MCID: END028
MIFTS: 37

Endemic Goiter

Categories: Metabolic diseases

Aliases & Classifications for Endemic Goiter

MalaCards integrated aliases for Endemic Goiter:

Name: Endemic Goiter 12 55 15 17 72
Iodine-Deficiency-Related Endemic Goitre 12
Euthyroid Goiter 72
Goiter, Endemic 44
Simple Goitre 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13198
ICD9CM 35 240.0
MeSH 44 D006043
NCIt 50 C35023
SNOMED-CT 68 56805008
ICD10 33 E01.0 E01.2
UMLS 72 C0018022 C0302859

Summaries for Endemic Goiter

Disease Ontology : 12 A nutritional deficiency disease characterized by noncancerous enlargement of the thyroid gland and has material basis in iodine deficiency.

MalaCards based summary : Endemic Goiter, also known as iodine-deficiency-related endemic goitre, is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and goiter. An important gene associated with Endemic Goiter is TPO (Thyroid Peroxidase), and among its related pathways/superpathways are Allograft rejection and Aldosterone synthesis and secretion. The drugs Iodine and Micronutrients have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and bone, and related phenotype is limbs/digits/tail.

Related Diseases for Endemic Goiter

Diseases related to Endemic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 goiter, multinodular 1, with or without sertoli-leydig cell tumors 32.5 TPO TG
2 goiter 31.4 TSHR TPO TG SERPINA7
3 nodular goiter 30.5 TSHR TPO TG
4 familial thyroid dyshormonogenesis 30.2 TPO TG
5 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.2 TSHR TPO TG
6 multinodular goiter 30.2 TSHR TPO TG
7 hyperthyroidism 30.1 TSHR TPO TG SERPINA7
8 papillary carcinoma 30.1 TSHR TPO TG
9 differentiated thyroid carcinoma 30.0 TSHR TPO TG
10 thyroid cancer, nonmedullary, 2 30.0 TSHR TPO TG
11 postsurgical hypothyroidism 30.0 TSHR TG
12 graves disease 1 30.0 TSHR TPO TG SERPINA7
13 papillary thyroid microcarcinoma 29.8 TSHR TG
14 graves' disease 29.7 TSHR TPO TG SERPINA7
15 nontoxic goiter 29.6 TSHR TPO TG SERPINA7
16 follicular adenoma 29.6 TSHR TPO TG
17 hypothyroidism 29.1 TSHR TSHB TPO TG SERPINA7
18 subacute thyroiditis 29.1 TSHR TPO TG SERPINA7
19 hashimoto thyroiditis 29.0 TSHR TSHB TPO TG
20 thyroiditis 28.8 TSHR TSHB TPO TG SERPINA7
21 congenital hypothyroidism 28.5 TSHR TSHB TPO TG SERPINA7
22 thyroid gland disease 27.6 TSHR TSHB TPO TG SERPINA7 PTH
23 thyroid carcinoma 10.7
24 adenoma 10.4
25 hyperparathyroidism 10.3
26 subacute lymphocytic thyroiditis 10.3 TPO TG
27 mutism 10.3
28 hashimoto encephalopathy 10.2 TSHR TPO
29 plummer's disease 10.2 TPO TG
30 dyshormonogenic goiter 10.2 TG SERPINA7
31 autoimmune disease 10.2
32 hypercarotenemia and vitamin a deficiency, autosomal dominant 10.2
33 keratomalacia 10.2
34 thyroid gland follicular carcinoma 10.2
35 premature menopause 10.2 TPO TG
36 pernicious anemia 10.2 TPO TG
37 thyroid hormone resistance, generalized, autosomal dominant 10.1 TG SERPINA7
38 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.1 TPO TG
39 substernal goiter 10.1 TG PTH
40 benign struma ovarii 10.1 TSHR TG
41 struma ovarii 10.1 TSHR TG
42 hypoparathyroidism 10.1
43 primary hyperparathyroidism 10.1
44 rheumatic disease 10.1
45 enthesopathy 10.1
46 water-clear cell adenoma 10.1 TG PTH
47 clear cell adenoma 10.1 TG PTH
48 branchiootic syndrome 1 10.1
49 athyreosis 10.1 TSHR TG
50 schizophrenia 10.0

Graphical network of the top 20 diseases related to Endemic Goiter:



Diseases related to Endemic Goiter

Symptoms & Phenotypes for Endemic Goiter

MGI Mouse Phenotypes related to Endemic Goiter:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 8.92 PTH TG TPO TSHR

Drugs & Therapeutics for Endemic Goiter

Drugs for Endemic Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational 7553-56-2 807
2 Micronutrients
3 Anti-Infective Agents, Local
4 Nutrients
5 Trace Elements
6 Anti-Infective Agents
7 cadexomer iodine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Iodine Supplementation in Pregnant Women Living in Mild-to-moderately Iodine Deficient Areas in India and Thailand: Effects on Pregnancy Outcome and Infant Development Completed NCT00791466
2 Cases of Goiter in Children Attending Assiut University Children Hospital Not yet recruiting NCT03202160

Search NIH Clinical Center for Endemic Goiter

Cochrane evidence based reviews: goiter, endemic

Genetic Tests for Endemic Goiter

Anatomical Context for Endemic Goiter

MalaCards organs/tissues related to Endemic Goiter:

41
Thyroid, Testes, Bone, Pituitary, Liver, Tonsil, Cortex

Publications for Endemic Goiter

Articles related to Endemic Goiter:

(show top 50) (show all 1531)
# Title Authors PMID Year
1
Sensitivity of iodine deficiency indicators and iodine status in Turkey. 9 38
12713257 2003
2
Relationship between intrathyroid calcifications and thyroglobulin in endemic goiter. 9 38
10464709 1999
3
Thyroglobulin exon 10 gene point mutation in a patient with endemic goiter. 9 38
8936666 1996
4
Failure to detect thyroid growth-promoting activity in immunoglobulin G of patients with endemic goiter. 9 38
7909816 1994
5
The relationship between autoimmune thyroid disease and iodine intake: a review. 9 38
1345585 1992
6
TSH-receptor and adhesion molecules in autoimmune thyroid disease. 9 38
1468511 1992
7
Thyroid peroxidase in endemic goiter tissue. 9 38
2090669 1990
8
The representation of a goiter by Renaissance painter Moretto da Brescia. 38
30778906 2019
9
Goiter Prevalence and Interrelated Components from Coastal Karnataka. 38
30105567 2019
10
Dietary pattern and its association with iodine deficiency among school children in southwest Ethiopia; A cross-sectional study. 38
31408495 2019
11
Clinico-Pathological Profile of Anaplastic Thyroid Carcinoma in an Endemic Goiter Area. 38
30766820 2018
12
Endemic goiter and iodine deficiency status among Guinea-Bissau school-age children. 38
29284787 2018
13
Heritage of Stanislaw Ciechanowski (1869-1945)-Discoverer of pathogenesis of prostatic hyperplasia-passionis insignia signis fulgent mirificis . 38
29774590 2018
14
Mutational Profile of Papillary Thyroid Carcinoma in an Endemic Goiter Region of North India. 38
30148098 2018
15
Iodine nutrition status and prevalence of abnormal TSH levels in schoolchildren aged 6-7 years in the autonomous community of the Basque Country. 38
29650436 2018
16
Socio-demographic characters, distribution and transformation of iodine in soil, plant and wheat grains at District Diamer, Gilgit-Baltistan, Pakistan. 38
29027055 2018
17
Primary Epithelioid Angiosarcoma of the Thyroid in a Patient Occupationally Exposed to Radiations. 38
30327639 2018
18
Applicability of a shortened interpretation model for intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism in an endemic goiter region. 38
30294345 2018
19
Medical geology of endemic goiter in Kalutara, Sri Lanka; distribution and possible causes. 38
28551882 2017
20
Review of Iodine Nutrition in Iranian Population in the Past Quarter of Century. 38
29696034 2017
21
Concomitant thyroid lesions in patients with primary hyperparathyroidism. 38
26786663 2017
22
[Iodine prophylaxis, voices from the past after 65 years]. 38
29095024 2017
23
[From scientific research to health policy design: the experience of iodine deficiency elimination in Peru]. 38
29267780 2017
24
Boron - A potential goiterogen? 38
28673593 2017
25
The surgical approach to nodule Thyr 3-4 after the 2.2014 NCCN and 2015 ATA guidelines. 38
28506409 2017
26
Past, present, and future of iodine deficiency disorders in India: Need to look outside the blinkers. 38
29302513 2017
27
Historical aspects of iodine deficiency control. 38
28079353 2017
28
The way forward in Italy for iodine. 38
28079352 2017
29
[Congenital Hypothyroidism: 2 observed cases at the Gabriel Toure University Hospital of Bamako, Mali]. 38
30079685 2017
30
Role of Iodine in Metabolism. 38
28103777 2017
31
A community-based case-control study to investigate the role of iron deficiency in the persistence of goiter. 38
27366719 2016
32
Spectrum and prevalence of thyroid diseases seen at a tertiary health facility in Sagamu, South-West Nigeria. 38
27623725 2016
33
Consumption of iodized salt may not represent a reliable indicator of iodine adequacy: Evidence from a cross-sectional study on schoolchildren living in an urban area of central Italy. 38
26897110 2016
34
Prevalence of mental retardation in urban and rural populations of the goiter zone in Northwest India. 38
27350707 2016
35
Increase of papillary thyroid microcarcinoma and a plea for restrictive treatment: A retrospective study of 1,391 prospective documented patients. 38
26189948 2016
36
Incidental Papillary Thyroid Microcarcinoma in an Endemic Goiter Area. 38
26949559 2016
37
[Advances in thyroglobulin assays and their impact on the management of differentiated thyroid cancers]. 38
26711165 2016
38
The Mystery of Michelangelo Buonarroti's Goiter. 38
26886953 2016
39
Current status of iodine deficiency-related disorders prophylaxis in Slovakia - the life's work of Julian Podoba remained unfinished. 38
27560630 2016
40
Morbidity Associated with Concomitant Thyroid Surgery in Patients with Primary Hyperparathyroidism. 38
25480411 2015
41
Iodine nutritional status in Brazil: a meta-analysis of all studies performed in the country pinpoints to an insufficient evaluation and heterogeneity. 38
25926109 2015
42
[Hygienic characteristics of the population's morbidity rate associated with iodine deficiency in the Republic of Mordovia]. 38
26031044 2015
43
[From Geomorphological Research in the Canton of Aargau to European Military Pathologies. Entangling Anthropological Discourses of Crisis through the Army, 1860-1900]. 38
26902058 2015
44
[Thyroid surgery applicable in developing countries]. 38
25499094 2015
45
Electron microscopic analysis of an angiosarcoma of the thyroid from a non-Alpine endemic goiter region: A case report and brief review of the literature. 38
25289092 2014
46
Concept of double salt fortification; a tool to curtail micronutrient deficiencies and improve human health status. 38
24578322 2014
47
The Association between Cobalt Deficiency and Endemic Goiter in School-Aged Children. 38
25309789 2014
48
Surgical treatment of endemic goiter in a nonhospital setting without general anesthesia in Africa. 38
24728536 2014
49
[THE ROLE OF ADIPOCYTOKINES IN THE FORMATION OF INSULIN RESISTANCE IN PATIENTS WITH PRIMARY HYPOTHYROIDISM]. 38
26492788 2014
50
Protein-energy Malnutrition in Goitrous Schoolchildren of Isfahan, Iran. 38
24932384 2014

Variations for Endemic Goiter

Expression for Endemic Goiter

Search GEO for disease gene expression data for Endemic Goiter.

Pathways for Endemic Goiter

GO Terms for Endemic Goiter

Biological processes related to Endemic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.26 TSHR PTH
2 hormone-mediated signaling pathway GO:0009755 9.16 TSHR TSHB
3 cell-cell signaling GO:0007267 9.13 TSHR TSHB PTH
4 hormone biosynthetic process GO:0042446 8.62 TPO TG

Molecular functions related to Endemic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 TSHB TG PTH

Sources for Endemic Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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