ETMR
MCID: EMB015
MIFTS: 28

Embryonal Tumor with Multilayered Rosettes (ETMR)

Categories: Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Embryonal Tumor with Multilayered Rosettes

MalaCards integrated aliases for Embryonal Tumor with Multilayered Rosettes:

Name: Embryonal Tumor with Multilayered Rosettes 54
Ependymoblastoma 54 74
Embryonal Tumor with Abundant Neuropil and True Rosettes 54
Neuroectodermal Tumors Primitive 54
Etantr 54
Etmr 54

Classifications:



External Ids:

UMLS 74 C0700367

Summaries for Embryonal Tumor with Multilayered Rosettes

MalaCards based summary : Embryonal Tumor with Multilayered Rosettes, also known as ependymoblastoma, is related to pediatric infratentorial ependymoblastoma and adult ependymoblastoma, and has symptoms including vomiting and headache. An important gene associated with Embryonal Tumor with Multilayered Rosettes is LIN28A (Lin-28 Homolog A). The drugs Ondansetron and Granisetron have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and bone.

Related Diseases for Embryonal Tumor with Multilayered Rosettes

Diseases related to Embryonal Tumor with Multilayered Rosettes via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 pediatric infratentorial ependymoblastoma 12.1
2 adult ependymoblastoma 12.1
3 pediatric cerebral ependymoblastoma 12.1
4 ewing sarcoma 11.5
5 pediatric supratentorial ependymoma 11.1
6 medulloblastoma 10.3
7 ependymoma 10.3
8 atypical teratoid rhabdoid tumor 10.2
9 rhabdoid cancer 10.2
10 medulloepithelioma 10.2
11 ependymoblastoma 10.2
12 neuroblastoma 10.0
13 spinal cord ependymoma 10.0
14 anaplastic ependymoma 10.0
15 ewing's family of tumors 10.0
16 sarcoma 10.0

Graphical network of the top 20 diseases related to Embryonal Tumor with Multilayered Rosettes:



Diseases related to Embryonal Tumor with Multilayered Rosettes

Symptoms & Phenotypes for Embryonal Tumor with Multilayered Rosettes

UMLS symptoms related to Embryonal Tumor with Multilayered Rosettes:


vomiting, headache

Drugs & Therapeutics for Embryonal Tumor with Multilayered Rosettes

Drugs for Embryonal Tumor with Multilayered Rosettes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 188)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ondansetron Approved Phase 3 99614-02-5 4595
2
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
3
Cisplatin Approved Phase 3,Phase 2 15663-27-1 441203 84093 2767
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 1177-87-3
5
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
6
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
7
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
8
Histamine Approved, Investigational Phase 3 51-45-6 774
9
Cyproheptadine Approved Phase 3 129-03-3 2913
10
Dopamine Approved Phase 3 62-31-7, 51-61-6 681
11
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
12 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
13 Dermatologic Agents Phase 3,Phase 2,Phase 1
14 Emetics Phase 3
15 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
16 Autonomic Agents Phase 3,Phase 1
17 BB 1101 Phase 3,Phase 2,Phase 1
18 Antiemetics Phase 3,Phase 1
19 Gastrointestinal Agents Phase 3,Phase 1,Not Applicable
20 Anesthetics, General Phase 3
21 Adjuvants, Anesthesia Phase 3
22 Analgesics Phase 3,Phase 2,Phase 1
23 Liver Extracts Phase 3,Phase 1,Phase 2
24 Anesthetics Phase 3
25 Anesthetics, Intravenous Phase 3
26 Narcotics Phase 3
27 Analgesics, Opioid Phase 3
28 Central Nervous System Depressants Phase 3,Phase 2
29 Cola Phase 3,Phase 1
30 Neurotransmitter Agents Phase 3,Phase 2
31 Cholinergic Agents Phase 3,Phase 2
32 Nootropic Agents Phase 3,Phase 2
33 Cholinesterase Inhibitors Phase 3,Phase 2
34 Histamine Antagonists Phase 3
35 Antipruritics Phase 3
36 Serotonin Agents Phase 3
37 Serotonin Antagonists Phase 3
38 Histamine H1 Antagonists Phase 3
39
Histamine Phosphate Phase 3 51-74-1 65513
40 Anti-Allergic Agents Phase 3
41 Dexmethylphenidate Hydrochloride Phase 3
42 Neurotransmitter Uptake Inhibitors Phase 3
43 Dopamine Agents Phase 3
44 Dopamine Uptake Inhibitors Phase 3
45 Central Nervous System Stimulants Phase 3
46
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
47
Temozolomide Approved, Investigational Phase 1, Phase 2 85622-93-1 5394
48
Bevacizumab Approved, Investigational Phase 2 216974-75-3
49
Pregabalin Approved, Illicit, Investigational Phase 2 148553-50-8 5486971
50
Levetiracetam Approved, Investigational Phase 2 102767-28-2 441341

Interventional clinical trials:

(show top 50) (show all 55)
# Name Status NCT ID Phase Drugs
1 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
4 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
5 Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors Terminated NCT00031798 Phase 3 methylphenidate hydrochloride
6 Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma Completed NCT01977677 Phase 1, Phase 2 temozolomide;plerixafor
7 Bevacizumab and Lapatinib in Children With Recurrent or Refractory Ependymoma Completed NCT00883688 Phase 2 Bevacizumab;Lapatinib
8 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2 levetiracetam;pregabalin
9 Chemotherapy and Vaccine Therapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Recurrent or Refractory Brain Cancer Completed NCT00014573 Phase 2 carmustine;cisplatin;cyclophosphamide;paclitaxel
10 Combination Chemotherapy Followed by Radiation Therapy in Treating Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma Completed NCT00006258 Phase 2 cisplatin;cyclophosphamide;etoposide;methotrexate;vincristine sulfate
11 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
12 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Cancers Completed NCT00002752 Phase 1, Phase 2
13 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary Brain Tumors Completed NCT00003478 Phase 1, Phase 2
14 Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain Tumors Recruiting NCT02684071 Phase 2 Intra thecal methotrexate;topotecan;cyclophosphamide
15 Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors Recruiting NCT02095132 Phase 1, Phase 2 Adavosertib;Irinotecan Hydrochloride
16 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
17 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
18 Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Suspended NCT00983398 Phase 1, Phase 2 Carboplatin;Mannitol;Melphalan;Sodium Thiosulfate
19 Functional Magnetic Resonance Imaging and 1H-Nuclear Magnetic Resonance Spectroscopic Imaging in Treating Patients With Newly Diagnosed Brain Tumors Withdrawn NCT00005083 Phase 2
20 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
21 Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2 Completed NCT01082926 Phase 1
22 ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors Completed NCT00946335 Phase 1 veliparib;temozolomide
23 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
24 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
25 Cilengitide in Treating Children With Refractory Primary Brain Tumors Completed NCT00063973 Phase 1 cilengitide
26 Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors Completed NCT00052780 Phase 1 O6-benzylguanine;temozolomide
27 Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors Completed NCT00100880 Phase 1 lenalidomide
28 Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunction Completed NCT00030498 Phase 1 erlotinib hydrochloride
29 A Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors Completed NCT00784914 Phase 1 temsirolimus
30 Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment Completed NCT00544284 Phase 1 bortezomib;temozolomide
31 Monoclonal Antibody Therapy in Treating Patients With Recurrent Gliomas Completed NCT00002753 Phase 1
32 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
33 CC-5013 in Treating Patients With Recurrent Glioma Completed NCT00036894 Phase 1 lenalidomide
34 Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors Completed NCT00008086 Phase 1 carboplatin
35 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
36 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
37 Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas Completed NCT00019019 Phase 1 carboxyamidotriazole;paclitaxel
38 Carmustine in Treating Patients With Recurrent Malignant Glioma Completed NCT00004028 Phase 1 carmustine
39 Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer Completed NCT00003022 Phase 1
40 SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors Recruiting NCT03434262 Phase 1 Gemcitabine;ribociclib;sonidegib;trametinib
41 Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors Terminated NCT02255461 Phase 1 palbociclib isethionate
42 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
43 Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors Terminated NCT00110032 Phase 1 EF5
44 Gene Therapy and Chemotherapy in Treating Patients With Advanced Solid Tumors or Non-Hodgkin's Lymphoma Terminated NCT00003567 Phase 1 O6-benzylguanine;carmustine;temozolomide
45 Decision Making About Participating in Pharmacokinetic Studies in Patients Enrolled in a Phase I Treatment Clinical Trial Completed NCT00890435
46 Study of Blood and Cheek Cell Samples From Patients With Glioma Completed NCT01009307
47 Study of Tissue Samples From Patients With Glioma or Other Brain Tumors Completed NCT00967200
48 Changes in Semen or Sperm Caused by Temozolomide in Patients With Newly Diagnosed, Progressive, or Recurrent Primary Malignant Brain Tumors Completed NCT00499798
49 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671
50 Magnetic Resonance Imaging in Determining Extent of Cancer in Patients With Newly Diagnosed Glioma Completed NCT00005082 Not Applicable

Search NIH Clinical Center for Embryonal Tumor with Multilayered Rosettes

Genetic Tests for Embryonal Tumor with Multilayered Rosettes

Anatomical Context for Embryonal Tumor with Multilayered Rosettes

MalaCards organs/tissues related to Embryonal Tumor with Multilayered Rosettes:

42
Brain, Liver, Bone, T Cells, Kidney, Spinal Cord, Bone Marrow

Publications for Embryonal Tumor with Multilayered Rosettes

Articles related to Embryonal Tumor with Multilayered Rosettes:

(show all 20)
# Title Authors Year
1
Targeted radioimmunotherapy for embryonal tumor with multilayered rosettes. ( 30879172 )
2019
2
Four Levels of Diagnosis in the Rare Pediatric Embryonal Tumor of the CNS Called Embryonal Tumor with Multilayered Rosettes. ( 29528833 )
2018
3
Embryonal Tumor with Multilayered Rosettes Presenting with Intermittent Third Nerve Palsy. ( 29880079 )
2018
4
Embryonal tumor with multilayered rosettes: Diagnosis on intra-operative squash smear. ( 29514411 )
2018
5
Embryonal Tumor with Multilayered Rosettes, C19MC-Altered: Clinical, Pathological, and Neuroimaging Findings. ( 29797626 )
2018
6
Embryonal tumor with multilayered rosettes: illustrative case and review of the literature. ( 30215121 )
2018
7
Embryonal tumor with multilayered rosettes, C19MC-altered: Report of an extremely rare malignant pediatric central nervous system neoplasm. ( 29230288 )
2017
8
Embryonal Tumor with Multilayered Rosettes in a 3-Year-Old Girl: Case Report. ( 28191622 )
2017
9
LIN28A, a sensitive immunohistochemical marker for Embryonal Tumor with Multilayered Rosettes (ETMR), is also positive in a subset of Atypical Teratoid/Rhabdoid Tumor (AT/RT). ( 28744687 )
2017
10
Extracranial extra-CNS spread of embryonal tumor with multilayered rosettes (ETMR): case series and systematic review. ( 29177676 )
2017
11
Embryonal tumor with multilayered rosettes of the fourth ventricle: case report. ( 26252622 )
2015
12
Embryonal tumor with multilayered rosettes: diagnostic tools update and review of the literature. ( 23863344 )
2014
13
Congenital cerebellar embryonal tumor with multilayered rosettes: report of a rare case. ( 25308038 )
2014
14
A novel C19MC amplified cell line links Lin28/let-7 to mTOR signaling in embryonal tumor with multilayered rosettes. ( 24311633 )
2014
15
Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity. ( 24337497 )
2013
16
[Are the medulloepithelioma, ependymoblastoma and embryonal tumor with multilayered rosettes the same entity?]. ( 24558755 )
2013
17
Embryonal tumor with multilayered rosettes: Two case reports with a review of the literature. ( 22406791 )
2012
18
LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR). ( 23161096 )
2012
19
Embryonal tumor with abundant neuropil and true rosettes: morphological, immunohistochemical, ultrastructural and molecular study of a case showing features of medulloepithelioma and areas of mesenchymal and epithelial differentiation. ( 19563506 )
2010
20
Embryonal tumor with multilayered rosettes (ETMR): signed, sealed, delivered a8 ( 25012402 )
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Variations for Embryonal Tumor with Multilayered Rosettes

Expression for Embryonal Tumor with Multilayered Rosettes

Search GEO for disease gene expression data for Embryonal Tumor with Multilayered Rosettes.

Pathways for Embryonal Tumor with Multilayered Rosettes

GO Terms for Embryonal Tumor with Multilayered Rosettes

Sources for Embryonal Tumor with Multilayered Rosettes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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