MCID: ENM001
MIFTS: 31

Enamel Caries

Categories: Oral diseases

Aliases & Classifications for Enamel Caries

MalaCards integrated aliases for Enamel Caries:

Name: Enamel Caries 12 15 73
Dental Caries Limited to Enamel 12
Primary Dental Caries 12
Simple Dental Cavity 12

Classifications:



External Ids:

Disease Ontology 12 DOID:217
ICD9CM 35 521.01
SNOMED-CT 68 19437001 80353004
UMLS 73 C0266853

Summaries for Enamel Caries

MalaCards based summary : Enamel Caries, also known as dental caries limited to enamel, is related to epulis and amelogenesis imperfecta, hypoplastic/hypomaturation, x-linked 2. An important gene associated with Enamel Caries is AMELX (Amelogenin X-Linked). The drugs Chlorhexidine and Salicylic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and testes.

Related Diseases for Enamel Caries

Diseases related to Enamel Caries via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 epulis 10.1 AMELX AMELY
2 amelogenesis imperfecta, hypoplastic/hypomaturation, x-linked 2 10.1 AMELX AMELY
3 amelogenesis imperfecta 10.1 AMELX AMELY
4 freemartinism 10.1 AMELX AMELY
5 amelogenesis imperfecta, type ie 10.0 AMELX AMELY
6 retinitis pigmentosa 59 10.0 AMELX AMELY
7 dental pulp necrosis 10.0 AMELX AMELY
8 tooth resorption 10.0 AMELX AMELY
9 peptic ulcer perforation 9.9 AMELX AMELY
10 teeth hard tissue disease 9.8 AMELX AMELY GPI

Graphical network of the top 20 diseases related to Enamel Caries:



Diseases related to Enamel Caries

Symptoms & Phenotypes for Enamel Caries

Drugs & Therapeutics for Enamel Caries

Drugs for Enamel Caries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved Not Applicable 55-56-1 2713 9552079
2
Salicylic acid Approved, Investigational, Vet_approved Not Applicable 69-72-7 338
3
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
4 sodium fluoride Approved Not Applicable 7681-49-4
5
Ethanol Approved Not Applicable 64-17-5 702
6 Disinfectants Not Applicable
7 Dermatologic Agents Not Applicable
8 Chlorhexidine gluconate Not Applicable
9 Anti-Infective Agents, Local Not Applicable
10 Fluorides Not Applicable
11 Anti-Infective Agents Not Applicable
12 Calcium, Dietary Not Applicable
13 Bone Density Conservation Agents Not Applicable
14 Protective Agents Not Applicable
15 Cariostatic Agents Not Applicable
16 Anesthetics Not Applicable
17 Listerine Not Applicable
18 Keratolytic Agents Not Applicable
19 Fluorides, Topical Not Applicable
20 Antifungal Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Enamel Caries in Orthodontic Patients Completed NCT02705456 Not Applicable
2 Validation of Near-infrared Light Transillumination for Interproximal Enamel Caries Detection Completed NCT02657538 Not Applicable
3 Retention of Bonded Amalgam Sealants Versus Resin-based Sealants Completed NCT03130725 Not Applicable
4 Direct Pulp Capping With MTA and Calcium Hydroxide. Completed NCT03284697 Not Applicable
5 Hydroxyapatite-toothpaste and Enamel Caries in the Primary Dentition Recruiting NCT03553966 Not Applicable
6 Effects of Partical Excavation in One Versus Two Procedures of Primary Deep Caries (PAPRICA) Recruiting NCT03696498 Not Applicable
7 Diammine Silver Fluoride in Arresting Enamel Caries Lesions on Babies' Occlusal Surfaces Active, not recruiting NCT02789202 Not Applicable
8 Efficacy of Fluor Protector S in the Prevention in Adolescents Enrolling by invitation NCT03720379 Not Applicable
9 Effect of Different Over-the-counter Toothpastes on Enamel Remineralization Not yet recruiting NCT03774498 Not Applicable Sensodyne repair and protect

Search NIH Clinical Center for Enamel Caries

Genetic Tests for Enamel Caries

Anatomical Context for Enamel Caries

MalaCards organs/tissues related to Enamel Caries:

41
Bone, Heart, Testes

Publications for Enamel Caries

Articles related to Enamel Caries:

(show top 50) (show all 143)
# Title Authors Year
1
Synthesis of Stabilized Hydroxyapatite Nanosuspensions for Enamel Caries Remineralization. ( 29804291 )
2018
2
Natural enamel caries in quinoline: Volumetric data and the pattern of infiltration. ( 29083075 )
2018
3
High Amount of Organic Matter during Caries Formation Reduces Remineralization and Resin Infiltration of Enamel Caries. ( 29723862 )
2018
4
Effect of oral antimicrobial mouthrinses containing alcohol on viability of Streptococcus mutans and microcosm biofilm and on the prevention of enamel caries lesions. ( 30028928 )
2018
5
In vitro effect of changing the horizontal angulation of X-ray beam on the detection of proximal enamel caries in bitewing radiographs. ( 30152632 )
2018
6
In vitro remineralization of artificial enamel caries with resin composites containing calcium phosphate particles. ( 30296360 )
2018
7
The effect of diode laser irradiation associated with photoabsorbing agents containing remineralizing materials on microhardness, morphology and chemical structure of early enamel caries. ( 30386500 )
2018
8
Comparison of fluorescence parameters between three generations of QLF devices for detecting enamel caries in vitro and on smooth surfaces. ( 30508664 )
2018
9
Inhibitory effect of reduced graphene oxide-silver nanocomposite on progression of artificial enamel caries. ( 30540069 )
2018
10
Role of Candida species from HIV infected children in enamel caries lesions: an in vitro study. ( 28198976 )
2017
11
Quantitative evaluation of the enamel caries which were treated with casein phosphopeptide-amorphous calcium fluoride phosphate. ( 28656922 )
2017
12
Remineralization Potential of Three Tooth Pastes on Enamel Caries. ( 28932310 )
2017
13
Effect of Enamel Caries Lesion Baseline Severity on Fluoride Dose-Response. ( 28428800 )
2017
14
Promotion of enamel caries remineralization by an amelogenin-derived peptide in a rat model. ( 27694019 )
2017
15
Effects of Self-Assembling Peptide P11-4, Fluorides, and Caries Infiltration on Artificial Enamel Caries Lesions in vitro. ( 28772269 )
2017
16
Characterization of enamel caries lesions in rat molars using synchrotron X-ray microtomography. ( 28862629 )
2017
17
Enamel-Caries Prevention Using Two Applications of Fluoride-Laser Sequence. ( 27188011 )
2016
18
Galla chinensis Compounds Remineralize Enamel Caries Lesions in a Rat Model. ( 27111668 )
2016
19
Effect of xylitol varnishes on remineralization of artificial enamel caries lesions in situ. ( 27032722 )
2016
20
Effect of ozone to remineralize initial enamel caries: in situ study. ( 26759338 )
2016
21
In vitro re-hardening of artificial enamel caries lesions using enamel matrix proteins or self-assembling peptides. ( 27008255 )
2016
22
The efficiency of child formula dentifrices containing different calcium and phosphate compounds on artificial enamel caries. ( 28032049 )
2016
23
Surface Roughness of Initial Enamel Caries Lesions in Human Teeth After Resin Infiltration. ( 27733877 )
2016
24
Remineralization of early enamel caries lesions using different bioactive elements containing toothpastes: An in vitro study. ( 27233091 )
2016
25
Infrared Methods for Assessment of the Activity of Natural Enamel Caries Lesions. ( 27642246 )
2016
26
Effects of dentifrices differing in fluoride compounds on artificial enamel caries lesions in vitro. ( 26849573 )
2016
27
Bond Strength of Experimental Low-viscosity Resin Materials to Early Enamel Caries Lesions: Effect of Diluent/Solvent Addition. ( 25830164 )
2015
28
Predicting infiltration of the surface layer of natural enamel caries. ( 25804561 )
2015
29
Different bacterial models for in vitro induction of non-cavitated enamel caries-like lesions: Microhardness and polarized light miscroscopy analyses. ( 25783414 )
2015
30
Remineralizing efficacy of a CPP-ACP cream on enamel caries lesions in situ. ( 25427566 )
2015
31
Evaluation of dental enamel caries assessment using Quantitative Light Induced Fluorescence and Optical Coherence Tomography. ( 26351155 )
2015
32
Remineralizing Effect of Child Formula Dentifrices on Artificial Enamel Caries Using a pH Cycling Model. ( 26005449 )
2015
33
The effect of various model parameters on enamel caries lesions in a dose-response model in situ. ( 26275928 )
2015
34
Potential of an amelogenin based peptide in promoting reminerlization of initial enamel caries. ( 26263536 )
2015
35
Influence of CO2 (10.6 μm) and Nd:YAG laser irradiation on the prevention of enamel caries around orthodontic brackets. ( 23812850 )
2015
36
Comparative evaluation of the effect of Er:YAG laser and low level laser irradiation combined with CPP-ACPF cream on treatment of enamel caries. ( 24790710 )
2014
37
The preventive effect of grape seed extract on artificial enamel caries progression in a microbial biofilm-induced caries model. ( 24863939 )
2014
38
Effect of three different remineralizing agents on enamel caries formation--an in vitro study. ( 25219988 )
2014
39
8DSS-promoted remineralization of initial enamel caries in vitro. ( 24496294 )
2014
40
Effect of xylitol varnishes on remineralization of artificial enamel caries lesions in vitro. ( 25152511 )
2014
41
Dentist and practice characteristics associated with restorative treatment of enamel caries in permanent teeth: multiple-regression modeling of observational clinical data from the National Dental PBRN. ( 25000667 )
2014
42
Natural enamel caries: a comparative histological study on biochemical volumes. ( 23222001 )
2013
43
Evaluation of polymerization characteristics and penetration into enamel caries lesions of experimental infiltrants. ( 24004967 )
2013
44
A defined-multispecies microbial model for studying enamel caries development. ( 23446436 )
2013
45
Influence of Er,Cr:YSGG laser irradiation on enamel caries prevention. ( 22350424 )
2013
46
Effects of regular and highly fluoridated toothpastes in combination with saliva substitutes on artificial enamel caries lesions differing in mineral content. ( 22398123 )
2012
47
Natural enamel caries in polarized light microscopy: differences in histopathological features derived from a qualitative versus a quantitative approach to interpret enamel birefringence. ( 22414271 )
2012
48
Performance of laser fluorescence for the detection of enamel caries in non-cavitated occlusal surfaces: clinical study with total validation of the sample. ( 22558692 )
2012
49
Fluoride dose-response of human and bovine enamel caries lesions under remineralizing conditions. ( 23082383 )
2012
50
Detection of cavitated or non-cavitated approximal enamel caries lesions using CMOS and CCD digital X-ray sensors and conventional D and F-speed films at different exposure conditions. ( 21698985 )
2011

Variations for Enamel Caries

Expression for Enamel Caries

Search GEO for disease gene expression data for Enamel Caries.

Pathways for Enamel Caries

GO Terms for Enamel Caries

Cellular components related to Enamel Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 8.8 AMELX AMELY SDC3

Biological processes related to Enamel Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium ion transport GO:0006814 8.96 SLC13A2 SLC13A5
2 biomineral tissue development GO:0031214 8.62 AMELX AMELY

Molecular functions related to Enamel Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.16 AMELX GPI
2 symporter activity GO:0015293 8.96 SLC13A2 SLC13A5
3 structural constituent of tooth enamel GO:0030345 8.62 AMELX AMELY

Sources for Enamel Caries

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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