MCID: END014
MIFTS: 37

Endemic Typhus

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Endemic Typhus

MalaCards integrated aliases for Endemic Typhus:

Name: Endemic Typhus 12 60 15
Murine Typhus 12 60 3
Rickettsia Felis Spotted Fever 12
Endemic Flea-Borne Typhus 74
Cat Flea Rickettsiosis 12
Urban Typhus of Malaya 12
Flea-Borne Typhus 60
Fleaborne Typhus 12
Rat-Flea Typhus 12
Toulon Typhus 12
Urban Typhus 12
Shop Typhus 12

Characteristics:

Orphanet epidemiological data:

60
murine typhus
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050481
ICD10 via Orphanet 35 A75.2
Orphanet 60 ORPHA83315
UMLS 74 C0041472

Summaries for Endemic Typhus

Disease Ontology : 12 A typhus that has material basis in Rickettsia typhi or has material basis in Rickettsia felis, which are transmitted by fleas (Xenopsylla cheopis). The infection has symptom headache, has symptom fever, has symptom chills, has symptom myalgia, has symptom nausea, has symptom vomiting, has symptom cough and has symptom rash.

MalaCards based summary : Endemic Typhus, also known as murine typhus, is related to spotted fever and epidemic typhus. An important gene associated with Endemic Typhus is AFF2 (AF4/FMR2 Family Member 2). The drugs Tocopherol and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and heart.

Related Diseases for Endemic Typhus

Graphical network of the top 20 diseases related to Endemic Typhus:



Diseases related to Endemic Typhus

Symptoms & Phenotypes for Endemic Typhus

Drugs & Therapeutics for Endemic Typhus

Drugs for Endemic Typhus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 196)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tocopherol Approved, Investigational Phase 4 1406-66-2 14986
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 564-25-0 54671203
3
Azithromycin Approved Phase 4 83905-01-5 447043 55185
4
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Not Applicable 1406-16-2
5
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 2,Not Applicable 67-97-0 5280795 6221
6
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
7
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 68-26-8, 22737-96-8, 11103-57-4 9904001 445354
8 Tocotrienol Investigational Phase 4 6829-55-6
9 Vitamins Phase 4,Phase 2,Not Applicable
10 Omega 3 Fatty Acid Phase 4
11 Calciferol Phase 4,Phase 2,Not Applicable
12 Trace Elements Phase 4,Phase 1,Not Applicable
13 Tocopherols Phase 4
14 Bone Density Conservation Agents Phase 4,Not Applicable
15 retinol Phase 4,Not Applicable
16 Nutrients Phase 4,Phase 1,Not Applicable
17 Retinol palmitate Phase 4,Not Applicable
18 Antioxidants Phase 4
19 Micronutrients Phase 4,Phase 1,Not Applicable
20 Protective Agents Phase 4,Phase 1,Not Applicable
21 Tocotrienols Phase 4
22 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable
24 Antimalarials Phase 4,Phase 3,Phase 2,Not Applicable
25 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
26 Immunologic Factors Phase 4,Not Applicable
27 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2,Not Applicable
29 Vaccines Phase 4
30 Antitubercular Agents Phase 4,Phase 1,Phase 2,Not Applicable
31
Adenosine Approved, Investigational Phase 3 58-61-7 60961
32
Regadenoson Approved, Investigational Phase 3 313348-27-5 219024
33
Telithromycin Approved Phase 3 191114-48-4 70789201 5462516
34
Donepezil Approved Phase 3 120014-06-4 3152
35
Tafenoquine Approved, Investigational Phase 3,Phase 2 106635-80-7
36
Primaquine Approved Phase 3,Phase 2 90-34-6 4908
37 Orange Approved Phase 3
38
chloroquine Approved, Investigational, Vet_approved Phase 3,Phase 2 54-05-7 2719
39
Choline Approved, Nutraceutical Phase 3 62-49-7 305
40 Neurotransmitter Agents Phase 3,Not Applicable
41 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
42 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1,Not Applicable
43 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1,Not Applicable
44 Analgesics Phase 3,Phase 2,Phase 1,Not Applicable
45 Gastrointestinal Agents Phase 3,Phase 1,Not Applicable
46 Antimetabolites Phase 3,Not Applicable
47 Nootropic Agents Phase 3
48 Cholinesterase Inhibitors Phase 3
49 Cholinergic Agents Phase 3
50 Anthelmintics Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 101)
# Name Status NCT ID Phase Drugs
1 Effects of Family Work Shop for Children With Developmental Delays Unknown status NCT02523963 Phase 4
2 Oral Nutrition Impact on Tear Film Unknown status NCT01561040 Phase 4
3 The Role of Rapid Diagnostic Tests for Malaria for Targeting of ACTs at Community Level Completed NCT01907672 Phase 4
4 Immunogenicity, Safety and Tolerability of a Trivalent Subunit Inactivated Vaccine in Healthy Subjects 50 Years and Above Completed NCT01867021 Phase 4
5 Scrub Typhus Antibiotic Resistance Trial Recruiting NCT03083197 Phase 4 Doxycycline 7 days;Doxycycline 3 days;Azithromycin 3 days
6 Myocardial Perfusion Assessment With Multidetector Computed Tomography Unknown status NCT00846079 Phase 3
7 Controlled Trial: 5-day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Completed NCT00351182 Phase 3 Telithromycin;Doxycycline
8 Efficacy and Safety Study of Shenwu Capsule Completed NCT01451749 Phase 3 Shenwu Capsule;Donepezil
9 Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax Malaria Completed NCT02216123 Phase 3 Tafenoquine;Tafenoquine Placebo;Chloroquine;Primaquine;Primaquine Placebo
10 Prospective Comparison of 18F-choline PET/CT and 18F-FDG PET/CT in the Initial Work-up of Multiple Myeloma Not yet recruiting NCT03891914 Phase 3 Positron Emission Tomography using 18F-FCH;Positron Emission Tomography using 18F-FDG
11 Sequential HIPEC of Oxaliplatin and Paclitaxel for Gastric Cancer Patients With Peritoneum Metastasis Unknown status NCT01471132 Phase 2 Oxaliplatin;Paclitaxel
12 A Clinical Trial to Evaluate the Safety and Efficacy of Ciprofloxacin in the Treatment of Plague in Humans Unknown status NCT01243437 Phase 2 ciprofloxacin;doxyxcycline
13 Exercise and NutraStem (NT-020): Effects on Stem Cells Completed NCT01847027 Phase 2 NutraStem;Placebo
14 An Intervention to Reduce Inappropriate Prescriptions of Antibiotics for Respiratory Infections in General Practice Completed NCT00272155 Phase 1, Phase 2
15 Ph 2B/3 Tafenoquine (TFQ) Study in Prevention of Vivax Relapse Completed NCT01376167 Phase 2 Chloroquine 600mg;Chloroquine 300mg;Tafenoquine 50mg;Tafenoquine 100mg;Tafenoquine 300mg;Tafenoquine 600mg;Primaquine 15mg;Chloroquine 600mg (Part 2 );Chloroquine 300mg (Part 2 );Tafenoquine 300mg (Part 2);Primaquine 15mg (Part2 )
16 The Nutritional Supplement Phosphatidylserine in Patients With Familial Dysautonomia Recruiting NCT02276716 Phase 2 Phosphatidylserine
17 If Channel Blockade With Ivabradine in Patients With Diastolic Heart Failure Withdrawn NCT00757055 Phase 2 Ivabradine;Placebo
18 Effect of Zinc Carnosine on Intestinal Permeability in Healthy Volunteers Recruiting NCT00149149 Phase 1 Zinc carnosine
19 NaF/FDG PET/MRI in Measuring Response to Radium Ra 223 Dichloride in Patients With Metastatic Hormone-Resistant Prostate Cancer Terminated NCT02429804 Phase 1 Fludeoxyglucose F-18;Fluorine F 18 Sodium Fluoride
20 Effects of Work Shop for Children With Developmental Delays Unknown status NCT02181036 Not Applicable
21 The Functional Status of Anterior Cruciate Ligament Reconstruction (ACLR) Patients at Discharge From Rehabilitation Unknown status NCT03047187
22 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
23 A Study to Evaluate the Impact of Direct and Surrogate Advertising and Compliance With the Bill With the Respect to Sale of Tobacco Products Around Educational Institutes Unknown status NCT01275950 Not Applicable
24 Assessing the Effect of Strengthening Referral of Sick Children From the Private Health Sector and Its Impact on Referral Uptake in Uganda. Unknown status NCT02450630 Not Applicable
25 Stress Adenosine Cardiac Magnetic Resonance (MR) Comparison With Single Photon Emission Computed Tomography (SPECT) Imaging Unknown status NCT00864591
26 Virtual Reality for Panic Disorder With Agoraphobia Unknown status NCT03101332 Not Applicable
27 Comparing Nutritional Status of In-centre Nocturnal Hemodialysis Patients to Conventional Hemodialysis Patients Unknown status NCT02887391
28 IMPACT2: Monitoring Interventions to Improve Artemisinin-based Combination Therapy (ACT) Access and Targeting Unknown status NCT01130155
29 Combination Chemotherapy Followed By Stem Cell Transplant in Treating Young Patients With Progressive or Relapsed Anaplastic Large Cell Lymphoma Unknown status NCT00317408 Not Applicable busulfan;carboplatin;carmustine;cyclosporine;cytarabine;dexamethasone;etoposide phosphate;idarubicin;ifosfamide;leucovorin calcium;lomustine;melphalan;methotrexate;mitoxantrone hydrochloride;prednisolone;thiotepa;vinblastine sulfate;vindesine
30 Impact of Hospital Admission on Patients With Dementia Unknown status NCT02483065
31 Scrub Typhus Pediatric Immunology Study Completed NCT02398162
32 Controlled Trial: 5-day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Completed NCT00568711 Not Applicable doxycycline;rifampin
33 One-stop-shop Study for Treatment of Basal Cell Carcinoma Using Reflectance Confocal Microscopy Completed NCT02285790 Not Applicable
34 Prevalence of Pain Disorders in Employees of French Furniture Shop. Completed NCT03277885
35 Causes of Fever in Bangladeshi Patients Completed NCT02339259
36 Dietary Intervention With Shop Model - SHOPUS Completed NCT01195610 Not Applicable
37 Introducing Rapid Diagnostic Tests Into the Private Health Sector Completed NCT01194557 Not Applicable Lumartem
38 Feasibility and Impact of Malaria Rapid Diagnostic Tests in the African Retail Sector Completed NCT01652365 Not Applicable
39 Adiposity and Airway Inflammation in HIV-Associated Airway Disease Completed NCT02975258
40 Isocyanate Dermal Exposures in Autobody Shops Completed NCT00005552
41 An Interventional Study to Reduce Social Disparities in Diet Quality in the Northern Districts of Marseille Completed NCT02383875 Not Applicable
42 FITShop: Promoting Physical Activity in Black Barbershops Completed NCT01699321 Not Applicable
43 Preoperative Staging of Endometriosis With MRI Completed NCT01939535
44 The Impact of Palm Date Intake on Colon Health Biomarkers Completed NCT02288611 Not Applicable
45 Influence of Light Exposure on Cerebral MAO-A in Seasonal Affective Disorder and Healthy Controls Measured by PET Completed NCT02582398 Not Applicable
46 Role and Effectiveness of Rapid Diagnostic Tests in Home-based Management of Malaria Completed NCT01048801 Not Applicable
47 Examination of Virtual Supermarket (Vmall) as an Assessment of Executive Functions in Children and Adolescents With Acquired Brain Injury Completed NCT00425958
48 The Change Cycle Intervention for Improving Quality of Life in Breast Cancer Survivors Completed NCT01734499 Not Applicable
49 Brazilian Heart-Prevent Meal - A Pilot Randomized Clinical Trial Completed NCT01453166 Not Applicable
50 Virtual Action Planning in Stroke: a Control Rehabilitation Study Completed NCT01365858 Not Applicable

Search NIH Clinical Center for Endemic Typhus

Genetic Tests for Endemic Typhus

Anatomical Context for Endemic Typhus

MalaCards organs/tissues related to Endemic Typhus:

42
Testes, Brain, Heart, Prostate, Colon, Bone, Liver

Publications for Endemic Typhus

Articles related to Endemic Typhus:

(show top 50) (show all 386)
# Title Authors Year
1
Diagnosis of Murine Typhus by Serology in Peninsular Malaysia: A Case Report Where Rickettsial Illnesses, Leptospirosis and Dengue Co-Circulate. ( 30708964 )
2019
2
Characteristics of scrub typhus, murine typhus, and Q fever among elderly patients: Prolonged prothrombin time as a predictor for severity. ( 28709838 )
2019
3
Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015-2017. ( 30882318 )
2019
4
Clinicoepidemiologic characteristics of scrub typhus and murine typhus: A multi-center study in southern Taiwan. ( 31088776 )
2019
5
Laboratory-acquired Scrub Typhus and Murine Typhus Infections: The Argument for a Risk-based Approach to Biosafety Requirements for Orientia tsutsugamushi and Rickettsia typhi Laboratory Activities. ( 30107504 )
2019
6
Murine typhus Presenting with Status Epilepticus. ( 31002931 )
2019
7
Murine typhus in Mexico City: report of an imported case. ( 30864621 )
2019
8
A Prospective, Open-label, Randomized Trial of Doxycycline Versus Azithromycin for the Treatment of Uncomplicated Murine Typhus. ( 30020447 )
2019
9
High Morbidity Due to Murine Typhus Upsurge in Urban Neighborhoods in Central Israel. ( 30761983 )
2019
10
Murine Typhus Mimicking Kawasaki Disease in a Preadolescent Girl. ( 29742650 )
2018
11
Concomitant Plasmodium vivax malaria and murine typhus infection with pulmonary involvement. ( 30567216 )
2018
12
Case Report: Fulminant Murine Typhus Presenting with Status Epilepticus and Multi-Organ Failure: an Autopsy Case and a Review of the Neurologic Presentations of Murine Typhus. ( 29943716 )
2018
13
Murine Typhus with Marked Thrombocytopenia in a Child in Northern Greece and Literature Review. ( 29848847 )
2018
14
A Severe Case of Murine Typhus Presenting With Anemia and Severe Thrombocytopenia. ( 29200167 )
2018
15
Murine Typhus in South Texas Children: An 18-year Review. ( 29465481 )
2018
16
Analysis of Health-Care Charges in Murine Typhus: Need for Improved Clinical Recognition and Diagnostics for Acute Disease. ( 29637877 )
2018
17
Murine Typhus and Hemophagocytic Syndrome. ( 29683952 )
2018
18
An Unusual Presentation of Murine Typhus and Mononucleosis. ( 29788215 )
2018
19
Comparative Study on the Epidemiological Trends and Aspects of Murine Typhus in Korea in the Last Decade (2006-2015). ( 30166809 )
2018
20
Murine typhus associated abducens nerve palsy. ( 30173785 )
2018
21
Murine Typhus: A Life-Threatening Presentation of a Case in Galveston, Texas. ( 30559335 )
2018
22
Severe Murine Typhus Presenting with Acalculous Cholecystitis: A Case Report and Literature Review. ( 28473857 )
2017
23
The Epidemiology and Characteristics of Q fever and Co-infections with Scrub Typhus, Murine Typhus or Leptospirosis in Taiwan: A Nationwide Database Study. ( 27966835 )
2017
24
Murine typhus masquerading as retiform purpura-like rashes. ( 28940672 )
2017
25
Identification of factors for physicians to facilitate early differential diagnosis of scrub typhus, murine typhus, and Q fever from dengue fever in Taiwan. ( 25648664 )
2017
26
Clinical and laboratory characteristics, epidemiology, and outcomes of murine typhus: A systematic review. ( 27983969 )
2017
27
Significance of major international seaports in the distribution of murine typhus in Taiwan. ( 28264003 )
2017
28
Correction: Significance of major international seaports in the distribution of murine typhus in Taiwan. ( 28467406 )
2017
29
Severe interstitial pneumonia due to murine typhus in a patient returning from Bali. ( 28560173 )
2017
30
Acute Febrile Illness and Complications Due to Murine Typhus, Texas, USA1,2. ( 28726607 )
2017
31
State of the art of diagnosis of rickettsial diseases: the use of blood specimens for diagnosis of scrub typhus, spotted fever group rickettsiosis, and murine typhus. ( 27429138 )
2016
32
Spotted Fever Group Rickettsioses and Murine Typhus in a Malaysian Teaching Hospital. ( 27402519 )
2016
33
Opossums and Cat Fleas: New Insights in the Ecology of Murine Typhus in Galveston, Texas. ( 27273642 )
2016
34
Structural features of the O-antigen of Rickettsia typhi, the etiological agent of endemic typhus. ( 26435145 )
2015
35
Increased Nucleosomes and Neutrophil Activation Link to Disease Progression in Patients with Scrub Typhus but Not Murine Typhus in Laos. ( 26317419 )
2015
36
Clinical and Epidemiological Characteristics of Scrub Typhus and Murine Typhus among Hospitalized Patients with Acute Undifferentiated Fever in Northern Vietnam. ( 25778504 )
2015
37
Noneruptive fever revealing murine typhus in a traveler returning from Tunisia. ( 25158857 )
2015
38
Murine typhus, Reunion, France, 2011-2013. ( 25625653 )
2015
39
Epidemiological, clinical and laboratory features of murine typhus in central Tunisia. ( 25687303 )
2015
40
Reemergence of murine typhus in Galveston, Texas, USA, 2013. ( 25695758 )
2015
41
Murine typhus in a liver transplant recipient: report of a first case. ( 25867285 )
2015
42
Round Pneumonia With Murine Typhus After Travel to Indonesia. ( 26171885 )
2015
43
Misdiagnosed murine typhus in a patient with multiple cerebral infarctions and hemorrhage: a case report. ( 26223226 )
2015
44
Case report: probable murine typhus at Joint Base San Antonio, TX. ( 26295976 )
2015
45
An Unusual Cutaneous Manifestation in a Patient with Murine Typhus. ( 26416115 )
2015
46
Bilateral optic atrophy in endemic typhus. ( 25103667 )
2014
47
Myositis in a child with murine typhus. ( 24757508 )
2014
48
Pregnancy outcome in relation to treatment of murine typhus and scrub typhus infection: a fever cohort and a case series analysis. ( 25412503 )
2014
49
Murine typhus as a cause of cognitive impairment: case report and a review of the literature. ( 24321542 )
2014
50
Loop-mediated isothermal amplification for Rickettsia typhi (the causal agent of murine typhus): problems with diagnosis at the limit of detection. ( 24371248 )
2014

Variations for Endemic Typhus

Expression for Endemic Typhus

Search GEO for disease gene expression data for Endemic Typhus.

Pathways for Endemic Typhus

GO Terms for Endemic Typhus

Sources for Endemic Typhus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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