron Emission Tomography in Detecting Testicle Cancer Completed NCT00045045 Not Applicable
34 Diagnostic Study of Patients With Stage I Testicular Cancer Completed NCT00003800 Not Applicable
35 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Recruiting NCT01434355

Search NIH Clinical Center for Embryonal Testis Carcinoma

Genetic Tests for Embryonal Testis Carcinoma

Anatomical Context for Embryonal Testis Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Embryonal Testis Carcinoma:

19
The Testis

MalaCards organs/tissues related to Embryonal Testis Carcinoma:

41
Testis, Bone Marrow, Bone, Breast, Colon, Liver, Small Intestine

Publications for Embryonal Testis Carcinoma

Articles related to Embryonal Testis Carcinoma:

(show all 13)
# Title Authors Year
1
Imsnc761 and DDX6 synergistically suppress cell proliferation and promote apoptosis via p53 in testicular embryonal carcinoma cells. ( 29769412 )
2018
2
Hsa-miR-513b-5p suppresses cell proliferation and promotes P53 expression by targeting IRF2 in testicular embryonal carcinoma cells. ( 28512062 )
2017
3
Downregulation of miR-320a/383-sponge-like long non-coding RNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation. ( 26539909 )
2015
4
Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-I^/I'- and retinoic acid receptor-dependent mechanisms. ( 26431381 )
2015
5
Gonadotrophin-independent precocious puberty associated with later diagnosis of testicular embryonal carcinoma. ( 25012595 )
2014
6
microRNA-383 impairs phosphorylation of H2AX by targeting PNUTS and inducing cell cycle arrest in testicular embryonal carcinoma cells. ( 24462707 )
2014
7
MicroRNA-302a sensitizes testicular embryonal carcinoma cells to cisplatin-induced cell death. ( 23625774 )
2013
8
Transcription factors Sp1 and p73 control the expression of the proapoptotic protein NOXA in the response of testicular embryonal carcinoma cells to cisplatin. ( 22718761 )
2012
9
Downregulation of microRNA-383 is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation by targeting IRF1. ( 21368870 )
2010
10
Non-palpable testicular embryonal carcinoma diagnosed by ultrasound: a case report. ( 19066212 )
2009
11
Down's syndrome associated with intracranial germinoma and testicular embryonal carcinoma. ( 8533196 )
1995
12
Metastatic mature teratoma in lung following testicular embryonal carcinoma and teratocarcinoma. ( 8135909 )
1993
13
Differentiation of human testicular embryonal carcinoma and teratocarcinoma grown in nude mice and soft-agar cultures. ( 6535649 )
1984

Variations for Embryonal Testis Carcinoma

Expression for Embryonal Testis Carcinoma

Search GEO for disease gene expression data for Embryonal Testis Carcinoma.

Pathways for Embryonal Testis Carcinoma

Pathways related to Embryonal Testis Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.75 AFP POU5F1

GO Terms for Embryonal Testis Carcinoma

Biological processes related to Embryonal Testis Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene silencing by miRNA GO:0060965 8.62 DND1 POU5F1

Molecular functions related to Embryonal Testis Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 miRNA binding GO:0035198 8.62 DND1 POU5F1

Sources for Embryonal Testis Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....