MCID: END028
MIFTS: 37

Endemic Goiter

Categories: Metabolic diseases

Aliases & Classifications for Endemic Goiter

MalaCards integrated aliases for Endemic Goiter:

Name: Endemic Goiter 12 54 15 17 71
Iodine-Deficiency-Related Endemic Goitre 12
Euthyroid Goiter 71
Goiter, Endemic 43
Simple Goitre 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13198
ICD9CM 34 240.0
MeSH 43 D006043
NCIt 49 C35023
SNOMED-CT 67 56805008
ICD10 32 E01.0 E01.2
UMLS 71 C0018022 C0302859

Summaries for Endemic Goiter

Disease Ontology : 12 A nutritional deficiency disease characterized by noncancerous enlargement of the thyroid gland and has material basis in iodine deficiency.

MalaCards based summary : Endemic Goiter, also known as iodine-deficiency-related endemic goitre, is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity. An important gene associated with Endemic Goiter is TPO (Thyroid Peroxidase), and among its related pathways/superpathways are Allograft rejection and Aldosterone synthesis and secretion. The drugs Iodine and Micronutrients have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and bone, and related phenotype is limbs/digits/tail.

Related Diseases for Endemic Goiter

Diseases related to Endemic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 goiter, multinodular 1, with or without sertoli-leydig cell tumors 32.7 TPO TG
2 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.7 TSHR TPO TG
3 thyroid carcinoma 30.6 TSHR TPO TG CALCA
4 goiter 30.5 TSHR TPO TG SERPINA7 IYD CALCA
5 differentiated thyroid carcinoma 30.5 TSHR TPO TG
6 transient congenital hypothyroidism 30.4 TSHR TPO
7 nodular goiter 30.4 TSHR TPO TG CALCA
8 thyroid gland anaplastic carcinoma 30.3 TPO TG
9 graves' disease 30.3 TSHR TPO TG SERPINA7
10 thyroid cancer, nonmedullary, 2 30.2 TSHR TG CALCA
11 thyroid tumor 30.1 TPO TG
12 fetal adenoma 30.1 TG CALCA
13 thyroid angiosarcoma 30.1 TG CALCA
14 papillary carcinoma 30.0 TSHR TPO TG CALCA
15 thyroid gland medullary carcinoma 30.0 TG CALCA
16 thyroid gland follicular carcinoma 29.8 TSHR TG CHST14 CALCA
17 papillary thyroid microcarcinoma 29.8 TSHR TG CALCA
18 subacute thyroiditis 29.7 TSHR TPO TG SERPINA7
19 postsurgical hypothyroidism 29.7 TSHR TG PTH
20 hashimoto thyroiditis 29.6 TSHR TSHB TPO TG CALCA
21 thyroiditis 29.6 TSHR TSHB TPO TG SERPINA7 CALCA
22 hyperthyroidism 29.5 TSHR TPO TG SERPINA7 PTH CALCA
23 familial thyroid dyshormonogenesis 29.5 TPO TG IYD
24 follicular adenoma 29.5 TSHR TPO TG CALCA
25 multinodular goiter 29.4 TSHR TPO TG PTH CALCA
26 graves disease 1 29.3 TSHR TPO TG SERPINA7 PTH CALCA
27 nontoxic goiter 29.0 TSHR TPO TG SERPINA7 PTH CALCA
28 hypothyroidism 28.9 TSHR TSHB TPO TG SERPINA7 IYD
29 congenital hypothyroidism 28.9 TSHR TSHB TPO TG SERPINA7 IYD
30 thyroid gland cancer 28.3 TSHR TPO TG PTH CHST14 CALCA
31 thyroid gland disease 27.8 TSHR TSHB TPO TG SERPINA7 PTH
32 adenoma 10.4
33 mechanical strabismus 10.4 TPO TG
34 hashimoto encephalopathy 10.4 TSHR TPO
35 hyperparathyroidism 10.3
36 athyreosis 10.3 TSHR TG
37 neonatal thyrotoxicosis 10.3 TSHR TG
38 diabetes mellitus, insulin-dependent, 20 10.3 TPO TG
39 euthyroid sick syndrome 10.3 TG SERPINA7
40 premature menopause 10.3 TPO TG
41 adrenal cortical hypofunction 10.3 TPO TG
42 benign struma ovarii 10.3 TSHR TG
43 struma ovarii 10.3 TSHR TG
44 mutism 10.3
45 orbital disease 10.3 TSHR TG
46 pernicious anemia 10.3 TPO TG
47 thyroid gland mucoepidermoid carcinoma 10.2 TG CALCA
48 spindle epithelial tumor with thymus-like differentiation tumor 10.2 TG CALCA
49 autoimmune disease 10.2
50 hypercarotenemia and vitamin a deficiency, autosomal dominant 10.2

Graphical network of the top 20 diseases related to Endemic Goiter:



Diseases related to Endemic Goiter

Symptoms & Phenotypes for Endemic Goiter

MGI Mouse Phenotypes related to Endemic Goiter:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.02 CHST14 PTH TG TPO TSHR

Drugs & Therapeutics for Endemic Goiter

Drugs for Endemic Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational 7553-56-2 807
2 Micronutrients
3 Anti-Infective Agents
4 Nutrients
5 Trace Elements
6 cadexomer iodine
7 Anti-Infective Agents, Local

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cases of Goiter in Children Attending Assiut University Children Hospital Unknown status NCT03202160
2 Iodine Supplementation in Pregnant Women Living in Mild-to-moderately Iodine Deficient Areas in India and Thailand: Effects on Pregnancy Outcome and Infant Development Completed NCT00791466

Search NIH Clinical Center for Endemic Goiter

Cochrane evidence based reviews: goiter, endemic

Genetic Tests for Endemic Goiter

Anatomical Context for Endemic Goiter

MalaCards organs/tissues related to Endemic Goiter:

40
Thyroid, Testes, Bone, Liver, Tonsil, Pituitary, Thymus

Publications for Endemic Goiter

Articles related to Endemic Goiter:

(show top 50) (show all 1539)
# Title Authors PMID Year
1
Sensitivity of iodine deficiency indicators and iodine status in Turkey. 54 61
12713257 2003
2
Relationship between intrathyroid calcifications and thyroglobulin in endemic goiter. 54 61
10464709 1999
3
Thyroglobulin exon 10 gene point mutation in a patient with endemic goiter. 54 61
8936666 1996
4
Failure to detect thyroid growth-promoting activity in immunoglobulin G of patients with endemic goiter. 54 61
7909816 1994
5
The relationship between autoimmune thyroid disease and iodine intake: a review. 54 61
1345585 1992
6
TSH-receptor and adhesion molecules in autoimmune thyroid disease. 54 61
1468511 1992
7
Thyroid peroxidase in endemic goiter tissue. 54 61
2090669 1990
8
Effects of bamboo shoots (Bambusa balcooa) on thyroid hormone synthesizing regulatory elements at cellular and molecular levels in thyrocytes. 61
31838178 2020
9
Review of Factors Contributing to Nodular Goiter and Thyroid Carcinoma. 61
31542786 2020
10
Selenium involvement in mitochondrial function in thyroid disorders. 61
31960358 2020
11
Analysis of Malignant Thyroid Neoplasms with a Striking Rise of Papillary Microcarcinoma in an Endemic Goiter Region. 61
31741946 2019
12
Endemic Goiter and Iodine Prophylaxis in Calabria, a Region of Southern Italy: Past and Present. 61
31614658 2019
13
The representation of a goiter by Renaissance painter Moretto da Brescia. 61
30778906 2019
14
Goiter Prevalence and Interrelated Components from Coastal Karnataka. 61
30105567 2019
15
Thyroid Dysfunction and Cytological Patterns among Patients Requested for Thyroid Function Test in an Endemic Goiter Area of Gondar, North West Ethiopia. 61
31511773 2019
16
Dietary pattern and its association with iodine deficiency among school children in southwest Ethiopia; A cross-sectional study. 61
31408495 2019
17
Clinico-Pathological Profile of Anaplastic Thyroid Carcinoma in an Endemic Goiter Area. 61
30766820 2018
18
Endemic goiter and iodine deficiency status among Guinea-Bissau school-age children. 61
29284787 2018
19
Heritage of Stanislaw Ciechanowski (1869-1945)-Discoverer of pathogenesis of prostatic hyperplasia-passionis insignia signis fulgent mirificis . 61
29774590 2018
20
Mutational Profile of Papillary Thyroid Carcinoma in an Endemic Goiter Region of North India. 61
30148098 2018
21
Iodine nutrition status and prevalence of abnormal TSH levels in schoolchildren aged 6-7 years in the autonomous community of the Basque Country. 61
29650436 2018
22
Socio-demographic characters, distribution and transformation of iodine in soil, plant and wheat grains at District Diamer, Gilgit-Baltistan, Pakistan. 61
29027055 2018
23
Primary Epithelioid Angiosarcoma of the Thyroid in a Patient Occupationally Exposed to Radiations. 61
30327639 2018
24
Applicability of a shortened interpretation model for intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism in an endemic goiter region. 61
30294345 2018
25
Medical geology of endemic goiter in Kalutara, Sri Lanka; distribution and possible causes. 61
28551882 2017
26
Review of Iodine Nutrition in Iranian Population in the Past Quarter of Century. 61
29696034 2017
27
Concomitant thyroid lesions in patients with primary hyperparathyroidism. 61
26786663 2017
28
[From scientific research to health policy design: the experience of iodine deficiency elimination in Peru]. 61
29267780 2017
29
[Iodine prophylaxis, voices from the past after 65 years]. 61
29095024 2017
30
Boron - A potential goiterogen? 61
28673593 2017
31
The surgical approach to nodule Thyr 3-4 after the 2.2014 NCCN and 2015 ATA guidelines. 61
28506409 2017
32
Past, present, and future of iodine deficiency disorders in India: Need to look outside the blinkers. 61
29302513 2017
33
Historical aspects of iodine deficiency control. 61
28079353 2017
34
The way forward in Italy for iodine. 61
28079352 2017
35
[Congenital Hypothyroidism: 2 observed cases at the Gabriel Toure University Hospital of Bamako, Mali]. 61
30079685 2017
36
Role of Iodine in Metabolism. 61
28103777 2017
37
A community-based case-control study to investigate the role of iron deficiency in the persistence of goiter. 61
27366719 2016
38
Spectrum and prevalence of thyroid diseases seen at a tertiary health facility in Sagamu, South-West Nigeria. 61
27623725 2016
39
Consumption of iodized salt may not represent a reliable indicator of iodine adequacy: Evidence from a cross-sectional study on schoolchildren living in an urban area of central Italy. 61
26897110 2016
40
Prevalence of mental retardation in urban and rural populations of the goiter zone in Northwest India. 61
27350707 2016
41
Increase of papillary thyroid microcarcinoma and a plea for restrictive treatment: A retrospective study of 1,391 prospective documented patients. 61
26189948 2016
42
[Advances in thyroglobulin assays and their impact on the management of differentiated thyroid cancers]. 61
26711165 2016
43
Incidental Papillary Thyroid Microcarcinoma in an Endemic Goiter Area. 61
26949559 2016
44
The Mystery of Michelangelo Buonarroti's Goiter. 61
26886953 2016
45
Current status of iodine deficiency-related disorders prophylaxis in Slovakia - the life's work of Julian Podoba remained unfinished. 61
27560630 2016
46
Morbidity Associated with Concomitant Thyroid Surgery in Patients with Primary Hyperparathyroidism. 61
25480411 2015
47
Iodine nutritional status in Brazil: a meta-analysis of all studies performed in the country pinpoints to an insufficient evaluation and heterogeneity. 61
25926109 2015
48
[Hygienic characteristics of the population's morbidity rate associated with iodine deficiency in the Republic of Mordovia]. 61
26031044 2015
49
[From Geomorphological Research in the Canton of Aargau to European Military Pathologies. Entangling Anthropological Discourses of Crisis through the Army, 1860-1900]. 61
26902058 2015
50
[Thyroid surgery applicable in developing countries]. 61
25499094 2015

Variations for Endemic Goiter

Expression for Endemic Goiter

Search GEO for disease gene expression data for Endemic Goiter.

Pathways for Endemic Goiter

GO Terms for Endemic Goiter

Biological processes related to Endemic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone-mediated signaling pathway GO:0009755 9.4 TSHR TSHB
2 activation of adenylate cyclase activity GO:0007190 9.37 TSHR CALCA
3 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.33 TSHR PTH CALCA
4 thyroid hormone generation GO:0006590 9.32 TPO IYD
5 hormone biosynthetic process GO:0042446 9.26 TPO TG
6 thyroid hormone metabolic process GO:0042403 8.96 TG IYD
7 cell-cell signaling GO:0007267 8.92 TSHR TSHB PTH CALCA

Molecular functions related to Endemic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 iodide peroxidase activity GO:0004447 8.96 TPO IYD
2 hormone activity GO:0005179 8.92 TSHB TG PTH CALCA

Sources for Endemic Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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