MCID: END033
MIFTS: 60

Endocarditis

Categories: Blood diseases, Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Endocarditis

MalaCards integrated aliases for Endocarditis:

Name: Endocarditis 12 76 55 43 44 15 63 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10314
ICD10 33 I33.9
ICD9CM 35 421.9
MeSH 44 D004696
SNOMED-CT 68 56819008 91357005

Summaries for Endocarditis

MedlinePlus : 43 Endocarditis, also called infective endocarditis (IE), is an inflammation of the inner lining of the heart. The most common type, bacterial endocarditis, occurs when germs enter your heart. These germs come through your bloodstream from another part of your body, often your mouth. Bacterial endocarditis can damage your heart valves. If untreated, it can be life-threatening. It is rare in healthy hearts. Risk factors include having An abnormal or damaged heart valve An artificial heart valve Congenital heart defects The signs and symptoms of IE can vary from person to person. They also can vary over time in the same person. Symptoms you might notice include fever, shortness of breath, fluid buildup in your arms or legs, tiny red spots on your skin, and weight loss. Your doctor will diagnose IE based on your risk factors, medical history, signs and symptoms, and lab and heart tests. Early treatment can help you avoid complications. Treatment usually involves high-dose antibiotics. If your heart valve is damaged, you may need surgery. If you're at risk for IE, brush and floss your teeth regularly, and have regular dental checkups. Germs from a gum infection can enter your bloodstream. If you are at high risk, your doctor might prescribe antibiotics before dental work and certain types of surgery. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Endocarditis is related to infective endocarditis and brucellosis, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Endocarditis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. The drugs Cefazolin and Dextrose USP and Rifampicin have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and lung, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Disease Ontology : 12 A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves.

PubMed Health : 63 About endocarditis: Endocarditis (EN-do-kar-DI-tis) is an infection of the inner lining of the heart chambers and valves. This lining is called the endocardium (en-do-KAR-de-um). The condition also is called infective endocarditis (IE).The term "endocarditis" also is used to describe an inflammation of the endocardium due to other conditions. This article only discusses endocarditis related to infection.IE occurs if bacteria, fungi, or other germs invade your bloodstream and attach to abnormal areas of your heart. The infection can damage your heart and cause serious and sometimes fatal complications.IE can develop quickly or slowly; it depends on what type of germ is causing it and whether you have an underlying heart problem. When IE develops quickly, it's called acute infective endocarditis. When it develops slowly, it's called subacute infective endocarditis.

Wikipedia : 76 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

Related Diseases for Endocarditis

Diseases in the Endocarditis family:

Subacute Bacterial Endocarditis

Diseases related to Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 740)
# Related Disease Score Top Affiliating Genes
1 infective endocarditis 33.2 TNNI3 TNF TLR2 LBP IL6 FCGR2A
2 brucellosis 32.0 CRP CXCL8 IL10 IL6 TNF
3 rheumatic fever 30.8 IL10 IL6 TNF
4 q fever 30.7 IL10 IL6 TLR2 TNF
5 pericarditis 30.7 CRP IL6 TNF
6 endomyocardial fibrosis 30.5 IL10 TNF
7 arthritis 30.4 CXCL8 IL10 IL6 TNF
8 mycobacterium fortuitum 30.4 CXCL8 HSPD1 LACTB
9 lupus erythematosus 30.3 APOH FCGR2A IL10 TNF
10 patent foramen ovale 30.2 APOH F2 SERPINC1
11 antiphospholipid syndrome 30.2 APOH F2 SERPINC1 VCAM1
12 adult-onset still's disease 30.2 CRP IL6 TNF
13 disseminated intravascular coagulation 30.2 F2 PIK3C2A SERPINC1
14 pericardial effusion 30.2 CRP IL6 PIK3C2A
15 stroke, ischemic 30.2 APOH CRP F2 SERPINC1
16 septic arthritis 30.2 CRP CXCL8 TLR2
17 myocarditis 30.2 IL6 TNF TNNI3
18 rheumatic heart disease 30.1 IL10 IL6 TNF VCAM1
19 spondylitis 30.1 CRP IL6 TNF
20 microscopic polyangiitis 30.1 IL10 TNF
21 limb ischemia 30.1 IL6 TNF TNNI3
22 osteomyelitis 30.1 CXCL8 IL10 IL6 TNF
23 cardiogenic shock 30.1 IL6 PIK3C2A TNF
24 temporal arteritis 30.1 APOH CRP IL6 TNF
25 pulmonary embolism 30.1 ALB APOH CRP F2 SERPINC1 TNNI3
26 ischemic heart disease 30.1 TNF IL6 CRP
27 vasculitis 30.0 VCAM1 TNF CRP APOH
28 purpura 30.0 APOH CRP F2 IL6 SERPINC1 TNF
29 mycobacterium chelonae 30.0 CXCL8 TLR2
30 aspergillosis 30.0 IL10 TLR2 TNF
31 kawasaki disease 30.0 ALB CRP FCGR2A HSPD1 IL10 IL6
32 end stage renal failure 29.9 ALB CRP IL6 TNF
33 acute myocardial infarction 29.9 CRP PIK3C2A SERPINC1 TNNI3
34 heparin-induced thrombocytopenia 29.9 FCGR2A SERPINC1
35 trench fever 29.8 TLR2 TNF
36 fasciitis 29.8 CXCL8 IL6 TNF
37 sudden sensorineural hearing loss 29.8 APOH F2 IL6
38 acute cystitis 29.8 ALB CRP CXCL8 IL6
39 mycobacterium abscessus 29.8 TNF TLR2 CXCL8
40 protein s deficiency 29.8 APOH F2 SERPINC1
41 heart disease 29.7 ALB CRP CXCL8 F2 IL10 IL6
42 myocardial infarction 29.7 ALB CRP F2 IL10 IL6 PIK3C2A
43 thrombophlebitis 29.7 SERPINC1 F2 APOH
44 meningitis 29.7 TNF TLR2 LACTB IL6 IL10 FCGR2A
45 bacterial pneumonia 29.7 CRP CXCL8 IL6 LACTB
46 complex regional pain syndrome 29.7 IL10 IL6 TNF
47 polyarteritis nodosa 29.6 APOH CRP IL6
48 myeloma, multiple 29.6 ALB CRP CXCL8 IL6 TNF
49 colitis 29.6 CXCL8 IL10 IL6 TNF
50 haemophilus influenzae 29.6 CXCL8 TLR2 TNF

Graphical network of the top 20 diseases related to Endocarditis:



Diseases related to Endocarditis

Symptoms & Phenotypes for Endocarditis

UMLS symptoms related to Endocarditis:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Endocarditis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ALB CXCL8 FCGR2A HSPD1 PIK3C2A SERPINC1

MGI Mouse Phenotypes related to Endocarditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 AQP9 EPX F2 FCGR2A IL10 IL6
2 cardiovascular system MP:0005385 10.07 CRP F2 IL10 IL6 PIK3C2A SERPINC1
3 homeostasis/metabolism MP:0005376 10.07 ALB APOH AQP9 CRP F2 IL10
4 immune system MP:0005387 9.97 AQP9 CRP EPX F2 FCGR2A IL10
5 liver/biliary system MP:0005370 9.5 ALB IL10 IL6 LBP SERPINC1 TLR2
6 mortality/aging MP:0010768 9.44 ALB APOH F2 FCGR2A HSPD1 IL10

Drugs & Therapeutics for Endocarditis

PubMedHealth treatment related to Endocarditis: 63

Infective endocarditis (IE) is treated with antibiotics and sometimes with heart surgery.

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Cefazolin and Dextrose USP 18 CEFAZOLIN SODIUM B Braun Medical July 2000

Drugs for Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 237)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifampicin Approved Phase 4,Phase 3 13292-46-1 5458213 5381226
2
Vancomycin Approved Phase 4,Phase 3,Phase 2,Not Applicable 1404-90-6 14969 441141
3
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
4
Daptomycin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 103060-53-3 16129629
5
Fosfomycin Approved Phase 4 23155-02-4 446987
6
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
7
Hexetidine Approved, Investigational Phase 4 141-94-6
8
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
9
Racepinephrine Approved Phase 4 329-65-7 838
10
Chlorhexidine Approved, Vet_approved Phase 4,Not Applicable 55-56-1 2713 9552079
11
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613
12
Warfarin Approved Phase 4,Not Applicable 81-81-2 6691 54678486
13
Cephalexin Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 15686-71-2 27447
14
Apixaban Approved Phase 4,Not Applicable 503612-47-3 10182969
15 Edoxaban Approved Phase 4,Not Applicable 480449-70-5
16
Aspirin Approved, Vet_approved Phase 4,Not Applicable 50-78-2 2244
17
Phenprocoumon Approved, Investigational Phase 4 435-97-2 54680692 9908
18
Rivaroxaban Approved Phase 4,Not Applicable 366789-02-8
19
Clopidogrel Approved Phase 4,Not Applicable 113665-84-2, 120202-66-6 60606
20
Linezolid Approved, Investigational Phase 4,Phase 3 165800-03-3 441401
21
Serine Approved, Nutraceutical Phase 4,Not Applicable 56-45-1 5951
22 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Not Applicable
23 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
24 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
25 methicillin Phase 4,Phase 3,Phase 2
26 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable
27 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable
28 Anti-Arrhythmia Agents Phase 4,Phase 2
29 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
30 Anesthetics, Local Phase 4,Phase 2
31 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
32 Diuretics, Potassium Sparing Phase 4,Phase 2
33 Sodium Channel Blockers Phase 4,Phase 2
34 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable
35 Analgesics, Non-Narcotic Phase 4,Phase 2,Not Applicable
36 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Not Applicable
37 Cyclooxygenase Inhibitors Phase 4,Phase 2,Not Applicable
38 Antirheumatic Agents Phase 4,Phase 2,Not Applicable
39 Analgesics Phase 4,Phase 2,Not Applicable
40 beta-Lactams Phase 4
41 Lactams Phase 4
42 Vasoconstrictor Agents Phase 4
43 Pharmaceutical Solutions Phase 4
44 Adrenergic alpha-Agonists Phase 4,Not Applicable
45 Adrenergic beta-Agonists Phase 4
46 Chlorhexidine gluconate Phase 4,Not Applicable
47 Anti-Asthmatic Agents Phase 4,Phase 3
48 Disinfectants Phase 4,Not Applicable
49 Adrenergic Agents Phase 4,Not Applicable
50 Mydriatics Phase 4

Interventional clinical trials:

(show top 50) (show all 234)
# Name Status NCT ID Phase Drugs
1 Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study (ENDOVAL) Unknown status NCT00624091 Phase 4
2 Pharmacokinetics/ Pharmacodynamics (PK/PD) Study of Vancomycin Unknown status NCT02443064 Phase 4 Vancomycin
3 Duration of Antibiotic Therapy in Community - Acquired Pneumonia Unknown status NCT01492387 Phase 4
4 Partial Oral Treatment of Endocarditis Completed NCT01375257 Phase 4 Oral treatment with antibiotics for endocarditis;Guideline treatment with parenteral antibiotics
5 Early Surgery Versus Conventional Treatment in Infective Endocarditis Completed NCT00750373 Phase 4
6 Fosfomycin Plus Imipenem for Treatment of Infective Endocarditis Completed NCT00871104 Phase 4 Fosfomycin and imipenem;Vancomycin
7 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Completed NCT01920126 Phase 4 sodium bicarbonate;Saline
8 Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections Completed NCT00709358 Phase 4
9 Bacteraemia Secondary to Tooth Extraction: Chlorhexidine Prophylaxis Protocols Completed NCT02150031 Phase 4 0.2% Chlorhexidine;1% Chlorhexidine;1% Chlorhexidine;Lidocaine plus adrenaline
10 Bacteremia in Periodontal Patients Completed NCT02215473 Phase 4 Chlorhexidine gluconate mouth rinse
11 World-wide Randomized Antibiotic Envelope Infection Prevention Trial Completed NCT02277990 Phase 4
12 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Recruiting NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
13 An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Dental Procedures Recruiting NCT02783404 Phase 4 Amoxicillin;Amoxicillin-Potassium Clavulanate
14 Daptomycin as Adjunctive Therapy for Staphylococcus Aureus Bacteremia Recruiting NCT02972983 Phase 4 Daptomycin
15 Left Atrial Appendage CLOSURE in Patients With Atrial Fibrillation Compared to Medical Therapy Recruiting NCT03463317 Phase 4 Acetylsalicylic acid;Clopidogrel;Dabigatran;Rivaroxaban;Apixaban;Edoxaban;Phenprocoumon;Warfarin
16 Oritavancin for Staphylococcus Aureus Infections in Opioid Users Not yet recruiting NCT03761953 Phase 4 Oritavancin Injection
17 Impact of Antibiotic Treatment Following Implantation of Cardiac Electronic Device on Patient's Outcome Not yet recruiting NCT03148444 Phase 4 cefalexin 500 mg qid or roxithromycin 150 mg bid
18 Daptomycin as an Adjuvant Agent in the Treatment of Enterococcal Native Valve Endocarditis. Terminated NCT00401960 Phase 4 Daptomycin
19 Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE) Terminated NCT00638157 Phase 4 daptomycin;daptomycin and gentamicin
20 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
21 The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study Terminated NCT00164099 Phase 4 Synbiotic 2000
22 TRANscatheter or SurgIcal Aortic Valve ReplacemenT in All-Comers With Severe Aortic Valve Stenosis Withdrawn NCT02838199 Phase 4
23 Safety and Effectiveness Study of Perceval S Valve for Extended CE Mark Unknown status NCT01368666 Phase 2, Phase 3
24 Efficacy and Safety of Venus P-valve to Treat RVOT Stenosis With Pulmonary Regurgitation Unknown status NCT02071654 Phase 3
25 Minimally Invasive Transthoracic Device Closure in Perimembranous Ventricular Septal Defect Unknown status NCT02644330 Phase 2, Phase 3
26 Multi-center Trial of Percutaneous Pulmonary Valve Implantation With Venus-p Unknown status NCT02590679 Phase 2, Phase 3
27 Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus Completed NCT00093067 Phase 3 daptomycin
28 A Study of MK-3009 in Japanese Patients With Skin or Blood Stream Infections Caused by Methicillin-resistant Staphylococcus Aureus (MK-3009-002) Completed NCT00770341 Phase 3 Daptomycin 4 mg/kg;Comparator: vancomycin;Daptomycin 6 mg/kg
29 Population Pharmacokinetic (PK) Study of Multiple Doses of Cubicin® (Daptomycin) 10 mg/kg in Critical Care Patients Having Bacteremia, Endocarditis or Skin Soft Tissue Infections Due to Gram Positive Bacteria With Various Degrees of Renal Failure Completed NCT02142075 Phase 3 Daptomycin
30 Conservative Aortic Valve Surgery for Aortic Insufficiency and Aneurysms of the Aortic Root. CAVIAAR Completed NCT00478803 Phase 3
31 Early Antiretroviral Treatment and/or Early Isoniazid Prophylaxis Against Tuberculosis in HIV-infected Adults (ANRS 12136 TEMPRANO) Completed NCT00495651 Phase 3 Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis;Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis
32 Strategies Using Off-Patent Antibiotics for Methicillin Resistant S. Aureus "STOP MRSA" Completed NCT00729937 Phase 2, Phase 3 Cephalexin;Clindamycin;Trimethoprim-sulfamethoxazole
33 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus Recruiting NCT02701595 Phase 3 Amoxicillin
34 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus Recruiting NCT02701608 Phase 3 Levofloxacin;Rifampicin
35 Ceftobiprole in the Treatment of Patients With Staphylococcus Aureus Bacteremia Recruiting NCT03138733 Phase 3 Ceftobiprole medocaril;Daptomycin
36 Staphylococcus Aureus Bacteremia Antibiotic Treatment Options Recruiting NCT01792804 Phase 3 Trimethoprim-Sulfamethoxazole;Clindamycin;Linezolid;Flucloxacillin;Cloxacillin;Vancomycin;Daptomycin;Cefazolin
37 Transfer Factor Efficacy in the Management of Cirrhosis-associated Immune Dysfunction Recruiting NCT02837939 Phase 2, Phase 3 Human derived Transfer factor;Aqua pro injectione 4ml ampules for subcutaneous injection
38 STeroids to REduce Systemic Inflammation After Neonatal Heart Surgery Recruiting NCT03229538 Phase 3 Methylprednisolone;Isotonic saline
39 Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction. Recruiting NCT02836899 Phase 3 Nitric Oxide
40 A Phase 3 Telavancin Staphylococcus Aureus (S. Aureus) Bacteremia Trial Terminated NCT02208063 Phase 3 Telavancin;Vancomycin;Daptomycin;Synthetic penicillin;Cefazolin
41 Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections Terminated NCT00108433 Phase 3 Cefazolin IV;Linezolid IV;Vancomycin (IV)
42 Perioperative Ketorolac-lidocaine in the Patients With Valvular Heart Diseases During Cesarean Delivery Unknown status NCT01571791 Phase 2 Placebo;Ketorolac-Lidocaine
43 TranScatheter Aortic Valve RepLacement System US Feasibility Trial Unknown status NCT01932099 Phase 2
44 Bacteria Entering the Blood Stream From Tooth Extractions and Tooth Brushing Completed NCT00454285 Phase 2 Effect of Amoxicillin on bacteremia following a single-tooth extraction
45 Safety Evaluation of a Q-fever Vaccine, NDBR 105 Completed NCT00584454 Phase 2
46 Feasibility Study of a Percutaneous Mitral Valve Repair System. Completed NCT00209339 Phase 1, Phase 2
47 Assessment of Radiolabeled rhAnnexin V-128 in Infective Endocarditis Recruiting NCT02459613 Phase 1, Phase 2
48 Neonatal Vancomycin Trial Recruiting NCT02790996 Phase 2 Vancomycin
49 Surgical Implantation of TRAnscatheter vaLve in Native Mitral Annular Calcification (SITRAL) Study Recruiting NCT02830204 Phase 1, Phase 2
50 Evaluation of an Antibiotic Regimen Pharmacokinetic Applicable to Enterococcus Faecalis Infective Endocarditis Active, not recruiting NCT03681431 Phase 2 Ceftriaxone 4g/ 24h;Ceftriaxone 2g/ 12h

Search NIH Clinical Center for Endocarditis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: endocarditis

Genetic Tests for Endocarditis

Anatomical Context for Endocarditis

MalaCards organs/tissues related to Endocarditis:

41
Heart, Skin, Lung, Testes, Kidney, Liver, Brain

Publications for Endocarditis

Articles related to Endocarditis:

(show top 50) (show all 4020)
# Title Authors Year
1
Imaging the itis: endocarditis, myocarditis, and pericarditis. ( 30444758 )
2019
2
Human native endocarditis caused by Streptococcus canis-a case report. ( 30549135 )
2019
3
Pericardial effusion in infective endocarditis: The times they are a-changin'. ( 30301562 )
2019
4
Prosthetic valve endocarditis - A trouble or a challenge? ( 30389305 )
2019
5
Aspergillus endocarditis diagnosed by fungemia plus serum antigen testing. ( 30416954 )
2019
6
Fasciitis in a Boy with Kingella Kingae Infective Endocarditis. ( 29870103 )
2018
7
Candida catenulata Candidaemia and Possible Endocarditis in a Cirrhotic Patient Successfully De-escalated to Oral Fluconazole. ( 29956355 )
2018
8
Comparison of Dual I^-Lactam Therapy to Penicillin-Aminoglycoside Combination in Treatment of Enterococcus faecalis Infective Endocarditis. ( 29969596 )
2018
9
Efficacy and Safety of Fosfomycin Plus Imipenem vs. Vancomycin for Complicated Bacteremia and Endocarditis Due to Methicillin-Resistant Staphylococcus aureus: A Randomized Clinical Trial. ( 29408610 )
2018
10
Right-sided infective mural endocarditis complicated by septic pulmonary embolism and cardiac tamponade caused by MSSA. ( 29803298 )
2018
11
Sneddon syndrome and non-bacterial thrombotic endocarditis: a clinicopathological study. ( 29980854 )
2018
12
The diagnosis of microorganism involved in infective endocarditis (IE) by polymerase chain reaction (PCR) and real-time PCR: A systematic review. ( 29413230 )
2018
13
FISH and PNA FISH for the diagnosis of Q fever endocarditis and vascular infections. ( 29899006 )
2018
14
A challenging case of carbapenemase-producing Klebsiella pneumoniae septic thrombophlebitis and right mural endocarditis successfully treated with ceftazidime/avibactam. ( 29926399 )
2018
15
Case of infective endocarditis caused by implanted artificial hair pyoderma. ( 29923626 )
2018
16
Nonbacterial thrombotic endocarditis in a patient with primary antiphospholipid syndrome. ( 29977578 )
2018
17
Prognostic implications of a negative echocardiography in patients with infective endocarditis. ( 29409744 )
2018
18
Changes in the Association of Rising Infective Endocarditis With Mortality in People Who Inject Drugs. ( 29926083 )
2018
19
A broad-range PCR technique for the diagnosis of infective endocarditis. ( 29429763 )
2018
20
Nonbacterial Thrombotic Endocarditis Presenting with Leg Pain and a Left Atrial Mass Lesion. ( 29448257 )
2018
21
Endocarditis. ( 29971399 )
2018
22
Acquired ventricular septal defect due to infective endocarditis. ( 29440841 )
2018
23
Endocarditis after transcatheter aortic valve implantation: a current assessment. ( 29434627 )
2018
24
Primary Cardiac B-Non-Hodgkin Lymphoma Disguised as a Pacemaker Endocarditis. ( 29977733 )
2018
25
Hemolytic anemia due to native valve subacute endocarditis with<i>Actinomyces israelii</i>infection. ( 29445480 )
2018
26
A rare case of paradoxical embolism from tricuspid valve infective endocarditis and patent foramen ovale. ( 29372516 )
2018
27
Rare presentation of Candida albicans: infective endocarditis and a pulmonary coin lesion. ( 29513204 )
2018
28
Risk Stratification and Optimization of Cardiac Surgical Patients With Infective Endocarditis: Does It Matter? ( 29929896 )
2018
29
Bioprosthetic Versus Mechanical Valve Replacement for Infective Endocarditis: Focus on Recurrence Rates. ( 29452115 )
2018
30
Necrotizing Crescentic Glomerulonephritis Complicating Bivalvular Bacterial Endocarditis. ( 29942723 )
2018
31
Mitral valve repair versus replacement for infective endocarditis. What is better in the &amp;quot;real world&amp;quot;? ( 29958668 )
2018
32
Both-sided native valve infective endocarditis in a drug addict with incidental pneumoconiosis. ( 29704724 )
2018
33
Loeffler endocarditis as a rare cause of heart failure with preserved ejection fraction: A case report and review of literature. ( 29538200 )
2018
34
Probiotics and infective endocarditis in patients with hereditary hemorrhagic telangiectasia: a clinical case and a review of the literature. ( 29390976 )
2018
35
Emphysematous endocarditis caused by AmpC beta-lactamase-producing Escherichia coli: A case report. ( 29419663 )
2018
36
Bilateral septic arthritis of the sternoclavicular joint complicating infective endocarditis: a case report. ( 29973288 )
2018
37
Infective endocarditis in a patient with metastatic colorectal cancer. ( 29390605 )
2018
38
Outcomes of Reoperative Valve Replacement in Patients with Prosthetic Valve Endocarditis: A 20-Year Experience. ( 29430424 )
2018
39
Infective endocarditis associated with <i>Bartonella henselae</i>: A case series. ( 29942769 )
2018
40
Manuscript title: Cardiac and neurological involvement in Antiphospholipid syndrome: a case of a 47-year-old woman with nonbacterial thrombotic endocarditis and cognitive impairment. ( 29936322 )
2018
41
Endocarditis associated with vertebral osteomyelitis and septic arthritis of the axial skeleton. ( 29396671 )
2018
42
Marantic endocarditis: incidental infarcts leading to diagnosis of pancreatic cancer. ( 29895577 )
2018
43
Lessons learned from splenic infarcts with fever of unknown origin (FUO): culture-negative endocarditis (CNE) or malignancy? ( 29417312 )
2018
44
Infective Endocarditis Associated with Atrial Septal Defect in an Intravenous Drug Abuser: A Case Report. ( 29922523 )
2018
45
A pragmatic approach for mortality prediction after surgery in infective endocarditis: Optimizing and refining EuroSCORE. ( 29408350 )
2018
46
<i>Staphylococcus aureus</i> CC30 Lineage and Absence of <i>sed</i>,<i>j</i>,<i>r</i>-Harboring Plasmid Predict Embolism in Infective Endocarditis. ( 29938201 )
2018
47
Utility of cardiac computed tomography scanning in the diagnosis and pre-operative evaluation of patients with infective endocarditis. ( 29450741 )
2018
48
Marseille scoring system for empiric treatment of infective endocarditis. ( 29397446 )
2018
49
Endophthalmitis and Mycotic Aneurysm: The Only Clues to Underlying Endocarditis. ( 29849250 )
2018
50
Gemella bergeri infective endocarditis: a case report and brief review of literature. ( 29444729 )
2018

Variations for Endocarditis

Expression for Endocarditis

Search GEO for disease gene expression data for Endocarditis.

Pathways for Endocarditis

Pathways related to Endocarditis according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CEACAM8 CRP CXCL8 EPX FCGR2A IL10
2
Show member pathways
12.97 CXCL8 IL10 IL6 LBP TLR2 TNF
3
Show member pathways
12.84 CXCL8 EPX HSPD1 IL10 IL6 TNF
4
Show member pathways
12.29 CXCL8 IL6 TLR2 TNF
5
Show member pathways
12.29 ALB CRP F2 IL6 TNF
6
Show member pathways
12.26 CXCL8 IL6 LBP TNF
7
Show member pathways
12.23 CXCL8 IL6 TLR2 TNF
8
Show member pathways
12.22 FCGR2A IL10 TLR2 TNF
9
Show member pathways
12.17 CXCL8 IL6 TLR2 TNF
10
Show member pathways
12.13 CXCL8 IL6 LBP TLR2 TNF
11 12.1 CXCL8 HSPD1 IL10 IL6 TNF
12 12.04 ALB IL6 TNNI3 VCAM1
13
Show member pathways
12.03 IL10 IL6 TLR2 TNF
14 11.98 CXCL8 FCGR2A IL6 TNF
15 11.92 CEACAM8 FCGR2A IL10 IL6 TNF
16 11.88 CXCL8 IL6 TNF VCAM1
17 11.85 CXCL8 LBP TNF VCAM1
18
Show member pathways
11.83 F2 FCGR2A HSPD1 IL6 TLR2 TNF
19 11.82 CXCL8 IL6 TLR2 TNF
20
Show member pathways
11.78 CRP IL6 LBP
21 11.78 CXCL8 IL6 LBP
22 11.78 CXCL8 IL10 IL6 TLR2 TNF
23 11.75 FCGR2A HSPD1 IL10 IL6 LBP TLR2
24 11.73 CXCL8 IL10 IL6 TNF
25 11.7 IL10 IL6 TNF
26 11.69 FCGR2A IL10 IL6 TNF
27 11.69 CXCL8 IL10 IL6 LBP TNF VCAM1
28 11.63 CXCL8 IL6 TNF
29
Show member pathways
11.62 CXCL8 IL6 TNF VCAM1
30 11.47 CXCL8 IL10 IL6 TNF
31 11.46 CXCL8 HSPD1 IL6 TLR2 TNF
32 11.33 IL10 IL6 TNF
33 11.28 IL10 IL6 TNF VCAM1
34 11.23 IL10 IL6 TNF
35 11.16 CXCL8 IL10 IL6 TNF
36 10.95 CRP CXCL8 IL6 TNF
37 10.79 CXCL8 IL10 IL6 TLR2 TNF VCAM1

GO Terms for Endocarditis

Cellular components related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.96 ALB APOH CEACAM8 EPX F2 HSPD1
2 extracellular region GO:0005576 9.9 ALB APOH CRP CXCL8 EPX F2
3 cell surface GO:0009986 9.5 APOH CEACAM8 HSPD1 LBP TLR2 TNF
4 extracellular space GO:0005615 9.47 ALB APOH CEACAM8 CRP CXCL8 EPX

Biological processes related to Endocarditis according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.95 AQP9 CEACAM8 CXCL8 IL10 IL6 TLR2
2 defense response to bacterium GO:0042742 9.94 EPX IL10 LBP TNF
3 cellular protein metabolic process GO:0044267 9.92 ALB F2 IL6 SERPINC1
4 response to lipopolysaccharide GO:0032496 9.89 HSPD1 IL10 LBP TLR2 VCAM1
5 cellular response to lipopolysaccharide GO:0071222 9.88 CXCL8 IL10 IL6 LBP TNF
6 response to organic substance GO:0010033 9.86 AQP9 HSPD1 IL10 TNF
7 cytokine-mediated signaling pathway GO:0019221 9.85 CXCL8 IL10 IL6 LBP TNF VCAM1
8 response to glucocorticoid GO:0051384 9.83 HSPD1 IL10 IL6 TNF
9 positive regulation of inflammatory response GO:0050729 9.81 HSPD1 TLR2 TNF
10 lipopolysaccharide-mediated signaling pathway GO:0031663 9.76 LBP TLR2 TNF
11 positive regulation of interleukin-8 production GO:0032757 9.74 LBP TLR2 TNF
12 positive regulation of macrophage activation GO:0043032 9.71 HSPD1 IL10 LBP
13 negative regulation of growth of symbiont in host GO:0044130 9.69 IL10 LBP TNF
14 positive regulation of blood coagulation GO:0030194 9.65 APOH F2
15 cellular response to lipoteichoic acid GO:0071223 9.63 LBP TLR2
16 negative regulation of fibrinolysis GO:0051918 9.63 APOH F2
17 regulation of blood coagulation GO:0030193 9.63 APOH F2 SERPINC1
18 opsonization GO:0008228 9.62 CRP LBP
19 endothelial cell apoptotic process GO:0072577 9.61 IL10 TNF
20 response to molecule of bacterial origin GO:0002237 9.61 CXCL8 IL10 TLR2
21 negative regulation of cytokine secretion involved in immune response GO:0002740 9.6 IL10 TNF
22 positive regulation of neuroinflammatory response GO:0150078 9.59 IL6 TNF
23 receptor biosynthetic process GO:0032800 9.58 IL10 TNF
24 acute-phase response GO:0006953 9.56 CRP F2 IL6 LBP
25 defense response to Gram-positive bacterium GO:0050830 9.55 CRP IL6 LBP TLR2 TNF
26 negative regulation of lipid storage GO:0010888 9.5 CRP IL6 TNF
27 positive regulation of chemokine production GO:0032722 9.26 IL6 LBP TLR2 TNF
28 positive regulation of interleukin-6 production GO:0032755 9.02 HSPD1 IL6 LBP TLR2 TNF
29 inflammatory response GO:0006954 10.02 CRP CXCL8 IL10 IL6 TLR2 TNF
30 regulation of signaling receptor activity GO:0010469 10.01 CXCL8 F2 IL10 IL6 TNF

Molecular functions related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 ALB APOH CRP LACTB SERPINC1 TLR2
2 cytokine activity GO:0005125 9.46 CXCL8 IL10 IL6 TNF
3 lipopeptide binding GO:0071723 9.26 LBP TLR2
4 lipopolysaccharide binding GO:0001530 8.92 F2 HSPD1 LBP TLR2

Sources for Endocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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