MCID: EMB015
MIFTS: 29

Embryonal Tumor with Multilayered Rosettes

Categories: Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Embryonal Tumor with Multilayered Rosettes

MalaCards integrated aliases for Embryonal Tumor with Multilayered Rosettes:

Name: Embryonal Tumor with Multilayered Rosettes 54
Ependymoblastoma 54 74
Embryonal Tumor with Abundant Neuropil and True Rosettes 54
Neuroectodermal Tumors Primitive 54
Etantr 54
Etmr 54

Classifications:



External Ids:

UMLS 74 C0700367

Summaries for Embryonal Tumor with Multilayered Rosettes

MalaCards based summary : Embryonal Tumor with Multilayered Rosettes, also known as ependymoblastoma, is related to pediatric infratentorial ependymoblastoma and adult ependymoblastoma, and has symptoms including vomiting and headache. An important gene associated with Embryonal Tumor with Multilayered Rosettes is LIN28A (Lin-28 Homolog A). The drugs Ondansetron and Granisetron have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and liver.

Related Diseases for Embryonal Tumor with Multilayered Rosettes

Diseases related to Embryonal Tumor with Multilayered Rosettes via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 pediatric infratentorial ependymoblastoma 12.1
2 adult ependymoblastoma 12.1
3 pediatric cerebral ependymoblastoma 12.1
4 ewing sarcoma 11.5
5 pediatric supratentorial ependymoma 11.1
6 medulloblastoma 10.3
7 ependymoma 10.3
8 benign ependymoma 10.2
9 atypical teratoid rhabdoid tumor 10.2
10 rhabdoid cancer 10.2
11 medulloepithelioma 10.2
12 ependymoblastoma 10.2
13 spinal cord ependymoma 10.0
14 anaplastic ependymoma 10.0
15 ewing's family of tumors 10.0
16 heparin-induced thrombocytopenia 10.0
17 sarcoma 10.0

Graphical network of the top 20 diseases related to Embryonal Tumor with Multilayered Rosettes:



Diseases related to Embryonal Tumor with Multilayered Rosettes

Symptoms & Phenotypes for Embryonal Tumor with Multilayered Rosettes

UMLS symptoms related to Embryonal Tumor with Multilayered Rosettes:


vomiting, headache

Drugs & Therapeutics for Embryonal Tumor with Multilayered Rosettes

Drugs for Embryonal Tumor with Multilayered Rosettes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 188)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ondansetron Approved Phase 3 99614-02-5 4595
2
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
3
Cisplatin Approved Phase 3,Phase 2 15663-27-1 2767 441203 84093
4
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
5
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 1177-87-3
6
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
7
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
8
Histamine Approved, Investigational Phase 3 51-45-6 774
9
Cyproheptadine Approved Phase 3 129-03-3 2913
10
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
11
Dopamine Approved Phase 3 62-31-7, 51-61-6 681
12 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
13 Dermatologic Agents Phase 3,Phase 2,Phase 1
14 Gastrointestinal Agents Phase 3,Phase 1,Not Applicable
15 Antiemetics Phase 3,Phase 1
16 Emetics Phase 3
17 BB 1101 Phase 3,Phase 2,Phase 1
18 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
19 Autonomic Agents Phase 3,Phase 1
20 Narcotics Phase 3
21 Adjuvants, Anesthesia Phase 3
22 Analgesics Phase 3,Phase 2,Phase 1
23 Anesthetics, Intravenous Phase 3
24 Liver Extracts Phase 3,Phase 1,Phase 2
25 Anesthetics, General Phase 3
26 Anesthetics Phase 3
27 Analgesics, Opioid Phase 3
28 Central Nervous System Depressants Phase 3,Phase 2
29 Cola Phase 3,Phase 1
30 Cholinesterase Inhibitors Phase 3,Phase 2
31 Neurotransmitter Agents Phase 3,Phase 2
32 Nootropic Agents Phase 3,Phase 2
33 Cholinergic Agents Phase 3,Phase 2
34 Histamine Antagonists Phase 3
35 Serotonin Agents Phase 3
36 Serotonin Antagonists Phase 3
37 Anti-Allergic Agents Phase 3
38 Antipruritics Phase 3
39 Histamine H1 Antagonists Phase 3
40
Histamine Phosphate Phase 3 51-74-1 65513
41 Dexmethylphenidate Hydrochloride Phase 3
42 Dopamine Agents Phase 3
43 Central Nervous System Stimulants Phase 3
44 Dopamine Uptake Inhibitors Phase 3
45 Neurotransmitter Uptake Inhibitors Phase 3
46
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
47
Temozolomide Approved, Investigational Phase 1, Phase 2 85622-93-1 5394
48
Bevacizumab Approved, Investigational Phase 2 216974-75-3
49
Pregabalin Approved, Illicit, Investigational Phase 2 148553-50-8 5486971
50
Levetiracetam Approved, Investigational Phase 2 102767-28-2 441341

Interventional clinical trials:

(show top 50) (show all 55)
# Name Status NCT ID Phase Drugs
1 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
4 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
5 Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors Terminated NCT00031798 Phase 3 methylphenidate hydrochloride
6 Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma Completed NCT01977677 Phase 1, Phase 2 temozolomide;plerixafor
7 Bevacizumab and Lapatinib in Children With Recurrent or Refractory Ependymoma Completed NCT00883688 Phase 2 Bevacizumab;Lapatinib
8 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2 levetiracetam;pregabalin
9 Chemotherapy and Vaccine Therapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Recurrent or Refractory Brain Cancer Completed NCT00014573 Phase 2 carmustine;cisplatin;cyclophosphamide;paclitaxel
10 Combination Chemotherapy Followed by Radiation Therapy in Treating Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma Completed NCT00006258 Phase 2 cisplatin;cyclophosphamide;etoposide;methotrexate;vincristine sulfate
11 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
12 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Cancers Completed NCT00002752 Phase 1, Phase 2
13 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary Brain Tumors Completed NCT00003478 Phase 1, Phase 2
14 Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain Tumors Recruiting NCT02684071 Phase 2 Intra thecal methotrexate;topotecan;cyclophosphamide
15 Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors Recruiting NCT02095132 Phase 1, Phase 2 Adavosertib;Irinotecan Hydrochloride
16 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
17 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
18 Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Suspended NCT00983398 Phase 1, Phase 2 Carboplatin;Mannitol;Melphalan;Sodium Thiosulfate
19 Functional Magnetic Resonance Imaging and 1H-Nuclear Magnetic Resonance Spectroscopic Imaging in Treating Patients With Newly Diagnosed Brain Tumors Withdrawn NCT00005083 Phase 2
20 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
21 Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2 Completed NCT01082926 Phase 1
22 ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors Completed NCT00946335 Phase 1 veliparib;temozolomide
23 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
24 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
25 Cilengitide in Treating Children With Refractory Primary Brain Tumors Completed NCT00063973 Phase 1 cilengitide
26 Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors Completed NCT00052780 Phase 1 O6-benzylguanine;temozolomide
27 Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors Completed NCT00100880 Phase 1 lenalidomide
28 Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunction Completed NCT00030498 Phase 1 erlotinib hydrochloride
29 A Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors Completed NCT00784914 Phase 1 temsirolimus
30 Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment Completed NCT00544284 Phase 1 bortezomib;temozolomide
31 Monoclonal Antibody Therapy in Treating Patients With Recurrent Gliomas Completed NCT00002753 Phase 1
32 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
33 CC-5013 in Treating Patients With Recurrent Glioma Completed NCT00036894 Phase 1 lenalidomide
34 Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors Completed NCT00008086 Phase 1 carboplatin
35 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
36 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
37 Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas Completed NCT00019019 Phase 1 carboxyamidotriazole;paclitaxel
38 Carmustine in Treating Patients With Recurrent Malignant Glioma Completed NCT00004028 Phase 1 carmustine
39 Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer Completed NCT00003022 Phase 1
40 SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors Recruiting NCT03434262 Phase 1 Gemcitabine;ribociclib;sonidegib;trametinib
41 Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors Terminated NCT02255461 Phase 1 palbociclib isethionate
42 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
43 Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors Terminated NCT00110032 Phase 1 EF5
44 Gene Therapy and Chemotherapy in Treating Patients With Advanced Solid Tumors or Non-Hodgkin's Lymphoma Terminated NCT00003567 Phase 1 O6-benzylguanine;carmustine;temozolomide
45 Decision Making About Participating in Pharmacokinetic Studies in Patients Enrolled in a Phase I Treatment Clinical Trial Completed NCT00890435
46 Study of Blood and Cheek Cell Samples From Patients With Glioma Completed NCT01009307
47 Study of Tissue Samples From Patients With Glioma or Other Brain Tumors Completed NCT00967200
48 Changes in Semen or Sperm Caused by Temozolomide in Patients With Newly Diagnosed, Progressive, or Recurrent Primary Malignant Brain Tumors Completed NCT00499798
49 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671
50 Magnetic Resonance Imaging in Determining Extent of Cancer in Patients With Newly Diagnosed Glioma Completed NCT00005082 Not Applicable

Search NIH Clinical Center for Embryonal Tumor with Multilayered Rosettes

Genetic Tests for Embryonal Tumor with Multilayered Rosettes

Anatomical Context for Embryonal Tumor with Multilayered Rosettes

MalaCards organs/tissues related to Embryonal Tumor with Multilayered Rosettes:

42
Brain, Bone, Liver, T Cells, Spinal Cord, Kidney, Bone Marrow

Publications for Embryonal Tumor with Multilayered Rosettes

Articles related to Embryonal Tumor with Multilayered Rosettes:

(show top 50) (show all 80)
# Title Authors Year
1
Targeted radioimmunotherapy for embryonal tumor with multilayered rosettes. ( 30879172 )
2019
2
Integration of a Personalized Molecular Targeted Therapy into the Multimodal Treatment of Refractory Childhood Embryonal Tumor with Multilayered Rosettes (ETMR). ( 31011318 )
2019
3
A Congenital Case of Ependymoblastoma: A Rare and Aggressive Brain Tumor. ( 29432310 )
2019
4
Extracranial extra-CNS spread of embryonal tumor with multilayered rosettes (ETMR): case series and systematic review. ( 29177676 )
2018
5
Embryonal tumor with multilayered rosettes: Diagnosis on intra-operative squash smear. ( 29514411 )
2018
6
Four Levels of Diagnosis in the Rare Pediatric Embryonal Tumor of the CNS Called Embryonal Tumor with Multilayered Rosettes. ( 29528833 )
2018
7
Embryonal Tumor with Multilayered Rosettes, C19MC-Altered: Clinical, Pathological, and Neuroimaging Findings. ( 29797626 )
2018
8
Embryonal Tumor with Multilayered Rosettes Presenting with Intermittent Third Nerve Palsy. ( 29880079 )
2018
9
Embryonal tumor with multilayered rosettes: illustrative case and review of the literature. ( 30215121 )
2018
10
LIN28A, a sensitive immunohistochemical marker for Embryonal Tumor with Multilayered Rosettes (ETMR), is also positive in a subset of Atypical Teratoid/Rhabdoid Tumor (AT/RT). ( 28744687 )
2017
11
Embryonal Tumor with Multilayered Rosettes in a 3-Year-Old Girl: Case Report. ( 28191622 )
2017
12
Embryonal tumor with multilayered rosettes, C19MC-altered: Report of an extremely rare malignant pediatric central nervous system neoplasm. ( 29230288 )
2017
13
Lymph node metastasis of presacral ependymoblastoma in a young child. ( 28215462 )
2017
14
Embryonal tumor with multilayered rosettes of the fourth ventricle: case report. ( 26252622 )
2015
15
Systematic comparison of MRI findings in pediatric ependymoblastoma with ependymoma and CNS primitive neuroectodermal tumor not otherwise specified. ( 25916887 )
2015
16
Posterior fossa ependymoblastoma diagnosed in the second month of life: uneventful 12 years survival after gross total resection followed by chemotherapy. ( 26251773 )
2015
17
Sacrococcygeal ependymoblastoma. ( 26493054 )
2015
18
Embryonal tumor with multilayered rosettes: diagnostic tools update and review of the literature. ( 23863344 )
2014
19
A novel C19MC amplified cell line links Lin28/let-7 to mTOR signaling in embryonal tumor with multilayered rosettes. ( 24311633 )
2014
20
Embryonal tumor with multilayered rosettes (ETMR): signed, sealed, delivered …. ( 25012402 )
2014
21
Congenital cerebellar embryonal tumor with multilayered rosettes: report of a rare case. ( 25308038 )
2014
22
MRI characteristics of ependymoblastoma: results from 22 centrally reviewed cases. ( 24948504 )
2014
23
MET T992I mutation in a case of ependymoblastoma/embryonal tumour with multilayered rosettes. ( 25194039 )
2014
24
Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity. ( 24337497 )
2014
25
Ependymoblastoma of the brainstem: MRI findings and differential diagnosis. ( 24464920 )
2014
26
A case report of an ependymoblastoma in the rectovaginal space and a review of the literature. ( 24511018 )
2014
27
Ependymoblastoma with cystic change in a child. ( 24724717 )
2014
28
[Are the medulloepithelioma, ependymoblastoma and embryonal tumor with multilayered rosettes the same entity?]. ( 24558755 )
2013
29
Embryonal tumor with multilayered rosettes: Two case reports with a review of the literature. ( 22406791 )
2012
30
LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR). ( 23161096 )
2012
31
Outcome of 11 children with ependymoblastoma treated within the prospective HIT-trials between 1991 and 2006. ( 21308398 )
2011
32
Ependymoblastoma in an adult: a diagnostic challenge on cytology. ( 22674109 )
2011
33
Ependymoblastoma: dear, damned, distracting diagnosis, farewell!*. ( 19120373 )
2010
34
Embryonal tumor with abundant neuropil and true rosettes: morphological, immunohistochemical, ultrastructural and molecular study of a case showing features of medulloepithelioma and areas of mesenchymal and epithelial differentiation. ( 19563506 )
2010
35
Ependymoblastoma in a Japanese Black heifer. ( 19887749 )
2009
36
Divergent ependymal tumor (ependymoblastoma/anaplastic ependymoma) of the posterior fossa: an uncommon case observed in a child. ( 18827270 )
2008
37
Congenital ependymoblastoma arising in the sacrococcygeal soft tissue: a case study. ( 18402386 )
2008
38
Tumor suppressor proteins are differentially affected in human ependymoblastoma and medulloblastoma cells exposed to nerve growth factor. ( 17453820 )
2007
39
In vitro human ependymoblastoma cells differentiate after exposure to nerve growth factor. ( 15906158 )
2004
40
Ependymoblastoma: MR presentation. A case report and review of the literature. ( 7491192 )
1995
41
Ependymoblastoma: a clinical review. ( 8570066 )
1995
42
Ependymoblastoma in an HIV-positive hemophilic girl. ( 8084312 )
1994
43
Tentorial traversal by ependymoblastoma. ( 1899507 )
1991
44
Limits of tumour treatment follow up by surface coil 31P magnetic resonance spectroscopy. The case of sarcosinamide-CNU treated ependymoblastoma. ( 2484278 )
1989
45
Ependymoblastoma: a histological, immunohistological and ultrastructural study of five cases. ( 3286469 )
1988
46
Congenital ependymoblastoma presenting as a sacrococcygeal mass in a newborn: an immunohistochemical, light and electron microscopic study. ( 3308267 )
1987
47
The expression and detection of MHC class I antigens on murine neuroblastoma and ependymoblastoma lines. ( 3492512 )
1987
48
Primary leptomeningeal ependymoblastoma. Case report. ( 3701447 )
1986
49
The ultrastructure of the ependymoblastoma. ( 3776467 )
1986
50
Primary intracranial ependymoblastoma presenting as spinal cord compression due to metastasis. ( 3829033 )
1986

Variations for Embryonal Tumor with Multilayered Rosettes

Expression for Embryonal Tumor with Multilayered Rosettes

Search GEO for disease gene expression data for Embryonal Tumor with Multilayered Rosettes.

Pathways for Embryonal Tumor with Multilayered Rosettes

GO Terms for Embryonal Tumor with Multilayered Rosettes

Sources for Embryonal Tumor with Multilayered Rosettes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....