MCID: END014
MIFTS: 37

Endemic Typhus

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Endemic Typhus

MalaCards integrated aliases for Endemic Typhus:

Name: Endemic Typhus 12 59 15
Murine Typhus 12 59 3
Rickettsia Felis Spotted Fever 12
Endemic Flea-Borne Typhus 73
Cat Flea Rickettsiosis 12
Urban Typhus of Malaya 12
Flea-Borne Typhus 59
Fleaborne Typhus 12
Rat-Flea Typhus 12
Toulon Typhus 12
Urban Typhus 12
Shop Typhus 12

Characteristics:

Orphanet epidemiological data:

59
murine typhus
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050481
Orphanet 59 ORPHA83315
ICD10 via Orphanet 34 A75.2

Summaries for Endemic Typhus

CDC : 3 Typhus fevers are a group of diseases caused by bacteria that are spread to humans by fleas, lice, and chiggers. Typhus fevers include scrub typhus, murine typhus, and epidemic typhus. Chiggers spread scrub typhus, fleas spread murine typhus, and body lice spread epidemic typhus. The most common symptoms are fever, headaches, and sometimes rash.

MalaCards based summary : Endemic Typhus, also known as murine typhus, is related to spotted fever and epidemic typhus, and has symptoms including headache, fever and chills. An important gene associated with Endemic Typhus is AFF2 (AF4/FMR2 Family Member 2). The drugs Doxycycline and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include testes, breast and brain.

Disease Ontology : 12 A typhus that has material basis in Rickettsia typhi or has material basis in Rickettsia felis, which are transmitted by fleas (Xenopsylla cheopis). The infection has symptom headache, has symptom fever, has symptom chills, has symptom myalgia, has symptom nausea, has symptom vomiting, has symptom cough and has symptom rash.

Related Diseases for Endemic Typhus

Diseases related to Endemic Typhus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 spotted fever 29.1 AFF2 PLEKHG4
2 epidemic typhus 11.4
3 rocky mountain spotted fever 10.0
4 3-methylglutaconic aciduria, type iii 9.8
5 q fever 9.8
6 papilledema 9.8
7 optic nerve disease 9.8
8 pharyngitis 9.8
9 pneumonia 9.8
10 neuropathy 9.8
11 flinders island spotted fever 9.7 AFF2 PLEKHG4
12 japanese spotted fever 9.6 AFF2 PLEKHG4

Graphical network of the top 20 diseases related to Endemic Typhus:



Diseases related to Endemic Typhus

Symptoms & Phenotypes for Endemic Typhus

Symptoms:

12
  • headache
  • fever
  • chills
  • myalgia
  • nausea
  • vomiting
  • cough
  • rash

Drugs & Therapeutics for Endemic Typhus

Drugs for Endemic Typhus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 170)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 564-25-0 54671203
2
Azithromycin Approved Phase 4 83905-01-5 55185 447043
3
Tocopherol Approved, Investigational, Nutraceutical Phase 4 1406-66-2 14986
4
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 11103-57-4, 68-26-8 445354
5
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Not Applicable 1406-16-2
6
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 2,Not Applicable 67-97-0 6221 5280795
7
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
8 Antioxidants Phase 4
9 Bone Density Conservation Agents Phase 4,Not Applicable
10 Micronutrients Phase 4,Phase 1,Not Applicable
11 Protective Agents Phase 4,Phase 1,Not Applicable
12 Retinol palmitate Phase 4
13 Tocopherols Phase 4
14 Tocotrienols Phase 4
15 Trace Elements Phase 4,Phase 1,Not Applicable
16 Vitamins Phase 4,Phase 2,Not Applicable
17 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Antimalarials Phase 4,Phase 3,Phase 2,Not Applicable
19 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
20 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable
21 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2,Not Applicable
23 Antitubercular Agents Phase 4,Phase 1,Phase 2,Not Applicable
24 Vaccines Phase 4
25 Omega 3 Fatty Acid Nutraceutical Phase 4
26 retinol Nutraceutical Phase 4
27 Tocotrienol Investigational, Nutraceutical Phase 4 6829-55-6
28
Telithromycin Approved Phase 3 191114-48-4 5462516 0
29
Adenosine Approved, Investigational Phase 3 58-61-7 60961
30
Regadenoson Approved, Investigational Phase 3 313348-27-5 219024
31
Donepezil Approved Phase 3 120014-06-4 3152
32
chloroquine Approved, Investigational, Vet_approved Phase 3,Phase 2 54-05-7 2719
33
Primaquine Approved Phase 3,Phase 2 90-34-6 4908
34 Orange Approved, Nutraceutical Phase 3
35 Tafenoquine Investigational Phase 3,Phase 2 106635-80-7
36 Neurotransmitter Agents Phase 3
37 Analgesics Phase 3,Phase 2,Phase 1,Not Applicable
38 Analgesics, Non-Narcotic Phase 3,Phase 2,Phase 1
39 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1,Not Applicable
40 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 2,Phase 1
41 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
42 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1,Not Applicable
43 Cholinergic Agents Phase 3
44 Cholinesterase Inhibitors Phase 3
45 Nootropic Agents Phase 3
46 Anthelmintics Phase 3,Phase 2
47 Chloroquine diphosphate Phase 3,Phase 2 50-63-5
48
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 43805 6857599
49
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
50
Ciprofloxacin Approved, Investigational Phase 2 85721-33-1 2764

Interventional clinical trials:

(show top 50) (show all 90)
# Name Status NCT ID Phase Drugs
1 Effects of Family Work Shop for Children With Developmental Delays Unknown status NCT02523963 Phase 4
2 Oral Nutrition Impact on Tear Film Unknown status NCT01561040 Phase 4
3 The Role of Rapid Diagnostic Tests for Malaria for Targeting of ACTs at Community Level Completed NCT01907672 Phase 4
4 Immunogenicity, Safety and Tolerability of a Trivalent Subunit Inactivated Vaccine in Healthy Subjects 50 Years and Above Completed NCT01867021 Phase 4
5 Scrub Typhus Antibiotic Resistance Trial Recruiting NCT03083197 Phase 4 Doxycycline 7 days;Doxycycline 3 days;Azithromycin 3 days
6 Controlled Trial: 5-Day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Unknown status NCT00351182 Phase 3 Telithromycin;Doxycycline
7 Myocardial Perfusion Assessment With Multidetector Computed Tomography Unknown status NCT00846079 Phase 3
8 Efficacy and Safety Study of Shenwu Capsule Completed NCT01451749 Phase 3 Shenwu Capsule;Donepezil
9 Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax Malaria Completed NCT02216123 Phase 3 Tafenoquine;Tafenoquine Placebo;Chloroquine;Primaquine;Primaquine Placebo
10 Sequential HIPEC of Oxaliplatin and Paclitaxel for Gastric Cancer Patients With Peritoneum Metastasis Unknown status NCT01471132 Phase 2 Oxaliplatin;Paclitaxel
11 A Clinical Trial to Evaluate the Safety and Efficacy of Ciprofloxacin in the Treatment of Plague in Humans Unknown status NCT01243437 Phase 2 ciprofloxacin;doxyxcycline
12 Exercise and NutraStem (NT-020): Effects on Stem Cells Completed NCT01847027 Phase 2 NutraStem;Placebo
13 An Intervention to Reduce Inappropriate Prescriptions of Antibiotics for Respiratory Infections in General Practice Completed NCT00272155 Phase 1, Phase 2
14 Ph 2B/3 Tafenoquine (TFQ) Study in Prevention of Vivax Relapse Completed NCT01376167 Phase 2 Chloroquine 600mg;Chloroquine 300mg;Tafenoquine 50mg;Tafenoquine 100mg;Tafenoquine 300mg;Tafenoquine 600mg;Primaquine 15mg;Chloroquine 600mg (Part 2 );Chloroquine 300mg (Part 2 );Tafenoquine 300mg (Part 2);Primaquine 15mg (Part2 )
15 The Nutritional Supplement Phosphatidylserine in Patients With Familial Dysautonomia Recruiting NCT02276716 Phase 2 Phosphatidylserine
16 If Channel Blockade With Ivabradine in Patients With Diastolic Heart Failure Withdrawn NCT00757055 Phase 2 Ivabradine;Placebo
17 Effect of Zinc Carnosine on Intestinal Permeability in Healthy Volunteers Unknown status NCT00149149 Phase 1 Zinc carnosine
18 NaF/FDG PET/MRI in Measuring Response to Radium Ra 223 Dichloride in Patients With Metastatic Hormone-Resistant Prostate Cancer Terminated NCT02429804 Phase 1 Fludeoxyglucose F-18;Fluorine F 18 Sodium Fluoride
19 Effects of Work Shop for Children With Developmental Delays Unknown status NCT02181036 Not Applicable
20 Controlled Trial: 5-Day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Unknown status NCT00568711 Not Applicable doxycycline;rifampin
21 Causes of Fever in Bangladeshi Patients Unknown status NCT02339259
22 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
23 A Study to Evaluate the Impact of Direct and Surrogate Advertising and Compliance With the Bill With the Respect to Sale of Tobacco Products Around Educational Institutes Unknown status NCT01275950 Not Applicable
24 Assessing the Effect of Strengthening Referral of Sick Children From the Private Health Sector and Its Impact on Referral Uptake in Uganda. Unknown status NCT02450630 Not Applicable
25 Stress Adenosine Cardiac Magnetic Resonance (MR) Comparison With Single Photon Emission Computed Tomography (SPECT) Imaging Unknown status NCT00864591
26 IMPACT2: Monitoring Interventions to Improve Artemisinin-based Combination Therapy (ACT) Access and Targeting Unknown status NCT01130155
27 Combination Chemotherapy Followed By Stem Cell Transplant in Treating Young Patients With Progressive or Relapsed Anaplastic Large Cell Lymphoma Unknown status NCT00317408 Not Applicable busulfan;carboplatin;carmustine;cyclosporine;cytarabine;dexamethasone;etoposide phosphate;idarubicin;ifosfamide;leucovorin calcium;lomustine;melphalan;methotrexate;mitoxantrone hydrochloride;prednisolone;thiotepa;vinblastine sulfate;vindesine
28 Impact of Hospital Admission on Patients With Dementia Unknown status NCT02483065
29 One-stop-shop Study for Treatment of Basal Cell Carcinoma Using Reflectance Confocal Microscopy Completed NCT02285790 Not Applicable
30 Dietary Intervention With Shop Model - SHOPUS Completed NCT01195610 Not Applicable
31 Introducing Rapid Diagnostic Tests Into the Private Health Sector Completed NCT01194557 Not Applicable Lumartem
32 Feasibility and Impact of Malaria Rapid Diagnostic Tests in the African Retail Sector Completed NCT01652365 Not Applicable
33 Adiposity and Airway Inflammation in HIV-Associated Airway Disease Completed NCT02975258
34 Isocyanate Dermal Exposures in Autobody Shops Completed NCT00005552
35 An Interventional Study to Reduce Social Disparities in Diet Quality in the Northern Districts of Marseille Completed NCT02383875 Not Applicable
36 FITShop: Promoting Physical Activity in Black Barbershops Completed NCT01699321 Not Applicable
37 Preoperative Staging of Endometriosis With MRI Completed NCT01939535
38 The Impact of Palm Date Intake on Colon Health Biomarkers Completed NCT02288611 Not Applicable
39 Influence of Light Exposure on Cerebral MAO-A in Seasonal Affective Disorder and Healthy Controls Measured by PET Completed NCT02582398 Not Applicable
40 Role and Effectiveness of Rapid Diagnostic Tests in Home-based Management of Malaria Completed NCT01048801 Not Applicable
41 Examination of Virtual Supermarket (Vmall) as an Assessment of Executive Functions in Children and Adolescents With Acquired Brain Injury Completed NCT00425958
42 The Change Cycle Intervention for Improving Quality of Life in Breast Cancer Survivors Completed NCT01734499 Not Applicable
43 Brazilian Heart-Prevent Meal - A Pilot Randomized Clinical Trial Completed NCT01453166 Not Applicable
44 Virtual Action Planning in Stroke: a Control Rehabilitation Study Completed NCT01365858 Not Applicable
45 The Value of Our Health Completed NCT01475526 Not Applicable
46 Buy 1 Get 1: Role of Grocery Coupons in Promoting Obesogenic Home Food Environments and Eating Behaviors Completed NCT01710124 Not Applicable
47 A New Approach to Deliver Malaria Preventions to Pregnant Women at a Community Level in Uganda Completed NCT00118027 Not Applicable sulphadoxine-pyrimethamine intermittent preventive treatment
48 Effects of Ozonated Water on Pain, Swelling, Trismus and Quality of Life in Third Molar Surgery Completed NCT03501225 Not Applicable
49 Shopping Smart - Adolescent Intervention to Improve Shopping Practices Where You Live and Learn Completed NCT02793024 Not Applicable
50 Developing a Preschool Obesity Intervention for Families Enrolled in WIC Completed NCT02292602 Not Applicable

Search NIH Clinical Center for Endemic Typhus

Genetic Tests for Endemic Typhus

Anatomical Context for Endemic Typhus

MalaCards organs/tissues related to Endemic Typhus:

41
Testes, Breast, Brain, Heart, Prostate, Colon, Bone

Publications for Endemic Typhus

Articles related to Endemic Typhus:

(show all 45)
# Title Authors Year
1
Structural features of the O-antigen of Rickettsia typhi, the etiological agent of endemic typhus. ( 26435145 )
2015
2
Bilateral optic atrophy in endemic typhus. ( 25103667 )
2014
3
A cluster of pediatric endemic typhus cases in Orange County, California. ( 21298850 )
2011
4
Postinfectious optic neuropathy in endemic typhus. ( 21897295 )
2011
5
Endemic typhus (murine typhus) in an 18 year old Libyan adult. ( 19842415 )
2009
6
Structural features of lipopolysaccharide from Rickettsia typhi: the causative agent of endemic typhus. ( 16481524 )
2005
7
Acute pharyngitis: an unusual presentation of acute endemic typhus. ( 16213963 )
2005
8
Murine (endemic) typhus in Brazil: case report and review. ( 15517036 )
2004
9
Endemic typhus in Singapore--a re-emerging infectious disease? ( 11989574 )
2001
10
The increasing prevalence of Endemic Typhus in Kuala Lumpur and an evaluation of a diagnostic ELISA dot test for the detection of antibodies to Rickettsia typhi. ( 11063173 )
2000
11
A suburban focus of endemic typhus in Los Angeles County: association with seropositive domestic cats and opossums. ( 8447530 )
1993
12
A serological survey of scrub, tick, and endemic typhus in Sabah, East Malaysia. ( 3107139 )
1986
13
Endemic typhus in Texas. ( 6648836 )
1983
14
Endemic typhus presenting in a nonendemic area. ( 7177916 )
1982
15
Papilledema in endemic typhus. ( 910862 )
1977
16
Prevalence of rodent endemic typhus on the Island of Maui. ( 1016338 )
1976
17
The changing ecology of murine (endemic) typhus in Southern California. ( 4986201 )
1970
18
Pneumonia and endemic typhus. ( 13001584 )
1952
19
Murine (endemic) typhus in Oregon. ( 14843583 )
1951
20
Endemic typhus in Mengo District, Uganda. ( 14840372 )
1951
21
Murine (endemic) typhus in New Jersey; report of a case. ( 15428846 )
1950
22
Treatment of a case of endemic typhus with chloromycetin. ( 18138525 )
1949
23
Endemic typhus in Baltimore. ( 18903106 )
1948
24
The occurrence of endemic typhus fever in Kansas City, Missouri. ( 18916281 )
1948
25
Endemic typhus fever. ( 18857128 )
1948
26
Cross-immune reactions between Panamanian strains of Q fever and endemic typhus. ( 18889641 )
1948
27
Rickettsial diseases of childhood; a clinical pathologic study of tick typhus, Rocky Mountain spotted fever and murine typhus, endemic typhus. ( 20297408 )
1947
28
Endemic typhus fever: clinical study of 24 cases; review of literature. ( 20263894 )
1947
29
The prevalence of endemic typhus fever in Florida. ( 21014107 )
1946
30
An unusual case of endemic typhus fever. ( 20286833 )
1946
31
Para-amino-benzoic acid in the treatment of endemic typhus fever. ( 20997522 )
1946
32
The serologic diagnosis of endemic typhus; the incidence and titer of complement-fixing antibodies in random samples of the population in endemic and nonendemic typhus areas. ( 21027933 )
1946
33
Endemic typhus fever. ( 20286840 )
1946
34
Serological relationships in the epidemic-endemic typhus group as determined by complement fixation. ( 21065206 )
1946
35
Endemic typhus in Manila, Philippine Islands; report of cases and identification of the murine rickettsial agent in domestic rats by complement fixation. ( 21025260 )
1946
36
Fleas carrying endemic typhus rickettsiae found on nonmurine hosts. ( 21064725 )
1946
37
Endemic Typhus Fever in Southern California. ( 18747002 )
1945
38
Endemic Typhus. ( 20785088 )
1943
39
Endemic Typhus Fever in Jamaica, B. W. I. ( 18015844 )
1943
40
An Outbreak of Endemic Typhus Fever in Nashville, Tennessee-Its Epidemiology and Control. ( 18015484 )
1941
41
Recent Extension of Endemic Typhus Fever in the Southern United States. ( 18015396 )
1941
42
Rocky Mountain Spotted Fever and Endemic Typhus Fever: As Observed in California. ( 18743103 )
1934
43
Laboratory Diagnosis of Endemic Typhus and Rocky Mountain Spotted Fever. ( 18013649 )
1933
44
Pathological Study of a Case of Endemic Typhus in Virginia with Demonstration of Rickettsia. ( 19969961 )
1931
45
ENDEMIC TYPHUS IN ALABAMA. ( 20316298 )
1927

Variations for Endemic Typhus

Expression for Endemic Typhus

Search GEO for disease gene expression data for Endemic Typhus.

Pathways for Endemic Typhus

GO Terms for Endemic Typhus

Sources for Endemic Typhus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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