MCID: ENC005
MIFTS: 37

Encephalomalacia

Categories: Neuronal diseases

Aliases & Classifications for Encephalomalacia

MalaCards integrated aliases for Encephalomalacia:

Name: Encephalomalacia 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2034
MeSH 44 D004678
NCIt 50 C98920
SNOMED-CT 68 58762006
UMLS 73 C0014068

Summaries for Encephalomalacia

Disease Ontology : 12 A brain disease that is characterized by cerebral softening located in cerebrum has material basis in injured or dead cells of the central nervous system.

MalaCards based summary : Encephalomalacia is related to porencephaly and traumatic brain injury. An important gene associated with Encephalomalacia is SUOX (Sulfite Oxidase), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Antifolate resistance. The drugs Magnesium Sulfate and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and liver, and related phenotype is mortality/aging.

Wikipedia : 76 In medicine, cerebral softening (encephalomalacia) is a localized softening of the brain substance, due... more...

Related Diseases for Encephalomalacia

Diseases related to Encephalomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 porencephaly 32.4 MTHFR SIX3
2 traumatic brain injury 29.9 IL6 MBP
3 brain injury 29.9 IL6 MBP
4 viral encephalitis 29.8 IL6 MBP
5 encephalomalacia, multilocular 12.1
6 molybdenum cofactor deficiency, complementation group b 10.2 MOCS1 MOCS2
7 molybdenum cofactor deficiency, complementation group a 10.2 MOCS1 MOCS2
8 epilepsy 10.1
9 encephalitis 10.1
10 sudden sensorineural hearing loss 10.1 IL6 MTHFR
11 osteoporotic fracture 10.1 IL6 MTHFR
12 gastroschisis 10.1 IL6 MTHFR
13 ischemic heart disease 10.1 IL6 MTHFR
14 central retinal vein occlusion 10.1 IL6 MTHFR
15 retinal vein occlusion 10.1 IL6 MTHFR
16 transverse myelitis 10.1 IL6 MBP
17 myelitis 10.1 IL6 MBP
18 transient arthritis 10.1 IL6 MBP
19 retinal artery occlusion 10.1 IL6 MTHFR
20 viral infectious disease 10.1
21 meningitis 10.1
22 hematopoietic stem cell transplantation 10.1 IL6 MTHFR
23 holocarboxylase synthetase deficiency 10.1 MTHFR PC
24 neuromyelitis optica 10.0 IL6 MBP
25 radiculopathy 10.0 AVPR2 IL6
26 meningoencephalitis 10.0 IL6 MBP
27 hydranencephaly 10.0
28 pancreatitis 10.0
29 herpes simplex 10.0
30 muscular dystrophy 10.0
31 preterm premature rupture of the membranes 10.0 CPVL IL6
32 methylmalonic aciduria due to methylmalonyl-coa mutase deficiency 10.0 MTHFR PC
33 molybdenum cofactor deficiency 10.0 MOCS1 MOCS2 MOCS3 SUOX
34 spinal cord disease 9.9 AVPR2 IL6 MBP
35 schizencephaly 9.9 MTHFR SIX3
36 placenta disease 9.9 IL6 MTHFR
37 alzheimer disease 9.8
38 schizophrenia 9.8
39 3-methylglutaconic aciduria, type iii 9.8
40 propionic acidemia 9.8
41 myocardial infarction 9.8
42 diabetes mellitus, ketosis-prone 9.8
43 hyperprolactinemia 9.8
44 cerebral hemorrhage 9.8
45 lennox-gastaut syndrome 9.8
46 lymphoma 9.8
47 partial optic atrophy 9.8
48 disseminated intravascular coagulation 9.8
49 hepatic coma 9.8
50 cerebral atherosclerosis 9.8

Graphical network of the top 20 diseases related to Encephalomalacia:



Diseases related to Encephalomalacia

Symptoms & Phenotypes for Encephalomalacia

MGI Mouse Phenotypes related to Encephalomalacia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.28 AVPR2 CPVL IL6 MBP MOCS2 MTHFR

Drugs & Therapeutics for Encephalomalacia

Drugs for Encephalomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 3 7487-88-9 24083
2 Analgesics Phase 4,Phase 3,Phase 1,Phase 2
3 Central Nervous System Depressants Phase 4,Phase 3
4 Anticonvulsants Phase 4,Phase 3
5 Anesthetics Phase 4,Phase 3
6 Tocolytic Agents Phase 4,Phase 3,Phase 1,Phase 2
7 Anti-Arrhythmia Agents Phase 4,Phase 3
8 Calcium, Dietary Phase 4,Phase 3
9 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
10 calcium channel blockers Phase 4,Phase 3
11
Nitric Oxide Approved Phase 2, Phase 3 10102-43-9 145068
12 Hematinics Phase 3,Phase 1,Phase 2
13 Epoetin alfa Phase 3,Phase 1,Phase 2 113427-24-0
14 Endothelium-Dependent Relaxing Factors Phase 2, Phase 3
15 Protective Agents Phase 2, Phase 3
16 Vasodilator Agents Phase 2, Phase 3
17 Neurotransmitter Agents Phase 2, Phase 3
18 Free Radical Scavengers Phase 2, Phase 3
19 Antioxidants Phase 2, Phase 3
20 Anti-Asthmatic Agents Phase 2, Phase 3
21 Respiratory System Agents Phase 2, Phase 3
22 Autonomic Agents Phase 2, Phase 3
23 Bronchodilator Agents Phase 2, Phase 3
24 Acidophilus Phase 3
25
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
26
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
27
Cefoxitin Approved Phase 2 35607-66-0 441199
28
Ampicillin Approved, Vet_approved Phase 2 69-53-4 6249
29
Cefotaxime Approved Phase 2 63527-52-6 456256 5742673
30
Indomethacin Approved, Investigational Phase 1, Phase 2 53-86-1 3715
31
Mineral oil Approved, Vet_approved Phase 2 8042-47-5
32
Calcium polycarbophil Approved Phase 2 126040-58-2
33
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
34 Pharmaceutical Solutions Phase 1, Phase 2,Phase 2,Not Applicable
35 Hydrocortisone 17-butyrate 21-propionate Phase 2
36 Anti-Inflammatory Agents Phase 2,Phase 1
37 Hydrocortisone-17-butyrate Phase 2
38 Cortisol succinate Phase 2
39 Antitubercular Agents Phase 2
40 Gentamicins Phase 2
41 Anti-Bacterial Agents Phase 2
42 Anti-Infective Agents Phase 2
43 Antibiotics, Antitubercular Phase 2
44 Analgesics, Non-Narcotic Phase 1, Phase 2
45 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
46 Antirheumatic Agents Phase 1, Phase 2
47 Cyclooxygenase Inhibitors Phase 1, Phase 2
48 Progestins Phase 2
49 Psyllium Phase 2
50 Hormones Phase 2

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth Completed NCT00120588 Phase 4 magnesium
2 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3 magnesium sulfate
3 Effect of Erythropoietin in Premature Infants on White Matter Lesions and Neurodevelopmental Outcome Recruiting NCT03110341 Phase 3 Erythropoietin;Normal saline
4 Inhaled Nitric Oxide and Neuroprotection in Premature Infants Active, not recruiting NCT00515281 Phase 2, Phase 3 inhaled nitric oxide;oxygen
5 Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity Terminated NCT00303082 Phase 3 Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC-14
6 Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants Unknown status NCT00910234 Phase 1, Phase 2 recombinant human erythropoietin (rhEpo);recombinant human erythropoietin (rhEpo);Normal saline
7 Randomized Trial of Hydrocortisone in Very Preterm High-Risk Infants Completed NCT00167544 Phase 2 Hydrocortisone;Placebo
8 Does Erythropoietin Improve Outcome in Very Preterm Infants? Completed NCT00413946 Phase 2 Recombinant human Erythropoietin;saline
9 Antibiotic "Dysbiosis" in Preterm Infants Recruiting NCT02784821 Phase 2 Antibiotic;Antibiotics - pre-emptive
10 Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury Recruiting NCT02221219 Phase 1, Phase 2 Indomethacin;placebo infusion
11 Randomized Trial of Maternal Progesterone Therapy Recruiting NCT02133573 Phase 2 Progesterone;Vaginal lubricant
12 Efficacy of Allogeneic Umbilical Cord Derived Hematopoietic and Mesenchymal Stem Cells in Cerebral Palsy Active, not recruiting NCT03795974 Phase 2
13 High-Dose Erythropoietin in Extremely Premature Infants to Prevent/Attenuate Brain Injury: A Phase II Study Terminated NCT00589953 Phase 2 Erythropoietin;Saline placebo
14 S100B as a Marker of Brain Injury of Preterm Infants Unknown status NCT02082535
15 Telerehabilitation of Working Memory in Children With Periventricular Leukomalacia and Bilateral Cerebral Palsy Completed NCT02342990 Not Applicable
16 In Utero Magnesium Sulfate Exposure: Effects on Extremely-Low-Birth-Weight Infants Completed NCT01203501
17 Umbilical Cord Blood Proteomic Analysis and Neonatal Brain Injury Completed NCT00375908
18 Liberal Versus Restrictive Transfusion Guidelines for Preterm Infants Completed NCT00369005 Not Applicable
19 Randomized Controlled Trial of Early Intensive Leg Exercise to Improve Walking in Children With Diplegia Recruiting NCT03672877 Not Applicable
20 Single-session tDCS in Cerebral Palsy Recruiting NCT03635775 Not Applicable
21 Prediction of Brain Injury in Premature Infants Recruiting NCT02814383
22 Evaluation of Long-Term Gait Development in Infants With Neonatal Encephalopathy Using Infant Treadmill Not yet recruiting NCT03534466 Not Applicable
23 Evaluation of Long-term Neurodevelopment in Neonatal Encephalopathy by Infant Treadmill Not yet recruiting NCT03527498 Not Applicable

Search NIH Clinical Center for Encephalomalacia

Cochrane evidence based reviews: encephalomalacia

Genetic Tests for Encephalomalacia

Anatomical Context for Encephalomalacia

MalaCards organs/tissues related to Encephalomalacia:

41
Brain, Cerebellum, Liver, Occipital Lobe, Heart, Spinal Cord, Placenta

The Foundational Model of Anatomy Ontology organs/tissues related to Encephalomalacia:

19
Cerebrum Has_material_basis_in Injured Or Dead Cells Of The Central Nervous System

Publications for Encephalomalacia

Articles related to Encephalomalacia:

(show top 50) (show all 170)
# Title Authors Year
1
Susceptibility-weighted and diffusion kurtosis imaging to evaluate encephalomalacia with epilepsy after traumatic brain injury. ( 29761118 )
2018
2
Cystic Encephalomalacia following Vasculopathy and Vasospasm of Proximal Intracranial Arteries Due to Pneumococcal Meningitis in a Infant. ( 29523004 )
2018
3
Glioblastoma arising within sites of encephalomalacia from cerebrovascular insult: two cases and a review of the literature. ( 29422364 )
2018
4
Histopathological study of encephalomalacia in neonatal calves and application of neuronal and axonal degeneration marker. ( 29731475 )
2018
5
Association of Transsynaptic Degeneration of the Papez Circuit With Anterior Thalamic Encephalomalacia. ( 30128549 )
2018
6
Multicystic encephalomalacia secondary to head trauma. ( 28149115 )
2017
7
The Use of Ultrabrief Left Unilateral Electroconvulsive Therapy in a Patient With Cerebral Aneurysms and Right-Sided Encephalomalacia and Stroke: A Case Report. ( 28767530 )
2017
8
Abnormal parietal encephalomalacia associated with schizophrenia: A case report. ( 28272261 )
2017
9
MEG may reveal hidden population of spikes in epilepsy with porencephalic cyst/encephalomalacia. ( 27870647 )
2016
10
Partial optic atrophy and homonymous quadrantanopia in a patient with occipital encephalomalacia. ( 25810973 )
2015
11
Bilateral cystic encephalomalacia following multiple intrauterine transfusions for anti-Kell isoimmunisation. ( 25827913 )
2015
12
Bilateral Cortical Encephalomalacia in a Patient Implanted With Bilateral Deep Brain Stimulation for Alzheimer's Disease: Case Report. ( 25850733 )
2015
13
Parieto-occipital encephalomalacia in children; clinical and electrophysiological features of twenty-seven cases. ( 26167209 )
2015
14
Magnetoencephalography helps delineate the extent of the epileptogenic zone for surgical planning in children with intractable epilepsy due to porencephalic cyst/encephalomalacia. ( 25014323 )
2014
15
Prenatal diagnosis of fetal encephalomalacia after maternal diabetic ketoacidosis. ( 25452892 )
2014
16
Angioglioma misdiagnosed as encephalomalacia on magnetic resonance imaging for over a decade. ( 24651748 )
2014
17
Right frontal lobe encephalomalacia in an adult propionic acidemia patient with neuropsychiatric manifestations. ( 27896115 )
2014
18
Encephalomalacia in surviving twin after single fetal death diagnosed at 18 weeks of gestation in monochorionic twin pregnancy. ( 24009813 )
2013
19
Normal neurodevelopmental outcome despite severe and early extensive encephalomalacia: plasticity, repair or magic? ( 23789815 )
2013
20
Severe enteroviral encephalitis complicated by encephalomalacia--case presentation. ( 23272531 )
2012
21
Focal symmetrical encephalomalacia in young calves. ( 22904025 )
2012
22
Toxic equine parkinsonism: an immunohistochemical study of 10 horses with nigropallidal encephalomalacia. ( 21527781 )
2012
23
Nigropallidal encephalomalacia in horses grazing Rhaponticum repens (creeping knapweed). ( 22443332 )
2012
24
Encephalomalacia in the frontal lobe: complication of the endoscopic sinus surgery. ( 22134284 )
2011
25
Multicystic encephalomalacia as an end-stage finding in abusive head trauma. ( 21519862 )
2011
26
Hippocampal sclerosis and encephalomalacia as prognostic factors of tuberculous meningitis-related and herpes simplex encephalitis-related epilepsy. ( 21620739 )
2011
27
Parieto-occipital encephalomalacia in neonatal hyperammonemia with ornithine transcarbamylase deficiency: A case report. ( 19640662 )
2010
28
Focal symmetrical encephalomalacia in a goat. ( 20807946 )
2010
29
Functional deficiencies of sulfite oxidase: Differential diagnoses in neonates presenting with intractable seizures and cystic encephalomalacia. ( 19793632 )
2010
30
Acute retinal necrosis and cystic encephalomalacia in a premature neonate. ( 25390403 )
2010
31
Diffuse multicystic encephalomalacia in a preterm baby due to homozygous methylenetetrahydrofolate reductase 677 C-->T mutation. ( 18539994 )
2008
32
Multicystic encephalomalacia in an uncomplicated twin pregnancy. ( 18400596 )
2008
33
Prenatal multicystic encephalomalacia due to anomaly of the aortic arch. ( 17628227 )
2007
34
Encephalomalacia with Enterococcus durans infection in the brain stem and cerebral hemisphere in chicks in Japan. ( 16617999 )
2006
35
HPLC determination of free nitrogenous compounds of Centaurea solstitialis (Asteraceae), the cause of equine nigropallidal encephalomalacia. ( 16112158 )
2005
36
Hyperprolactinemia presenting with encephalomalacia-associated seizure disorder and infertility: a novel application for bromocriptine therapy in reproductive endocrinology. ( 16264405 )
2005
37
Multicystic encephalomalacia after first-trimester intrauterine fetal death in monochorionic twins. ( 14981409 )
2004
38
Focal symmetrical encephalomalacia in swine from ingestion of Aeschynomene indica seeds. ( 15587245 )
2004
39
Multicystic encephalomalacia. ( 12841409 )
2003
40
Case 46: encephalomalacia in surviving twin after death of monochorionic co-twin. ( 11997543 )
2002
41
Magnetic resonance imaging features of equine nigropallidal encephalomalacia. ( 11499702 )
2001
42
Brain, liver and plasma unsaturated aldehydes in nutritional encephalomalacia of chicks. ( 10842464 )
2000
43
Cerebellar encephalomalacia on magnetic resonance imaging after removal of acoustic tumor. ( 10388897 )
1999
44
Enterococcus-associated encephalomalacia in one-week-old chicks. ( 9823609 )
1998
45
Encephalomalacia associated with vitamin E deficiency in commercially raised emus. ( 9777163 )
1998
46
Excellent surgical results obtained in patients with a depressed frontal fracture leading to frontal encephalomalacia and intractable frontal seizures. ( 9578021 )
1998
47
Focal symmetrical encephalomalacia in a 6-month-old Dorset sheep. ( 9759513 )
1998
48
Bilateral encephalomalacia in a pig related to latent Aujeszky's disease virus infection. ( 9467307 )
1997
49
Multicystic encephalomalacia in term infants. ( 9118144 )
1996
50
Neonatal multifocal encephalomalacia and other lesions in the brains of Georgia chicks: 1991-95. ( 8980822 )
1996

Variations for Encephalomalacia

Expression for Encephalomalacia

Search GEO for disease gene expression data for Encephalomalacia.

GO Terms for Encephalomalacia

Cellular components related to Encephalomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 molybdopterin synthase complex GO:0019008 8.62 MOCS1 MOCS2

Biological processes related to Encephalomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metabolic process GO:0008152 9.43 MOCS3 MTHFR PC
2 telencephalon development GO:0021537 9.16 AVPR2 SIX3
3 molybdopterin cofactor biosynthetic process GO:0032324 9.13 MOCS1 MOCS2 MOCS3
4 Mo-molybdopterin cofactor biosynthetic process GO:0006777 8.8 MOCS1 MOCS2 MOCS3

Molecular functions related to Encephalomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 catalytic activity GO:0003824 8.92 MOCS1 MOCS3 MTHFR PC

Sources for Encephalomalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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