MCID: END014
MIFTS: 32

Endemic Typhus

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Endemic Typhus

MalaCards integrated aliases for Endemic Typhus:

Name: Endemic Typhus 12 58 15
Murine Typhus 12 58 3
Rickettsia Felis Spotted Fever 12
Endemic Flea-Borne Typhus 70
Cat Flea Rickettsiosis 12
Urban Typhus of Malaya 12
Flea-Borne Typhus 58
Fleaborne Typhus 12
Rat-Flea Typhus 12
Toulon Typhus 12
Urban Typhus 12
Shop Typhus 12

Characteristics:

Orphanet epidemiological data:

58
murine typhus
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050481
ICD10 via Orphanet 33 A75.2
Orphanet 58 ORPHA83315
UMLS 70 C0041472

Summaries for Endemic Typhus

CDC : 3 Typhus fevers are a group of diseases caused by bacteria that are spread to humans by fleas, lice, and chiggers. Typhus fevers include scrub typhus, murine typhus, and epidemic typhus. Chiggers spread scrub typhus, fleas spread murine typhus, and body lice spread epidemic typhus. The most common symptoms are fever, headaches, and sometimes rash.

MalaCards based summary : Endemic Typhus, also known as murine typhus, is related to chlamydia and neuroretinitis. An important gene associated with Endemic Typhus is AFF2 (AF4/FMR2 Family Member 2). The drugs carbamide peroxide and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and endothelial.

Disease Ontology : 12 A typhus that has material basis in Rickettsia typhi or has material basis in Rickettsia felis, which are transmitted by fleas (Xenopsylla cheopis). The infection has symptom headache, has symptom fever, has symptom chills, has symptom myalgia, has symptom nausea, has symptom vomiting, has symptom cough and has symptom rash.

Wikipedia : 73 Murine typhus, also known as endemic typhus or flea-borne typhus, is a form of typhus transmitted by... more...

Related Diseases for Endemic Typhus

Diseases related to Endemic Typhus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 chlamydia 30.2 HTRA1 HSPD1 CRP
2 neuroretinitis 30.2 CS CRP
3 queensland tick typhus 30.1 PLEKHG4 CS
4 boutonneuse fever 30.0 SPTBN2 PPP1R14A PLEKHG4 CS AFF2
5 endocarditis 30.0 HTRA1 HSPD1 CRP
6 ornithosis 30.0 HTRA1 CRP
7 bacterial infectious disease 29.8 HSPD1 H2AC18 CRP
8 disease by infectious agent 29.7 HSPD1 H2AC18 CRP
9 spotted fever 29.5 SPTBN2 PPP1R14A PLEKHG4 HTRA1 CS AFF2
10 epidemic typhus 29.5 ST20-MTHFS SPTBN2 PPP1R14A PLEKHG4 HTRA1 HSPD1
11 brill-zinsser disease 29.3 SPTBN2 PLEKHG4 GLRX5 AFF2
12 cat-scratch disease 29.2 PPP1R14A PCDHGB7 HTRA1 HSPD1 CS CRP
13 rocky mountain spotted fever 28.8 SPTBN2 PPP1R14A PLEKHG4 PCDHGB7 HTRA1 HSPD1
14 leptospirosis 10.4
15 thrombocytopenia 10.3
16 tungiasis 10.3 PPP1R14A AFF2
17 exanthem 10.3
18 inclusion conjunctivitis 10.2 HTRA1 HSPD1
19 flinders island spotted fever 10.2 PLEKHG4 AFF2
20 campylobacteriosis 10.2 HTRA1 HSPD1
21 spinocerebellar ataxia 18 10.2 SPTBN2 PLEKHG4
22 aseptic meningitis 10.2
23 dengue disease 10.2
24 plague 10.2
25 cerebellar ataxia type 9 10.2 SPTBN2 PLEKHG4
26 spinocerebellar ataxia 30 10.2 SPTBN2 PLEKHG4
27 meningoencephalitis 10.2
28 cholecystitis 10.2
29 acute kidney failure 10.2
30 opportunistic bacterial infectious disease 10.2 HSPD1 CRP
31 nocardiosis 10.2 HSPD1 CRP
32 paracoccidioidomycosis 10.2
33 uveitis 10.2
34 sporotrichosis 10.2
35 herpes simplex 10.2
36 bacterial conjunctivitis 10.2
37 basidiobolomycosis 10.1 HSPD1 CRP
38 tenosynovitis 10.1 HSPD1 CRP
39 cervical adenitis 10.1 HSPD1 CRP
40 whipple disease 10.1 HSPD1 CRP
41 salpingitis 10.1 HSPD1 CRP
42 chlamydia pneumonia 10.1 HSPD1 CRP
43 orchitis 10.1 H2AC18 CRP
44 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2 10.1 HTRA1 CRP
45 critical illness polyneuropathy 10.1 CS CRP
46 urethritis 10.1 HSPD1 CRP
47 inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 2 10.1 HSPD1 H2AC18 CS
48 relapsing fever 10.1 HSPD1 CRP
49 primary systemic mycosis 10.1 HSPD1 CRP
50 actinomycosis 10.1 H2AC18 CRP

Graphical network of the top 20 diseases related to Endemic Typhus:



Diseases related to Endemic Typhus

Symptoms & Phenotypes for Endemic Typhus

Drugs & Therapeutics for Endemic Typhus

Drugs for Endemic Typhus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
carbamide peroxide Approved 124-43-6
2 Immunoglobulins
3 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Background Seroprevalence of Rickettsial Infections in Myanmar Completed NCT03847870

Search NIH Clinical Center for Endemic Typhus

Genetic Tests for Endemic Typhus

Anatomical Context for Endemic Typhus

MalaCards organs/tissues related to Endemic Typhus:

40
Kidney, T Cells, Endothelial, Bone Marrow, Bone, Liver, Brain

Publications for Endemic Typhus

Articles related to Endemic Typhus:

(show top 50) (show all 788)
# Title Authors PMID Year
1
Murine Typhus in 5 Children Hospitalized for Multisystem Inflammatory Syndrome in Children. 61
33431429 2021
2
Seroprevalence of Scrub Typhus, Murine Typhus and Spotted Fever Group in North Korean Refugees. 61
33676004 2021
3
Sunbathing, a possible risk factor of murine typhus infection in Greece. 61
33711035 2021
4
Current tools for the diagnosis and detection of spotted fever group Rickettsia. 61
33713627 2021
5
Amplicon-Based Next Generation Sequencing for Rapid Identification of Rickettsia and Ectoparasite Species from Entomological Surveillance in Thailand. 61
33669463 2021
6
Urban foci of murine typhus involving cat fleas (Ctenocephalides felis felis) collected from opossums in Mexico City. 61
33280264 2021
7
Murine Typhus in Canary Islands, Spain, 1999-2015. 61
33496241 2021
8
Murine Typhus Infection in Pregnancy: Case Series and Literature Review. 61
33670581 2021
9
Describing fine spatiotemporal dynamics of rat fleas in an insular ecosystem enlightens abiotic drivers of murine typhus incidence in humans. 61
33600454 2021
10
Murine typhus presenting as pseudotumor cerebri. 61
33529597 2021
11
Manifestations and Management of Flea-Borne Rickettsioses. 61
33574726 2021
12
Rickettsiae exposure related to habitats of the oriental house rat (Rattus tanezumi, Temminck, 1844) in Salaya suburb, Thailand. 61
32793413 2020
13
Murine Typhus Outbreak Presenting as Multisystem Inflammatory Syndrome in Children During SARS-CoV-2 Pandemic. 61
33060516 2020
14
Murine Typhus Presenting With Mucosal Involvement. 61
33269795 2020
15
Murine typhus mistaken for COVID-19 in a young man. 61
33148588 2020
16
The Isolation of Orientia tsutsugamushi and Rickettsia typhi from Human Blood through Mammalian Cell Culture: a Descriptive Series of 3,227 Samples and Outcomes in the Lao People's Democratic Republic. 61
32999008 2020
17
Flea-borne Rickettsia species in fleas, Caldas department, Colombia. 61
33175711 2020
18
A Brief History of the Major Rickettsioses in the Asia-Australia-Pacific Region: A Capstone Review for the Special Issue of TMID. 61
33121158 2020
19
Typhus Group Rickettsiosis, Brazilian Amazon. 61
32818424 2020
20
A systematic review of the untreated mortality of murine typhus. 61
32925913 2020
21
Case Report: Renal Failure due to Focal Segmental Glomerulosclerosis in a Patient with Murine Typhus. 61
32588799 2020
22
Two cases of uveitis associated with severe transaminitis during a Rickettsia typhi outbreak in Los Angeles County. 61
32715155 2020
23
What's eating you? oriental rat flea (Xenopsylla cheopis). 61
33104121 2020
24
Serosurvey of IgG Antibodies against Bartonella henselae and Rickettsia typhi in the Population of Attica, Greece. 61
32947795 2020
25
Measles or Not Measles? That Is the Question! 61
32818145 2020
26
Selection of Diagnostic Cutoffs for Murine Typhus IgM and IgG Immunofluorescence Assay: A Systematic Review. 61
32274984 2020
27
Risk Factors for Scrub Typhus, Murine Typhus, and Spotted Fever Seropositivity in Urban Areas, Rural Plains, and Peri-Forest Hill Villages in South India: A Cross-Sectional Study. 61
32458785 2020
28
Murine typhus. How does it affect us in the 21st century? The epidemiology of inpatients in Spain (1997-2015). 61
32353550 2020
29
Circulation of Rickettsia species and rickettsial endosymbionts among small mammals and their ectoparasites in Eastern Slovakia. 61
32382991 2020
30
The temporal dynamics of humoral immunity to Rickettsia typhi infection in murine typhus patients. 61
31678231 2020
31
A chromosome-level assembly of the cat flea genome uncovers rampant gene duplication and genome size plasticity. 61
32560686 2020
32
Risk1, a Phosphatidylinositol 3-Kinase Effector, Promotes Rickettsia typhi Intracellular Survival. 61
32546622 2020
33
Trends in clinical diagnoses of typhus group rickettsioses among a large U.S. insurance claims database. 61
31984654 2020
34
Serum C-reactive protein and procalcitonin values in acute Q fever, scrub typhus, and murine typhus. 61
32398008 2020
35
Rise in Murine Typhus in Galveston County, Texas, USA, 2018. 61
32310080 2020
36
The epidemiology, characteristics and outbreaks of human leptospirosis and the association with animals in Taiwan, 2007-2014: A nationwide database study. 61
31916706 2020
37
Comparison of Commercial Enzyme-Linked Immunosorbent Assay and Immunofluorescence Assay for Diagnosis of Acute Rickettsia typhi Infections. 61
31448989 2020
38
Emergence of murine typhus in La Réunion, France, 2012-2017. 61
31387814 2020
39
Climate factors driven typhus group rickettsiosis incidence dynamics in Xishuangbanna Dai autonomous prefecture of Yunnan province in China, 2005-2017. 61
31915005 2020
40
Fatal murine typhus with hemophagocytic lymphohistiocytosis in a child. 61
33331518 2020
41
Successful Detection of Unrecognized Rickettsia typhi in Pregnancy Using Cell-Free Next-Generation Sequencing. 61
32547799 2020
42
The Trick of the Hedgehog: Case Report and Short Review About Archaeopsylla erinacei (Siphonaptera: Pulicidae) in Human Health. 61
31595296 2020
43
Clinicoepidemiologic characteristics of scrub typhus and murine typhus: A multi-center study in southern Taiwan. 61
31088776 2019
44
Rickettsiae Within the Fleas of Feral Cats in Galveston, Texas. 61
30835649 2019
45
What's eating you? cat flea (Ctenocephalides felis) revisited. 61
31675400 2019
46
Differentiation of Rickettsia felis and Rickettsia felis-Like Organisms via Restriction Fragment Length Polymorphism Analysis. 61
31021302 2019
47
Development of multiplex PCR for neglected infectious diseases. 61
31283768 2019
48
Seroprevalence of typhus group and spotted fever group Rickettsia exposures on Reunion island. 61
31288833 2019
49
First description of a clinical case of murine typhus in Campeche, Mexico. 61
31188917 2019
50
Murine typhus presenting with status epilepticus. 61
31002931 2019

Variations for Endemic Typhus

Expression for Endemic Typhus

Search GEO for disease gene expression data for Endemic Typhus.

Pathways for Endemic Typhus

GO Terms for Endemic Typhus

Sources for Endemic Typhus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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