MCID: ENM001
MIFTS: 29

Enamel Caries

Categories: Oral diseases

Aliases & Classifications for Enamel Caries

MalaCards integrated aliases for Enamel Caries:

Name: Enamel Caries 12 15 74
Dental Caries Limited to Enamel 12
Primary Dental Caries 12
Simple Dental Cavity 12

Classifications:



External Ids:

Disease Ontology 12 DOID:217
ICD9CM 36 521.01
SNOMED-CT 69 19437001 80353004
UMLS 74 C0266853

Summaries for Enamel Caries

MalaCards based summary : Enamel Caries, also known as dental caries limited to enamel, is related to epulis and dental caries. An important gene associated with Enamel Caries is DES (Desmin). The drugs Chlorhexidine and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include bone and testes.

Related Diseases for Enamel Caries

Diseases related to Enamel Caries via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 epulis 10.0 AMELX DES
2 dental caries 9.9
3 amelogenesis imperfecta, type iiia 9.8 AMBN AMELX
4 dentine erosion 9.8 AMBN GPI
5 amelogenesis imperfecta 9.7 AMBN AMELX
6 amelogenesis imperfecta, hypoplastic/hypomaturation, x-linked 2 9.7 AMBN AMELX
7 dental pulp necrosis 9.7 AMBN AMELX
8 dental fluorosis 9.5 AMBN AMELX
9 teeth hard tissue disease 9.5 AMBN AMELX GPI

Graphical network of the top 20 diseases related to Enamel Caries:



Diseases related to Enamel Caries

Symptoms & Phenotypes for Enamel Caries

Drugs & Therapeutics for Enamel Caries

Drugs for Enamel Caries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved Not Applicable 55-56-1 2713 9552079
2
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
3 sodium fluoride Approved Not Applicable 7681-49-4
4
Salicylic acid Approved, Investigational, Vet_approved Not Applicable 69-72-7 338
5
Ethanol Approved Not Applicable 64-17-5 702
6
Calcium Approved, Nutraceutical Not Applicable 7440-70-2 271
7 Anti-Infective Agents, Local Not Applicable
8 Chlorhexidine gluconate Not Applicable
9 Anti-Infective Agents Not Applicable
10 Disinfectants Not Applicable
11 Dermatologic Agents Not Applicable
12 Fluorides Not Applicable
13 Calcium, Dietary Not Applicable
14 Hormones Not Applicable
15 Bone Density Conservation Agents Not Applicable
16 Cariostatic Agents Not Applicable
17 Protective Agents Not Applicable
18 Anesthetics Not Applicable
19 Fluorides, Topical Not Applicable
20 Listerine Not Applicable
21 Keratolytic Agents Not Applicable
22 Antifungal Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Enamel Caries in Orthodontic Patients Completed NCT02705456 Not Applicable
2 Validation of Near-infrared Light Transillumination for Interproximal Enamel Caries Detection Completed NCT02657538 Not Applicable
3 Retention of Bonded Amalgam Sealants Versus Resin-based Sealants Completed NCT03130725 Not Applicable
4 Direct Pulp Capping With MTA and Calcium Hydroxide. Completed NCT03284697 Not Applicable
5 Hydroxyapatite-toothpaste and Enamel Caries in the Primary Dentition Recruiting NCT03553966 Not Applicable
6 Effects of Partical Excavation in One Versus Two Procedures of Primary Deep Caries (PAPRICA) Recruiting NCT03696498 Not Applicable
7 Diammine Silver Fluoride in Arresting Enamel Caries Lesions on Babies' Occlusal Surfaces Active, not recruiting NCT02789202 Not Applicable
8 Efficacy of Fluor Protector S in the Prevention in Adolescents Enrolling by invitation NCT03720379 Not Applicable
9 Effect of Different Over-the-counter Toothpastes on Enamel Remineralization Not yet recruiting NCT03774498 Not Applicable Sensodyne repair and protect

Search NIH Clinical Center for Enamel Caries

Genetic Tests for Enamel Caries

Anatomical Context for Enamel Caries

MalaCards organs/tissues related to Enamel Caries:

42
Bone, Testes

Publications for Enamel Caries

Articles related to Enamel Caries:

(show top 50) (show all 149)
# Title Authors Year
1
Impact of a non-fluoridated microcrystalline hydroxyapatite dentifrice on enamel caries progression in highly caries-susceptible orthodontic patients: A randomized, controlled 6-month trial. ( 30701704 )
2019
2
Evaluation of novel nanoscaled metal fluorides on their ability to remineralize enamel caries lesions. ( 30760851 )
2019
3
The effects of 8DSS peptide on remineralization in a rat mod of enamel caries evaluated by two nondestructive techniques. ( 30808229 )
2019
4
Natural enamel caries, dentine reactions, dentinal fluid and biofilm. ( 30808878 )
2019
5
Influence of infiltrant application time on the reduction of opaqueness of proximal enamel caries. ( 30900657 )
2019
6
Near-Infrared Imaging of Artificial Enamel Caries Lesions with a Scanning Fiber Endoscope. ( 30909442 )
2019
7
Synthesis of Stabilized Hydroxyapatite Nanosuspensions for Enamel Caries Remineralization. ( 29804291 )
2018
8
Natural enamel caries in quinoline: Volumetric data and the pattern of infiltration. ( 29083075 )
2018
9
High Amount of Organic Matter during Caries Formation Reduces Remineralization and Resin Infiltration of Enamel Caries. ( 29723862 )
2018
10
Effect of oral antimicrobial mouthrinses containing alcohol on viability of Streptococcus mutans and microcosm biofilm and on the prevention of enamel caries lesions. ( 30028928 )
2018
11
In vitro effect of changing the horizontal angulation of X-ray beam on the detection of proximal enamel caries in bitewing radiographs. ( 30152632 )
2018
12
In vitro remineralization of artificial enamel caries with resin composites containing calcium phosphate particles. ( 30296360 )
2018
13
The effect of diode laser irradiation associated with photoabsorbing agents containing remineralizing materials on microhardness, morphology and chemical structure of early enamel caries. ( 30386500 )
2018
14
Comparison of fluorescence parameters between three generations of QLF devices for detecting enamel caries in vitro and on smooth surfaces. ( 30508664 )
2018
15
Inhibitory effect of reduced graphene oxide-silver nanocomposite on progression of artificial enamel caries. ( 30540069 )
2018
16
Role of Candida species from HIV infected children in enamel caries lesions: an in vitro study. ( 28198976 )
2017
17
Quantitative evaluation of the enamel caries which were treated with casein phosphopeptide-amorphous calcium fluoride phosphate. ( 28656922 )
2017
18
Remineralization Potential of Three Tooth Pastes on Enamel Caries. ( 28932310 )
2017
19
Effect of Enamel Caries Lesion Baseline Severity on Fluoride Dose-Response. ( 28428800 )
2017
20
Promotion of enamel caries remineralization by an amelogenin-derived peptide in a rat model. ( 27694019 )
2017
21
Effects of Self-Assembling Peptide P11-4, Fluorides, and Caries Infiltration on Artificial Enamel Caries Lesions in vitro. ( 28772269 )
2017
22
Characterization of enamel caries lesions in rat molars using synchrotron X-ray microtomography. ( 28862629 )
2017
23
Enamel-Caries Prevention Using Two Applications of Fluoride-Laser Sequence. ( 27188011 )
2016
24
Galla chinensis Compounds Remineralize Enamel Caries Lesions in a Rat Model. ( 27111668 )
2016
25
Effect of xylitol varnishes on remineralization of artificial enamel caries lesions in situ. ( 27032722 )
2016
26
Effect of ozone to remineralize initial enamel caries: in situ study. ( 26759338 )
2016
27
In vitro re-hardening of artificial enamel caries lesions using enamel matrix proteins or self-assembling peptides. ( 27008255 )
2016
28
The efficiency of child formula dentifrices containing different calcium and phosphate compounds on artificial enamel caries. ( 28032049 )
2016
29
Surface Roughness of Initial Enamel Caries Lesions in Human Teeth After Resin Infiltration. ( 27733877 )
2016
30
Remineralization of early enamel caries lesions using different bioactive elements containing toothpastes: An in vitro study. ( 27233091 )
2016
31
Infrared Methods for Assessment of the Activity of Natural Enamel Caries Lesions. ( 27642246 )
2016
32
Effects of dentifrices differing in fluoride compounds on artificial enamel caries lesions in vitro. ( 26849573 )
2016
33
Bond Strength of Experimental Low-viscosity Resin Materials to Early Enamel Caries Lesions: Effect of Diluent/Solvent Addition. ( 25830164 )
2015
34
Predicting infiltration of the surface layer of natural enamel caries. ( 25804561 )
2015
35
Different bacterial models for in vitro induction of non-cavitated enamel caries-like lesions: Microhardness and polarized light miscroscopy analyses. ( 25783414 )
2015
36
Remineralizing efficacy of a CPP-ACP cream on enamel caries lesions in situ. ( 25427566 )
2015
37
Evaluation of dental enamel caries assessment using Quantitative Light Induced Fluorescence and Optical Coherence Tomography. ( 26351155 )
2015
38
Remineralizing Effect of Child Formula Dentifrices on Artificial Enamel Caries Using a pH Cycling Model. ( 26005449 )
2015
39
The effect of various model parameters on enamel caries lesions in a dose-response model in situ. ( 26275928 )
2015
40
Potential of an amelogenin based peptide in promoting reminerlization of initial enamel caries. ( 26263536 )
2015
41
Comparative evaluation of the effect of Er:YAG laser and low level laser irradiation combined with CPP-ACPF cream on treatment of enamel caries. ( 24790710 )
2014
42
The preventive effect of grape seed extract on artificial enamel caries progression in a microbial biofilm-induced caries model. ( 24863939 )
2014
43
Effect of three different remineralizing agents on enamel caries formation--an in vitro study. ( 25219988 )
2014
44
8DSS-promoted remineralization of initial enamel caries in vitro. ( 24496294 )
2014
45
Effect of xylitol varnishes on remineralization of artificial enamel caries lesions in vitro. ( 25152511 )
2014
46
Dentist and practice characteristics associated with restorative treatment of enamel caries in permanent teeth: multiple-regression modeling of observational clinical data from the National Dental PBRN. ( 25000667 )
2014
47
Natural enamel caries: a comparative histological study on biochemical volumes. ( 23222001 )
2013
48
Evaluation of polymerization characteristics and penetration into enamel caries lesions of experimental infiltrants. ( 24004967 )
2013
49
A defined-multispecies microbial model for studying enamel caries development. ( 23446436 )
2013
50
Influence of Er,Cr:YSGG laser irradiation on enamel caries prevention. ( 22350424 )
2013

Variations for Enamel Caries

Expression for Enamel Caries

Search GEO for disease gene expression data for Enamel Caries.

Pathways for Enamel Caries

GO Terms for Enamel Caries

Cellular components related to Enamel Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell junction GO:0005911 8.62 DES PARD3

Biological processes related to Enamel Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.43 AMBN AMELX PARD3
2 regulation of signaling receptor activity GO:0010469 9.33 AMBN AMELX GPI
3 odontogenesis of dentin-containing tooth GO:0042475 8.96 AMBN AMELX
4 biomineral tissue development GO:0031214 8.62 AMBN AMELX

Molecular functions related to Enamel Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.46 AMELX DES PARD3 SDC3
2 growth factor activity GO:0008083 9.13 AMBN AMELX GPI
3 structural constituent of tooth enamel GO:0030345 8.62 AMBN AMELX

Sources for Enamel Caries

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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