Encephalopathy, Acute, Infection-Induced 7 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Encephalopathy, Acute, Infection-Induced 7

MalaCards integrated aliases for Encephalopathy, Acute, Infection-Induced 7:

Name: Encephalopathy, Acute, Infection-Induced 7 ⁵⁸

Herpes Simplex Encephalitis, Susceptibility to, 7 ³⁰ ⁶

Iiae7 ⁵⁸ ⁷⁶

Encephalopathy, Acute, Infection-Induced , Susceptibility to, 7 ⁵⁸

Encephalopathy, Acute, Infection-Induced, Herpes-Specific, 7 ⁷⁶

Encephalitis, Herpes Simplex, Susceptibility to, Type 7 ⁴¹

Herpes Simplex Encephalitis, Susceptibility to, 5 ⁵⁸

Encephalopathy, Acute, Infection-Induced, 7 ⁷⁶

Infection-Induced Acute Encephalopathy 7 ⁷⁶

Herpes Simplex Encephalitis 5 ⁵⁸

Herpes Simplex Encephalitis 7 ⁷⁶

Hse7 ⁷⁶

Characteristics:

OMIM:

⁵⁸

Inheritance:
autosomal dominant

Miscellaneous:
variable age at onset, range teens to adult
two unrelated patients have been reported (last curated march 2018)

HPO:

³³

encephalopathy, acute, infection-induced 7:
Inheritance autosomal dominant inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases Infectious diseases Rare diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁸ 616532

MeSH ⁴⁵ D020803

MedGen ⁴³ C4225294

SNOMED-CT via HPO ⁷⁰ 128613002 246545002 25064002 more

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Summaries for Encephalopathy, Acute, Infection-Induced 7

UniProtKB/Swiss-Prot : ⁷⁶ Encephalopathy, acute, infection-induced, Herpes-specific, 7: A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.

MalaCards based summary : Encephalopathy, Acute, Infection-Induced 7, is also known as herpes simplex encephalitis, susceptibility to, 7. An important gene associated with Encephalopathy, Acute, Infection-Induced 7 is IRF3 (Interferon Regulatory Factor 3). Related phenotypes are seizures and encephalitis

Description from OMIM: 616532

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Related Diseases for Encephalopathy, Acute, Infection-Induced 7

Diseases in the Encephalopathy, Acute, Infection-Induced 4 family:

Encephalopathy, Acute, Infection-Induced 1	Encephalopathy, Acute, Infection-Induced 2
Encephalopathy, Acute, Infection-Induced 5	Encephalopathy, Acute, Infection-Induced 6
Encephalopathy, Acute, Infection-Induced 7	Encephalopathy, Acute, Infection-Induced 8

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Symptoms & Phenotypes for Encephalopathy, Acute, Infection-Induced 7

Human phenotypes related to Encephalopathy, Acute, Infection-Induced 7:

³³ (showing 4, show less)

#	Description	HPO Source Accession
1	seizures ³³	HP:0001250
2	encephalitis ³³	HP:0002383
3	headache ³³	HP:0002315
4	nuchal rigidity ³³	HP:0031179

Symptoms via clinical synopsis from OMIM:

⁵⁸

Neurologic Central Nervous System:
seizures
headache
fluctuating consciousness
acute infectious encephalitis
nuchal rigidity
more

Immunology:
increased susceptibility to herpes encephalitis (hsv-1)

Clinical features from OMIM:

616532

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Drugs & Therapeutics for Encephalopathy, Acute, Infection-Induced 7

Search Clinical Trials , NIH Clinical Center for Encephalopathy, Acute, Infection-Induced 7

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Genetic Tests for Encephalopathy, Acute, Infection-Induced 7

Genetic tests related to Encephalopathy, Acute, Infection-Induced 7:

#	Genetic test	Affiliating Genes
1	Herpes Simplex Encephalitis, Susceptibility to, 7 ³⁰	IRF3

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Anatomical Context for Encephalopathy, Acute, Infection-Induced 7

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Publications for Encephalopathy, Acute, Infection-Induced 7

Articles related to Encephalopathy, Acute, Infection-Induced 7:

(showing 2, show less)

#	Title	Authors	Year
1	Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis. ( 26513235 )	M?rk N...Mogensen TH	2015
2	Functional IRF3 deficiency in a patient with herpes simplex encephalitis. ( 26216125 )	Andersen LL...Mogensen TH	2015

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Genes for Encephalopathy, Acute, Infection-Induced 7

Genes related to Encephalopathy, Acute, Infection-Induced 7 (1 elite genes):

(showing 1, show less)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	IRF3	Interferon Regulatory Factor 3	Protein Coding	975	Molecular basis known ⁵⁸ Causative variation ⁷⁶ Genetic Tests ³⁰ Susceptibility factor ⁵⁸ Risk factor ⁶	26216125 26513235

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Variations for Encephalopathy, Acute, Infection-Induced 7

UniProtKB/Swiss-Prot genetic disease variations for Encephalopathy, Acute, Infection-Induced 7:

⁷⁶ (showing 1, show less)

#	Symbol	AA change	Variation ID	SNP ID
1	IRF3	p.Arg285Gln	VAR_075805	rs750526659

ClinVar genetic disease variations for Encephalopathy, Acute, Infection-Induced 7:

⁶ (showing 4, show less)

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	IRF3	NM_001571.5(IRF3): c.854G> A (p.Arg285Gln)	single nucleotide variant	risk factor	rs750526659	GRCh37	Chromosome 19, 50165333: 50165333
2	IRF3	NM_001571.5(IRF3): c.854G> A (p.Arg285Gln)	single nucleotide variant	risk factor	rs750526659	GRCh38	Chromosome 19, 49662076: 49662076
3	IRF3	NM_001571.5(IRF3): c.829G> A (p.Ala277Thr)	single nucleotide variant	risk factor	rs143769046	GRCh38	Chromosome 19, 49662101: 49662101
4	IRF3	NM_001571.5(IRF3): c.829G> A (p.Ala277Thr)	single nucleotide variant	risk factor	rs143769046	GRCh37	Chromosome 19, 50165358: 50165358

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Expression for Encephalopathy, Acute, Infection-Induced 7

Search GEO for disease gene expression data for Encephalopathy, Acute, Infection-Induced 7.

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Pathways for Encephalopathy, Acute, Infection-Induced 7

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GO Terms for Encephalopathy, Acute, Infection-Induced 7

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Encephalopathy, Acute, Infection-Induced 7 (IIAE7)

Aliases & Classifications for Encephalopathy, Acute, Infection-Induced 7

MalaCards integrated aliases for Encephalopathy, Acute, Infection-Induced 7:

Characteristics:

OMIM:

HPO:

Classifications:

External Ids:

Summaries for Encephalopathy, Acute, Infection-Induced 7

Related Diseases for Encephalopathy, Acute, Infection-Induced 7

Diseases in the Encephalopathy, Acute, Infection-Induced 4 family:

Symptoms & Phenotypes for Encephalopathy, Acute, Infection-Induced 7

Human phenotypes related to Encephalopathy, Acute, Infection-Induced 7:

Symptoms via clinical synopsis from OMIM:

Clinical features from OMIM:

Drugs & Therapeutics for Encephalopathy, Acute, Infection-Induced 7

Genetic Tests for Encephalopathy, Acute, Infection-Induced 7

Genetic tests related to Encephalopathy, Acute, Infection-Induced 7:

Anatomical Context for Encephalopathy, Acute, Infection-Induced 7

Publications for Encephalopathy, Acute, Infection-Induced 7

Articles related to Encephalopathy, Acute, Infection-Induced 7:

Genes for Encephalopathy, Acute, Infection-Induced 7

Genes related to Encephalopathy, Acute, Infection-Induced 7 (1 elite genes):

Variations for Encephalopathy, Acute, Infection-Induced 7

UniProtKB/Swiss-Prot genetic disease variations for Encephalopathy, Acute, Infection-Induced 7:

ClinVar genetic disease variations for Encephalopathy, Acute, Infection-Induced 7:

Expression for Encephalopathy, Acute, Infection-Induced 7

Pathways for Encephalopathy, Acute, Infection-Induced 7

GO Terms for Encephalopathy, Acute, Infection-Induced 7

Sources for Encephalopathy, Acute, Infection-Induced 7