MCID: END028
MIFTS: 37

Endemic Goiter

Categories: Metabolic diseases

Aliases & Classifications for Endemic Goiter

MalaCards integrated aliases for Endemic Goiter:

Name: Endemic Goiter 12 54 15 17 71
Iodine-Deficiency-Related Endemic Goitre 12
Euthyroid Goiter 71
Goiter, Endemic 43
Simple Goitre 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13198
ICD9CM 34 240.0
MeSH 43 D006043
NCIt 49 C35023
SNOMED-CT 67 56805008
ICD10 32 E01.2
UMLS 71 C0018022 C0302859

Summaries for Endemic Goiter

Disease Ontology : 12 A nutritional deficiency disease characterized by noncancerous enlargement of the thyroid gland and has material basis in iodine deficiency.

MalaCards based summary : Endemic Goiter, also known as iodine-deficiency-related endemic goitre, is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity. An important gene associated with Endemic Goiter is TPO (Thyroid Peroxidase), and among its related pathways/superpathways are Allograft rejection and Aldosterone synthesis and secretion. The drugs Methimazole and Iodine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and bone, and related phenotype is limbs/digits/tail.

Related Diseases for Endemic Goiter

Diseases related to Endemic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 goiter, multinodular 1, with or without sertoli-leydig cell tumors 32.7 TPO TG
2 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.7 TSHR TPO TG
3 adenoma 30.7 TSHR TG PTH
4 thyroid carcinoma 30.6 TSHR TPO TG CALCA
5 differentiated thyroid carcinoma 30.5 TSHR TPO TG
6 goiter 30.4 TSHR TPO TG SLC26A4 SERPINA7 IYD
7 transient congenital hypothyroidism 30.4 TSHR TPO
8 graves' disease 30.4 TSHR TPO TG SERPINA7
9 nodular goiter 30.3 TSHR TPO TG CALCA
10 thyroid cancer, nonmedullary, 2 30.1 TSHR TG CALCA
11 thyroid tumor 30.1 TPO TG
12 familial thyroid dyshormonogenesis 30.0 TPO TG IYD
13 fetal adenoma 30.0 TG CALCA
14 postsurgical hypothyroidism 29.9 TPO TG PTH
15 thyroid angiosarcoma 29.9 TG CALCA
16 papillary carcinoma 29.9 TSHR TPO TG CALCA
17 hypoparathyroidism 29.9 TPO PTH CALCA
18 subacute thyroiditis 29.8 TSHR TPO TG SERPINA7
19 papillary thyroid microcarcinoma 29.7 TSHR TG CALCA
20 hyperthyroidism 29.7 TSHR TPO TG SERPINA7 PTH CALCA
21 thyroid gland medullary carcinoma 29.6 TG CHST14 CALCA
22 graves disease 1 29.5 TSHR TPO TG SERPINA7 PTH CALCA
23 nontoxic goiter 29.1 TSHR TPO TG SERPINA7 PTH CALCA
24 multinodular goiter 29.0 TSHR TPO TG SLC26A4 PTH CALCA
25 thyroiditis 29.0 TSHR TSHB TPO TG SLC26A4 SERPINA7
26 hashimoto thyroiditis 29.0 TSHR TSHB TPO TG SLC26A4 CALCA
27 congenital hypothyroidism 29.0 TSHR TSHB TPO TG SLC26A4 SERPINA7
28 hypothyroidism 28.9 TSHR TSHB TPO TG SLC26A4 SERPINA7
29 follicular adenoma 28.8 TSHR TPO TG SLC26A4 CALCA
30 thyroid gland anaplastic carcinoma 28.4 TSHR TPO TG SLC26A4 CHST14 CALCA
31 thyroid gland cancer 27.9 TSHR TPO TG SLC26A4 PTH CHST14
32 thyroid gland disease 27.1 TSHR TSHB TPO TG SLC26A4 SERPINA7
33 mechanical strabismus 10.4 TPO TG
34 hashimoto encephalopathy 10.4 TSHR TPO
35 hyperparathyroidism 10.4
36 neonatal thyrotoxicosis 10.3 TSHR TG
37 diabetes mellitus, insulin-dependent, 20 10.3 TPO TG
38 euthyroid sick syndrome 10.3 TG SERPINA7
39 premature menopause 10.3 TPO TG
40 struma ovarii 10.3 TSHR TG
41 mutism 10.3
42 adrenal cortical hypofunction 10.3 TPO TG
43 orbital disease 10.3 TSHR TG
44 pernicious anemia 10.2 TPO TG
45 clear cell adenoma 10.2 TG PTH
46 tall cell variant papillary carcinoma 10.2 TG PTH
47 autoimmune disease 10.2
48 hypercarotenemia and vitamin a deficiency, autosomal dominant 10.2
49 primary hyperparathyroidism 10.2
50 keratomalacia 10.2

Graphical network of the top 20 diseases related to Endemic Goiter:



Diseases related to Endemic Goiter

Symptoms & Phenotypes for Endemic Goiter

MGI Mouse Phenotypes related to Endemic Goiter:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.02 CHST14 PTH TG TPO TSHR

Drugs & Therapeutics for Endemic Goiter

Drugs for Endemic Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methimazole Approved 60-56-0 1349907
2
Iodine Approved, Investigational 7553-56-2 807
3 Hormone Antagonists
4 Antithyroid Agents
5 Hormones
6 cadexomer iodine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cases of Goiter in Children Attending Assiut University Children Hospital Unknown status NCT03202160
2 Prevention of Iodinated Contrast Media Induced Hyperthyroidism in Patients With Euthyroid Goiter Completed NCT04304794 Prophylactic administration of antithyroid drugs before iodinated contrast media exposure
3 Iodine Supplementation in Pregnant Women Living in Mild-to-moderately Iodine Deficient Areas in India and Thailand: Effects on Pregnancy Outcome and Infant Development Completed NCT00791466

Search NIH Clinical Center for Endemic Goiter

Cochrane evidence based reviews: goiter, endemic

Genetic Tests for Endemic Goiter

Anatomical Context for Endemic Goiter

MalaCards organs/tissues related to Endemic Goiter:

40
Thyroid, Testes, Bone, Pituitary, Liver, Tonsil, Cortex

Publications for Endemic Goiter

Articles related to Endemic Goiter:

(show top 50) (show all 1544)
# Title Authors PMID Year
1
Sensitivity of iodine deficiency indicators and iodine status in Turkey. 61 54
12713257 2003
2
Relationship between intrathyroid calcifications and thyroglobulin in endemic goiter. 61 54
10464709 1999
3
Thyroglobulin exon 10 gene point mutation in a patient with endemic goiter. 61 54
8936666 1996
4
Failure to detect thyroid growth-promoting activity in immunoglobulin G of patients with endemic goiter. 61 54
7909816 1994
5
The relationship between autoimmune thyroid disease and iodine intake: a review. 61 54
1345585 1992
6
TSH-receptor and adhesion molecules in autoimmune thyroid disease. 61 54
1468511 1992
7
Thyroid peroxidase in endemic goiter tissue. 61 54
2090669 1990
8
High prevalence of TPO-Abs and subclinical hypothyroidism in iodine-sufficient pregnant women in Northern Algeria. 61
32417633 2020
9
Positive central lymph-nodes are underdiagnosed in patients with Bethesda V cytology in an endemic goiter region. 61
32420249 2020
10
Effects of bamboo shoots (Bambusa balcooa) on thyroid hormone synthesizing regulatory elements at cellular and molecular levels in thyrocytes. 61
31838178 2020
11
Selenium involvement in mitochondrial function in thyroid disorders. 61
31960358 2020
12
Thyroid cancer associated with Hashimoto thyroiditis: similarities and differences in an endemic area. 61
32372240 2020
13
Use of Thyroid Hormones in Hypothyroid and Euthyroid Patients; the 2019 Italian Survey. 61
32071899 2020
14
Review of Factors Contributing to Nodular Goiter and Thyroid Carcinoma. 61
31542786 2020
15
Analysis of Malignant Thyroid Neoplasms with a Striking Rise of Papillary Microcarcinoma in an Endemic Goiter Region. 61
31741946 2019
16
ARE THYROID NODULES AN OBSTACLE TO MINIMAL INVASIVE PARATHYROID SURGERY? A SINGLE-CENTER STUDY FROM AN ENDEMIC GOITER REGION. 61
32377254 2019
17
Endemic Goiter and Iodine Prophylaxis in Calabria, a Region of Southern Italy: Past and Present. 61
31614658 2019
18
The representation of a goiter by Renaissance painter Moretto da Brescia. 61
30778906 2019
19
Goiter Prevalence and Interrelated Components from Coastal Karnataka. 61
30105567 2019
20
Dietary pattern and its association with iodine deficiency among school children in southwest Ethiopia; A cross-sectional study. 61
31408495 2019
21
Thyroid Dysfunction and Cytological Patterns among Patients Requested for Thyroid Function Test in an Endemic Goiter Area of Gondar, North West Ethiopia. 61
31511773 2019
22
Clinico-Pathological Profile of Anaplastic Thyroid Carcinoma in an Endemic Goiter Area. 61
30766820 2018
23
Endemic goiter and iodine deficiency status among Guinea-Bissau school-age children. 61
29284787 2018
24
Heritage of Stanislaw Ciechanowski (1869-1945)-Discoverer of pathogenesis of prostatic hyperplasia-passionis insignia signis fulgent mirificis . 61
29774590 2018
25
Mutational Profile of Papillary Thyroid Carcinoma in an Endemic Goiter Region of North India. 61
30148098 2018
26
Iodine nutrition status and prevalence of abnormal TSH levels in schoolchildren aged 6-7 years in the autonomous community of the Basque Country. 61
29650436 2018
27
Socio-demographic characters, distribution and transformation of iodine in soil, plant and wheat grains at District Diamer, Gilgit-Baltistan, Pakistan. 61
29027055 2018
28
Primary Epithelioid Angiosarcoma of the Thyroid in a Patient Occupationally Exposed to Radiations. 61
30327639 2018
29
Applicability of a shortened interpretation model for intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism in an endemic goiter region. 61
30294345 2018
30
Medical geology of endemic goiter in Kalutara, Sri Lanka; distribution and possible causes. 61
28551882 2017
31
Review of Iodine Nutrition in Iranian Population in the Past Quarter of Century. 61
29696034 2017
32
Concomitant thyroid lesions in patients with primary hyperparathyroidism. 61
26786663 2017
33
[From scientific research to health policy design: the experience of iodine deficiency elimination in Peru]. 61
29267780 2017
34
[Iodine prophylaxis, voices from the past after 65 years]. 61
29095024 2017
35
Boron - A potential goiterogen? 61
28673593 2017
36
The surgical approach to nodule Thyr 3-4 after the 2.2014 NCCN and 2015 ATA guidelines. 61
28506409 2017
37
The way forward in Italy for iodine. 61
28079352 2017
38
Historical aspects of iodine deficiency control. 61
28079353 2017
39
Past, present, and future of iodine deficiency disorders in India: Need to look outside the blinkers. 61
29302513 2017
40
Role of Iodine in Metabolism. 61
28103777 2017
41
[Congenital Hypothyroidism: 2 observed cases at the Gabriel Toure University Hospital of Bamako, Mali]. 61
30079685 2017
42
Spectrum and prevalence of thyroid diseases seen at a tertiary health facility in Sagamu, South-West Nigeria. 61
27623725 2016
43
A community-based case-control study to investigate the role of iron deficiency in the persistence of goiter. 61
27366719 2016
44
Consumption of iodized salt may not represent a reliable indicator of iodine adequacy: Evidence from a cross-sectional study on schoolchildren living in an urban area of central Italy. 61
26897110 2016
45
Prevalence of mental retardation in urban and rural populations of the goiter zone in Northwest India. 61
27350707 2016
46
Increase of papillary thyroid microcarcinoma and a plea for restrictive treatment: A retrospective study of 1,391 prospective documented patients. 61
26189948 2016
47
Current status of iodine deficiency-related disorders prophylaxis in Slovakia - the life's work of Julian Podoba remained unfinished. 61
27560630 2016
48
Incidental Papillary Thyroid Microcarcinoma in an Endemic Goiter Area. 61
26949559 2016
49
[Advances in thyroglobulin assays and their impact on the management of differentiated thyroid cancers]. 61
26711165 2016
50
The Mystery of Michelangelo Buonarroti's Goiter. 61
26886953 2016

Variations for Endemic Goiter

Expression for Endemic Goiter

Search GEO for disease gene expression data for Endemic Goiter.

Pathways for Endemic Goiter

GO Terms for Endemic Goiter

Cellular components related to Endemic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 TSHB TPO TG SERPINA7 PTH CALCA

Biological processes related to Endemic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.54 TSHR PTH CALCA
2 cell-cell signaling GO:0007267 9.46 TSHR TSHB PTH CALCA
3 activation of adenylate cyclase activity GO:0007190 9.4 TSHR CALCA
4 hormone biosynthetic process GO:0042446 9.32 TPO TG
5 thyroid hormone metabolic process GO:0042403 9.26 TG IYD
6 iodide transport GO:0015705 8.96 TG SLC26A4
7 thyroid hormone generation GO:0006590 8.8 TPO TG IYD

Molecular functions related to Endemic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 iodide peroxidase activity GO:0004447 8.96 TPO IYD
2 hormone activity GO:0005179 8.92 TSHB TG PTH CALCA

Sources for Endemic Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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