MCID: END028
MIFTS: 39

Endemic Goiter

Categories: Metabolic diseases

Aliases & Classifications for Endemic Goiter

MalaCards integrated aliases for Endemic Goiter:

Name: Endemic Goiter 12 56 15 17 74
Iodine-Deficiency-Related Endemic Goitre 12
Euthyroid Goiter 74
Goiter, Endemic 45
Simple Goitre 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13198
ICD9CM 36 240.0
MeSH 45 D006043
NCIt 51 C35023
SNOMED-CT 69 56805008
ICD10 34 E01.0 E01.2

Summaries for Endemic Goiter

Disease Ontology : 12 A nutritional deficiency disease characterized by noncancerous enlargement of the thyroid gland and has material basis in iodine deficiency.

MalaCards based summary : Endemic Goiter, also known as iodine-deficiency-related endemic goitre, is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and nontoxic goiter. An important gene associated with Endemic Goiter is TPO (Thyroid Peroxidase), and among its related pathways/superpathways are Allograft rejection and Aldosterone synthesis and secretion. The drugs Iodine and Nutrients have been mentioned in the context of this disorder. Affiliated tissues include thyroid, t cells and testes, and related phenotype is limbs/digits/tail.

Related Diseases for Endemic Goiter

Diseases related to Endemic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 goiter, multinodular 1, with or without sertoli-leydig cell tumors 32.2 TG TPO
2 nontoxic goiter 31.6 SERPINA7 TG TPO TSHR
3 goiter 31.3 SERPINA7 TG TPO TSHR
4 graves disease 1 29.8 SERPINA7 TG TPO TSHR
5 papillary thyroid microcarcinoma 29.8 TG TSHR
6 thyroid cancer 29.8 TG TPO TSHB TSHR
7 multinodular goiter 29.7 TG TPO TSHR
8 differentiated thyroid carcinoma 29.7 TG TPO TSHR
9 thyroid cancer, nonmedullary, 2 29.7 TG TPO TSHR
10 hyperthyroidism 29.4 SERPINA7 TG TPO TSHR
11 hypothyroidism 29.3 SERPINA7 TG TPO TSHB TSHR
12 hashimoto thyroiditis 28.9 TG TPO TSHB TSHR
13 thyroiditis 28.9 SERPINA7 TG TPO TSHB TSHR
14 fetal iodine deficiency disorder 10.2
15 subacute lymphocytic thyroiditis 10.2 TG TPO
16 familial thyroid dyshormonogenesis 10.2 TG TPO
17 hashimoto encephalopathy 10.1 TPO TSHR
18 hyperparathyroidism 10.1
19 plummer's disease 10.1 TG TPO
20 dyshormonogenic goiter 10.1 SERPINA7 TG
21 premature menopause 10.1 TG TPO
22 pernicious anemia 10.1 TG TPO
23 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.1 TG TPO
24 substernal goiter 10.1 PTH TG
25 benign struma ovarii 10.1 TG TSHR
26 struma ovarii 10.1 TG TSHR
27 thyroid hormone resistance, generalized, autosomal dominant 10.1 SERPINA7 TG
28 water-clear cell adenoma 10.1 PTH TG
29 clear cell adenoma 10.1 PTH TG
30 athyreosis 10.1 TG TSHR
31 postsurgical hypothyroidism 10.0 TG TSHR
32 pendred syndrome 10.0 TG TPO
33 turner syndrome 10.0 TG TPO
34 exophthalmos 10.0 TG TSHR
35 cell type benign neoplasm 9.9 PTH TG
36 hyperthyroxinemia 9.9 SERPINA7 TPO TSHR
37 celiac disease 1 9.9 TG TPO
38 myxedema 9.9 TG TPO TSHR
39 nodular goiter 9.9 TG TPO TSHR
40 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9 TG TPO TSHR
41 follicular adenoma 9.9 TG TPO TSHR
42 autoimmune disease 9.9
43 hypercarotenemia and vitamin a deficiency, autosomal dominant 9.9
44 thyroid carcinoma, familial medullary 9.9
45 thyroid cancer, nonmedullary, 1 9.9
46 insulin-like growth factor i 9.9
47 thyrotropin-releasing hormone deficiency 9.9
48 angiosarcoma 9.9
49 tracheomalacia 9.9
50 thyroid gland anaplastic carcinoma 9.9

Graphical network of the top 20 diseases related to Endemic Goiter:



Diseases related to Endemic Goiter

Symptoms & Phenotypes for Endemic Goiter

MGI Mouse Phenotypes related to Endemic Goiter:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 8.92 PTH TG TPO TSHR

Drugs & Therapeutics for Endemic Goiter

Drugs for Endemic Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Not Applicable 7553-56-2 807
2 Nutrients Not Applicable
3 Anti-Infective Agents Not Applicable
4 Micronutrients Not Applicable
5 Anti-Infective Agents, Local Not Applicable
6 Trace Elements Not Applicable
7 cadexomer iodine Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Maternal Iodine Supplementation and Effects on Thyroid Function and Child Development Completed NCT00791466 Not Applicable

Search NIH Clinical Center for Endemic Goiter

Cochrane evidence based reviews: goiter, endemic

Genetic Tests for Endemic Goiter

Anatomical Context for Endemic Goiter

MalaCards organs/tissues related to Endemic Goiter:

42
Thyroid, T Cells, Testes, Cortex, Bone, Pituitary, Tonsil

Publications for Endemic Goiter

Articles related to Endemic Goiter:

(show top 50) (show all 337)
# Title Authors Year
1
Endemic goiter and iodine deficiency status among Guinea-Bissau school-age children. ( 29284787 )
2018
2
Mutational Profile of Papillary Thyroid Carcinoma in an Endemic Goiter Region of North India. ( 30148098 )
2018
3
Applicability of a shortened interpretation model for intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism in an endemic goiter region. ( 30294345 )
2018
4
Clinico-Pathological Profile of Anaplastic Thyroid Carcinoma in an Endemic Goiter Area. ( 30766820 )
2018
5
Medical geology of endemic goiter in Kalutara, Sri Lanka; distribution and possible causes. ( 28551882 )
2017
6
Incidental Papillary Thyroid Microcarcinoma in an Endemic Goiter Area. ( 26949559 )
2016
7
Electron microscopic analysis of an angiosarcoma of the thyroid from a non-Alpine endemic goiter region: A case report and brief review of the literature. ( 25289092 )
2014
8
Surgical treatment of endemic goiter in a nonhospital setting without general anesthesia in Africa. ( 24728536 )
2014
9
The Association between Cobalt Deficiency and Endemic Goiter in School-Aged Children. ( 25309789 )
2014
10
Role of bamboo-shoot in the pathogenesis of endemic goiter in manipur, north East India. ( 23186959 )
2013
11
State of the art: surgery for endemic goiter. ( 22083604 )
2012
12
Clinicopathological profile, airway management, and outcome in huge multinodular goiters: an institutional experience from an endemic goiter region. ( 22302284 )
2012
13
Single lobe disease in cases of advanced endemic goiter: a new phenotype. ( 24783020 )
2012
14
Selenium deficiency a factor in endemic goiter persistence in sub-Saharan Africa. ( 21523503 )
2011
15
Thyroid autoimmunity role in the evolution of endemic goiter in rural area, Fars, Iran. ( 21529102 )
2011
16
State of the art: surgery for endemic goiter--a plea for individualizing the extent of resection instead of heading for routine total thyroidectomy. ( 21630080 )
2011
17
Endemic goiter--individual risk factors necessitate individual treatment. ( 22006052 )
2011
18
INCAP studies of endemic goiter and its prevention. ( 20461908 )
2010
19
Evidence of endemic goiter and iodine deficiency in a mountainous area of Haiti. ( 19454392 )
2009
20
Follicular thyroid carcinoma in an iodine-replete endemic goiter region: a prospectively collected, retrospectively analyzed clinical trial. ( 19474675 )
2009
21
The role of thyroid autoantibodies in the etiology of endemic goiter in schoolchildren of Isfahan, Iran. ( 19494708 )
2009
22
Etiological factors for the persistence of endemic goiter in selected areas of Siddharthnagar district in Eastern Uttar Pradesh, India. ( 19554805 )
2009
23
Malignancy rates in operated patients with hyperthyroidism in an area of endemic goiter. ( 20302029 )
2009
24
Does fine-needle aspiration cytology optimize the surgical management of thyroid disorders in endemic goiter region? ( 18202924 )
2008
25
Iodine deficiency and endemic goiter: a national tragedy. ( 18599928 )
2008
26
Endemic goiter in Semirom; there is no difference in vitamin A status between goitrous and nongoitrous children. ( 19155579 )
2008
27
The role of iodine in the evolution of thyroid disease in Greece: from endemic goiter to thyroid autoimmunity. ( 17324915 )
2007
28
High incidence of tracheomalacia in longstanding goiters: experience from an endemic goiter region. ( 17354028 )
2007
29
Endemic goiter due to thyroglobulin gene abnormality and social ostracism. ( 17446654 )
2007
30
Evaluation of endemic goiter prevalence in Bulgarian schoolchildren: results from national strategies for prevention and control of iodine-deficiency disorders. ( 17709907 )
2007
31
Clinical importance of solitary thyroid nodule of the thyroid in endemic goiter region. ( 16790952 )
2006
32
History of endemic goiter in Croatia: from severe iodine deficiency to iodine sufficiency. ( 16117293 )
2005
33
Clinical importance of solitary solid nodule of the thyroid in endemic goiter region. ( 16199924 )
2005
34
Prognostic factors of papillary and follicular thyroid cancer: differences in an iodine-replete endemic goiter region. ( 15027890 )
2004
35
Accuracy of preoperative pinhole subtraction single photon emission computed tomography for patients with primary and recurrent hyperparathyroidism in an endemic goiter area. ( 15170543 )
2004
36
Application of staging systems for differentiated thyroid carcinoma in an endemic goiter region with iodine substitution. ( 12560781 )
2003
37
Fluorine-18-fluorodeoxyglucose positron emission tomography in the preoperative assessment of thyroid nodules in an endemic goiter area. ( 12660642 )
2003
38
Impact of localization studies on feasibility of minimally invasive parathyroidectomy in an endemic goiter region. ( 12691928 )
2003
39
Influence of iodine deficiency and iodine prophylaxis on thyroid cancer histotypes and incidence in endemic goiter area. ( 12762644 )
2003
40
Iodine deficiency in Calabria: characterization of endemic goiter and analysis of different indicators of iodine status region-wide. ( 11936460 )
2002
41
Iodine and selenium deficiency in school-children in an endemic goiter area in Turkey. ( 12199330 )
2002
42
Iodized oil as a complement to iodized salt in schoolchildren in endemic goiter in Romania. ( 12207166 )
2002
43
Limited sensitivity of parathyroid imaging with (99m)Tc-sestamibi/(123)I subtraction in an endemic goiter area. ( 12215555 )
2002
44
Endemic goiter in pregnant women: utility of the simplified classification of thyroid size by palpation and urinary iodine as screening tests. ( 12504972 )
2002
45
Insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels of children living in an iodine- and selenium-deficient endemic goiter area. ( 12666822 )
2002
46
Endemic goiter--an update. ( 17018443 )
2002
47
Changes in serum thyroid hormone levels in newborn calves as a diagnostic index of endemic goiter. ( 11258455 )
2001
48
Thyroid hormone profile in children with goiter in an endemic goiter area. ( 11305795 )
2001
49
Endemic goiter, thiocyanate overload, and selenium status in school-age children. ( 11330518 )
2001
50
Dietary supplies of iodine and thiocyanate in the etiology of endemic goiter in Tripura. ( 11407152 )
2001

Variations for Endemic Goiter

Expression for Endemic Goiter

Search GEO for disease gene expression data for Endemic Goiter.

Pathways for Endemic Goiter

GO Terms for Endemic Goiter

Biological processes related to Endemic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.43 PTH TG TSHB
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.32 PTH TSHR
3 hormone-mediated signaling pathway GO:0009755 9.16 TSHB TSHR
4 cell-cell signaling GO:0007267 9.13 PTH TSHB TSHR
5 hormone biosynthetic process GO:0042446 8.62 TG TPO

Molecular functions related to Endemic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 PTH TG TSHB

Sources for Endemic Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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