MCID: EMB015
MIFTS: 27

Embryonal Tumor with Multilayered Rosettes

Categories: Rare diseases, Neuronal diseases, Fetal diseases

Aliases & Classifications for Embryonal Tumor with Multilayered Rosettes

MalaCards integrated aliases for Embryonal Tumor with Multilayered Rosettes:

Name: Embryonal Tumor with Multilayered Rosettes 53
Ependymoblastoma 53 73
Embryonal Tumor with Abundant Neuropil and True Rosettes 53
Neuroectodermal Tumors Primitive 53
Etantr 53
Etmr 53

Classifications:



Summaries for Embryonal Tumor with Multilayered Rosettes

MalaCards based summary : Embryonal Tumor with Multilayered Rosettes, also known as ependymoblastoma, is related to ewing's family of tumors and ewing sarcoma, and has symptoms including headache and vomiting. An important gene associated with Embryonal Tumor with Multilayered Rosettes is LIN28A (Lin-28 Homolog A). The drugs Cisplatin and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and bone.

Related Diseases for Embryonal Tumor with Multilayered Rosettes

Diseases related to Embryonal Tumor with Multilayered Rosettes via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 ewing's family of tumors 11.6
2 ewing sarcoma 11.3
3 medulloblastoma 11.2
4 medulloepithelioma 10.2
5 atypical teratoid rhabdoid tumor 10.1
6 rhabdoid cancer 10.1
7 ependymoblastoma 10.1
8 intraocular medulloepithelioma 10.1

Graphical network of the top 20 diseases related to Embryonal Tumor with Multilayered Rosettes:



Diseases related to Embryonal Tumor with Multilayered Rosettes

Symptoms & Phenotypes for Embryonal Tumor with Multilayered Rosettes

UMLS symptoms related to Embryonal Tumor with Multilayered Rosettes:


headache, vomiting

Drugs & Therapeutics for Embryonal Tumor with Multilayered Rosettes

Drugs for Embryonal Tumor with Multilayered Rosettes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 177)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2 15663-27-1 84093 441203 2767
2
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
3
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
4
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
5
Ondansetron Approved Phase 3 99614-02-5 4595
6
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
7
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
8
Cyproheptadine Approved Phase 3 129-03-3 2913
9
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
10
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
11 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
12 Dermatologic Agents Phase 3,Phase 2,Phase 1
13 Dexamethasone acetate Phase 3,Phase 2,Phase 1 1177-87-3
14 Analgesics Phase 3,Phase 2,Phase 1
15 Central Nervous System Depressants Phase 3,Phase 2
16 Adjuvants, Anesthesia Phase 3
17 Cholinergic Agents Phase 3,Phase 2
18 Cholinesterase Inhibitors Phase 3,Phase 2
19 Gastrointestinal Agents Phase 3,Phase 1,Not Applicable
20 Narcotics Phase 3
21 Neurotransmitter Agents Phase 3,Phase 2
22 Analgesics, Opioid Phase 3
23 Anesthetics Phase 3
24 Nootropic Agents Phase 3,Phase 2
25 Anesthetics, General Phase 3
26 Anesthetics, Intravenous Phase 3
27 Emetics Phase 3
28 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
29 Antiemetics Phase 3,Phase 1
30 Liver Extracts Phase 3,Phase 1,Phase 2
31 BB 1101 Phase 3,Phase 2,Phase 1
32 Autonomic Agents Phase 3,Phase 1
33
Histamine Phosphate Phase 3 51-74-1 65513
34 Central Nervous System Stimulants Phase 3
35 Serotonin Agents Phase 3
36 Serotonin Antagonists Phase 3
37 Histamine Antagonists Phase 3
38 Histamine H1 Antagonists Phase 3
39 Neurotransmitter Uptake Inhibitors Phase 3
40 Dexmethylphenidate Hydrochloride Phase 3
41 Anti-Allergic Agents Phase 3
42 Dopamine Agents Phase 3
43 Dopamine Uptake Inhibitors Phase 3
44 Antipruritics Phase 3
45 Cola Nutraceutical Phase 3,Phase 1
46
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
47
Lenograstim Approved, Investigational Phase 2,Phase 1 135968-09-1
48
Etoposide Approved Phase 2,Phase 1 33419-42-0 36462
49
Carboplatin Approved Phase 1, Phase 2,Phase 2 41575-94-4 10339178 498142 38904
50
Dacarbazine Approved, Investigational Phase 1, Phase 2 4342-03-4 5351166

Interventional clinical trials:

(show top 50) (show all 55)
# Name Status NCT ID Phase Drugs
1 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
4 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
5 Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors Terminated NCT00031798 Phase 3 methylphenidate hydrochloride
6 Bevacizumab and Lapatinib in Children With Recurrent or Refractory Ependymoma Completed NCT00883688 Phase 2 Bevacizumab;Lapatinib
7 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2 levetiracetam;pregabalin
8 Chemotherapy and Vaccine Therapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Recurrent or Refractory Brain Cancer Completed NCT00014573 Phase 2 carmustine;cisplatin;cyclophosphamide;paclitaxel
9 Combination Chemotherapy Followed by Radiation Therapy in Treating Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma Completed NCT00006258 Phase 2 cisplatin;cyclophosphamide;etoposide;methotrexate;vincristine sulfate
10 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
11 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Cancers Completed NCT00002752 Phase 1, Phase 2
12 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary Brain Tumors Completed NCT00003478 Phase 1, Phase 2
13 Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain Tumors Recruiting NCT02684071 Phase 2 Intra thecal methotrexate;topotecan;cyclophosphamide
14 Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma Active, not recruiting NCT01977677 Phase 1, Phase 2 temozolomide;plerixafor
15 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2 crizotinib
16 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
17 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
18 Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Suspended NCT00983398 Phase 1, Phase 2 Carboplatin;Mannitol;Melphalan;Sodium Thiosulfate
19 Functional Magnetic Resonance Imaging and 1H-Nuclear Magnetic Resonance Spectroscopic Imaging in Treating Patients With Newly Diagnosed Brain Tumors Withdrawn NCT00005083 Phase 2
20 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
21 Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Gluco Completed NCT01082926 Phase 1
22 ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors Completed NCT00946335 Phase 1 veliparib;temozolomide
23 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
24 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
25 Cilengitide in Treating Children With Refractory Primary Brain Tumors Completed NCT00063973 Phase 1 cilengitide
26 Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors Completed NCT00052780 Phase 1 O6-benzylguanine;temozolomide
27 Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors Completed NCT00100880 Phase 1 lenalidomide
28 Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunction Completed NCT00030498 Phase 1 erlotinib hydrochloride
29 A Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors Completed NCT00784914 Phase 1 temsirolimus
30 Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment Completed NCT00544284 Phase 1 bortezomib;temozolomide
31 Monoclonal Antibody Therapy in Treating Patients With Recurrent Gliomas Completed NCT00002753 Phase 1
32 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
33 CC-5013 in Treating Patients With Recurrent Glioma Completed NCT00036894 Phase 1 lenalidomide
34 Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors Completed NCT00008086 Phase 1 carboplatin
35 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
36 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
37 Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas Completed NCT00019019 Phase 1 carboxyamidotriazole;paclitaxel
38 Carmustine in Treating Patients With Recurrent Malignant Glioma Completed NCT00004028 Phase 1 carmustine
39 Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer Completed NCT00003022 Phase 1
40 SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors Recruiting NCT03434262 Phase 1 Gemcitabine;ribociclib;sonidegib;trametinib
41 Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors Recruiting NCT02255461 Phase 1 palbociclib isethionate
42 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
43 Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors Terminated NCT00110032 Phase 1 EF5
44 Gene Therapy and Chemotherapy in Treating Patients With Advanced Solid Tumors or Non-Hodgkin's Lymphoma Terminated NCT00003567 Phase 1 O6-benzylguanine;carmustine;temozolomide
45 Decision Making About Participating in Pharmacokinetic Studies in Patients Enrolled in a Phase I Treatment Clinical Trial Completed NCT00890435
46 Study of Blood and Cheek Cell Samples From Patients With Glioma Completed NCT01009307
47 Study of Tissue Samples From Patients With Glioma or Other Brain Tumors Completed NCT00967200
48 Changes in Semen or Sperm Caused by Temozolomide in Patients With Newly Diagnosed, Progressive, or Recurrent Primary Malignant Brain Tumors Completed NCT00499798
49 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671
50 Magnetic Resonance Imaging in Determining Extent of Cancer in Patients With Newly Diagnosed Glioma Completed NCT00005082 Not Applicable

Search NIH Clinical Center for Embryonal Tumor with Multilayered Rosettes

Genetic Tests for Embryonal Tumor with Multilayered Rosettes

Anatomical Context for Embryonal Tumor with Multilayered Rosettes

MalaCards organs/tissues related to Embryonal Tumor with Multilayered Rosettes:

41
Brain, T Cells, Bone, Liver, Spinal Cord, Bone Marrow, Kidney

Publications for Embryonal Tumor with Multilayered Rosettes

Articles related to Embryonal Tumor with Multilayered Rosettes:

(show all 20)
# Title Authors Year
1
Four Levels of Diagnosis in the Rare Pediatric Embryonal Tumor of the CNS Called Embryonal Tumor with Multilayered Rosettes. ( 29528833 )
2018
2
Embryonal Tumor with Multilayered Rosettes Presenting with Intermittent Third Nerve Palsy. ( 29880079 )
2018
3
Embryonal tumor with multilayered rosettes: Diagnosis on intra-operative squash smear. ( 29514411 )
2018
4
Embryonal Tumor with Multilayered Rosettes, C19MC-Altered: Clinical, Pathological, and Neuroimaging Findings. ( 29797626 )
2018
5
Embryonal tumor with multilayered rosettes, C19MC-altered: Report of an extremely rare malignant pediatric central nervous system neoplasm. ( 29230288 )
2017
6
Embryonal Tumor with Multilayered Rosettes in a 3-Year-Old Girl: Case Report. ( 28191622 )
2017
7
LIN28A, a sensitive immunohistochemical marker for Embryonal Tumor with Multilayered Rosettes (ETMR), is also positive in a subset of Atypical Teratoid/Rhabdoid Tumor (AT/RT). ( 28744687 )
2017
8
Extracranial extra-CNS spread of embryonal tumor with multilayered rosettes (ETMR): case series and systematic review. ( 29177676 )
2017
9
Intraocular Medulloepitheliomas and Embryonal Tumors With Multilayered Rosettes of the Brain: Comparative Roles of LIN28A and C19MC. ( 25748578 )
2015
10
Embryonal tumor with multilayered rosettes of the fourth ventricle: case report. ( 26252622 )
2015
11
Embryonal tumor with multilayered rosettes: diagnostic tools update and review of the literature. ( 23863344 )
2014
12
Congenital cerebellar embryonal tumor with multilayered rosettes: report of a rare case. ( 25308038 )
2014
13
A novel C19MC amplified cell line links Lin28/let-7 to mTOR signaling in embryonal tumor with multilayered rosettes. ( 24311633 )
2014
14
Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity. ( 24337497 )
2013
15
[Are the medulloepithelioma, ependymoblastoma and embryonal tumor with multilayered rosettes the same entity?]. ( 24558755 )
2013
16
Embryonal tumor with multilayered rosettes: Two case reports with a review of the literature. ( 22406791 )
2012
17
LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR). ( 23161096 )
2012
18
Embryonal tumor with abundant neuropil and true rosettes: morphological, immunohistochemical, ultrastructural and molecular study of a case showing features of medulloepithelioma and areas of mesenchymal and epithelial differentiation. ( 19563506 )
2010
19
Embryonal tumors with abundant neuropil and true rosettes: a distinctive CNS primitive neuroectodermal tumor. ( 18987548 )
2009
20
Embryonal tumor with multilayered rosettes (ETMR): signed, sealed, delivered a8 ( 25012402 )
0

Variations for Embryonal Tumor with Multilayered Rosettes

Expression for Embryonal Tumor with Multilayered Rosettes

Search GEO for disease gene expression data for Embryonal Tumor with Multilayered Rosettes.

Pathways for Embryonal Tumor with Multilayered Rosettes

GO Terms for Embryonal Tumor with Multilayered Rosettes

Sources for Embryonal Tumor with Multilayered Rosettes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....