Aliases & Classifications for Enchondroma

MalaCards integrated aliases for Enchondroma:

Name: Enchondroma 54 74

Classifications:



External Ids:

UMLS 74 C1704356

Summaries for Enchondroma

MalaCards based summary : Enchondroma is related to enchondromatosis, multiple, ollier type and multiple enchondromatosis, maffucci type, and has symptoms including pain An important gene associated with Enchondroma is IDH1 (Isocitrate Dehydrogenase (NADP(+)) 1, Cytosolic), and among its related pathways/superpathways are Carbon metabolism and Glutathione metabolism. The drugs Cisplatin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and breast.

Wikipedia : 77 An enchondroma is a cartilage cyst found in the bone marrow. Typically, enchondroma is discovered on an... more...

Related Diseases for Enchondroma

Diseases related to Enchondroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 enchondromatosis, multiple, ollier type 32.8 IDH1 IDH2
2 multiple enchondromatosis, maffucci type 32.8 IDH1 IDH2
3 chondrosarcoma 31.1 IDH1 IDH2
4 undifferentiated pleomorphic sarcoma 30.0 IDH1 IDH2
5 spindle cell hemangioma 29.8 IDH1 IDH2
6 metachondromatosis 11.8
7 chondroma 11.5
8 spondyloenchondrodysplasia 11.1
9 osteochondroma 10.2
10 breast cancer 10.0
11 hemangioma 10.0
12 malignant fibroxanthoma 10.0
13 juxtacortical chondroma 10.0
14 chondroblastoma 10.0
15 histiocytoma 10.0
16 fibrous histiocytoma 10.0
17 interval angle-closure glaucoma 10.0 IDH1 IDH2
18 adult oligodendroglioma 10.0 IDH1 IDH2
19 oligodendroglioma 10.0 IDH1 IDH2
20 intracranial chondrosarcoma 10.0 IDH1 IDH2
21 cytogenetically normal acute myeloid leukemia 10.0 IDH1 IDH2
22 chondroblastic osteosarcoma 10.0 IDH1 IDH2
23 intraductal papilloma 10.0 IDH1 IDH2
24 pilocytic astrocytoma of cerebellum 10.0 IDH1 IDH2
25 periosteal chondrosarcoma 10.0 IDH1 IDH2
26 glioma susceptibility 1 10.0 IDH1 IDH2
27 adult astrocytic tumour 10.0 IDH1 IDH2
28 fibrillary astrocytoma 10.0 IDH1 IDH2
29 diffuse infiltrative lymphocytosis syndrome 10.0 IDH1 IDH2
30 drug-induced mental disorder 10.0 IDH1 IDH2
31 drug psychosis 10.0 IDH1 IDH2
32 2-hydroxyglutaric aciduria 10.0 IDH1 IDH2
33 d-2-hydroxyglutaric aciduria 1 10.0 IDH1 IDH2
34 bile duct adenocarcinoma 9.9 IDH1 IDH2
35 brain stem glioma 9.9 IDH1 IDH2
36 supratentorial cancer 9.9 IDH1 IDH2
37 cerebrum cancer 9.9 IDH1 IDH2
38 central nervous system cancer 9.9 IDH1 IDH2
39 camurati-engelmann disease 9.9
40 fibrodysplasia ossificans progressiva 9.9
41 fibromuscular dysplasia 9.9
42 osteogenesis imperfecta, type i 9.9
43 brittle bone disorder 9.9
44 aneurysmal bone cysts 9.9
45 fibroma 9.9
46 osteopoikilosis 9.9
47 patulous eustachian tube 9.9
48 mucocele of salivary gland 9.9
49 paronychia 9.9
50 coccidioidomycosis 9.9

Graphical network of the top 20 diseases related to Enchondroma:



Diseases related to Enchondroma

Symptoms & Phenotypes for Enchondroma

UMLS symptoms related to Enchondroma:


pain

Drugs & Therapeutics for Enchondroma

Drugs for Enchondroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved 15663-27-1 2767 441203 84093
2
Methotrexate Approved 1959-05-2, 59-05-2 126941
3
Doxorubicin Approved, Investigational 23214-92-8 31703
4
Doxil Approved June 1999 31703

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Low Grade Chondrosarcoma Versus Enchondroma Completed NCT02996747
2 Proteomics Research of Osteosarcoma Recruiting NCT03932058 Chemotherapy

Search NIH Clinical Center for Enchondroma

Genetic Tests for Enchondroma

Anatomical Context for Enchondroma

MalaCards organs/tissues related to Enchondroma:

42
Bone, Bone Marrow, Breast, Pituitary, Thyroid, Brain, Cerebellum

Publications for Enchondroma

Articles related to Enchondroma:

(show top 50) (show all 239)
# Title Authors Year
1
Enchondroma of Tibia as Potential False-positive Finding on 68Ga-DOTATOC PET/CT Scan. ( 30371598 )
2019
2
Coexistence of giant cell tumor of tendon sheath and enchondroma in the middle phalanx of the little finger mimicking a malignant tumor: A case report. ( 30675262 )
2019
3
Fibroma of tendon sheath embedded in carpal bones mimicking carpal enchondroma: A case report. ( 31008967 )
2019
4
Inactivation of Lkb1 in postnatal chondrocytes leads to epiphyseal growth-plate abnormalities and promotes enchondroma-like formation. ( 31091421 )
2019
5
Intracellular cholesterol biosynthesis in enchondroma and chondrosarcoma. ( 31039139 )
2019
6
How to Diagnose Enchondroma, Bone Infarct, and Chondrosarcoma. ( 29724496 )
2018
7
A case of enchondroma from Carolingian necropolis of St. Pere De Terrassa (Spain): An insight into the archaeological record. ( 29496221 )
2018
8
Enchondroma with Osteopoikilosis Coexisting Together -A Rare Clinical and Radiological Case Report. ( 29854696 )
2018
9
Ultrasound manifestations of enchondroma protuberans: Two case reports. ( 29924025 )
2018
10
Enchondroma Protuberans of the Transverse Process of D8 Vertebra Extending to the 7th and 8th Ribs: A Rare Case Report. ( 30280082 )
2018
11
Isolated enchondroma of the atlas. ( 30783356 )
2018
12
Hand enchondroma - complete evaluation and rehabilitation. ( 30845288 )
2018
13
Another gouty tophus? The many faces of the enchondroma. ( 28242213 )
2018
14
Diagnostic value of MRI-based 3D texture analysis for tissue characterisation and discrimination of low-grade chondrosarcoma from enchondroma: a pilot study. ( 28884356 )
2018
15
Large enchondroma of the thoracic spine: a rare case report and review of the literature. ( 28407736 )
2017
16
Risk factors for local recurrence from atypical cartilaginous tumour and enchondroma of the long bones. ( 28501961 )
2017
17
Curettage Using Soft-wire for Enchondroma in the Hand: A Technical Note. ( 29051884 )
2017
18
Reverse total shoulder arthroplasty in a patient with osteogenesis imperfecta type I complicated by a proximal humeral enchondroma: a case report and review of the literature. ( 30675552 )
2017
19
Treatment of hand enchondroma with injectable calcium phosphate cement: a series of eight cases. ( 27942915 )
2017
20
Use of MicroRNA biomarkers to distinguish enchondroma from low-grade chondrosarcoma. ( 27267924 )
2017
21
Expression of insulin-like growth factor II mRNA binding protein 3 (IMP3) in enchondroma and chondrosarcoma. ( 26948096 )
2016
22
Enchondroma versus Chondrosarcoma in Long Bones of Appendicular Skeleton: Clinical and Radiological Criteria-A Follow-Up. ( 27034667 )
2016
23
Enchondroma Protuberans of the Ulna in a Pediatric Patient: A Case Report. ( 29252631 )
2016
24
Radiologic follow-up of untreated enchondroma and atypical cartilaginous tumors in the long bones. ( 27696436 )
2016
25
Enchondroma in the distal phalanx of the finger: An observational study of 34 cases in a single institution. ( 27661057 )
2016
26
Pathological Avulsion Fracture of the Flexor Digitorum Profundus after Enchondroma-Case Report. ( 27625544 )
2016
27
Primary intra-osseous myoepithelioma of phalanx mimicking an enchondroma. ( 27524490 )
2016
28
Recurrence of Enchondroma in a Middle Finger after Curettage and Back-filling with Calcium Phosphate Bone Cement: a Case Report. ( 27492208 )
2016
29
Enchondroma of the Hand: Evaluation and Management. ( 27454024 )
2016
30
Predicting Fracture Risk for Enchondroma of the Hand. ( 27390564 )
2016
31
Arthroscopic treatment for femoral neck enchondroma: case report. ( 27011868 )
2015
32
Giant cell reparative granuloma of the hallux following enchondroma. ( 26985281 )
2015
33
A Rare Occurrence of Enchondroma in Neck of Femur in an Adult Female: A Case Report. ( 26816956 )
2015
34
Enchondroma of the cervical spine in young woman: A rare case report. ( 26425170 )
2015
35
Enchondroma of the Skull Base in a Case of Ollier's Syndrome. ( 26351491 )
2015
36
The surgical management of hand enchondroma without postcurettage void augmentation: authors' experience and a systematic review. ( 26330779 )
2015
37
Enchondroma of the scaphoid: a case report. ( 26327970 )
2015
38
Avulsion of flexor digitorum profundus secondary to enchondroma of the distal phalanx. Case report and literature review. ( 26204827 )
2015
39
Recurrent Metacarpal Enchondroma Treated With Strut Allograft: 14-year Follow-up. ( 26186330 )
2015
40
Atypical Localization of Enchondroma in the Calcaneus. ( 26146974 )
2015
41
Enchondroma of the Distal Phalanx. ( 26129760 )
2015
42
Enchondroma of the Foot. ( 26024560 )
2015
43
Endoscopic curettage and bone grafting of the enchondroma of the proximal phalanx of the great toe. ( 25937415 )
2015
44
Atypical Localization of Enchondroma in the Calcaneus. ( 25867903 )
2015
45
Local review of treatment of hand enchondroma (artificial bone substitute versus autologous bone graft) in a tertiary referral centre: 13 years' experience. ( 25810024 )
2015
46
Phenolization and coralline hydroxyapatite grafting following meticulous curettage for the treatment of enchondroma of the hand. A case series of 82 patients with 5-year follow-up. ( 25767429 )
2015
47
Treatment of a fractured juxta-articular enchondroma of the middle phalanx with a Suzuki external fixator: a case report. ( 25706150 )
2015
48
Osseous tumor of the hand: finger enchondroma. ( 25671055 )
2015
49
Current management of hand enchondroma: a review. ( 25609298 )
2015
50
Enchondroma of clivus: appearance on 18F-FDG PET-CT in contrast with MRI. ( 25489953 )
2015

Variations for Enchondroma

Expression for Enchondroma

Search GEO for disease gene expression data for Enchondroma.

Pathways for Enchondroma

GO Terms for Enchondroma

Cellular components related to Enchondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxisome GO:0005777 8.62 IDH1 IDH2

Biological processes related to Enchondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tricarboxylic acid cycle GO:0006099 9.32 IDH1 IDH2
2 2-oxoglutarate metabolic process GO:0006103 9.26 IDH1 IDH2
3 NADP metabolic process GO:0006739 9.16 IDH1 IDH2
4 isocitrate metabolic process GO:0006102 8.96 IDH1 IDH2
5 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Enchondroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 magnesium ion binding GO:0000287 9.32 IDH1 IDH2
2 NAD binding GO:0051287 9.26 IDH1 IDH2
3 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 IDH1 IDH2
4 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
5 isocitrate dehydrogenase activity GO:0004448 8.62 IDH1 IDH2

Sources for Enchondroma

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70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
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75 UMLS via Orphanet
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