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MCID: ENC004
MIFTS: 66

Encephalitis

Categories: Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Encephalitis

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MalaCards integrated aliases for Encephalitis:

Name: Encephalitis 12 77 55 30 56 6 44 45 15 74

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
Anatomical: Neuronal diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:9588
MeSH 45 D004660
NCIt 51 C26760
SNOMED-CT 69 45170000
ICD10 34 G04.9
UMLS 74 C0014038
Sources

Summaries for Encephalitis

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NINDS : 55 Meningitis is an infection of the meninges, the membranes that surround the brain and spinal cord. Encephalitis is inflammation of the brain itself. Anyone can get encephalitis or meningitis. Causes of encephalitis and meningitis include viruses, bacteria, fungus, and parasites. Anyone experiencing symptoms of meningitis or encephalitis should see a doctor immediately. Symptoms of encephalitis that might require emergency treatment include loss of consciousness, seizures, muscle weakness, or sudden severe dementia. Other symptoms include: sudden fever, headache, vomiting, heightened sensitivity to light, stiff neck and back, confusion and impaired judgment, drowsiness, weak muscles, a clumsy and unsteady gait, irritability. In more severe cases, people may have problems with speech or hearing, vision problems, and hallucinations. Symptoms of meningitis, which may appear suddenly, often include: high fever, severe and persistent headache, stiff neck, nausea, sensitivity to bright light, vomiting, and changes in behavior such as confusion, sleepiness, and difficulty waking up. In infants, symptoms of meningitis or encephalitis may include fever, vomiting, lethargy, body stiffness, unexplained irritability, and a full or bulging fontanel (the soft spot on the top of the head).

MalaCards based summary : Encephalitis is related to tick-borne encephalitis and herpes simplex encephalitis, and has symptoms including seizures, tremor and back pain. An important gene associated with Encephalitis is UNC93B1 (Unc-93 Homolog B1, TLR Signaling Regulator), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Prednisone and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and testes, and related phenotypes are no effect and Upregulation of RLR pathway after Sendai virus (SeV) infection

Disease Ontology : 12 A brain disease that is characterized as an acute inflammation of the brain with flu-like symptoms.

MedlinePlus : 44 Encephalitis is an inflammation of the brain. Usually the cause is a viral infection, but bacteria can also cause it. It can be mild or severe. Most cases are mild. You may have flu-like symptoms. With a mild case, you may just need rest, plenty of fluids, and a pain reliever. Severe cases need immediate treatment. Symptoms of severe cases include Severe headache Sudden fever Drowsiness Vomiting Confusion Seizures In babies, additional symptoms may include constant crying, poor feeding, body stiffness, and bulging in the soft spots of the skull. Severe cases may require a stay in the hospital. Treatments include oral and intravenous (IV) medicines to reduce inflammation and treat infection. Patients with breathing difficulties may need artificial respiration. Some people may need physical, speech, and occupational therapy once the illness is under control. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 77 Encephalitis is inflammation of the brain. Severity is variable. Symptoms may include headache, fever,... more...

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Related Diseases for Encephalitis

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Diseases in the Encephalitis family:

Viral Encephalitis Autoimmune Encephalitis

Diseases related to Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 814)
# Related Disease Score Top Affiliating Genes
1 tick-borne encephalitis 34.4 CCR5 CD209 CXCL10 TLR3
2 herpes simplex encephalitis 34.2 IRF3 TICAM1 TLR3 TRAF3 UNC93B1
3 japanese encephalitis 33.9 CCL5 CD209 CLEC4G CLEC4M CXCL10 DDX58
4 viral encephalitis 33.9 CCL2 CCL5 CXCL10 IL1B
5 west nile virus 32.6 CCR5 CD209 CLEC4M DDX58 IRF3 RSAD2
6 malaria 31.5 CCL2 CCL5 CXCL10 CXCL9 IL1B
7 herpes simplex 31.5 CD209 DDX58 IRF3 TICAM1 TLR3 TRAF3
8 dengue virus 30.9 CD209 DDX58 RPSA RSAD2
9 measles 30.9 CD209 DDX58 TLR3
10 rabies 30.8 CCL5 CXCL10 IRF3 TLR3
11 noonan syndrome 3 30.8 DDX58 IRF3 RSAD2 TLR3
12 yellow fever 30.6 CCL2 CCL5 CCR5 RSAD2
13 mouth disease 30.5 IL1B IRF3 TLR3
14 influenza 30.5 CCL5 DDX58 IRF3 RSAD2 TLR3 XPO1
15 viral meningitis 30.4 CCL2 CCL5 CXCL10
16 stomatitis 30.4 DDX58 IL1B RSAD2
17 neuritis 30.4 CCL2 CCL5 CXCL10 IL1B
18 chikungunya 30.3 CCL2 CCL5 DDX58 IL1B RSAD2
19 opsoclonus-myoclonus syndrome 30.2 CXCL10 CXCL9
20 pneumonia 30.2 CCL2 CCL5 IL1B
21 trypanosomiasis 30.1 CCL2 CCL5 IL1B
22 lymphadenitis 30.0 CD209 CXCL9 IL1B
23 demyelinating disease 30.0 CCL2 CCL5 CXCL10 IL1B
24 cerebral hemorrhage 30.0 GFAP IL1B
25 multiple sclerosis 29.9 CCL2 CCL5 CCR5 CXCL10 GFAP IL1B
26 cytomegalovirus infection 29.8 CCL2 CCL5 IL1B IRF3
27 hepatitis c 29.8 CLEC4M CXCL10 DDX58 IRF3 TLR3
28 human immunodeficiency virus type 1 29.6 CCL2 CCL5 CCR5 CD209 CLEC4M CXCL10
29 hepatitis c virus 29.6 CCR5 CLEC4M DDX58 IRF3 RSAD2
30 pulmonary sarcoidosis 29.5 CCL2 CCL5 CCR5
31 chagas disease 29.4 CCL2 CCR5 IL1B
32 central nervous system disease 29.2 CCL2 CCR5 GFAP IL1B
33 severe acute respiratory syndrome 29.1 CCL2 CCL5 CD209 CLEC4M CXCL10 IRF3
34 viral infectious disease 29.1 CCL5 CCR5 CD209 CXCL10 DDX58 IL1B
35 la crosse encephalitis 12.7
36 st. louis encephalitis 12.6
37 eastern equine encephalitis 12.6
38 limbic encephalitis 12.5
39 rasmussen encephalitis 12.5
40 western equine encephalitis 12.5
41 murray valley encephalitis 12.5
42 granulomatous amebic encephalitis 12.5
43 west nile encephalitis 12.5
44 autoimmune encephalitis 12.4
45 venezuelan equine encephalitis 12.4
46 meningitis and encephalitis 12.4
47 limbic encephalitis with lgi1 antibodies 12.4
48 hhv-6 encephalitis 12.4
49 bickerstaff brainstem encephalitis 12.3
50 encephalitis/encephalopathy, mild, with reversible myelin vacuolization 12.3

Graphical network of the top 20 diseases related to Encephalitis:



Diseases related to Encephalitis
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Symptoms & Phenotypes for Encephalitis

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UMLS symptoms related to Encephalitis:


seizures, tremor, back pain, pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness

GenomeRNAi Phenotypes related to Encephalitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.26 CCL2 CCL5 CCR5 CD209 CLEC4G CLEC4M
2 Upregulation of RLR pathway after Sendai virus (SeV) infection GR00302-A 8.92 DDX58 IRF3 RPSA XPO1

MGI Mouse Phenotypes related to Encephalitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 CCL5 CCR5 CLEC4G CLEC4M CXCL10 DDX58
2 homeostasis/metabolism MP:0005376 9.97 CCR5 CLEC4G CLEC4M CXCL10 DDX58 GFAP
3 immune system MP:0005387 9.83 CCL2 CCL5 CCR5 CLEC4G CLEC4M CXCL10
4 mortality/aging MP:0010768 9.4 CCR5 CLEC4M CXCL10 DDX58 GFAP IL1B
Sources

Drugs & Therapeutics for Encephalitis

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Drugs for Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 273)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Azithromycin Approved Phase 4,Phase 1 83905-01-5 447043 55185
3
leucovorin Approved Phase 4,Phase 2,Phase 1,Not Applicable 58-05-9 143 6006
4
Pyrimethamine Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 58-14-0 4993
5
Sulfamethoxazole Approved Phase 4 723-46-6 5329
6
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
7
Sulfadiazine Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 68-35-9 5215
8
Formaldehyde Approved, Vet_approved Phase 4,Phase 3 50-00-0 712
9
Ethanol Approved Phase 4,Not Applicable 64-17-5 702
10
Minocycline Approved, Investigational Phase 4,Phase 3,Phase 1 10118-90-8 5281021
11
Dimenhydrinate Approved Phase 4 523-87-5 441281
12
Natalizumab Approved, Investigational Phase 4 189261-10-7
13
Tenofovir Approved, Experimental, Investigational Phase 4,Phase 2 147127-20-6 464205
14
Emtricitabine Approved, Investigational Phase 4,Phase 2 143491-57-0 60877
15
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 83-43-2 6741
16
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Not Applicable 302-25-0
17
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Not Applicable 2921-57-5
18
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 50-24-8 5755
19
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
20
Racepinephrine Approved Phase 4 329-65-7 838
21
Lamivudine Approved, Investigational Phase 4,Phase 2 134678-17-4 60825
22
Cobicistat Approved Phase 4 1004316-88-4
23
Dolutegravir Approved Phase 4 1051375-16-6 54726191
24
Abacavir Approved, Investigational Phase 4 136470-78-5 441300 65140
25
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 59-30-3 6037
26
Lactitol Investigational Phase 4,Phase 3,Phase 2 585-88-6, 585-86-4 493591
27
Prednisolone hemisuccinate Experimental Phase 4,Phase 2,Not Applicable 2920-86-7
28 Immunologic Factors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
29 Vaccines Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
30 Immunoglobulins Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
31 Antibodies Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
32 Epoetin alfa Phase 4 113427-24-0
33 Hematinics Phase 4
34 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
35 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
36 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
38 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
39 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable
40 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Anti-Retroviral Agents Phase 4,Phase 1,Phase 2,Not Applicable
42 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Anti-HIV Agents Phase 4,Phase 1,Phase 2,Not Applicable
44 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Antibodies, Blocking Phase 4,Phase 3,Phase 2
46 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1,Phase 2
47 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Vitamin B9 Phase 4,Phase 2,Phase 1,Not Applicable
49 Vitamin B Complex Phase 4,Phase 2,Phase 1,Not Applicable
50 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 341)
# Name Status NCT ID Phase Drugs
1 Antibody Response of a Boosted Japanese Encephalitis Chimeric Virus Vaccine (JE-CV) in Children Unknown status NCT01954810 Phase 4
2 Effect of Erythropoietin in Refractory Autoimmune Encephalitis Patients Unknown status NCT03004209 Phase 4 Erythropoietin
3 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
4 Immunogenicity of a Live Attenuated Chimeric JE Vaccine (IMOJEV) as a Booster Dose in Thai Children Primed With CD.JEVAX Completed NCT02526550 Phase 4
5 A Prospective, Open Label Study of Human T Cell Responses to Live Attenuated Japanese Encephalitis Vaccine SA14-14-2 Completed NCT01656200 Phase 4
6 Long-term Immunogenicity and Safety of Fourth Administration of Boryung Cell-Culture Japanese Encephalitis Vaccineinj Completed NCT02532569 Phase 4
7 Live Attenuated Japanese Encephalitis (JE) Vaccine Coadministered With Measles Vaccine in Infants 9 Months of Age Completed NCT00463684 Phase 4
8 Immunogenicity of Co-administration of Measles and Japanese Encephalitis Vaccines Completed NCT02643433 Phase 4
9 Lot-to-lot Consistency Trial of Japanese Encephalitis Live Attenuated SA 14-14-2 Vaccine Completed NCT01567865 Phase 4
10 Study to Evaluate Long Term Immunogenicity up to 10 Years After the First Booster Immunization With Tick Borne Encephalitis Vaccine in Adults Who Received 1 of 3 Different Primary Vaccination Schedules Completed NCT01562444 Phase 4
11 6-year Antibody Check After Third Vaccination Against Japanese Encephalitis Completed NCT02039440 Phase 4
12 Immunogenicity and Safety of Japanese Encephalitis Vaccine When Given With Measles-Mumps-Rubella Vaccine Completed NCT02880865 Phase 4
13 TBE Antibody Persistence and Booster Vaccination Study in Children and Adolescents (Follow-up to Study 209) Completed NCT00161967 Phase 4
14 An Extension Study to Determine the Persistence of Tick-borne Encephalitis (TBE)-Specific Antibody Responses Among Children and Adolescents Previously Immunized Against TBE Completed NCT01106482 Phase 4
15 Tick-Borne Encephalitis (TBE) Seropersistence After First Booster and Response to a Second Booster in Children, Adolescents and Young Adults (Follow-Up to Study 700401) Completed NCT00894686 Phase 4
16 Long-term Immunogenicity After Receipt of JE Vaccine and Antibody Response and Safety to a Booster Dose Completed NCT02514746 Phase 4
17 Cellular and Humoral Immunity in Elderly After Immunization With a Japanese Encephalitis Vaccine Completed NCT01398540 Phase 4
18 This is a Study to Assess the Safety and Immunogenicity of Ixiaro® (IC51) in an Elderly Population Completed NCT01158599 Phase 4
19 TBE Antibody Persistence and Booster Vaccination Study in Adults (Follow-up to Study 223) Completed NCT00503529 Phase 4
20 Cervicovaginal Immune Responses to 3 Deltoid or Thigh Intramuscular (IM) TicoVac Completed NCT01710189 Phase 4 TicoVac
21 Treatment of Cerebral Toxoplasmosis in HIV/AIDS Completed NCT00367081 Phase 4 TMX-SMX (Bactrim(R));Pyrimethamine plus Sulfadiazine plus leucoverin
22 Immunogenicity and Safety Study of a Rapid Immunization Schedule With FSME-IMMUN 0.5 mL in Healthy Adults Aged 16 - 65 Years Completed NCT00161954 Phase 4
23 Post-licensure Safety Study of IMOJEV® in Thailand Completed NCT01981967 Phase 4
24 Humoral and Cellular Immunity of Low and High-responders After Tick-borne Encephalitis Vaccination Completed NCT00804219 Phase 4
25 Evaluation of Long-Term Immunogenicity in Subjects Boosted With a TBE Vaccine for Adults Completed NCT00311493 Phase 4
26 Study of the Safety, Tolerability and Immune Response of TBE Vaccines Administered to Healthy Children Completed NCT00311441 Phase 4
27 TBE Seropersistence up to 10 Years After First Booster in Adults Completed NCT01582698 Phase 4
28 Immunogenicity and Safety Study of a Third Vaccination With FSME-IMMUN 0.5 mL in Subjects Previously Vaccinated According to a Rapid Immunization Schedule (Follow-up to Study 225) Completed NCT00163540 Phase 4
29 Safety and Long-term Evaluation (up to 5 Years) of First Booster Immunization With Novartis' TBE Vaccine for Adults in Adolescents and Adults Completed NCT00387634 Phase 4
30 Influence of Persistent CMV-infection on Immune Senescence Completed NCT00461695 Phase 4
31 Evaluation of Long-Term Immunogenicity in Children and Adolescents Boosted With a New Pediatric TBE Vaccine After Five Years Completed NCT00452621 Phase 4
32 Immunogenicity of SA 14-14-2 JE Vaccine Completed NCT01635816 Phase 4
33 Investigation of the Seropersistence of TBE Antibodies and the Booster Response to FSME-IMMUN 0.5 ml in Adults Aged 18 - 67 Years Completed NCT00161785 Phase 4
34 Immunogenicity and Safety of Live Attenuated Varicella Vaccine Combined With Live Attenuated JE Vaccine Completed NCT01815073 Phase 4
35 Comparison of Vaccination Routes: Subcutaneous Versus Intramuscular Application of FSME-Immun® Completed NCT02511587 Phase 4
36 Immediate Versus Deferred Antiretroviral Therapy in HIV-infected Patients Presenting With Acute AIDS-defining Events Completed NCT01417949 Phase 4
37 Study of Evaluating Safety and Immunogenicity of 23-Valent Pneumococcal Polysaccharide Vaccine With Influenza Vaccine in Children and Adults Completed NCT02062281 Phase 4
38 Minocycline to Treat Childhood Regressive Autism Completed NCT00409747 Phase 4 Minocycline
39 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Completed NCT03226119 Phase 4
40 TBE Vaccination in Allergic Patients Completed NCT02511535 Phase 4
41 A Study of Fluzone® High-Dose Vaccine Compared With Fluzone® Vaccine In Elderly Adults Completed NCT01427309 Phase 4
42 SOLFAMU Study of Nasal Brushing Collected OLFActory MUcosa Samples in the Diagnosis of Human Encephalopathies Recruiting NCT02951559 Phase 4
43 Clinical Study on Combined Immune Effect of EV71 Inactivated Vaccine Recruiting NCT03519568 Phase 4
44 The Aim of This Study is to Investigate the Persistence of Antibody Response in Adults up to 15 Years After One Booster Dose of GlaxoSmithKline (GSK) Biologicals' Encepur Adults Vaccine Active, not recruiting NCT03294135 Phase 4
45 Safety and Effectiveness of Switching Relapsing MS Patients Treated With Natalizumab at Risk for PML to Teriflunomide Active, not recruiting NCT01970410 Phase 4 teriflunomide
46 A Phase IV, Open-label, Randomised, Pilot Clinical Trial Designed to Evaluate the Potential Neurotoxicity of Dolutegravir/Lamivudine/Abacavir in Neurosymptomatic HIV Patients and Its Reversibility After Switching to Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide. DREAM Study Active, not recruiting NCT03067285 Phase 4 ELV/COBI/FTC/TAF;DTG/3TC/ABC + ELV/COBI/FTC/TAF
47 The Phase IVd of Inactivated Enterovirus 71 Vaccine Enrolling by invitation NCT03296410 Phase 4
48 IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis Terminated NCT00774631 Phase 4
49 Corticosteroids for Immune Reconstitution Inflammatory Syndrome (IRIS) Terminated NCT01211665 Phase 4 Methylprednisolone;Prednisolone
50 A Study to Evaluate the One Year Long-term Persistence of Immune Responses Following Two Different Rabies Vaccine Post-exposure Regimens in Chinese Children Withdrawn NCT03192371 Phase 4

Search NIH Clinical Center for Encephalitis

Cochrane evidence based reviews: encephalitis

Sources

Genetic Tests for Encephalitis

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Genetic tests related to Encephalitis:

# Genetic test Affiliating Genes
1 Encephalitis 30
Sources

Anatomical Context for Encephalitis

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MalaCards organs/tissues related to Encephalitis:

42
Brain, T Cells, Testes, Lung, Kidney, B Cells, Spinal Cord
Sources

Publications for Encephalitis

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Articles related to Encephalitis:

(show top 50) (show all 11963)
# Title Authors Year
1
An overlapping case of Bickerstaff brainstem encephalitis and acute motor axonal neuropathy variant of Guillain-Barré syndrome associated with systemic lupus erythematosus. ( 30444497 )
2019
2
Leucine-Rich Glioma-Inactivated Protein 1 Antibody-Positive Limbic Encephalitis in a Patient with Adenocarcinoma of Prostate: A Case Report. ( 30692776 )
2019
3
Anti-N-Methyl-D-Aspartate Receptor Encephalitis in a Patient With Antithyroid Peroxidase Antibodies and a Parotid Pleomorphic Adenoma. ( 30983904 )
2019
4
Transient Dyschromatopsia, Static Form Agnosia, and Prosopagnosia Observed in a Patient with Anti-NMDA Receptor Encephalitis. ( 31061739 )
2019
5
Anti-Amphiphysin-associated limbic encephalitis in a 72-year-old patient with aortic angiosarcoma. ( 30872337 )
2019
6
Diagnostic response to a cross-border challenge for the Swiss caprine arthritis encephalitis virus eradication program. ( 30696612 )
2019
7
Serological Evidence of Tick-Borne Encephalitis and West Nile Virus Infections Among Children with Arthritis in Turkey. ( 30688547 )
2019
8
Autoimmune Encephalitis as an Extra-articular Manifestation of Rheumatoid Arthritis. ( 30449780 )
2019
9
Psychosis of dual origin in HIV infection: Viral escape syndrome and autoimmune encephalitis. ( 31041138 )
2019
10
Grading the severity of autoimmune encephalitis: advances and pitfalls. ( 31049995 )
2019
11
Reply to "Grading the severity of autoimmune encephalitis: advances and pitfalls". ( 31050012 )
2019
12
Heidenhain variant sporadic Creutzfeldt-Jakob disease diagnosed as an autoimmune encephalitis due to a false-positive GAD autoantibody. ( 31061195 )
2019
13
Autoimmune encephalitis with anti-IgLON5 and anti-GABAB-receptor antibodies: A case report. ( 31096519 )
2019
14
Efficacy of subcutaneous immunoglobulin therapy in a patient with autoimmune encephalitis: a case report. ( 30232671 )
2019
15
Admission diagnoses of patients later diagnosed with autoimmune encephalitis. ( 30421340 )
2019
16
Proportion and spectrum of movement disorders in adolescent and adult patients of autoimmune encephalitis of non-neoplastic aetiology. ( 30455136 )
2019
17
Ictal piloerection is associated with high-grade glioma and autoimmune encephalitis-Results from a systematic review. ( 30497014 )
2019
18
Management and prognostic markers in patients with autoimmune encephalitis requiring ICU treatment. ( 30568992 )
2019
19
Prognosticating autoimmune encephalitis: A systematic review. ( 30595145 )
2019
20
Autoimmune encephalitis: A costly condition. ( 30674590 )
2019
21
Development of the clinical assessment scale in autoimmune encephalitis. ( 30675918 )
2019
22
Diagnosing autoimmune encephalitis based on clinical features and autoantibody findings. ( 30676128 )
2019
23
Pembrolizumab-induced autoimmune encephalitis in a patient with advanced non-small cell lung cancer: A case report. ( 30680206 )
2019
24
Antibody-LGI 1 autoimmune encephalitis manifesting as rapidly progressive dementia and hyponatremia: a case report and literature review. ( 30732585 )
2019
25
Sleep disturbances are common in patients with autoimmune encephalitis. ( 30741377 )
2019
26
Autoimmune Encephalitis Secondary to Melanoma. ( 30743260 )
2019
27
Fulminant Subacute Sclerosing Panencephalitis Mimicking Autoimmune Encephalitis. ( 30762710 )
2019
28
A transdiagnostic pattern of psychiatric symptoms in autoimmune encephalitis. ( 30765327 )
2019
29
A Rasmussen encephalitis, autoimmune encephalitis, and mitochondrial disease mimicker: expanding the DNM1L-associated intractable epilepsy and encephalopathy phenotype. ( 30767894 )
2019
30
A clinical TRIAD for early suspicion of autoimmune encephalitis as a possibility in patients presenting with progressive cognitive decline. ( 30836326 )
2019
31
Editorial: Emerging Challenges in the Diagnosis and Treatment of Autoimmune Encephalitis. ( 30858821 )
2019
32
Autoimmune encephalitis: frequency and prognosis. ( 30877379 )
2019
33
Immune-Checkpoint-Inhibitor-Induced Severe Autoimmune Encephalitis Treated by Steroid and Intravenous Immunoglobulin. ( 30877699 )
2019
34
An Assay to Determine Mechanisms of Rapid Autoantibody-Induced Neurotransmitter Receptor Endocytosis and Vesicular Trafficking in Autoimmune Encephalitis. ( 30881339 )
2019
35
Atypical Autoimmune Encephalitis With Neuropil Antibodies Against a Yet Unknown Epitope. ( 30891000 )
2019
36
Commentary: Detection Methods for Autoantibodies in Suspected Autoimmune Encephalitis. ( 30915021 )
2019
37
Epilepsy Emergencies: Status Epilepticus, Acute Repetitive Seizures, and Autoimmune Encephalitis. ( 30921018 )
2019
38
In vitro neuronal network activity as a new functional diagnostic system to detect effects of Cerebrospinal fluid from autoimmune encephalitis patients. ( 30944364 )
2019
39
Clinical characteristics and factors associated with short-term prognosis in adult patients with autoimmune encephalitis of non-neoplastic etiology. ( 30955116 )
2019
40
Recognizing autoimmune encephalitis as a cause of seizures: Treating cause and not effect. ( 30979858 )
2019
41
Editorial: Recent Advances in Psychiatry From Psycho-Neuro-Immunology Research: Autoimmune Encephalitis, Autoimmune Encephalopathy, and Mild Encephalitis. ( 31001151 )
2019
42
Clinical Presentation and Outcome in Autoimmune Encephalitis Associated With N-Type Voltage-Gated Calcium Channels in Children. ( 31014180 )
2019
43
Balint syndrome in anti-NMDA receptor encephalitis. ( 30588484 )
2019
44
Bickerstaff Brainstem Encephalitis and overlapping Guillain-Barré syndrome in children: Report of two cases and review of the literature. ( 30502045 )
2019
45
Long-term Sequelae of Pediatric Bickerstaff Brainstem Encephalitis Includes Autonomic and Sleep Dysregulation. ( 30604651 )
2019
46
A rapidly fatal case of anti-NMDA receptor encephalitis due to acute brain edema and herniation. ( 31019100 )
2019
47
Fulminant thymomatous AMPAR-antibody limbic encephalitis with hypertonic coma, bruxism, an isoelectric electroencephalogram and temporal cortical atrophy, with recovery. ( 30796080 )
2019
48
Transient splenial hyperintensity in a rare case of chikungunya encephalitis. ( 30860134 )
2019
49
An infection cocktail: malaria, dengue, chikungunya and Japanese encephalitis. ( 30259796 )
2019
50
Deleted in colorectal cancer (netrin-1 receptor) antibodies and limbic encephalitis in a cat with hippocampal necrosis. ( 30942925 )
2019
Sources

Variations for Encephalitis

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ClinVar genetic disease variations for Encephalitis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ABCD1 NM_000033.3(ABCD1): c.1866-1G> C single nucleotide variant Likely pathogenic rs1557055311 GRCh37 Chromosome X, 153008674: 153008674
2 ABCD1 NM_000033.3(ABCD1): c.1866-1G> C single nucleotide variant Likely pathogenic rs1557055311 GRCh38 Chromosome X, 153743220: 153743220
Sources

Expression for Encephalitis

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Search GEO for disease gene expression data for Encephalitis.
Sources

Pathways for Encephalitis

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Pathways related to Encephalitis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.92 CCL2 CCL5 CCR5 CD209 CXCL10 DDX58
2
Akt Signaling 65
Show member pathways
 13.31 CCL2 CCL5 CCR5 CXCL10 CXCL9 IL1B
3
Cytokine Signaling in Immune system 67
Show member pathways
 13.24 CCL2 CCL5 CCR5 CXCL10 DDX58 IL1B
4
Toll-like Receptor Signaling Pathway 1 38
Show member pathways
 12.85 CCL2 CCL5 CXCL10 CXCL9 IL1B IRF3
5
CCR5 Pathway in Macrophages 65
Show member pathways
 12.78 CCL2 CCL5 CCR5 CXCL10 CXCL9
6
Human cytomegalovirus infection 38
Show member pathways
 12.77 CCL2 CCL5 CCR5 DDX58 IL1B IRF3
7
TRAF Pathway 65
Show member pathways
 12.51 IL1B IRF3 TICAM1 TLR3 TRAF3
8
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 67
Show member pathways
 12.42 CCL5 CXCL10 DDX58 IL1B IRF3 TICAM1
9
Cytosolic sensors of pathogen-associated DNA 67
Show member pathways
 12.32 DDX58 IRF3 TICAM1 TLR3
10
IL-17 Family Signaling Pathways 66
Show member pathways
 12.22 CCL2 CXCL10 IL1B TRAF3
11
Toll Comparative Pathway 65
Show member pathways
 12.2 IL1B IRF3 TICAM1 TLR3
12
Diseases associated with the TLR signaling cascade 67
Show member pathways
 12.15 IRF3 TICAM1 TLR3 TRAF3
13
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 12.1 CCL2 CCL5 CCR5 CXCL10 CXCL9 IL1B
14
Spinal Cord Injury 1
11.92 CCL2 CXCL10 GFAP IL1B
15
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 66
Show member pathways
 11.9 CCL2 CCL5 CCR5 CXCL10 CXCL9
16
TNF signaling pathway 38
11.84 CCL2 CCL5 CXCL10 IL1B TRAF3
17
NF-kappaB Signaling 4
11.84 CCL2 CCL5 CXCL10 DDX58 IL1B IRF3
18
NF-kappa B signaling pathway 38
11.83 DDX58 IL1B TICAM1 TRAF3
19
Rheumatoid arthritis 38
11.75 CCL2 CCL5 IL1B
20
Pertussis 38
11.66 IL1B IRF3 TICAM1
21
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.62 CCL2 CCL5 CXCL10 CXCL9 IL1B
22
Lung fibrosis 1
11.55 CCL2 CCL5 IL1B
23
Type II interferon signaling (IFNG) 1
11.3 CXCL10 CXCL9 IL1B
24
G-protein signaling_RhoB regulation pathway 23
11.12 CCL2 CCL5 CXCL10 CXCL9 IL1B
25
Interleukin-10 signaling 67
11.04 CCL2 CCL5 CCR5 CXCL10 IL1B
26
G-protein signaling_Rap2B regulation pathway 23
10.93 CCL2 CCL5 CXCL10 CXCL9 GFAP IL1B
27
LDL Oxidation in Atherogenesis 65
10.84 CCL2 IL1B
Sources

GO Terms for Encephalitis

About this section

Cellular components related to Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 host cell GO:0043657 8.8 CD209 CLEC4M XPO1

Biological processes related to Encephalitis according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.97 IL1B IRF3 TICAM1 TLR3
2 inflammatory response GO:0006954 9.97 CCL2 CCL5 CCR5 CXCL10 CXCL9 IL1B
3 innate immune response GO:0045087 9.97 CD209 CLEC4M DDX58 IRF3 RSAD2 TICAM1
4 defense response GO:0006952 9.96 CCR5 CXCL10 CXCL9 TLR3
5 chemotaxis GO:0006935 9.96 CCL2 CCL5 CCR5 CXCL10 CXCL9
6 response to virus GO:0009615 9.91 CCL5 CXCL10 DDX58 RSAD2 TLR3
7 cellular response to interferon-gamma GO:0071346 9.89 CCL2 CCL5 TLR3
8 cell chemotaxis GO:0060326 9.89 CCL2 CCL5 CCR5 CXCL10
9 viral entry into host cell GO:0046718 9.88 CD209 CLEC4G CLEC4M RPSA
10 neutrophil chemotaxis GO:0030593 9.88 CCL2 CCL5 CXCL10 CXCL9 IL1B
11 cellular response to organic cyclic compound GO:0071407 9.87 CCL2 CCL5 IL1B
12 positive regulation of interleukin-6 production GO:0032755 9.87 DDX58 IL1B TICAM1 TLR3
13 positive regulation of T cell proliferation GO:0042102 9.86 CCL5 CD209 IL1B
14 response to lipopolysaccharide GO:0032496 9.84 CXCL10 IL1B TICAM1
15 protein kinase B signaling GO:0043491 9.83 CCL2 CCL5 IL1B
16 chemokine-mediated signaling pathway GO:0070098 9.83 CCL2 CCL5 CCR5 CXCL10 CXCL9
17 toll-like receptor signaling pathway GO:0002224 9.82 TLR3 TRAF3 UNC93B1
18 positive regulation of type I interferon production GO:0032481 9.82 IRF3 TICAM1 TLR3
19 response to bacterium GO:0009617 9.8 CCL2 CXCL10 CXCL9
20 leukocyte cell-cell adhesion GO:0007159 9.79 CCL5 CD209 CLEC4M
21 positive regulation of interleukin-8 production GO:0032757 9.79 DDX58 IL1B TLR3
22 positive regulation of interferon-beta production GO:0032728 9.78 DDX58 IRF3 TLR3
23 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.76 IRF3 TICAM1 TLR3 TRAF3
24 viral genome replication GO:0019079 9.75 CCL2 CD209 CLEC4M
25 necroptotic process GO:0070266 9.72 TICAM1 TLR3
26 positive regulation of monocyte chemotaxis GO:0090026 9.72 CCL5 CXCL10
27 dendritic cell chemotaxis GO:0002407 9.72 CCL5 CCR5
28 positive regulation of glial cell proliferation GO:0060252 9.72 GFAP IL1B
29 intracellular transport of virus GO:0075733 9.72 CD209 CLEC4M XPO1
30 cellular response to exogenous dsRNA GO:0071360 9.71 DDX58 TLR3
31 positive regulation of T cell migration GO:2000406 9.71 CCL5 CXCL10
32 macrophage chemotaxis GO:0048246 9.71 CCL2 CCL5
33 positive regulation of interferon-alpha production GO:0032727 9.71 DDX58 IRF3
34 toll-like receptor 3 signaling pathway GO:0034138 9.71 TICAM1 TLR3 UNC93B1
35 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.7 TICAM1 TLR3
36 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.7 DDX58 IL1B
37 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IL1B TICAM1 TLR3
38 positive regulation of interferon-beta biosynthetic process GO:0045359 9.69 TICAM1 TLR3
39 modulation by virus of host morphology or physiology GO:0019048 9.68 CD209 CLEC4M
40 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.68 TICAM1 TLR3
41 cell-cell recognition GO:0009988 9.68 CD209 CLEC4M
42 negative regulation of macrophage apoptotic process GO:2000110 9.68 CCL5 CCR5
43 positive regulation of myeloid dendritic cell cytokine production GO:0002735 9.67 DDX58 TICAM1
44 response to exogenous dsRNA GO:0043330 9.67 DDX58 TICAM1 TLR3
45 detection of virus GO:0009597 9.66 DDX58 TLR3
46 virion attachment to host cell GO:0019062 9.66 CD209 CLEC4M
47 peptide antigen transport GO:0046968 9.64 CD209 CLEC4M
48 cellular response to lipopolysaccharide GO:0071222 9.63 CCL2 CCR5 CXCL10 CXCL9 IL1B TICAM1
49 viral process GO:0016032 9.61 CCR5 CD209 CLEC4G CLEC4M DDX58 IRF3
50 lipopolysaccharide-mediated signaling pathway GO:0031663 9.56 CCL2 CCL5 IL1B TICAM1

Molecular functions related to Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.55 CCL2 CCL5 CXCL10 CXCL9 IL1B
2 virion binding GO:0046790 9.37 CD209 CLEC4M
3 CXCR3 chemokine receptor binding GO:0048248 9.26 CXCL10 CXCL9
4 chemokine activity GO:0008009 9.26 CCL2 CCL5 CXCL10 CXCL9
5 virus receptor activity GO:0001618 9.02 CCR5 CD209 CLEC4G CLEC4M RPSA
6 protein binding GO:0005515 10.25 CCL2 CCL5 CCR5 CD209 CLEC4G CXCL10
Sources

Sources for Encephalitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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