MCID: END033
MIFTS: 57

Endocarditis

Categories: Blood diseases, Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Endocarditis

MalaCards integrated aliases for Endocarditis:

Name: Endocarditis 12 74 54 42 43 15 62 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10314
ICD9CM 34 421.9
MeSH 43 D004696
SNOMED-CT 67 56819008 91357005
ICD10 32 I33.9
UMLS 71 C0014118 C0375268

Summaries for Endocarditis

MedlinePlus : 42 Endocarditis, also called infective endocarditis (IE), is an inflammation of the inner lining of the heart. The most common type, bacterial endocarditis, occurs when germs enter your heart. These germs come through your bloodstream from another part of your body, often your mouth. Bacterial endocarditis can damage your heart valves. If untreated, it can be life-threatening. It is rare in healthy hearts. Risk factors include having An abnormal or damaged heart valve An artificial heart valve Congenital heart defects The signs and symptoms of IE can vary from person to person. They also can vary over time in the same person. Symptoms you might notice include fever, shortness of breath, fluid buildup in your arms or legs, tiny red spots on your skin, and weight loss. Your doctor will diagnose IE based on your risk factors, medical history, signs and symptoms, and lab and heart tests. Early treatment can help you avoid complications. Treatment usually involves high-dose antibiotics. If your heart valve is damaged, you may need surgery. If you're at risk for IE, brush and floss your teeth regularly, and have regular dental checkups. Germs from a gum infection can enter your bloodstream. If you are at high risk, your doctor might prescribe antibiotics before dental work and certain types of surgery. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Endocarditis is related to marantic endocarditis and infective endocarditis, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Endocarditis is LACTB (Lactamase Beta), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Allograft rejection. The drugs Methylprednisolone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include heart, colon and lung, and related phenotypes are cardiovascular system and hematopoietic system

Disease Ontology : 12 A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves.

PubMed Health : 62 About endocarditis: Endocarditis (EN-do-kar-DI-tis) is an infection of the inner lining of the heart chambers and valves. This lining is called the endocardium (en-do-KAR-de-um). The condition also is called infective endocarditis (IE). The term "endocarditis" also is used to describe an inflammation of the endocardium due to other conditions. This article only discusses endocarditis related to infection. IE occurs if bacteria, fungi, or other germs invade your bloodstream and attach to abnormal areas of your heart. The infection can damage your heart and cause serious and sometimes fatal complications. IE can develop quickly or slowly; it depends on what type of germ is causing it and whether you have an underlying heart problem. When IE develops quickly, it's called acute infective endocarditis. When it develops slowly, it's called subacute infective endocarditis.

Wikipedia : 74 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

Related Diseases for Endocarditis

Diseases in the Endocarditis family:

Subacute Bacterial Endocarditis

Diseases related to Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1367)
# Related Disease Score Top Affiliating Genes
1 marantic endocarditis 34.9 SERPINC1 PLAT F2 CRP
2 infective endocarditis 34.5 TNNI3 TNF TLR6 TLR2 PF4 LBP
3 brucellosis 32.9 TNF IL6 IL10 CXCL8 CRP CAT
4 mitral valve disease 32.2 TNNI3 IL10 F2 CRP
5 mitral valve insufficiency 32.2 TNNI3 CRP ALB
6 tricuspid valve disease 32.0 TNNI3 F2 CRP ALB
7 q fever 32.0 TNF TLR2 IL6 IL10
8 rheumatic heart disease 31.9 TNF TLR2 IL6 IL10
9 heart valve disease 31.9 TNNI3 F2 CRP ALB
10 congestive heart failure 31.9 TNNI3 TNF PIK3C2A IL6 CRP ALB
11 tricuspid valve insufficiency 31.8 TNNI3 F2 CRP ALB
12 vasculitis 31.7 TNF IL6 HSPD1 CRP
13 cardiogenic shock 31.6 PLAT IL6 CRP
14 rheumatic fever 31.6 TNF TLR2 IL6 IL10 ALB
15 intracranial embolism 31.5 SERPINC1 PLAT F2 CRP
16 splenic abscess 31.5 LACTB F2 CRP ALB
17 osteomyelitis 31.5 TNF TLR2 IL6 IL10 CXCL8
18 splenic infarction 31.5 SERPINC1 F2 CRP
19 acute kidney failure 31.5 PIK3C2A F2 CAT ALB
20 aortitis 31.5 TNF IL6 CRP
21 mitral valve stenosis 31.5 SERPINC1 PF4 F2 CRP
22 septic arthritis 31.5 TLR2 CXCL8 CRP
23 pericarditis 31.4 TNNI3 TNF IL6 CXCL8 CRP ALB
24 haemophilus influenzae 31.4 TNF TLR2 LACTB CXCL8
25 endomyocardial fibrosis 31.3 TNF IL10 EPX
26 myocarditis 31.3 TNNI3 TNF PIK3C2A IL6 IL10 ALB
27 pulmonary embolism 31.3 TNNI3 SERPINC1 PLAT PF4 F2 CRP
28 spondylitis 31.3 TNF IL6 IL10 CRP
29 end stage renal failure 31.3 TNF IL6 CRP CAT ALB
30 mediastinitis 31.3 LACTB F2 CRP ALB
31 cerebrovascular disease 31.2 TNF PLAT IL6 F2 CRP
32 purpura 31.2 TNF SERPINC1 IL6 IL10 F2 CRP
33 liver cirrhosis 31.2 TLR2 SERPINC1 LBP F2 ALB
34 antiphospholipid syndrome 31.2 TNF SERPINC1 PLAT PF4 F2 CRP
35 endophthalmitis 31.2 TNF TLR2 IL6 CXCL8 CRP ALB
36 cellulitis 31.2 TNF IL6 IL10 CRP
37 mycobacterium fortuitum 31.2 LACTB HSPD1 CXCL8
38 pericardial effusion 31.1 TNNI3 PIK3C2A IL6 F2 CRP ALB
39 atrial heart septal defect 31.1 TNNI3 SERPINC1 PLAT F2 CRP ALB
40 cryoglobulinemia 31.1 TNF IL6 IL10
41 toxic shock syndrome 31.1 TNF TLR2 SERPINC1 LBP IL6 IL10
42 diarrhea 31.0 TNF IL6 IL10 CXCL8 ALB
43 branch retinal artery occlusion 31.0 SERPINC1 F2 CRP
44 acquired immunodeficiency syndrome 31.0 TNF IL6 IL10 CRP ALB
45 dermatitis 31.0 TNF TLR2 IL6 IL10 CXCL8
46 thrombosis 31.0 SERPINC1 PLAT PF4 F2
47 kawasaki disease 31.0 TNF IL6 IL10 HSPD1 CRP ALB
48 candidiasis 31.0 TNF TLR2 IL6 IL10 CXCL8
49 autoimmune disease 30.9 TNF IL6 IL10 HSPD1 CXCL8 CRP
50 mycobacterium chelonae 30.9 TLR2 CXCL8

Graphical network of the top 20 diseases related to Endocarditis:



Diseases related to Endocarditis

Symptoms & Phenotypes for Endocarditis

UMLS symptoms related to Endocarditis:


angina pectoris, edema, chest pain

MGI Mouse Phenotypes related to Endocarditis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.13 ADSL ALB CRP F2 IL10 IL6
2 hematopoietic system MP:0005397 10.03 EPX F2 IL10 IL6 LBP PF4
3 homeostasis/metabolism MP:0005376 10.03 ALB CAT CRP EPX F2 IL10
4 immune system MP:0005387 9.77 ALB CRP EPX F2 IL10 IL6
5 muscle MP:0005369 9.23 ALB HSPD1 IL10 IL6 PLAT TLR2

Drugs & Therapeutics for Endocarditis

PubMed Health treatment related to Endocarditis: 62

Infective endocarditis (IE) is treated with antibiotics and sometimes with heart surgery .

Drugs for Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 254)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
6
Aminocaproic acid Approved, Investigational Phase 4 60-32-2 564
7
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
8
Clarithromycin Approved Phase 4 81103-11-9 84029
9
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
10
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
11
Imipenem Approved Phase 4 64221-86-9, 74431-23-5 104838
12
Hexetidine Approved, Investigational Phase 4 141-94-6
13
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
14
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
15
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
16
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
17
Norepinephrine Approved Phase 4 51-41-2 439260
18
Dobutamine Approved Phase 4 34368-04-2 36811
19
Racepinephrine Approved Phase 4 329-65-7 838
20
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
21
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
22
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
23
Oritavancin Approved, Investigational Phase 4 171099-57-3 16129632
24
Fosfomycin Approved Phase 4 23155-02-4 446987
25
Cloxacillin Approved, Investigational, Vet_approved Phase 4 61-72-3 6098
26
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
27
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
28
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
29
Cephalexin Approved, Investigational, Vet_approved Phase 4 15686-71-2 27447
30
Vancomycin Approved Phase 4 1404-90-6 441141 14969
31
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
32
Ceftaroline fosamil Approved, Investigational Phase 4 229016-73-3
33
Linezolid Approved, Investigational Phase 4 165800-03-3 441401
34
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
35
Posaconazole Approved, Investigational, Vet_approved Phase 4 171228-49-2 147912
36
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
37
Simendan Investigational Phase 4 131741-08-7
38 Hemostatics Phase 4
39 Coagulants Phase 4
40 Anticoagulants Phase 4
41 Antineoplastic Agents, Hormonal Phase 4
42 Anti-Inflammatory Agents Phase 4
43 Methylprednisolone Acetate Phase 4
44 Antiviral Agents Phase 4
45 Neuroprotective Agents Phase 4
46 glucocorticoids Phase 4
47 Antifibrinolytic Agents Phase 4
48 N-monoacetylcystine Phase 4
49 Free Radical Scavengers Phase 4
50 Antioxidants Phase 4

Interventional clinical trials:

(show top 50) (show all 228)
# Name Status NCT ID Phase Drugs
1 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Unknown status NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
2 Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study: a Multicenter, Prospective, Randomized Trial Comparing the State-of-the-Art Therapeutic Strategy Versus Early Surgery Strategy in Infective Endocarditis Unknown status NCT00624091 Phase 4
3 Pharmacokinetics/ Pharmacodynamics (PK/PD) Study of Vancomycin in the Treatment of Methicillin-resistant Staphylococcus Aureus(MRSA) Blood Stream Infection (Septicemia) and Endocarditis in Chinese Patients Unknown status NCT02443064 Phase 4 Vancomycin
4 Randomized Clinical Trial to Verify the Effectiveness of Topical Aminocaproic Acid in the Prevention of Post-exodontic Bleeding in Patients on Anticoagulants Unknown status NCT02238288 Phase 4 Aminocaproic acid;lidocaine and epinephrine;Paracetamol
5 The Effect of 6-Methyl-Prednisolone on Organ Dysfunction and Mortality of Patients With Unresolving Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4 6-methyl-prednisolone
6 Comparison of the Efficacy of Triple Therapy With or Without Acetylcysteine in the First Line of Helicobacter Pylori Infection- A Multicenter Randomized Comparative Trial Unknown status NCT02249546 Phase 4 N-acetylcysteine + PPI-amoxicillin-clarithromycin;PPI-amoxicillin-clarithromycin
7 Evaluation of the Efficacy and Safety of Fosfomycin Plus Imipenem for the Treatment of Methicillin-resistant Staphylococcus Aureus (MRSA) Infective Endocarditis. Completed NCT00871104 Phase 4 Fosfomycin and imipenem;Vancomycin
8 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Completed NCT01920126 Phase 4 sodium bicarbonate;Saline
9 Partial Oral Treatment of Endocarditis Completed NCT01375257 Phase 4 Oral treatment with antibiotics for endocarditis;Guideline treatment with parenteral antibiotics
10 A Randomized Comparison of Early Surgery Versus Conventional Treatment Strategy in Patients With High Embolic Risk of Infective Endocarditis Completed NCT00750373 Phase 4
11 Health Economic Evaluation of Rapid Detection of Bacteraemia and Fungemia by Real Time PCR for Cases of Febrile Neutropenia, Suspicion of Endocarditis and Severe Sepsis in Intensive Care Units Completed NCT00709358 Phase 4
12 Influence of Pre-procedural Oral Rinse in the Induced Bacteremia by Periodontal Instrumentation: a Randomized Clinical Trial Completed NCT02215473 Phase 4 Chlorhexidine gluconate mouth rinse
13 A Comparative Evaluation of the Safety and Efficacy of Daptomycin Versus Standard of Care in Pediatric Subjects One - Seventeen Years of Age With Bacteremia Caused by Staphylococcus Aureus. Completed NCT01728376 Phase 4 Daptomycin;Comparator
14 The Use of Antifungal Lock Therapy in Intestinal Failure and Other Patients Completed NCT00936910 Phase 4 amphotericin B liposomal (Ambisome)
15 The Effects of Levosimendan on Renal Function in Patients With Low Ejection Fraction Undergoing Mitral Valve Surgery. Completed NCT01969071 Phase 4 Levosimendan;Dobutamine
16 Comparative Study of Hemodynamic Changes Caused by Diazepam and Midazolam During Third Molar Surgery. A Prospective Randomized Study Completed NCT02177955 Phase 4 7.5 mg Midazolam;10 mg diazepam
17 Bacteraemia Secondary to Tooth Extraction: a Randomized Clinical Trial on Efficacy of Three Different Chlorhexidine Prophylaxis Protocols Completed NCT02150031 Phase 4 0.2% Chlorhexidine;1% Chlorhexidine;1% Chlorhexidine;Lidocaine plus adrenaline
18 An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Recruiting NCT02783404 Phase 4 Amoxicillin;Amoxicillin-Potassium Clavulanate
19 A Pilot Proof of Concept Single-Center Study of the Use of Oritavancin in Systemic Staphylococcus Aureus Infections in Patients With Opioid Use Disorder Recruiting NCT03761953 Phase 4 Oritavancin Injection
20 People Who Inject Drugs; Longitudinal Staphylococcus Aureus Colonization Pattern and the Impact on Infection Frequency by Regular Showers With Chlorhexidine Active, not recruiting NCT03940729 Phase 4 Chlorhexidine Topical
21 Plasma Concentrations of Amoxicillin Administered in High-doses During the First Week of Treatment : Intra- and Inter-individual Variability, Factors Associated With Overdose and Adverse Events Not yet recruiting NCT04070469 Phase 4 Amoxicillin
22 Multicenter, Randomised, Open-label Phase III-IV Study to Evaluate the Efficacy of Cloxacillin and Fosfomycin Combination Versus Cloxacillin Monotherapy in Adult Patients With Methicillin-susceptible Staphylococcus Aureus Bacteraemia: the SAFO Trial. Not yet recruiting NCT03959345 Phase 4 Combination therapy group;Standard therapy group
23 Impact of Antibiotic Treatment Following Implantation of Cardiac Electronic Device on Patient's Outcome Not yet recruiting NCT03148444 Phase 4 cefalexin 500 mg qid or roxithromycin 150 mg bid
24 Pilot Randomised Controlled Trial of Penicillin Versus Flucloxacillin for Definitive Treatment of Invasive Penicillin Susceptible Staphylococcus Aureus Not yet recruiting NCT03632642 Phase 4 Benzylpenicillin;Flucloxacillin
25 Open Label Study to Assess the Efficacy and Safety of Daptomycin in Combination With Anti-Cell Wall Active Therapy in the Treatment of Enterococcal Endocarditis Terminated NCT00401960 Phase 4 Daptomycin
26 A Phase 4 Multicenter, Randomized, Double Blind Study to Describe the Efficacy and Safety of Cubicin® (Daptomycin for Injection) With and Without Initial Gentamicin Combination Therapy in the Treatment of S. Aureus Infective Endocarditis Terminated NCT00638157 Phase 4 daptomycin;daptomycin and gentamicin
27 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
28 The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study Terminated NCT00164099 Phase 4 Synbiotic 2000
29 Open Label, Limited Access Protocol of Posaconazole in Invasive Fungal Infections Study PO2095 Terminated NCT00177749 Phase 4 Posaconazole
30 Effect of Rituximab in Treatment of Primary Membranoproliferative Glomerulonephritis Unknown status NCT03180723 Phase 3 Rituximab;Cyclosporin
31 Perceval S Valve Clinical Trial for Extended CE Mark Unknown status NCT01368666 Phase 2, Phase 3
32 Randomized Controlled Trial Comparing Long and Short Duration of Antibiotic Prophylaxis for Patients Undergoing Sinus Lift Surgery Unknown status NCT02764710 Phase 3 Amoxicillin-Potassium Clavulanate Combination
33 "Salvage Use" of Recombinant Activated Factor VII After Inadequate Haemostatic Response to Conventional Therapy in Complex Cardiac Surgery - a Randomised Placebo Controlled Trial Unknown status NCT00214656 Phase 3 Recombinant Activated Factor VII
34 A Phase 3, Multicenter, Randomized, Open-Label, Comparative Study to Assess the Safety and Efficacy of Daptomycin Compared to Conventional Therapy In the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to Staph Aureus Completed NCT00093067 Phase 3 daptomycin
35 A Phase III Randomized, Open-labeled Clinical Trial of MK-3009 (Daptomycin) in Patients With Skin and Soft Tissue Infections, Septicemia and Right-sided Infective Endocarditis Caused by MRSA Completed NCT00770341 Phase 3 Daptomycin 4 mg/kg;Comparator: vancomycin;Daptomycin 6 mg/kg
36 Population Pharmacokinetic (PK) Study of Multiple Doses of Cubicin® (Daptomycin) 10 mg/kg in Critical Care Patients Having Bacteremia, Endocarditis or Skin Soft Tissue Infections Due to Gram Positive Bacteria With Various Degrees of Renal Failure Completed NCT02142075 Phase 3 Daptomycin
37 A Multicenter, Randomized, Double-Blinded Comparative Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Daptomycin Versus Active Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis Due to Gram-Positive Organisms Completed NCT01922011 Phase 3 Daptomycin;Vancomycin (or equivalent);Nafcillin (or equivalent)
38 Conservative Aortic Valve Surgery for Aortic Insufficiency and Aneurysms of the Aortic Root Completed NCT00478803 Phase 3
39 Treatment With Cotrimoxazole vs. Vancomycin for Infections Caused by Methicillin-resistant Staphylococcus Aureus: Randomized Controlled Trial Completed NCT00427076 Phase 3 Cotrimoxazole;Vancomycin
40 Health Promotion and Public Safety: Community-based Collaborative Services to Addicted Offenders Completed NCT01843751 Phase 3 buprenorphine/naloxone
41 A Randomized, Double-blind, Multi-center Study to Establish the Efficacy and Safety of Ceftobiprole Medocaril Compared to Daptomycin in the Treatment of Staphylococcus Aureus Bacteremia, Including Infective Endocarditis Recruiting NCT03138733 Phase 3 Ceftobiprole medocaril;Daptomycin
42 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus (Relais Oral Dans le Traitement Des Endocardites à Staphylocoques Multi-sensibles) Recruiting NCT02701608 Phase 3 Levofloxacin;Rifampicin
43 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus (Relais Oral Dans le Traitement Des Endocardites à Streptocoques Multi-sensibles) Recruiting NCT02701595 Phase 3 Amoxicillin
44 Early Oral Switch Therapy in Low-risk Staphylococcus Aureus Bloodstream Infection Recruiting NCT01792804 Phase 3 Trimethoprim-Sulfamethoxazole;Clindamycin;Linezolid;Flucloxacillin;Cloxacillin;Vancomycin;Daptomycin;Cefazolin
45 A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of a Single Dose of Exebacase in Adult Patients Receiving Standard-of-Care Antibiotics for the Treatment of Staphylococcus Aureus Bloodstream Infections (Bacteremia), Including Right-Sided Infective Endocarditis Not yet recruiting NCT04160468 Phase 3 Exebacase;Placebo
46 Role of (LMWH) in Prevention of Thromboembolic Complication After (TACE) in Hepatocellular Carcinoma. Not yet recruiting NCT02715492 Phase 3 LMWH
47 A Randomized Placebo-controlled Double-blinded Trial of the Treatment of MRSA Throat Carriage With Either Standard Decolonization Therapy or Standard Decolonization Therapy Combined With Oral Clindamycin Not yet recruiting NCT04104178 Phase 3 Clindamycin;Placebo
48 A Phase 3 Multicenter, Randomized, Open-label, Clinical Trial of Telavancin Versus Standard Intravenous Therapy in the Treatment of Subjects With Staphylococcus Aureus Bacteremia Including Infective Endocarditis Terminated NCT02208063 Phase 3 Telavancin;Vancomycin;Daptomycin;Synthetic penicillin;Cefazolin
49 Evaluation de la rhAnnexine V-128 radiomarquée Dans le Diagnostic de l'Endocardite Infectieuse, du Thrombus Atrial et de Leurs Complications Emboliques associées Unknown status NCT02459613 Phase 1, Phase 2
50 A Randomized Study of the Effects of Perioperative i.v. Ketorolac-lidocaine on the Hemodynamic Response in the Patients With Valvular Heart Diseases During Cesarean Delivery Unknown status NCT01571791 Phase 2 Placebo;Ketorolac-Lidocaine

Search NIH Clinical Center for Endocarditis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


GENTAMICIN SULFATE PWDR

Cochrane evidence based reviews: endocarditis

Genetic Tests for Endocarditis

Anatomical Context for Endocarditis

MalaCards organs/tissues related to Endocarditis:

40
Heart, Colon, Lung, Liver, Brain, Kidney, Skin

Publications for Endocarditis

Articles related to Endocarditis:

(show top 50) (show all 30003)
# Title Authors PMID Year
1
Short-term exposure to particulate matters is associated with septic emboli in infective endocarditis. 61 42
31702666 2019
2
What is the best management option for non-significant residual shunt after device closure of perimembranous ventricular septal defect: A case report based on the lessons from post-procedure endocarditis. 61 42
31626092 2019
3
Diagnosis of infective endocarditis using echocardiography. 61 42
31567953 2019
4
Fibronectin-binding proteins and clumping factor A in Staphylococcus aureus experimental endocarditis: FnBPA is sufficient to activate human endothelial cells. 54 61
17393025 2007
5
Safety evaluation of Lactobacillus delbrueckii subsp. lactis UO 004, a probiotic bacterium. 54 61
15748979 2005
6
Bartonella koehlerae, a new cat-associated agent of culture-negative human endocarditis. 54 61
15297484 2004
7
Haemophilus parainfluenzae endocarditis in a patient with mitral valve prolapse. 54 61
8323254 1993
8
Activity of ampicillin plus sulbactam against beta-lactamase producing enterococci in experimental endocarditis. 54 61
8444668 1993
9
Killing curve activity of ciprofloxacin is comparable to synergistic effect of beta-lactam-tobramycin combinations against Haemophilus species endocarditis strains. 54 61
1389104 1992
10
Bromide-dependent toxicity of eosinophil peroxidase for endothelium and isolated working rat hearts: a model for eosinophilic endocarditis. 54 61
1985118 1991
11
Efficacy of amoxycillin/clavulanic acid in experimental Staphylococcus aureus endocarditis in the rat. 54 61
2050588 1991
12
Endocarditis following ocrelizumab in relapsing-remitting MS. 61
32014890 2020
13
Multimodal ophthalmic imaging of staphylococcus aureus bacteremia associated with chorioretinitis, endocarditis, and multifocal brain abscesses. 61
31886435 2020
14
Modes of bioprosthetic valve failure: a narrative review. 61
31972604 2020
15
Fungal endocarditis resembling primary cardiac malignancy in a patient with B-cell ALL with culture confirmation. 61
31768196 2020
16
Successful treatment of methicillin-sensitive Staphylococcus aureus tricuspid-valve endocarditis with dalbavancin as an outpatient in a person who injects drugs: A case report. 61
31841726 2020
17
Infective endocarditis: When an image surprises the echocardiographer. 61
32033826 2020
18
Response to: Infective endocarditis and its neurological complications. 61
31268534 2020
19
Virulence of beta-hemolytic streptococci in infective endocarditis. 61
31520396 2020
20
Native valve Staphylococcus capitis infective endocarditis: a mini review. 61
31079347 2020
21
Rapid Diagnosis of Infective Endocarditis Using Pocket-Sized Ultrasound. 61
31419418 2020
22
Molecular Imaging of Cardiovascular Device Infection: Targeting the Bacteria or the Host-Pathogen Immune Response? 61
32034110 2020
23
Oral surgery related fungal endocarditis: The need for a novel concept in endocarditis prophylaxy. 61
31739080 2020
24
Early Operation and Establishment of an Endocarditis Team. 61
31534093 2020
25
Author reply: Early Operation and Establishment of an Endocarditis Team. 61
31534096 2020
26
Pulmonary valve infective endocarditis with atrial septal defect and pulmonary valve disease-too coincidental to be true? 61
32034668 2020
27
Procalcitonin, white blood cell count and C-reactive protein as predictors of S. aureus infection and mortality in infective endocarditis. 61
31405585 2020
28
Native valve infective endocarditis due to ampicillin-resistant Escherichia coli in the postoperative period of a right radical nephrectomy due to xanthogranulomatous pyelonephritis. 61
31757432 2020
29
Relationship of oral conditions to the incidence of infective endocarditis in periodontitis patients with valvular heart disease: a cross-sectional study. 61
31197658 2020
30
Successful long-term antibiotic suppressive therapy in a case of prosthetic valve endocarditis and a case of extensive aortic and subclavian graft infection. 61
31123929 2020
31
Hypertrophic obstructive cardiomyopathy and mitral regurgitation in Libman-Sacks endocarditis. 61
30519962 2020
32
Endomyocardial biopsies in the diagnosis of myocardial involvement in systemic lupus erythematosus. 61
31924147 2020
33
Predictive factors and long-term prognosis of transcatheter aortic valve implantation-associated endocarditis. 61
32020270 2020
34
Late infective endocarditis after transcatheter tricuspid valve-in-valve implantation: A pediatric case report. 61
31955957 2020
35
Reactive oxygen species induce antibiotic tolerance during systemic Staphylococcus aureus infection. 61
31819212 2020
36
Metastatic infection during Staphylococcus aureus bacteremia. 61
31676266 2020
37
Classical endocarditis with systemic embolization. 61
31584669 2020
38
"Crab-like" mitral valve endocarditis. 61
31816121 2020
39
Addressing the Menace of Enterococcal Endocarditis. 61
32029131 2020
40
A Contemporary Picture of Enterococcal Endocarditis. 61
32029130 2020
41
[Streptococcus agalactiae infective endocarditis]. 61
32030933 2020
42
High level of D-dimer predicts ischemic stroke in patients with infective endocarditis. 61
32017240 2020
43
Acute Ischemic Stroke Treatment in Infective Endocarditis: Systematic Review. 61
32024600 2020
44
Republished: Intracranial vessel occlusion preceding the development of mycotic aneurysms in patients with endocarditis. 61
31937601 2020
45
Coxiella burnetii endocarditis as a possible cause of ANCA-associated vasculitis. 61
32025729 2020
46
A Curious Case of Endocarditis and Liver Abscess in a Previously Healthy Man. 61
31421067 2020
47
The Role of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Diagnosis of Left-sided Endocarditis: Native vs Prosthetic Valves Endocarditis. 61
30949690 2020
48
Higher incidence of perivalvular abscess determines perioperative clinical outcome in patients undergoing surgery for prosthetic valve endocarditis. 61
32013875 2020
49
Streptococcus suis suilysin compromises the function of a porcine tracheal epithelial barrier model. 61
31816403 2020
50
Simultaneous pacing from two branches of coronary sinus in a patient with prosthetic tricuspid valve and complete heart block. 61
32039709 2020

Variations for Endocarditis

Expression for Endocarditis

Search GEO for disease gene expression data for Endocarditis.

Pathways for Endocarditis

Pathways related to Endocarditis according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.07 TNF TLR6 TLR2 LBP IL6 IL10
2
Show member pathways
12.79 TNF IL6 IL10 HSPD1 EPX CXCL8
3
Show member pathways
12.28 TNF TLR2 IL6 CXCL8
4
Show member pathways
12.28 TNF PF4 IL6 IL10 CXCL8
5 12.25 TNF IL6 F2 CXCL8
6
Show member pathways
12.2 TNF TLR6 TLR2 IL6 CXCL8
7
Show member pathways
12.17 TNF TLR2 IL6 CXCL8
8 12.14 TNF TLR6 TLR2 IL6
9 12.12 TNF IL6 IL10 HSPD1 CXCL8
10
Show member pathways
12.11 SERPINC1 PLAT PF4 F2
11
Show member pathways
12.1 TNF TLR6 TLR2 LBP IL6 CXCL8
12
Show member pathways
12.03 TNF PLAT IL6 F2 CRP CAT
13
Show member pathways
11.99 TNF TLR6 TLR2 IL6 IL10
14 11.96 TNF IL6 IL10 CXCL8
15 11.91 TNF LBP IL6 IL10 CXCL8
16 11.84 TNF TLR2 IL6 IL10 CXCL8
17 11.83 TNF TLR2 IL6 CXCL8
18 11.76 TNF TLR6 TLR2 LBP IL6 IL10
19 11.74 LBP IL6 CXCL8
20 11.72 TNF IL6 IL10 CXCL8
21 11.7 TNF IL6 IL10
22 11.68 TNF IL6 IL10
23
Show member pathways
11.61 TNF IL6 CXCL8
24 11.61 TNF IL6 CXCL8
25 11.49 TNF IL6 IL10 CXCL8
26 11.48 TNF TLR2 IL6 HSPD1 CXCL8
27 11.47 TNF PLAT IL6
28 11.35 TNF IL6 IL10
29 11.35 TNF TLR2 IL6 IL10 CXCL8
30 11.32 TNF IL6 IL10
31
Show member pathways
11.27 TNF TLR6 TLR2 PLAT IL6 HSPD1
32 11.21 TNF IL6 IL10
33 10.95 TNF IL6 CXCL8 CRP

GO Terms for Endocarditis

Cellular components related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.81 SERPINC1 PLAT PIK3C2A LBP HSPD1 F2
2 extracellular region GO:0005576 9.77 TNF SERPINC1 PLAT PF4 LBP IL6
3 extracellular space GO:0005615 9.47 TNF SERPINC1 PLAT PF4 LBP IL6

Biological processes related to Endocarditis according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.02 TNF TLR6 TLR2 PF4 IL6 CRP
2 immune response GO:0006955 10.02 TNF TLR6 TLR2 PF4 IL6 IL10
3 cellular protein metabolic process GO:0044267 9.98 SERPINC1 IL6 F2 ALB
4 defense response to bacterium GO:0042742 9.97 TNF TLR6 LBP IL10 EPX
5 cytokine-mediated signaling pathway GO:0019221 9.97 TNF PF4 LBP IL6 IL10 CXCL8
6 response to hypoxia GO:0001666 9.95 TLR2 PLAT CAT ADSL
7 defense response GO:0006952 9.94 TNF PF4 EPX CXCL8
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 TNF TLR6 TLR2 IL6 CAT
9 response to insulin GO:0032868 9.85 TLR2 IL10 CAT
10 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.85 PF4 F2 CXCL8
11 response to glucocorticoid GO:0051384 9.84 TNF IL6 IL10
12 positive regulation of tumor necrosis factor production GO:0032760 9.83 TLR2 PF4 LBP
13 toll-like receptor signaling pathway GO:0002224 9.81 TLR6 TLR2 LBP
14 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 TNF TLR2 LBP
15 defense response to Gram-positive bacterium GO:0050830 9.8 TNF TLR2 LBP IL6 CRP
16 cellular response to lipopolysaccharide GO:0071222 9.8 TNF PF4 LBP IL6 IL10 CXCL8
17 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.77 TLR6 TLR2 HSPD1
18 microglial cell activation GO:0001774 9.77 TNF TLR6 TLR2
19 positive regulation of interleukin-8 production GO:0032757 9.76 TNF TLR2 LBP
20 acute-phase response GO:0006953 9.73 LBP IL6 F2 CRP
21 leukocyte chemotaxis GO:0030595 9.71 PF4 IL10 CXCL8
22 response to molecule of bacterial origin GO:0002237 9.7 TLR2 IL10 CXCL8
23 cellular response to lipoteichoic acid GO:0071223 9.68 TLR2 LBP
24 opsonization GO:0008228 9.67 LBP CRP
25 positive regulation of JAK-STAT cascade GO:0046427 9.67 TNF IL6 IL10 F2
26 endothelial cell apoptotic process GO:0072577 9.66 TNF IL10
27 cellular response to diacyl bacterial lipopeptide GO:0071726 9.66 TLR6 TLR2
28 negative regulation of cytokine secretion involved in immune response GO:0002740 9.65 TNF IL10
29 negative regulation of MHC class II biosynthetic process GO:0045347 9.64 PF4 IL10
30 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.63 TLR6 TLR2
31 negative regulation of lipid storage GO:0010888 9.63 TNF IL6 CRP
32 nitric oxide metabolic process GO:0046209 9.62 TLR6 TLR2
33 receptor biosynthetic process GO:0032800 9.61 TNF IL10
34 response to inactivity GO:0014854 9.61 IL10 CAT
35 detection of diacyl bacterial lipopeptide GO:0042496 9.57 TLR6 TLR2
36 response to bacterial lipoprotein GO:0032493 9.56 TLR6 TLR2
37 positive regulation of chemokine production GO:0032722 9.56 TNF TLR2 LBP IL6
38 positive regulation of interleukin-6 production GO:0032755 9.55 TNF TLR2 LBP IL6 HSPD1
39 positive regulation of macrophage activation GO:0043032 9.26 TLR6 LBP IL10 HSPD1
40 inflammatory response GO:0006954 9.23 TNF TLR6 TLR2 PF4 IL6 IL10

Molecular functions related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.86 TNF TLR6 TLR2 SERPINC1 LACTB CRP
2 signaling receptor binding GO:0005102 9.72 TLR6 PLAT LBP F2 CAT
3 cytokine activity GO:0005125 9.55 TNF PF4 IL6 IL10 CXCL8
4 lipopeptide binding GO:0071723 9.13 TLR6 TLR2 LBP
5 lipopolysaccharide binding GO:0001530 8.92 TLR2 LBP HSPD1 F2

Sources for Endocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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