MCID: ENC014
MIFTS: 28

Enchondroma

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Enchondroma

MalaCards integrated aliases for Enchondroma:

Name: Enchondroma 20 70

Classifications:



External Ids:

UMLS 70 C1704356

Summaries for Enchondroma

MalaCards based summary : Enchondroma is related to chondrosarcoma and enchondromatosis, multiple, ollier type, and has symptoms including pain An important gene associated with Enchondroma is IDH1 (Isocitrate Dehydrogenase (NADP(+)) 1), and among its related pathways/superpathways are Carbon metabolism and Glutathione metabolism. Affiliated tissues include bone, brain and lung.

Wikipedia : 73 An enchondroma is a benign cartilage tumour found inside bones. Typically, enchondroma is discovered on... more...

Related Diseases for Enchondroma

Diseases related to Enchondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 chondrosarcoma 31.1 IDH2 IDH1
2 enchondromatosis, multiple, ollier type 30.4 IDH2 IDH1
3 multiple enchondromatosis, maffucci type 30.2 IDH2 IDH1
4 juxtacortical chondroma 30.1 IDH2 IDH1
5 hemangioma 30.0 IDH2 IDH1
6 spindle cell hemangioma 29.6 IDH2 IDH1
7 chondroma 11.3
8 osteochondroma 10.3
9 chondroblastoma 10.1
10 osteogenic sarcoma 10.0
11 aneurysmal bone cysts 10.0
12 adult brain stem glioma 10.0 IDH2 IDH1
13 brain stem glioma 10.0 IDH2 IDH1
14 cytogenetically normal acute myeloid leukemia 10.0 IDH2 IDH1
15 intracranial chondrosarcoma 10.0 IDH2 IDH1
16 periosteal chondrosarcoma 10.0 IDH2 IDH1
17 adult oligodendroglioma 10.0 IDH2 IDH1
18 oligodendroglioma 10.0 IDH2 IDH1
19 childhood oligodendroglioma 10.0 IDH2 IDH1
20 gemistocytic astrocytoma 10.0 IDH2 IDH1
21 adult astrocytic tumour 10.0 IDH2 IDH1
22 mixed oligodendroglioma-astrocytoma 10.0 IDH2 IDH1
23 mixed glioma 10.0 IDH2 IDH1
24 chondroblastic osteosarcoma 10.0 IDH2 IDH1
25 low grade glioma 10.0 IDH2 IDH1
26 d-2-hydroxyglutaric aciduria 1 10.0 IDH2 IDH1
27 2-hydroxyglutaric aciduria 10.0 IDH2 IDH1
28 l-2-hydroxyglutaric aciduria 10.0 IDH2 IDH1
29 diffuse astrocytoma 9.9 IDH2 IDH1
30 fibroma 9.9
31 goiter 9.9
32 paronychia 9.9
33 malignant fibrous histiocytoma 9.9
34 fibrous histiocytoma 9.9
35 childhood acute myeloid leukemia 9.9 IDH2 IDH1
36 brain glioma 9.9 IDH2 IDH1
37 bile duct adenocarcinoma 9.9 IDH2 IDH1
38 giant cell glioblastoma 9.9 IDH2 IDH1
39 bone sarcoma 9.9 IDH2 IDH1
40 intrahepatic cholangiocarcinoma 9.9 IDH2 IDH1
41 cholangiocarcinoma 9.9 IDH2 IDH1
42 adult hepatocellular carcinoma 9.9 IDH2 IDH1
43 glioma susceptibility 1 9.9 IDH2 IDH1
44 li-fraumeni syndrome 9.9 IDH2 IDH1
45 biliary tract disease 9.9 IDH2 IDH1
46 anaplastic astrocytoma 9.9 IDH2 IDH1
47 plasma cell neoplasm 9.9 IDH2 IDH1
48 spinal disease 9.9 IDH2 IDH1
49 central nervous system cancer 9.9 IDH2 IDH1
50 gliosarcoma 9.8 IDH2 IDH1

Graphical network of the top 20 diseases related to Enchondroma:



Diseases related to Enchondroma

Symptoms & Phenotypes for Enchondroma

UMLS symptoms related to Enchondroma:


pain

Drugs & Therapeutics for Enchondroma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Low Grade Chondrosarcoma Versus Enchondroma: Challenges in Diagnosis and Management Completed NCT02996747

Search NIH Clinical Center for Enchondroma

Genetic Tests for Enchondroma

Anatomical Context for Enchondroma

MalaCards organs/tissues related to Enchondroma:

40
Bone, Brain, Lung, Bone Marrow, Myeloid, Pituitary, Smooth Muscle

Publications for Enchondroma

Articles related to Enchondroma:

(show top 50) (show all 671)
# Title Authors PMID Year
1
The changing face of central chondrosarcoma of bone. One UK-based orthopaedic oncology unit's experience of 33 years referrals. 61
33747783 2021
2
Chondrogenic Bone Tumors: The Importance of Imaging Characteristics. 61
33152784 2021
3
Early Surgical Treatment of Both Tumor and Fracture in Patients With Enchondroma of the Hand Combined With Pathologic Fracture. 61
33661226 2021
4
Curettage and cryosurgery for enchondroma and atypical cartilaginous tumors of the long bones: Oncological results of a large series. 61
33713465 2021
5
Enchondromatosis and Growth Plate Development. 61
33306166 2021
6
Chondrosarcoma. 61
33595238 2021
7
Targeted Ptpn11 deletion in mice reveals the essential role of SHP2 in osteoblast differentiation and skeletal homeostasis. 61
33500396 2021
8
MRI features of low-grade and high-grade chondrosarcoma in enchondromatosis. 61
33484272 2021
9
Imaging Features of Primary Tumors of the Hand. 61
32811403 2021
10
Fine-Needle Aspiration Cytology in Preoperative Diagnosis of Bone Lesions: A Three-Year Study in a Tertiary Care Hospital. 61
33181515 2021
11
Solitary enchondroma in a metatarsal bone, an incidental discovery. 61
33373918 2021
12
Mallet Finger Fracture through Enchondroma of the Distal Phalanx. 61
33408449 2020
13
A painful lump on a teenager's toe is a benign enchondroma. 61
33220738 2020
14
Familial Giant Enchondroma of Thoracic Spine: A Rare Manifestation of a Rare Disease. 61
33342888 2020
15
Bone Scans Have Little Utility in the Evaluation of Well-Differentiated Cartilaginous Lesions of the Humerus. 61
32882054 2020
16
Solitary enchondromas-diagnosis and surveillance : Danish guidelines. 61
32322923 2020
17
Incidental long bone cartilage lesions: is any further imaging workup needed? 61
33169221 2020
18
Solitary long-bone epiphyseal lesions in children: radiologic-pathological correlation and epidemiology. 61
32638051 2020
19
Genomic Profiling of Low-grade Intramedullary Cartilage Tumors Can Distinguish Enchondroma From Chondrosarcoma. 61
33239505 2020
20
Beyond the Influence of IDH Mutations: Exploring Epigenetic Vulnerabilities in Chondrosarcoma. 61
33266275 2020
21
Co-existence of lung carcinoma metastasis and enchondroma in the femur of a patient with Ollier disease. 61
33047157 2020
22
The distribution of chondromas: Why the hand? 61
32759011 2020
23
The minimally invasive endoscopic technique for the treatment of symptomatic benign bone lesions: Preliminary results from a retrospective study. 61
32817813 2020
24
Corrigendum to "Enchondroma protuberans of the hand: A case report" [Radiology Case Reports 15 (2020) 943-946]. 61
32774583 2020
25
Primary total shoulder arthroplasty in the setting of a benign enchondroma. 61
32815810 2020
26
Total Knee Arthroplasty and Atypical Cartilaginous Tumor/Enchondroma of the Distal Femur. 61
32743034 2020
27
An imaging protocol for the management of central cartilage tumours of the proximal fibula. 61
32665062 2020
28
Increased femoral anteversion related to infratrochanteric femoral torsion is associated with ACL rupture. 61
32030504 2020
29
Are the tubular bones of the hand really the commonest site for an enchondroma? 61
32183998 2020
30
Reconstruction of hand in aggressive benign bone tumors by mini JESS fixator. 61
32684713 2020
31
Enchondroma protuberans of the hand: A case report. 61
32405332 2020
32
FDP Avulsion Injury Due to Enchondroma: A Unique Surgical Approach. 61
32312209 2020
33
Bone Tumors: Benign Bone Tumors. 61
32573182 2020
34
Quantitative SPECT/CT for differentiating between enchondroma and grade I chondrosarcoma. 61
32601314 2020
35
Pathologic mallet fracture of distal phalanx enchondroma: A case report. 61
32481387 2020
36
Extended Curettage and Fibular Grafting in Enchondroma of the Acromion. 61
32399362 2020
37
Surgical Treatment of Solitary Enchondromas of the Hand. 61
32373401 2020
38
The role of Thallium-201 scintigraphy and Tc-99m pentavalent dimercaptosuccinic acid in diagnosis and grading of chondrosarcoma. 61
32062570 2020
39
[Radiomics models based on non-enhanced MRI can differentiate chondrosarcoma from enchondroma]. 61
32895139 2020
40
A bent needle tip during irrigation for enchondroma of the distal phalanx: a new curettage tool. 61
31854252 2020
41
Contribution of Raman Spectroscopy to Diagnosis and Grading of Chondrogenic Tumors. 61
32034187 2020
42
Giant enchondroma recurrence of the proximal phalanx of the fifth finger: a case report. 61
32550970 2020
43
Differential diagnosis and treatment of enchondromas and atypical cartilaginous tumours of the pelvis: analysis of 21 patients. 61
31502011 2020
44
Surgical management of an enchondroma of the proximal phalanx of the foot: An illustrative case report. 61
32821391 2020
45
Diagnostic role of neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio in patients with enchondroma and low-grade chondrosarcoma. 61
32584727 2020
46
[Chondrosarcoma of the hand arising from multiple enchondromas: a case report]. 61
31363795 2020
47
Differential Diagnosis of Cartilaginous Lesions of Bone. 61
31877083 2020
48
Battle Against Musculoskeletal Tumors: Descriptive Data of Military Hospital Experience. 61
32269986 2020
49
Metabolic profiling of serum in patients with cartilage tumours using 1 H-NMR spectroscopy: A pilot study. 61
31323132 2020
50
The incidence and outcome of chondral tumours as incidental findings on investigation of shoulder pathology. 61
31422474 2020

Variations for Enchondroma

Expression for Enchondroma

Search GEO for disease gene expression data for Enchondroma.

Pathways for Enchondroma

GO Terms for Enchondroma

Cellular components related to Enchondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxisome GO:0005777 8.62 IDH2 IDH1

Biological processes related to Enchondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tricarboxylic acid cycle GO:0006099 9.32 IDH2 IDH1
2 2-oxoglutarate metabolic process GO:0006103 9.26 IDH2 IDH1
3 NADP metabolic process GO:0006739 9.16 IDH2 IDH1
4 isocitrate metabolic process GO:0006102 8.96 IDH2 IDH1
5 glyoxylate cycle GO:0006097 8.62 IDH2 IDH1

Molecular functions related to Enchondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 magnesium ion binding GO:0000287 9.32 IDH2 IDH1
2 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.26 IDH2 IDH1
3 NAD binding GO:0051287 9.16 IDH2 IDH1
4 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH2 IDH1
5 isocitrate dehydrogenase activity GO:0004448 8.62 IDH2 IDH1

Sources for Enchondroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....