Aliases & Classifications for End Stage Renal Failure

MalaCards integrated aliases for End Stage Renal Failure:

Name: End Stage Renal Failure 12 15
End Stage Renal Disease 12 15
Chronic Kidney Disease Stage 5 72
Kidney Failure, Chronic 72

Classifications:



External Ids:

Disease Ontology 12 DOID:783
ICD10 33 N18.5
UMLS 72 C0022661 C2316810

Summaries for End Stage Renal Failure

MalaCards based summary : End Stage Renal Failure, also known as end stage renal disease, is related to frasier syndrome and nephrotic syndrome, type 1, and has symptoms including cloudy (hemodialysis) (peritoneal) dialysis effluent An important gene associated with End Stage Renal Failure is PKD1 (Polycystin 1, Transient Receptor Potential Channel Interacting), and among its related pathways/superpathways are Pathways in cancer and T cell receptor signaling pathway. The drugs Capsaicin and Simvastatin have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and bone, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 75 Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney... more...

Related Diseases for End Stage Renal Failure

Diseases related to End Stage Renal Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1153)
# Related Disease Score Top Affiliating Genes
1 frasier syndrome 33.6 WT1 NPHS2 NPHS1
2 nephrotic syndrome, type 1 33.6 WT1 NPHS2 NPHS1
3 nephrotic syndrome, type 6 33.3 WT1 NPHS2 NPHS1
4 microvascular complications of diabetes 3 31.8 NPHS1 ALB AGT ACE
5 limb ischemia 31.6 TNF IL6 ACE
6 peritonitis 31.5 TNF IL6 CRP ALB
7 peripheral vascular disease 31.4 IL6 CRP ALB ACE
8 uremia 31.4 PTH EPO CRP ALB
9 lipoid nephrosis 31.4 NPHS2 NPHS1 ALB
10 glomerulonephritis 31.3 TGFB1 NPHS2 NPHS1 COL4A5 ALB
11 nephrotic syndrome 31.3 WT1 NPHS2 NPHS1 COQ6 ALB
12 denys-drash syndrome 31.3 WT1 NPHS2 NPHS1
13 intermediate coronary syndrome 31.3 IL6 CRP ACE
14 nutritional deficiency disease 31.3 IL6 EPO CRP ALB
15 calciphylaxis 31.3 PTH EPO ALB
16 angina pectoris 31.1 IL6 CRP ACE
17 renal artery disease 31.1 EPO AGT ACE
18 familial nephrotic syndrome 31.1 WT1 NPHS2 NPHS1
19 urinary tract obstruction 31.1 UMOD TGFB1 ALB
20 acute cystitis 31.1 IL6 CRP ALB
21 hepatic encephalopathy 31.1 TNF IL6 ALB
22 cystitis 31.0 UMOD TNF IL6 CRP
23 carotid stenosis 31.0 TNF CRP ACE
24 nephrosclerosis 31.0 TGFB1 NPHS2 NPHS1 ACE
25 peripheral artery disease 31.0 IL6 CST3 CRP ACE
26 acute kidney tubular necrosis 31.0 UMOD CST3 ALB
27 interstitial nephritis 31.0 UMOD CRP ALB AGT ACE
28 thrombocytosis 31.0 IL6 EPO CRP
29 anuria 31.0 ALB AGT ACE
30 analbuminemia 31.0 NPHS1 EPO CRP ALB
31 silicosis 30.9 TNF TGFB1 ACE
32 apnea, obstructive sleep 30.9 TNF IL6 CRP
33 bone inflammation disease 30.9 TNF IL6 CRP
34 exanthem 30.9 TNF IL6 CRP
35 pyelonephritis 30.9 UMOD TNF IL6 CRP ALB ACE
36 appendicitis 30.9 TNF IL6 CRP ALB
37 purpura 30.8 TNF IL6 CRP
38 endocarditis 30.8 TNF IL6 CRP ALB
39 diffuse mesangial sclerosis 30.8 WT1 TGFB1 NPHS2 NPHS1
40 pulmonary edema 30.8 TNF CRP ACE
41 hepatorenal syndrome 30.8 CST3 ALB ACE
42 sleep apnea 30.8 TNF IL6 CRP ACE
43 renal hypertension 30.8 EPO ALB ACE
44 chlamydia 30.8 TNF IL6 CRP
45 vascular disease 30.8 TNF IL6 CST3 CRP ALB ACE
46 systolic heart failure 30.7 IL6 CST3 CRP ACE
47 obstructive nephropathy 30.7 TGFB1 ALB AGT ACE
48 tuberculous peritonitis 30.7 TNF CRP ALB
49 renal dysplasia 30.7 GATA3 AGT ACE
50 acute pyelonephritis 30.7 IL6 CRP ALB

Graphical network of the top 20 diseases related to End Stage Renal Failure:



Diseases related to End Stage Renal Failure

Symptoms & Phenotypes for End Stage Renal Failure

UMLS symptoms related to End Stage Renal Failure:


cloudy (hemodialysis) (peritoneal) dialysis effluent

MGI Mouse Phenotypes related to End Stage Renal Failure:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.48 ACE AGT ALB COL4A5 COQ6 CRP
2 cardiovascular system MP:0005385 10.46 ACE AGT COL4A5 CRP CST3 EPO
3 growth/size/body region MP:0005378 10.36 ACE AGT COQ6 FN1 GATA3 IL6
4 mortality/aging MP:0010768 10.36 ACE AGT ALB COL4A5 COQ6 CST3
5 cellular MP:0005384 10.33 ALB EPO FN1 GATA3 IL6 MYH9
6 immune system MP:0005387 10.33 ACE AGT COL4A5 CRP EPO FN1
7 hematopoietic system MP:0005397 10.27 ACE COL4A5 EPO FN1 GATA3 IL6
8 adipose tissue MP:0005375 10.22 ACE AGT COL4A5 GATA3 IL6 PKD1
9 embryo MP:0005380 10.19 COQ6 EPO FN1 GATA3 MYH9 PKD1
10 endocrine/exocrine gland MP:0005379 10.18 ACE ALB GATA3 IL6 PKD1 PTH
11 liver/biliary system MP:0005370 10.13 ACE AGT ALB EPO FN1 IL6
12 muscle MP:0005369 10.11 AGT ALB CST3 EPO FN1 GATA3
13 nervous system MP:0003631 10 AGT COQ6 CST3 FN1 GATA3 IL6
14 neoplasm MP:0002006 9.97 ACE ALB CST3 FN1 IL6 PKD1
15 renal/urinary system MP:0005367 9.97 ACE AGT ALB COL4A5 GATA3 IL6
16 reproductive system MP:0005389 9.65 ACE AGT CST3 FN1 GATA3 IL6
17 skeleton MP:0005390 9.28 EPO FN1 GATA3 IL6 PKD1 PTH

Drugs & Therapeutics for End Stage Renal Failure

Drugs for End Stage Renal Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 704)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capsaicin Approved Phase 4 404-86-4 1548943
2
Simvastatin Approved Phase 4 79902-63-9 54454
3
Eplerenone Approved Phase 4 107724-20-9 150310 443872
4
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
5
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
6
Alendronate Approved Phase 4 66376-36-1, 121268-17-5 2088
7
Ezetimibe Approved Phase 4 163222-33-1 150311
8
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
9
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
10
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
11
Nadroparin Approved, Investigational Phase 4
12
Methyldopa Approved Phase 4 555-30-6 38853
13
Glimepiride Approved Phase 4 93479-97-1 3476
14
Fenofibrate Approved Phase 4 49562-28-9 3339
15
Ticlopidine Approved Phase 4 55142-85-3 5472
16
Telavancin Approved Phase 4 372151-71-8
17
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
18
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
19
Argatroban Approved, Investigational Phase 4 74863-84-6 152951
20
Dolutegravir Approved Phase 4 1051375-16-6 54726191
21
Peginterferon alfa-2a Approved, Investigational Phase 4 198153-51-4 5360545
22
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
23
Liraglutide Approved Phase 4 204656-20-2 44147092
24
Enoxaparin Approved Phase 4 9005-49-6 772
25
Ramipril Approved Phase 4 87333-19-5 5362129
26
leucovorin Approved Phase 4 58-05-9 143 6006
27
Sirolimus Approved, Investigational Phase 4 53123-88-9 6436030 5284616 46835353
28
Everolimus Approved Phase 4 159351-69-6 6442177 70789204
29
Ribavirin Approved Phase 4 36791-04-5 37542
30
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
31
Donepezil Approved Phase 4 120014-06-4 3152
32
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
33
Olmesartan Approved, Investigational Phase 4 144689-63-4, 144689-24-7 130881 158781
34
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
35
Pantoprazole Approved Phase 4 102625-70-7 4679
36
Insulin Aspart Approved Phase 4 116094-23-6 16132418
37 Taurolidine Approved, Investigational Phase 4 19388-87-5
38
Desflurane Approved Phase 4 57041-67-5 42113
39
Remifentanil Approved Phase 4 132875-61-7 60815
40
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715
41
Bacitracin Approved, Vet_approved Phase 4 1405-87-4 439542 10909430
42
Deflazacort Approved, Investigational Phase 4 14484-47-0
43
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
44
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
45
Colchicine Approved Phase 4 64-86-8 6167 2833
46
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
47
Nifedipine Approved Phase 4 21829-25-4 4485
48
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
49
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
50
Enalaprilat Approved Phase 4 76420-72-9 6917719

Interventional clinical trials:

(show top 50) (show all 2299)
# Name Status NCT ID Phase Drugs
1 A Prospective Randomized, Double-Blind Parallel Group Trial To Assess The Efficacy And Safety Of Intravenous Dextrose 5% Solution Compare With Normal Saline (Standard Care) In Rinsing During Haemodialysis In Subjects With End Stage Renal Failure (ESRF) With Respect To Systolic Blood Pressure Control Over 3 Months Period. Unknown status NCT02590081 Phase 4 Dextrose 5%;normal saline
2 Effects of On-Line Hemodiafiltration(HDF) on Endothelial Dysfunction in Chronic Hemodialysis Patients Unknown status NCT00532597 Phase 4
3 Simvastatin Effect on Endothelium Dependent Venodilation in Chronic Renal Failure Patients Treated by Peritoneal Dialysis Unknown status NCT00291863 Phase 4 Simvastatin
4 The Role of Qutenza (Topical Capsaicin 8%) in Treating Neuropathic Pain From Critical Ischaemia in Patients With End-stage Renal Failure Unknown status NCT01704339 Phase 4 QUTENZA
5 Inspiratory Muscle Training in Patients With End Stage Renal Failure: a Randomized Controlled Trial Unknown status NCT01347775 Phase 4
6 The Association Between Body Composition and Biomarkers in Hemodialysis Patients Unknown status NCT01103167 Phase 4
7 The Effects of Acetylcysteine on Alleviating Damage of Oxidative Stress in Hemodialysis Patients Unknown status NCT00247507 Phase 4 acetylcysteine
8 Marinobufagenin as a Target for DIGIBIND in Hypertensive Patients With End-stage Renal Disease Unknown status NCT00852787 Phase 4 Digoxin immune fab;Placebo
9 A comParison on Platelet Resistance With Ticagrelor or Standard-Dose Clopidogrel Study Among SeVerE Chronic Kidney Disease/ End-Stage-Renal-Disease Patients With Recent Acute Coronary Syndrome. Unknown status NCT02459288 Phase 4 Clopidogrel first;Ticagrelor first
10 A Pilot Study to Treat Patients With Chronic HCV Genotype 1 and ESRD Receiving Hemodialysis and Naïve to Prior HCV Therapy With Peginterferon Alfa-2b, the Maximally Tolerated Ribavirin Dose and Boceprevir Unknown status NCT01731301 Phase 4 Ribavirin;Peginterferon;Boceprevir
11 The Effect of Ferric Citrate on Inflammation and Lipid Levels in Patients on Hemodialysis Unknown status NCT02661295 Phase 4 Ferric Citrate
12 Calcineurin Inhibitor Minimisation in Renal Transplant Recipients With Stable Allograft Function: A Prospective Randomised Controlled Trial Unknown status NCT00541814 Phase 4 Cyclosporine
13 A Phase-IV Study Comparing Standard Release Tacrolimus (Prograf) vs Prolonged-release Tacrolimus (Advagraf) Monotherapy as Maintenance Immunosuppression After Induction With Alemtuzumab in Kidney Transplantation Unknown status NCT00807144 Phase 4 Tacrolimus (Kidney transplant maintenance immunosuppression);Kidney transplant maintenance immunosuppression
14 The Effect of Far Infrared (FIR) Therapy on Access Flow of Arteriovenous (AV) Fistula, Echocardiographic Parameters and Endothelial Function in Patients With End Stage Renal Disease Unknown status NCT01138254 Phase 4
15 Comparison of Onset of Action Between 2% Lidocaine Plus 0.5% Bupivacaine and 0.5% Bupivacaine in Brachial Plexus Anesthesia for Creation of Arteriovenous Fistula in ESRD Patient Unknown status NCT00993746 Phase 4 Bupivacaine plus lidocaine;Bupivacaine 30 ml
16 A Comparative Study of Dexmedetomidine and Propofol As Sole Sedative Agent for Patients With End-Stage Renal Disease Undergoing Arteriovenous Fistula Surgery Unknown status NCT02447796 Phase 4 Propofol;Dexmedetomidine
17 Hemocontrol's Effectiveness in a RAndomized Controlled Trial on the Reduction of Cardiovascular Long-term EventS Unknown status NCT01515878 Phase 4
18 Renoprotection by Combining Pentoxifylline and Angiotensin Blockade in Chronic Kidney Disease Unknown status NCT01377285 Phase 4 ARB;Pentoxifylline;Placebo (for Pentoxifylline)
19 The Determinants of the Effectiveness of the Use of Furosemide in Patients on Dialysis Unknown status NCT01815892 Phase 4 Withdrawal of furosemide;furosemide administration
20 Clinical Trial, Open, Parallel Groups , Value the Antiproteinuric Effects From Vitamin D Derivatives in Patient With Chronic Kidney Illness and the Lack of Vitamin D Unknown status NCT01442272 Phase 4 Hidroferol®;Paricalcitol: Zemplar®;Habitual medication
21 Renal Toxicity of Iodixanol and Iopromide in Patients With Renal Dysfunction—a Multicentre, Single Blind, Randomized Controlled, Prospective Trial Unknown status NCT01580046 Phase 4 iodixanol;iopromide
22 Protective Mechanisms of Aldosterone Antagonists and Their Effects on Cardiovascular Damage in Chronic Renal Failure: Clinical and Experimental Studies Unknown status NCT00277693 Phase 4 Spironolactone (drug)
23 Effect of Hydration With Sodium Bicarbonate for Long-Term Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing an Emergent Coronary Procedure Unknown status NCT00716001 Phase 4 N-acetylcysteine
24 Upstream Use of Aliskiren in Hypertensive Haemodialysis Patients: Effects on Cardiovascular Outcomes Unknown status NCT01635387 Phase 4 aliskiren
25 The Effects of AST-120 on Endothelial Dysfunction in Patients With Chronic Kidney Disease Unknown status NCT01157260 Phase 4 Kremezin
26 Pulse Wave Velocity, Pulse Wave Morphology and Blocking of the Reninangiotensin System in Patients With Chronic Kidney Disease: An Interventional and Methodological Study Unknown status NCT00235287 Phase 4 Candesartan and enalapril;candesartan and enalapril;candesartan and enalapril;candesartan and enalapril
27 Open Randomized Phase IV Study on Intravenous Iron in Anemic Patients With Chronic Kidney Disease Unknown status NCT00204256 Phase 4 Iron sucrose
28 The Metabolic and Anti-Inflammatory Effects of Combined Ezetimibe and Simvastin Therapy, as Compared to Simvastatin Alone, in Patients With Chronic Proteinuric Nephropathy Unknown status NCT00861731 Phase 4 simvastatin;EZE/simvastatin;EZE/simvastatin
29 Randomized, Open Label, Controlled Clinical Trial of Egg Albumin-Based Protein Supplement Versus Renal Specific Oral Supplement in Hemodialysis Patients Unknown status NCT01981083 Phase 4
30 NAC in Preventing CIN in CRF Patients Who Need Enhanced CT Scan in ED Unknown status NCT00501475 Phase 4 NAC Bicarbonate
31 Phase 4 Study of Medical Therapy Versus Medical Therapy Plus Renal Artery Stenting in Preventing the Progression of Renal Failure in Atherosclerotic Renovascular Disease Unknown status NCT01023373 Phase 4 Medical treatment
32 The Immunogenicity and Safety of the Seasonal Influenza Vaccine, Formulation 2013-2014, in Chronic Kidney Disease Patients Not on Dialysis Unknown status NCT02105519 Phase 4
33 Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus Unknown status NCT01073501 Phase 4 Pregabalin;Placebo
34 N-Acetylcysteine to Prevent Contrast-Induced Nephropathy in Acute Coronary Syndromes Unknown status NCT00939913 Phase 4 intravenous NAC;Placebo
35 Clinical Impact of Bacteriuria on Chronic Inflammation in Asymptomatic Hemodialysis Patients Unknown status NCT01570556 Phase 4
36 The Effects of Thiazolidinedione on the Diabetic Retinopathy and Nephropathy Unknown status NCT01175486 Phase 4 Actos (Pioglitazone);Acarbose
37 Lithium in Cardiac Surgery Related Acute Kidney Injury: A Pilot Study Unknown status NCT03056248 Phase 4 Placebo oral capsule;Lithium Carbonate
38 Interstitial Fibrosis in Protocol Biopsies of Renal Allografts: A Prospective, Randomised Trial of Sirolimus Versus Cyclosporine.(Fibrasic) Unknown status NCT00493194 Phase 4 sirolimus;cyclosporine;daclizumab
39 Effect of Short-term Synbiotic Treatment on Plasma P-cresol Levels in Hemodialysis Patients Unknown status NCT02311868 Phase 4
40 Phase 4 Study of Mechanisms of Low Protein Diet Supplemented With Ketoanalogs on Reducing Proteinuria and Maintaining Nutritional Status in Type 2 Diabetic Nephropathy Unknown status NCT01300273 Phase 4
41 Providing Intravenous Paricalcitol Treatment to the Sick and Poor Chronic Hemodialysis Patients With Severe Secondary Hyperparathyroidism Resistant to Existing Vitamin D Analogs Unknown status NCT03023748 Phase 4 Intravenous Paricalcitol
42 Evaluation of Cholecalciferol Supplementation in Chronic Kidney Disease Patients With Restless Leg Syndrome Unknown status NCT03063190 Phase 4 Vitamin D;Placebo Oral Tablet
43 Phase 4 Study of Alprostadil Prevent Contrast Induced Nephropathy in Patients Receiving a Cardiac Catheterization Unknown status NCT01722513 Phase 4 Alprostadil ﹠control
44 Effect of Ursodeoxycholic Acid on Peritoneal Function in Patients on Peritoneal Dialysis Unknown status NCT02338635 Phase 4 Ursodeoxycholic Acid
45 A Randomized Prospective Trial of N-acetyl Cystein in Patients With Peritoneal Dialysis Unknown status NCT01111422 Phase 4 N-acetylcysteine
46 Hypervolemia and Treatment Guided by Bioimpedance in End Stage Renal Disease Patients in Zonguldak (Prospective Study) Unknown status NCT01468363 Phase 4
47 Peripheral Artery Disease in Patients on Maintenance Hemodialysis: Risk Factors and the Effect of FIR Therapy Unknown status NCT01095549 Phase 4
48 Clinical Trial Technology Development for the Validation of Surrogate Prognostic Markers in Patients With Diabetic Nephropathy Unknown status NCT01673204 Phase 4 Calcitriol;Placebo
49 Low-molecular Heparin Infusion as Anticoagulation for Nocturnal Home Hemodialysis Unknown status NCT02957877 Phase 4 Nadroparin;Unfractionated heparin
50 Phase IV, Effect of Rennin-Angiotensin System Blockers on Glomerular Filtration Rate in Patients With Hypertension, Type 2 Diabetes With Normoalbuminuria--- A Randomized Controlled Trial Unknown status NCT01500590 Phase 4 Renin-angiotensin system blockers;non-renin angiotensin system blockers

Search NIH Clinical Center for End Stage Renal Failure

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Aluminum carbonate
basic aluminum carbonate gel
Bumetanide
calcium acetate
Calcium Carbonate
CALCIUM CARBONATE 1 g in 1 g ORAL POWDER
Calcium gluceptate
Cholecalciferol
Dihydrotachysterol
dihydroxyaluminum sodium carbonate
Ethacrynate Sodium
Ethacrynic Acid
Ferric pyrophosphate
Furosemide
magaldrate
Magnesium Hydroxide
MILK OF MAGNESIA
torsemide

Genetic Tests for End Stage Renal Failure

Anatomical Context for End Stage Renal Failure

MalaCards organs/tissues related to End Stage Renal Failure:

41
Kidney, Heart, Bone, Liver, Endothelial, Pancreas, Testes

Publications for End Stage Renal Failure

Articles related to End Stage Renal Failure:

(show top 50) (show all 35427)
# Title Authors PMID Year
1
Knockdown of ANGPTL-4 inhibits inflammatory response and extracellular matrix accumulation in glomerular mesangial cells cultured under high glucose condition. 38
31387395 2019
2
Prophylactic laparoscopic omentopexy: a new technique for peritoneal dialysis catheter placement. 38
30909767 2019
3
Hepcidin and diabetes are independently related with soluble transferrin receptor levels in chronic dialysis patients. 38
31296086 2019
4
The association of overhydration with megafistulas in hemodialysis patients. 38
31162990 2019
5
Bedside placement of peritoneal dialysis catheters - a single-center experience from Hungary. 38
31162993 2019
6
Serum alkaline phosphatase levels correlate with long-term mortality solely in peritoneal dialysis patients with residual renal function. 38
31409217 2019
7
FFNT25 ameliorates unilateral ureteral obstruction-induced renal fibrosis. 38
31140898 2019
8
High neutrophil/lymphocyte ratio is associated with poor renal outcomes in Japanese patients with chronic kidney disease. 38
30942116 2019
9
Critical role of mitochondrial dysfunction and impaired mitophagy in diabetic nephropathy. 38
31032918 2019
10
The effect of hemodialysis on ocular changes in patients with the end-stage renal disease. 38
31269848 2019
11
Association of Staphylococcus nasal colonization and HIV in end-stage renal failure patients undergoing peritoneal dialysis. 38
30991864 2019
12
Deletion of discoidin domain receptor 2 attenuates renal interstitial fibrosis in a murine unilateral ureteral obstruction model. 38
31169440 2019
13
Epidemiology investigation and analysis of patients with hemodialysis in Sichuan province of China. 38
31296088 2019
14
Baseline proteinuria level is associated with prognosis in idiopathic membranous nephropathy. 38
31057017 2019
15
Hirudin ameliorates immunoglobulin A nephropathy by inhibition of fibrosis and inflammatory response. 38
30880546 2019
16
Tracheobronchial calcification on bronchoscopy in a patient with end stage renal failure: an unusual cause of chronic cough. 38
31312454 2019
17
[Chronic metabolic and renal disorders related to lithium salts treatment]. 38
30827493 2019
18
A novel UMOD gene mutation associated with chronic kidney failure at a young age. 38
29424336 2019
19
Echocardiographic assessment of cardiac structure and function in chronic renal disease. 38
31286437 2019
20
Association between BMI changes and mortality risk in children with end-stage renal disease. 38
30963283 2019
21
Advanced type 1 hyperoxaluria presenting as livedo racemosa in a patient with end-stage renal disease. 38
31397396 2019
22
Changes in left ventricular filling parameters before and after dialysis in patients with end stage renal disease. 38
31093896 2019
23
Female preterm indigenous Australian infants have lower renal volumes than males: A predisposing factor for end-stage renal disease? 38
30350455 2019
24
Endothelial injury is closely related to osteopontin and TNF receptor-mediated inflammation in end-stage renal disease. 38
31153055 2019
25
Donor and post-transplant ureteroscopy for stone disease in patients with renal transplant: evidence from a systematic review. 38
30855381 2019
26
Factors associated with quality-of-life among Kuwaiti patients on maintenance hemodialysis. 38
31122052 2019
27
Emergency brachial artery ligation for ruptured infected pseudoaneurysm of haemodialysis access is a possible option. 38
30486731 2019
28
Vancomycin-associated Nephrotoxicity and Risk Factors in Critically Ill Children Without Preexisting Renal Injury. 38
31232892 2019
29
Association of CREBRF variants with obesity and diabetes in Pacific Islanders from Guam and Saipan. 38
31280340 2019
30
Markers of Collagen Formation and Degradation Reflect Renal Function and Predict Adverse Outcomes in Patients With Type 1 Diabetes. 38
31262950 2019
31
Discriminatory power of scoring systems for outcome prediction in patients with extracorporeal membrane oxygenation following cardiovascular surgery†. 38
30789227 2019
32
Perioperative Management of Spinal Tuberculosis in Patients with End-Stage Renal Disease: A Preliminary Report on A Patient Series. 38
31150864 2019
33
Four-jointed knock-out delays renal failure in an ADPKD model with kidney injury. 38
31038742 2019
34
Clinical and histological features and therapeutic strategies for IgA nephropathy. 38
30968243 2019
35
Urinary biomarkers of tubular injury to predict renal progression and end stage renal disease in type 2 diabetes mellitus with advanced nephropathy: A prospective cohort study. 38
31227289 2019
36
PC-1 NF suppresses high glucose-stimulated inflammation and extracellular matrix accumulation in glomerular mesangial cells via the Wnt/β-catenin signaling. 38
31410160 2019
37
Methylglyoxal as a prognostic factor in patients with chronic kidney disease. 38
30407693 2019
38
LC3 promotes the nuclear translocation of the vitamin D receptor and decreases fibrogenic gene expression in proximal renal tubules. 38
31226352 2019
39
Risk factors for relapse and long-term outcome of idiopathic retroperitoneal fibrosis. 38
31230189 2019
40
Pancreatic panniculitis in active systemic lupus erythematosus. 38
31081550 2019
41
Impaired mental health status in patients with chronic kidney disease is associated with estimated glomerular filtration rate decline. 38
30334305 2019
42
Low HDL cholesterol as a predictor of chronic kidney disease progression: a cross-classification approach and matched cohort analysis. 38
30874893 2019
43
Evaluation and Active Treatment versus Active Surveillance of Localized Prostate Cancer in Renal Transplant Patients in the Era of Low and Very Low Risk Prostate Cancer. 38
30835631 2019
44
The association between hepatitis B, hepatitis C and systemic sclerosis: a cross-sectional study. 38
31356380 2019
45
Soft Tissue Infection with Diaporthe phaseolorum in Heart Transplant Recipient with End-Stage Renal Failure. 38
31237834 2019
46
Is immunoglobulin A nephropathy different in different ethnic populations? 38
30977248 2019
47
Reduction in urinary oxalate excretion in mouse models of Primary Hyperoxaluria by RNA interference inhibition of liver lactate dehydrogenase activity. 38
31055082 2019
48
A review on protective role of genistein against oxidative stress in diabetes and related complications. 38
31125535 2019
49
Penile calciphyilaxis treated with daily Tadalafil: Case report. 38
31372344 2019
50
Exposure to environmental pollutants and a marker of early kidney injury in the general population: Results of a nationally representative cross-sectional study based on the Korean National Environmental Health Survey (KoNEHS) 2012-2014. 38
31103655 2019

Variations for End Stage Renal Failure

ClinVar genetic disease variations for End Stage Renal Failure:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 PKD1 NM_001009944.3(PKD1): c.2079dup (p.Pro694fs) duplication Pathogenic rs1057518923 16:2165397-2165397 16:2115396-2115396
2 GATA3 NM_001002295.2(GATA3): c.1051-1G> C single nucleotide variant Pathogenic rs112417755 10:8115701-8115701 10:8073738-8073738
3 COL4A4 NM_000092.4(COL4A4): c.4217-15T> C single nucleotide variant Conflicting interpretations of pathogenicity rs200926310 2:227877028-227877028 2:227012312-227012312
4 COL4A4 NM_000092.4(COL4A4): c.3055G> C (p.Glu1019Gln) single nucleotide variant Uncertain significance rs1057518854 2:227915788-227915788 2:227051072-227051072

Expression for End Stage Renal Failure

Search GEO for disease gene expression data for End Stage Renal Failure.

Pathways for End Stage Renal Failure

Pathways related to End Stage Renal Failure according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1 12.74 TGFB1 IL6 FN1 EPO COL4A5
2
Show member pathways
12.45 TNF TGFB1 IL6 GATA3
3
Show member pathways
12.22 TNF IL6 CRP ALB
4
Show member pathways
12.14 TNF TGFB1 IL6 ACE
5 11.92 WT1 TGFB1 IL6 ALB
6
Show member pathways
11.89 TNF TGFB1 IL6 GATA3
7 11.89 TNF TGFB1 IL6 GATA3 AGT
8 11.78 TNF TGFB1 IL6 GATA3 FN1
9 11.77 TNF TGFB1 IL6
10
Show member pathways
11.72 IL6 CRP AGT
11 11.65 TNF TGFB1 IL6 FN1 COL4A5
12 11.64 TNF TGFB1 IL6
13 11.62 TNF TGFB1 IL6
14 11.56 TNF TGFB1 IL6 FN1 COL4A5
15 11.55 TNF TGFB1 IL6
16 11.42 TNF TGFB1 IL6
17 11.41 TGFB1 FN1 COL4A5
18 11.39 TGFB1 IL6 EPO
19 11.38 TNF IL6 FN1
20 11.34 TNF PTH IL6
21 11.14 TNF IL6 GATA3
22 11.07 TNF TGFB1 IL6
23 10.97 WT1 TGFB1 NPHS2 NPHS1 MYH9 COL4A5
24 10.93 TNF TGFB1 IL6 FN1 COL4A5
25 10.9 TGFB1 PKD1 FN1
26 10.54 TNF IL6 FN1 CRP

GO Terms for End Stage Renal Failure

Cellular components related to End Stage Renal Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.85 UMOD PKD1 NPHS2 NPHS1 MYH9 FN1
2 extracellular region GO:0005576 9.77 UMOD TNF TGFB1 PTH IL6 FN1
3 endoplasmic reticulum lumen GO:0005788 9.65 IL6 FN1 CST3 COL4A5 ALB
4 blood microparticle GO:0072562 9.62 TGFB1 FN1 ALB AGT
5 platelet alpha granule lumen GO:0031093 9.54 TGFB1 FN1 ALB
6 slit diaphragm GO:0036057 9.4 NPHS2 NPHS1
7 extracellular space GO:0005615 9.4 TNF TGFB1 PTH IL6 FN1 EPO

Biological processes related to End Stage Renal Failure according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.97 TNF TGFB1 GATA3 ACE
2 positive regulation of transcription, DNA-templated GO:0045893 9.95 WT1 TNF TGFB1 IL6 GATA3 EPO
3 cellular protein metabolic process GO:0044267 9.93 IL6 FN1 CST3 ALB
4 leukocyte migration GO:0050900 9.92 TNF TGFB1 MYH9 FN1
5 cytokine-mediated signaling pathway GO:0019221 9.89 TNF TGFB1 IL6 GATA3 FN1
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.87 TNF TGFB1 IL6 AGT
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.85 TGFB1 IL6 AGT
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.83 TNF TGFB1 IL6
9 heart development GO:0007507 9.83 WT1 TGFB1 PKD1
10 humoral immune response GO:0006959 9.78 TNF IL6 GATA3
11 positive regulation of fibroblast proliferation GO:0048146 9.75 TGFB1 FN1 AGT
12 excretion GO:0007588 9.7 UMOD NPHS2 NPHS1
13 cell activation GO:0001775 9.66 TGFB1 GATA3
14 response to salt stress GO:0009651 9.65 TNF EPO
15 positive regulation of cytokine production GO:0001819 9.65 TNF GATA3 AGT
16 mesenchymal to epithelial transition GO:0060231 9.64 WT1 GATA3
17 glomerular basement membrane development GO:0032836 9.64 WT1 NPHS1
18 neutrophil mediated immunity GO:0002446 9.62 IL6 ACE
19 negative regulation of fat cell differentiation GO:0045599 9.62 TNF TGFB1 IL6 GATA3
20 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.6 AGT ACE
21 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.59 IL6 GATA3
22 positive regulation of neuroinflammatory response GO:0150078 9.58 TNF IL6
23 negative regulation of extracellular matrix disassembly GO:0010716 9.56 TGFB1 CST3
24 metanephric ascending thin limb development GO:0072218 9.55 UMOD PKD1
25 kidney development GO:0001822 9.55 WT1 PKD1 GATA3 AGT ACE
26 calcium-independent cell-matrix adhesion GO:0007161 9.54 PKD1 FN1
27 positive regulation of superoxide anion generation GO:0032930 9.54 TGFB1 CRP AGT
28 positive regulation of mononuclear cell migration GO:0071677 9.51 TNF TGFB1
29 positive regulation of gene expression GO:0010628 9.5 WT1 TNF TGFB1 IL6 GATA3 FN1
30 regulation of renal output by angiotensin GO:0002019 9.46 AGT ACE
31 mononuclear cell proliferation GO:0032943 9.43 TGFB1 ACE
32 negative regulation of lipid storage GO:0010888 9.43 TNF IL6 CRP
33 acute-phase response GO:0006953 8.92 IL6 FN1 EPO CRP
34 positive regulation of transcription by RNA polymerase II GO:0045944 10.16 WT1 TNF TGFB1 PTH PKD1 IL6
35 negative regulation of transcription by RNA polymerase II GO:0000122 10.13 WT1 TNF TGFB1 PTH GATA3 EPO
36 negative regulation of cell proliferation GO:0008285 10.03 WT1 UMOD TGFB1 IL6 GATA3

Molecular functions related to End Stage Renal Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 TNF TGFB1 IL6 EPO

Sources for End Stage Renal Failure

3 CDC
7 CNVD
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10 dbSNP
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17 EFO
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19 FMA
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69 SNOMED-CT via HPO
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73 UMLS via Orphanet
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