MCID: END014
MIFTS: 33

Endemic Typhus

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Endemic Typhus

MalaCards integrated aliases for Endemic Typhus:

Name: Endemic Typhus 12 59 15
Murine Typhus 12 59 3
Rickettsia Felis Spotted Fever 12
Endemic Flea-Borne Typhus 73
Cat Flea Rickettsiosis 12
Urban Typhus of Malaya 12
Flea-Borne Typhus 59
Fleaborne Typhus 12
Rat-Flea Typhus 12
Toulon Typhus 12
Urban Typhus 12
Shop Typhus 12

Characteristics:

Orphanet epidemiological data:

59
murine typhus
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050481
Orphanet 59 ORPHA83315
ICD10 via Orphanet 34 A75.2
UMLS 73 C0041472

Summaries for Endemic Typhus

Disease Ontology : 12 A typhus that has material basis in Rickettsia typhi or has material basis in Rickettsia felis, which are transmitted by fleas (Xenopsylla cheopis). The infection has symptom headache, has symptom fever, has symptom chills, has symptom myalgia, has symptom nausea, has symptom vomiting, has symptom cough and has symptom rash.

MalaCards based summary : Endemic Typhus, also known as murine typhus, is related to spotted fever and scrub typhus. An important gene associated with Endemic Typhus is AFF2 (AF4/FMR2 Family Member 2). The drugs Tocopherol and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and kidney.

Related Diseases for Endemic Typhus

Diseases related to Endemic Typhus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 spotted fever 30.0 AFF2 PLEKHG4
2 scrub typhus 11.8
3 epidemic typhus 11.5
4 leptospirosis 10.2
5 rocky mountain spotted fever 10.1
6 plague 10.0
7 dengue virus 10.0
8 dengue disease 10.0
9 thrombocytopenia 10.0
10 endocarditis 10.0
11 meningoencephalitis 10.0
12 boutonneuse fever 10.0
13 status epilepticus 10.0
14 cholecystitis 10.0
15 indian tick typhus 9.9 AFF2 PLEKHG4
16 3-methylglutaconic aciduria, type iii 9.9
17 q fever 9.9
18 papilledema 9.9
19 optic nerve disease 9.9
20 pharyngitis 9.9
21 pneumonia 9.9
22 neuropathy 9.9
23 flinders island spotted fever 9.9 AFF2 PLEKHG4
24 myositis 9.8
25 kawasaki disease 9.8
26 riboflavin deficiency 9.8
27 african tick-bite fever 9.8
28 bubonic plague 9.8
29 queensland tick typhus 9.8
30 brucellosis 9.8
31 respiratory failure 9.8
32 lymphocytic choriomeningitis 9.8
33 aseptic meningitis 9.8
34 acalculous cholecystitis 9.8
35 purpura 9.8
36 meningitis 9.8
37 pulmonary embolism 9.8
38 encephalopathy 9.8
39 headache 9.8
40 japanese spotted fever 9.8 AFF2 PLEKHG4

Graphical network of the top 20 diseases related to Endemic Typhus:



Diseases related to Endemic Typhus

Symptoms & Phenotypes for Endemic Typhus

Drugs & Therapeutics for Endemic Typhus

Drugs for Endemic Typhus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 191)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tocopherol Approved, Investigational Phase 4 1406-66-2 14986
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 564-25-0 54671203
3
Azithromycin Approved Phase 4 83905-01-5 55185 447043
4
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
5
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Not Applicable 1406-16-2
6
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 11103-57-4, 68-26-8 445354
7
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 2,Not Applicable 67-97-0 5280795 6221
8 Tocotrienol Investigational Phase 4 6829-55-6
9 Omega 3 Fatty Acid Phase 4
10 Calciferol Phase 4,Phase 2,Not Applicable
11 Micronutrients Phase 4,Phase 1,Not Applicable
12 Tocopherols Phase 4
13 Tocotrienols Phase 4
14 Antioxidants Phase 4
15 Retinol palmitate Phase 4,Not Applicable
16 retinol Phase 4,Not Applicable
17 Vitamins Phase 4,Phase 2,Not Applicable
18 Trace Elements Phase 4,Phase 1,Not Applicable
19 Bone Density Conservation Agents Phase 4,Not Applicable
20 Protective Agents Phase 4,Phase 1,Not Applicable
21 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Antimalarials Phase 4,Phase 3,Phase 2,Not Applicable
23 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
24 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable
25 Immunologic Factors Phase 4,Not Applicable
26 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2,Not Applicable
27 Antitubercular Agents Phase 4,Phase 1,Phase 2,Not Applicable
28 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Vaccines Phase 4
30
Telithromycin Approved Phase 3 191114-48-4 0 5462516
31
Regadenoson Approved, Investigational Phase 3 313348-27-5 219024
32
Adenosine Approved, Investigational Phase 3 58-61-7 60961
33
Donepezil Approved Phase 3 120014-06-4 3152
34 Orange Approved Phase 3
35
chloroquine Approved, Investigational, Vet_approved Phase 3,Phase 2 54-05-7 2719
36 Tafenoquine Approved, Investigational Phase 3,Phase 2 106635-80-7
37
Primaquine Approved Phase 3,Phase 2 90-34-6 4908
38 Neurotransmitter Agents Phase 3,Not Applicable
39 Analgesics, Non-Narcotic Phase 3,Phase 2,Phase 1
40 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 2,Phase 1
41 Analgesics Phase 3,Phase 2,Phase 1,Not Applicable
42 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
43 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1,Not Applicable
44 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1,Not Applicable
45 Nootropic Agents Phase 3
46 Cholinergic Agents Phase 3
47 Cholinesterase Inhibitors Phase 3
48 Anthelmintics Phase 3,Phase 2
49 Chloroquine diphosphate Phase 3,Phase 2 50-63-5
50
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314

Interventional clinical trials:

(show top 50) (show all 97)
# Name Status NCT ID Phase Drugs
1 Effects of Family Work Shop for Children With Developmental Delays Unknown status NCT02523963 Phase 4
2 Oral Nutrition Impact on Tear Film Unknown status NCT01561040 Phase 4
3 The Role of Rapid Diagnostic Tests for Malaria for Targeting of ACTs at Community Level Completed NCT01907672 Phase 4
4 Immunogenicity, Safety and Tolerability of a Trivalent Subunit Inactivated Vaccine in Healthy Subjects 50 Years and Above Completed NCT01867021 Phase 4
5 Scrub Typhus Antibiotic Resistance Trial Recruiting NCT03083197 Phase 4 Doxycycline 7 days;Doxycycline 3 days;Azithromycin 3 days
6 Controlled Trial: 5-Day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Unknown status NCT00351182 Phase 3 Telithromycin;Doxycycline
7 Myocardial Perfusion Assessment With Multidetector Computed Tomography Unknown status NCT00846079 Phase 3
8 Efficacy and Safety Study of Shenwu Capsule Completed NCT01451749 Phase 3 Shenwu Capsule;Donepezil
9 Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax Malaria Completed NCT02216123 Phase 3 Tafenoquine;Tafenoquine Placebo;Chloroquine;Primaquine;Primaquine Placebo
10 Sequential HIPEC of Oxaliplatin and Paclitaxel for Gastric Cancer Patients With Peritoneum Metastasis Unknown status NCT01471132 Phase 2 Oxaliplatin;Paclitaxel
11 A Clinical Trial to Evaluate the Safety and Efficacy of Ciprofloxacin in the Treatment of Plague in Humans Unknown status NCT01243437 Phase 2 ciprofloxacin;doxyxcycline
12 Exercise and NutraStem (NT-020): Effects on Stem Cells Completed NCT01847027 Phase 2 NutraStem;Placebo
13 An Intervention to Reduce Inappropriate Prescriptions of Antibiotics for Respiratory Infections in General Practice Completed NCT00272155 Phase 1, Phase 2
14 Ph 2B/3 Tafenoquine (TFQ) Study in Prevention of Vivax Relapse Completed NCT01376167 Phase 2 Chloroquine 600mg;Chloroquine 300mg;Tafenoquine 50mg;Tafenoquine 100mg;Tafenoquine 300mg;Tafenoquine 600mg;Primaquine 15mg;Chloroquine 600mg (Part 2 );Chloroquine 300mg (Part 2 );Tafenoquine 300mg (Part 2);Primaquine 15mg (Part2 )
15 The Nutritional Supplement Phosphatidylserine in Patients With Familial Dysautonomia Recruiting NCT02276716 Phase 2 Phosphatidylserine
16 If Channel Blockade With Ivabradine in Patients With Diastolic Heart Failure Withdrawn NCT00757055 Phase 2 Ivabradine;Placebo
17 Effect of Zinc Carnosine on Intestinal Permeability in Healthy Volunteers Unknown status NCT00149149 Phase 1 Zinc carnosine
18 NaF/FDG PET/MRI in Measuring Response to Radium Ra 223 Dichloride in Patients With Metastatic Hormone-Resistant Prostate Cancer Terminated NCT02429804 Phase 1 Fludeoxyglucose F-18;Fluorine F 18 Sodium Fluoride
19 Effects of Work Shop for Children With Developmental Delays Unknown status NCT02181036 Not Applicable
20 Controlled Trial: 5-Day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Unknown status NCT00568711 Not Applicable doxycycline;rifampin
21 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
22 A Study to Evaluate the Impact of Direct and Surrogate Advertising and Compliance With the Bill With the Respect to Sale of Tobacco Products Around Educational Institutes Unknown status NCT01275950 Not Applicable
23 Assessing the Effect of Strengthening Referral of Sick Children From the Private Health Sector and Its Impact on Referral Uptake in Uganda. Unknown status NCT02450630 Not Applicable
24 Stress Adenosine Cardiac Magnetic Resonance (MR) Comparison With Single Photon Emission Computed Tomography (SPECT) Imaging Unknown status NCT00864591
25 Comparing Nutritional Status of In-centre Nocturnal Hemodialysis Patients to Conventional Hemodialysis Patients Unknown status NCT02887391
26 IMPACT2: Monitoring Interventions to Improve Artemisinin-based Combination Therapy (ACT) Access and Targeting Unknown status NCT01130155
27 MOMS Hubs- CT Dept of Social Services Block Grant Unknown status NCT02459925 Not Applicable
28 Combination Chemotherapy Followed By Stem Cell Transplant in Treating Young Patients With Progressive or Relapsed Anaplastic Large Cell Lymphoma Unknown status NCT00317408 Not Applicable busulfan;carboplatin;carmustine;cyclosporine;cytarabine;dexamethasone;etoposide phosphate;idarubicin;ifosfamide;leucovorin calcium;lomustine;melphalan;methotrexate;mitoxantrone hydrochloride;prednisolone;thiotepa;vinblastine sulfate;vindesine
29 Impact of Hospital Admission on Patients With Dementia Unknown status NCT02483065
30 Scrub Typhus Pediatric Immunology Study Completed NCT02398162
31 One-stop-shop Study for Treatment of Basal Cell Carcinoma Using Reflectance Confocal Microscopy Completed NCT02285790 Not Applicable
32 Causes of Fever in Bangladeshi Patients Completed NCT02339259
33 Dietary Intervention With Shop Model - SHOPUS Completed NCT01195610 Not Applicable
34 Introducing Rapid Diagnostic Tests Into the Private Health Sector Completed NCT01194557 Not Applicable Lumartem
35 Feasibility and Impact of Malaria Rapid Diagnostic Tests in the African Retail Sector Completed NCT01652365 Not Applicable
36 Adiposity and Airway Inflammation in HIV-Associated Airway Disease Completed NCT02975258
37 Isocyanate Dermal Exposures in Autobody Shops Completed NCT00005552
38 An Interventional Study to Reduce Social Disparities in Diet Quality in the Northern Districts of Marseille Completed NCT02383875 Not Applicable
39 FITShop: Promoting Physical Activity in Black Barbershops Completed NCT01699321 Not Applicable
40 Preoperative Staging of Endometriosis With MRI Completed NCT01939535
41 The Impact of Palm Date Intake on Colon Health Biomarkers Completed NCT02288611 Not Applicable
42 Influence of Light Exposure on Cerebral MAO-A in Seasonal Affective Disorder and Healthy Controls Measured by PET Completed NCT02582398 Not Applicable
43 Role and Effectiveness of Rapid Diagnostic Tests in Home-based Management of Malaria Completed NCT01048801 Not Applicable
44 Examination of Virtual Supermarket (Vmall) as an Assessment of Executive Functions in Children and Adolescents With Acquired Brain Injury Completed NCT00425958
45 The Change Cycle Intervention for Improving Quality of Life in Breast Cancer Survivors Completed NCT01734499 Not Applicable
46 Brazilian Heart-Prevent Meal - A Pilot Randomized Clinical Trial Completed NCT01453166 Not Applicable
47 Virtual Action Planning in Stroke: a Control Rehabilitation Study Completed NCT01365858 Not Applicable
48 San Francisco Health Plan Care Support Trial Completed NCT02463838 Not Applicable
49 The Value of Our Health Completed NCT01475526 Not Applicable
50 Buy 1 Get 1: Role of Grocery Coupons in Promoting Obesogenic Home Food Environments and Eating Behaviors Completed NCT01710124 Not Applicable

Search NIH Clinical Center for Endemic Typhus

Genetic Tests for Endemic Typhus

Anatomical Context for Endemic Typhus

MalaCards organs/tissues related to Endemic Typhus:

41
Testes, Lung, Kidney, Liver, Retina

Publications for Endemic Typhus

Articles related to Endemic Typhus:

(show top 50) (show all 271)
# Title Authors Year
1
Murine Typhus Mimicking Kawasaki Disease in a Preadolescent Girl. ( 29742650 )
2018
2
Laboratory-acquired scrub typhus and murine typhus infections: The argument for risk-based approach to biosafety requirements for Orientia tsutsugamushi and Rickettsia typhi laboratory activities. ( 30107504 )
2018
3
Murine Typhus with Marked Thrombocytopenia in a Child in Northern Greece and Literature Review. ( 29848847 )
2018
4
A Severe Case of Murine Typhus Presenting With Anemia and Severe Thrombocytopenia. ( 29200167 )
2018
5
Murine Typhus in South Texas Children: An 18-year Review. ( 29465481 )
2018
6
Analysis of Health-Care Charges in Murine Typhus: Need for Improved Clinical Recognition and Diagnostics for Acute Disease. ( 29637877 )
2018
7
Murine Typhus and Hemophagocytic Syndrome. ( 29683952 )
2018
8
An Unusual Presentation of Murine Typhus and Mononucleosis. ( 29788215 )
2018
9
A prospective, open-label, randomized trial of doxycycline versus azithromycin for the treatment of uncomplicated murine typhus. ( 30020447 )
2018
10
Comparative Study on the Epidemiological Trends and Aspects of Murine Typhus in Korea in the Last Decade (2006-2015). ( 30166809 )
2018
11
Murine typhus associated abducens nerve palsy. ( 30173785 )
2018
12
Significance of major international seaports in the distribution of murine typhus in Taiwan. ( 28264003 )
2017
13
Correction: Significance of major international seaports in the distribution of murine typhus in Taiwan. ( 28467406 )
2017
14
Severe interstitial pneumonia due to murine typhus in a patient returning from Bali. ( 28560173 )
2017
15
Acute Febrile Illness and Complications Due to Murine Typhus, Texas, USA1,2. ( 28726607 )
2017
16
Opossums and Cat Fleas: New Insights in the Ecology of Murine Typhus in Galveston, Texas. ( 27273642 )
2016
17
Structural features of the O-antigen of Rickettsia typhi, the etiological agent of endemic typhus. ( 26435145 )
2015
18
Murine typhus in a liver transplant recipient: report of a first case. ( 25867285 )
2015
19
Round Pneumonia With Murine Typhus After Travel to Indonesia. ( 26171885 )
2015
20
Misdiagnosed murine typhus in a patient with multiple cerebral infarctions and hemorrhage: a case report. ( 26223226 )
2015
21
Case report: probable murine typhus at Joint Base San Antonio, TX. ( 26295976 )
2015
22
Bilateral optic atrophy in endemic typhus. ( 25103667 )
2014
23
Myositis in a child with murine typhus. ( 24757508 )
2014
24
Pregnancy outcome in relation to treatment of murine typhus and scrub typhus infection: a fever cohort and a case series analysis. ( 25412503 )
2014
25
Murine typhus associated with Parinaud's oculoglandular syndrome in 2 children. ( 24853542 )
2014
26
Severe murine typhus with pulmonary system involvement. ( 25062435 )
2014
27
Murine typhus in elderly patients: a prospective study of 49 patients. ( 25119441 )
2014
28
Murine Typhus: Clinical and epidemiological aspects. ( 24893060 )
2012
29
A cluster of pediatric endemic typhus cases in Orange County, California. ( 21298850 )
2011
30
Postinfectious optic neuropathy in endemic typhus. ( 21897295 )
2011
31
Detection of arbitrarily-shaped clusters using a neighbor-expanding approach: a case study on murine typhus in south Texas. ( 21453514 )
2011
32
Endemic typhus (murine typhus) in an 18 year old Libyan adult. ( 19842415 )
2009
33
Murine typhus in child, Yucatan, Mexico. ( 19523307 )
2009
34
Murine typhus, Algeria. ( 18394297 )
2008
35
Structural features of lipopolysaccharide from Rickettsia typhi: the causative agent of endemic typhus. ( 16481524 )
2005
36
Acute pharyngitis: an unusual presentation of acute endemic typhus. ( 16213963 )
2005
37
Murine (endemic) typhus in Brazil: case report and review. ( 15517036 )
2004
38
Endemic typhus in Singapore--a re-emerging infectious disease? ( 11989574 )
2001
39
The increasing prevalence of Endemic Typhus in Kuala Lumpur and an evaluation of a diagnostic ELISA dot test for the detection of antibodies to Rickettsia typhi. ( 11063173 )
2000
40
Murine typhus in Mexico City. ( 10748896 )
2000
41
Murine typhus in South Texas children. ( 10877169 )
2000
42
Murine typhus in metropolitan Perth. ( 10026693 )
1999
43
Murine typhus as a common cause of fever of intermediate duration: a 17-year study in the south of Spain. ( 10219934 )
1999
44
Scrub and murine typhus among Dutch travellers. ( 10885849 )
1999
45
Imported rickettsioses: think of murine typhus. ( 9566648 )
1998
46
Septic shock and multiorganic failure in murine typhus. ( 9629982 )
1998
47
Murine typhus, Portugal. ( 9763932 )
1998
48
Murine typhus presenting as subacute meningoencephalitis. ( 9776466 )
1998
49
Murine typhus in travelers returning from Indonesia. ( 9866749 )
1998
50
Use of enzyme-linked immunosorbent assay techniques with cross-reacting human sera in diagnosis of murine typhus and spotted fever. ( 9157128 )
1997

Variations for Endemic Typhus

Expression for Endemic Typhus

Search GEO for disease gene expression data for Endemic Typhus.

Pathways for Endemic Typhus

GO Terms for Endemic Typhus

Biological processes related to Endemic Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 8.62 MAPKAPK3 SPTB

Sources for Endemic Typhus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....