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MCID: END033
MIFTS: 58

Endocarditis

Categories: Blood diseases, Cardiovascular diseases, Infectious diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Endocarditis

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MalaCards integrated aliases for Endocarditis:

Name: Endocarditis 12 73 54 42 44 15 62 17 70

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Cardiovascular diseases Respiratory diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:10314
ICD9CM 34 421.9
MeSH 44 D004696
SNOMED-CT 67 56819008 91357005
ICD10 32 I33.9
UMLS 70 C0014118 C0375268
Sources

Summaries for Endocarditis

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MedlinePlus : 42 Endocarditis, also called infective endocarditis (IE), is an inflammation of the inner lining of the heart. The most common type, bacterial endocarditis, occurs when germs enter your heart. These germs come through your bloodstream from another part of your body, often your mouth. Bacterial endocarditis can damage your heart valves. If untreated, it can be life-threatening. It is rare in healthy hearts. Risk factors include having An abnormal or damaged heart valve An artificial heart valve Congenital heart defects The signs and symptoms of IE can vary from person to person. They also can vary over time in the same person. Symptoms you might notice include fever, shortness of breath, fluid buildup in your arms or legs, tiny red spots on your skin, and weight loss. Your doctor will diagnose IE based on your risk factors, medical history, signs and symptoms, and lab and heart tests. Early treatment can help you avoid complications. Treatment usually involves high-dose antibiotics. If your heart valve is damaged, you may need surgery. If you're at risk for IE, brush and floss your teeth regularly, and have regular dental checkups. Germs from a gum infection can enter your bloodstream. If you are at high risk, your doctor might prescribe antibiotics before dental work and certain types of surgery. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Endocarditis is related to nonbacterial thrombotic endocarditis and infective endocarditis, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Endocarditis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs Rifampicin and Imipenem have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and kidney, and related phenotypes are Reduced mammosphere formation and cardiovascular system

Disease Ontology : 12 A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves.

PubMed Health : 62 About endocarditis: Endocarditis (EN-do-kar-DI-tis) is an infection of the inner lining of the heart chambers and valves. This lining is called the endocardium (en-do-KAR-de-um). The condition also is called infective endocarditis (IE). The term "endocarditis" also is used to describe an inflammation of the endocardium due to other conditions. This article only discusses endocarditis related to infection. IE occurs if bacteria, fungi, or other germs invade your bloodstream and attach to abnormal areas of your heart. The infection can damage your heart and cause serious and sometimes fatal complications. IE can develop quickly or slowly; it depends on what type of germ is causing it and whether you have an underlying heart problem. When IE develops quickly, it's called acute infective endocarditis. When it develops slowly, it's called subacute infective endocarditis.

Wikipedia : 73 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

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Related Diseases for Endocarditis

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Diseases in the Endocarditis family:

Subacute Bacterial Endocarditis

Diseases related to Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1515)
# Related Disease Score Top Affiliating Genes
1 nonbacterial thrombotic endocarditis 32.9 SERPINC1 PF4 IL6 F2 CRP APOH
2 infective endocarditis 32.6 TNNI3 TNF TLR2 PF4 LBP IL6
3 aortic valve insufficiency 31.9 TNNI3 F2 CRP ALB
4 mitral valve insufficiency 31.8 TNNI3 PIK3C2A F2 CRP ALB
5 brucellosis 31.7 TNF IL6 IL17A IL10 IFNG CXCL8
6 rheumatic heart disease 31.7 TNF TLR2 IL6 IL10
7 q fever 31.6 TNF TLR2 IL6 IL10 IFNG
8 congestive heart failure 31.6 TNNI3 TNF PIK3C2A IL6 CRP ALB
9 heart valve disease 31.5 TNNI3 F2 CRP APOH ALB
10 tricuspid valve insufficiency 31.5 TNNI3 F2 CRP ALB
11 cardiogenic shock 31.5 TNF IL6
12 intracranial embolism 31.4 SERPINC1 F2 CRP ALB
13 hemopericardium 31.4 TNNI3 F2 CRP
14 acute kidney failure 31.3 PIK3C2A F2 ALB
15 hypereosinophilic syndrome 31.3 IL10 IFNG EPX CXCL8
16 splenic abscess 31.3 LACTB F2 CRP ALB
17 mitral valve disease 31.3 TNNI3 IL10 F2 CRP
18 mitral valve stenosis 31.3 SERPINC1 PF4 F2 CRP
19 rheumatic fever 31.2 TNF TLR2 IL6 IL10 IFNG ALB
20 vasculitis 31.2 TNF IL6 IL17A HSPD1 CRP APOH
21 antiphospholipid syndrome 31.2 TNF SERPINC1 PF4 F2 CRP APOH
22 septic arthritis 31.1 TNF TLR2 IFNG CXCL8 CRP
23 atrial heart septal defect 31.1 TNNI3 SERPINC1 F2 CRP ALB
24 pericarditis 31.1 TNNI3 TNF IL6 IFNG CXCL8 CRP
25 end stage renal disease 31.1 TNF IL6 IL10 CRP ALB
26 splenic infarction 31.1 SERPINC1 F2 CRP APOH ALB
27 osteomyelitis 31.1 TNF TLR2 IL6 IL10 IFNG CXCL8
28 endomyocardial fibrosis 31.1 TNF IL10 EPX
29 haemophilus influenzae 31.1 TNF TLR2 LACTB CXCL8
30 pulmonary embolism 31.1 TNNI3 SERPINC1 GP1BA F2 CRP APOH
31 penicillin allergy 31.1 LACTB IL10 IFNG
32 aortitis 31.1 TNF IL6 IL17A CRP
33 endophthalmitis 31.0 TNF TLR2 IL6 CXCL8 CRP ALB
34 mediastinitis 31.0 LACTB F2 CRP ALB
35 pericardial effusion 31.0 TNNI3 PIK3C2A IL6 F2 CRP ALB
36 epidural abscess 31.0 F2 CRP ALB
37 disseminated intravascular coagulation 30.9 TNF SERPINC1 PIK3C2A IL6 IL10 F2
38 tricuspid valve disease 30.9 TNNI3 F2 CRP ALB
39 mycobacterium fortuitum 30.9 LACTB HSPD1 CXCL8
40 myocarditis 30.9 TNNI3 TNF PIK3C2A IL6 IL17A IL10
41 cardiac tamponade 30.9 TNNI3 PIK3C2A F2 CRP ALB
42 toxic shock syndrome 30.9 TNF TLR2 SERPINC1 LBP IL6 IL10
43 pleural empyema 30.9 IL6 F2 CRP ALB
44 limb ischemia 30.9 TNNI3 TNF IL6 F2
45 thrombophlebitis 30.8 SERPINC1 F2 CRP APOH ALB
46 cellulitis 30.8 TNF LACTB IL6 F2 CRP ALB
47 cryoglobulinemia 30.8 TNF IL6 IFNG APOH
48 thrombosis 30.8 SERPINC1 PF4 GP1BA F2 APOH
49 spondylitis 30.8 TNF IL6 IL17A IL10 IFNG CRP
50 acute myocardial infarction 30.7 TNNI3 SERPINC1 PIK3C2A PF4 IL6 CRP

Graphical network of the top 20 diseases related to Endocarditis:



Diseases related to Endocarditis
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Symptoms & Phenotypes for Endocarditis

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UMLS symptoms related to Endocarditis:


angina pectoris; chest pain; edema

GenomeRNAi Phenotypes related to Endocarditis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ALB CXCL8 GP1BA HSPD1 IL17A PIK3C2A

MGI Mouse Phenotypes related to Endocarditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.25 ALB CRP F2 HSPD1 IFNG IL10
2 homeostasis/metabolism MP:0005376 10.25 ALB APOH CRP EPX F2 GP1BA
3 hematopoietic system MP:0005397 10.18 EPX GP1BA HSPD1 IFNG IL10 IL17A
4 immune system MP:0005387 10.07 ALB CRP EPX F2 IFNG IL10
5 digestive/alimentary MP:0005381 10.01 ALB F2 IFNG IL10 IL17A IL6
6 liver/biliary system MP:0005370 9.76 ALB IFNG IL10 IL6 LBP SERPINC1
7 muscle MP:0005369 9.65 ALB F2 HSPD1 IFNG IL10 IL6
8 respiratory system MP:0005388 9.28 F2 HSPD1 IFNG IL10 IL17A IL6
Sources

Drugs & Therapeutics for Endocarditis

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PubMed Health treatment related to Endocarditis: 62

Infective endocarditis (IE) is treated with antibiotics and sometimes with heart surgery .

Drugs for Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 146)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifampicin Approved Phase 4 13292-46-1 5458213 5381226
2
Imipenem Approved Phase 4 64221-86-9, 74431-23-5 104838
3
tannic acid Approved Phase 4 1401-55-4
4
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
5
Oritavancin Approved, Investigational Phase 4 171099-57-3 16129632
6
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
7
Vancomycin Approved Phase 4 1404-90-6 441141 14969
8
Ceftaroline fosamil Approved, Investigational Phase 4 229016-73-3
9
Linezolid Approved, Investigational Phase 4 165800-03-3 441401
10 Amoxicillin-Potassium Clavulanate Combination Phase 4
11 Clavulanic Acids Phase 4
12 Anesthetics Phase 4
13 Analgesics, Opioid Phase 4
14 Antitubercular Agents Phase 4
15 methicillin Phase 4
16 Anti-Bacterial Agents Phase 4
17 Gentamicins Phase 4
18 Anti-Infective Agents Phase 4
19 Antibiotics, Antitubercular Phase 4
20
Ofloxacin Approved Phase 3 82419-36-1 4583
21
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
22
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
23
Ceftriaxone Approved Phase 3 73384-59-5 5479530 5361919
24
Netilmicin Approved, Investigational Phase 3 56391-56-1 441306 6857423
25
Penicillin G Approved, Vet_approved Phase 3 61-33-6 5904
26
Procaine Approved, Investigational, Vet_approved Phase 3 59-46-1 4914
27
Ceftobiprole Approved, Investigational Phase 3 209467-52-7 6918430
28
Aztreonam Approved Phase 3 78110-38-0 5362041 5742832
29
Oxacillin Approved, Investigational Phase 3 66-79-5 6196
30
Cloxacillin Approved, Investigational, Vet_approved Phase 3 61-72-3 6098
31
Cefazolin Approved Phase 3 25953-19-9 656510 33255
32
Telavancin Approved Phase 3 372151-71-8
33
Nafcillin Approved, Investigational Phase 3 147-52-4, 985-16-0 8982
34
Ceftobiprole medocaril Experimental, Investigational Phase 3 376653-43-9
35 Fluoroquinolones Phase 3
36 Cytochrome P-450 Enzyme Inhibitors Phase 3
37 Penicillin G Benzathine Phase 3
38 Penicillin G Procaine Phase 3
39 penicillins Phase 3
40
Dalbavancin Approved, Investigational Phase 2 171500-79-1, 91097-81-3 122186
41 Annexin A5 Phase 1, Phase 2
42
Dexmedetomidine Approved, Vet_approved 113775-47-6 68602 5311068
43
Trovafloxacin Approved, Investigational, Withdrawn 147059-72-1 62959
44
Povidone Approved 9003-39-8 131751496
45
Ciprofloxacin Approved, Investigational 85721-33-1 2764
46
Dopamine Approved 51-61-6, 62-31-7 681
47
Cefepime Approved, Investigational 88040-23-7 5479537
48
Methylprednisolone Approved, Vet_approved 83-43-2 6741
49
Molindone Approved 7416-34-4 23897
50
Haloperidol Approved 52-86-8 3559

Interventional clinical trials:

(show top 50) (show all 108)
# Name Status NCT ID Phase Drugs
1 An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Unknown status NCT02783404 Phase 4 Amoxicillin;Amoxicillin-Potassium Clavulanate
2 Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study: a Multicenter, Prospective, Randomized Trial Comparing the State-of-the-Art Therapeutic Strategy Versus Early Surgery Strategy in Infective Endocarditis Unknown status NCT00624091 Phase 4
3 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Unknown status NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
4 Pharmacokinetics/ Pharmacodynamics (PK/PD) Study of Vancomycin in the Treatment of Methicillin-resistant Staphylococcus Aureus（MRSA） Blood Stream Infection (Septicemia) and Endocarditis in Chinese Patients Unknown status NCT02443064 Phase 4 Vancomycin
5 A Randomized Comparison of Early Surgery Versus Conventional Treatment Strategy in Patients With High Embolic Risk of Infective Endocarditis Completed NCT00750373 Phase 4
6 Evaluation of the Efficacy and Safety of Fosfomycin Plus Imipenem for the Treatment of Methicillin-resistant Staphylococcus Aureus (MRSA) Infective Endocarditis. Completed NCT00871104 Phase 4 Fosfomycin and imipenem;Vancomycin
7 Partial Oral Treatment of Endocarditis Completed NCT01375257 Phase 4 Oral treatment with antibiotics for endocarditis;Guideline treatment with parenteral antibiotics
8 Health Economic Evaluation of Rapid Detection of Bacteraemia and Fungemia by Real Time PCR for Cases of Febrile Neutropenia, Suspicion of Endocarditis and Severe Sepsis in Intensive Care Units Completed NCT00709358 Phase 4
9 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Completed NCT01920126 Phase 4 sodium bicarbonate;Saline
10 Short-course Antibiotic Regimen Compared to Conventional Antibiotic Treatment for Gram-positive Cocci Infective Endocarditis: Randomized Clinical Trial Recruiting NCT04222257 Phase 4 Antibiotics;Antibiotics
11 A Pilot Proof of Concept Single-Center Study of the Use of Oritavancin in Systemic Staphylococcus Aureus Infections in Patients With Opioid Use Disorder Recruiting NCT03761953 Phase 4 Oritavancin Injection
12 A Phase 4 Multicenter, Randomized, Double Blind Study to Describe the Efficacy and Safety of Cubicin® (Daptomycin for Injection) With and Without Initial Gentamicin Combination Therapy in the Treatment of S. Aureus Infective Endocarditis Terminated NCT00638157 Phase 4 daptomycin;daptomycin and gentamicin
13 Open Label Study to Assess the Efficacy and Safety of Daptomycin in Combination With Anti-Cell Wall Active Therapy in the Treatment of Enterococcal Endocarditis Terminated NCT00401960 Phase 4 Daptomycin
14 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
15 A Phase 3, Multicenter, Randomized, Open-Label, Comparative Study to Assess the Safety and Efficacy of Daptomycin Compared to Conventional Therapy In the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to Staph Aureus Completed NCT00093067 Phase 3 daptomycin
16 A Phase III Randomized, Open-labeled Clinical Trial of MK-3009 (Daptomycin) in Patients With Skin and Soft Tissue Infections, Septicemia and Right-sided Infective Endocarditis Caused by MRSA Completed NCT00770341 Phase 3 Daptomycin 4 mg/kg;Comparator: vancomycin;Daptomycin 6 mg/kg
17 Population Pharmacokinetic (PK) Study of Multiple Doses of Cubicin® (Daptomycin) 10 mg/kg in Critical Care Patients Having Bacteremia, Endocarditis or Skin Soft Tissue Infections Due to Gram Positive Bacteria With Various Degrees of Renal Failure Completed NCT02142075 Phase 3 Daptomycin
18 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus (Relais Oral Dans le Traitement Des Endocardites à Streptocoques Multi-sensibles) Recruiting NCT02701595 Phase 3 Amoxicillin
19 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus (Relais Oral Dans le Traitement Des Endocardites à Staphylocoques Multi-sensibles) Recruiting NCT02701608 Phase 3 Levofloxacin;Rifampicin
20 A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of a Single Dose of Exebacase in Patients Receiving Standard-of-Care Antibiotics for the Treatment of Staphylococcus Aureus Bloodstream Infections (Bacteremia), Including Right-Sided Infective Endocarditis Recruiting NCT04160468 Phase 3 Exebacase;Placebo
21 A Randomized, Double-blind, Multi-center Study to Establish the Efficacy and Safety of Ceftobiprole Medocaril Compared to Daptomycin in the Treatment of Staphylococcus Aureus Bacteremia, Including Infective Endocarditis Recruiting NCT03138733 Phase 3 Ceftobiprole medocaril;Daptomycin
22 A Phase 3 Multicenter, Randomized, Open-label, Clinical Trial of Telavancin Versus Standard Intravenous Therapy in the Treatment of Subjects With Staphylococcus Aureus Bacteremia Including Infective Endocarditis Terminated NCT02208063 Phase 3 Telavancin;Vancomycin;Daptomycin;Synthetic penicillin;Cefazolin
23 Phase II Clinical Trial to Evaluate an Antibiotic Regimen Pharmacokinetic Applicable to Outpatient Parenteral Antimicrobial Therapy in Enterococcus Faecalis Infective Endocarditis Unknown status NCT03681431 Phase 2 Ceftriaxone 4g/ 24h;Ceftriaxone 2g/ 12h
24 Evaluation de la rhAnnexine V-128 radiomarquée Dans le Diagnostic de l'Endocardite Infectieuse, du Thrombus Atrial et de Leurs Complications Emboliques associées Unknown status NCT02459613 Phase 1, Phase 2
25 A Multicenter, Double-Blind, Randomized, Comparative Study of the Safety, Tolerability, Efficacy, and Pharmacokinetics of CF-301 vs. Placebo in Addition to Standard-of-Care Antibacterial Therapy for the Treatment of Adult Patients With Staphylococcus Aureus Bloodstream Infections (Bacteremia) Including Endocarditis Completed NCT03163446 Phase 2 Placebo
26 Hyperbaric Oxygen Treatment in Humans With Gram Positive Cocci Endocarditis" Recruiting NCT04691440 Phase 2 Hyperbaric oxygen
27 A Multi-centre Open Label Randomized Controlled Phase IIB Trial Comparing Vancomycin Versus Daptomycin for the Treatment of MRSA Bacteremia Due to Isolates With High Vancomycin Minimum Inhibitory Concentrations Terminated NCT01975662 Phase 2 Daptomycin;Vancomycin
28 A Phase 2 Multicenter, Randomized, Double-blinded, Study to Describe the Safety, Efficacy, and Pharmacokinetics of Daptomycin 10 mg/kg/Day and Vancomycin for the Treatment of Methicillin-resistant Staphylococcus Aureus Bacteremia Terminated NCT00695903 Phase 2 daptomycin;vancomycin
29 Phase 2, Open-Label, Randomized, Multicenter Study to Compare the Efficacy and Safety of Dalbavancin to Standard of Care Antibiotic Therapy for the Completion of Treatment of Patients With Complicated Bacteremia or Documented Infective Endocarditis Terminated NCT03148756 Phase 2 Dalbavancin;Standard of Care
30 Multi-centre, Randomised, Open Label, Phase IIb Study to Compare the Efficacy, Safety and Pharmacokinetics (PK) of an Optimised Dosing to a Standard Dosing Regimen of Vancomycin in Neonates and Infants Aged ≤ 90 Days With Late Onset Bacterial Sepsis Known or Suspected to be Caused by Gram-positive Microorganisms Terminated NCT02790996 Phase 2 Vancomycin
31 Impact of Setting up a Multidisciplinary Consensus Meeting in the Prognosis and Management of Infectious Endocarditis at Strasbourg University Hospital. Unknown status NCT03429153
32 Etiology of Endocarditis in Negative Blood Cultures Unknown status NCT02816307
33 Stroke-free Survival Comparison Between Early Surgery and Conventional Therapy in Left Infective Endocarditis - A Multicenter Partially Randomized Preference Trial (EARLY Study) Unknown status NCT03411499
34 Treatment of Infective Endocarditis by Vancomycin and Gentamycin in Assiut University Children Hospital Unknown status NCT03688659 Vancomycin and gentamycin
35 Study of Autoantibodies in Infective Endocarditis Unknown status NCT00562653
36 Molecular Imaging in Infective Endocarditis Using Hybrid Positron Emission Tomography/Magnetic Resonance Imaging (PET/MR) and Computed Tomography (PET/CT) Unknown status NCT03626571
37 Impact of Clinical Care Pathway on Prognosis and Therapeutic Medical Care of Infective Endocarditis Unknown status NCT02856607
38 The Use of Cardiac Computarized Tomography in Infective Endocarditis Unknown status NCT00550823
39 Effect of Dexmedetomidine on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Unknown status NCT02698930 dexmedetomidine;Normal saline
40 Detection of the Most Common Micro Organism of Infective Endocarditis in Assiut University Hospital Unknown status NCT03487653
41 Long-term Clinico-radiological Evolution of Patients With Symptomatic and Asymptomatic Brain Lesions During Infectious Endocarditis Unknown status NCT02252900
42 Research Interest Antiphospholipid in Predicting Embolic Risk During Infective Endocarditis Unknown status NCT02887079
43 Beta-lactam Pharmacokinetic Profiles in Patients With Infective Endocarditis Unknown status NCT02033421
44 Positron Emission Tomography Combined With Computed Tomography (PET CT) in Suspected Cardiovascular Implantable Electronic Device Infection, a Pilot Study - PET Guidance I Unknown status NCT02196753
45 Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study Unknown status NCT02128139
46 Clinical Metagenomics of Infective Endocarditis Unknown status NCT03199287
47 Development of the Purification of Human Cardiac Mitochondria, Characterization of These Organelles and Validation of the Model in Acute Endocarditis and Obesity Unknown status NCT03690076
48 Diagnostic Value of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Prosthetic Valve Endocarditis Unknown status NCT01916005
49 Retrospective Evaluation of Safety and Efficacy of Daptomycin Used in Patients With Serious Gram-positive Infections Unknown status NCT01301638
50 Assessment of Diagnostic Accuracy of 18FDG-PET-CT in Patients With Suspicion of Pacing or Defibrillation Lead Infection: a Prospective Multi-center Study Unknown status NCT02251262

Search NIH Clinical Center for Endocarditis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


GENTAMICIN SULFATE PWDR

Cochrane evidence based reviews: endocarditis

Sources

Genetic Tests for Endocarditis

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Sources

Anatomical Context for Endocarditis

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MalaCards organs/tissues related to Endocarditis:

40
Heart, Liver, Kidney, Brain, Skin, Bone, Colon
Sources

Publications for Endocarditis

About this section

Articles related to Endocarditis:

(show top 50) (show all 30002)
# Title Authors PMID Year
1
Dental Medicine and Infective Endocarditis: Current guidelines for antibiotic prophylaxis and recommendations for daily clinical practice. 42 61
33666387 2021
2
Synthesis of silver nanoparticles using gum Arabic: Evaluation of its inhibitory action on Streptococcus mutans causing dental caries and endocarditis. 42 61
33618277 2021
3
Patients with infective endocarditis and history of injection drug use in a Swedish referral hospital during 10 years. 61 42
33653292 2021
4
Fibronectin-binding proteins and clumping factor A in Staphylococcus aureus experimental endocarditis: FnBPA is sufficient to activate human endothelial cells. 54 61
17393025 2007
5
Safety evaluation of Lactobacillus delbrueckii subsp. lactis UO 004, a probiotic bacterium. 54 61
15748979 2005
6
Bartonella koehlerae, a new cat-associated agent of culture-negative human endocarditis. 54 61
15297484 2004
7
Haemophilus parainfluenzae endocarditis in a patient with mitral valve prolapse. 54 61
8323254 1993
8
Activity of ampicillin plus sulbactam against beta-lactamase producing enterococci in experimental endocarditis. 61 54
8444668 1993
9
Killing curve activity of ciprofloxacin is comparable to synergistic effect of beta-lactam-tobramycin combinations against Haemophilus species endocarditis strains. 61 54
1389104 1992
10
Thiocyanate is the major substrate for eosinophil peroxidase in physiologic fluids. Implications for cytotoxicity. 54 61
2002037 1991
11
Bromide-dependent toxicity of eosinophil peroxidase for endothelium and isolated working rat hearts: a model for eosinophilic endocarditis. 61 54
1985118 1991
12
Efficacy of amoxycillin/clavulanic acid in experimental Staphylococcus aureus endocarditis in the rat. 61 54
2050588 1991
13
Methicillin-resistant Staphylococcus pseudintermedius synthesizes deoxyadenosine to cause persistent infection. 61
33779509 2021
14
Sterile subconjunctival abscess in an HLA-B51-positive patient with ulcerative colitis. 61
33659764 2021
15
Simultaneous bilateral choroidal neovascularization associated with Staphylococcus aureus infective endocarditis: A case report. 61
33681530 2021
16
First case report of prosthetic valve endocarditis caused by Mycobacterium wolinskyi. 61
33402304 2021
17
Loeffler's Endocarditis and Hypereosinophilic Syndrome. 61
32520731 2021
18
Severe Tricuspid Regurgitation in an Elderly Man With a Pacemaker Generator Eroding Through the Skin: Endocarditis, Perforation, Lead-Induced Impingement, or Another Mechanism? 61
33158708 2021
19
Clinical characteristics and outcomes in patients with echocardiographic left ventricular spontaneous echo contrast. 61
33577908 2021
20
Infective endocarditis in patients with aortic grafts. 61
33592240 2021
21
Long-term follow-up of patients with infective endocarditis in a tertiary referral center. 61
33545260 2021
22
Late Surgical Treatment for Transcatheter Aortic Valve Prosthesis Dysfunction. 61
32979373 2021
23
Minimally-invasive mitral valve repair of symmetric and asymmetric Barlow´s disease. 61
33792775 2021
24
Mitral Valve Surgery After Failed MitraClip: A Single-Center Experience. 61
33794477 2021
25
Dental caries prevalence in children with congenital heart disease - a systematic review. 61
33415995 2021
26
Sutureless aortic valves in elderly patients with aortic stenosis and intermediate-risk profile. 61
33633045 2021
27
Perceval Sutureless Aortic Valve Implantation: Midterm Outcomes. 61
32866479 2021
28
Commentary: Endocarditis of the forgotten valve: Forget about valvectomy? 61
32007250 2021
29
Dialysis and Endocarditis: Proving What We Know, Learning What We Didn't. 61
33795038 2021
30
Multimodality Imaging-Guided Evaluation and Management of Prosthetic Aortic Valve Endocarditis Complicated by a Giant Peri-Aortic Abscess. 61
33794651 2021
31
Microbubbles Mimicking Prosthetic Mitral Valve Thrombosis. 61
33794483 2021
32
Morbidity and Mortality of Spinal Epidural Abscess in End-Stage Renal Disease Patients: A Case-Control Study. 61
33637307 2021
33
Multimodality Evaluation of a Septal Cystic Cavity and Ventricular Septal Defect in the Setting of Neurocysticercosis and Endocarditis. 61
33794648 2021
34
Role or oritavancin and dalbavancin in acute bacterial skin and skin structure infections and other potential indications. 61
33405480 2021
35
Medications for Opioid use Disorder Associated With Less Against Medical Advice Discharge Among Persons Who Inject Drugs Hospitalized With an Invasive Infection. 61
32804690 2021
36
Ceftaroline fosamil: clinical experience after 23-month prescription in a tertiary hospital. 61
33586407 2021
37
Endomyocardiofibrosis: A Systematic Review. 61
33418479 2021
38
Distant metastatic foci of infection in adult patients with diabetic foot - not as rare as we think?: case series and review of the literature. 61
33423592 2021
39
F-18 fluorodeoxyglucose positron emission tomography/computed tomography in the infection of heart. 61
33053614 2021
40
Klebsiella oxytoca and Emerging Nosocomial Infections. 61
33656584 2021
41
Is 67gallium dead? A retrospective review of 67gallium imaging in a single tertiary referral centre. 61
33323867 2021
42
Endocarditis due to Trichosporon beigelii 11 years after mitral valve replacement. 61
33752978 2021
43
A prospective comparison of four methods for preventing pacemaker pocket infections. 61
33001439 2021
44
[Evolution of antimicrobial resistance and mortality in Staphylococcus aureus endocarditis during 15 years in a university hospital]. 61
33491408 2021
45
Opioid abuse surveillance in patients with endocarditis. 61
32814665 2021
46
Endocarditis at a large community hospital with on-site cardiac surgery. 61
33665354 2021
47
Infective endocarditis in patients with heart transplantation. 61
33309761 2021
48
Usefulness of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Diagnosis of Infective Endocarditis in Patients With Adult Congenital Heart Disease. 61
33790144 2021
49
Analysis of the frequency of bacteraemia of dental origin implicated in infective endocarditis in patients requiring valve surgery. 61
33293181 2021
50
Huge Mycotic Aneurysm at the Celiac Trunk in a Patient With Severe Aortic Regurgitation Due to Infective Endocarditis. 61
33790145 2021
Sources

Variations for Endocarditis

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Expression for Endocarditis

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Search GEO for disease gene expression data for Endocarditis.
Sources

Pathways for Endocarditis

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Pathways related to Endocarditis according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 65
Show member pathways
 13.37 TNF LBP IL6 IL17A IL10 IFNG
2
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.22 TNF TLR2 LBP IL6 IL10 IFNG
3
Allograft rejection 36 1
Show member pathways
 12.8 TNF IL6 IL17A IL10 IFNG HSPD1
4
Salmonella infection (KEGG) 36
Show member pathways
 12.78 TNF TLR2 PIK3C2A IL6 F2 CXCL8
5
T cell receptor signaling pathway 36
Show member pathways
 12.63 TNF TLR2 IL6 IL17A IL10 IFNG
6
Th17 cell differentiation 36
Show member pathways
 12.62 TNF TLR2 IL6 IL17A IL10 IFNG
7
Immune response IL-23 signaling pathway 23
Show member pathways
 12.6 TNF IL6 IL17A IL10 IFNG F2
8
NF-kappaB Signaling 4
12.59 TNF TLR2 IL17A IL10 IFNG
9
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.37 TNF PF4 IL6 IL10 CXCL8
10
Toll Comparative Pathway 63
Show member pathways
 12.36 TNF LBP IL6 IFNG CXCL8
11
Selenium Micronutrient Network 1
Show member pathways
 12.35 TNF IL6 IFNG F2 CRP ALB
12
IL-17 Family Signaling Pathways 64
Show member pathways
 12.34 TNF TLR2 IL6 IL17A IFNG CXCL8
13
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.29 TNF TLR2 IL6 CXCL8
14
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.29 TNF IL6 IL17A IL10 IFNG CXCL8
15
Toxoplasmosis 36
Show member pathways
 12.28 TNF TLR2 IL10 IFNG
16
IL-1 Family Signaling Pathways 64
Show member pathways
 12.25 TNF TLR2 IL6 CXCL8
17
Colorectal Cancer Metastasis 63
12.21 TNF TLR2 IL6 IFNG
18
Formation of Fibrin Clot (Clotting Cascade) 65
Show member pathways
 12.19 SERPINC1 PF4 GP1BA F2
19
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.18 TNF IL6 IL10 HSPD1 CXCL8
20
Bacterial infections in CF airways 23
Show member pathways
 12.17 TNF TLR2 LBP IL6 IFNG CXCL8
21
Yersinia infection 36
12.12 TNF IL6 IL10 CXCL8
22
Spinal Cord Injury 1
12.05 TNF IL6 IFNG CXCL8
23
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
12.02 TNF IL6 IL10 IFNG GP1BA
24
Tuberculosis 36
11.96 TNF TLR2 LBP IL6 IL10 IFNG
25
Cytokine production by Th17 cells in CF (Mouse model) 23
Show member pathways
 11.92 LBP IL6 IL17A CXCL8
26
Th17 Differentiation Pathway 64
Show member pathways
 11.91 TLR2 IL6 IL17A IFNG
27
Interleukin-4 and 13 signaling 65
11.9 TNF LBP IL6 IL17A IL10 CXCL8
28
Innate Lymphoid Cell Differentiation Pathways 64
11.84 TNF IL17A IL10 IFNG
29
Pertussis 36
11.81 TNF IL6 IL10 CXCL8
30
Amoebiasis 36
11.81 TNF TLR2 IL6 IL10 IFNG CXCL8
31
Dendritic Cells Developmental Lineage Pathway 64
11.79 TNF IL6 IL10 IFNG
32
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.77 TNF IFNG CXCL8
33
IgA-Producing B Cells in the Intestine 64
11.74 TNF TLR2 IL6 IL10
34
Rheumatoid arthritis 36
11.7 TNF TLR2 IL6 IL17A IFNG CXCL8
35
Lung fibrosis 1
11.68 TNF IL6 CXCL8
36
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.68 TNF IL6 IFNG CXCL8
37
ATF-2 transcription factor network 1
11.62 IL6 IFNG CXCL8
38
Photodynamic therapy-induced AP-1 survival signaling. 1
11.58 TNF IL6 IFNG
39
Interleukin-10 signaling 65
11.56 TNF IL6 IL10 CXCL8
40
Legionellosis 36
11.56 TNF TLR2 IL6 HSPD1 CXCL8
41
MSP-RON Signaling 63
11.55 TNF TLR2 IFNG
42
amb2 Integrin signaling 1
11.55 TNF IL6 GP1BA
43
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.51 TNF IL6 IFNG
44
African trypanosomiasis 36
11.42 TNF IL6 IL10 IFNG
45
IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.41 TNF IL10 IFNG
46
IL-10 Pathway 63
11.39 TNF IL6 IL10
47
Development and heterogeneity of the ILC family 1
11.32 TNF IL6 IL17A IFNG
48
Th1 Differentiation Pathway 64
Show member pathways
 11.31 TNF TLR2 IL6 IL17A IL10 IFNG
49
Cytokines and Inflammatory Response 1
11.26 TNF IL6 IL10 IFNG
50
IL1 and megakaryocytes in obesity 1
11.23 TLR2 IFNG F2
Sources

GO Terms for Endocarditis

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Cellular components related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 SERPINC1 PIK3C2A LBP HSPD1 GP1BA F2
2 extracellular region GO:0005576 9.8 TNF SERPINC1 PF4 LBP IL6 IL17A
3 cell surface GO:0009986 9.63 TNF TLR2 LBP HSPD1 GP1BA APOH
4 extracellular space GO:0005615 9.53 TNF SERPINC1 PF4 LBP IL6 IL17A

Biological processes related to Endocarditis according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.08 TNF TLR2 PF4 IL6 IFNG CXCL8
2 immune response GO:0006955 10.01 TNF TLR2 PF4 IL6 IL17A IL10
3 cellular protein metabolic process GO:0044267 10 SERPINC1 IL6 F2 ALB
4 inflammatory response GO:0006954 10 TNF TLR2 PF4 IL6 IL17A CXCL8
5 response to lipopolysaccharide GO:0032496 9.96 TLR2 LBP IL10 HSPD1
6 defense response GO:0006952 9.95 TNF PF4 EPX CXCL8
7 platelet activation GO:0030168 9.93 PF4 IL6 GP1BA F2
8 positive regulation of inflammatory response GO:0050729 9.91 TNF TLR2 IFNG HSPD1
9 cellular response to lipopolysaccharide GO:0071222 9.91 TNF PF4 LBP IL6 IL10 CXCL8
10 cytokine-mediated signaling pathway GO:0019221 9.91 TNF PF4 LBP IL6 IL17A IL10
11 response to glucocorticoid GO:0051384 9.88 TNF IL6 IL10 HSPD1
12 regulation of insulin secretion GO:0050796 9.87 TNF IL6 IFNG
13 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.87 PF4 F2 CXCL8
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.87 TNF IL6 IFNG
15 positive regulation of interleukin-8 production GO:0032757 9.87 TNF TLR2 LBP IL6
16 positive regulation of interleukin-1 beta production GO:0032731 9.86 TNF IL6 IL17A IFNG
17 humoral immune response GO:0006959 9.85 TNF IL6 IFNG
18 positive regulation of cytokine production GO:0001819 9.85 TNF IL10 IFNG
19 hemostasis GO:0007599 9.84 SERPINC1 GP1BA F2
20 response to activity GO:0014823 9.83 IL6 IL10 HSPD1
21 positive regulation of interleukin-10 production GO:0032733 9.82 TLR2 IL6 HSPD1
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.81 TNF TLR2 LBP
23 microglial cell activation GO:0001774 9.81 TNF TLR2 IFNG
24 positive regulation of interleukin-12 production GO:0032735 9.81 TLR2 IL17A IFNG HSPD1
25 acute-phase response GO:0006953 9.8 LBP IL6 F2 CRP
26 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.79 TNF IL6 IL17A
27 positive regulation of JAK-STAT cascade GO:0046427 9.78 TNF IL6 IL10 F2
28 positive regulation of osteoclast differentiation GO:0045672 9.77 TNF IL17A IFNG
29 positive regulation of macrophage activation GO:0043032 9.77 LBP IL10 HSPD1
30 blood coagulation, intrinsic pathway GO:0007597 9.76 GP1BA F2 APOH
31 defense response to Gram-positive bacterium GO:0050830 9.73 TNF TLR2 LBP IL6 IL17A CRP
32 response to molecule of bacterial origin GO:0002237 9.72 TLR2 IL10 CXCL8
33 cellular response to lipoteichoic acid GO:0071223 9.7 TLR2 LBP
34 negative regulation of fibrinolysis GO:0051918 9.7 F2 APOH
35 negative regulation of lipid storage GO:0010888 9.7 TNF IL6 CRP
36 endothelial cell apoptotic process GO:0072577 9.69 TNF IL10
37 vascular endothelial growth factor production GO:0010573 9.68 TNF IL6
38 opsonization GO:0008228 9.68 LBP CRP
39 negative regulation of MHC class II biosynthetic process GO:0045347 9.67 PF4 IL10
40 negative regulation of cytokine production involved in immune response GO:0002719 9.67 TNF IL10
41 positive regulation of interleukin-23 production GO:0032747 9.65 IL17A IFNG
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.64 TNF IFNG
43 positive regulation of vitamin D biosynthetic process GO:0060557 9.62 TNF IFNG
44 positive regulation of nitrogen compound metabolic process GO:0051173 9.62 TNF IFNG
45 regulation of blood coagulation GO:0030193 9.62 SERPINC1 GP1BA F2 APOH
46 positive regulation of chemokine production GO:0032722 9.55 TNF TLR2 LBP IL6 IFNG
47 positive regulation of tumor necrosis factor production GO:0032760 9.43 TLR2 PF4 LBP IL6 IL17A IFNG
48 positive regulation of interleukin-6 production GO:0032755 9.17 TNF TLR2 LBP IL6 IL17A IFNG

Molecular functions related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.46 SERPINC1 PF4 F2 APOH
2 lipopeptide binding GO:0071723 9.26 TLR2 LBP
3 lipopolysaccharide binding GO:0001530 9.26 TLR2 LBP HSPD1 F2
4 cytokine activity GO:0005125 9.17 TNF PF4 IL6 IL17A IL10 IFNG
Sources

Sources for Endocarditis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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