MCID: ENC005
MIFTS: 43

Encephalomalacia

Categories: Neuronal diseases

Aliases & Classifications for Encephalomalacia

MalaCards integrated aliases for Encephalomalacia:

Name: Encephalomalacia 12 54 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:2034
MeSH 44 D004678
NCIt 50 C98920
SNOMED-CT 67 58762006
UMLS 70 C0014068

Summaries for Encephalomalacia

Disease Ontology : 12 A brain disease that is characterized by cerebral softening located in cerebrum has material basis in injured or dead cells of the central nervous system.

MalaCards based summary : Encephalomalacia is related to encephalitis and neonatal hypoxic and ischemic brain injury. An important gene associated with Encephalomalacia is SUOX (Sulfite Oxidase), and among its related pathways/superpathways are Allograft rejection and Measles. The drugs Hydrocortisone and Hydrocortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include cerebrum has_material_basis_in injured, brain and bone, and related phenotypes are homeostasis/metabolism and integument

Wikipedia : 73 Cerebral softening, also known as encephalomalacia, is a localized softening of the substance of the... more...

Related Diseases for Encephalomalacia

Diseases related to Encephalomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 568)
# Related Disease Score Top Affiliating Genes
1 encephalitis 30.5 TNF IL6 IL1B GFAP
2 neonatal hypoxic and ischemic brain injury 30.4 MBP BDNF
3 meningitis 30.3 TNF IL6 IL1B CXCL8
4 molybdenum cofactor deficiency 30.2 SUOX MOCS2 MOCS1
5 sulfite oxidase deficiency, isolated 30.2 SUOX MOCS2 MOCS1
6 brain edema 30.1 SLC1A2 IL6 IL1B GFAP
7 angiocentric glioma 30.0 S100B GFAP
8 inherited metabolic disorder 30.0 TNF MTHFR IL6 IL1B
9 rubella 30.0 TNF IL6 IL1B
10 neuroma 29.9 S100B IL6 GFAP
11 bacterial meningitis 29.9 TNF S100B IL6 IL1B CXCL8
12 periventricular leukomalacia 29.9 TNF SLC1A2 MBP IL6 EPO
13 viral encephalitis 29.9 TNF MBP IL6 IL1B CXCL8
14 atherosclerosis susceptibility 29.9 TNF MTHFR IL6 IL1B CXCL8
15 mental depression 29.9 TNF IL6 IL1B BDNF
16 acquired immunodeficiency syndrome 29.8 TNF MBP IL6 IL1B EPO
17 mumps 29.8 TNF IL6 IL1B CXCL8
18 central nervous system disease 29.8 TNF MBP IL6 IL1B GFAP BDNF
19 acute pancreatitis 29.8 TNF IL6 IL1B CXCL8
20 carotid stenosis 29.7 TNF S100B MTHFR CXCL8
21 meningoencephalitis 29.7 TNF MBP IL6 IL1B BDNF
22 hydrocephalus 29.5 TNF S100B MTHFR MBP GFAP BDNF
23 traumatic brain injury 29.2 S100B MBP IL6 IL1B GFAP EPO
24 brain injury 29.0 S100B MBP IL6 IL1B GFAP EPO
25 cerebral palsy 29.0 TNF SLC1A2 S100B OLIG2 MTHFR IL6
26 nervous system disease 28.9 TNF MBP IL6 IL1B GFAP CXCL8
27 stroke, ischemic 28.8 TNF SLC1A2 MTHFR MBP IL6 IL1B
28 schizophrenia 28.7 TNF SLC1A2 S100B OLIG2 MTHFR MBP
29 porencephaly 11.1
30 encephalomalacia, multilocular 11.0
31 external pathological resorption 10.4 TNF IL6
32 sudden sensorineural hearing loss 10.4 MTHFR IL6
33 scorpion envenomation 10.4 TNF IL6
34 third ventricle chordoid glioma 10.4 OLIG2 GFAP
35 vibrio vulnificus infection 10.4 IL6 EPO
36 prosthetic joint infection 10.4 IL6 IL1B
37 periodontitis, chronic 10.4 IL6 IL1B
38 staphylococcal toxic shock syndrome 10.4 TNF IL1B
39 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 TNF IL6
40 cardiogenic shock 10.4 TNF IL6
41 vulvar vestibulitis syndrome 10.4 TNF IL1B
42 intracranial cysts 10.4 S100B GFAP
43 uremic pruritus 10.4 IL6 IL1B
44 indolent plasma cell myeloma 10.4 IL6 IL1B
45 palladium allergic contact dermatitis 10.4 TNF IL1B
46 kashin-beck disease 10.4 TNF IL1B
47 molybdenum cofactor deficiency, complementation group c 10.4 SUOX MOCS2 MOCS1
48 physiological polycythemia 10.4 TNF IL6 IL1B
49 gastroschisis 10.4 MTHFR IL6 IL1B
50 lumbosacral lipoma 10.4 IL1B EPO

Graphical network of the top 20 diseases related to Encephalomalacia:



Diseases related to Encephalomalacia

Symptoms & Phenotypes for Encephalomalacia

MGI Mouse Phenotypes related to Encephalomalacia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10 AIF1 BDNF CASP3 EPO GFAP IL1B
2 integument MP:0010771 9.65 BDNF CASP3 EPO IL1B IL6 MOCS2
3 nervous system MP:0003631 9.47 AIF1 BDNF CASP3 GFAP GPR17 IL1B

Drugs & Therapeutics for Encephalomalacia

Drugs for Encephalomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
2
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
3 Anti-Inflammatory Agents Phase 2
4 Hydrocortisone hemisuccinate Phase 2
5 Hydrocortisone 17-butyrate 21-propionate Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Trial of Hydrocortisone in Very Preterm Infants at High Risk for Neurologic and Pulmonary Impairments Completed NCT00167544 Phase 2 Hydrocortisone;Placebo

Search NIH Clinical Center for Encephalomalacia

Cochrane evidence based reviews: encephalomalacia

Genetic Tests for Encephalomalacia

Anatomical Context for Encephalomalacia

The Foundational Model of Anatomy Ontology organs/tissues related to Encephalomalacia:

19
Cerebrum Has_material_basis_in Injured

MalaCards organs/tissues related to Encephalomalacia:

40
Brain, Bone, Skin, Liver, Heart, Temporal Lobe, Eye

Publications for Encephalomalacia

Articles related to Encephalomalacia:

(show top 50) (show all 833)
# Title Authors PMID Year
1
Proton magnetic resonance spectroscopy and diffusion-weighted imaging in isolated sulfite oxidase deficiency. 54 61
16970890 2006
2
Isolated sulfite oxidase deficiency: a case report with a novel mutation and review of the literature. 61 54
16140720 2005
3
Robotic thermocoagulative hemispherotomy: concept, feasibility, outcomes, and safety of a new "bloodless" technique. 61
33799306 2021
4
Multicystic Encephalomalacia: The Neuropathology of Systemic Neonatal Parechovirus Infection. 61
33754905 2021
5
Case 3: Cystic Encephalomalacia and Hyperpigmented Plaques in a Preterm Infant. 61
33526643 2021
6
Multimodal Imaging of a Severe Case of Neonatal Acute Retinal Necrosis and Lens Vacuoles Associated with Herpes Simplex Virus Infection. 61
33539717 2021
7
Moyamoya disease: a spectrum of clinical and radiological findings in a series of eight paediatric patients. 61
33539002 2021
8
Patterns of Brain Injury in Perinatal Arterial Ischemic Stroke and the Development of Infantile Spasms. 61
33543672 2021
9
[Molybdenum cofactor deficiency type B manifested as Leigh-like syndrome: a case report and literature review]. 61
33548958 2021
10
Imaging Features to Predict Response to Olfactory Training in Post-Traumatic Olfactory Dysfunction. 61
33449371 2021
11
Adverse effects of erenumab on cerebral proliferative angiopathy: A case report. 61
32814432 2021
12
Novel COL4A2 mutation causing familial malformations of cortical development. 61
33577044 2021
13
Clinical and Genetic Characteristics of Mitochondrial Encephalopathy Due to FOXRED1 Mutations: Two Chinese Case Reports and a Review of the Literature. 61
33613441 2021
14
Pathology of an outbreak of highly pathogenic avian influenza A(H5N1) virus of clade 2.3.2.1a in turkeys in Bangladesh. 61
33054595 2021
15
Magnetic Resonance Imaging Findings in Childhood Epilepsy at a Tertiary Hospital in Kenya. 61
33643201 2021
16
Huge chronic subdural haematoma formation in an encephalomalacia stroke cavity. 61
33334750 2020
17
Causes of cetacean stranding and death on the Catalonian coast (western Mediterranean Sea), 2012-2019. 61
33331291 2020
18
First case report of cerebral folate deficiency caused by a novel mutation of FOLR1 gene in a Chinese patient. 61
33243190 2020
19
MR Imaging Features of Middle Cranial Fossa Encephaloceles and Their Associations with Epilepsy. 61
33033039 2020
20
Multicystic encephalomalacia: An autopsy report of 4 cases. 61
33344323 2020
21
Ingestion of foreign materials by odontocetes along the Catalan coast: causes and consequences. 61
33150872 2020
22
Successful Treatment of Psychiatric Symptoms after Traumatic Brain Injury Using Deep Brain Stimulation to the Anterior Limb of Internal Capsule-Nucleus Accumbens. 61
33124598 2020
23
Growing Skull Fracture in the Primary Motor Cortex in a 50-day-old Child: A Case Report. 61
33163438 2020
24
Long term follow up after transorbital penetrating injury: A case report. 61
32642597 2020
25
A transcranial magnetic stimulation study for the investigation of corticospinal motor pathways in children with cerebral palsy. 61
32334959 2020
26
Case Report of Immuno-Oncotherapy (IO) Provoked Encephalitis Mimicking Brain Metastasis in a Patient with History of Traumatic Brain Injury. 61
32360731 2020
27
Sequential Pathology of a Genotype XIII Newcastle Disease Virus from Bangladesh in Chickens on Experimental Infection. 61
32640621 2020
28
Electroclinical spectrum of childhood epilepsy secondary to neonatal hypoglycemic brain injury in a low resource setting: A 10-year experience. 61
32446209 2020
29
Long-term outcome of vein of Galen malformation. 61
31713850 2020
30
Mechanical Thrombectomy Using a Stent Retriever with an Intermediate Catheter for Partially Occluded Middle Cerebral Artery Fenestration. 61
32224267 2020
31
Magnetic resonance imaging features of four neonates with total brain injury. 61
31865401 2020
32
Acute Necrotizing Encephalitis in Viral Respiratory Tract Infection: An Autopsy Case Report. 61
32542125 2020
33
Traumatic microbleeds persist for up to five years following traumatic brain injury despite resolution of other acute findings on MRI. 61
32228304 2020
34
The Use of Large-Particle Aerosol Exposure to Nipah Virus to Mimic Human Neurological Disease Manifestations in the African Green Monkey. 61
31687756 2020
35
Magnetic Resonance Imaging Criteria for Post-Concussion Syndrome: A Study of 127 Post-Concussion Syndrome Patients. 61
31822164 2020
36
Cerebrospinal fluid dynamics in non-acute post-traumatic ventriculomegaly. 61
32228689 2020
37
A Pacchionian Puzzle. 61
31648659 2020
38
The impact of MEG results on surgical outcomes in patients with drug-resistant epilepsy associated with focal encephalomalacia: a single-center experience. 61
31773245 2020
39
Delayed Cerebrospinal Fluid Cleft Formation Through the Midbrain and Thalamus Following Hemicraniectomy and Cranioplasty for Acute Subdural Hematoma. 61
31218363 2020
40
Structural brain abnormalities in patients with psychogenic nonepileptic seizures. 61
31713756 2020
41
Congenital Toxoplasmosis Presenting as Eosinophilic Encephalomyelitis With Spinal Cord Hemorrhage. 61
31941759 2020
42
Surgical management of pediatric patients with encephalopathy due to electrical status epilepticus during sleep (ESES). 61
32043470 2020
43
Posterior reversible encephalopathy syndrome with ischemic infarction complicated with intrauterine fetal death: A case report. 61
31977892 2020
44
Non-convulsive status epilepticus with right arm apraxia: A case report. 61
32577612 2020
45
Acquired Hemicerebral Atrophy Secondary to Chronic Internal Carotid Steno-Occlusive Disease: A Case Series. 61
31839863 2020
46
Neurophysiological and Neuroradiological Changes in Children With Chronic Kidney Disease. 61
33313023 2020
47
Aphasic status epilepticus of frontal origin treated by resective surgery. 61
32435755 2020
48
Evaluation of Magnetic Resonance (MR) Findings in Patients with Refractory Epilepsy. 61
33312038 2020
49
Single surgeon experience with minimally invasive supraorbital craniotomy versus bifrontal craniotomy for anterior skull base meningiomas. 61
33408943 2020
50
Brain CT Findings in Patients with First-Onset Seizure Visiting the Emergency Department in Mashhad, Iran. 61
32607013 2020

Variations for Encephalomalacia

Expression for Encephalomalacia

Search GEO for disease gene expression data for Encephalomalacia.

Pathways for Encephalomalacia

Pathways related to Encephalomalacia according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.82 TNF IL6 IL1B CXCL8 CASP3
2
Show member pathways
12.8 TNF IL6 IL1B CXCL8 CASP3
3
Show member pathways
12.72 TNF IL6 IL1B CXCL8 CASP3
4
Show member pathways
12.4 TNF IL6 IL1B CXCL8
5
Show member pathways
12.31 TNF MTHFR IL6 IL1B
6
Show member pathways
12.27 TNF IL6 IL1B CXCL8 CASP3
7
Show member pathways
12.24 TNF IL6 IL1B CXCL8 BDNF
8 12.22 TNF IL6 IL1B CXCL8
9 12.21 TNF IL6 IL1B CASP3
10
Show member pathways
12.2 TNF IL6 IL1B CXCL8
11
Show member pathways
12.17 TNF IL6 IL1B CXCL8
12 12.06 TNF IL6 IL1B CXCL8
13 11.95 TNF IL6 IL1B CXCL8
14 11.93 TNF IL6 IL1B CASP3
15 11.88 OLIG2 OLIG1 MBP GFAP
16 11.85 TNF IL6 IL1B EPO
17 11.84 TNF IL6 IL1B CXCL8 CASP3
18 11.84 TNF IL6 IL1B CXCL8 CASP3 BDNF
19 11.82 TNF IL6 IL1B CXCL8
20 11.8 TNF IL6 IL1B CXCL8 CASP3
21
Show member pathways
11.74 TNF IL6 IL1B
22
Show member pathways
11.74 TNF CXCL8 CASP3
23 11.72 TNF IL6 IL1B
24 11.65 IL6 CXCL8 CASP3
25 11.62 S100B OLIG2 OLIG1 GFAP BDNF
26
Show member pathways
11.61 TNF IL6 IL1B CXCL8
27 11.6 TNF IL6 IL1B CXCL8
28 11.54 TNF IL6 IL1B CXCL8 CASP3
29 11.53 IL6 CXCL8 CASP3
30 11.5 IL6 IL1B EPO
31 11.48 TNF IL6 IL1B CXCL8
32 11.47 TNF IL6 IL1B
33 11.45 TNF IL6 IL1B CXCL8
34 11.38 TNF SLC1A2 CASP3
35 11.36 TNF IL6 IL1B
36 11.36 TNF MBP IL6 IL1B GFAP CXCL8
37 11.33 TNF IL6 IL1B
38 11.28 TNF IL6 IL1B
39 11.22 TNF IL6 IL1B
40 11.16 TNF MTHFR IL6 IL1B
41 11.11 TNF IL6 IL1B CXCL8 CASP3
42 10.99 TNF IL6 IL1B GFAP CXCL8 BDNF
43 10.98 TNF IL6 CXCL8

GO Terms for Encephalomalacia

Cellular components related to Encephalomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 molybdopterin synthase complex GO:0019008 8.62 MOCS2 MOCS1

Biological processes related to Encephalomalacia according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10.06 TNF MBP IL6 IL1B CXCL8
2 inflammatory response GO:0006954 10 TNF IL6 IL1B CXCL8 AIF1
3 cytokine-mediated signaling pathway GO:0019221 9.88 TNF IL6 IL1B CXCL8 CASP3
4 cellular response to lipopolysaccharide GO:0071222 9.87 TNF IL6 IL1B CXCL8
5 response to wounding GO:0009611 9.82 SLC1A2 GFAP CASP3
6 regulation of insulin secretion GO:0050796 9.81 TNF IL6 IL1B
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.81 TNF IL6 EPO
8 cellular response to organic cyclic compound GO:0071407 9.8 TNF IL1B CASP3
9 positive regulation of T cell proliferation GO:0042102 9.79 IL6 IL1B AIF1
10 positive regulation of smooth muscle cell proliferation GO:0048661 9.79 TNF IL6 AIF1
11 positive regulation of interleukin-8 production GO:0032757 9.78 TNF IL6 IL1B
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.71 TNF IL1B AIF1
13 response to interleukin-1 GO:0070555 9.69 MTHFR IL1B EPO
14 positive regulation of chemokine production GO:0032722 9.67 TNF IL6 AIF1
15 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.65 TNF MBP
16 regulation of establishment of endothelial barrier GO:1903140 9.65 TNF IL1B
17 response to salt stress GO:0009651 9.65 TNF EPO
18 negative regulation of lipid storage GO:0010888 9.63 TNF IL6
19 response to glucocorticoid GO:0051384 9.62 TNF IL6 CASP3 AIF1
20 response to amino acid GO:0043200 9.61 SLC1A2 MTHFR CASP3
21 positive regulation of mononuclear cell migration GO:0071677 9.59 TNF AIF1
22 molybdopterin cofactor biosynthetic process GO:0032324 9.58 MOCS2 MOCS1
23 Mo-molybdopterin cofactor biosynthetic process GO:0006777 9.58 MOCS2 MOCS1
24 oligodendrocyte differentiation GO:0048709 9.58 OLIG2 OLIG1 GPR17
25 D-aspartate import across plasma membrane GO:0070779 9.56 SLC1A2 GFAP
26 positive regulation of fever generation GO:0031622 9.55 TNF IL1B
27 negative regulation of neurogenesis GO:0050768 9.54 TNF IL6 IL1B
28 sequestering of triglyceride GO:0030730 9.52 TNF IL1B
29 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.46 TNF IL1B
30 positive regulation of neuroinflammatory response GO:0150078 9.43 TNF IL6 IL1B
31 positive regulation of interleukin-6 production GO:0032755 9.35 TNF MBP IL6 IL1B AIF1
32 vascular endothelial growth factor production GO:0010573 9.33 TNF IL6 IL1B
33 positive regulation of glial cell proliferation GO:0060252 8.92 TNF IL6 IL1B GFAP

Molecular functions related to Encephalomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TNF IL6 IL1B EPO CXCL8

Sources for Encephalomalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....