MCID: ENM001
MIFTS: 28

Enamel Caries

Categories: Oral diseases

Aliases & Classifications for Enamel Caries

MalaCards integrated aliases for Enamel Caries:

Name: Enamel Caries 12 15 70
Dental Caries Limited to Enamel 12
Primary Dental Caries 12
Simple Dental Cavity 12

Classifications:



External Ids:

Disease Ontology 12 DOID:217
ICD9CM 34 521.01
SNOMED-CT 67 80353004
UMLS 70 C0266853

Summaries for Enamel Caries

MalaCards based summary : Enamel Caries, also known as dental caries limited to enamel, is related to dental caries and dentin caries. An important gene associated with Enamel Caries is AMELX (Amelogenin X-Linked). The drugs sodium fluoride and Salicylic acid have been mentioned in the context of this disorder. Affiliated tissues include bone.

Related Diseases for Enamel Caries

Diseases related to Enamel Caries via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 dental caries 29.6 TUFT1 STATH ENAM DMBT1 AMELX AMBN
2 dentin caries 10.2
3 dental pulp calcification 10.2 ENAM AMELX
4 palmoplantar keratoderma, nonepidermolytic, focal or diffuse 10.1 TUFT1 AMELX
5 hermansky-pudlak syndrome 6 10.1 AMELX AMBN
6 root caries 10.1 STATH AMELX
7 craniopharyngioma 10.1 MMP20 ENAM
8 hypoplastic amelogenesis imperfecta 10.0 ENAM AMBN
9 tooth resorption 10.0 AMELX AMBN
10 pulp degeneration 10.0 ENAM AMELX AMBN
11 bone benign neoplasm 10.0 AMELX AMBN
12 amelogenesis imperfecta hypomaturation type 10.0 MMP20 AMELX
13 amelogenesis imperfecta, type ib 10.0 ENAM AMELX AMBN
14 amelogenesis imperfecta, hypoplastic/hypomaturation, x-linked 2 10.0 TUFT1 AMELX AMBN
15 adamantinous craniopharyngioma 10.0 MMP20 ENAM
16 disease by infectious agent 10.0
17 amelogenesis imperfecta, type ie 9.9 TUFT1 AMELX AMBN
18 amelogenesis imperfecta, type ic 9.9 MMP20 ENAM AMELX
19 papillary craniopharyngioma 9.9 MMP20 ENAM AMELX
20 enamel erosion 9.9 STATH MMP20 AMELX
21 ameloblastoma 9.9 MMP20 AMELX AMBN
22 jalili syndrome 9.8 MMP20 ENAM
23 dentine erosion 9.8 TUFT1 ENAM AMELX AMBN
24 hypercementosis 9.7 MMP20 ENAM AMELX AMBN
25 trichodentoosseous syndrome 9.7 MMP20 ENAM AMELX AMBN
26 dental fluorosis 9.7 MMP20 ENAM AMELX AMBN
27 dentin dysplasia 9.7 MMP20 ENAM AMELX AMBN
28 amelogenesis imperfecta, type iiia 9.7 MMP20 ENAM AMELX AMBN
29 junctional epidermolysis bullosa 9.7 MMP20 ENAM AMELX AMBN
30 tooth agenesis 9.7 MMP20 ENAM AMELX AMBN
31 tooth disease 9.6 ENAM AMELX AMBN
32 tooth erosion 9.6 TUFT1 STATH ENAM AMELX AMBN
33 amelogenesis imperfecta 9.5 TUFT1 MMP20 ENAM AMELX AMBN
34 teeth hard tissue disease 8.9 TUFT1 STATH MMP20 ENAM DMBT1 AMELX

Graphical network of the top 20 diseases related to Enamel Caries:



Diseases related to Enamel Caries

Symptoms & Phenotypes for Enamel Caries

Drugs & Therapeutics for Enamel Caries

Drugs for Enamel Caries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
sodium fluoride Approved 7681-49-4
2
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
3
Chlorhexidine Approved, Vet_approved 55-56-1 9552079 2713
4 Listerine
5 Fluorides, Topical
6 Protective Agents
7 Fluorophosphate
8 Fluorides
9 Chlorhexidine gluconate
10 Anesthetics
11 Calcium, Dietary
12
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Different Over-the-counter Toothpastes on Enamel Remineralization: A Double Blinded Randomized Clinical Trial Unknown status NCT03774498 Sensodyne repair and protect
2 Efficacy, Cost-efficacy and Parental Acceptability of Using Diammine Silver Fluoride in Arresting Enamel Caries Lesions on Babies' Occlusal Surfaces Unknown status NCT02789202
3 Comparison of Six Months Retention of Bonded Amalgam Sealants Versus Resin-based Sealants: A Randomized Controlled Trial Completed NCT03130725
4 Evaluation of Hall Technique and Atraumatic Restorative Treatment for Management of Caries in the Primary Dentition (A Randomized Controlled Clinical Trial) Completed NCT04367649
5 An in Situ Clinical Trial to Evaluate the Efficacy of a Calcium and Phosphate Enriched Sodium Monofluorophosphate Toothpaste on Enamel Lesion Remineralisation Completed NCT04155658
6 Enamel Caries in Orthodontic Patients Completed NCT02705456
7 Impact of the Daily Use of Hydroxyapatite-toothpaste on the Occurrence of Enamel Caries in the Primary Dentition (ECIPDEN17) Completed NCT03553966
8 Validation of Near-infrared Light Transillumination for Interproximal Enamel Caries Detection: A Clinical Controlled Trial Completed NCT02657538
9 Effects of PArtial Excavation in One Procedure Versus Partial Excavation in Two Procedures of PRImary Deep CAries in Permanent Teeth - A Randomised, Multicenter Clinical Superiority Trial With Blinded Outcome Assessment Recruiting NCT03696498

Search NIH Clinical Center for Enamel Caries

Genetic Tests for Enamel Caries

Anatomical Context for Enamel Caries

MalaCards organs/tissues related to Enamel Caries:

40
Bone

Publications for Enamel Caries

Articles related to Enamel Caries:

(show top 50) (show all 582)
# Title Authors PMID Year
1
Dental caries thresholds among adolescents in England, Wales, and Northern Ireland, 2013 at 12, and 15 years: implications for epidemiology and clinical care. 61
33740952 2021
2
Comparison of novel and established caries diagnostic methods: a clinical study on occlusal surfaces. 61
33663454 2021
3
Electrical conductance for the detection of dental caries. 61
33724442 2021
4
Imaging modalities to inform the detection and diagnosis of early caries. 61
33720395 2021
5
Self-assembling peptide P11-4 in remineralization of enamel caries - a systematic review of in-vitro studies. 61
33026894 2021
6
Efficacy of a self-assembling peptide to remineralize initial caries lesions - a systematic review and meta-analysis. 61
33798639 2021
7
Effects of healthcare policy and education on reading accuracy of bitewing radiographs for interproximal caries. 61
32795199 2021
8
Building an aprismatic enamel-like layer on a demineralized enamel surface by using carboxymethyl chitosan and lysozyme-encapsulated amorphous calcium phosphate nanogels. 61
33561513 2021
9
Characteristics of teenagers who use dental floss. 61
32407009 2021
10
Presence of Interproximal Carious Lesions in Primary Molars. 61
33662247 2021
11
Impact of a toothpaste with microcrystalline hydroxyapatite on the occurrence of early childhood caries: a 1-year randomized clinical trial. 61
33514787 2021
12
COMPARATIVE EVALUATION OF THE CLINICAL EFFICACY OF MODERN REMINERALIZING DRUGS IN THE TREATMENT OF ENAMEL CARIES (FOCAL DEMINERALIZATION). 61
33658407 2021
13
Transillumination and optical coherence tomography for the detection and diagnosis of enamel caries. 61
33502759 2021
14
In vitro demineralization prevention by fluoride and silver nanoparticles when applied to sound enamel and enamel caries-like lesions of varying severities. 61
33217487 2021
15
Preventing Enamel Caries Using Carbon Dioxide Laser and Silver Diamine Fluoride. 61
33373541 2020
16
Fluorescence devices for the detection of dental caries. 61
33319353 2020
17
Do bleaching gels affect the stability of the masking and caries-arresting effects of caries infiltration-in vitro. 61
33319337 2020
18
Association between coronal caries and malocclusion in an adult population. 61
33337523 2020
19
Evidence-based consensus for treating incipient enamel caries in adults by non-invasive methods: recommendations by GRADE guideline. 61
33294058 2020
20
Tuftelin-derived peptide facilitates remineralization of initial enamel caries in vitro. 61
32524721 2020
21
Validity of micro-CT for in vitro caries detection: a systematic review and meta-analysis. 61
31709810 2020
22
Do enamel and dentine caries at 5 years of age predict caries development in newly erupted teeth? A prospective longitudinal study. 61
32189539 2020
23
Study of Demineralized Dental Enamel Treated with Different Fluorinated Compounds by Raman Spectroscopy. 61
33134223 2020
24
Monitoring enamel caries on resin-treated occlusal surfaces using quantitative light-induced fluorescence: an in vitro study. 61
32382936 2020
25
Bacteriologic status of non-cavitated proximal enamel caries lesions. A histologic and histobacteriologic study. 61
32615236 2020
26
Clinical performance of clinical-visual examination, digital bitewing radiography, laser fluorescence, and near-infrared light transillumination for detection of non-cavitated proximal enamel and dentin caries. 61
32333336 2020
27
3D imaging of proximal caries in posterior teeth using optical coherence tomography. 61
32978464 2020
28
Diagnostic Performance of ICDAS II, FluoreCam and Ultrasound for Flat Surface Caries with Different Depths. 61
32376191 2020
29
Anti-caries effect of resin infiltrant modified by quaternary ammonium monomers. 61
32380134 2020
30
Effect of Resin Infiltration Technique on Improving Surface Hardness of Enamel Lesions: A Systematic Review and Meta-analysis. 61
32473796 2020
31
In vitro CO2 9.3-μm short-pulsed laser caries prevention-effects of a newly developed laser irradiation pattern. 61
31897815 2020
32
Hydrolytic degradation of different infiltrant compositions within different histological zones of enamel caries like-lesions. 61
31723096 2020
33
Remineralization of enamel caries by an amelogenin-derived peptide and fluoride in vitro. 61
32523730 2020
34
An In Vivo Investigation of Diagnostic Performance of DIAGNOdent Pen and the Canary System for Assessment and Monitoring Enamel Caries under Fissure Sealants. 61
32802769 2020
35
Saliva proteomics from children with caries at different severity stages. 61
32285988 2020
36
Diagnosis of Occlusal Caries with Dynamic Slicing of 3D Optical Coherence Tomography Images. 61
32192069 2020
37
Remineralization effectiveness of the PAMAM dendrimer with different terminal groups on artificial initial enamel caries in vitro. 61
31785833 2020
38
Laser-assisted prevention of enamel caries: a 10-year review of the literature. 61
31399861 2020
39
Influence of salivary conditioning and sucrose concentration on biofilm-mediated enamel demineralization. 61
32236356 2020
40
Ex vivo investigation on internal tunnel approach/internal resin infiltration and external nanosilver-modified resin infiltration of proximal caries exceeding into dentin. 61
31990942 2020
41
Quantitative evaluation of masking effect of resin infiltration on developmental defects of enamel. 61
32368763 2020
42
Rational Design of β-sheet Peptides with Self-Assembly into Nanofibres on Remineralisation of Initial Caries Lesions. 61
32548604 2020
43
Enamel and Dentin Caries Risk Factors of Adolescents in the Context of the International Caries Detection and Assessment System (ICDAS): A Longitudinal Study. 61
32850535 2020
44
Accurate Detection of Non-Cavitated Proximal Caries in Posterior Permanent Teeth: An in vivo Study. 61
32943960 2020
45
Synthesis of plate-like β-tricalcium phosphate nanoparticles and their efficiency in remineralization of incipient enamel caries. 61
31813116 2019
46
Remineralization of early enamel caries lesions induced by bioactive particles: An in vitro speckle analysis. 61
31377473 2019
47
The effects of sodium hexametaphosphate combined with other remineralizing agents on the staining and microhardness of early enamel caries: An in vitro modified pH-cycling model. 61
31803386 2019
48
Effectiveness of Theobromine on Enamel Remineralization: A Comparative In-vitro Study. 61
31720155 2019
49
Remineralization potential of dentifrice containing nanohydroxyapatite on artificial carious lesions of enamel: A comparative in vitro study. 61
31543937 2019
50
A comparative quantitative & qualitative assessment in orthodontic treatment of white spot lesion treated with 3 different commercially available materials - In vitro study. 61
31636868 2019

Variations for Enamel Caries

Expression for Enamel Caries

Search GEO for disease gene expression data for Enamel Caries.

Pathways for Enamel Caries

GO Terms for Enamel Caries

Cellular components related to Enamel Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 TUFT1 STATH MMP20 ENAM DMBT1 AMELX
2 endoplasmic reticulum lumen GO:0005788 9.33 ENAM AMELX AMBN
3 extracellular matrix GO:0031012 8.92 MMP20 ENAM DMBT1 AMELX

Biological processes related to Enamel Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.5 ENAM AMELX AMBN
2 odontogenesis of dentin-containing tooth GO:0042475 9.26 AMELX AMBN
3 cellular protein metabolic process GO:0044267 9.26 ENAM DMBT1 AMELX AMBN
4 amelogenesis GO:0097186 9.16 MMP20 ENAM
5 biomineral tissue development GO:0031214 9.02 TUFT1 STATH ENAM AMELX AMBN

Molecular functions related to Enamel Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of tooth enamel GO:0030345 9.02 TUFT1 STATH ENAM AMELX AMBN
2 hydroxyapatite binding GO:0046848 8.96 STATH AMELX

Sources for Enamel Caries

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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