MCID: EMB006
MIFTS: 36

Embryonal Testis Carcinoma

Categories: Cancer diseases, Endocrine diseases, Fetal diseases, Reproductive diseases

Aliases & Classifications for Embryonal Testis Carcinoma

MalaCards integrated aliases for Embryonal Testis Carcinoma:

Name: Embryonal Testis Carcinoma 12 15
Testicular Embryonal Carcinoma 12 17 74
Embryonal Carcinoma of the Testis 12
Embryonal Carcinoma of Testis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5680
NCIt 51 C6341
UMLS 74 C0238448

Summaries for Embryonal Testis Carcinoma

Disease Ontology : 12 An embryonal carcinoma that is located in the testis.

MalaCards based summary : Embryonal Testis Carcinoma, also known as testicular embryonal carcinoma, is related to intratubular embryonal carcinoma and embryonal carcinoma. An important gene associated with Embryonal Testis Carcinoma is PICSAR (P38 Inhibited Cutaneous Squamous Cell Carcinoma Associated LincRNA), and among its related pathways/superpathways is Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Bleomycin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include testis, bone and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Embryonal Testis Carcinoma

Diseases related to Embryonal Testis Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 intratubular embryonal carcinoma 31.7 AFP POU5F1
2 embryonal carcinoma 30.5 AFP POU5F1
3 seminoma 29.8 AFP POU5F1
4 brain germinoma 29.7 AFP POU5F1
5 teratoma 29.6 AFP POU5F1
6 mature teratoma 29.6 AFP POU5F1
7 childhood embryonal testis carcinoma 12.6
8 testicular germ cell tumor 11.3
9 hyperthyroidism 10.1
10 male infertility 10.1
11 teratocarcinoma 10.1
12 infertility 10.1
13 intussusception 9.9
14 prostate cancer 9.9
15 cystic fibrosis 9.9
16 prostate cancer, hereditary, 8 9.9
17 salla disease 9.9
18 prostate cancer, hereditary, 6 9.9
19 leukemia 9.9
20 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 9.9
21 headache associated with sexual activity 9.9
22 endodermal sinus tumor 9.9
23 germinoma 9.9
24 narcolepsy 9.9
25 precocious puberty 9.9
26 extragonadal germ cell cancer 9.9 AFP POU5F1
27 germ cell cancer 9.9 AFP POU5F1
28 central nervous system germ cell tumor 9.9 AFP POU5F1
29 ovarian embryonal carcinoma 9.8 AFP POU5F1
30 malignant teratoma 9.8 AFP POU5F1
31 testicular infarct 9.8 AFP POU5F1
32 embryoma 9.8 AFP POU5F1
33 pineoblastoma 9.8 AFP POU5F1
34 mixed germ cell cancer 9.8 AFP POU5F1
35 extragonadal seminoma 9.7 AFP POU5F1
36 mixed cell type cancer 9.7 AFP POU5F1
37 germ cell and embryonal cancer 9.6 AFP POU5F1
38 testicular yolk sac tumor 9.5 AFP POU5F1

Graphical network of the top 20 diseases related to Embryonal Testis Carcinoma:



Diseases related to Embryonal Testis Carcinoma

Symptoms & Phenotypes for Embryonal Testis Carcinoma

GenomeRNAi Phenotypes related to Embryonal Testis Carcinoma according to GeneCards Suite gene sharing:

27 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.4 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.4 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.4 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.4 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.4 POU5F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.4 AFP POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.4 AFP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.4 POU5F1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.4 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.4 AFP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.4 POU5F1

Drugs & Therapeutics for Embryonal Testis Carcinoma

Drugs for Embryonal Testis Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 96)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bleomycin Approved, Investigational Phase 2, Phase 3,Phase 3 11056-06-7 5360373
2
Etoposide Approved Phase 2, Phase 3,Phase 3 33419-42-0 36462
3
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
4
Paclitaxel Approved, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1 33069-62-4 36314
5
Cisplatin Approved Phase 2, Phase 3,Phase 3,Phase 1 15663-27-1 2767 441203 84093
6
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
7
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
8
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 43805 6857599 5310940 9887054
9
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 38904 498142
10
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
11
Captopril Approved Phase 3 62571-86-2 44093
12
Ribavirin Approved Phase 3 36791-04-5 37542
13
Palivizumab Approved, Investigational Phase 3 188039-54-5
14
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
15
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
16
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
17
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 2826718 468682
18
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
19
Vinblastine Approved Phase 3 865-21-4 241903 13342
20 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 3
21 Antimitotic Agents Phase 2, Phase 3,Phase 3,Phase 1
22 Topoisomerase Inhibitors Phase 2, Phase 3,Phase 3
23 Etoposide phosphate Phase 2, Phase 3,Phase 3
24 Anti-Bacterial Agents Phase 2, Phase 3,Phase 3
25 Albumin-Bound Paclitaxel Phase 2, Phase 3,Phase 3,Phase 1
26 Antineoplastic Agents, Phytogenic Phase 2, Phase 3,Phase 3,Phase 1
27
Isophosphamide mustard Phase 3,Phase 1,Phase 2 0
28 Alkylating Agents Phase 3,Phase 1,Phase 2
29 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2
30 Immunologic Factors Phase 3,Phase 1,Phase 2
31 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
32 Antiviral Agents Phase 3,Phase 1,Phase 2
33 Anti-Infective Agents Phase 3,Phase 1,Phase 2
34 Antimetabolites Phase 3,Phase 1,Phase 2
35 Liver Extracts Phase 3
36 Antirheumatic Agents Phase 3
37 Antihypertensive Agents Phase 3
38 Angiotensin-Converting Enzyme Inhibitors Phase 3
39
protease inhibitors Phase 3
40 HIV Protease Inhibitors Phase 3
41 Antibodies, Monoclonal Phase 3,Phase 1
42 Antibodies Phase 3,Phase 1
43 Immunoglobulins Phase 3,Phase 1
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2
45 Hormone Antagonists Phase 3,Phase 1,Phase 2
46 Cytochrome P-450 CYP3A Inhibitors Phase 3
47 Cytochrome P-450 Enzyme Inhibitors Phase 3
48 Hormones Phase 3,Phase 1,Phase 2
49 Steroid Synthesis Inhibitors Phase 3
50 Cytochrome P-450 CYP2C9 Inhibitors Phase 3

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
3 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
4 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
5 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
6 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
7 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
8 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
9 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
10 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
11 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide;Etoposide Phosphate
12 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
13 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
14 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
15 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
16 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
17 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
18 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
19 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
20 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
21 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
22 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
23 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
24 Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
25 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
26 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
27 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
28 MEN-10755 in Treating Patients With Solid Tumors Completed NCT00003982 Phase 1 sabarubicin
29 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
30 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
31 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021 Not Applicable
32 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465 Not Applicable
33 Positron Emission Tomography in Detecting Testicle Cancer Completed NCT00045045 Not Applicable
34 Diagnostic Study of Patients With Stage I Testicular Cancer Completed NCT00003800 Not Applicable
35 DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Completed NCT01434355

Search NIH Clinical Center for Embryonal Testis Carcinoma

Genetic Tests for Embryonal Testis Carcinoma

Anatomical Context for Embryonal Testis Carcinoma

MalaCards organs/tissues related to Embryonal Testis Carcinoma:

42
Testis, Bone, Bone Marrow, Prostate, Liver, Colon, Small Intestine

The Foundational Model of Anatomy Ontology organs/tissues related to Embryonal Testis Carcinoma:

20
The Testis

Publications for Embryonal Testis Carcinoma

Articles related to Embryonal Testis Carcinoma:

(show all 34)
# Title Authors Year
1
Imsnc761 and DDX6 synergistically suppress cell proliferation and promote apoptosis via p53 in testicular embryonal carcinoma cells. ( 29769412 )
2018
2
Hsa-miR-513b-5p suppresses cell proliferation and promotes P53 expression by targeting IRF2 in testicular embryonal carcinoma cells. ( 28512062 )
2017
3
Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-β/δ- and retinoic acid receptor-dependent mechanisms. ( 26431381 )
2015
4
Downregulation of miR-320a/383-sponge-like long non-coding RNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation. ( 26539909 )
2015
5
microRNA-383 impairs phosphorylation of H2AX by targeting PNUTS and inducing cell cycle arrest in testicular embryonal carcinoma cells. ( 24462707 )
2014
6
Cisplatin induces resistance by triggering differentiation of testicular embryonal carcinoma cells. ( 24475288 )
2014
7
Testicular embryonal carcinoma: a morphologic study of 180 cases highlighting unusual and unemphasized aspects. ( 24503753 )
2014
8
Gonadotrophin-independent precocious puberty associated with later diagnosis of testicular embryonal carcinoma. ( 25012595 )
2014
9
MicroRNA-302a sensitizes testicular embryonal carcinoma cells to cisplatin-induced cell death. ( 23625774 )
2013
10
Mono-(2-ethylhexyl) phthalate (MEHP) promotes invasion and migration of human testicular embryonal carcinoma cells. ( 22321834 )
2012
11
Transcription factors Sp1 and p73 control the expression of the proapoptotic protein NOXA in the response of testicular embryonal carcinoma cells to cisplatin. ( 22718761 )
2012
12
Minimum regions of genomic imbalance in stage I testicular embryonal carcinoma and association of 22q loss with relapse. ( 21213372 )
2011
13
Downregulation of microRNA-383 is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation by targeting IRF1. ( 21368870 )
2010
14
Non-palpable testicular embryonal carcinoma diagnosed by ultrasound: a case report. ( 19066212 )
2009
15
Testicular embryonal carcinoma presenting as chest wall subcutaneous mass. ( 21938149 )
2009
16
Spontaneous regression of pulmonary metastases from testicular embryonal carcinoma. ( 18304227 )
2008
17
Four pregnancies and two deliveries after unilateral orchidectomy and chemotherapy for testicular embryonal carcinoma. ( 16211371 )
2005
18
Testicular embryonal carcinoma metastatic to the labial mucosa of the upper lip. ( 11337274 )
2001
19
Down's syndrome associated with intracranial germinoma and testicular embryonal carcinoma. ( 8533196 )
1995
20
MR findings of pineal yolk sac tumor in a patient with testicular embryonal carcinoma. ( 7922842 )
1994
21
Metastatic mature teratoma in lung following testicular embryonal carcinoma and teratocarcinoma. ( 8135909 )
1993
22
Immunohistochemical localization of metallothionein in human testicular embryonal carcinoma cells. ( 2508311 )
1989
23
Familial occurrence of testicular neoplasia: case report of testicular embryonal carcinoma in 2 brothers and a first cousin. ( 3735547 )
1986
24
Metastatic testicular embryonal carcinoma in a horse. ( 3946061 )
1986
25
Unusual intracardiac metastasis of a testicular embryonal carcinoma. ( 2993178 )
1985
26
Leydig cell hyperplasia due to a testicular embryonal carcinoma producing human chorionic gonadotropin. ( 6204557 )
1984
27
Differentiation of human testicular embryonal carcinoma and teratocarcinoma grown in nude mice and soft-agar cultures. ( 6535649 )
1984
28
Spinal cord compression by metastatic testicular embryonal carcinoma. ( 6674356 )
1983
29
Immunohistochemistry of alpha-fetoprotein in testicular embryonal carcinoma. ( 6162645 )
1981
30
In vitro cultivation of human testicular embryonal carcinoma and establishment of a new cell line. ( 520758 )
1979
31
Histologically benign teratoid metastasis of testicular embryonal carcinoma: report of five cases. ( 4687350 )
1973
32
TESTICULAR EMBRYONAL CARCINOMA WITH ADULT TERATOMATOUS METASTASES. ( 14139625 )
1964
33
Testicular embryonal carcinoma with choriocarcinomatous foci in an adolescent boy. ( 13970619 )
1963
34
Steroid biosynthesis by testicular embryonal carcinoma tissue; a clinical, biochemical and pathological study. ( 13260093 )
1955

Variations for Embryonal Testis Carcinoma

Expression for Embryonal Testis Carcinoma

Search GEO for disease gene expression data for Embryonal Testis Carcinoma.

Pathways for Embryonal Testis Carcinoma

Pathways related to Embryonal Testis Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.75 AFP POU5F1

GO Terms for Embryonal Testis Carcinoma

Biological processes related to Embryonal Testis Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene silencing by miRNA GO:0060965 8.62 DND1 POU5F1

Molecular functions related to Embryonal Testis Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 miRNA binding GO:0035198 8.62 DND1 POU5F1

Sources for Embryonal Testis Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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