Aliases & Classifications for End Stage Renal Failure

MalaCards integrated aliases for End Stage Renal Failure:

Name: End Stage Renal Failure 12 15
End Stage Renal Disease 12 15
Chronic Kidney Disease Stage 5 71
Kidney Failure, Chronic 71


External Ids:

Disease Ontology 12 DOID:783
ICD10 32 N18.5
UMLS 71 C0022661 C2316810

Summaries for End Stage Renal Failure

MalaCards based summary : End Stage Renal Failure, also known as end stage renal disease, is related to frasier syndrome and nephrotic syndrome, type 1, and has symptoms including cloudy (hemodialysis) (peritoneal) dialysis effluent An important gene associated with End Stage Renal Failure is PKD1 (Polycystin 1, Transient Receptor Potential Channel Interacting), and among its related pathways/superpathways are Development Angiotensin activation of ERK and Pathways in cancer. The drugs Capsaicin and Simvastatin have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney... more...

Related Diseases for End Stage Renal Failure

Diseases related to End Stage Renal Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1309)
# Related Disease Score Top Affiliating Genes
1 frasier syndrome 33.7 WT1 PLCE1 NPHS2 NPHS1
2 nephrotic syndrome, type 1 33.6 WT1 NPHS2 NPHS1
3 nephrotic syndrome, type 2 33.5 PLCE1 NPHS2 NPHS1
4 alport syndrome 33.5 PKD1 MYH9 COL4A5 ALB
5 genetic steroid-resistant nephrotic syndrome 33.2 WT1 PLCE1 NPHS2 NPHS1
6 pierson syndrome 33.0 WT1 PLCE1 NPHS2 NPHS1 COL4A5
7 microvascular complications of diabetes 3 32.0 NPHS1 ALB AGTR1 ACE
8 peritonitis 31.8 TNF IL6 CRP ALB
9 secondary hyperparathyroidism 31.7 PTH EPO ALB
10 peripheral vascular disease 31.7 IL6 EPO CRP ALB ACE
11 limb ischemia 31.7 TNF IL6 ACE
12 glomerulonephritis 31.7 NPHS2 NPHS1 MYH9 FN1 COL4A5 ALB
13 acute kidney failure 31.6 UMOD CST3 ALB
14 amyloidosis 31.6 TNF IL6 CST3 CRP ALB
15 nutritional deficiency disease 31.6 IL6 EPO CRP ALB
16 uremia 31.6 TNF PTH IL6 EPO CRP ALB
17 pyelonephritis 31.6 UMOD TNF IL6 CRP ALB ACE
18 iga glomerulonephritis 31.6 NPHS2 NPHS1 ALB AGTR1 ACE
19 nephrotic syndrome 31.5 WT1 PLCE1 NPHS2 NPHS1 ALB ACE
20 viral hepatitis 31.5 TNF IL6 CRP ALB
21 malignant hypertension 31.5 AGTR1 AGT ACE
22 chronic pyelonephritis 31.5 UMOD ALB ACE
23 acute pancreatitis 31.5 TNF IL6 CRP ALB
24 acute myocardial infarction 31.5 IL6 FN1 CST3 CRP AGTR1 ACE
25 intermediate coronary syndrome 31.4 IL6 CRP ALB ACE
26 peripheral artery disease 31.4 TNF IL6 CST3 CRP ACE
27 calciphylaxis 31.4 PTH FN1 EPO ALB
28 lipoid nephrosis 31.4 WT1 NPHS2 NPHS1 ALB
29 cardiac tamponade 31.4 CRP ALB ACE
30 interstitial nephritis 31.4 UMOD CRP ALB AGTR1 AGT ACE
31 polycystic kidney disease 31.4 PKD1 EPO CST3 ALB AGTR1 AGT
32 kidney disease 31.3 WT1 UMOD TNF PTH PKD1 NPHS2
33 vascular disease 31.3 TNF PTH IL6 FN1 EPO CST3
34 uremic pruritus 31.3 IL6 CRP
35 angina pectoris 31.3 IL6 CRP ACE
36 renovascular hypertension 31.3 PKD1 AGTR1 ACE
37 glomerular disease 31.3 NPHS2 NPHS1 COL4A5 ALB ACE
38 fabry disease 31.3 UMOD TNF IL6 CST3 CRP
39 hyperphosphatemia 31.3 PTH CRP ALB
40 purpura 31.3 TNF IL6 CRP ACE
41 nephrosclerosis 31.3 TNF NPHS2 NPHS1 AGTR1 ACE
42 microvascular complications of diabetes 5 31.3 ALB AGTR1 AGT ACE
43 lung disease 31.3 TNF IL6 FN1 CRP ALB ACE
44 arteriosclerosis 31.3 IL6 CST3 CRP ACE
45 pulmonary tuberculosis 31.3 TNF IL6 CRP ALB
46 aortic aneurysm, familial abdominal, 1 31.3 IL6 CST3 CRP ACE
47 denys-drash syndrome 31.3 WT1 PLCE1 NPHS2 NPHS1
48 cystitis 31.3 UMOD TNF IL6 CST3 CRP
49 obstructive nephropathy 31.3 ALB AGT ACE
50 myeloma, multiple 31.3 TNF PTH IL6 FN1 EPO CRP

Graphical network of the top 20 diseases related to End Stage Renal Failure:

Diseases related to End Stage Renal Failure

Symptoms & Phenotypes for End Stage Renal Failure

UMLS symptoms related to End Stage Renal Failure:

cloudy (hemodialysis) (peritoneal) dialysis effluent

MGI Mouse Phenotypes related to End Stage Renal Failure:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.45 ACE AGT AGTR1 ALB COL4A5 CRP
2 homeostasis/metabolism MP:0005376 10.38 ACE AGT AGTR1 ALB COL4A5 CRP
3 growth/size/body region MP:0005378 10.27 ACE AGT AGTR1 FN1 GATA3 IL6
4 immune system MP:0005387 10.27 ACE AGT AGTR1 ALB COL4A5 CRP
5 hematopoietic system MP:0005397 10.21 ACE AGTR1 COL4A5 EPO FN1 GATA3
6 mortality/aging MP:0010768 10.19 ACE AGT AGTR1 ALB COL4A5 CST3
7 adipose tissue MP:0005375 10.15 ACE AGT AGTR1 COL4A5 GATA3 IL6
8 liver/biliary system MP:0005370 9.97 ACE AGT ALB EPO FN1 IL6
9 muscle MP:0005369 9.9 AGT ALB CST3 EPO FN1 GATA3
10 neoplasm MP:0002006 9.61 ACE ALB CST3 FN1 IL6 PKD1
11 renal/urinary system MP:0005367 9.44 ACE AGT AGTR1 ALB COL4A5 GATA3

Drugs & Therapeutics for End Stage Renal Failure

Drugs for End Stage Renal Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 690)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Capsaicin Approved Phase 4 404-86-4 1548943
Simvastatin Approved Phase 4 79902-63-9 54454
Eplerenone Approved Phase 4 107724-20-9 150310 443872
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
Digoxin Approved Phase 4 20830-75-5 30322 2724385
Peginterferon alfa-2b Approved Phase 4 215647-85-1, 99210-65-8
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
Ezetimibe Approved Phase 4 163222-33-1 150311
Hydroxychloroquine Approved Phase 4 118-42-3 3652
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
Nadroparin Approved, Investigational Phase 4
Methyldopa Approved Phase 4 555-30-6 38853
Glimepiride Approved Phase 4 93479-97-1 3476
Ticlopidine Approved Phase 4 55142-85-3 5472
Telavancin Approved Phase 4 372151-71-8
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
Argatroban Approved, Investigational Phase 4 74863-84-6 152951
Dolutegravir Approved Phase 4 1051375-16-6 54726191
Peginterferon alfa-2a Approved, Investigational Phase 4 198153-51-4 5360545
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
Liraglutide Approved Phase 4 204656-20-2 44147092
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198
Ramipril Approved Phase 4 87333-19-5 5362129
leucovorin Approved Phase 4 58-05-9 6006 143
Ribavirin Approved Phase 4 36791-04-5 37542
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
Donepezil Approved Phase 4 120014-06-4 3152
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
Everolimus Approved Phase 4 159351-69-6 6442177 70789204
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
Pantoprazole Approved Phase 4 102625-70-7 4679
Insulin aspart Approved Phase 4 116094-23-6 16132418
37 Taurolidine Approved, Investigational Phase 4 19388-87-5
Enoxaparin Approved Phase 4 9005-49-6 772
Remifentanil Approved Phase 4 132875-61-7 60815
Desflurane Approved Phase 4 57041-67-5 42113
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715
Bacitracin Approved, Vet_approved Phase 4 1405-87-4 439542 10909430
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
Deflazacort Approved, Investigational Phase 4 14484-47-0
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
Colchicine Approved Phase 4 64-86-8 6167 2833
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
Nifedipine Approved Phase 4 21829-25-4 4485
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119

Interventional clinical trials:

(show top 50) (show all 2362)
# Name Status NCT ID Phase Drugs
1 A Prospective Randomized, Double-Blind Parallel Group Trial To Assess The Efficacy And Safety Of Intravenous Dextrose 5% Solution Compare With Normal Saline (Standard Care) In Rinsing During Haemodialysis In Subjects With End Stage Renal Failure (ESRF) With Respect To Systolic Blood Pressure Control Over 3 Months Period. Unknown status NCT02590081 Phase 4 Dextrose 5%;normal saline
2 Effects of On-Line Hemodiafiltration(HDF) on Endothelial Dysfunction in Chronic Hemodialysis Patients Unknown status NCT00532597 Phase 4
3 Simvastatin Effect on Endothelium Dependent Venodilation in Chronic Renal Failure Patients Treated by Peritoneal Dialysis Unknown status NCT00291863 Phase 4 Simvastatin
4 The Role of Qutenza (Topical Capsaicin 8%) in Treating Neuropathic Pain From Critical Ischaemia in Patients With End-stage Renal Failure Unknown status NCT01704339 Phase 4 QUTENZA
5 Inspiratory Muscle Training in Patients With End Stage Renal Failure: a Randomized Controlled Trial Unknown status NCT01347775 Phase 4
6 The Association Between Body Composition and Biomarkers in Hemodialysis Patients Unknown status NCT01103167 Phase 4
7 The Effects of Acetylcysteine on Alleviating Damage of Oxidative Stress in Hemodialysis Patients Unknown status NCT00247507 Phase 4 acetylcysteine
8 A comParison on Platelet Resistance With Ticagrelor or Standard-Dose Clopidogrel Study Among SeVerE Chronic Kidney Disease/ End-Stage-Renal-Disease Patients With Recent Acute Coronary Syndrome. Unknown status NCT02459288 Phase 4 Clopidogrel first;Ticagrelor first
9 Marinobufagenin as a Target for DIGIBIND in Hypertensive Patients With End-stage Renal Disease Unknown status NCT00852787 Phase 4 Digoxin immune fab;Placebo
10 A Pilot Study to Treat Patients With Chronic HCV Genotype 1 and ESRD Receiving Hemodialysis and Naïve to Prior HCV Therapy With Peginterferon Alfa-2b, the Maximally Tolerated Ribavirin Dose and Boceprevir Unknown status NCT01731301 Phase 4 Ribavirin;Peginterferon;Boceprevir
11 The Effect of Ferric Citrate on Inflammation and Lipid Levels in Patients on Hemodialysis Unknown status NCT02661295 Phase 4 Ferric Citrate
12 Calcineurin Inhibitor Minimisation in Renal Transplant Recipients With Stable Allograft Function: A Prospective Randomised Controlled Trial Unknown status NCT00541814 Phase 4 Cyclosporine
13 A Phase-IV Study Comparing Standard Release Tacrolimus (Prograf) vs Prolonged-release Tacrolimus (Advagraf) Monotherapy as Maintenance Immunosuppression After Induction With Alemtuzumab in Kidney Transplantation Unknown status NCT00807144 Phase 4 Tacrolimus (Kidney transplant maintenance immunosuppression);Kidney transplant maintenance immunosuppression
14 The Effect of Far Infrared (FIR) Therapy on Access Flow of Arteriovenous (AV) Fistula, Echocardiographic Parameters and Endothelial Function in Patients With End Stage Renal Disease Unknown status NCT01138254 Phase 4
15 Comparison of Onset of Action Between 2% Lidocaine Plus 0.5% Bupivacaine and 0.5% Bupivacaine in Brachial Plexus Anesthesia for Creation of Arteriovenous Fistula in ESRD Patient Unknown status NCT00993746 Phase 4 Bupivacaine plus lidocaine;Bupivacaine 30 ml
16 A Comparative Study of Dexmedetomidine and Propofol As Sole Sedative Agent for Patients With End-Stage Renal Disease Undergoing Arteriovenous Fistula Surgery Unknown status NCT02447796 Phase 4 Propofol;Dexmedetomidine
17 Hemocontrol's Effectiveness in a RAndomized Controlled Trial on the Reduction of Cardiovascular Long-term EventS Unknown status NCT01515878 Phase 4
18 The Impact of Conventional Hemodialysis, High Flux Hemodialysis and Hemodiafiltration on Adiponectin, Vascular Function and Clinical Prognosis Unknown status NCT00155363 Phase 4
19 Renoprotection by Combining Pentoxifylline and Angiotensin Blockade in Chronic Kidney Disease Unknown status NCT01377285 Phase 4 ARB;Pentoxifylline;Placebo (for Pentoxifylline)
20 The Determinants of the Effectiveness of the Use of Furosemide in Patients on Dialysis Unknown status NCT01815892 Phase 4 Withdrawal of furosemide;furosemide administration
21 The Efficacy and Safety of Niacin on Hyperphosphatemia in End Stage Renal Disease Patients Undergoing Haemodialysis Unknown status NCT03163576 Phase 4 Niacin;Phosphate Binder
22 Clinical Trial, Open, Parallel Groups , Value the Antiproteinuric Effects From Vitamin D Derivatives in Patient With Chronic Kidney Illness and the Lack of Vitamin D Unknown status NCT01442272 Phase 4 Hidroferol®;Paricalcitol: Zemplar®;Habitual medication
23 Renal Toxicity of Iodixanol and Iopromide in Patients With Renal Dysfunction—a Multicentre, Single Blind, Randomized Controlled, Prospective Trial Unknown status NCT01580046 Phase 4 iodixanol;iopromide
24 Protective Mechanisms of Aldosterone Antagonists and Their Effects on Cardiovascular Damage in Chronic Renal Failure: Clinical and Experimental Studies Unknown status NCT00277693 Phase 4 Spironolactone (drug)
25 Effect of Hydration With Sodium Bicarbonate for Long-Term Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing an Emergent Coronary Procedure Unknown status NCT00716001 Phase 4 N-acetylcysteine
26 Upstream Use of Aliskiren in Hypertensive Haemodialysis Patients: Effects on Cardiovascular Outcomes Unknown status NCT01635387 Phase 4 aliskiren
27 Open Randomized Phase IV Study on Intravenous Iron in Anemic Patients With Chronic Kidney Disease Unknown status NCT00204256 Phase 4 Iron sucrose
28 Pulse Wave Velocity, Pulse Wave Morphology and Blocking of the Reninangiotensin System in Patients With Chronic Kidney Disease: An Interventional and Methodological Study Unknown status NCT00235287 Phase 4 Candesartan and enalapril;candesartan and enalapril;candesartan and enalapril;candesartan and enalapril
29 The Effects of AST-120 on Endothelial Dysfunction in Patients With Chronic Kidney Disease Unknown status NCT01157260 Phase 4 Kremezin
30 The Metabolic and Anti-Inflammatory Effects of Combined Ezetimibe and Simvastin Therapy, as Compared to Simvastatin Alone, in Patients With Chronic Proteinuric Nephropathy Unknown status NCT00861731 Phase 4 simvastatin;EZE/simvastatin;EZE/simvastatin
31 NAC in Preventing CIN in CRF Patients Who Need Enhanced CT Scan in ED Unknown status NCT00501475 Phase 4 NAC Bicarbonate
32 Randomized, Open Label, Controlled Clinical Trial of Egg Albumin-Based Protein Supplement Versus Renal Specific Oral Supplement in Hemodialysis Patients Unknown status NCT01981083 Phase 4
33 Phase 4 Study of Medical Therapy Versus Medical Therapy Plus Renal Artery Stenting in Preventing the Progression of Renal Failure in Atherosclerotic Renovascular Disease Unknown status NCT01023373 Phase 4 Medical treatment
34 A Randomized, Open, Controlled, Parallel Group Study of Adding Linagliptin to Control Glycemic Variability and HbA1c in Peritoneal Dialysis Patients With Type 2 Diabetes(PDPD) With Premixed Insulin Therapy Unknown status NCT03320031 Phase 4 Linagliptin;Humalog Mix 75/25
35 The Immunogenicity and Safety of the Seasonal Influenza Vaccine, Formulation 2013-2014, in Chronic Kidney Disease Patients Not on Dialysis Unknown status NCT02105519 Phase 4
36 Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus Unknown status NCT01073501 Phase 4 Pregabalin;Placebo
37 Clinical Impact of Bacteriuria on Chronic Inflammation in Asymptomatic Hemodialysis Patients Unknown status NCT01570556 Phase 4
38 N-Acetylcysteine to Prevent Contrast-Induced Nephropathy in Acute Coronary Syndromes Unknown status NCT00939913 Phase 4 intravenous NAC;Placebo
39 The Effects of Thiazolidinedione on the Diabetic Retinopathy and Nephropathy Unknown status NCT01175486 Phase 4 Actos (Pioglitazone);Acarbose
40 Lithium in Cardiac Surgery Related Acute Kidney Injury: A Pilot Study Unknown status NCT03056248 Phase 4 Placebo oral capsule;Lithium Carbonate
41 Interstitial Fibrosis in Protocol Biopsies of Renal Allografts: A Prospective, Randomised Trial of Sirolimus Versus Cyclosporine.(Fibrasic) Unknown status NCT00493194 Phase 4 sirolimus;cyclosporine;daclizumab
42 Effect of Short-term Synbiotic Treatment on Plasma P-cresol Levels in Hemodialysis Patients Unknown status NCT02311868 Phase 4
43 Phase 4 Study of Mechanisms of Low Protein Diet Supplemented With Ketoanalogs on Reducing Proteinuria and Maintaining Nutritional Status in Type 2 Diabetic Nephropathy Unknown status NCT01300273 Phase 4
44 Providing Intravenous Paricalcitol Treatment to the Sick and Poor Chronic Hemodialysis Patients With Severe Secondary Hyperparathyroidism Resistant to Existing Vitamin D Analogs Unknown status NCT03023748 Phase 4 Intravenous Paricalcitol
45 Effect of Ursodeoxycholic Acid on Peritoneal Function in Patients on Peritoneal Dialysis Unknown status NCT02338635 Phase 4 Ursodeoxycholic Acid
46 A Randomized Prospective Trial of N-acetyl Cystein in Patients With Peritoneal Dialysis Unknown status NCT01111422 Phase 4 N-acetylcysteine
47 Phase 4 Study of Alprostadil Prevent Contrast Induced Nephropathy in Patients Receiving a Cardiac Catheterization Unknown status NCT01722513 Phase 4 Alprostadil ﹠control
48 Hypervolemia and Treatment Guided by Bioimpedance in End Stage Renal Disease Patients in Zonguldak (Prospective Study) Unknown status NCT01468363 Phase 4
49 Peripheral Artery Disease in Patients on Maintenance Hemodialysis: Risk Factors and the Effect of FIR Therapy Unknown status NCT01095549 Phase 4
50 Clinical Trial Technology Development for the Validation of Surrogate Prognostic Markers in Patients With Diabetic Nephropathy Unknown status NCT01673204 Phase 4 Calcitriol;Placebo

Search NIH Clinical Center for End Stage Renal Failure

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Aluminum carbonate
basic aluminum carbonate gel
calcium acetate
Calcium Carbonate
Calcium gluceptate
dihydroxyaluminum sodium carbonate
Ethacrynate Sodium
Ethacrynic Acid
Magnesium Hydroxide

Genetic Tests for End Stage Renal Failure

Anatomical Context for End Stage Renal Failure

MalaCards organs/tissues related to End Stage Renal Failure:

Kidney, Heart, Bone, Liver, Endothelial, Pancreas, Testes

Publications for End Stage Renal Failure

Articles related to End Stage Renal Failure:

(show top 50) (show all 35521)
# Title Authors PMID Year
Coronary artery bypass grafting vs. drug-eluting stent implantation in patients with end-stage renal disease requiring dialysis. 61
31918608 2020
Association between epidermal growth factor (EGF) and EGF receptor gene polymorphisms and end-stage renal disease and acute renal allograft rejection in a Korean population. 61
31906817 2020
Late diagnosis of Lesch-Nyhan disease complicated with end-stage renal disease and tophi burst: a case report. 61
31985336 2020
Long non-coding RNA MALAT1 and microRNA-499a expression profiles in diabetic ESRD patients undergoing dialysis: a preliminary cross-sectional analysis. 61
30270667 2020
Incidence and relative risk of renal replacement therapy in people with and without diabetes between 2002 and 2016 in a German region. 61
31865404 2020
Population Pharmacokinetics of Glecaprevir/Pibrentasvir in HCV-infected Japanese Subjects in Phase 3 CERTAIN-1 and CERTAIN-2 Trials. 61
31515816 2020
Short-term safety and effectiveness of sugammadex for surgical patients with end-stage renal disease: a two-centre retrospective study. 61
31721151 2020
Novel splice site and nonsense variants in INVS cause infantile nephronophthisis. 61
31706999 2020
When is parenteral nutrition indicated in the hospitalized, acutely ill patient? 61
31895227 2020
Zosteriform cutaneous metastases: an unusual presentation of metastatic lung carcinoma. 61
31890214 2020
Spontaneous lumbar artery rupture in a kidney transplant patient: A case report. 61
31908959 2020
Simultaneous determination of bisphenol A and its chlorinated derivatives in human plasma: Development, validation and application of a UHPLC-MS/MS method. 61
31896187 2020
The nephrologist's guide to cannabis and cannabinoids. 61
31972598 2020
Predicting renal disease progression in a large contemporary cohort with type 1 diabetes mellitus. 61
31807796 2020
Diabetic Kidney Disease: Past and Present. 61
31876542 2020
Association between air pollutants and development of chronic kidney disease: A systematic review and meta-analysis. 61
31864998 2020
Polyunsaturated fatty acid food frequency questionnaire validation in people with end stage renal disease on dialysis. 61
30338904 2020
Cardiovascular death and progression to end-stage renal disease after major surgery in elderly patients. 61
32011817 2020
Incidence of end-stage renal disease after heart transplantation and effect of its treatment on survival. 61
32022443 2020
Geographic Differences in Population Health and Expected Organ Supply in the Gulf Coast Region of the United States Compared to Non-Gulf States. 61
32004235 2020
Diagnostic and Risk Factors for Complement Defects in Hypertensive Emergency and Thrombotic Microangiopathy. 61
31865800 2020
Effect of Thyroid Hormones on Kidney Function in Patients after Kidney Transplantation. 61
32034263 2020
Co-culture of human fibroblasts, smooth muscle and endothelial cells promotes osteopontin induction in hypoxia. 61
32032472 2020
Outcomes of Infrainguinal Lower Extremity Bypass Are Superior in Kidney Transplant Recipients Than Patients with Dialysis. 61
31349053 2020
Living in one's own world, while life goes on: Patients' experiences prior to a kidney transplantation with a living donor. 61
31769557 2020
Predictive value of circulating coagulation related microRNAs expressions for major adverse cardiac and cerebral event risk in patients undergoing continuous ambulatory peritoneal dialysis: a cohort study. 61
31359371 2020
Latest developments in living kidney donation. 61
31833966 2020
Application of Reticulocyte-Based Estimation of Red Blood Cell Lifespan in Anemia Management of End-Stage Renal Disease Patients. 61
32016602 2020
Intrauterine growth restriction, preterm birth and risk of end-stage renal disease during the first 50 years of life. 61
32040151 2020
Profiles of B-cell subsets in immunologically stable renal allograft recipients and end-stage renal disease patients. 61
31626945 2020
Development and Validation of a New LC-MS/MS Analytical Method for Direct-Acting Antivirals and Its Application in End-Stage Renal Disease Patients. 61
31667795 2020
Lifetime cost-effectiveness analysis of first-line dialysis modalities for patients with end-stage renal disease under peritoneal dialysis first policy. 61
32019528 2020
Functional-structural relationship in large-scale brain networks of patients with end stage renal disease after kidney transplantation: A longitudinal study. 61
31571368 2020
Author Correction: Risk of End-Stage Renal Disease in Psoriatic Patients: Real-World Data from a Nationwide Population-Based Cohort Study. 61
32024918 2020
Successful Treatment of End-stage Renal Disease in a Patient With Chronic Myeloid Leukemia by Kidney Transplantation and Tyrosine Kinase Inhibitors: A Case Report. 61
32029318 2020
Effects of Rikkunshito treatment on renal fibrosis/inflammation and body weight reduction in a unilateral ureteral obstruction model in mice. 61
32024850 2020
Current Anticoagulant Usage Patterns and Determinants in Korean Patients with Nonvalvular Atrial Fibrillation. 61
31997620 2020
Primary causes of kidney disease and mortality in dialysis-dependent children. 61
32020338 2020
Detection and characterization of mosaicism in autosomal dominant polycystic kidney disease. 61
31874800 2020
RAPID-ADPKD (Retrospective epidemiological study of Asia-Pacific patients with rapId Disease progression of Autosomal Dominant Polycystic Kidney Disease): study protocol for a multinational, retrospective cohort study. 61
32034027 2020
Anastomosis of the Common Hepatic Artery and Round Ligament as Portal Vein Arterialization for Hepatic Artery Occlusion After Deceased Donor Liver Transplantation: A Case Report. 61
32033829 2020
GdCl3 attenuates the glomerular sclerosis of streptozotocin (STZ) induced diabetic rats via inhibiting TGF-β/Smads signal pathway. 61
31831259 2020
Connexin-mediated cell communication in the kidney: A potential therapeutic target for future intervention of diabetic kidney disease?: Joan Mott Prize Lecture. 61
31785013 2020
Silencing CCNG1 protects MPC-5 cells from high glucose-induced proliferation-inhibition and apoptosis-promotion via MDM2/p53 signaling pathway. 61
32016904 2020
Risk Factors and Outcomes of Cerebral Stroke in End-Stage Renal Disease Patients Receiving Hemodialysis. 61
32037266 2020
Effects of online hemodiafiltration on anemia and nutritional status in chronic hemodialysis patients. 61
32036641 2020
Pulmonary hypertension in patients with end stage renal disease undergoing hemodialysis. 61
32031094 2020
The variation of motor-related brain structure and its relation to abnormal motor behaviors in end-stage renal disease patients with restless legs syndrome. 61
30259290 2020
Cataract surgery-related complications in patients with end-stage renal disease- a nationwide population-based study in Taiwan. 61
32034272 2020
Effects of Sustained-Release Beraprost in Patients With Primary Glomerular Disease or Nephrosclerosis: CASSIOPEIR Study Results. 61
31119846 2020

Variations for End Stage Renal Failure

ClinVar genetic disease variations for End Stage Renal Failure:

6 ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 PKD1 NM_001009944.3(PKD1):c.2079dup (p.Pro694fs)duplication Pathogenic 374141 rs1057518923 16:2165396-2165397 16:2115395-2115396
2 GATA3 NM_001002295.2(GATA3):c.1051-1G>CSNV Pathogenic 430696 rs112417755 10:8115701-8115701 10:8073738-8073738
3 COL4A4 NM_000092.4(COL4A4):c.4217-15T>CSNV Conflicting interpretations of pathogenicity 255039 rs200926310 2:227877028-227877028 2:227012312-227012312
4 COL4A4 NM_000092.4(COL4A4):c.3055G>C (p.Glu1019Gln)SNV Uncertain significance 374041 rs1057518854 2:227915788-227915788 2:227051072-227051072

Expression for End Stage Renal Failure

Search GEO for disease gene expression data for End Stage Renal Failure.

Pathways for End Stage Renal Failure

Pathways related to End Stage Renal Failure according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
Show member pathways
2 12.61 IL6 FN1 EPO COL4A5 AGTR1 AGT
Show member pathways
Show member pathways
5 11.85 TNF IL6 GATA3 AGT
6 11.68 TNF IL6 GATA3 FN1
Show member pathways
8 11.57 TNF IL6 FN1 COL4A5
9 11.54 AGTR1 AGT ACE
10 11.33 TNF IL6 FN1
12 11.29 TNF PTH IL6
13 11.17 TNF PLCE1 IL6 FN1 COL4A5 AGTR1
14 11.05 TNF IL6 GATA3
15 10.74 TNF IL6 FN1 CRP

GO Terms for End Stage Renal Failure

Cellular components related to End Stage Renal Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.87 PTH PLCE1 PKD1 MYH9 IL6 AGTR1
2 extracellular exosome GO:0070062 9.85 UMOD PKD1 NPHS2 NPHS1 MYH9 FN1
3 extracellular region GO:0005576 9.73 UMOD TNF PTH IL6 FN1 EPO
4 endoplasmic reticulum lumen GO:0005788 9.65 IL6 FN1 CST3 COL4A5 ALB
5 slit diaphragm GO:0036057 9.37 NPHS2 NPHS1
6 extracellular space GO:0005615 9.36 TNF PTH IL6 FN1 EPO CST3

Biological processes related to End Stage Renal Failure according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 10.03 WT1 TNF IL6 GATA3 EPO AGT
2 cellular protein metabolic process GO:0044267 9.94 IL6 FN1 CST3 ALB
3 positive regulation of cytosolic calcium ion concentration GO:0007204 9.85 PLCE1 PKD1 AGTR1 AGT
4 positive regulation of gene expression GO:0010628 9.85 WT1 TNF IL6 GATA3 FN1 CRP
5 regulation of cell growth GO:0001558 9.82 PLCE1 AGTR1 AGT
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.81 TNF IL6 EPO
7 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.77 PLCE1 AGTR1 AGT
8 humoral immune response GO:0006959 9.75 TNF IL6 GATA3
9 negative regulation of fat cell differentiation GO:0045599 9.74 TNF IL6 GATA3
10 response to salt stress GO:0009651 9.65 TNF EPO
11 mesenchymal to epithelial transition GO:0060231 9.63 WT1 GATA3
12 excretion GO:0007588 9.63 UMOD NPHS2 NPHS1
13 glomerular basement membrane development GO:0032836 9.62 WT1 NPHS1
14 glomerulus development GO:0032835 9.62 WT1 PLCE1
15 positive regulation of cholesterol esterification GO:0010873 9.61 AGTR1 AGT
16 neutrophil mediated immunity GO:0002446 9.61 IL6 ACE
17 positive regulation of cytokine production GO:0001819 9.61 TNF GATA3 AGT
18 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.59 IL6 GATA3
19 positive regulation of NAD(P)H oxidase activity GO:0033864 9.58 AGTR1 AGT
20 metanephric ascending thin limb development GO:0072218 9.54 UMOD PKD1
21 regulation of renal sodium excretion GO:0035813 9.52 AGTR1 AGT
22 calcium-independent cell-matrix adhesion GO:0007161 9.51 PKD1 FN1
23 regulation of vasoconstriction GO:0019229 9.5 AGTR1 AGT ACE
24 renin-angiotensin regulation of aldosterone production GO:0002018 9.49 AGTR1 AGT
25 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.48 AGTR1 AGT
26 acute-phase response GO:0006953 9.46 IL6 FN1 EPO CRP
27 negative regulation of lipid storage GO:0010888 9.43 TNF IL6 CRP
28 regulation of renal output by angiotensin GO:0002019 9.4 AGT ACE
29 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.13 AGTR1 AGT ACE
30 kidney development GO:0001822 9.1 WT1 PKD1 GATA3 AGTR1 AGT ACE

Molecular functions related to End Stage Renal Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bradykinin receptor binding GO:0031711 8.62 AGTR1 ACE

Sources for End Stage Renal Failure

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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