MCID: ENC005
MIFTS: 43

Encephalomalacia

Categories: Neuronal diseases
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Aliases & Classifications for Encephalomalacia

MalaCards integrated aliases for Encephalomalacia:

Name: Encephalomalacia 11 53 43 14 16 71 75

Classifications:



External Ids:

Disease Ontology 11 DOID:2034
MeSH 43 D004678
NCIt 49 C98920
SNOMED-CT 68 58762006
UMLS 71 C0014068

Summaries for Encephalomalacia

Disease Ontology: 11 A brain disease that is characterized by cerebral softening located in cerebrum has material basis in injured or dead cells of the central nervous system.

MalaCards based summary: Encephalomalacia is related to neonatal hypoxic and ischemic brain injury and encephalitis. An important gene associated with Encephalomalacia is SUOX (Sulfite Oxidase), and among its related pathways/superpathways are Overview of interferons-mediated signaling pathway and MAPK signaling pathway. The drugs Hydrocortisone succinate and Hydrocortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include cerebrum has_material_basis_in injured, brain and occipital lobe, and related phenotypes are homeostasis/metabolism and nervous system

Related Diseases for Encephalomalacia

Diseases related to Encephalomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 680)
# Related Disease Score Top Affiliating Genes
1 neonatal hypoxic and ischemic brain injury 30.8 MBP BDNF
2 encephalitis 30.6 TNF IL6 IL1B GFAP
3 disseminated intravascular coagulation 30.4 TNF IL6 CRP
4 hemiplegia 30.4 SUOX S100B CRP
5 bacterial meningitis 30.4 TNF IL1B CRP
6 meningitis 30.3 TNF S100B IL6 IL1B CRP
7 viral encephalitis 30.3 TNF MBP IL6 IL1B
8 molybdenum cofactor deficiency 30.2 SUOX MOCS2 MOCS1
9 sulfite oxidase deficiency, isolated 30.2 SUOX MOCS2 MOCS1
10 brain edema 30.2 IL6 IL1B GFAP CRP
11 pancreatitis 30.0 TNF IL6 IL1B CRP
12 spondylosis 30.0 TNF IL6 IL1B CRP
13 vasculitis 30.0 TNF IL6 IL1B CRP
14 mumps 30.0 TNF IL6 IL1B
15 rubella 30.0 TNF IL6 IL1B
16 acute pancreatitis 30.0 TNF IL6 IL1B CRP
17 neuroma 30.0 S100B IL6 GFAP
18 hepatic encephalopathy 29.9 TNF S100B IL6
19 carotid stenosis 29.9 TNF S100B MTHFR CRP
20 atherosclerosis susceptibility 29.9 TNF MTHFR IL6 IL1B CRP
21 inherited metabolic disorder 29.9 TNF IL6 IL1B CRP
22 asphyxia neonatorum 29.9 S100B IL6 IL1B EPO CRP CASP3
23 deficiency anemia 29.8 TNF IL6 IL1B EPO CRP
24 respiratory failure 29.8 TNF IL6 IL1B CRP
25 pre-eclampsia 29.8 TNF MTHFR IL6 IL1B CRP
26 mental depression 29.8 TNF IL6 IL1B CRP BDNF
27 acquired immunodeficiency syndrome 29.7 TNF MBP IL6 IL1B EPO CRP
28 meningoencephalitis 29.7 TNF MBP IL6 IL1B CRP BDNF
29 toxic encephalopathy 29.4 TNF IL6 IL1B GFAP CASP3 BDNF
30 stroke, ischemic 29.4 TNF MTHFR MBP IL6 IL1B GFAP
31 intracranial berry aneurysm 29.3 TNF S100B IL6 IL1B EPO CRP
32 hydrocephalus 29.2 TNF S100B MTHFR MBP GFAP EPO
33 cerebral palsy 28.9 TNF S100B OLIG2 MTHFR MBP IL6
34 nervous system disease 28.7 TNF S100B OLIG2 MTHFR MBP IL6
35 periventricular leukomalacia 28.3 TNF S100B OLIG2 OLIG1 MBP IL6
36 porencephaly 11.2
37 encephalomalacia, multilocular 11.0
38 external pathological resorption 10.4 TNF IL6
39 third ventricle chordoid glioma 10.4 OLIG2 GFAP
40 non-syndromic x-linked intellectual disability 96 10.4 IL1B AIF1
41 molybdenum cofactor deficiency, complementation group c 10.4 SUOX MOCS2 MOCS1
42 biotinidase deficiency 10.4 SUOX MTHFR MOCS1
43 molybdenum cofactor deficiency, complementation group b 10.4 SUOX MOCS2 MOCS1
44 periodontitis, chronic 10.4 IL6 IL1B
45 molybdenum cofactor deficiency, complementation group a 10.4 SUOX MOCS2 MOCS1
46 cerebral creatine deficiency syndrome 2 10.4 SUOX MOCS2 MOCS1
47 xanthinuria 10.4 SUOX MOCS2 MOCS1
48 epilepsy, pyridoxine-dependent 10.4 SUOX MOCS2 MOCS1
49 osteosclerotic myeloma 10.4 IL6 IL1B
50 methylmalonic aciduria and homocystinuria, cblc type 10.4 MTHFR MOCS2 MOCS1

Graphical network of the top 20 diseases related to Encephalomalacia:



Diseases related to Encephalomalacia

Symptoms & Phenotypes for Encephalomalacia

GenomeRNAi Phenotypes related to Encephalomalacia according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.18 AIF1 BDNF CASP3 CRP EPO GFAP
2 no effect GR00402-S-2 10.18 AIF1 BDNF CASP3 CRP EPO GPR17

MGI Mouse Phenotypes related to Encephalomalacia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.22 AIF1 BDNF CASP3 CRP EPO GFAP
2 nervous system MP:0003631 10.21 AIF1 BDNF CASP3 GFAP GPR17 GPX4
3 growth/size/body region MP:0005378 10.1 AIF1 BDNF CASP3 GFAP GPX4 IL1B
4 vision/eye MP:0005391 9.9 AIF1 BDNF CASP3 GFAP GPX4 IL6
5 mortality/aging MP:0010768 9.8 BDNF CASP3 EPO GFAP GPX4 IL1B
6 integument MP:0010771 9.32 BDNF CASP3 IL1B IL6 MOCS1 MOCS2

Drugs & Therapeutics for Encephalomalacia

Drugs for Encephalomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone succinate Approved Phase 2 2203-97-6 3643
2
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
3
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 3640 5754
4 Anti-Inflammatory Agents Phase 2
5 Hydrocortisone 17-butyrate 21-propionate Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Trial of Hydrocortisone in Very Preterm Infants at High Risk for Neurologic and Pulmonary Impairments Completed NCT00167544 Phase 2 Hydrocortisone;Placebo

Search NIH Clinical Center for Encephalomalacia

Cochrane evidence based reviews: encephalomalacia

Genetic Tests for Encephalomalacia

Anatomical Context for Encephalomalacia

Organs/tissues related to Encephalomalacia:

FMA: Cerebrum Has_material_basis_in Injured
MalaCards : Brain, Occipital Lobe, Temporal Lobe, Cerebellum, Subthalamic Nucleus, Caudate Nucleus, Thalamus

Publications for Encephalomalacia

Articles related to Encephalomalacia:

(show top 50) (show all 891)
# Title Authors PMID Year
1
Proton magnetic resonance spectroscopy and diffusion-weighted imaging in isolated sulfite oxidase deficiency. 53 62
16970890 2006
2
Isolated sulfite oxidase deficiency: a case report with a novel mutation and review of the literature. 53 62
16140720 2005
3
Paenibacillus dendritiformis Meningitis, Brain Abscesses and Cystic Encephalomalacia in an Infant: Case Presentation and Review of the Literature. 62
36102712 2022
4
Brain-clinical signatures for vagus nerve stimulation response. 62
36415145 2022
5
[Analysis of clinical and imaging features of 6 cases of linear scleroderma en coup de sabre with central nervous system involvement in children]. 62
36319148 2022
6
Dyke-Davidoff-Masson syndrome: Imaging diagnosis in an asymptomatic adult. 62
36132061 2022
7
Repetitive mild TBI causes pTau aggregation in nigra without altering preexisting fibril induced Parkinson's-like pathology burden. 62
36435806 2022
8
Moyamoya associated with Turner syndrome in a patient with type 2 spinocerebellar ataxia-Occam's razor or Hickam's dictum: a case report. 62
36209056 2022
9
Cognitive impairment in epilepsy patients and its correlations. 62
36269892 2022
10
Uncommon histopathological features of cytomegalovirus encephalitis and measles inclusion body encephalitis on autopsy in two patients with primary immunodeficiency. 62
36278299 2022
11
[A multicenter epidemiological study of acute bacterial meningitis in children]. 62
36207852 2022
12
Adult intracranial infection caused by an extended-spectrum-beta-lactamase-producing strain of hypervirulent Klebsiella pneumoniae: a case report. 62
36172112 2022
13
Pathology and Pathogenesis of Brain Lesions Produced by Clostridium perfringens Type D Epsilon Toxin. 62
36012315 2022
14
Chicken embryo lethality assay for determining the lethal dose, tissue distribution and pathogenicity of clinical Enterococcus cecorum isolates from poultry. 62
35739309 2022
15
Imaging in medically refractory epilepsy at 3 Tesla: a 13-year tertiary adult epilepsy center experience. 62
35661273 2022
16
Cerebrovascular Complications of Vestibular Schwannoma Surgery. 62
35832937 2022
17
Multiple brain abscesses in an extremely preterm infant and a 12-year follow up: a case report. 62
35710574 2022
18
Cerebral palsy and the placenta: A review of the maternal-placental-fetal origins of cerebral palsy. 62
35196502 2022
19
Genotype-Phenotype Dissociation in Two Taiwanese Children with Molybdenum Cofactor Deficiency Caused by MOCS2 Mutation. 62
34674206 2022
20
Which is the Most Common Physiologic Type of Cerebral Palsy? 62
35864637 2022
21
Multimodal Imaging of a Severe Case of Neonatal Acute Retinal Necrosis and Lens Vacuoles Associated with Herpes Simplex Virus Infection. 62
33539717 2022
22
Impact of Encephalomalacia and White Matter Hyperintensities on ASPECTS in Patients With Acute Ischemic Stroke: Comparison of Automated and Radiologist-Derived Scores. 62
34910537 2022
23
Presentation, Etiology, Outcome, and Differentiation of Visual Semiology of Adult Occipital Epilepsy From Visual Aura of Migraine Headache: A Prospective Study in a Tertiary Care Center in Bangladesh. 62
35592185 2022
24
Cystic Encephalomalacia in a Young Woman After Cardiac Arrest Due to Diabetic Ketoacidosis and Thyroid Storm. 62
35505739 2022
25
Heterogeneous immunoreactivity of axonal spheroids in focal symmetrical encephalomalacia produced by Clostridium perfringens type D epsilon toxin in sheep. 62
34872408 2022
26
Hippocampal injury in patients with status epilepticus: Quantitative analysis of hippocampal volume and structural co-variance network. 62
35030375 2022
27
Focal cortical dysplasia links to sleep-related epilepsy in symptomatic focal epilepsy. 62
34968776 2022
28
Screening of Risk Factors for Poor Prognosis in Patients with Refractory Epilepsy Secondary to Encephalomalacia. 62
35832138 2022
29
Posttraumatic epilepsy: A single institution case series in Indonesia. 62
35928318 2022
30
Pre-Existing Non-Disabling Encephalomalacia Confers Risk to Stroke Outcomes After Endovascular Treatment. 62
35222256 2022
31
Religious conversion in an older male with longstanding epilepsy. 62
35528136 2022
32
Distinctive Neuroimaging Pattern in Term Newborns With Neonatal Placental Encephalopathy: A Case Series. 62
34740136 2022
33
Factor XIII deficiency in a neonate presenting as subpial haemorrhage. 62
35747783 2022
34
Fetal Brain Injury in Rhesus Isoimmunization Fetus. 62
35103225 2022
35
Encephalomalacia/gliosis, deep venous thrombosis, and cancer in Arg393His antithrombin Hanoi and the potential impact of the β-amyloid precursor protein (APP) on thrombosis and cancer. 62
35860682 2022
36
Deep learning to automate the labelling of head MRI datasets for computer vision applications. 62
34286375 2022
37
Association Between Antemortem FLAIR White Matter Hyperintensities and Neuropathology in Brain Donors Exposed to Repetitive Head Impacts. 62
34819338 2022
38
Striatal necrosis caused by Lichtheimia ramosa in a neonatal calf. 62
34707018 2021
39
Recurrent migraine with binocular transient vision loss associated with acute stroke: A case report. 62
34917346 2021
40
Intracortical focal non-convulsive status epilepticus causing cerebral hypoxia and intracranial hypertension. 62
34668863 2021
41
Abdominal epilepsia partialis continua in a patient with astrocytoma treated with Lacosamide - value of repetitive EEG recordings. 62
34730207 2021
42
Moyamoya disease: a spectrum of clinical and radiological findings in a series of eight paediatric patients. 62
33539002 2021
43
Surgical candidates in children with epileptic spasms can be selected without invasive monitoring: A report of 70 cases. 62
34339941 2021
44
Pediatric moyamoya MRI score: an imaging-based scale to predict outcomes in surgically treated pediatric patients with moyamoya. 62
34469869 2021
45
Magnetic resonance imaging diagnosis of causes of cerebral palsy in a developing country: A database of South African children. 62
34949258 2021
46
Eye Blink-Associated Saccades. 62
34692316 2021
47
Cerebrospinal Fluid Leaks From the Lateral Ventricle: A Case Series. 62
34121080 2021
48
Multicystic Encephalomalacia: The Neuropathology of Systemic Neonatal Parechovirus Infection. 62
33754905 2021
49
A Rare Case of Intraparenchymal Cerebrospinal Fluid Cyst Associated With Ventriculoperitoneal Shunt in an Adult Patient. 62
34589330 2021
50
Imaging Features to Predict Response to Olfactory Training in Post-Traumatic Olfactory Dysfunction. 62
33449371 2021

Variations for Encephalomalacia

Expression for Encephalomalacia

Search GEO for disease gene expression data for Encephalomalacia.

Pathways for Encephalomalacia

Pathways related to Encephalomalacia according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.52 TNF IL6 IL1B EPO CASP3 BDNF
2 12.32 TNF IL1B CASP3 BDNF
3 11.92 BDNF CASP3 IL1B IL6 TNF
4 11.8 TNF IL6 IL1B GFAP BDNF
5 11.74 OLIG2 OLIG1 MBP GFAP
6
Show member pathways
11.69 IL6 CRP CASP3
7 11.67 IL6 CASP3 AIF1
8 11.66 TNF IL6 IL1B
9 11.63 TNF IL6 CRP
10 11.57 IL1B IL6 TNF
11
Show member pathways
11.57 IL1B IL6 TNF
12 11.55 TNF IL6 IL1B
13 11.54 TNF IL6 IL1B CASP3
14 11.41 TNF IL6 IL1B
15 11.38 TNF IL6 IL1B
16 11.29 TNF MBP IL6 IL1B GFAP CASP3
17 11.25 S100B OLIG2 OLIG1 GFAP BDNF
18 11.24 IL1B IL6 TNF
19 11.19 TNF IL6 IL1B
20 11.15 TNF IL6 IL1B
21 11.12 TNF IL6 IL1B
22 11.08 TNF IL6 IL1B
23 10.93 TNF IL6 IL1B GFAP BDNF
24 10.9 TNF OLIG2 OLIG1 IL1B
25 10.86 TNF IL6 CRP
26 10.72 IL6 IL1B
27 10.35 SUOX MOCS2
28
Show member pathways
10.27 TNF IL6

GO Terms for Encephalomalacia

Cellular components related to Encephalomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 molybdopterin synthase complex GO:0019008 8.92 MOCS2 MOCS1

Biological processes related to Encephalomalacia according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 10.14 CRP IL1B IL6 TNF
2 regulation of insulin secretion GO:0050796 10.07 TNF IL6 IL1B
3 positive regulation of nitric oxide biosynthetic process GO:0045429 10.04 TNF IL1B AIF1
4 response to glucocorticoid GO:0051384 10.01 TNF IL6 CASP3 AIF1
5 acute-phase response GO:0006953 10 IL6 EPO CRP
6 response to interleukin-1 GO:0070555 9.99 MTHFR IL1B EPO
7 negative regulation of neurogenesis GO:0050768 9.91 TNF IL6 IL1B
8 positive regulation of chemokine production GO:0032722 9.91 TNF IL6 IL1B AIF1
9 Mo-molybdopterin cofactor biosynthetic process GO:0006777 9.88 MOCS2 MOCS1
10 positive regulation of mononuclear cell migration GO:0071677 9.88 TNF AIF1
11 positive regulation of fever generation GO:0031622 9.86 TNF IL1B
12 oligodendrocyte differentiation GO:0048709 9.85 OLIG2 OLIG1 GPR17
13 positive regulation of interleukin-6 production GO:0032755 9.85 TNF MBP IL6 IL1B AIF1
14 sequestering of triglyceride GO:0030730 9.8 TNF IL1B
15 positive regulation of neuroinflammatory response GO:0150078 9.8 TNF IL6 IL1B
16 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.76 IL1B TNF
17 negative regulation of lipid storage GO:0010888 9.73 CRP IL6 TNF
18 molybdopterin cofactor biosynthetic process GO:0032324 9.65 MOCS2 MOCS1
19 vascular endothelial growth factor production GO:0010573 9.43 TNF IL6 IL1B
20 positive regulation of glial cell proliferation GO:0060252 9.17 TNF IL6 IL1B GFAP

Sources for Encephalomalacia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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