MCID: END033
MIFTS: 60

Endocarditis

Categories: Blood diseases, Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Endocarditis

MalaCards integrated aliases for Endocarditis:

Name: Endocarditis 12 77 56 44 45 15 17 74 64

Classifications:



External Ids:

Disease Ontology 12 DOID:10314
ICD9CM 36 421.9
MeSH 45 D004696
SNOMED-CT 69 56819008 91357005
ICD10 34 I33.9

Summaries for Endocarditis

MedlinePlus : 44 Endocarditis, also called infective endocarditis (IE), is an inflammation of the inner lining of the heart. The most common type, bacterial endocarditis, occurs when germs enter your heart. These germs come through your bloodstream from another part of your body, often your mouth. Bacterial endocarditis can damage your heart valves. If untreated, it can be life-threatening. It is rare in healthy hearts. Risk factors include having An abnormal or damaged heart valve An artificial heart valve Congenital heart defects The signs and symptoms of IE can vary from person to person. They also can vary over time in the same person. Symptoms you might notice include fever, shortness of breath, fluid buildup in your arms or legs, tiny red spots on your skin, and weight loss. Your doctor will diagnose IE based on your risk factors, medical history, signs and symptoms, and lab and heart tests. Early treatment can help you avoid complications. Treatment usually involves high-dose antibiotics. If your heart valve is damaged, you may need surgery. If you're at risk for IE, brush and floss your teeth regularly, and have regular dental checkups. Germs from a gum infection can enter your bloodstream. If you are at high risk, your doctor might prescribe antibiotics before dental work and certain types of surgery. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Endocarditis is related to marantic endocarditis and infective endocarditis, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Endocarditis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Allograft rejection and Toll Comparative Pathway. The drugs Cefazolin and Dextrose USP and Rifampicin have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and brain, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Disease Ontology : 12 A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves.

PubMed Health : 64 About endocarditis: Endocarditis (EN-do-kar-DI-tis) is an infection of the inner lining of the heart chambers and valves. This lining is called the endocardium (en-do-KAR-de-um). The condition also is called infective endocarditis (IE).The term "endocarditis" also is used to describe an inflammation of the endocardium due to other conditions. This article only discusses endocarditis related to infection.IE occurs if bacteria, fungi, or other germs invade your bloodstream and attach to abnormal areas of your heart. The infection can damage your heart and cause serious and sometimes fatal complications.IE can develop quickly or slowly; it depends on what type of germ is causing it and whether you have an underlying heart problem. When IE develops quickly, it's called acute infective endocarditis. When it develops slowly, it's called subacute infective endocarditis.

Wikipedia : 77 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

Related Diseases for Endocarditis

Diseases in the Endocarditis family:

Subacute Bacterial Endocarditis

Diseases related to Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 777)
# Related Disease Score Top Affiliating Genes
1 marantic endocarditis 33.8 F2 PLAT SERPINC1
2 infective endocarditis 33.3 APOH AQP9 CRP F2 FCGR2A IL6
3 brucellosis 32.1 CRP CXCL8 IL10 IL6 TNF
4 q fever 31.5 IL10 IL6 TNF
5 rheumatic fever 31.1 IL10 IL6 TNF
6 pericarditis 31.1 CRP IL6 TNF
7 endomyocardial fibrosis 30.8 IL10 TNF
8 arthritis 30.6 CXCL8 IL10 IL6 TNF
9 spondylitis 30.5 CRP IL6 TNF
10 limb ischemia 30.5 IL6 TNF TNNI3
11 mycobacterium fortuitum 30.5 CXCL8 HSPD1 LACTB
12 myocarditis 30.5 IL6 TNF TNNI3
13 pericardial effusion 30.5 CRP IL6 PIK3C2A
14 adult-onset still's disease 30.4 CRP IL6 TNF
15 lupus erythematosus 30.4 APOH FCGR2A IL10 TNF
16 osteomyelitis 30.4 CXCL8 IL10 IL6 TNF
17 rheumatic heart disease 30.3 IL10 IL6 TNF VCAM1
18 heparin-induced thrombocytopenia 30.2 FCGR2A SERPINC1
19 intracranial embolism 30.2 F2 PLAT SERPINC1
20 temporal arteritis 30.2 APOH CRP IL6 TNF
21 dermatitis, atopic 30.2 CXCL8 EPX IL10 TNF
22 end stage renal failure 30.1 ALB CRP IL6 TNF
23 drug reaction with eosinophilia and systemic symptoms 30.1 CRP TNF
24 fasciitis 30.1 CXCL8 IL6 TNF
25 vasculitis 30.1 APOH CRP TNF VCAM1
26 melioidosis 30.1 IL10 IL6 TNF
27 thrombosis 30.1 APOH F2 PLAT SERPINC1
28 autoimmune myocarditis 30.1 IL6 TNF
29 human immunodeficiency virus infectious disease 30.1 IL10 IL6 TNF
30 purpura 30.1 APOH CRP F2 IL6 SERPINC1 TNF
31 acquired immunodeficiency syndrome 30.1 ALB IL10 IL6 TNF
32 sudden sensorineural hearing loss 30.0 APOH F2 IL6
33 acute cystitis 30.0 ALB CRP CXCL8 IL6
34 colitis 29.9 CXCL8 IL10 IL6 TNF
35 protein s deficiency 29.9 APOH F2 SERPINC1
36 typhoid fever 29.9 ALB CRP F2 IL6 TNF
37 echinococcosis 29.9 IL10 IL6 TNF
38 meningitis 29.9 ALB CRP CXCL8 FCGR2A IL10 IL6
39 complex regional pain syndrome 29.9 IL10 IL6 TNF
40 myeloma, multiple 29.9 ALB CRP CXCL8 IL6 TNF
41 polyarteritis nodosa 29.9 APOH CRP IL6
42 patent foramen ovale 29.8 APOH F2 PLAT SERPINC1
43 pyelonephritis 29.8 ALB CRP CXCL8 IL10 IL6 TNF
44 disseminated intravascular coagulation 29.8 F2 PIK3C2A PLAT SERPINC1
45 diabetes mellitus 29.8 ALB CRP HSPD1 IL6 PIK3C2A TNF
46 kawasaki disease 29.8 ALB CRP FCGR2A HSPD1 IL10 IL6
47 cardiogenic shock 29.8 IL6 PIK3C2A PLAT TNF
48 alcoholic liver cirrhosis 29.8 ALB CXCL8 F2
49 pneumonia 29.8 CRP CXCL8 IL10 IL6 LACTB PIK3C2A
50 spinal cord injury 29.8 CXCL8 IL6 TNF

Graphical network of the top 20 diseases related to Endocarditis:



Diseases related to Endocarditis

Symptoms & Phenotypes for Endocarditis

UMLS symptoms related to Endocarditis:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Endocarditis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ALB CXCL8 FCGR2A HSPD1 PIK3C2A SERPINC1

MGI Mouse Phenotypes related to Endocarditis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 AQP9 EPX F2 FCGR2A IL10 IL6
2 cardiovascular system MP:0005385 10.02 CRP F2 IL10 IL6 PIK3C2A PLAT
3 homeostasis/metabolism MP:0005376 9.97 ALB APOH AQP9 CRP F2 IL10
4 immune system MP:0005387 9.77 AQP9 CRP EPX F2 FCGR2A IL10
5 mortality/aging MP:0010768 9.44 ALB APOH F2 FCGR2A HSPD1 IL10

Drugs & Therapeutics for Endocarditis

PubMedHealth treatment related to Endocarditis: 64

Infective endocarditis (IE) is treated with antibiotics and sometimes with heart surgery.

FDA approved drugs:

# Drug Name Active Ingredient(s) 19 Company Approval Date
1
Cefazolin and Dextrose USP 19 CEFAZOLIN SODIUM B Braun Medical July 2000

Drugs for Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 241)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifampicin Approved Phase 4,Phase 3 13292-46-1 5381226 5458213
2
Vancomycin Approved Phase 4,Phase 3,Phase 2,Not Applicable 1404-90-6 441141 14969
3
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
4
Daptomycin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 103060-53-3 16129629
5
Ceftaroline fosamil Approved, Investigational Phase 4,Phase 1 229016-73-3
6
Fosfomycin Approved Phase 4 23155-02-4 446987
7
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
8
Racepinephrine Approved Phase 4 329-65-7 838
9
Hexetidine Approved, Investigational Phase 4 141-94-6
10
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
11
Chlorhexidine Approved, Vet_approved Phase 4,Not Applicable 55-56-1 2713 9552079
12
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613
13
Warfarin Approved Phase 4,Not Applicable 81-81-2 6691 54678486
14
Cephalexin Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 15686-71-2 27447
15
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
16
Clopidogrel Approved Phase 4,Not Applicable 120202-66-6, 113665-84-2 60606
17
Rivaroxaban Approved Phase 4,Not Applicable 366789-02-8
18
Edoxaban Approved Phase 4,Not Applicable 480449-70-5
19
Apixaban Approved Phase 4,Not Applicable 503612-47-3 10182969
20
Aspirin Approved, Vet_approved Phase 4,Not Applicable 50-78-2 2244
21
Phenprocoumon Approved, Investigational Phase 4 435-97-2 9908 54680692
22
Linezolid Approved, Investigational Phase 4,Phase 3 165800-03-3 441401
23
Oritavancin Approved, Investigational Phase 4 171099-57-3 16129632
24
Serine Approved, Nutraceutical Phase 4,Not Applicable 56-45-1 5951
25
Dabigatran Investigational Phase 4,Not Applicable 211914-51-1
26 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Not Applicable
28 methicillin Phase 4,Phase 3,Phase 2
29 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable
31 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable
32 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
33 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
34 Sodium Channel Blockers Phase 4,Phase 2
35 Anti-Arrhythmia Agents Phase 4,Phase 2
36 Anesthetics, Local Phase 4,Phase 2
37 Diuretics, Potassium Sparing Phase 4,Phase 2
38 Antirheumatic Agents Phase 4,Phase 2,Not Applicable
39 Analgesics, Non-Narcotic Phase 4,Phase 2,Not Applicable
40 Analgesics Phase 4,Phase 2,Not Applicable
41 Cyclooxygenase Inhibitors Phase 4,Phase 2,Not Applicable
42 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Not Applicable
43 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable
44 beta-Lactams Phase 4
45 Lactams Phase 4
46 Adrenergic beta-Agonists Phase 4
47 Chlorhexidine gluconate Phase 4,Not Applicable
48 Anti-Infective Agents, Local Phase 4,Not Applicable
49 Mydriatics Phase 4
50 Autonomic Agents Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 245)
# Name Status NCT ID Phase Drugs
1 Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study (ENDOVAL) Unknown status NCT00624091 Phase 4
2 Pharmacokinetics/ Pharmacodynamics (PK/PD) Study of Vancomycin Unknown status NCT02443064 Phase 4 Vancomycin
3 Duration of Antibiotic Therapy in Community - Acquired Pneumonia Unknown status NCT01492387 Phase 4
4 Partial Oral Treatment of Endocarditis Completed NCT01375257 Phase 4 Oral treatment with antibiotics for endocarditis;Guideline treatment with parenteral antibiotics
5 Early Surgery Versus Conventional Treatment in Infective Endocarditis Completed NCT00750373 Phase 4
6 Fosfomycin Plus Imipenem for Treatment of Infective Endocarditis Completed NCT00871104 Phase 4 Fosfomycin and imipenem;Vancomycin
7 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Completed NCT01920126 Phase 4 sodium bicarbonate;Saline
8 Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections Completed NCT00709358 Phase 4
9 Bacteraemia Secondary to Tooth Extraction: Chlorhexidine Prophylaxis Protocols Completed NCT02150031 Phase 4 0.2% Chlorhexidine;1% Chlorhexidine;1% Chlorhexidine;Lidocaine plus adrenaline
10 Bacteremia in Periodontal Patients Completed NCT02215473 Phase 4 Chlorhexidine gluconate mouth rinse
11 World-wide Randomized Antibiotic Envelope Infection Prevention Trial Completed NCT02277990 Phase 4
12 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Recruiting NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
13 An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Dental Procedures Recruiting NCT02783404 Phase 4 Amoxicillin;Amoxicillin-Potassium Clavulanate
14 Daptomycin as Adjunctive Therapy for Staphylococcus Aureus Bacteremia Recruiting NCT02972983 Phase 4 Daptomycin
15 Left Atrial Appendage CLOSURE in Patients With Atrial Fibrillation Compared to Medical Therapy Recruiting NCT03463317 Phase 4 Acetylsalicylic acid;Clopidogrel;Dabigatran;Rivaroxaban;Apixaban;Edoxaban;Phenprocoumon;Warfarin
16 Oritavancin for Staphylococcus Aureus Infections in Opioid Users Not yet recruiting NCT03761953 Phase 4 Oritavancin Injection
17 Impact of Antibiotic Treatment Following Implantation of Cardiac Electronic Device on Patient's Outcome Not yet recruiting NCT03148444 Phase 4 cefalexin 500 mg qid or roxithromycin 150 mg bid
18 Daptomycin as an Adjuvant Agent in the Treatment of Enterococcal Native Valve Endocarditis. Terminated NCT00401960 Phase 4 Daptomycin
19 Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE) Terminated NCT00638157 Phase 4 daptomycin;daptomycin and gentamicin
20 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
21 The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study Terminated NCT00164099 Phase 4 Synbiotic 2000
22 TRANscatheter or SurgIcal Aortic Valve ReplacemenT in All-Comers With Severe Aortic Valve Stenosis Withdrawn NCT02838199 Phase 4
23 Safety and Effectiveness Study of Perceval S Valve for Extended CE Mark Unknown status NCT01368666 Phase 2, Phase 3
24 Efficacy and Safety of Venus P-valve to Treat RVOT Stenosis With Pulmonary Regurgitation Unknown status NCT02071654 Phase 3
25 Minimally Invasive Transthoracic Device Closure in Perimembranous Ventricular Septal Defect Unknown status NCT02644330 Phase 2, Phase 3
26 Multi-center Trial of Percutaneous Pulmonary Valve Implantation With Venus-p Unknown status NCT02590679 Phase 2, Phase 3
27 Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus Completed NCT00093067 Phase 3 daptomycin
28 A Study of MK-3009 in Japanese Patients With Skin or Blood Stream Infections Caused by Methicillin-resistant Staphylococcus Aureus (MK-3009-002) Completed NCT00770341 Phase 3 Daptomycin 4 mg/kg;Comparator: vancomycin;Daptomycin 6 mg/kg
29 Population Pharmacokinetic (PK) Study of Multiple Doses of Cubicin® (Daptomycin) 10 mg/kg in Critical Care Patients Having Bacteremia, Endocarditis or Skin Soft Tissue Infections Due to Gram Positive Bacteria With Various Degrees of Renal Failure Completed NCT02142075 Phase 3 Daptomycin
30 Conservative Aortic Valve Surgery for Aortic Insufficiency and Aneurysms of the Aortic Root. CAVIAAR Completed NCT00478803 Phase 3
31 Early Antiretroviral Treatment and/or Early Isoniazid Prophylaxis Against Tuberculosis in HIV-infected Adults (ANRS 12136 TEMPRANO) Completed NCT00495651 Phase 3 Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis;Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis
32 Strategies Using Off-Patent Antibiotics for Methicillin Resistant S. Aureus "STOP MRSA" Completed NCT00729937 Phase 2, Phase 3 Cephalexin;Clindamycin;Trimethoprim-sulfamethoxazole
33 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus Recruiting NCT02701595 Phase 3 Amoxicillin
34 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus Recruiting NCT02701608 Phase 3 Levofloxacin;Rifampicin
35 Ceftobiprole in the Treatment of Patients With Staphylococcus Aureus Bacteremia Recruiting NCT03138733 Phase 3 Ceftobiprole medocaril;Daptomycin
36 Staphylococcus Aureus Bacteremia Antibiotic Treatment Options Recruiting NCT01792804 Phase 3 Trimethoprim-Sulfamethoxazole;Clindamycin;Linezolid;Flucloxacillin;Cloxacillin;Vancomycin;Daptomycin;Cefazolin
37 Transfer Factor Efficacy in the Management of Cirrhosis-associated Immune Dysfunction Recruiting NCT02837939 Phase 2, Phase 3 Human derived Transfer factor;Aqua pro injectione 4ml ampules for subcutaneous injection
38 STeroids to REduce Systemic Inflammation After Neonatal Heart Surgery Recruiting NCT03229538 Phase 3 Methylprednisolone;Isotonic saline
39 Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction. Recruiting NCT02836899 Phase 3 Nitric Oxide
40 A Phase 3 Telavancin Staphylococcus Aureus (S. Aureus) Bacteremia Trial Terminated NCT02208063 Phase 3 Telavancin;Vancomycin;Daptomycin;Synthetic penicillin;Cefazolin
41 Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections Terminated NCT00108433 Phase 3 Cefazolin IV;Linezolid IV;Vancomycin (IV)
42 Perioperative Ketorolac-lidocaine in the Patients With Valvular Heart Diseases During Cesarean Delivery Unknown status NCT01571791 Phase 2 Placebo;Ketorolac-Lidocaine
43 TranScatheter Aortic Valve RepLacement System US Feasibility Trial Unknown status NCT01932099 Phase 2
44 Bacteria Entering the Blood Stream From Tooth Extractions and Tooth Brushing Completed NCT00454285 Phase 2 Effect of Amoxicillin on bacteremia following a single-tooth extraction
45 Safety Evaluation of a Q-fever Vaccine, NDBR 105 Completed NCT00584454 Phase 2
46 Feasibility Study of a Percutaneous Mitral Valve Repair System. Completed NCT00209339 Phase 1, Phase 2
47 Assessment of Radiolabeled rhAnnexin V-128 in Infective Endocarditis Recruiting NCT02459613 Phase 1, Phase 2
48 Neonatal Vancomycin Trial Recruiting NCT02790996 Phase 2 Vancomycin
49 Surgical Implantation of TRAnscatheter vaLve in Native Mitral Annular Calcification (SITRAL) Study Recruiting NCT02830204 Phase 1, Phase 2
50 Evaluation of an Antibiotic Regimen Pharmacokinetic Applicable to Enterococcus Faecalis Infective Endocarditis Active, not recruiting NCT03681431 Phase 2 Ceftriaxone 4g/ 24h;Ceftriaxone 2g/ 12h

Search NIH Clinical Center for Endocarditis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: endocarditis

Genetic Tests for Endocarditis

Anatomical Context for Endocarditis

MalaCards organs/tissues related to Endocarditis:

42
Heart, Skin, Brain, Testes, Liver, Kidney, Colon

Publications for Endocarditis

Articles related to Endocarditis:

(show top 50) (show all 6560)
# Title Authors Year
1
Rothia dentocariosa Endocarditis in an Unsuspecting Host: A Case Report and Literature Review. ( 30809399 )
2019
2
Efficacy of teicoplanin monotherapy following initial standard therapy in Enterococcus faecalis infective endocarditis: a retrospective cohort study. ( 30809761 )
2019
3
Spodiobacter cordis gen. nov. sp. nov., a member of the family Flavobacteriaceae isolated from patients with infective endocarditis. ( 30817020 )
2019
4
Intravenous Drug Use-Associated Endocarditis Complicating Research of Antibiotic Prophylaxis and Guideline Recommendations. ( 30819369 )
2019
5
Reply: Intravenous Drug Use-Associated Endocarditis Complicating Research of Antibiotic Prophylaxis and Guideline Recommendations. ( 30819370 )
2019
6
D-Dimer is a strong predictor of in-hospital mortality in patients with infective endocarditis. ( 30821726 )
2019
7
An Occult Aortocavitary Fistula Presenting as Apparent Tricuspid Valve and Aortic Valve Endocarditis. ( 30828681 )
2019
8
Successful treatment of Pseudomonas aeruginosa infective endocarditis via haemodialysis outpatient parenteral antimicrobial therapy: case report. ( 30830217 )
2019
9
Infective endocarditis in chronic hemodialysis patients is it still a growing clinical challenge? ( 30830890 )
2019
10
Response: Fundamental role of echocardiographic evaluation in the diagnosis of prosthetic valve endocarditis. ( 30834557 )
2019
11
Acute ST-elevation myocardial infarction due to prosthetic valve endocarditis after transcatheter aortic valve implantation. ( 30836743 )
2019
12
Repair of left ventricular pseudoaneurysm from mitral valve endocarditis. ( 30843076 )
2019
13
Pauci-immune proliferative glomerulonephritis and fungal endocarditis: More than a mere coincidence? ( 30846459 )
2019
14
Diagnostic challenges in infective endocarditis: is PET/CT the solution? ( 30847769 )
2019
15
In-host evolution of Staphylococcus epidermidis in a pacemaker-associated endocarditis resulting in increased antibiotic tolerance. ( 30850614 )
2019
16
Be careful about MICs to amoxicillin for patients with Streptococci-related infective endocarditis. ( 30851401 )
2019
17
Severe tricuspid valve destruction secondary to previous non-appropriately treated endocarditis. ( 30852499 )
2019
18
Tricuspid Valve Infective Endocarditis Due to Klebsiella pneumoniae in Intravenous Drug User. ( 30854255 )
2019
19
Evaluation of failed prosthetic valves in the valve-in-valve era: Potential for utilizing positron emission tomography/computed tomography to recognize infective endocarditis. ( 30856285 )
2019
20
Assessment of the feasibility of a partial oral regimen for antibiotic therapy of endocarditis. ( 30864091 )
2019
21
Duration and complications of diabetes mellitus and the associated risk of infective endocarditis. ( 30291010 )
2019
22
Plasmapheresis and corticosteroids in infective endocarditis-related crescentic glomerulonephritis. ( 30872338 )
2019
23
Value of cardiac computed tomography angiography in pre-operative assessment of infective endocarditis. ( 30866989 )
2019
24
Clot Histopathology in Ischemic Stroke with Infective Endocarditis. ( 30867075 )
2019
25
Antimicrobial management of Tropheryma whipplei endocarditis: the Spanish Collaboration on Endocarditis (GAMES) experience. ( 30869125 )
2019
26
99mTc-Besilesomab-SPECT/CT in Infectious Endocarditis: Upgrade of a Forgotten Method? ( 30873410 )
2019
27
Giant vegetation in mitral prosthetic heart valve endocarditis. ( 30874506 )
2019
28
Endocarditis after percutaneous edge-to-edge in a heart transplant recipient: management through the HeartPort technique. ( 30879051 )
2019
29
Outcome for surgical treatment of infective endocarditis with periannular abscess. ( 30879717 )
2019
30
Prosthetic Valve Legionella Endocarditis. ( 30880136 )
2019
31
Myocarditis Caused by Brucella melitensis in the Absence of Endocarditis: Case Report and Review of the Literature. ( 30881458 )
2019
32
The 18-fluorine-fluorodeoxyglucose positron-emission-tomography/computed tomography-guided treatment of prosthetic valve endocarditis. ( 30882194 )
2019
33
Long-Term Outcomes of Partial Oral Treatment of Endocarditis. ( 30883059 )
2019
34
Mitral valve endocarditis-Unrealized expectations for repair of mitral valve. ( 30885624 )
2019
35
Mitral valve repair versus replacement for infective endocarditis, again. ( 30885627 )
2019
36
Clinical hallmarks making diagnosis of infective endocarditis. ( 30887385 )
2019
37
ST-Elevation Myocardial Infarction Associated With Infective Endocarditis. ( 30890259 )
2019
38
Subacute Aerococcus urinae Infective Endocarditis With Mycotic Aneurysms in a Pediatric Patient: Case Report and Literature Review. ( 30892601 )
2019
39
Blocking a rash diagnosis: a rare case of infective endocarditis. ( 30898951 )
2019
40
Group C Streptococcus dysgalactiae subsp.equisimilis (SDSE) Endocarditis with Endogenous Endophthalmitis and Aortic Root Abscess. ( 30899671 )
2019
41
Whipple's endocarditis diagnosed by thrombus analysis retrieved by successful mechanical thrombectomy. ( 30901568 )
2019
42
Commentary: Goals of surgical therapy in tricuspid valve endocarditis. ( 30901790 )
2019
43
Role of age and comorbidities in mortality of patients with infective endocarditis. ( 30904433 )
2019
44
Nursing Home Admission and Initiation of Domiciliary Care Following Infective Endocarditis. ( 30905692 )
2019
45
Management of endocarditis among persons who inject drugs: A narrative review of surgical and psychiatric approaches and controversies. ( 30908961 )
2019
46
Right-sided endocarditis from Staphylococcus lugdunensis in a patient with tetralogy of Fallot. ( 30915201 )
2019
47
Trends in Epidemiology: Analysis of Risk Factors and Outcomes of Infective Endocarditis: A Retrospective Study (2009-2015). ( 30915267 )
2019
48
Addressing limitations of partial oral treatment of left-sided infectious endocarditis (POET) criteria for prosthetic valve endocarditis: a note of caution. ( 30916328 )
2019
49
Infective Endocarditis Due to Treponema pallidum: A Case Diagnosed Using Polymerase Chain Reaction Analysis of Aortic Valve. ( 30595174 )
2019
50
Candida Endocarditis after TAVR. ( 30601749 )
2019

Variations for Endocarditis

Expression for Endocarditis

Search GEO for disease gene expression data for Endocarditis.

Pathways for Endocarditis

Pathways related to Endocarditis according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.82 CXCL8 EPX HSPD1 IL10 IL6 TNF
2
Show member pathways
12.24 CXCL8 IL6 LBP TNF
3
Show member pathways
12.18 ALB CRP F2 IL6 PLAT TNF
4
Show member pathways
12.14 CXCL8 IL6 LBP TNF
5 12.1 CXCL8 HSPD1 IL10 IL6 TNF
6 12.05 FCGR2A HSPD1 IL10 IL6 LBP TNF
7 12.02 ALB IL6 TNNI3 VCAM1
8 11.96 CXCL8 FCGR2A IL6 TNF
9 11.9 CEACAM8 FCGR2A IL10 IL6 TNF
10 11.87 CXCL8 IL6 TNF VCAM1
11 11.84 CXCL8 IL10 IL6 TNF
12 11.83 CXCL8 LBP TNF VCAM1
13
Show member pathways
11.8 CXCL8 IL6 LBP
14 11.78 CXCL8 IL6 TNF
15 11.75 CXCL8 IL6 LBP
16
Show member pathways
11.73 F2 FCGR2A HSPD1 IL6 PLAT TNF
17 11.72 CXCL8 IL10 IL6 TNF
18 11.68 IL10 IL6 TNF
19 11.68 FCGR2A IL10 IL6 TNF
20
Show member pathways
11.61 CXCL8 IL6 TNF VCAM1
21 11.6 CXCL8 IL6 TNF
22 11.52 CXCL8 HSPD1 IL6 TNF
23 11.47 IL6 PLAT TNF
24 11.45 CXCL8 IL10 IL6 TNF
25 11.31 IL10 IL6 TNF
26 11.27 IL10 IL6 TNF VCAM1
27 11.21 IL10 IL6 TNF
28 11.16 CXCL8 IL10 IL6 LBP TNF VCAM1
29 11.15 CXCL8 IL10 IL6 TNF
30 11.04 CXCL8 IL10 IL6 TNF VCAM1
31 10.84 CRP CXCL8 IL6 TNF

GO Terms for Endocarditis

Cellular components related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.9 ALB APOH CEACAM8 EPX F2 HSPD1
2 cell surface GO:0009986 9.8 APOH CEACAM8 HSPD1 LBP PLAT TNF
3 extracellular region GO:0005576 9.73 ALB APOH CRP CXCL8 EPX F2
4 extracellular space GO:0005615 9.5 ALB APOH CEACAM8 CRP CXCL8 EPX

Biological processes related to Endocarditis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.99 CXCL8 F2 IL10 IL6 TNF
2 inflammatory response GO:0006954 9.96 CRP CXCL8 IL10 IL6 TNF
3 defense response to bacterium GO:0042742 9.92 EPX IL10 LBP TNF
4 cellular protein metabolic process GO:0044267 9.9 ALB F2 IL6 SERPINC1
5 defense response to Gram-positive bacterium GO:0050830 9.81 CRP IL6 LBP TNF
6 cellular response to lipopolysaccharide GO:0071222 9.77 CXCL8 IL10 IL6 LBP TNF
7 response to lipopolysaccharide GO:0032496 9.72 IL10 LBP VCAM1
8 response to organic substance GO:0010033 9.67 AQP9 IL10 TNF
9 positive regulation of chemokine production GO:0032722 9.65 IL6 LBP TNF
10 positive regulation of blood coagulation GO:0030194 9.63 APOH F2
11 response to molecule of bacterial origin GO:0002237 9.63 CXCL8 IL10
12 positive regulation of macrophage activation GO:0043032 9.63 HSPD1 IL10 LBP
13 cytokine-mediated signaling pathway GO:0019221 9.63 CXCL8 IL10 IL6 LBP TNF VCAM1
14 plasminogen activation GO:0031639 9.62 APOH PLAT
15 negative regulation of fibrinolysis GO:0051918 9.61 APOH F2
16 opsonization GO:0008228 9.61 CRP LBP
17 response to glucocorticoid GO:0051384 9.61 IL10 IL6 TNF
18 endothelial cell apoptotic process GO:0072577 9.58 IL10 TNF
19 negative regulation of cytokine secretion involved in immune response GO:0002740 9.58 IL10 TNF
20 negative regulation of growth of symbiont in host GO:0044130 9.58 IL10 LBP TNF
21 positive regulation of neuroinflammatory response GO:0150078 9.57 IL6 TNF
22 positive regulation of interleukin-6 production GO:0032755 9.56 HSPD1 IL6 LBP TNF
23 receptor biosynthetic process GO:0032800 9.54 IL10 TNF
24 regulation of blood coagulation GO:0030193 9.5 APOH F2 SERPINC1
25 negative regulation of lipid storage GO:0010888 9.13 CRP IL6 TNF
26 acute-phase response GO:0006953 8.92 CRP F2 IL6 LBP
27 immune response GO:0006955 10 AQP9 CEACAM8 CXCL8 IL10 IL6 TNF

Molecular functions related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CXCL8 IL10 IL6 TNF
2 lipopolysaccharide binding GO:0001530 8.8 F2 HSPD1 LBP

Sources for Endocarditis

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