EDMD3
MCID: EMR020
MIFTS: 43

Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive (EDMD3)

Categories: Bone diseases, Cardiovascular diseases, Genetic diseases, Muscle diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive

MalaCards integrated aliases for Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive:

Name: Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive 57 12 72 29 6
Edmd3 57 12 58 72
Autosomal Recessive Emery-Dreifuss Muscular Dystrophy 3 12 15
Autosomal Recessive Emery-Dreifuss Muscular Dystrophy 58 70
Dystrophy, Muscular, Emery-Dreifuss, Type 3, Autosomal Recessive 39
Emery-Dreifuss Muscular Dystrophy Atypical Autosomal Recessive 72
Emery-Dreifuss Muscular Dystrophy 3 70

Characteristics:

Orphanet epidemiological data:

58
autosomal recessive emery-dreifuss muscular dystrophy
Inheritance: Autosomal recessive;

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal recessive

Miscellaneous:
progressive disorder
variable age at onset, usually first or second decade
heterozygous mutation carriers may have late-onset cardiac arrhythmias
three unrelated families have been reported (last curated august 2015)


HPO:

31
emery-dreifuss muscular dystrophy 3, autosomal recessive:
Inheritance autosomal recessive inheritance
Onset and clinical course progressive


Classifications:

Orphanet: 58  
Rare neurological diseases


Summaries for Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive

OMIM® : 57 Emery-Dreifuss muscular dystrophy is characterized classically by the triad of weakness of the shoulder and pelvic girdle muscles, contractures of the elbows, neck, and Achilles tendon, and cardiac involvement, most commonly arrhythmias (summary by Jimenez-Escrig et al., 2012). For a discussion of genetic heterogeneity of EDMD, see 310300. (616516) (Updated 05-Apr-2021)

MalaCards based summary : Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive, also known as edmd3, is related to mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome and familial partial lipodystrophy, and has symptoms including torticollis An important gene associated with Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive is LMNA (Lamin A/C), and among its related pathways/superpathways are Cell Cycle, Mitotic and Meiosis. Affiliated tissues include adipocyte, and related phenotypes are joint stiffness and myotonia

Disease Ontology : 12 An Emery-Dreifuss muscular dystrophy that has material basis in an autosomal recessive mutation of LMNA on chromosome 1q22.

UniProtKB/Swiss-Prot : 72 Emery-Dreifuss muscular dystrophy 3, autosomal recessive: A form of Emery-Dreifuss muscular dystrophy, a degenerative myopathy characterized by weakness and atrophy of muscle without involvement of the nervous system, early contractures of the elbows, Achilles tendons and spine, and cardiomyopathy associated with cardiac conduction defects.

Related Diseases for Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive

Diseases in the Emery-Dreifuss Muscular Dystrophy family:

Emery-Dreifuss Muscular Dystrophy 2, Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 4, Autosomal Dominant
Emery-Dreifuss Muscular Dystrophy 5, Autosomal Dominant Emery-Dreifuss Muscular Dystrophy 7, Autosomal Dominant
Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive

Diseases related to Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 30.3 ZMPSTE24 LMNA
2 familial partial lipodystrophy 30.3 LMNA EMD
3 lipodystrophy, familial partial, type 2 30.1 ZMPSTE24 LMNA
4 muscular dystrophy 29.5 TMEM43 SYNE2 SYNE1 SUN2 SUN1 LMNB2
5 laminopathy 29.1 ZMPSTE24 SYNE2 SUN2 SUN1 LMNB2 LMNA
6 emery-dreifuss muscular dystrophy 27.6 ZMPSTE24 TMEM43 SYNE4 SYNE3 SYNE2 SYNE1
7 emery-dreifuss muscular dystrophy 2, autosomal dominant 27.5 ZMPSTE24 TMEM43 SYNE4 SYNE3 SYNE2 SYNE1
8 charcot-marie-tooth disease, axonal, type 2e 10.5
9 limb-girdle muscular dystrophy 10.3
10 lmna-related dilated cardiomyopathy 10.3
11 limb-girdle muscular dystrophy type 1b 10.3
12 monogenic diabetes 10.3
13 familial isolated arrhythmogenic ventricular dysplasia, left dominant form 10.2 TMEM43 LMNA
14 familial isolated arrhythmogenic ventricular dysplasia, biventricular form 10.2 TMEM43 LMNA
15 familial isolated arrhythmogenic ventricular dysplasia, right dominant form 10.2 TMEM43 LMNA
16 left bundle branch hemiblock 10.2 TMEM43 LMNA
17 first-degree atrioventricular block 10.2 LMNA EMD
18 arrhythmogenic right ventricular dysplasia, familial, 5 10.2 TMEM43 EMD
19 arrhythmogenic right ventricular dysplasia, familial, 9 10.2 TMEM43 LMNA
20 autosomal dominant limb-girdle muscular dystrophy 10.1 LMNA EMD
21 nonencapsulated sclerosing carcinoma 10.1 LMNB2 LMNA
22 emerinopathy 10.0 SUN2 LMNA EMD
23 mandibuloacral dysplasia with type a lipodystrophy 10.0 ZMPSTE24 LMNA
24 atrial standstill 1 9.9 TMEM43 LMNA EMD
25 acroosteolysis 9.9 ZMPSTE24 LMNA
26 acquired generalized lipodystrophy 9.9 ZMPSTE24 LMNA
27 x-linked emery-dreifuss muscular dystrophy 9.9 SYNE2 SYNE1 LMNA EMD
28 complete generalized lipodystrophy 9.9 ZMPSTE24 LMNA
29 muscular disease 9.9 LMNB2 LMNA EMD
30 restrictive dermopathy, lethal 9.9 ZMPSTE24 LMNA
31 arrhythmogenic right ventricular cardiomyopathy 9.9 TMEM43 LMNA EMD
32 muscle tissue disease 9.9 LMNB2 LMNA EMD
33 cardiomyopathy, dilated, with hypergonadotropic hypogonadism 9.8 ZMPSTE24 SYNE2 LMNA
34 skin atrophy 9.8 ZMPSTE24 LMNA
35 osteopoikilosis 9.8 SYNE2 PLPP7 LMNA EMD
36 emery-dreifuss muscular dystrophy 4, autosomal dominant 9.8 TMEM43 SYNE2 SYNE1 LMNA EMD
37 charcot-marie-tooth disease 9.7 SUN2 LMNB2 LMNA EMD
38 neuromuscular disease 9.7 SUN2 LMNB2 LMNA EMD
39 congenital generalized lipodystrophy 9.6 ZMPSTE24 LMNB2 LMNA
40 buschke-ollendorff syndrome 9.6 SYNE2 SYNE1 LMNB2 LMNA EMD
41 myopathy 9.6 TMEM43 SYNE2 SYNE1 SUN2 LMNA EMD
42 dilated cardiomyopathy 9.5 TMEM43 SYNE2 SYNE1 SUN2 LMNA EMD
43 emery-dreifuss muscular dystrophy 7, autosomal dominant 9.5 TMEM43 SYNE2 SYNE1 SUN2 SUN1 EMD
44 lipodystrophy, familial partial, type 5 9.5 ZMPSTE24 LMNB2 LMNA EMD
45 reynolds syndrome 9.4 ZMPSTE24 SUN2 LMNB2 LMNA
46 pelger-huet anomaly 9.4 SYNE2 SYNE1 SUN1 LMNB2 LMNA EMD
47 emery-dreifuss muscular dystrophy 5, autosomal dominant 9.4 TMEM43 SYNE2 SYNE1 SUN2 SUN1 LMNA
48 leukodystrophy, demyelinating, adult-onset, autosomal dominant 9.3 ZMPSTE24 SYNE2 LMNB2 LMNA EMD
49 myopathy, x-linked, with postural muscle atrophy 9.3 TMEM43 SYNE2 SYNE1 SUN2 PLPP7 LMNA
50 greenberg dysplasia 9.2 SYNE2 SYNE1 SUN2 SUN1 LMNB2 LMNA

Graphical network of the top 20 diseases related to Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive:



Diseases related to Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive

Symptoms & Phenotypes for Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive

Human phenotypes related to Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive:

58 31 (show all 44)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 joint stiffness 58 31 hallmark (90%) Very frequent (99-80%) HP:0001387
2 myotonia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002486
3 pectus excavatum 58 31 hallmark (90%) Very frequent (99-80%) HP:0000767
4 elevated serum creatine kinase 58 31 hallmark (90%) Very frequent (99-80%) HP:0003236
5 limb-girdle muscular dystrophy 58 31 hallmark (90%) Very frequent (99-80%) HP:0006785
6 hyporeflexia of lower limbs 58 31 hallmark (90%) Very frequent (99-80%) HP:0002600
7 sudden cardiac death 58 31 frequent (33%) Frequent (79-30%) HP:0001645
8 hypertriglyceridemia 58 31 occasional (7.5%) Frequent (79-30%) HP:0002155
9 dilated cardiomyopathy 58 31 frequent (33%) Frequent (79-30%) HP:0001644
10 atrioventricular block 58 31 frequent (33%) Frequent (79-30%) HP:0001678
11 sprengel anomaly 58 31 frequent (33%) Frequent (79-30%) HP:0000912
12 achilles tendon contracture 58 31 frequent (33%) Frequent (79-30%) HP:0001771
13 waddling gait 58 31 frequent (33%) Frequent (79-30%) HP:0002515
14 elbow flexion contracture 58 31 frequent (33%) Frequent (79-30%) HP:0002987
15 increased ldl cholesterol concentration 58 31 occasional (7.5%) Frequent (79-30%) HP:0003141
16 spinal rigidity 58 31 frequent (33%) Frequent (79-30%) HP:0003306
17 back pain 58 31 frequent (33%) Frequent (79-30%) HP:0003418
18 emg: myopathic abnormalities 58 31 frequent (33%) Frequent (79-30%) HP:0003458
19 scapular winging 58 31 frequent (33%) Frequent (79-30%) HP:0003691
20 rimmed vacuoles 58 31 frequent (33%) Frequent (79-30%) HP:0003805
21 decreased cervical spine flexion due to contractures of posterior cervical muscles 58 31 frequent (33%) Frequent (79-30%) HP:0004631
22 proximal upper limb amyotrophy 58 31 frequent (33%) Frequent (79-30%) HP:0008948
23 proximal lower limb amyotrophy 58 31 frequent (33%) Frequent (79-30%) HP:0008956
24 proximal muscle weakness in lower limbs 58 31 frequent (33%) Frequent (79-30%) HP:0008994
25 proximal muscle weakness in upper limbs 58 31 frequent (33%) Frequent (79-30%) HP:0008997
26 type 1 muscle fiber atrophy 58 31 frequent (33%) Frequent (79-30%) HP:0011807
27 absent muscle fiber emerin 58 31 frequent (33%) Frequent (79-30%) HP:0030117
28 toe walking 58 31 frequent (33%) Frequent (79-30%) HP:0040083
29 supraventricular arrhythmia 58 31 frequent (33%) Frequent (79-30%) HP:0005115
30 ventricular escape rhythm 58 31 frequent (33%) Frequent (79-30%) HP:0005155
31 scoliosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002650
32 kyphosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002808
33 hyperlordosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0003307
34 ichthyosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0008064
35 obesity 58 31 occasional (7.5%) Occasional (29-5%) HP:0001513
36 lipodystrophy 58 31 occasional (7.5%) Occasional (29-5%) HP:0009125
37 hypotonia 31 occasional (7.5%) HP:0001252
38 gait disturbance 58 31 Frequent (79-30%) HP:0001288
39 intellectual disability 58 Excluded (0%)
40 muscular hypotonia 58 Occasional (29-5%)
41 muscle weakness 31 HP:0001324
42 myopathy 58 Very frequent (99-80%)
43 arrhythmia 31 HP:0011675
44 muscular dystrophy 31 HP:0003560

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Skeletal Spine:
scoliosis (in some patients)

Skeletal Limbs:
elbow contractures

Muscle Soft Tissue:
gait difficulties
muscle biopsy shows dystrophic changes
muscle weakness, proximal, upper and lower limbs
muscle atrophy, proximal, upper and lower limbs
partial lipodystrophy (abnormal distribution of subcutaneous adipose tissue) (1 family)

Skeletal Feet:
heel cord contractures

Laboratory Abnormalities:
increased serum creatine kinase
increased triglycerides (1 family)
increased ldl cholesterol (1 family)

Cardiovascular Heart:
arrhythmias
premature supraventricular and ventricular contractions

Head And Neck Neck:
neck contractures

Neurologic Peripheral Nervous System:
loss of reflexes in the lower limbs

Clinical features from OMIM®:

616516 (Updated 05-Apr-2021)

UMLS symptoms related to Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive:


torticollis

MGI Mouse Phenotypes related to Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 EMD LMNA PLPP7 SUN1 SYNE1 SYNE2
2 cellular MP:0005384 9.91 EMD LMNA LMNB2 PLPP7 SUN1 SUN2
3 mortality/aging MP:0010768 9.81 LMNA LMNB2 PLPP7 SUN1 SUN2 SYNE1
4 muscle MP:0005369 9.61 EMD LMNA LMNB2 PLPP7 SUN1 SUN2
5 nervous system MP:0003631 9.28 LMNA LMNB2 PLPP7 SUN1 SUN2 SYNE1

Drugs & Therapeutics for Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive

Search Clinical Trials , NIH Clinical Center for Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive

Genetic Tests for Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive

Genetic tests related to Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive:

# Genetic test Affiliating Genes
1 Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive 29 LMNA

Anatomical Context for Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive

MalaCards organs/tissues related to Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive:

40
Adipocyte

Publications for Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive

Articles related to Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive:

# Title Authors PMID Year
1
Homozygous lamin A/C familial lipodystrophy R482Q mutation in autosomal recessive Emery Dreifuss muscular dystrophy. 61 57 6
23313286 2013
2
Autosomal recessive Emery-Dreifuss muscular dystrophy caused by a novel mutation (R225Q) in the lamin A/C gene identified by exome sequencing. 6 61 57
22431096 2012
3
Different mutations in the LMNA gene cause autosomal dominant and autosomal recessive Emery-Dreifuss muscular dystrophy. 61 57 6
10739764 2000
4
Nuclear lamin A inhibits adipocyte differentiation: implications for Dunnigan-type familial partial lipodystrophy. 6
16415042 2006
5
Drawing the line in progeria syndromes. 6
12927424 2003
6
LMNA, encoding lamin A/C, is mutated in partial lipodystrophy. 6
10655060 2000
7
Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy. 6
10587585 2000
8
[Autosomal recessive Emery-Dreifuss muscular dystrophy(AR-EDMD)]. 61
11555962 2001

Variations for Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive

ClinVar genetic disease variations for Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 LMNA NM_170707.4(LMNA):c.664C>T (p.His222Tyr) SNV Pathogenic 14492 rs28928901 GRCh37: 1:156104620-156104620
GRCh38: 1:156134829-156134829
2 LMNA NM_170707.4(LMNA):c.1445G>A (p.Arg482Gln) SNV Pathogenic 14486 rs11575937 GRCh37: 1:156106776-156106776
GRCh38: 1:156136985-156136985
3 LMNA NM_170707.4(LMNA):c.674G>A (p.Arg225Gln) SNV Pathogenic 41234 rs199474724 GRCh37: 1:156104630-156104630
GRCh38: 1:156134839-156134839
4 LMNA NM_170707.4(LMNA):c.1445G>A (p.Arg482Gln) SNV Pathogenic 14486 rs11575937 GRCh37: 1:156106776-156106776
GRCh38: 1:156136985-156136985
5 LMNA NM_170707.4(LMNA):c.1003C>T (p.Arg335Trp) SNV Pathogenic 36473 rs386134243 GRCh37: 1:156105758-156105758
GRCh38: 1:156135967-156135967
6 LMNA NM_170707.4(LMNA):c.1381-5G>A SNV Uncertain significance 180405 rs730880133 GRCh37: 1:156106707-156106707
GRCh38: 1:156136916-156136916
7 LMNA NM_170707.4(LMNA):c.1243G>A (p.Val415Ile) SNV Uncertain significance 66797 rs267607606 GRCh37: 1:156106090-156106090
GRCh38: 1:156136299-156136299
8 LMNA NM_170707.4(LMNA):c.1487C>T (p.Thr496Met) SNV Uncertain significance 245964 rs200466188 GRCh37: 1:156106818-156106818
GRCh38: 1:156137027-156137027
9 LMNA NM_170707.4(LMNA):c.1756G>A (p.Val586Met) SNV Uncertain significance 487635 rs758048062 GRCh37: 1:156108336-156108336
GRCh38: 1:156138545-156138545
10 LMNA NM_170707.4(LMNA):c.1045C>T (p.Arg349Trp) SNV not provided 66762 rs267607555 GRCh37: 1:156105800-156105800
GRCh38: 1:156136009-156136009

UniProtKB/Swiss-Prot genetic disease variations for Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive:

72
# Symbol AA change Variation ID SNP ID
1 LMNA p.Arg225Gln VAR_067697 rs199474724
2 LMNA p.Thr24Ser VAR_076562

Expression for Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive

Search GEO for disease gene expression data for Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive.

Pathways for Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive

Pathways related to Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.59 SYNE2 SYNE1 SUN2 SUN1 LMNA EMD
2
Show member pathways
11.49 SYNE2 SYNE1 SUN2 SUN1 LMNA
3
Show member pathways
10.98 LMNB2 LMNA
4
Show member pathways
10.67 LMNA EMD

GO Terms for Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive

Cellular components related to Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.2 ZMPSTE24 TMEM43 SYNE4 SYNE3 SYNE2 SYNE1
2 nucleus GO:0005634 10.18 ZMPSTE24 TMEM43 SYNE4 SYNE3 SYNE2 SYNE1
3 integral component of membrane GO:0016021 10.13 ZMPSTE24 TMEM43 SYNE4 SYNE3 SYNE2 SYNE1
4 nuclear membrane GO:0031965 9.76 SYNE3 SYNE2 SYNE1 SUN2 SUN1 LMNB2
5 nuclear inner membrane GO:0005637 9.73 ZMPSTE24 TMEM43 SUN2 SUN1 LMNB2 EMD
6 nuclear outer membrane GO:0005640 9.72 SYNE4 SYNE3 SYNE2 SYNE1 EMD
7 integral component of nuclear inner membrane GO:0005639 9.54 TMEM43 SUN2 SUN1
8 meiotic nuclear membrane microtubule tethering complex GO:0034993 9.43 SYNE4 SYNE3 SYNE2 SYNE1 SUN2 SUN1
9 nuclear envelope GO:0005635 9.32 ZMPSTE24 SYNE4 SYNE3 SYNE2 SYNE1 SUN2

Biological processes related to Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus organization GO:0006997 9.54 ZMPSTE24 SYNE1 LMNA
2 centrosome localization GO:0051642 9.5 SYNE2 SUN2 SUN1
3 mitotic nuclear envelope reassembly GO:0007084 9.46 LMNA EMD
4 nuclear membrane organization GO:0071763 9.43 TMEM43 EMD
5 nuclear migration GO:0007097 9.43 SYNE3 SYNE2 SUN2
6 nuclear migration along microfilament GO:0031022 9.4 SYNE2 SUN2
7 nuclear matrix anchoring at nuclear membrane GO:0090292 9.33 SYNE1 SUN2 SUN1
8 nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration GO:0021817 9.13 SYNE2 SUN2 SUN1
9 nuclear envelope organization GO:0006998 8.92 ZMPSTE24 SUN2 SUN1 LMNA

Molecular functions related to Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin filament binding GO:0051015 9.33 SYNE3 SYNE2 SYNE1
2 protein membrane anchor GO:0043495 8.96 SUN2 SUN1
3 lamin binding GO:0005521 8.8 SYNE1 SUN2 SUN1

Sources for Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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