MCID: ENM002
MIFTS: 29

Enamel Erosion

Categories: Oral diseases

Aliases & Classifications for Enamel Erosion

MalaCards integrated aliases for Enamel Erosion:

Name: Enamel Erosion 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:2497
ICD9CM 36 521.31
UMLS 74 C1456161

Summaries for Enamel Erosion

MalaCards based summary : Enamel Erosion is related to spondyloenchondrodysplasia and dentine erosion. An important gene associated with Enamel Erosion is GPI (Glucose-6-Phosphate Isomerase), and among its related pathways/superpathways are BRCA1 Pathway and Transcription Ligand-dependent activation of the ESR1/SP pathway. The drugs sodium fluoride and Protective Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, and related phenotypes are homeostasis/metabolism and mortality/aging

Related Diseases for Enamel Erosion

Graphical network of the top 20 diseases related to Enamel Erosion:



Diseases related to Enamel Erosion

Symptoms & Phenotypes for Enamel Erosion

MGI Mouse Phenotypes related to Enamel Erosion:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.43 GPI LPP MTF1 RASIP1 SMARCA2 SMARCA4
2 mortality/aging MP:0010768 9.1 GPI LPP MTF1 RASIP1 SMARCA2 SMARCA4

Drugs & Therapeutics for Enamel Erosion

Drugs for Enamel Erosion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 sodium fluoride Approved Phase 3,Phase 2,Not Applicable 7681-49-4
2 Protective Agents Phase 3,Phase 2,Not Applicable
3 Anti-Infective Agents, Local Phase 3,Phase 2,Not Applicable
4 Cariostatic Agents Phase 3,Phase 2,Not Applicable
5 Listerine Phase 3,Phase 2,Not Applicable
6 Anti-Infective Agents Phase 3,Phase 2,Not Applicable
7 Fluorides Phase 3,Phase 2,Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Fluoride in a Dentifrice on Remineralization of Erosive Lesions Completed NCT01641237 Phase 3 sodium fluoride;no added fluoride in a silica base
2 Evaluation of a Test Mouthwash and Dentifrice Regimen in an In-situ Model of Dental Erosion Completed NCT01128972 Phase 2 Sodium fluoride;Sodium monoflurophosphate;Sterile water
3 Preliminary Clinical Study of Ultrasound to Measure Enamel Thickness Completed NCT01622920 Phase 1
4 In Vivo Investigation of Initial Stages of Enamel Erosion Completed NCT02533466 Not Applicable

Search NIH Clinical Center for Enamel Erosion

Genetic Tests for Enamel Erosion

Anatomical Context for Enamel Erosion

MalaCards organs/tissues related to Enamel Erosion:

42
Testes

Publications for Enamel Erosion

Articles related to Enamel Erosion:

(show top 50) (show all 165)
# Title Authors Year
1
Learning how to reverse early enamel erosion. ( 31076708 )
2019
2
Effect of Er,Cr:YSGG on Remineralization Using CPP - ACPF (MI - Paste Plus) after Enamel Erosion Caused by Carbonated Soft Drink in Primary Teeth: In-Vitro Study. ( 31049105 )
2019
3
Learning how to reverse early enamel erosion. ( 31028334 )
2019
4
Effect of different protective agents on enamel erosion: An in vitro investigation. ( 30805114 )
2019
5
Effect of Er,Cr:YSGG laser associated with fluoride on the control of enamel erosion progression. ( 30690411 )
2019
6
Randomized in situ study on the efficacy of CO2 laser irradiation in increasing enamel erosion resistance. ( 30267277 )
2019
7
Influence of Surfactants and Fluoride against Enamel Erosion. ( 29874648 )
2019
8
Towards quantitative analysis of enamel erosion by focused ion beam tomography. ( 30301623 )
2018
9
Comparative evaluation of grape seed and cranberry extracts in preventing enamel erosion: An optical emission spectrometric analysis. ( 30294113 )
2018
10
Effect of Mouthrinses containing Olive Oil, Fluoride, and Their Combination on Enamel Erosion: An in vitro Study. ( 29422460 )
2018
11
ATR-FTIR spectroscopy and μ-EDXRF spectrometry monitoring of enamel erosion caused by medicaments used in the treatment of respiratory diseases. ( 29134721 )
2018
12
Fluoride toothpastes containing micrometric or nano-sized sodium trimetaphosphate reduce enamel erosion in vitro. ( 29037096 )
2018
13
New survey reveals lack of knowledge about enamel erosion. ( 29795513 )
2018
14
Effect of Fluoride Varnish Containing CPP-ACP on Preventing Enamel Erosion. ( 29109803 )
2017
15
Effects of tannin-fluoride and milk-fluoride mixture on human enamel erosion from inappropriately chlorinated pool water. ( 28904314 )
2017
16
Remineralizing effect of a zinc-hydroxyapatite toothpaste on enamel erosion caused by soft drinks: Ultrastructural analysis. ( 28828151 )
2017
17
A New Laser-Processing Strategy for Improving Enamel Erosion Resistance. ( 28665779 )
2017
18
Quantitative Swept-Source Optical Coherence Tomography of Early Enamel Erosion in vivo. ( 28637033 )
2017
19
Erratum to: Nd:YAG laser irradiation associated with fluoridated gels containing photo absorbers in the prevention of enamel erosion. ( 28634633 )
2017
20
In situ evaluation of fluoride-, stannous- and polyphosphate-containing solutions against enamel erosion. ( 28552363 )
2017
21
Nd:YAG laser irradiation associated with fluoridated gels containing photo absorbers in the prevention of enamel erosion. ( 28500516 )
2017
22
Effect of CPP-ACP or a Potassium Nitrate Sodium Fluoride Dentifrice on Enamel Erosion Prevention. ( 28288296 )
2017
23
AmF/NaF/SnCl2 solution reduces in situ enamel erosion - profilometry and cross-sectional nanoindentation analysis. ( 28273206 )
2017
24
A novel approach to study in situ enamel erosion and abrasion lesions. ( 28232081 )
2017
25
In vitro enamel erosion and abrasion-inhibiting effect of different fluoride varnishes. ( 28167334 )
2017
26
Protective effect of zinc-hydroxyapatite toothpastes on enamel erosion: An in vitro study. ( 28149475 )
2017
27
Frequency of Application of AmF/NaF/SnCl2 Solution and Its Potential in Controlling Human Enamel Erosion Progression: An in situ Study. ( 28125809 )
2017
28
In situ effect of a CPP-ACP chewing gum on enamel erosion associated or not with abrasion. ( 27020912 )
2017
29
Protective effects of a zinc-hydroxyapatite toothpaste on enamel erosion: SEM study. ( 28149449 )
2016
30
Toothpastes and enamel erosion/abrasion - Impact of active ingredients and the particulate fraction. ( 27650640 )
2016
31
Influence of Calcium Phosphate and Apatite Containing Products on Enamel Erosion. ( 27430013 )
2016
32
Analysis of the Early Stages and Evolution of Dental Enamel Erosion. ( 27224566 )
2016
33
A new hand-held optical reflectometer to measure enamel erosion: correlation with surface hardness and calcium release. ( 27121129 )
2016
34
A simple, sensitive and non-destructive technique for characterizing bovine dental enamel erosion: attenuated total reflection Fourier transform infrared spectroscopy. ( 27025266 )
2016
35
Effect of self-assembling peptide P11 -4 on enamel erosion: AFM and SEM studies. ( 26435410 )
2016
36
Enamel erosion and mechanical tooth wear in medieval Icelanders. ( 26358010 )
2016
37
Effect of High-Fluoride Dentifrice on Enamel Erosion Adjacent to Restorations In Vitro. ( 26266646 )
2016
38
Effect of home-bleaching gels modified by calcium and/or fluoride and the application of nano-hydroxyapatite paste on in vitro enamel erosion susceptibility. ( 26083582 )
2016
39
Sequence of stannous and sodium fluoride solutions to prevent enamel erosion. ( 26454222 )
2015
40
Combined Tin-Containing Fluoride Solution and CO2 Laser Treatment Reduces Enamel Erosion in vitro. ( 26418736 )
2015
41
Effect of sodium fluoride and stannous chloride associated with Nd:YAG laser irradiation on the progression of enamel erosion. ( 26227298 )
2015
42
In vitro effect of low-fluoride toothpastes containing sodium trimetaphosphate on enamel erosion. ( 26092765 )
2015
43
CO₂ laser emission modes to control enamel erosion. ( 25988247 )
2015
44
Protective effect of casein phosphopeptide-amorphous calcium phosphate on enamel erosion: Atomic force microscopy studies. ( 25917931 )
2015
45
In vitro effect of calcium-containing prescription-strength fluoride toothpastes on bovine enamel erosion under hyposalivation-simulating conditions. ( 25864237 )
2015
46
Protective effect of fluoride varnish and fluoride gel on enamel erosion: roughness, SEM-EDS, and µ-EDXRF studies. ( 25626779 )
2015
47
In Vitro Effects of Resin Infiltration on Enamel Erosion Inhibition. ( 25587972 )
2015
48
Fluoride varnishes containing calcium glycerophosphate: fluoride uptake and the effect on in vitro enamel erosion. ( 25416637 )
2015
49
Er:YAG laser irradiation to control the progression of enamel erosion: an in situ study. ( 24985348 )
2015
50
Effect of pretreatment with an Er:YAG laser and fluoride on the prevention of dental enamel erosion. ( 24149579 )
2015

Variations for Enamel Erosion

Expression for Enamel Erosion

Search GEO for disease gene expression data for Enamel Erosion.

Pathways for Enamel Erosion

Pathways related to Enamel Erosion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.87 SMARCA2 SMARCA4
2
Show member pathways
10.47 SMARCA2 SMARCA4

GO Terms for Enamel Erosion

Cellular components related to Enamel Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SWI/SNF complex GO:0016514 9.16 SMARCA2 SMARCA4
2 nBAF complex GO:0071565 8.96 SMARCA2 SMARCA4
3 npBAF complex GO:0071564 8.62 SMARCA2 SMARCA4

Biological processes related to Enamel Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.5 MTF1 SMARCA2 SMARCA4
2 negative regulation of cell growth GO:0030308 9.26 SMARCA2 SMARCA4
3 chromatin remodeling GO:0006338 9.16 SMARCA2 SMARCA4
4 ATP-dependent chromatin remodeling GO:0043044 8.96 SMARCA4 SMARCA2
5 response to cadmium ion GO:0046686 8.62 MTF1 GPI

Molecular functions related to Enamel Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 histone binding GO:0042393 9.26 SMARCA2 SMARCA4
2 DNA-dependent ATPase activity GO:0008094 9.16 SMARCA2 SMARCA4
3 transcription coactivator activity GO:0003713 9.13 MTF1 SMARCA2 SMARCA4
4 hydrolase activity, acting on acid anhydrides GO:0016817 8.62 SMARCA2 SMARCA4

Sources for Enamel Erosion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....