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MCID: END033
MIFTS: 60

Endocarditis

Categories: Blood diseases, Cardiovascular diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Endocarditis

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MalaCards integrated aliases for Endocarditis:

Name: Endocarditis 12 77 56 44 45 15 64 17 74

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Respiratory diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:10314
ICD9CM 36 421.9
MeSH 45 D004696
SNOMED-CT 69 56819008 91357005
ICD10 34 I33.9
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Summaries for Endocarditis

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MedlinePlus : 44 Endocarditis, also called infective endocarditis (IE), is an inflammation of the inner lining of the heart. The most common type, bacterial endocarditis, occurs when germs enter your heart. These germs come through your bloodstream from another part of your body, often your mouth. Bacterial endocarditis can damage your heart valves. If untreated, it can be life-threatening. It is rare in healthy hearts. Risk factors include having An abnormal or damaged heart valve An artificial heart valve Congenital heart defects The signs and symptoms of IE can vary from person to person. They also can vary over time in the same person. Symptoms you might notice include fever, shortness of breath, fluid buildup in your arms or legs, tiny red spots on your skin, and weight loss. Your doctor will diagnose IE based on your risk factors, medical history, signs and symptoms, and lab and heart tests. Early treatment can help you avoid complications. Treatment usually involves high-dose antibiotics. If your heart valve is damaged, you may need surgery. If you're at risk for IE, brush and floss your teeth regularly, and have regular dental checkups. Germs from a gum infection can enter your bloodstream. If you are at high risk, your doctor might prescribe antibiotics before dental work and certain types of surgery. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Endocarditis is related to marantic endocarditis and infective endocarditis, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Endocarditis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Allograft rejection and Toll Comparative Pathway. The drugs Cefazolin and Dextrose USP and Vancomycin have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and liver, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Disease Ontology : 12 A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves.

PubMed Health : 64 About endocarditis: Endocarditis (EN-do-kar-DI-tis) is an infection of the inner lining of the heart chambers and valves. This lining is called the endocardium (en-do-KAR-de-um). The condition also is called infective endocarditis (IE).The term "endocarditis" also is used to describe an inflammation of the endocardium due to other conditions. This article only discusses endocarditis related to infection.IE occurs if bacteria, fungi, or other germs invade your bloodstream and attach to abnormal areas of your heart. The infection can damage your heart and cause serious and sometimes fatal complications.IE can develop quickly or slowly; it depends on what type of germ is causing it and whether you have an underlying heart problem. When IE develops quickly, it's called acute infective endocarditis. When it develops slowly, it's called subacute infective endocarditis.

Wikipedia : 77 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

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Related Diseases for Endocarditis

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Diseases in the Endocarditis family:

Subacute Bacterial Endocarditis

Diseases related to Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 792)
# Related Disease Score Top Affiliating Genes
1 marantic endocarditis 33.8 F2 PLAT SERPINC1
2 infective endocarditis 33.4 APOH AQP9 CRP F2 FCGR2A IL6
3 brucellosis 32.1 CRP CXCL8 IL10 IL6 TNF
4 q fever 31.6 IL10 IL6 TNF
5 pericarditis 31.1 CRP IL6 TNF
6 rheumatic fever 31.1 IL10 IL6 TNF
7 endomyocardial fibrosis 30.8 IL10 TNF
8 arthritis 30.7 CXCL8 IL10 IL6 TNF
9 spondylitis 30.6 CRP IL6 TNF
10 limb ischemia 30.6 IL6 TNF TNNI3
11 mycobacterium fortuitum 30.5 CXCL8 HSPD1 LACTB
12 pericardial effusion 30.5 CRP IL6 PIK3C2A
13 myocarditis 30.5 IL6 TNF TNNI3
14 adult-onset still's disease 30.5 CRP IL6 TNF
15 lupus erythematosus 30.5 APOH FCGR2A IL10 TNF
16 osteomyelitis 30.4 CXCL8 IL10 IL6 TNF
17 rheumatic heart disease 30.3 IL10 IL6 TNF VCAM1
18 intracranial embolism 30.3 F2 PLAT SERPINC1
19 melioidosis 30.3 IL10 IL6 TNF
20 heparin-induced thrombocytopenia 30.2 FCGR2A SERPINC1
21 dermatitis, atopic 30.2 CXCL8 EPX IL10 TNF
22 temporal arteritis 30.2 APOH CRP IL6 TNF
23 end stage renal failure 30.2 ALB CRP IL6 TNF
24 vasculitis 30.1 APOH CRP TNF VCAM1
25 fasciitis 30.1 CXCL8 IL6 TNF
26 drug reaction with eosinophilia and systemic symptoms 30.1 CRP TNF
27 autoimmune myocarditis 30.1 IL6 TNF
28 polyarteritis nodosa 30.1 APOH CRP IL6
29 human immunodeficiency virus infectious disease 30.1 IL10 IL6 TNF
30 purpura 30.1 APOH CRP F2 IL6 SERPINC1 TNF
31 thrombosis 30.1 APOH F2 PLAT SERPINC1
32 acquired immunodeficiency syndrome 30.1 ALB IL10 IL6 TNF
33 sudden sensorineural hearing loss 30.0 APOH F2 IL6
34 typhoid fever 30.0 ALB CRP F2 IL6 TNF
35 acute cystitis 30.0 ALB CRP CXCL8 IL6
36 colitis 30.0 CXCL8 IL10 IL6 TNF
37 budd-chiari syndrome 29.9 APOH F2 SERPINC1
38 scrub typhus 29.9 CRP IL10 TNF
39 branch retinal artery occlusion 29.9 APOH F2 SERPINC1
40 protein s deficiency 29.9 APOH F2 SERPINC1
41 echinococcosis 29.9 IL10 IL6 TNF
42 meningitis 29.9 ALB CRP CXCL8 FCGR2A IL10 IL6
43 complex regional pain syndrome 29.9 IL10 IL6 TNF
44 myeloma, multiple 29.9 ALB CRP CXCL8 IL6 TNF
45 cardiogenic shock 29.9 IL6 PIK3C2A PLAT TNF
46 disseminated intravascular coagulation 29.9 F2 PIK3C2A PLAT SERPINC1
47 patent foramen ovale 29.9 APOH F2 PLAT SERPINC1
48 pyelonephritis 29.9 ALB CRP CXCL8 IL10 IL6 TNF
49 pneumonia 29.8 CRP CXCL8 IL10 IL6 LACTB PIK3C2A
50 diabetes mellitus 29.8 ALB CRP HSPD1 IL6 PIK3C2A TNF

Graphical network of the top 20 diseases related to Endocarditis:



Diseases related to Endocarditis
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Symptoms & Phenotypes for Endocarditis

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UMLS symptoms related to Endocarditis:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Endocarditis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ALB CXCL8 FCGR2A HSPD1 PIK3C2A SERPINC1

MGI Mouse Phenotypes related to Endocarditis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 AQP9 EPX F2 FCGR2A IL10 IL6
2 cardiovascular system MP:0005385 10.02 CRP F2 IL10 IL6 PIK3C2A PLAT
3 homeostasis/metabolism MP:0005376 9.97 ALB APOH AQP9 CRP F2 IL10
4 immune system MP:0005387 9.77 AQP9 CRP EPX F2 FCGR2A IL10
5 mortality/aging MP:0010768 9.44 ALB APOH F2 FCGR2A HSPD1 IL10
Sources

Drugs & Therapeutics for Endocarditis

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PubMedHealth treatment related to Endocarditis: 64

Infective endocarditis (IE) is treated with antibiotics and sometimes with heart surgery.

FDA approved drugs:

# Drug Name Active Ingredient(s) 19 Company Approval Date
1
Cefazolin and Dextrose USP 19 CEFAZOLIN SODIUM B Braun Medical July 2000

Drugs for Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 239)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vancomycin Approved Phase 4,Phase 3,Phase 2,Not Applicable 1404-90-6 14969 441141
2
Rifampicin Approved Phase 4,Phase 3 13292-46-1 5381226 5458213
3
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
4
Daptomycin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 103060-53-3 16129629
5
Ceftaroline fosamil Approved, Investigational Phase 4,Phase 1 229016-73-3
6
Imipenem Approved Phase 4 64221-86-9, 74431-23-5 104838
7
Fosfomycin Approved Phase 4 23155-02-4 446987
8
Hexetidine Approved, Investigational Phase 4 141-94-6
9
Racepinephrine Approved Phase 4 329-65-7 838
10
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
11
Chlorhexidine Approved, Vet_approved Phase 4,Not Applicable 55-56-1 2713 9552079
12
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613
13
Warfarin Approved Phase 4,Not Applicable 81-81-2 54678486 6691
14
Cephalexin Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 15686-71-2 27447
15
Edoxaban Approved Phase 4,Not Applicable 480449-70-5
16
Clopidogrel Approved Phase 4,Not Applicable 120202-66-6, 113665-84-2 60606
17
Rivaroxaban Approved Phase 4,Not Applicable 366789-02-8
18
Aspirin Approved, Vet_approved Phase 4,Not Applicable 50-78-2 2244
19
Phenprocoumon Approved, Investigational Phase 4 435-97-2 54680692 9908
20
Apixaban Approved Phase 4,Not Applicable 503612-47-3 10182969
21
Linezolid Approved, Investigational Phase 4,Phase 3 165800-03-3 441401
22
Oritavancin Approved, Investigational Phase 4 171099-57-3 16129632
23
Serine Approved, Nutraceutical Phase 4,Not Applicable 56-45-1 5951
24
Dabigatran Investigational Phase 4,Not Applicable 211914-51-1
25 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Not Applicable
26 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 methicillin Phase 4,Phase 3,Phase 2
28 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable
30 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable
31 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
32 Anti-Arrhythmia Agents Phase 4,Phase 2
33 Anesthetics, Local Phase 4,Phase 2
34 Diuretics, Potassium Sparing Phase 4,Phase 2
35 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
36 Sodium Channel Blockers Phase 4,Phase 2
37 Cyclooxygenase Inhibitors Phase 4,Phase 2,Not Applicable
38 Analgesics Phase 4,Phase 2,Not Applicable
39 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Not Applicable
40 Analgesics, Non-Narcotic Phase 4,Phase 2,Not Applicable
41 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable
42 Antirheumatic Agents Phase 4,Phase 2,Not Applicable
43 beta-Lactams Phase 4
44 Lactams Phase 4
45 Dermatologic Agents Phase 4,Not Applicable
46 Respiratory System Agents Phase 4,Phase 3
47 Anti-Infective Agents, Local Phase 4,Not Applicable
48 Pharmaceutical Solutions Phase 4
49 Adrenergic Agents Phase 4,Not Applicable
50 Adrenergic alpha-Agonists Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 253)
# Name Status NCT ID Phase Drugs
1 Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study (ENDOVAL) Unknown status NCT00624091 Phase 4
2 Pharmacokinetics/ Pharmacodynamics (PK/PD) Study of Vancomycin Unknown status NCT02443064 Phase 4 Vancomycin
3 Duration of Antibiotic Therapy in Community - Acquired Pneumonia Unknown status NCT01492387 Phase 4
4 Partial Oral Treatment of Endocarditis Completed NCT01375257 Phase 4 Oral treatment with antibiotics for endocarditis;Guideline treatment with parenteral antibiotics
5 Early Surgery Versus Conventional Treatment in Infective Endocarditis Completed NCT00750373 Phase 4
6 Fosfomycin Plus Imipenem for Treatment of Infective Endocarditis Completed NCT00871104 Phase 4 Fosfomycin and imipenem;Vancomycin
7 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Completed NCT01920126 Phase 4 sodium bicarbonate;Saline
8 Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections Completed NCT00709358 Phase 4
9 Bacteraemia Secondary to Tooth Extraction: Chlorhexidine Prophylaxis Protocols Completed NCT02150031 Phase 4 0.2% Chlorhexidine;1% Chlorhexidine;1% Chlorhexidine;Lidocaine plus adrenaline
10 Bacteremia in Periodontal Patients Completed NCT02215473 Phase 4 Chlorhexidine gluconate mouth rinse
11 World-wide Randomized Antibiotic Envelope Infection Prevention Trial Completed NCT02277990 Phase 4
12 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Recruiting NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
13 Does Whole Blood Adsorber During CPB Reduce the Amount of Vasoactive Drugs Postoperatively in Endocarditis Patients Undergoing Valve Surgery? Recruiting NCT03945708 Phase 4
14 An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Dental Procedures Recruiting NCT02783404 Phase 4 Amoxicillin;Amoxicillin-Potassium Clavulanate
15 Daptomycin as Adjunctive Therapy for Staphylococcus Aureus Bacteremia Recruiting NCT02972983 Phase 4 Daptomycin
16 Left Atrial Appendage CLOSURE in Patients With Atrial Fibrillation Compared to Medical Therapy Recruiting NCT03463317 Phase 4 Acetylsalicylic acid;Clopidogrel;Dabigatran;Rivaroxaban;Apixaban;Edoxaban;Phenprocoumon;Warfarin
17 PWID; Longitudinal S Aureus Colonization Pattern and the Impact on Infection Frequency by Regular Showers With Chlorhexidine Active, not recruiting NCT03940729 Phase 4 Chlorhexidine Topical
18 Oritavancin for Staphylococcus Aureus Infections in Opioid Users Not yet recruiting NCT03761953 Phase 4 Oritavancin Injection
19 Impact of Antibiotic Treatment Following Implantation of Cardiac Electronic Device on Patient's Outcome Not yet recruiting NCT03148444 Phase 4 cefalexin 500 mg qid or roxithromycin 150 mg bid
20 Daptomycin as an Adjuvant Agent in the Treatment of Enterococcal Native Valve Endocarditis. Terminated NCT00401960 Phase 4 Daptomycin
21 Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE) Terminated NCT00638157 Phase 4 daptomycin;daptomycin and gentamicin
22 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
23 The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study Terminated NCT00164099 Phase 4 Synbiotic 2000
24 TRANscatheter or SurgIcal Aortic Valve ReplacemenT in All-Comers With Severe Aortic Valve Stenosis Withdrawn NCT02838199 Phase 4
25 Safety and Effectiveness Study of Perceval S Valve for Extended CE Mark Unknown status NCT01368666 Phase 2, Phase 3
26 Efficacy and Safety of Venus P-valve to Treat RVOT Stenosis With Pulmonary Regurgitation Unknown status NCT02071654 Phase 3
27 Minimally Invasive Transthoracic Device Closure in Perimembranous Ventricular Septal Defect Unknown status NCT02644330 Phase 2, Phase 3
28 Multi-center Trial of Percutaneous Pulmonary Valve Implantation With Venus-p Unknown status NCT02590679 Phase 2, Phase 3
29 Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus Completed NCT00093067 Phase 3 daptomycin
30 A Study of MK-3009 in Japanese Patients With Skin or Blood Stream Infections Caused by Methicillin-resistant Staphylococcus Aureus (MK-3009-002) Completed NCT00770341 Phase 3 Daptomycin 4 mg/kg;Comparator: vancomycin;Daptomycin 6 mg/kg
31 Population Pharmacokinetic (PK) Study of Multiple Doses of Cubicin® (Daptomycin) 10 mg/kg in Critical Care Patients Having Bacteremia, Endocarditis or Skin Soft Tissue Infections Due to Gram Positive Bacteria With Various Degrees of Renal Failure Completed NCT02142075 Phase 3 Daptomycin
32 Conservative Aortic Valve Surgery for Aortic Insufficiency and Aneurysms of the Aortic Root. CAVIAAR Completed NCT00478803 Phase 3
33 Early Antiretroviral Treatment and/or Early Isoniazid Prophylaxis Against Tuberculosis in HIV-infected Adults (ANRS 12136 TEMPRANO) Completed NCT00495651 Phase 3 Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis;Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis
34 Strategies Using Off-Patent Antibiotics for Methicillin Resistant S. Aureus "STOP MRSA" Completed NCT00729937 Phase 2, Phase 3 Cephalexin;Clindamycin;Trimethoprim-sulfamethoxazole
35 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus Recruiting NCT02701595 Phase 3 Amoxicillin
36 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus Recruiting NCT02701608 Phase 3 Levofloxacin;Rifampicin
37 Ceftobiprole in the Treatment of Patients With Staphylococcus Aureus Bacteremia Recruiting NCT03138733 Phase 3 Ceftobiprole medocaril;Daptomycin
38 Staphylococcus Aureus Bacteremia Antibiotic Treatment Options Recruiting NCT01792804 Phase 3 Trimethoprim-Sulfamethoxazole;Clindamycin;Linezolid;Flucloxacillin;Cloxacillin;Vancomycin;Daptomycin;Cefazolin
39 Transfer Factor Efficacy in the Management of Cirrhosis-associated Immune Dysfunction Recruiting NCT02837939 Phase 2, Phase 3 Human derived Transfer factor;Aqua pro injectione 4ml ampules for subcutaneous injection
40 STeroids to REduce Systemic Inflammation After Neonatal Heart Surgery Recruiting NCT03229538 Phase 3 Methylprednisolone;Isotonic saline
41 Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction. Recruiting NCT02836899 Phase 3 Nitric Oxide
42 A Phase 3 Telavancin Staphylococcus Aureus (S. Aureus) Bacteremia Trial Terminated NCT02208063 Phase 3 Telavancin;Vancomycin;Daptomycin;Synthetic penicillin;Cefazolin
43 Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections Terminated NCT00108433 Phase 3 Cefazolin IV;Linezolid IV;Vancomycin (IV)
44 Perioperative Ketorolac-lidocaine in the Patients With Valvular Heart Diseases During Cesarean Delivery Unknown status NCT01571791 Phase 2 Placebo;Ketorolac-Lidocaine
45 TranScatheter Aortic Valve RepLacement System US Feasibility Trial Unknown status NCT01932099 Phase 2
46 Safety, Efficacy and Pharmacokinetics of CF-301 vs. Placebo in Addition to Antibacterial Therapy for Treatment of S. Aureus Bacteremia Completed NCT03163446 Phase 2 Placebo
47 Bacteria Entering the Blood Stream From Tooth Extractions and Tooth Brushing Completed NCT00454285 Phase 2 Effect of Amoxicillin on bacteremia following a single-tooth extraction
48 Safety Evaluation of a Q-fever Vaccine, NDBR 105 Completed NCT00584454 Phase 2
49 Feasibility Study of a Percutaneous Mitral Valve Repair System. Completed NCT00209339 Phase 1, Phase 2
50 Assessment of Radiolabeled rhAnnexin V-128 in Infective Endocarditis Recruiting NCT02459613 Phase 1, Phase 2

Search NIH Clinical Center for Endocarditis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: endocarditis

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Genetic Tests for Endocarditis

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Anatomical Context for Endocarditis

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MalaCards organs/tissues related to Endocarditis:

42
Heart, Skin, Liver, Brain, Kidney, Testes, Colon
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Publications for Endocarditis

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Articles related to Endocarditis:

(show top 50) (show all 6690)
# Title Authors Year
1
Nursing Home Admission and Initiation of Domiciliary Care Following Infective Endocarditis. ( 30905692 )
2019
2
Management of endocarditis among persons who inject drugs: A narrative review of surgical and psychiatric approaches and controversies. ( 30908961 )
2019
3
Right-sided endocarditis from Staphylococcus lugdunensis in a patient with tetralogy of Fallot. ( 30915201 )
2019
4
Trends in Epidemiology: Analysis of Risk Factors and Outcomes of Infective Endocarditis: A Retrospective Study (2009-2015). ( 30915267 )
2019
5
Addressing limitations of partial oral treatment of left-sided infectious endocarditis (POET) criteria for prosthetic valve endocarditis: a note of caution. ( 30916328 )
2019
6
Epidemiological and clinical characteristics of Streptococcus tigurinus endocarditis. ( 30922322 )
2019
7
Late prosthetic valve endocarditis with Mycobacterium tuberculosis after the Bentall procedure. ( 30922382 )
2019
8
Variable Significance of Brain MRI Findings in Infective Endocarditis and Its Effect on Surgical Decisions. ( 30922693 )
2019
9
Escherichia coli endocarditis in an hemodialysis patient. ( 30926110 )
2019
10
Detection of pathogens from resected heart valves of patients with infective endocarditis by next-generation sequencing. ( 30926543 )
2019
11
Neurological Complications of Infective Endocarditis. ( 30927133 )
2019
12
Etiology, Risk Factors and Outcome of 1003 Cases of Infective Endocarditis from a 33-year National Survey in the Slovak Republic: An increasing proportion of elderly patients. ( 30927759 )
2019
13
Bordetella hinzii Endocarditis, A Clinical Case Not Previously Described. ( 30931262 )
2019
14
Bartonella henselae Endocarditis: An Usual Presentation of an Unusual Disease. ( 30931274 )
2019
15
Role of age and comorbidities in mortality of patients with infective endocarditis. ( 30904433 )
2019
16
Surgery-first treatment improves clinical results in infective endocarditis complicated with disseminated intravascular coagulation†. ( 30932157 )
2019
17
Does prolonged blood culture incubation improve microbiological diagnosis of HACEK and slow-growing bacteria infective endocarditis? ( 30937562 )
2019
18
Draft Genome Sequence of Campylobacter fetus subsp. fetus CITCf01, Isolated from a Patient with Subacute Bacterial Endocarditis. ( 30938325 )
2019
19
Non-HACEK Gram-negative bacillus endocarditis. ( 30940412 )
2019
20
Left-sided Pseudomonas Endocarditis with Disseminated Septic Emboli. ( 30943671 )
2019
21
Lactococcus garvieae, an unusual pathogen in infective endocarditis: case report and review of the literature. ( 30943906 )
2019
22
Native Aortic and Tricuspid Valve Endocarditis Complicated by Embolic ST Elevation Myocardial Infarction. ( 30944741 )
2019
23
Staphylococcus aureus endocarditis: distinct mechanisms of bacterial adhesion to damaged and inflamed heart valves. ( 30945735 )
2019
24
Prosthetic Valve Endocarditis Diagnosed by 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography. ( 30947842 )
2019
25
Long-Term Risk of Infective Endocarditis After Transcatheter Aortic Valve Replacement. ( 30947917 )
2019
26
A New Match Between Surgery and Transcatheter Aortic Valve Replacement: Fear the Endocarditis. ( 30947918 )
2019
27
Dynamic morphological changes in Libman-Sacks endocarditis under different anticoagulation regimens. ( 30948419 )
2019
28
High Morbidity and Mortality Among Patients With Sentinel Admission for Injection Drug Use-Related Infective Endocarditis. ( 30949535 )
2019
29
The role of 18F-FDG-PET/CT in the Diagnosis of left-sided Endocarditis: native vs. prosthetic valves endocarditis. ( 30949690 )
2019
30
Long-term outcome after tricuspid valvectomy in a neonate with Candida endocarditis: a case report. ( 30950361 )
2019
31
Acute ischemic stroke treated with mechanical thrombectomy and fungal endocarditis: A case report and systematic review of the literature. ( 30951768 )
2019
32
Acute kidney injury in infective endocarditis: A retrospective analysis. ( 30955847 )
2019
33
Cohort profile The ESC-EORP EURO-ENDO (European Infective Endocarditis) registry. ( 30957862 )
2019
34
Infective Endocarditis in the Intravenous Drug Use Population at a Tertiary Hospital in Melbourne, Australia. ( 30962062 )
2019
35
Commentary: Goals of surgical therapy in tricuspid valve endocarditis. ( 30901790 )
2019
36
Whipple's endocarditis diagnosed by thrombus analysis retrieved by successful mechanical thrombectomy. ( 30901568 )
2019
37
Group C Streptococcus dysgalactiae subsp.equisimilis (SDSE) Endocarditis with Endogenous Endophthalmitis and Aortic Root Abscess. ( 30899671 )
2019
38
Blocking a rash diagnosis: a rare case of infective endocarditis. ( 30898951 )
2019
39
Subacute Aerococcus urinae Infective Endocarditis With Mycotic Aneurysms in a Pediatric Patient: Case Report and Literature Review. ( 30892601 )
2019
40
ST-Elevation Myocardial Infarction Associated With Infective Endocarditis. ( 30890259 )
2019
41
Clinical hallmarks making diagnosis of infective endocarditis. ( 30887385 )
2019
42
Combination antifungal therapy for treatment of Candida parapsilosis prosthetic valve endocarditis and utility of T2Candida Panel®: A case series. ( 30976517 )
2019
43
The association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditis. ( 30977784 )
2019
44
Minimizing the gap between expectations and reality of mitral valve repair in infective endocarditis. ( 30979420 )
2019
45
Infective endocarditis guidance. ( 30979978 )
2019
46
Bartonella haenselae infective endocarditis following transcatheter edge-to-edge mitral valve repair: A case report. ( 30981216 )
2019
47
Impact of nuclear imaging on diagnosis and management of infective endocarditis. ( 30982414 )
2019
48
A case report of Guillain Barré syndrome revealing underlying infective endocarditis due to Cardiobacterium hominis. ( 30985649 )
2019
49
Cardiac Point-of-Care Ultrasound for the Diagnosis of Infective Endocarditis in a Patient with Non-Specific Rheumatologic Symptoms and Glomerulonephritis. ( 30996221 )
2019
50
Co-infection with bacterial and fungal endocarditis at scar tissue in an immunocompromised patient. ( 30996756 )
2019
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Variations for Endocarditis

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Expression for Endocarditis

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Search GEO for disease gene expression data for Endocarditis.
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Pathways for Endocarditis

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Pathways related to Endocarditis according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Allograft rejection 38 1
Show member pathways
 12.82 CXCL8 EPX HSPD1 IL10 IL6 TNF
2
Toll Comparative Pathway 65
Show member pathways
 12.24 CXCL8 IL6 LBP TNF
3
Selenium Micronutrient Network 1
Show member pathways
 12.18 ALB CRP F2 IL6 PLAT TNF
4
Bacterial infections in CF airways 23
Show member pathways
 12.14 CXCL8 IL6 LBP TNF
5
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.1 CXCL8 HSPD1 IL10 IL6 TNF
6
Tuberculosis 38
12.05 FCGR2A HSPD1 IL10 IL6 LBP TNF
7
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 66
12.02 ALB IL6 TNNI3 VCAM1
8
Spinal Cord Injury 1
11.96 CXCL8 FCGR2A IL6 TNF
9
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.9 CEACAM8 FCGR2A IL10 IL6 TNF
10
AGE-RAGE signaling pathway in diabetic complications 38
11.87 CXCL8 IL6 TNF VCAM1
11
NF-kappa B signaling pathway 38
11.85 CXCL8 LBP TNF VCAM1
12
Amoebiasis 38
11.84 CXCL8 IL10 IL6 TNF
13
Cytokine production by Th17 cells in CF (Mouse model) 23
Show member pathways
 11.8 CXCL8 IL6 LBP
14
Rheumatoid arthritis 38
11.78 CXCL8 IL6 TNF
15
Salmonella infection (KEGG) 38
11.75 CXCL8 IL6 LBP
16
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 11.73 F2 FCGR2A HSPD1 IL6 PLAT TNF
17
Pertussis 38
11.72 CXCL8 IL10 IL6 TNF
18
Dendritic Cells Developmental Lineage Pathway 66
11.68 IL10 IL6 TNF
19
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.68 FCGR2A IL10 IL6 TNF
20
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.61 CXCL8 IL6 TNF VCAM1
21
Lung fibrosis 1
11.6 CXCL8 IL6 TNF
22
Legionellosis 38
11.52 CXCL8 HSPD1 IL6 TNF
23
amb2 Integrin signaling 1
11.47 IL6 PLAT TNF
24
Interleukin-10 signaling 67
11.45 CXCL8 IL10 IL6 TNF
25
IL-10 Pathway 65
11.31 IL10 IL6 TNF
26
African trypanosomiasis 38
11.27 IL10 IL6 TNF VCAM1
27
Cytokines and Inflammatory Response 1
11.21 IL10 IL6 TNF
28
Interleukin-4 and 13 signaling 67
11.16 CXCL8 IL10 IL6 LBP TNF VCAM1
29
G-protein signaling_RhoB regulation pathway 23
11.15 CXCL8 IL10 IL6 TNF
30
Malaria 38
11.04 CXCL8 IL10 IL6 TNF VCAM1
31
Overview of nanoparticle effects 1
10.84 CRP CXCL8 IL6 TNF
Sources

GO Terms for Endocarditis

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Cellular components related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.9 ALB APOH CEACAM8 EPX F2 HSPD1
2 cell surface GO:0009986 9.8 APOH CEACAM8 HSPD1 LBP PLAT TNF
3 extracellular region GO:0005576 9.73 ALB APOH CRP CXCL8 EPX F2
4 extracellular space GO:0005615 9.5 ALB APOH CEACAM8 CRP CXCL8 EPX

Biological processes related to Endocarditis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.99 CXCL8 F2 IL10 IL6 TNF
2 inflammatory response GO:0006954 9.96 CRP CXCL8 IL10 IL6 TNF
3 defense response to bacterium GO:0042742 9.92 EPX IL10 LBP TNF
4 cellular protein metabolic process GO:0044267 9.9 ALB F2 IL6 SERPINC1
5 defense response to Gram-positive bacterium GO:0050830 9.81 CRP IL6 LBP TNF
6 cellular response to lipopolysaccharide GO:0071222 9.77 CXCL8 IL10 IL6 LBP TNF
7 response to lipopolysaccharide GO:0032496 9.72 IL10 LBP VCAM1
8 response to organic substance GO:0010033 9.67 AQP9 IL10 TNF
9 positive regulation of chemokine production GO:0032722 9.65 IL6 LBP TNF
10 positive regulation of blood coagulation GO:0030194 9.63 APOH F2
11 response to molecule of bacterial origin GO:0002237 9.63 CXCL8 IL10
12 positive regulation of macrophage activation GO:0043032 9.63 HSPD1 IL10 LBP
13 cytokine-mediated signaling pathway GO:0019221 9.63 CXCL8 IL10 IL6 LBP TNF VCAM1
14 plasminogen activation GO:0031639 9.62 APOH PLAT
15 negative regulation of fibrinolysis GO:0051918 9.61 APOH F2
16 opsonization GO:0008228 9.61 CRP LBP
17 response to glucocorticoid GO:0051384 9.61 IL10 IL6 TNF
18 endothelial cell apoptotic process GO:0072577 9.58 IL10 TNF
19 negative regulation of cytokine secretion involved in immune response GO:0002740 9.58 IL10 TNF
20 negative regulation of growth of symbiont in host GO:0044130 9.58 IL10 LBP TNF
21 positive regulation of neuroinflammatory response GO:0150078 9.57 IL6 TNF
22 positive regulation of interleukin-6 production GO:0032755 9.56 HSPD1 IL6 LBP TNF
23 receptor biosynthetic process GO:0032800 9.54 IL10 TNF
24 regulation of blood coagulation GO:0030193 9.5 APOH F2 SERPINC1
25 negative regulation of lipid storage GO:0010888 9.13 CRP IL6 TNF
26 acute-phase response GO:0006953 8.92 CRP F2 IL6 LBP
27 immune response GO:0006955 10 AQP9 CEACAM8 CXCL8 IL10 IL6 TNF

Molecular functions related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CXCL8 IL10 IL6 TNF
2 lipopolysaccharide binding GO:0001530 8.8 F2 HSPD1 LBP
Sources

Sources for Endocarditis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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