MCID: ENM002
MIFTS: 25

Enamel Erosion

Categories: Oral diseases

Aliases & Classifications for Enamel Erosion

MalaCards integrated aliases for Enamel Erosion:

Name: Enamel Erosion 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:2497
ICD9CM 34 521.31
UMLS 70 C1456161

Summaries for Enamel Erosion

MalaCards based summary : Enamel Erosion is related to tooth erosion and root caries. An important gene associated with Enamel Erosion is SHF (Src Homology 2 Domain Containing F), and among its related pathways/superpathways is Nitrogen metabolism. The drugs sodium fluoride and Anti-Infective Agents, Local have been mentioned in the context of this disorder. Affiliated tissues include tongue.

Related Diseases for Enamel Erosion

Graphical network of the top 20 diseases related to Enamel Erosion:



Diseases related to Enamel Erosion

Symptoms & Phenotypes for Enamel Erosion

Drugs & Therapeutics for Enamel Erosion

Drugs for Enamel Erosion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
sodium fluoride Approved Phase 3 7681-49-4
2 Anti-Infective Agents, Local Phase 3
3 Listerine Phase 3
4 Protective Agents Phase 3
5 Fluorides Phase 3
6 Anti-Infective Agents Phase 3
7 Fluorophosphate
8 Tin Fluorides
9
Arginine Investigational, Nutraceutical 74-79-3 6322

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect of Fluoride in an Experimental Dentifrice on Remineralization of Erosive Lesions In-Situ Completed NCT01641237 Phase 3 sodium fluoride;no added fluoride in a silica base
2 Evaluation of a Test Mouthwash and Dentifrice Regimen in an In-situ Model of Dental Erosion Completed NCT01128972 Phase 2 Sodium fluoride;Sodium monoflurophosphate;Sterile water
3 Preliminary Clinical Study of Ultrasound to Measure Enamel Thickness Completed NCT01622920 Phase 1
4 Bioavailable Stannous Fluoride Dentifrice Meta-Analyses: Effects on Dentine Hypersensitivity and Enamel Erosion Completed NCT04006470 Stannous fluoride dentifrice;Positive control dentifrice;Negative control dentifrice
5 Study to Investigate the Initial Stages of Enamel Erosion in Vivo Completed NCT02533466
6 Bioavailable Stannous Fluoride Dentifrice Meta-Analyses: Effects on Dentine Hypersensitivity and Enamel Erosion Completed NCT04005417 Stannous fluoride dentifrice;Positive control dentifrice;Negative control dentifrice

Search NIH Clinical Center for Enamel Erosion

Genetic Tests for Enamel Erosion

Anatomical Context for Enamel Erosion

MalaCards organs/tissues related to Enamel Erosion:

40
Tongue

Publications for Enamel Erosion

Articles related to Enamel Erosion:

(show top 50) (show all 360)
# Title Authors PMID Year
1
Impact of mucin on the anti-erosive/anti-abrasive efficacy of chitosan and/or F/Sn in enamel in vitro. 61
33674643 2021
2
Analysis of laboratory adhesion studies in eroded enamel and dentin: a scoping review. 61
33629074 2021
3
Bioavailable gluconate chelated stannous fluoride toothpaste meta-analyses: Effects on dentine hypersensitivity and enamel erosion. 61
33383100 2021
4
Salivary pellicle modification with polyphenol-rich teas and natural extracts to improve protection against dental erosion. 61
33387569 2021
5
Impact of early biofilm on the assessment of initial enamel erosion with swept-source optical coherence tomography. 61
33491383 2021
6
Effect of titanium tetrafluoride/sodium fluoride solutions containing chitosan at different viscosities on the protection of enamel erosion in vitro. 61
33045615 2020
7
Protective effect of fluorides on erosion and erosion/abrasion in enamel: a systematic review and meta-analysis of randomized in situ trials. 61
33113459 2020
8
Measurement of erosion depth using microcomputed tomography and light microscopy. 61
32681812 2020
9
Nanoencapsulated fluoride as a remineralization option for dental erosion: an in vitro study. 61
33245686 2020
10
Statherin-derived peptide protects against intrinsic erosion. 61
32919104 2020
11
Enamel Erosion: A Possible Preventive Approach by Casein Phosphopeptide Amorphous Calcium Phosphate-An In Vitro Study. 61
33623334 2020
12
Evaluation of the remineralisation potential of bioactive glass, nanohydroxyapatite and casein phosphopeptide-amorphous calcium phosphate fluoride-based toothpastes on enamel erosion lesion -An Ex Vivo study. 61
33433502 2020
13
Effect of the usage of Er,Cr:YSGG laser with and without different remineralization agents on the enamel erosion of primary teeth. 61
32472426 2020
14
Stannous Fluoride Preventive Effect on Enamel Erosion: An In Vitro Study. 61
32858829 2020
15
Efficacy of silver diamine fluoride and sodium fluoride in inhibiting enamel erosion: an ex vivo study with primary teeth. 61
32860201 2020
16
The effect of CO2 9.3 μm short-pulsed laser irradiation in enamel erosion reduction with and without fluoride applications-a randomized, controlled in vitro study. 61
32030555 2020
17
Site-Specific Profiling of the Dental Mycobiome Reveals Strong Taxonomic Shifts during Progression of Early-Childhood Caries. 61
31953340 2020
18
Salivary Hemoglobin Protects against Erosive Tooth Wear in Gastric Reflux Patients. 61
33171464 2020
19
Chapter 4: Microelements: Part I: Zn, Sn, Cu, Fe and I. 61
31940644 2020
20
Effect of different citrus sweets on the development of enamel erosion in vitro. 61
32813839 2020
21
Quantitative and Qualitative Evaluation of Enamel Erosion Following Air Abrasion with Bioactive Glass 45S5. 61
32515424 2020
22
Enamel surface loss after erosive and abrasive cycling with different periods of immersion in human saliva. 61
31541844 2020
23
Erosive effect of milk, honey, cereal porridge, and millet porridge on enamel of primary teeth: An in vitro study. 61
32246695 2020
24
Viscosity of chitosan impacts the efficacy of F/Sn containing toothpastes against erosive/abrasive wear in enamel. 61
31743693 2020
25
The Addition of Propylene Glycol Alginate to a Fluoride Solution to Control Enamel Wear: An in situ Study. 61
33176315 2020
26
Randomised study of the effects of fluoride and time on in situ remineralisation of acid-softened enamel. 61
30997568 2019
27
Remineralizing Effect of Casein Phosphopeptide-Amorphous Calcium Phosphate and Sodium Fluoride on Artificial Tooth Enamel Erosion: An In Vitro Study. 61
31892675 2019
28
Adverse effects of respiratory disease medicaments and tooth brushing on teeth: A scanning electron microscopy, X-ray fluorescence and infrared spectroscopy study. 61
31150562 2019
29
Randomized in situ clinical trial evaluating erosion protection efficacy of a 0.454% stannous fluoride dentifrice. 61
30556372 2019
30
Highly acidic pH values of carbonated sweet drinks, fruit juices, mineral waters and unregulated fluoride levels in oral care products and drinks in India: a public health concern. 61
30015577 2019
31
The erosion protection efficacy of a stabilized stannous fluoride dentifrice: An in situ randomized clinical trial. 61
31295395 2019
32
Randomized in situ study on the efficacy of CO2 laser irradiation in increasing enamel erosion resistance. 61
30267277 2019
33
Effect of Er,Cr:YSGG on Remineralization Using CPP - ACPF (MI - Paste Plus) after Enamel Erosion Caused by Carbonated Soft Drink in Primary Teeth: In-Vitro Study. 61
31049105 2019
34
Effect of Er,Cr:YSGG laser associated with fluoride on the control of enamel erosion progression. 61
30690411 2019
35
Effect of different protective agents on enamel erosion: An in vitro investigation. 61
30805114 2019
36
Impact of surface micromorphology and demineralization severity on enamel loss measurements by cross-polarization optical coherence tomography. 61
30582963 2019
37
Effect of CPP-ACPF and Nano-hydroxyapatite Preventive Treatments on the Susceptibility of Enamel to Erosive Challenge. 61
31204397 2019
38
Direct radiation-induced effects on dental hard tissue. 61
30635005 2019
39
Influence of cigarette smoke combined with different toothpastes on enamel erosion. 61
31800865 2019
40
Influence of Surfactants and Fluoride against Enamel Erosion. 61
29874648 2019
41
Dental Problems in Primary Care. 61
30485039 2018
42
Towards quantitative analysis of enamel erosion by focused ion beam tomography. 61
30301623 2018
43
Comparative evaluation of grape seed and cranberry extracts in preventing enamel erosion: An optical emission spectrometric analysis. 61
30294113 2018
44
In situ monitoring and analysis of enamel demineralisation using synchrotron X-ray scattering. 61
30026103 2018
45
In situ effect of Tooth Mousse containing CPP-ACP on human enamel subjected to in vivo acid attacks. 61
29857075 2018
46
Anti-erosive effect of calcium carbonate suspensions. 61
30305876 2018
47
Dental and oropharyngeal lesions in rats with chronic acid reflux esophagitis. 61
28882408 2018
48
An in vitro study on the influence of viscosity and frequency of application of fluoride/tin solutions on the progression of erosion of bovine enamel. 61
29425811 2018
49
Temperature-dependent erosivity of drinks in a model simulating oral fluid dynamics. 61
29366671 2018
50
Fluoride toothpastes containing micrometric or nano-sized sodium trimetaphosphate reduce enamel erosion in vitro. 61
29037096 2018

Variations for Enamel Erosion

Expression for Enamel Erosion

Search GEO for disease gene expression data for Enamel Erosion.

Pathways for Enamel Erosion

Pathways related to Enamel Erosion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.09 CA8 CA6

GO Terms for Enamel Erosion

Biological processes related to Enamel Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol phosphorylation GO:0046854 9.16 TTC7A TMEM150A
2 one-carbon metabolic process GO:0006730 8.96 CA8 CA6
3 biomineral tissue development GO:0031214 8.62 STATH AMELX

Molecular functions related to Enamel Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydro-lyase activity GO:0016836 9.26 CA8 CA6
2 carbonate dehydratase activity GO:0004089 9.16 CA8 CA6
3 structural constituent of tooth enamel GO:0030345 8.96 STATH AMELX
4 hydroxyapatite binding GO:0046848 8.62 STATH AMELX

Sources for Enamel Erosion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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