MCID: END028
MIFTS: 39

Endemic Goiter

Categories: Endocrine diseases, Metabolic diseases

Aliases & Classifications for Endemic Goiter

MalaCards integrated aliases for Endemic Goiter:

Name: Endemic Goiter 12 55 15 73
Iodine-Deficiency-Related Endemic Goitre 12
Euthyroid Goiter 73
Goiter, Endemic 44
Simple Goitre 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13198
ICD10 33 E01.0 E01.2
ICD9CM 35 240.0
MeSH 44 D006043
NCIt 50 C35023

Summaries for Endemic Goiter

MalaCards based summary : Endemic Goiter, also known as iodine-deficiency-related endemic goitre, is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and nontoxic goiter. An important gene associated with Endemic Goiter is TPO (Thyroid Peroxidase), and among its related pathways/superpathways are Allograft rejection and Aldosterone synthesis and secretion. The drugs Iodine and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and cortex.

Related Diseases for Endemic Goiter

Diseases related to Endemic Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 goiter, multinodular 1, with or without sertoli-leydig cell tumors 32.3 TG TPO
2 nontoxic goiter 29.9 CALCA SERPINA7 TG TPO TSHR
3 acute thyroiditis 29.9 CALCA TG
4 goiter 29.7 CALCA SERPINA7 TG TPO TSHR
5 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.3 TG TPO TSHR
6 differentiated thyroid carcinoma 29.3 TG TPO TSHR
7 papillary thyroid microcarcinoma 29.1 CALCA TG TSHR
8 thyroid carcinoma, familial medullary 28.7 CALCA TG
9 multinodular goiter 28.7 CALCA TG TPO TSHR
10 hyperthyroidism 28.7 SERPINA7 TG TPO TSHR
11 thyroid cancer, nonmedullary, 2 28.5 CALCA TG TPO TSHR
12 thyroiditis 27.7 CALCA SERPINA7 TG TPO TSHB TSHR
13 thyroid cancer 27.6 CALCA TG TPO TSHB TSHR
14 hypothyroidism 26.9 CALCA SERPINA7 TG TPO TSHB TSHR
15 familial thyroid dyshormonogenesis 10.4 TG TPO
16 subacute lymphocytic thyroiditis 10.4 TG TPO
17 plummer's disease 10.3 TG TPO
18 dyshormonogenic goiter 10.3 SERPINA7 TG
19 premature menopause 10.3 TG TPO
20 pernicious anemia 10.3 TG TPO
21 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.3 TG TPO
22 thyroid hormone resistance, generalized, autosomal dominant 10.3 SERPINA7 TG
23 mucoepidermoid thyroid carcinoma 10.2 CALCA TG
24 suppurative thyroiditis 10.2 CALCA TG
25 thyroid sarcoma 10.2 CALCA TG
26 benign struma ovarii 10.2 TG TSHR
27 athyreosis 10.2 TG TSHR
28 anaplastic thyroid cancer 10.2 TG TPO
29 atypical follicular adenoma 10.2 CALCA TG
30 struma ovarii 10.2 TG TSHR
31 pendred syndrome 10.2 TG TPO
32 hypoadrenalism 10.1 CALCA TG
33 aging 10.1
34 turner syndrome 10.1 TG TPO
35 amyloid tumor 10.1 CALCA TG
36 ovarian cystic teratoma 10.1 CALCA TG
37 fetal iodine deficiency disorder 10.0
38 exophthalmos 10.0 TG TSHR
39 cowden disease 9.9 CALCA TG
40 hyperparathyroidism 9.9
41 cerebritis 9.9
42 hyperthyroxinemia 9.9 SERPINA7 TPO TSHR
43 mucoepidermoid carcinoma 9.9 CALCA TG
44 neonatal hypothyroidism 9.9 TG TPO TSHR
45 myxedema 9.8 TG TPO TSHR
46 hypersensitivity reaction disease 9.8 TG TPO TSHR
47 hypothyroidism, congenital, nongoitrous, 2 9.8 SERPINA7 TG TSHR
48 endocrine gland cancer 9.8 CALCA TG
49 autoimmune disease 9.7
50 hypercarotenemia and vitamin a deficiency, autosomal dominant 9.7

Graphical network of the top 20 diseases related to Endemic Goiter:



Diseases related to Endemic Goiter

Symptoms & Phenotypes for Endemic Goiter

Drugs & Therapeutics for Endemic Goiter

Drugs for Endemic Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Not Applicable 7553-56-2 807
2 Anti-Infective Agents Not Applicable
3 Anti-Infective Agents, Local Not Applicable
4 cadexomer iodine Not Applicable
5 Micronutrients Not Applicable
6 Trace Elements Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Maternal Iodine Supplementation and Effects on Thyroid Function and Child Development Completed NCT00791466 Not Applicable

Search NIH Clinical Center for Endemic Goiter

Cochrane evidence based reviews: goiter, endemic

Genetic Tests for Endemic Goiter

Anatomical Context for Endemic Goiter

MalaCards organs/tissues related to Endemic Goiter:

41
Thyroid, Testes, Cortex, Pituitary, Tonsil, Bone

Publications for Endemic Goiter

Articles related to Endemic Goiter:

(show top 50) (show all 328)
# Title Authors Year
1
Medical geology of endemic goiter in Kalutara, Sri Lanka; distribution and possible causes. ( 28551882 )
2017
2
Endemic goiter and iodine deficiency status among Guinea-Bissau school-age children. ( 29284787 )
2017
3
Incidental Papillary Thyroid Microcarcinoma in an Endemic Goiter Area. ( 26949559 )
2016
4
The Association between Cobalt Deficiency and Endemic Goiter in School-Aged Children. ( 25309789 )
2014
5
Surgical treatment of endemic goiter in a nonhospital setting without general anesthesia in Africa. ( 24728536 )
2014
6
Electron microscopic analysis of an angiosarcoma of the thyroid from a non-Alpine endemic goiter region: A case report and brief review of the literature. ( 25289092 )
2014
7
Role of bamboo-shoot in the pathogenesis of endemic goiter in manipur, north East India. ( 23186959 )
2013
8
Single lobe disease in cases of advanced endemic goiter: a new phenotype. ( 24783020 )
2012
9
State of the art: surgery for endemic goiter. ( 22083604 )
2012
10
Clinicopathological profile, airway management, and outcome in huge multinodular goiters: an institutional experience from an endemic goiter region. ( 22302284 )
2012
11
Thyroid autoimmunity role in the evolution of endemic goiter in rural area, Fars, Iran. ( 21529102 )
2011
12
State of the art: surgery for endemic goiter--a plea for individualizing the extent of resection instead of heading for routine total thyroidectomy. ( 21630080 )
2011
13
Selenium deficiency a factor in endemic goiter persistence in sub-Saharan Africa. ( 21523503 )
2011
14
Endemic goiter--individual risk factors necessitate individual treatment. ( 22006052 )
2011
15
INCAP studies of endemic goiter and its prevention. ( 20461908 )
2010
16
Evidence of endemic goiter and iodine deficiency in a mountainous area of Haiti. ( 19454392 )
2009
17
Etiological factors for the persistence of endemic goiter in selected areas of Siddharthnagar district in Eastern Uttar Pradesh, India. ( 19554805 )
2009
18
The role of thyroid autoantibodies in the etiology of endemic goiter in schoolchildren of Isfahan, Iran. ( 19494708 )
2009
19
Follicular thyroid carcinoma in an iodine-replete endemic goiter region: a prospectively collected, retrospectively analyzed clinical trial. ( 19474675 )
2009
20
Malignancy rates in operated patients with hyperthyroidism in an area of endemic goiter. ( 20302029 )
2009
21
Iodine deficiency and endemic goiter: a national tragedy. ( 18599928 )
2008
22
Endemic goiter in Semirom; there is no difference in vitamin A status between goitrous and nongoitrous children. ( 19155579 )
2008
23
Does fine-needle aspiration cytology optimize the surgical management of thyroid disorders in endemic goiter region? ( 18202924 )
2008
24
Evaluation of endemic goiter prevalence in Bulgarian schoolchildren: results from national strategies for prevention and control of iodine-deficiency disorders. ( 17709907 )
2007
25
Endemic goiter due to thyroglobulin gene abnormality and social ostracism. ( 17446654 )
2007
26
High incidence of tracheomalacia in longstanding goiters: experience from an endemic goiter region. ( 17354028 )
2007
27
The role of iodine in the evolution of thyroid disease in Greece: from endemic goiter to thyroid autoimmunity. ( 17324915 )
2007
28
Clinical importance of solitary thyroid nodule of the thyroid in endemic goiter region. ( 16790952 )
2006
29
Clinical importance of solitary solid nodule of the thyroid in endemic goiter region. ( 16199924 )
2005
30
History of endemic goiter in Croatia: from severe iodine deficiency to iodine sufficiency. ( 16117293 )
2005
31
Prognostic factors of papillary and follicular thyroid cancer: differences in an iodine-replete endemic goiter region. ( 15027890 )
2004
32
Accuracy of preoperative pinhole subtraction single photon emission computed tomography for patients with primary and recurrent hyperparathyroidism in an endemic goiter area. ( 15170543 )
2004
33
Impact of localization studies on feasibility of minimally invasive parathyroidectomy in an endemic goiter region. ( 12691928 )
2003
34
Application of staging systems for differentiated thyroid carcinoma in an endemic goiter region with iodine substitution. ( 12560781 )
2003
35
Fluorine-18-fluorodeoxyglucose positron emission tomography in the preoperative assessment of thyroid nodules in an endemic goiter area. ( 12660642 )
2003
36
Influence of iodine deficiency and iodine prophylaxis on thyroid cancer histotypes and incidence in endemic goiter area. ( 12762644 )
2003
37
Limited sensitivity of parathyroid imaging with (99m)Tc-sestamibi/(123)I subtraction in an endemic goiter area. ( 12215555 )
2002
38
Iodine and selenium deficiency in school-children in an endemic goiter area in Turkey. ( 12199330 )
2002
39
Iodized oil as a complement to iodized salt in schoolchildren in endemic goiter in Romania. ( 12207166 )
2002
40
Endemic goiter in pregnant women: utility of the simplified classification of thyroid size by palpation and urinary iodine as screening tests. ( 12504972 )
2002
41
Iodine deficiency in Calabria: characterization of endemic goiter and analysis of different indicators of iodine status region-wide. ( 11936460 )
2002
42
Insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels of children living in an iodine- and selenium-deficient endemic goiter area. ( 12666822 )
2002
43
Endemic goiter--an update. ( 17018443 )
2002
44
Dietary supplies of iodine and thiocyanate in the etiology of endemic goiter in Tripura. ( 11407152 )
2001
45
Endemic goiter, thiocyanate overload, and selenium status in school-age children. ( 11330518 )
2001
46
Endemic goiter and cretinism: an update on iodine status. ( 11837501 )
2001
47
Changes in serum thyroid hormone levels in newborn calves as a diagnostic index of endemic goiter. ( 11258455 )
2001
48
Minimally invasive open parathyroidectomy in an endemic goiter area: a prospective study. ( 11448396 )
2001
49
Thyroid hormone profile in children with goiter in an endemic goiter area. ( 11305795 )
2001
50
Endemic goiter associated with high iodine intake. ( 11030003 )
2000

Variations for Endemic Goiter

Expression for Endemic Goiter

Search GEO for disease gene expression data for Endemic Goiter.

Pathways for Endemic Goiter

GO Terms for Endemic Goiter

Cellular components related to Endemic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CALCA SERPINA7 TG TPO TSHB

Biological processes related to Endemic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.54 CALCA TG TSHB
2 cell-cell signaling GO:0007267 9.43 CALCA TSHB TSHR
3 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.32 CALCA TSHR
4 hormone-mediated signaling pathway GO:0009755 9.16 TSHB TSHR
5 activation of adenylate cyclase activity GO:0007190 8.96 CALCA TSHR
6 hormone biosynthetic process GO:0042446 8.62 TG TPO

Molecular functions related to Endemic Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CALCA TG TSHB

Sources for Endemic Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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