MCID: END033
MIFTS: 58

Endocarditis

Categories: Blood diseases, Cardiovascular diseases, Infectious diseases, Respiratory diseases

Aliases & Classifications for Endocarditis

MalaCards integrated aliases for Endocarditis:

Name: Endocarditis 12 74 54 42 44 15 62 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10314
ICD9CM 34 421.9
MeSH 44 D004696
SNOMED-CT 67 56819008 91357005
ICD10 32 I33.9
UMLS 71 C0014118 C0375268

Summaries for Endocarditis

MedlinePlus : 42 Endocarditis, also called infective endocarditis (IE), is an inflammation of the inner lining of the heart. The most common type, bacterial endocarditis, occurs when germs enter your heart. These germs come through your bloodstream from another part of your body, often your mouth. Bacterial endocarditis can damage your heart valves. If untreated, it can be life-threatening. It is rare in healthy hearts. Risk factors include having An abnormal or damaged heart valve An artificial heart valve Congenital heart defects The signs and symptoms of IE can vary from person to person. They also can vary over time in the same person. Symptoms you might notice include fever, shortness of breath, fluid buildup in your arms or legs, tiny red spots on your skin, and weight loss. Your doctor will diagnose IE based on your risk factors, medical history, signs and symptoms, and lab and heart tests. Early treatment can help you avoid complications. Treatment usually involves high-dose antibiotics. If your heart valve is damaged, you may need surgery. If you're at risk for IE, brush and floss your teeth regularly, and have regular dental checkups. Germs from a gum infection can enter your bloodstream. If you are at high risk, your doctor might prescribe antibiotics before dental work and certain types of surgery. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Endocarditis is related to nonbacterial thrombotic endocarditis and infective endocarditis, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Endocarditis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs Clavulanate and Rifampicin have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and kidney, and related phenotypes are Reduced mammosphere formation and cardiovascular system

Disease Ontology : 12 A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves.

PubMed Health : 62 About endocarditis: Endocarditis (EN-do-kar-DI-tis) is an infection of the inner lining of the heart chambers and valves. This lining is called the endocardium (en-do-KAR-de-um). The condition also is called infective endocarditis (IE). The term "endocarditis" also is used to describe an inflammation of the endocardium due to other conditions. This article only discusses endocarditis related to infection. IE occurs if bacteria, fungi, or other germs invade your bloodstream and attach to abnormal areas of your heart. The infection can damage your heart and cause serious and sometimes fatal complications. IE can develop quickly or slowly; it depends on what type of germ is causing it and whether you have an underlying heart problem. When IE develops quickly, it's called acute infective endocarditis. When it develops slowly, it's called subacute infective endocarditis.

Wikipedia : 74 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

Related Diseases for Endocarditis

Diseases in the Endocarditis family:

Subacute Bacterial Endocarditis

Diseases related to Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1510)
# Related Disease Score Top Affiliating Genes
1 nonbacterial thrombotic endocarditis 32.9 SERPINC1 PF4 IL6 F2 CRP APOH
2 infective endocarditis 32.6 TNNI3 TNF TLR2 PF4 LBP IL6
3 aortic valve insufficiency 31.9 TNNI3 F2 CRP ALB
4 mitral valve insufficiency 31.8 TNNI3 PIK3C2A F2 CRP ALB
5 brucellosis 31.7 TNF IL6 IL17A IL10 IFNG CXCL8
6 rheumatic heart disease 31.7 TNF TLR2 IL6 IL10
7 q fever 31.6 TNF TLR2 IL6 IL10 IFNG
8 congestive heart failure 31.6 TNNI3 TNF PIK3C2A IL6 CRP ALB
9 heart valve disease 31.6 TNNI3 F2 CRP APOH ALB
10 tricuspid valve insufficiency 31.5 TNNI3 F2 CRP ALB
11 cardiogenic shock 31.5 TNF IL6
12 intracranial embolism 31.4 SERPINC1 F2 CRP ALB
13 hemopericardium 31.4 TNNI3 F2 CRP
14 acute kidney failure 31.3 PIK3C2A F2 ALB
15 hypereosinophilic syndrome 31.3 IL10 IFNG EPX CXCL8
16 splenic abscess 31.3 LACTB F2 CRP ALB
17 mitral valve disease 31.3 TNNI3 IL10 F2 CRP
18 mitral valve stenosis 31.3 SERPINC1 PF4 F2 CRP
19 pericarditis 31.3 TNNI3 TNF IL6 IFNG CXCL8 CRP
20 rheumatic fever 31.3 TNF TLR2 IL6 IL10 IFNG ALB
21 septic arthritis 31.2 TLR2 IFNG CXCL8 CRP
22 vasculitis 31.2 TNF IL6 IL17A HSPD1 CRP APOH
23 antiphospholipid syndrome 31.2 TNF SERPINC1 PF4 F2 CRP APOH
24 atrial heart septal defect 31.2 TNNI3 SERPINC1 F2 CRP ALB
25 splenic infarction 31.1 SERPINC1 F2 CRP APOH ALB
26 osteomyelitis 31.1 TNF TLR2 IL6 IL10 IFNG CXCL8
27 haemophilus influenzae 31.1 TNF TLR2 LACTB CXCL8
28 end stage renal disease 31.1 TNF IL6 IL10 CRP ALB
29 pulmonary embolism 31.1 TNNI3 SERPINC1 GP1BA F2 CRP APOH
30 endomyocardial fibrosis 31.1 TNF IL10 EPX
31 penicillin allergy 31.1 LACTB IL10 IFNG
32 aortitis 31.1 TNF IL6 IL17A CRP
33 endophthalmitis 31.0 TNF TLR2 IL6 CXCL8 CRP ALB
34 mediastinitis 31.0 LACTB F2 CRP ALB
35 pericardial effusion 31.0 TNNI3 PIK3C2A IL6 F2 CRP ALB
36 epidural abscess 31.0 F2 CRP ALB
37 disseminated intravascular coagulation 31.0 TNF SERPINC1 PIK3C2A IL6 IL10 F2
38 tricuspid valve disease 31.0 TNNI3 F2 CRP ALB
39 myocarditis 30.9 TNNI3 TNF PIK3C2A IL6 IL17A IL10
40 cardiac tamponade 30.9 TNNI3 PIK3C2A F2 CRP ALB
41 mycobacterium fortuitum 30.9 LACTB HSPD1 CXCL8
42 toxic shock syndrome 30.9 TNF TLR2 SERPINC1 LBP IL6 IL10
43 pleural empyema 30.9 IL6 F2 CRP ALB
44 chronic kidney disease 30.9 TNNI3 TNF IL6 IL10 CXCL8 CRP
45 limb ischemia 30.9 TNNI3 TNF IL6 F2
46 cryoglobulinemia 30.9 TNF IL6 IFNG
47 thrombophlebitis 30.8 SERPINC1 F2 CRP APOH ALB
48 cellulitis 30.8 TNF LACTB IL6 F2 CRP ALB
49 thrombosis 30.8 SERPINC1 PF4 GP1BA F2 APOH
50 spondylitis 30.8 TNF IL6 IL17A IL10 IFNG CRP

Graphical network of the top 20 diseases related to Endocarditis:



Diseases related to Endocarditis

Symptoms & Phenotypes for Endocarditis

UMLS symptoms related to Endocarditis:


angina pectoris, chest pain, edema

GenomeRNAi Phenotypes related to Endocarditis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ALB CXCL8 GP1BA HSPD1 IL17A PIK3C2A

MGI Mouse Phenotypes related to Endocarditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.25 ALB CRP F2 HSPD1 IFNG IL10
2 homeostasis/metabolism MP:0005376 10.25 ALB APOH CRP EPX F2 GP1BA
3 hematopoietic system MP:0005397 10.18 EPX GP1BA HSPD1 IFNG IL10 IL17A
4 immune system MP:0005387 10.07 ALB CRP EPX F2 IFNG IL10
5 digestive/alimentary MP:0005381 10.01 ALB F2 IFNG IL10 IL17A IL6
6 liver/biliary system MP:0005370 9.76 ALB IFNG IL10 IL6 LBP SERPINC1
7 muscle MP:0005369 9.65 ALB F2 HSPD1 IFNG IL10 IL6
8 respiratory system MP:0005388 9.28 F2 HSPD1 IFNG IL10 IL17A IL6

Drugs & Therapeutics for Endocarditis

PubMed Health treatment related to Endocarditis: 62

Infective endocarditis (IE) is treated with antibiotics and sometimes with heart surgery .

Drugs for Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 145)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
2
Rifampicin Approved Phase 4 13292-46-1 5458213 5381226
3
Imipenem Approved Phase 4 64221-86-9, 74431-23-5 104838
4
tannic acid Approved Phase 4 1401-55-4
5
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
6
Oritavancin Approved, Investigational Phase 4 171099-57-3 16129632
7
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
8
Vancomycin Approved Phase 4 1404-90-6 441141 14969
9
Ceftaroline fosamil Approved, Investigational Phase 4 229016-73-3
10
Linezolid Approved, Investigational Phase 4 165800-03-3 441401
11 Amoxicillin-Potassium Clavulanate Combination Phase 4
12 Anesthetics Phase 4
13 Analgesics, Opioid Phase 4
14 Antitubercular Agents Phase 4
15 Anti-Infective Agents Phase 4
16 Anti-Bacterial Agents Phase 4
17 Antibiotics, Antitubercular Phase 4
18 methicillin Phase 4
19 Gentamicins Phase 4
20
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
21
Ofloxacin Approved Phase 3 82419-36-1 4583
22
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
23
Ceftriaxone Approved Phase 3 73384-59-5 5479530 5361919
24
Netilmicin Approved, Investigational Phase 3 56391-56-1 441306 6857423
25
Procaine Approved, Investigational, Vet_approved Phase 3 59-46-1 4914
26
Penicillin G Approved, Vet_approved Phase 3 61-33-6 5904
27
Aztreonam Approved Phase 3 78110-38-0 5362041 5742832
28
Ceftobiprole Approved, Investigational Phase 3 209467-52-7 6918430
29
Oxacillin Approved, Investigational Phase 3 66-79-5 6196
30
Cloxacillin Approved, Investigational, Vet_approved Phase 3 61-72-3 6098
31
Cefazolin Approved Phase 3 25953-19-9 656510 33255
32
Telavancin Approved Phase 3 372151-71-8
33
Nafcillin Approved, Investigational Phase 3 147-52-4, 985-16-0 8982
34
Ceftobiprole medocaril Experimental, Investigational Phase 3 376653-43-9
35 Cytochrome P-450 Enzyme Inhibitors Phase 3
36 Fluoroquinolones Phase 3
37 Penicillin G Procaine Phase 3
38 Penicillin G Benzathine Phase 3
39 penicillins Phase 3
40
Dalbavancin Approved, Investigational Phase 2 171500-79-1, 91097-81-3 122186
41 Annexin A5 Phase 1, Phase 2
42
Dexmedetomidine Approved, Vet_approved 113775-47-6 68602 5311068
43
Povidone Approved 9003-39-8 131751496
44 Prednisolone acetate Approved, Vet_approved 52-21-1
45
Amikacin Approved, Investigational, Vet_approved 37517-28-5 37768
46
Cidofovir Approved 113852-37-2 60613
47
Prednisolone Approved, Vet_approved 50-24-8 5755
48
Cefepime Approved, Investigational 88040-23-7 5479537
49
Aminocaproic acid Approved, Investigational 60-32-2 564
50
Tazobactam Approved 89786-04-9 123630

Interventional clinical trials:

(show top 50) (show all 107)
# Name Status NCT ID Phase Drugs
1 An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Unknown status NCT02783404 Phase 4 Amoxicillin;Amoxicillin-Potassium Clavulanate
2 Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study: a Multicenter, Prospective, Randomized Trial Comparing the State-of-the-Art Therapeutic Strategy Versus Early Surgery Strategy in Infective Endocarditis Unknown status NCT00624091 Phase 4
3 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Unknown status NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
4 Pharmacokinetics/ Pharmacodynamics (PK/PD) Study of Vancomycin in the Treatment of Methicillin-resistant Staphylococcus Aureus(MRSA) Blood Stream Infection (Septicemia) and Endocarditis in Chinese Patients Unknown status NCT02443064 Phase 4 Vancomycin
5 A Randomized Comparison of Early Surgery Versus Conventional Treatment Strategy in Patients With High Embolic Risk of Infective Endocarditis Completed NCT00750373 Phase 4
6 Evaluation of the Efficacy and Safety of Fosfomycin Plus Imipenem for the Treatment of Methicillin-resistant Staphylococcus Aureus (MRSA) Infective Endocarditis. Completed NCT00871104 Phase 4 Fosfomycin and imipenem;Vancomycin
7 Partial Oral Treatment of Endocarditis Completed NCT01375257 Phase 4 Oral treatment with antibiotics for endocarditis;Guideline treatment with parenteral antibiotics
8 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Completed NCT01920126 Phase 4 sodium bicarbonate;Saline
9 Health Economic Evaluation of Rapid Detection of Bacteraemia and Fungemia by Real Time PCR for Cases of Febrile Neutropenia, Suspicion of Endocarditis and Severe Sepsis in Intensive Care Units Completed NCT00709358 Phase 4
10 Short-course Antibiotic Regimen Compared to Conventional Antibiotic Treatment for Gram-positive Cocci Infective Endocarditis: Randomized Clinical Trial Recruiting NCT04222257 Phase 4 Antibiotics;Antibiotics
11 A Pilot Proof of Concept Single-Center Study of the Use of Oritavancin in Systemic Staphylococcus Aureus Infections in Patients With Opioid Use Disorder Recruiting NCT03761953 Phase 4 Oritavancin Injection
12 A Phase 4 Multicenter, Randomized, Double Blind Study to Describe the Efficacy and Safety of Cubicin® (Daptomycin for Injection) With and Without Initial Gentamicin Combination Therapy in the Treatment of S. Aureus Infective Endocarditis Terminated NCT00638157 Phase 4 daptomycin;daptomycin and gentamicin
13 Open Label Study to Assess the Efficacy and Safety of Daptomycin in Combination With Anti-Cell Wall Active Therapy in the Treatment of Enterococcal Endocarditis Terminated NCT00401960 Phase 4 Daptomycin
14 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
15 A Phase 3, Multicenter, Randomized, Open-Label, Comparative Study to Assess the Safety and Efficacy of Daptomycin Compared to Conventional Therapy In the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to Staph Aureus Completed NCT00093067 Phase 3 daptomycin
16 A Phase III Randomized, Open-labeled Clinical Trial of MK-3009 (Daptomycin) in Patients With Skin and Soft Tissue Infections, Septicemia and Right-sided Infective Endocarditis Caused by MRSA Completed NCT00770341 Phase 3 Daptomycin 4 mg/kg;Comparator: vancomycin;Daptomycin 6 mg/kg
17 Population Pharmacokinetic (PK) Study of Multiple Doses of Cubicin® (Daptomycin) 10 mg/kg in Critical Care Patients Having Bacteremia, Endocarditis or Skin Soft Tissue Infections Due to Gram Positive Bacteria With Various Degrees of Renal Failure Completed NCT02142075 Phase 3 Daptomycin
18 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus (Relais Oral Dans le Traitement Des Endocardites à Staphylocoques Multi-sensibles) Recruiting NCT02701608 Phase 3 Levofloxacin;Rifampicin
19 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus (Relais Oral Dans le Traitement Des Endocardites à Streptocoques Multi-sensibles) Recruiting NCT02701595 Phase 3 Amoxicillin
20 A Randomized, Double-blind, Multi-center Study to Establish the Efficacy and Safety of Ceftobiprole Medocaril Compared to Daptomycin in the Treatment of Staphylococcus Aureus Bacteremia, Including Infective Endocarditis Recruiting NCT03138733 Phase 3 Ceftobiprole medocaril;Daptomycin
21 A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of a Single Dose of Exebacase in Patients Receiving Standard-of-Care Antibiotics for the Treatment of Staphylococcus Aureus Bloodstream Infections (Bacteremia), Including Right-Sided Infective Endocarditis Recruiting NCT04160468 Phase 3 Exebacase;Placebo
22 A Phase 3 Multicenter, Randomized, Open-label, Clinical Trial of Telavancin Versus Standard Intravenous Therapy in the Treatment of Subjects With Staphylococcus Aureus Bacteremia Including Infective Endocarditis Terminated NCT02208063 Phase 3 Telavancin;Vancomycin;Daptomycin;Synthetic penicillin;Cefazolin
23 Phase II Clinical Trial to Evaluate an Antibiotic Regimen Pharmacokinetic Applicable to Outpatient Parenteral Antimicrobial Therapy in Enterococcus Faecalis Infective Endocarditis Unknown status NCT03681431 Phase 2 Ceftriaxone 4g/ 24h;Ceftriaxone 2g/ 12h
24 Evaluation de la rhAnnexine V-128 radiomarquée Dans le Diagnostic de l'Endocardite Infectieuse, du Thrombus Atrial et de Leurs Complications Emboliques associées Unknown status NCT02459613 Phase 1, Phase 2
25 A Multicenter, Double-Blind, Randomized, Comparative Study of the Safety, Tolerability, Efficacy, and Pharmacokinetics of CF-301 vs. Placebo in Addition to Standard-of-Care Antibacterial Therapy for the Treatment of Adult Patients With Staphylococcus Aureus Bloodstream Infections (Bacteremia) Including Endocarditis Completed NCT03163446 Phase 2 Placebo
26 Hyperbaric Oxygen Treatment in Humans With Gram Positive Cocci Endocarditis" Recruiting NCT04691440 Phase 2 Hyperbaric oxygen
27 A Multi-centre Open Label Randomized Controlled Phase IIB Trial Comparing Vancomycin Versus Daptomycin for the Treatment of MRSA Bacteremia Due to Isolates With High Vancomycin Minimum Inhibitory Concentrations Terminated NCT01975662 Phase 2 Daptomycin;Vancomycin
28 A Phase 2 Multicenter, Randomized, Double-blinded, Study to Describe the Safety, Efficacy, and Pharmacokinetics of Daptomycin 10 mg/kg/Day and Vancomycin for the Treatment of Methicillin-resistant Staphylococcus Aureus Bacteremia Terminated NCT00695903 Phase 2 daptomycin;vancomycin
29 Phase 2, Open-Label, Randomized, Multicenter Study to Compare the Efficacy and Safety of Dalbavancin to Standard of Care Antibiotic Therapy for the Completion of Treatment of Patients With Complicated Bacteremia or Documented Infective Endocarditis Terminated NCT03148756 Phase 2 Dalbavancin;Standard of Care
30 Multi-centre, Randomised, Open Label, Phase IIb Study to Compare the Efficacy, Safety and Pharmacokinetics (PK) of an Optimised Dosing to a Standard Dosing Regimen of Vancomycin in Neonates and Infants Aged ≤ 90 Days With Late Onset Bacterial Sepsis Known or Suspected to be Caused by Gram-positive Microorganisms Terminated NCT02790996 Phase 2 Vancomycin
31 Impact of Setting up a Multidisciplinary Consensus Meeting in the Prognosis and Management of Infectious Endocarditis at Strasbourg University Hospital. Unknown status NCT03429153
32 Beta-lactam Pharmacokinetic Profiles in Patients With Infective Endocarditis Unknown status NCT02033421
33 Study of Autoantibodies in Infective Endocarditis Unknown status NCT00562653
34 Impact of Clinical Care Pathway on Prognosis and Therapeutic Medical Care of Infective Endocarditis Unknown status NCT02856607
35 Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study Unknown status NCT02128139
36 Etiology of Endocarditis in Negative Blood Cultures Unknown status NCT02816307
37 Effect of Dexmedetomidine on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Unknown status NCT02698930 dexmedetomidine;Normal saline
38 The Use of Cardiac Computarized Tomography in Infective Endocarditis Unknown status NCT00550823
39 Detection of the Most Common Micro Organism of Infective Endocarditis in Assiut University Hospital Unknown status NCT03487653
40 Research Interest Antiphospholipid in Predicting Embolic Risk During Infective Endocarditis Unknown status NCT02887079
41 Long-term Clinico-radiological Evolution of Patients With Symptomatic and Asymptomatic Brain Lesions During Infectious Endocarditis Unknown status NCT02252900
42 Positron Emission Tomography Combined With Computed Tomography (PET CT) in Suspected Cardiovascular Implantable Electronic Device Infection, a Pilot Study - PET Guidance I Unknown status NCT02196753
43 Molecular Imaging in Infective Endocarditis Using Hybrid Positron Emission Tomography/Magnetic Resonance Imaging (PET/MR) and Computed Tomography (PET/CT) Unknown status NCT03626571
44 Treatment of Infective Endocarditis by Vancomycin and Gentamycin in Assiut University Children Hospital Unknown status NCT03688659 Vancomycin and gentamycin
45 Clinical Metagenomics of Infective Endocarditis Unknown status NCT03199287
46 Development of the Purification of Human Cardiac Mitochondria, Characterization of These Organelles and Validation of the Model in Acute Endocarditis and Obesity Unknown status NCT03690076
47 Diagnostic Value of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Prosthetic Valve Endocarditis Unknown status NCT01916005
48 Retrospective Evaluation of Safety and Efficacy of Daptomycin Used in Patients With Serious Gram-positive Infections Unknown status NCT01301638
49 Assessment of Diagnostic Accuracy of 18FDG-PET-CT in Patients With Suspicion of Pacing or Defibrillation Lead Infection: a Prospective Multi-center Study Unknown status NCT02251262
50 A Survey of Hospitalizations in Cardiology Units in Sub-Saharan Africa Unknown status NCT03231449

Search NIH Clinical Center for Endocarditis

Inferred drug relations via UMLS 71 / NDF-RT 51 :


GENTAMICIN SULFATE PWDR

Cochrane evidence based reviews: endocarditis

Genetic Tests for Endocarditis

Anatomical Context for Endocarditis

MalaCards organs/tissues related to Endocarditis:

40
Heart, Brain, Kidney, Skin, Endothelial, Colon, Spleen

Publications for Endocarditis

Articles related to Endocarditis:

(show top 50) (show all 30003)
# Title Authors PMID Year
1
Prevalence of Colorectal Neoplasms Among Patients With Enterococcus faecalis Endocarditis in the GAMES Cohort (2008-2017). 42 61
33413809 2021
2
Basilar Artery Dissection Complicated with Infective Endocarditis. 42 61
33455990 2021
3
Mitral Valve Mass in a Patient Suspected of Systemic Lupus: Tumor, Endocarditis or Both? 61 42
33470326 2020
4
Fibronectin-binding proteins and clumping factor A in Staphylococcus aureus experimental endocarditis: FnBPA is sufficient to activate human endothelial cells. 54 61
17393025 2007
5
Bartonella koehlerae, a new cat-associated agent of culture-negative human endocarditis. 54 61
15297484 2004
6
Haemophilus parainfluenzae endocarditis in a patient with mitral valve prolapse. 61 54
8323254 1993
7
Activity of ampicillin plus sulbactam against beta-lactamase producing enterococci in experimental endocarditis. 61 54
8444668 1993
8
Killing curve activity of ciprofloxacin is comparable to synergistic effect of beta-lactam-tobramycin combinations against Haemophilus species endocarditis strains. 54 61
1389104 1992
9
Thiocyanate is the major substrate for eosinophil peroxidase in physiologic fluids. Implications for cytotoxicity. 61 54
2002037 1991
10
Efficacy of amoxycillin/clavulanic acid in experimental Staphylococcus aureus endocarditis in the rat. 61 54
2050588 1991
11
Bromide-dependent toxicity of eosinophil peroxidase for endothelium and isolated working rat hearts: a model for eosinophilic endocarditis. 54 61
1985118 1991
12
Commercial Air Travel for Passengers With Cardiovascular Disease: Recommendations for Less Common Conditions, Considerations for Venous Thromboembolism, and General Guidance. 61
33412348 2021
13
Endomyocardiofibrosis: A Systematic Review. 61
33418479 2021
14
Intravenous Thrombolysis in Acute Ischemic Stroke Patients with Unsuspected Infective Endocarditis. 61
33360518 2021
15
Early experience of aortic surgery during the COVID-19 pandemic in the UK: A multicentre study. 61
33442890 2021
16
Safety and efficacy of mechanical thrombectomy in infective endocarditis: A matched case-control analysis from the German Stroke Registry-Endovascular Treatment. 61
33327038 2021
17
Forgoing transesophageal echocardiogram in selected patients with complicated Staphylococcus aureus bacteremia. 61
33392784 2021
18
Epidemiology, bacteriology, and clinical characteristics of HACEK bacteremia and endocarditis: a population-based retrospective study. 61
32944895 2021
19
Acute Aortic Regurgitation Due to Endocarditis Caused by Disseminated Gonococcal Infection: A Case Report. 61
32976354 2021
20
Trends in Microbiology Data and Association With Mortality in Infective Endocarditis (2002-2017). 61
33387471 2021
21
Temporal changes in the incidence of infective endocarditis in Denmark 1997-2017: A nationwide study. 61
33069786 2021
22
Cochrane corner: a comparison of antibiotic regimens for the treatment of infective endocarditis. 61
33361352 2021
23
Tricuspid Valve Excision Complicated by Postoperative Gerbode Defect Following Recurrent Infective Endocarditis: A Case Report. 61
32851932 2021
24
Streptococcus agalactiae infective endocarditis: analysis of eight surgical cases from a single centre. 61
33356719 2021
25
Infective Endocarditis and Its Short and Long-Term Prognosis in Hemodialysis Patients: A Systematic Review and Meta-analysis. 61
33077294 2021
26
Ascending aorta mycotic aneurysm in a child secondary to subacute infective endocarditis on the basis of congenital aortic stenosis demonstrated by cardiac computerized tomography. 61
33476451 2021
27
An Exploratory Look at Bicuspid Aortic Valve (Bav) Aortopathy: Focus on Molecular and Cellular Mechanisms. 61
31097209 2021
28
Sudden cardiac death-update. 61
33349905 2021
29
Septal and posterior sliding plasty in tricuspid valve endocarditis. 61
33124062 2021
30
Acute Peripheral and/or Cutaneous Ischemic Syndrome: What Rheumatologists Should Know. 61
33315786 2021
31
Structural valve deterioration and mode of failure of stentless bioprosthetic valves. 61
33130282 2021
32
Outcomes of 16,436 patients requiring isolated aortic valve surgery: A statewide cohort study. 61
33181157 2021
33
COVID-19 in patients recovering from cardiac surgery: A surprising mild disease course. 61
33442905 2021
34
Austrian syndrome followed by severe cutaneous adverse reactions in a HIV patient. 61
33071038 2021
35
Ozaki procedure complicated by postpericardiotomy syndrome and cardiac tamponade. 61
32945199 2021
36
Endovascular treatment of a rare case of haemobilia caused by both pseudoaneurysm and a giant hepatic haemangioma. 61
33488900 2021
37
Infective endocarditis with perivalvular abscess complicated by septic embolization with acute ST-segment elevation myocardial infarction and peripheral ischemia. 61
33490364 2021
38
Delayed Presentation of Children to Healthcare Facilities due to COVID-19 Lockdown, Leading to Severe Complications. 61
33576733 2021
39
Candida spp. infective endocarditis: Characteristics and outcomes of twenty patients with a focus on injection drug use as a predisposing risk factor. 61
33073384 2021
40
Isolated tricuspid valve infective endocarditis with multiple septic pulmonary emboli in a patient with atopic dermatitis. 61
33598299 2021
41
Vertebral osteomyelitis as a hidden cause of persistent meningeal irritation in a patient with pneumococcal meningitis: A case report. 61
33578609 2021
42
Adult Congenital Heart Disease Survivors at Age 50 Years: Medical and Psychosocial Status. 61
32713766 2021
43
Pulmonary valve replacement via left anterior minithoracotomy: Lessons learned and early experience. 61
33533086 2021
44
Safety and Efficacy of Daptomycin in Neonates with Coagulase-Negative Staphylococci: Case Series Analysis. 61
33562197 2021
45
PspC domain-containing protein (PCP) determines Streptococcus mutans biofilm formation through bacterial extracellular DNA release and platelet adhesion in experimental endocarditis. 61
33577624 2021
46
Clinical characteristics and outcomes in patients with echocardiographic left ventricular spontaneous echo contrast. 61
33577908 2021
47
Challenges in the diagnosis and management of Granulicatella elegans endocarditis in a 9-year-old child. 61
33602775 2021
48
Kissing Lesion of Mitral Valve - A Case Report. 61
33594867 2021
49
Ceftobiprole Perspective: Current and Potential Future Indications. 61
33567771 2021
50
Validation of VIRSTA and PREDICT scores to determine the priority of echocardiography in patients with Staphylococcus aureus bacteremia. 61
33537758 2021

Variations for Endocarditis

Expression for Endocarditis

Search GEO for disease gene expression data for Endocarditis.

Pathways for Endocarditis

Pathways related to Endocarditis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.37 TNF LBP IL6 IL17A IL10 IFNG
2
Show member pathways
13.09 TNF TLR2 LBP IL6 IL10 IFNG
3
Show member pathways
12.8 TNF IL6 IL17A IL10 IFNG HSPD1
4
Show member pathways
12.78 TNF TLR2 PIK3C2A IL6 F2 CXCL8
5
Show member pathways
12.63 TNF TLR2 IL6 IL17A IL10 IFNG
6
Show member pathways
12.62 TNF TLR2 IL6 IL17A IL10 IFNG
7 12.59 TNF TLR2 IL17A IL10 IFNG
8
Show member pathways
12.59 TNF IL6 IL17A IL10 IFNG F2
9
Show member pathways
12.37 TNF PF4 IL6 IL10 CXCL8
10
Show member pathways
12.36 TNF LBP IL6 IFNG CXCL8
11
Show member pathways
12.35 TNF TLR2 IL6 IL17A IFNG CXCL8
12
Show member pathways
12.32 TNF IL6 IFNG F2 CRP ALB
13
Show member pathways
12.29 TNF IL6 IL17A IL10 IFNG CXCL8
14
Show member pathways
12.28 TNF TLR2 IL6 CXCL8
15
Show member pathways
12.28 TNF TLR2 IL10 IFNG
16 12.21 TNF TLR2 IL6 IFNG
17
Show member pathways
12.19 SERPINC1 PF4 GP1BA F2
18 12.18 TNF IL6 IL10 HSPD1 CXCL8
19
Show member pathways
12.17 TNF TLR2 LBP IL6 IFNG CXCL8
20 12.12 TNF IL6 IL10 CXCL8
21 12.05 TNF IL6 IFNG CXCL8
22 12.02 TNF IL6 IL10 IFNG GP1BA
23 11.96 TNF TLR2 LBP IL6 IL10 IFNG
24
Show member pathways
11.92 LBP IL6 IL17A CXCL8
25
Show member pathways
11.9 TLR2 IL6 IL17A IFNG
26 11.9 TNF LBP IL6 IL17A IL10 CXCL8
27 11.84 TNF IL17A IL10 IFNG
28 11.81 TNF IL6 IL10 CXCL8
29 11.81 TNF TLR2 IL6 IL10 IFNG CXCL8
30 11.79 TNF IL6 IL10 IFNG
31
Show member pathways
11.77 TNF IFNG CXCL8
32 11.74 TNF TLR2 IL6 IL10
33 11.7 TNF TLR2 IL6 IL17A IFNG CXCL8
34
Show member pathways
11.69 TNF IL6 IFNG CXCL8
35 11.68 TNF IL6 CXCL8
36 11.62 IL6 IFNG CXCL8
37 11.58 TNF IL6 IFNG
38 11.56 TNF IL6 IL10 CXCL8
39 11.56 TNF TLR2 IL6 HSPD1 CXCL8
40 11.55 TNF TLR2 IFNG
41 11.55 TNF IL6 GP1BA
42 11.51 TNF IL6 IFNG
43 11.42 TNF IL6 IL10 IFNG
44
Show member pathways
11.41 TNF IL10 IFNG
45 11.39 TNF IL6 IL10
46 11.33 TNF IL6 IL17A IFNG
47
Show member pathways
11.31 TNF TLR2 IL6 IL17A IL10 IFNG
48 11.26 TNF IL6 IL10 IFNG
49 11.23 TLR2 IFNG F2
50 11.05 TNF PF4 IL6 IL17A IL10 CXCL8

GO Terms for Endocarditis

Cellular components related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 SERPINC1 PIK3C2A LBP HSPD1 GP1BA F2
2 extracellular region GO:0005576 9.8 TNF SERPINC1 PF4 LBP IL6 IL17A
3 cell surface GO:0009986 9.63 TNF TLR2 LBP HSPD1 GP1BA APOH
4 extracellular space GO:0005615 9.53 TNF SERPINC1 PF4 LBP IL6 IL17A

Biological processes related to Endocarditis according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.08 TNF TLR2 PF4 IL6 IFNG CXCL8
2 immune response GO:0006955 10.01 TNF TLR2 PF4 IL6 IL17A IL10
3 cellular protein metabolic process GO:0044267 10 SERPINC1 IL6 F2 ALB
4 inflammatory response GO:0006954 10 TNF TLR2 PF4 IL6 IL17A CXCL8
5 response to lipopolysaccharide GO:0032496 9.96 TLR2 LBP IL10 HSPD1
6 defense response GO:0006952 9.95 TNF PF4 EPX CXCL8
7 platelet activation GO:0030168 9.93 PF4 IL6 GP1BA F2
8 positive regulation of inflammatory response GO:0050729 9.91 TNF TLR2 IFNG HSPD1
9 cellular response to lipopolysaccharide GO:0071222 9.91 TNF PF4 LBP IL6 IL10 CXCL8
10 cytokine-mediated signaling pathway GO:0019221 9.91 TNF PF4 LBP IL6 IL17A IL10
11 response to glucocorticoid GO:0051384 9.88 TNF IL6 IL10 HSPD1
12 regulation of insulin secretion GO:0050796 9.87 TNF IL6 IFNG
13 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.87 PF4 F2 CXCL8
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.87 TNF IL6 IFNG
15 positive regulation of interleukin-8 production GO:0032757 9.87 TNF TLR2 LBP IL6
16 positive regulation of interleukin-1 beta production GO:0032731 9.86 TNF IL6 IL17A IFNG
17 humoral immune response GO:0006959 9.85 TNF IL6 IFNG
18 positive regulation of cytokine production GO:0001819 9.85 TNF IL10 IFNG
19 hemostasis GO:0007599 9.84 SERPINC1 GP1BA F2
20 response to activity GO:0014823 9.83 IL6 IL10 HSPD1
21 positive regulation of interleukin-10 production GO:0032733 9.82 TLR2 IL6 HSPD1
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.81 TNF TLR2 LBP
23 microglial cell activation GO:0001774 9.81 TNF TLR2 IFNG
24 positive regulation of interleukin-12 production GO:0032735 9.81 TLR2 IL17A IFNG HSPD1
25 acute-phase response GO:0006953 9.8 LBP IL6 F2 CRP
26 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.79 TNF IL6 IL17A
27 positive regulation of JAK-STAT cascade GO:0046427 9.78 TNF IL6 IL10 F2
28 positive regulation of osteoclast differentiation GO:0045672 9.77 TNF IL17A IFNG
29 positive regulation of macrophage activation GO:0043032 9.77 LBP IL10 HSPD1
30 blood coagulation, intrinsic pathway GO:0007597 9.76 GP1BA F2 APOH
31 defense response to Gram-positive bacterium GO:0050830 9.73 TNF TLR2 LBP IL6 IL17A CRP
32 response to molecule of bacterial origin GO:0002237 9.72 TLR2 IL10 CXCL8
33 cellular response to lipoteichoic acid GO:0071223 9.7 TLR2 LBP
34 negative regulation of fibrinolysis GO:0051918 9.7 F2 APOH
35 negative regulation of lipid storage GO:0010888 9.7 TNF IL6 CRP
36 endothelial cell apoptotic process GO:0072577 9.69 TNF IL10
37 vascular endothelial growth factor production GO:0010573 9.68 TNF IL6
38 opsonization GO:0008228 9.68 LBP CRP
39 negative regulation of MHC class II biosynthetic process GO:0045347 9.67 PF4 IL10
40 negative regulation of cytokine production involved in immune response GO:0002719 9.67 TNF IL10
41 positive regulation of interleukin-23 production GO:0032747 9.65 IL17A IFNG
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.64 TNF IFNG
43 positive regulation of vitamin D biosynthetic process GO:0060557 9.62 TNF IFNG
44 positive regulation of nitrogen compound metabolic process GO:0051173 9.62 TNF IFNG
45 regulation of blood coagulation GO:0030193 9.62 SERPINC1 GP1BA F2 APOH
46 positive regulation of chemokine production GO:0032722 9.55 TNF TLR2 LBP IL6 IFNG
47 positive regulation of tumor necrosis factor production GO:0032760 9.43 TLR2 PF4 LBP IL6 IL17A IFNG
48 positive regulation of interleukin-6 production GO:0032755 9.17 TNF TLR2 LBP IL6 IL17A IFNG

Molecular functions related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.46 SERPINC1 PF4 F2 APOH
2 lipopeptide binding GO:0071723 9.26 TLR2 LBP
3 lipopolysaccharide binding GO:0001530 9.26 TLR2 LBP HSPD1 F2
4 cytokine activity GO:0005125 9.17 TNF PF4 IL6 IL17A IL10 IFNG

Sources for Endocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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