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MCID: END033
MIFTS: 58

Endocarditis

Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Endocarditis

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MalaCards integrated aliases for Endocarditis:

Name: Endocarditis 12 76 55 43 44 15 63 73

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:10314
ICD10 33 I33.9
ICD9CM 35 421.9
MeSH 44 D004696
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Summaries for Endocarditis

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MedlinePlus : 43 Endocarditis, also called infective endocarditis (IE), is an inflammation of the inner lining of the heart. The most common type, bacterial endocarditis, occurs when germs enter your heart. These germs come through your bloodstream from another part of your body, often your mouth. Bacterial endocarditis can damage your heart valves. If untreated, it can be life-threatening. It is rare in healthy hearts. Risk factors include having An abnormal or damaged heart valve An artificial heart valve Congenital heart defects The signs and symptoms of IE can vary from person to person. They also can vary over time in the same person. Symptoms you might notice include fever, shortness of breath, fluid buildup in your arms or legs, tiny red spots on your skin, and weight loss. Your doctor will diagnose IE based on your risk factors, medical history, signs and symptoms, and lab and heart tests. Early treatment can help you avoid complications. Treatment usually involves high-dose antibiotics. If your heart valve is damaged, you may need surgery. If you're at risk for IE, brush and floss your teeth regularly, and have regular dental checkups. Germs from a gum infection can enter your bloodstream. If you are at high risk, your doctor might prescribe antibiotics before dental work and certain types of surgery. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Endocarditis is related to brucellosis and infective endocarditis, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Endocarditis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Allograft rejection. The drugs Cefazolin and Dextrose USP and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and lung, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Disease Ontology : 12 A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves.

PubMed Health : 63 About endocarditis: Endocarditis (EN-do-kar-DI-tis) is an infection of the inner lining of the heart chambers and valves. This lining is called the endocardium (en-do-KAR-de-um). The condition also is called infective endocarditis (IE).The term "endocarditis" also is used to describe an inflammation of the endocardium due to other conditions. This article only discusses endocarditis related to infection.IE occurs if bacteria, fungi, or other germs invade your bloodstream and attach to abnormal areas of your heart. The infection can damage your heart and cause serious and sometimes fatal complications.IE can develop quickly or slowly; it depends on what type of germ is causing it and whether you have an underlying heart problem. When IE develops quickly, it's called acute infective endocarditis. When it develops slowly, it's called subacute infective endocarditis.

Wikipedia : 76 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

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Related Diseases for Endocarditis

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Diseases in the Endocarditis family:

Subacute Bacterial Endocarditis

Diseases related to Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 644)
# Related Disease Score Top Affiliating Genes
1 brucellosis 32.0 CRP CXCL8 IL10 IL6 TNF
2 infective endocarditis 31.3 APOH AQP9 CRP F2 FCGR2A IL6
3 pericarditis 31.1 CRP IL6 TNF
4 q fever 30.8 IL10 TLR2 TNF
5 mycobacterium fortuitum 30.8 CXCL8 HSPD1 LACTB
6 cellulitis 30.7 CRP LACTB TNF
7 temporal arteritis 30.6 APOH CRP IL6
8 cardiogenic shock 30.6 CRP IL6 PIK3C2A
9 microscopic polyangiitis 30.5 IL10 TNF
10 antiphospholipid syndrome 30.5 APOH F2 SERPINC1
11 ischemic heart disease 30.5 CRP F2 IL6 TNF
12 limb ischemia 30.4 IL6 TNF TNNI3
13 endomyocardial fibrosis 30.4 IL10 TNF
14 osteomyelitis 30.3 CXCL8 IL6 TNF
15 myocarditis 30.3 IL6 TNF TNNI3
16 spondylitis 30.3 CRP IL6 TNF
17 end stage renal failure 30.3 ALB CRP IL6 TNF
18 polyarteritis nodosa 30.2 APOH CRP IL6
19 pericardial effusion 30.2 CRP IL6 PIK3C2A
20 adult-onset still's disease 30.2 CRP FCGR2A IL6 TNF
21 disseminated intravascular coagulation 30.1 F2 PIK3C2A SERPINC1
22 thrombophlebitis 30.1 APOH F2 SERPINC1
23 rheumatic heart disease 30.1 IL10 IL6 TNF VCAM1
24 vasculitis 30.1 APOH CRP TNF VCAM1
25 streptococcal toxic-shock syndrome 30.1 CXCL8 IL6 TNF
26 protein s deficiency 30.0 APOH F2 SERPINC1
27 meconium aspiration syndrome 30.0 CXCL8 IL6 TNF
28 mycobacterium chelonae 30.0 CXCL8 TLR2
29 prostatitis 30.0 CXCL8 IL10 IL6 TNF
30 fasciitis 29.9 CXCL8 IL6 TNF
31 arthritis 29.9 CXCL8 IL10 IL6 TNF
32 purpura 29.9 APOH CRP F2 SERPINC1 TNF
33 stroke, ischemic 29.9 APOH CRP F2 SERPINC1
34 hypersplenism 29.9 ALB F2 SERPINC1
35 acquired immunodeficiency syndrome 29.9 ALB IL10 IL6 TNF
36 crohn's disease 29.9 CRP IL10 IL6 TNF
37 sneddon syndrome 29.9 APOH F2 SERPINC1
38 septic arthritis 29.9 CRP CXCL8 TLR2
39 compartment syndrome 29.9 ALB F2 PIK3C2A TNF
40 mycobacterium abscessus 29.8 CXCL8 TLR2 TNF
41 pneumoconiosis 29.8 CXCL8 IL6 TNF
42 peptic ulcer disease 29.8 CXCL8 IL10 TNF
43 thrombosis 29.8 APOH F2 SERPINC1
44 acute myocardial infarction 29.8 CRP PIK3C2A SERPINC1 TNNI3
45 lymphadenitis 29.7 CXCL8 IL10 TNF
46 heparin-induced thrombocytopenia 29.7 FCGR2A SERPINC1
47 severe hemophilia a 29.7 F2 FCGR2A IL10 TNF
48 haemophilus influenzae 29.7 CXCL8 TLR2 TNF
49 retinal artery occlusion 29.7 APOH F2 IL10 SERPINC1
50 monocytic leukemia 29.7 CXCL8 IL6 TNF

Graphical network of the top 20 diseases related to Endocarditis:



Diseases related to Endocarditis
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Symptoms & Phenotypes for Endocarditis

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UMLS symptoms related to Endocarditis:


angina pectoris, chest pain, edema

GenomeRNAi Phenotypes related to Endocarditis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ALB CXCL8 FCGR2A HSPD1 PIK3C2A SERPINC1

MGI Mouse Phenotypes related to Endocarditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 PIK3C2A EPX F2 SERPINC1 FCGR2A TLR2
2 cardiovascular system MP:0005385 10.07 CRP PIK3C2A F2 SERPINC1 TLR2 IL10
3 homeostasis/metabolism MP:0005376 10.07 PIK3C2A F2 SERPINC1 TLR2 IL10 ALB
4 immune system MP:0005387 9.97 PIK3C2A EPX F2 SERPINC1 FCGR2A TLR2
5 liver/biliary system MP:0005370 9.5 SERPINC1 TLR2 IL10 ALB IL6 LBP
6 mortality/aging MP:0010768 9.44 PIK3C2A F2 SERPINC1 FCGR2A HSPD1 TLR2
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Drugs & Therapeutics for Endocarditis

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PubMedHealth treatment related to Endocarditis: 63

Infective endocarditis (IE) is treated with antibiotics and sometimes with heart surgery.

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Cefazolin and Dextrose USP 18 CEFAZOLIN SODIUM B Braun Medical July 2000

Drugs for Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 215)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
2
Rifampicin Approved Phase 4,Phase 3 13292-46-1 5458213 5381226
3
Daptomycin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 103060-53-3 16129629
4
Vancomycin Approved Phase 4,Phase 3,Phase 2 1404-90-6 441141 14969
5
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
6
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613
7
Cephalexin Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 15686-71-2 27447
8
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
9
Fosfomycin Approved Phase 4 23155-02-4 446987
10
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
11
Hexetidine Approved, Investigational Phase 4 141-94-6
12
Racepinephrine Approved Phase 4 329-65-7 838
13
Linezolid Approved, Investigational Phase 4,Phase 3 165800-03-3 441401
14 methicillin Phase 4,Phase 3,Phase 2
15 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
16 Sodium Channel Blockers Phase 4,Phase 2
17 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable
18 Anesthetics, Local Phase 4,Phase 2
19 Diuretics, Potassium Sparing Phase 4,Phase 2
20 Anti-Arrhythmia Agents Phase 4,Phase 2
21 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
22 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
23 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Not Applicable
24 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
25 Lactams Phase 4
26 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable
27 beta-Lactams Phase 4
28 Chlorhexidine gluconate Phase 4
29 Respiratory System Agents Phase 4,Phase 3
30 Adrenergic Agents Phase 4,Not Applicable
31 Adrenergic Agonists Phase 4,Not Applicable
32 Adrenergic alpha-Agonists Phase 4,Not Applicable
33 Adrenergic beta-Agonists Phase 4
34 Mydriatics Phase 4
35 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable
36 Dermatologic Agents Phase 4
37 Disinfectants Phase 4
38 Vasoconstrictor Agents Phase 4
39 Anti-Asthmatic Agents Phase 4,Phase 3
40 Epinephryl borate Phase 4
41 Pharmaceutical Solutions Phase 4
42 Anti-Infective Agents, Local Phase 4,Not Applicable
43 Autonomic Agents Phase 4,Phase 3
44 Bronchodilator Agents Phase 4,Phase 3
45 Clavulanic Acid Phase 4
46 Amoxicillin-Potassium Clavulanate Combination Phase 4
47 Gentamicins Phase 4,Phase 3
48 beta-Lactamase Inhibitors Phase 4
49
Sulfamethoxazole Approved Phase 2, Phase 3,Phase 3 723-46-6 5329
50
Isoniazid Approved, Investigational Phase 3 54-85-3 3767

Interventional clinical trials:

(show top 50) (show all 208)
# Name Status NCT ID Phase Drugs
1 Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study (ENDOVAL) Unknown status NCT00624091 Phase 4
2 Pharmacokinetics/ Pharmacodynamics (PK/PD) Study of Vancomycin Unknown status NCT02443064 Phase 4 Vancomycin
3 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Unknown status NCT01920126 Phase 4 sodium bicarbonate;Saline
4 Duration of Antibiotic Therapy in Community - Acquired Pneumonia Unknown status NCT01492387 Phase 4
5 Partial Oral Treatment of Endocarditis Completed NCT01375257 Phase 4 Oral treatment with antibiotics for endocarditis;Guideline treatment with parenteral antibiotics
6 Early Surgery Versus Conventional Treatment in Infective Endocarditis Completed NCT00750373 Phase 4
7 Fosfomycin Plus Imipenem for Treatment of Infective Endocarditis Completed NCT00871104 Phase 4 Fosfomycin and imipenem;Vancomycin
8 Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections Completed NCT00709358 Phase 4
9 Bacteraemia Secondary to Tooth Extraction: Chlorhexidine Prophylaxis Protocols Completed NCT02150031 Phase 4 0.2% Chlorhexidine;1% Chlorhexidine;1% Chlorhexidine;Lidocaine plus adrenaline
10 Bacteremia in Periodontal Patients Completed NCT02215473 Phase 4 Chlorhexidine gluconate mouth rinse
11 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Recruiting NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
12 An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Dental Procedures Recruiting NCT02783404 Phase 4 Amoxicillin;Amoxicillin-Potassium Clavulanate
13 Daptomycin as Adjunctive Therapy for Staphylococcus Aureus Bacteremia Recruiting NCT02972983 Phase 4 Daptomycin
14 Left Atrial Appendage CLOSURE in Patients With Atrial Fibrillation Compared to Medical Therapy Recruiting NCT03463317 Phase 4 Acetylsalicylic acid;Clopidogrel;Dabigatran;Rivaroxaban;Apixaban;Edoxaban;Phenprocoumon;Warfarin
15 World-wide Randomized Antibiotic Envelope Infection Prevention Trial Active, not recruiting NCT02277990 Phase 4
16 Impact of Antibiotic Treatment Following Implantation of Cardiac Electronic Device on Patient's Outcome Not yet recruiting NCT03148444 Phase 4 cefalexin 500 mg qid or roxithromycin 150 mg bid
17 Daptomycin as an Adjuvant Agent in the Treatment of Enterococcal Native Valve Endocarditis. Terminated NCT00401960 Phase 4 Daptomycin
18 Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE) Terminated NCT00638157 Phase 4 daptomycin;daptomycin and gentamicin
19 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
20 The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study Terminated NCT00164099 Phase 4 Synbiotic 2000
21 TRANscatheter or SurgIcal Aortic Valve ReplacemenT in All-Comers With Severe Aortic Valve Stenosis Withdrawn NCT02838199 Phase 4
22 Efficacy and Safety of Venus P-valve to Treat RVOT Stenosis With Pulmonary Regurgitation Unknown status NCT02071654 Phase 3
23 Minimally Invasive Transthoracic Device Closure in Perimembranous Ventricular Septal Defect Unknown status NCT02644330 Phase 2, Phase 3
24 Multi-center Trial of Percutaneous Pulmonary Valve Implantation With Venus-p Unknown status NCT02590679 Phase 2, Phase 3
25 Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus Completed NCT00093067 Phase 3 daptomycin
26 A Study of MK-3009 in Japanese Patients With Skin or Blood Stream Infections Caused by Methicillin-resistant Staphylococcus Aureus (MK-3009-002) Completed NCT00770341 Phase 3 Daptomycin 4 mg/kg;Comparator: vancomycin;Daptomycin 6 mg/kg
27 Population Pharmacokinetic (PK) Study of Multiple Doses of Cubicin® (Daptomycin) 10 mg/kg in Critical Care Patients Having Bacteremia, Endocarditis or Skin Soft Tissue Infections Due to Gram Positive Bacteria With Various Degrees of Renal Failure Completed NCT02142075 Phase 3 Daptomycin
28 Conservative Aortic Valve Surgery for Aortic Insufficiency and Aneurysms of the Aortic Root. CAVIAAR Completed NCT00478803 Phase 3
29 Early Antiretroviral Treatment and/or Early Isoniazid Prophylaxis Against Tuberculosis in HIV-infected Adults (ANRS 12136 TEMPRANO) Completed NCT00495651 Phase 3 Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis;Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis
30 Strategies Using Off-Patent Antibiotics for Methicillin Resistant S. Aureus "STOP MRSA" Completed NCT00729937 Phase 2, Phase 3 Cephalexin;Clindamycin;Trimethoprim-sulfamethoxazole
31 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus Recruiting NCT02701595 Phase 3 Amoxicillin
32 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus Recruiting NCT02701608 Phase 3 Levofloxacin;Rifampicin
33 Staphylococcus Aureus Bacteremia Antibiotic Treatment Options Recruiting NCT01792804 Phase 3 Trimethoprim-Sulfamethoxazole;Clindamycin;Linezolid;Flucloxacillin;Cloxacillin;Vancomycin;Daptomycin;Cefazolin
34 Transfer Factor Efficacy in the Management of Cirrhosis-associated Immune Dysfunction Recruiting NCT02837939 Phase 2, Phase 3 Human derived Transfer factor;Aqua pro injectione 4ml ampules for subcutaneous injection
35 STeroids to REduce Systemic Inflammation After Neonatal Heart Surgery Recruiting NCT03229538 Phase 3 Methylprednisolone;Isotonic saline
36 Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction. Recruiting NCT02836899 Phase 3 Nitric Oxide
37 A Phase 3 Telavancin Staphylococcus Aureus (S. Aureus) Bacteremia Trial Active, not recruiting NCT02208063 Phase 3 Telavancin;Vancomycin;Daptomycin;Synthetic penicillin;Cefazolin
38 Safety and Effectiveness Study of Perceval S Valve for Extended CE Mark Active, not recruiting NCT01368666 Phase 2, Phase 3
39 Ceftobiprole in the Treatment of Patients With Staphylococcus Aureus Bacteremia Not yet recruiting NCT03138733 Phase 3 Ceftobiprole medocaril;Daptomycin
40 Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections Terminated NCT00108433 Phase 3 Cefazolin IV;Linezolid IV;Vancomycin (IV)
41 Perioperative Ketorolac-lidocaine in the Patients With Valvular Heart Diseases During Cesarean Delivery Unknown status NCT01571791 Phase 2 Placebo;Ketorolac-Lidocaine
42 Bacteria Entering the Blood Stream From Tooth Extractions and Tooth Brushing Completed NCT00454285 Phase 2 Effect of Amoxicillin on bacteremia following a single-tooth extraction
43 Safety Evaluation of a Q-fever Vaccine, NDBR 105 Completed NCT00584454 Phase 2
44 Feasibility Study of a Percutaneous Mitral Valve Repair System. Completed NCT00209339 Phase 1, Phase 2
45 Assessment of Radiolabeled rhAnnexin V-128 in Infective Endocarditis Recruiting NCT02459613 Phase 1, Phase 2
46 Safety, Efficacy and Pharmacokinetics of CF-301 vs. Placebo in Addition to Antibacterial Therapy for Treatment of S. Aureus Bacteremia Recruiting NCT03163446 Phase 2 Placebo
47 Neonatal Vancomycin Trial Recruiting NCT02790996 Phase 2 Vancomycin
48 Surgical Implantation of TRAnscatheter vaLve in Native Mitral Annular Calcification (SITRAL) Study Recruiting NCT02830204 Phase 1, Phase 2
49 TranScatheter Aortic Valve RepLacement System US Feasibility Trial Active, not recruiting NCT01932099 Phase 2
50 Bioprosthetic or Native Aortic Scallop Intentional Laceration to Prevent Iatrogenic Coronary Artery Obstruction (BASILICA) Prospective Investigation Not yet recruiting NCT03381989 Phase 1, Phase 2

Search NIH Clinical Center for Endocarditis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: endocarditis

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Genetic Tests for Endocarditis

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Anatomical Context for Endocarditis

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MalaCards organs/tissues related to Endocarditis:

41
Heart, Skin, Lung, Testes, Brain, Endothelial, Liver
Sources

Publications for Endocarditis

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Articles related to Endocarditis:

(show top 50) (show all 2268)
# Title Authors Year
1
Fasciitis in a Boy with Kingella Kingae Infective Endocarditis. ( 29870103 )
2018
2
Candida catenulata Candidaemia and Possible Endocarditis in a Cirrhotic Patient Successfully De-escalated to Oral Fluconazole. ( 29956355 )
2018
3
Comparison of Dual I^-Lactam Therapy to Penicillin-Aminoglycoside Combination in Treatment of Enterococcus faecalis Infective Endocarditis. ( 29969596 )
2018
4
Efficacy and Safety of Fosfomycin Plus Imipenem vs. Vancomycin for Complicated Bacteremia and Endocarditis Due to Methicillin-Resistant Staphylococcus aureus: A Randomized Clinical Trial. ( 29408610 )
2018
5
Right-sided infective mural endocarditis complicated by septic pulmonary embolism and cardiac tamponade caused by MSSA. ( 29803298 )
2018
6
Sneddon syndrome and non-bacterial thrombotic endocarditis: a clinicopathological study. ( 29980854 )
2018
7
The diagnosis of microorganism involved in infective endocarditis (IE) by polymerase chain reaction (PCR) and real-time PCR: A systematic review. ( 29413230 )
2018
8
FISH and PNA FISH for the diagnosis of Q fever endocarditis and vascular infections. ( 29899006 )
2018
9
A challenging case of carbapenemase-producing Klebsiella pneumoniae septic thrombophlebitis and right mural endocarditis successfully treated with ceftazidime/avibactam. ( 29926399 )
2018
10
Case of infective endocarditis caused by implanted artificial hair pyoderma. ( 29923626 )
2018
11
Nonbacterial thrombotic endocarditis in a patient with primary antiphospholipid syndrome. ( 29977578 )
2018
12
Prognostic implications of a negative echocardiography in patients with infective endocarditis. ( 29409744 )
2018
13
Changes in the Association of Rising Infective Endocarditis With Mortality in People Who Inject Drugs. ( 29926083 )
2018
14
A broad-range PCR technique for the diagnosis of infective endocarditis. ( 29429763 )
2018
15
Nonbacterial Thrombotic Endocarditis Presenting with Leg Pain and a Left Atrial Mass Lesion. ( 29448257 )
2018
16
Endocarditis. ( 29971399 )
2018
17
Acquired ventricular septal defect due to infective endocarditis. ( 29440841 )
2018
18
Endocarditis after transcatheter aortic valve implantation: a current assessment. ( 29434627 )
2018
19
Primary Cardiac B-Non-Hodgkin Lymphoma Disguised as a Pacemaker Endocarditis. ( 29977733 )
2018
20
Hemolytic anemia due to native valve subacute endocarditis with<i>Actinomyces israelii</i>infection. ( 29445480 )
2018
21
A rare case of paradoxical embolism from tricuspid valve infective endocarditis and patent foramen ovale. ( 29372516 )
2018
22
Rare presentation of Candida albicans: infective endocarditis and a pulmonary coin lesion. ( 29513204 )
2018
23
Risk Stratification and Optimization of Cardiac Surgical Patients With Infective Endocarditis: Does It Matter? ( 29929896 )
2018
24
Bioprosthetic Versus Mechanical Valve Replacement for Infective Endocarditis: Focus on Recurrence Rates. ( 29452115 )
2018
25
Necrotizing Crescentic Glomerulonephritis Complicating Bivalvular Bacterial Endocarditis. ( 29942723 )
2018
26
Mitral valve repair versus replacement for infective endocarditis. What is better in the &amp;quot;real world&amp;quot;? ( 29958668 )
2018
27
Both-sided native valve infective endocarditis in a drug addict with incidental pneumoconiosis. ( 29704724 )
2018
28
Loeffler endocarditis as a rare cause of heart failure with preserved ejection fraction: A case report and review of literature. ( 29538200 )
2018
29
Probiotics and infective endocarditis in patients with hereditary hemorrhagic telangiectasia: a clinical case and a review of the literature. ( 29390976 )
2018
30
Emphysematous endocarditis caused by AmpC beta-lactamase-producing Escherichia coli: A case report. ( 29419663 )
2018
31
Bilateral septic arthritis of the sternoclavicular joint complicating infective endocarditis: a case report. ( 29973288 )
2018
32
Infective endocarditis in a patient with metastatic colorectal cancer. ( 29390605 )
2018
33
Outcomes of Reoperative Valve Replacement in Patients with Prosthetic Valve Endocarditis: A 20-Year Experience. ( 29430424 )
2018
34
Infective endocarditis associated with <i>Bartonella henselae</i>: A case series. ( 29942769 )
2018
35
Manuscript title: Cardiac and neurological involvement in Antiphospholipid syndrome: a case of a 47-year-old woman with nonbacterial thrombotic endocarditis and cognitive impairment. ( 29936322 )
2018
36
Endocarditis associated with vertebral osteomyelitis and septic arthritis of the axial skeleton. ( 29396671 )
2018
37
Marantic endocarditis: incidental infarcts leading to diagnosis of pancreatic cancer. ( 29895577 )
2018
38
Lessons learned from splenic infarcts with fever of unknown origin (FUO): culture-negative endocarditis (CNE) or malignancy? ( 29417312 )
2018
39
Infective Endocarditis Associated with Atrial Septal Defect in an Intravenous Drug Abuser: A Case Report. ( 29922523 )
2018
40
A pragmatic approach for mortality prediction after surgery in infective endocarditis: Optimizing and refining EuroSCORE. ( 29408350 )
2018
41
<i>Staphylococcus aureus</i> CC30 Lineage and Absence of <i>sed</i>,<i>j</i>,<i>r</i>-Harboring Plasmid Predict Embolism in Infective Endocarditis. ( 29938201 )
2018
42
Utility of cardiac computed tomography scanning in the diagnosis and pre-operative evaluation of patients with infective endocarditis. ( 29450741 )
2018
43
Marseille scoring system for empiric treatment of infective endocarditis. ( 29397446 )
2018
44
Endophthalmitis and Mycotic Aneurysm: The Only Clues to Underlying Endocarditis. ( 29849250 )
2018
45
Gemella bergeri infective endocarditis: a case report and brief review of literature. ( 29444729 )
2018
46
Problems in anticoagulation of a patient with antibiotic treatment for endocarditis: interaction of rifampicin and vitamin K antagonists. ( 29440136 )
2018
47
Pulmonary artery intravascular abscess: A rare complication of incomplete infective endocarditis treatment in the setting of injection drug use. ( 29942758 )
2018
48
Outcome of Infective Endocarditis in the Current Era: Early Predictors of Poor Prognosis. ( 29382606 )
2018
49
External validation of the new predictive model for early mortality after surgical treatment of infective endocarditis: Analysis of the reliability of EndoSCORE. ( 29934231 )
2018
50
A Case of Anterior Spinal Artery Syndrome Caused by <i>Streptococcus mitis</i> Endocarditis. ( 29560019 )
2018
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Variations for Endocarditis

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Expression for Endocarditis

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Search GEO for disease gene expression data for Endocarditis.
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Pathways for Endocarditis

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Pathways related to Endocarditis according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.96 CXCL8 IL10 IL6 LBP TLR2 TNF
2
Allograft rejection 1 37
Show member pathways
 12.82 CXCL8 EPX HSPD1 IL10 IL6 TNF
3
Th17 cell differentiation 37
Show member pathways
 12.38 IL10 IL6 TLR2 TNF
4
IL-17 Family Signaling Pathways 65
Show member pathways
 12.28 CXCL8 IL6 TLR2 TNF
5
Folate Metabolism 1
Show member pathways
 12.27 ALB CRP F2 IL6 TNF
6
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.22 CXCL8 IL6 TLR2 TNF
7
Toll Comparative Pathway 64
Show member pathways
 12.21 CXCL8 IL6 LBP TNF
8
Th1 Differentiation Pathway 65
Show member pathways
 12.2 IL10 IL6 TLR2 TNF
9
Toxoplasmosis 37
Show member pathways
 12.2 FCGR2A IL10 TLR2 TNF
10
IL-1 Family Signaling Pathways 65
Show member pathways
 12.16 CXCL8 IL6 TLR2 TNF
11
Bacterial infections in CF airways 22
Show member pathways
 12.11 CXCL8 IL6 LBP TLR2 TNF
12
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.09 CXCL8 HSPD1 IL10 IL6 TNF
13
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 65
12.02 ALB IL6 TNNI3 VCAM1
14
Spinal Cord Injury 1
11.96 CXCL8 FCGR2A IL6 TNF
15
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.9 CEACAM8 FCGR2A IL10 IL6 TNF
16
AGE-RAGE signaling pathway in diabetic complications 37
11.86 CXCL8 IL6 TNF VCAM1
17
NF-kappa B signaling pathway 37
11.84 CXCL8 LBP TNF VCAM1
18
Rheumatoid arthritis 37
11.8 CXCL8 IL6 TLR2 TNF
19
IL6-mediated signaling events 1
Show member pathways
 11.77 CRP IL6 LBP
20
Salmonella infection (KEGG) 37
11.77 CXCL8 IL6 LBP
21
Amoebiasis 37
11.75 CXCL8 IL10 IL6 TLR2 TNF
22
Tuberculosis 37
11.75 FCGR2A HSPD1 IL10 IL6 LBP TLR2
23
Pertussis 37
11.71 CXCL8 IL10 IL6 TNF
24
Dendritic Cells Developmental Lineage Pathway 65
11.7 IL10 IL6 TNF
25
Interleukin-4 and 13 signaling 66
11.69 CXCL8 IL10 IL6 LBP TNF VCAM1
26
Lung fibrosis 1
11.62 CXCL8 IL6 TNF
27
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.61 CXCL8 IL6 TNF VCAM1
28
Interleukin-10 signaling 66
11.45 CXCL8 IL10 IL6 TNF
29
Legionellosis 37
11.4 CXCL8 HSPD1 IL6 TLR2 TNF
30
IL-10 Pathway 64
11.31 IL10 IL6 TNF
31
African trypanosomiasis 37
11.25 IL10 IL6 TNF VCAM1
32
Cytokines and Inflammatory Response 1
11.23 IL10 IL6 TNF
33
Overview of nanoparticle effects 1
10.9 CRP CXCL8 IL6 TNF
34
Malaria 37
10.79 CXCL8 IL10 IL6 TLR2 TNF VCAM1
Sources

GO Terms for Endocarditis

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Cellular components related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 ALB APOH CRP CXCL8 EPX F2
2 cell surface GO:0009986 9.73 APOH HSPD1 LBP TLR2 TNF VCAM1
3 extracellular exosome GO:0070062 9.73 ALB APOH CEACAM8 CRP EPX F2
4 extracellular space GO:0005615 9.47 ALB APOH CEACAM8 CRP CXCL8 EPX

Biological processes related to Endocarditis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.95 AQP9 CEACAM8 CXCL8 IL10 IL6 TLR2
2 defense response to bacterium GO:0042742 9.92 EPX IL10 LBP TNF
3 response to lipopolysaccharide GO:0032496 9.92 CXCL8 IL10 LBP TLR2 VCAM1
4 cellular protein metabolic process GO:0044267 9.91 ALB F2 IL6 SERPINC1
5 cytokine-mediated signaling pathway GO:0019221 9.91 CXCL8 IL10 IL6 LBP TNF VCAM1
6 response to glucocorticoid GO:0051384 9.77 IL10 IL6 TNF
7 cellular response to lipopolysaccharide GO:0071222 9.77 CXCL8 IL10 IL6 LBP TNF
8 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 LBP TLR2 TNF
9 positive regulation of interleukin-8 production GO:0032757 9.72 LBP TLR2 TNF
10 positive regulation of macrophage activation GO:0043032 9.69 HSPD1 IL10 LBP
11 negative regulation of growth of symbiont in host GO:0044130 9.67 IL10 LBP TNF
12 regulation of blood coagulation GO:0030193 9.65 APOH F2 SERPINC1
13 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL10 TNF
14 cellular response to lipoteichoic acid GO:0071223 9.63 LBP TLR2
15 response to molecule of bacterial origin GO:0002237 9.63 CXCL8 IL10 TLR2
16 negative regulation of fibrinolysis GO:0051918 9.62 APOH F2
17 opsonization GO:0008228 9.61 CRP LBP
18 endothelial cell apoptotic process GO:0072577 9.58 IL10 TNF
19 negative regulation of cytokine secretion involved in immune response GO:0002740 9.58 IL10 TNF
20 receptor biosynthetic process GO:0032800 9.57 IL10 TNF
21 acute-phase response GO:0006953 9.56 CRP F2 IL6 LBP
22 defense response to Gram-positive bacterium GO:0050830 9.55 CRP IL6 LBP TLR2 TNF
23 negative regulation of lipid storage GO:0010888 9.5 CRP IL6 TNF
24 positive regulation of chemokine production GO:0032722 9.26 IL6 LBP TLR2 TNF
25 positive regulation of interleukin-6 production GO:0032755 9.02 HSPD1 IL6 LBP TLR2 TNF
26 inflammatory response GO:0006954 10.01 CRP CXCL8 IL10 IL6 TLR2 TNF
27 regulation of signaling receptor activity GO:0010469 10 CXCL8 F2 IL10 IL6 TNF

Molecular functions related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CXCL8 IL10 IL6 TNF
2 lipopeptide binding GO:0071723 9.16 LBP TLR2
3 lipopolysaccharide binding GO:0001530 8.92 F2 HSPD1 LBP TLR2
Sources

Sources for Endocarditis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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