MCID: END014
MIFTS: 36

Endemic Typhus

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Endemic Typhus

MalaCards integrated aliases for Endemic Typhus:

Name: Endemic Typhus 12 60 15
Murine Typhus 12 60
Rickettsia Felis Spotted Fever 12
Endemic Flea-Borne Typhus 74
Cat Flea Rickettsiosis 12
Urban Typhus of Malaya 12
Flea-Borne Typhus 60
Fleaborne Typhus 12
Rat-Flea Typhus 12
Toulon Typhus 12
Urban Typhus 12
Shop Typhus 12

Characteristics:

Orphanet epidemiological data:

60
murine typhus
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050481
ICD10 via Orphanet 35 A75.2
Orphanet 60 ORPHA83315
UMLS 74 C0041472

Summaries for Endemic Typhus

Disease Ontology : 12 A typhus that has material basis in Rickettsia typhi or has material basis in Rickettsia felis, which are transmitted by fleas (Xenopsylla cheopis). The infection has symptom headache, has symptom fever, has symptom chills, has symptom myalgia, has symptom nausea, has symptom vomiting, has symptom cough and has symptom rash.

MalaCards based summary : Endemic Typhus, also known as murine typhus, is related to spotted fever and epidemic typhus. An important gene associated with Endemic Typhus is AFF2 (AF4/FMR2 Family Member 2). The drugs Tocopherol and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and breast.

Related Diseases for Endemic Typhus

Diseases related to Endemic Typhus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 spotted fever 29.7 AFF2 PLEKHG4
2 epidemic typhus 11.9
3 scrub typhus 11.9
4 leptospirosis 10.2
5 rocky mountain spotted fever 10.2
6 plague 10.1
7 dengue virus 10.0
8 dengue disease 10.0
9 thrombocytopenia 10.0
10 endocarditis 10.0
11 meningoencephalitis 10.0
12 boutonneuse fever 10.0
13 status epilepticus 10.0
14 cholecystitis 10.0
15 3-methylglutaconic aciduria, type iii 9.9
16 q fever 9.9
17 papilledema 9.9
18 optic nerve disease 9.9
19 pharyngitis 9.9
20 pneumonia 9.9
21 neuropathy 9.9
22 myositis 9.8
23 malaria 9.8
24 kawasaki disease 9.8
25 riboflavin deficiency 9.8
26 deficiency anemia 9.8
27 african tick-bite fever 9.8
28 bubonic plague 9.8
29 queensland tick typhus 9.8
30 brucellosis 9.8
31 respiratory failure 9.8
32 lymphocytic choriomeningitis 9.8
33 aseptic meningitis 9.8
34 plasmodium vivax malaria 9.8
35 acalculous cholecystitis 9.8
36 purpura 9.8
37 meningitis 9.8
38 pulmonary embolism 9.8
39 encephalopathy 9.8
40 headache 9.8
41 indian tick typhus 9.8 AFF2 PLEKHG4
42 flinders island spotted fever 9.7 AFF2 PLEKHG4
43 japanese spotted fever 9.6 AFF2 PLEKHG4

Graphical network of the top 20 diseases related to Endemic Typhus:



Diseases related to Endemic Typhus

Symptoms & Phenotypes for Endemic Typhus

Drugs & Therapeutics for Endemic Typhus

Drugs for Endemic Typhus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 196)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tocopherol Approved, Investigational Phase 4 1406-66-2 14986
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 564-25-0 54671203
3
Azithromycin Approved Phase 4 83905-01-5 55185 447043
4
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
5
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Not Applicable 1406-16-2
6
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 2,Not Applicable 67-97-0 5280795 6221
7
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
8 Tocotrienol Investigational Phase 4 6829-55-6
9 Antioxidants Phase 4
10 Calciferol Phase 4,Phase 2,Not Applicable
11 Bone Density Conservation Agents Phase 4,Not Applicable
12 Tocopherols Phase 4
13 Retinol palmitate Phase 4,Not Applicable
14 Nutrients Phase 4,Phase 1,Not Applicable
15 retinol Phase 4,Not Applicable
16 Trace Elements Phase 4,Phase 1,Not Applicable
17 Vitamins Phase 4,Phase 2,Not Applicable
18 Tocotrienols Phase 4
19 Micronutrients Phase 4,Phase 1,Not Applicable
20 Omega 3 Fatty Acid Phase 4
21 Protective Agents Phase 4,Phase 1,Not Applicable
22 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable
23 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2,Not Applicable
24 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
25 Antimalarials Phase 4,Phase 3,Phase 2,Not Applicable
26 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Immunologic Factors Phase 4,Not Applicable
29 Antitubercular Agents Phase 4,Phase 1,Phase 2,Not Applicable
30 Vaccines Phase 4
31
Adenosine Approved, Investigational Phase 3 58-61-7 60961
32
Regadenoson Approved, Investigational Phase 3 313348-27-5 219024
33
Telithromycin Approved Phase 3 191114-48-4 70789201 5462516
34
Donepezil Approved Phase 3 120014-06-4 3152
35
Primaquine Approved Phase 3,Phase 2 90-34-6 4908
36
chloroquine Approved, Investigational, Vet_approved Phase 3,Phase 2 54-05-7 2719
37 Orange Approved Phase 3
38
Tafenoquine Approved, Investigational Phase 3,Phase 2 106635-80-7
39
Choline Approved, Nutraceutical Phase 3 62-49-7 305
40 Neurotransmitter Agents Phase 3,Not Applicable
41 Antimetabolites Phase 3,Not Applicable
42 Gastrointestinal Agents Phase 3,Phase 1,Not Applicable
43 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 2,Phase 1
44 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1,Not Applicable
45 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1,Not Applicable
46 Analgesics, Non-Narcotic Phase 3,Phase 2,Phase 1
47 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
48 Analgesics Phase 3,Phase 2,Phase 1,Not Applicable
49 Fluorodeoxyglucose F18 Phase 3,Phase 1
50 Hypolipidemic Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 99)
# Name Status NCT ID Phase Drugs
1 Effects of Family Work Shop for Children With Developmental Delays Unknown status NCT02523963 Phase 4
2 Oral Nutrition Impact on Tear Film Unknown status NCT01561040 Phase 4
3 Scrub Typhus Antibiotic Resistance Trial Recruiting NCT03083197 Phase 4 Doxycycline 7 days;Doxycycline 3 days;Azithromycin 3 days
4 The Role of Rapid Diagnostic Tests for Malaria for Targeting of ACTs at Community Level Completed NCT01907672 Phase 4
5 Immunogenicity, Safety and Tolerability of a Trivalent Subunit Inactivated Vaccine in Healthy Subjects 50 Years and Above Completed NCT01867021 Phase 4
6 Myocardial Perfusion Assessment With Multidetector Computed Tomography Unknown status NCT00846079 Phase 3
7 Controlled Trial: 5-day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Completed NCT00351182 Phase 3 Telithromycin;Doxycycline
8 Prospective Comparison of 18F-choline PET/CT and 18F-FDG PET/CT in the Initial Work-up of Multiple Myeloma Not yet recruiting NCT03891914 Phase 3 Positron Emission Tomography using 18F-FCH;Positron Emission Tomography using 18F-FDG
9 Efficacy and Safety Study of Shenwu Capsule Completed NCT01451749 Phase 3 Shenwu Capsule;Donepezil
10 Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax Malaria Completed NCT02216123 Phase 3 Tafenoquine;Tafenoquine Placebo;Chloroquine;Primaquine;Primaquine Placebo
11 Sequential HIPEC of Oxaliplatin and Paclitaxel for Gastric Cancer Patients With Peritoneum Metastasis Unknown status NCT01471132 Phase 2 Oxaliplatin;Paclitaxel
12 A Clinical Trial to Evaluate the Safety and Efficacy of Ciprofloxacin in the Treatment of Plague in Humans Unknown status NCT01243437 Phase 2 ciprofloxacin;doxyxcycline
13 Exercise and NutraStem (NT-020): Effects on Stem Cells Completed NCT01847027 Phase 2 NutraStem;Placebo
14 The Nutritional Supplement Phosphatidylserine in Patients With Familial Dysautonomia Recruiting NCT02276716 Phase 2 Phosphatidylserine
15 If Channel Blockade With Ivabradine in Patients With Diastolic Heart Failure Withdrawn NCT00757055 Phase 2 Ivabradine;Placebo
16 An Intervention to Reduce Inappropriate Prescriptions of Antibiotics for Respiratory Infections in General Practice Completed NCT00272155 Phase 1, Phase 2
17 Ph 2B/3 Tafenoquine (TFQ) Study in Prevention of Vivax Relapse Completed NCT01376167 Phase 2 Chloroquine 600mg;Chloroquine 300mg;Tafenoquine 50mg;Tafenoquine 100mg;Tafenoquine 300mg;Tafenoquine 600mg;Primaquine 15mg;Chloroquine 600mg (Part 2 );Chloroquine 300mg (Part 2 );Tafenoquine 300mg (Part 2);Primaquine 15mg (Part2 )
18 Effect of Zinc Carnosine on Intestinal Permeability in Healthy Volunteers Unknown status NCT00149149 Phase 1 Zinc carnosine
19 NaF/FDG PET/MRI in Measuring Response to Radium Ra 223 Dichloride in Patients With Metastatic Hormone-Resistant Prostate Cancer Terminated NCT02429804 Phase 1 Fludeoxyglucose F-18;Fluorine F 18 Sodium Fluoride
20 Effects of Work Shop for Children With Developmental Delays Unknown status NCT02181036 Not Applicable
21 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
22 A Study to Evaluate the Impact of Direct and Surrogate Advertising and Compliance With the Bill With the Respect to Sale of Tobacco Products Around Educational Institutes Unknown status NCT01275950 Not Applicable
23 Assessing the Effect of Strengthening Referral of Sick Children From the Private Health Sector and Its Impact on Referral Uptake in Uganda. Unknown status NCT02450630 Not Applicable
24 Stress Adenosine Cardiac Magnetic Resonance (MR) Comparison With Single Photon Emission Computed Tomography (SPECT) Imaging Unknown status NCT00864591
25 Virtual Reality for Panic Disorder With Agoraphobia Unknown status NCT03101332 Not Applicable
26 Comparing Nutritional Status of In-centre Nocturnal Hemodialysis Patients to Conventional Hemodialysis Patients Unknown status NCT02887391
27 IMPACT2: Monitoring Interventions to Improve Artemisinin-based Combination Therapy (ACT) Access and Targeting Unknown status NCT01130155
28 Combination Chemotherapy Followed By Stem Cell Transplant in Treating Young Patients With Progressive or Relapsed Anaplastic Large Cell Lymphoma Unknown status NCT00317408 Not Applicable busulfan;carboplatin;carmustine;cyclosporine;cytarabine;dexamethasone;etoposide phosphate;idarubicin;ifosfamide;leucovorin calcium;lomustine;melphalan;methotrexate;mitoxantrone hydrochloride;prednisolone;thiotepa;vinblastine sulfate;vindesine
29 Impact of Hospital Admission on Patients With Dementia Unknown status NCT02483065
30 Scrub Typhus RDT Study Active, not recruiting NCT03269266
31 Scrub Typhus Infection Induced Cardiovascular Disease Recruiting NCT03274869
32 Scrub Typhus Pediatric Immunology Study Completed NCT02398162
33 The Clinical Epidemiology of Scrub Typhus in Humans, Chiggers and Rodents Active, not recruiting NCT02876367
34 Effects of Family Work Shop for Children With Developmental Delays: a Randomized Trial Not yet recruiting NCT03209453 Not Applicable
35 Eschar Investigations in Scrub Typhus Recruiting NCT02915861
36 Controlled Trial: 5-day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Completed NCT00568711 Not Applicable doxycycline;rifampin
37 One-stop-shop Study for Treatment of Basal Cell Carcinoma Using Reflectance Confocal Microscopy Completed NCT02285790 Not Applicable
38 Prevalence of Pain Disorders in Employees of French Furniture Shop. Completed NCT03277885
39 Causes of Fever in Bangladeshi Patients Completed NCT02339259
40 Dietary Intervention With Shop Model - SHOPUS Completed NCT01195610 Not Applicable
41 Introducing Rapid Diagnostic Tests Into the Private Health Sector Completed NCT01194557 Not Applicable Lumartem
42 Feasibility and Impact of Malaria Rapid Diagnostic Tests in the African Retail Sector Completed NCT01652365 Not Applicable
43 C-arm Cone Beam CT Perfusion Guided Cerebrovascular Interventions Recruiting NCT03232151 Not Applicable
44 Adiposity and Airway Inflammation in HIV-Associated Airway Disease Completed NCT02975258
45 The Functional Status of Anterior Cruciate Ligament Reconstruction (ACLR) Patients at Discharge From Rehabilitation Not yet recruiting NCT03047187
46 Reducing Anemia Through Food Fortification at Scale Enrolling by invitation NCT03573570 Not Applicable
47 Rickettsiae in Myanmar Not yet recruiting NCT03847870
48 Isocyanate Dermal Exposures in Autobody Shops Completed NCT00005552
49 Stop-Service to Obviously-Impaired Patrons Recruiting NCT03608787 Not Applicable
50 An Interventional Study to Reduce Social Disparities in Diet Quality in the Northern Districts of Marseille Completed NCT02383875 Not Applicable

Search NIH Clinical Center for Endemic Typhus

Genetic Tests for Endemic Typhus

Anatomical Context for Endemic Typhus

MalaCards organs/tissues related to Endemic Typhus:

42
Testes, Brain, Breast, Heart, Prostate, Colon, Bone

Publications for Endemic Typhus

Articles related to Endemic Typhus:

(show top 50) (show all 274)
# Title Authors Year
1
Diagnosis of Murine Typhus by Serology in Peninsular Malaysia: A Case Report Where Rickettsial Illnesses, Leptospirosis and Dengue Co-Circulate. ( 30708964 )
2019
2
Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015-2017. ( 30882318 )
2019
3
High Morbidity Due to Murine Typhus Upsurge in Urban Neighborhoods in Central Israel. ( 30761983 )
2019
4
Murine typhus in Mexico City: report of an imported case. ( 30864621 )
2019
5
Murine Typhus Mimicking Kawasaki Disease in a Preadolescent Girl. ( 29742650 )
2018
6
Concomitant Plasmodium vivax malaria and murine typhus infection with pulmonary involvement. ( 30567216 )
2018
7
Laboratory-acquired scrub typhus and murine typhus infections: The argument for risk-based approach to biosafety requirements for Orientia tsutsugamushi and Rickettsia typhi laboratory activities. ( 30107504 )
2018
8
Murine Typhus with Marked Thrombocytopenia in a Child in Northern Greece and Literature Review. ( 29848847 )
2018
9
A Severe Case of Murine Typhus Presenting With Anemia and Severe Thrombocytopenia. ( 29200167 )
2018
10
Murine Typhus in South Texas Children: An 18-year Review. ( 29465481 )
2018
11
Analysis of Health-Care Charges in Murine Typhus: Need for Improved Clinical Recognition and Diagnostics for Acute Disease. ( 29637877 )
2018
12
Murine Typhus and Hemophagocytic Syndrome. ( 29683952 )
2018
13
An Unusual Presentation of Murine Typhus and Mononucleosis. ( 29788215 )
2018
14
A prospective, open-label, randomized trial of doxycycline versus azithromycin for the treatment of uncomplicated murine typhus. ( 30020447 )
2018
15
Comparative Study on the Epidemiological Trends and Aspects of Murine Typhus in Korea in the Last Decade (2006-2015). ( 30166809 )
2018
16
Murine typhus associated abducens nerve palsy. ( 30173785 )
2018
17
Murine Typhus: A Life-Threatening Presentation of a Case in Galveston, Texas. ( 30559335 )
2018
18
Significance of major international seaports in the distribution of murine typhus in Taiwan. ( 28264003 )
2017
19
Correction: Significance of major international seaports in the distribution of murine typhus in Taiwan. ( 28467406 )
2017
20
Severe interstitial pneumonia due to murine typhus in a patient returning from Bali. ( 28560173 )
2017
21
Acute Febrile Illness and Complications Due to Murine Typhus, Texas, USA1,2. ( 28726607 )
2017
22
Opossums and Cat Fleas: New Insights in the Ecology of Murine Typhus in Galveston, Texas. ( 27273642 )
2016
23
Structural features of the O-antigen of Rickettsia typhi, the etiological agent of endemic typhus. ( 26435145 )
2015
24
Round Pneumonia With Murine Typhus After Travel to Indonesia. ( 26171885 )
2015
25
Misdiagnosed murine typhus in a patient with multiple cerebral infarctions and hemorrhage: a case report. ( 26223226 )
2015
26
Case report: probable murine typhus at Joint Base San Antonio, TX. ( 26295976 )
2015
27
Bilateral optic atrophy in endemic typhus. ( 25103667 )
2014
28
Myositis in a child with murine typhus. ( 24757508 )
2014
29
Pregnancy outcome in relation to treatment of murine typhus and scrub typhus infection: a fever cohort and a case series analysis. ( 25412503 )
2014
30
Murine typhus associated with Parinaud's oculoglandular syndrome in 2 children. ( 24853542 )
2014
31
Severe murine typhus with pulmonary system involvement. ( 25062435 )
2014
32
Murine typhus in elderly patients: a prospective study of 49 patients. ( 25119441 )
2014
33
Murine Typhus: Clinical and epidemiological aspects. ( 24893060 )
2012
34
A cluster of pediatric endemic typhus cases in Orange County, California. ( 21298850 )
2011
35
Postinfectious optic neuropathy in endemic typhus. ( 21897295 )
2011
36
Endemic typhus (murine typhus) in an 18 year old Libyan adult. ( 19842415 )
2009
37
Murine typhus, Algeria. ( 18394297 )
2008
38
Structural features of lipopolysaccharide from Rickettsia typhi: the causative agent of endemic typhus. ( 16481524 )
2005
39
Acute pharyngitis: an unusual presentation of acute endemic typhus. ( 16213963 )
2005
40
Murine (endemic) typhus in Brazil: case report and review. ( 15517036 )
2004
41
Endemic typhus in Singapore--a re-emerging infectious disease? ( 11989574 )
2001
42
The increasing prevalence of Endemic Typhus in Kuala Lumpur and an evaluation of a diagnostic ELISA dot test for the detection of antibodies to Rickettsia typhi. ( 11063173 )
2000
43
Murine typhus in Mexico City. ( 10748896 )
2000
44
Murine typhus in South Texas children. ( 10877169 )
2000
45
Murine typhus in metropolitan Perth. ( 10026693 )
1999
46
Murine typhus as a common cause of fever of intermediate duration: a 17-year study in the south of Spain. ( 10219934 )
1999
47
Scrub and murine typhus among Dutch travellers. ( 10885849 )
1999
48
Murine typhus presenting as subacute meningoencephalitis. ( 9776466 )
1998
49
Imported rickettsioses: think of murine typhus. ( 9566648 )
1998
50
Septic shock and multiorganic failure in murine typhus. ( 9629982 )
1998

Variations for Endemic Typhus

Expression for Endemic Typhus

Search GEO for disease gene expression data for Endemic Typhus.

Pathways for Endemic Typhus

GO Terms for Endemic Typhus

Sources for Endemic Typhus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....