MCID: EMB006
MIFTS: 36

Embryonal Testis Carcinoma

Categories: Cancer diseases, Endocrine diseases, Fetal diseases, Reproductive diseases

Aliases & Classifications for Embryonal Testis Carcinoma

MalaCards integrated aliases for Embryonal Testis Carcinoma:

Name: Embryonal Testis Carcinoma 12 15
Testicular Embryonal Carcinoma 12 73
Embryonal Carcinoma of the Testis 12
Embryonal Carcinoma of Testis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5680
NCIt 50 C6341
UMLS 73 C0238448

Summaries for Embryonal Testis Carcinoma

Disease Ontology : 12 An embryonal carcinoma that is located in the testis.

MalaCards based summary : Embryonal Testis Carcinoma, also known as testicular embryonal carcinoma, is related to intratubular embryonal carcinoma and embryonal carcinoma. An important gene associated with Embryonal Testis Carcinoma is PICSAR (P38 Inhibited Cutaneous Squamous Cell Carcinoma Associated LincRNA), and among its related pathways/superpathways is Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include testis, bone and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Embryonal Testis Carcinoma

Graphical network of the top 20 diseases related to Embryonal Testis Carcinoma:



Diseases related to Embryonal Testis Carcinoma

Symptoms & Phenotypes for Embryonal Testis Carcinoma

GenomeRNAi Phenotypes related to Embryonal Testis Carcinoma according to GeneCards Suite gene sharing:

26 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 10 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10 AFP PPP1R3A DDX6
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10 RNF168
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10 POU5F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10 POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10 PPP1R3A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10 PPP1R3A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10 RNF168
10 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10 RNF168
11 Increased shRNA abundance (Z-score > 2) GR00366-A-192 10 AFP POU5F1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10 RNF168
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10 AFP
14 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10 POU5F1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-44 10 DDX6
16 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10 RNF168
17 Increased shRNA abundance (Z-score > 2) GR00366-A-6 10 DDX6
18 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10 AFP PPP1R3A RNF168
19 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10 POU5F1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-76 10 RNF168
21 Increased shRNA abundance (Z-score > 2) GR00366-A-8 10 PPP1R3A
22 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10 PPP1R3A
23 Increased shRNA abundance (Z-score > 2) GR00366-A-82 10 PPP1R3A DDX6
24 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10 PPP1R3A

Drugs & Therapeutics for Embryonal Testis Carcinoma

Search Clinical Trials , NIH Clinical Center for Embryonal Testis Carcinoma

Genetic Tests for Embryonal Testis Carcinoma

Anatomical Context for Embryonal Testis Carcinoma

MalaCards organs/tissues related to Embryonal Testis Carcinoma:

41
Testis, Bone, Bone Marrow, Liver, Brain, Prostate, Myeloid

The Foundational Model of Anatomy Ontology organs/tissues related to Embryonal Testis Carcinoma:

19
The Testis

Publications for Embryonal Testis Carcinoma

Articles related to Embryonal Testis Carcinoma:

(show all 34)
# Title Authors Year
1
Imsnc761 and DDX6 synergistically suppress cell proliferation and promote apoptosis via p53 in testicular embryonal carcinoma cells. ( 29769412 )
2018
2
Hsa-miR-513b-5p suppresses cell proliferation and promotes P53 expression by targeting IRF2 in testicular embryonal carcinoma cells. ( 28512062 )
2017
3
Downregulation of miR-320a/383-sponge-like long non-coding RNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation. ( 26539909 )
2015
4
Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-I^/I'- and retinoic acid receptor-dependent mechanisms. ( 26431381 )
2015
5
Gonadotrophin-independent precocious puberty associated with later diagnosis of testicular embryonal carcinoma. ( 25012595 )
2014
6
microRNA-383 impairs phosphorylation of H2AX by targeting PNUTS and inducing cell cycle arrest in testicular embryonal carcinoma cells. ( 24462707 )
2014
7
Cisplatin induces resistance by triggering differentiation of testicular embryonal carcinoma cells. ( 24475288 )
2014
8
Testicular embryonal carcinoma: a morphologic study of 180 cases highlighting unusual and unemphasized aspects. ( 24503753 )
2014
9
MicroRNA-302a sensitizes testicular embryonal carcinoma cells to cisplatin-induced cell death. ( 23625774 )
2013
10
Transcription factors Sp1 and p73 control the expression of the proapoptotic protein NOXA in the response of testicular embryonal carcinoma cells to cisplatin. ( 22718761 )
2012
11
Mono-(2-ethylhexyl) phthalate (MEHP) promotes invasion and migration of human testicular embryonal carcinoma cells. ( 22321834 )
2012
12
Minimum regions of genomic imbalance in stage I testicular embryonal carcinoma and association of 22q loss with relapse. ( 21213372 )
2011
13
Downregulation of microRNA-383 is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation by targeting IRF1. ( 21368870 )
2010
14
Non-palpable testicular embryonal carcinoma diagnosed by ultrasound: a case report. ( 19066212 )
2009
15
Testicular embryonal carcinoma presenting as chest wall subcutaneous mass. ( 21938149 )
2009
16
Spontaneous regression of pulmonary metastases from testicular embryonal carcinoma. ( 18304227 )
2008
17
Four pregnancies and two deliveries after unilateral orchidectomy and chemotherapy for testicular embryonal carcinoma. ( 16211371 )
2005
18
Testicular embryonal carcinoma metastatic to the labial mucosa of the upper lip. ( 11337274 )
2001
19
Down's syndrome associated with intracranial germinoma and testicular embryonal carcinoma. ( 8533196 )
1995
20
MR findings of pineal yolk sac tumor in a patient with testicular embryonal carcinoma. ( 7922842 )
1994
21
Metastatic mature teratoma in lung following testicular embryonal carcinoma and teratocarcinoma. ( 8135909 )
1993
22
Immunohistochemical localization of metallothionein in human testicular embryonal carcinoma cells. ( 2508311 )
1989
23
Familial occurrence of testicular neoplasia: case report of testicular embryonal carcinoma in 2 brothers and a first cousin. ( 3735547 )
1986
24
Metastatic testicular embryonal carcinoma in a horse. ( 3946061 )
1986
25
Unusual intracardiac metastasis of a testicular embryonal carcinoma. ( 2993178 )
1985
26
Differentiation of human testicular embryonal carcinoma and teratocarcinoma grown in nude mice and soft-agar cultures. ( 6535649 )
1984
27
Leydig cell hyperplasia due to a testicular embryonal carcinoma producing human chorionic gonadotropin. ( 6204557 )
1984
28
Spinal cord compression by metastatic testicular embryonal carcinoma. ( 6674356 )
1983
29
Immunohistochemistry of alpha-fetoprotein in testicular embryonal carcinoma. ( 6162645 )
1981
30
In vitro cultivation of human testicular embryonal carcinoma and establishment of a new cell line. ( 520758 )
1979
31
Histologically benign teratoid metastasis of testicular embryonal carcinoma: report of five cases. ( 4687350 )
1973
32
TESTICULAR EMBRYONAL CARCINOMA WITH ADULT TERATOMATOUS METASTASES. ( 14139625 )
1964
33
Testicular embryonal carcinoma with choriocarcinomatous foci in an adolescent boy. ( 13970619 )
1963
34
Steroid biosynthesis by testicular embryonal carcinoma tissue; a clinical, biochemical and pathological study. ( 13260093 )
1955

Variations for Embryonal Testis Carcinoma

Expression for Embryonal Testis Carcinoma

Search GEO for disease gene expression data for Embryonal Testis Carcinoma.

Pathways for Embryonal Testis Carcinoma

Pathways related to Embryonal Testis Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.75 AFP POU5F1

GO Terms for Embryonal Testis Carcinoma

Biological processes related to Embryonal Testis Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene silencing by miRNA GO:0060965 8.62 DND1 POU5F1

Molecular functions related to Embryonal Testis Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 miRNA binding GO:0035198 8.62 DND1 POU5F1

Sources for Embryonal Testis Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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