MCID: END033
MIFTS: 58

Endocarditis

Categories: Blood diseases, Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Endocarditis

MalaCards integrated aliases for Endocarditis:

Name: Endocarditis 12 75 55 43 44 15 63 17 72

Classifications:



External Ids:

Disease Ontology 12 DOID:10314
ICD9CM 35 421.9
MeSH 44 D004696
SNOMED-CT 68 56819008 91357005
ICD10 33 I33.9
UMLS 72 C0014118 C0375268

Summaries for Endocarditis

MedlinePlus : 43 Endocarditis, also called infective endocarditis (IE), is an inflammation of the inner lining of the heart. The most common type, bacterial endocarditis, occurs when germs enter your heart. These germs come through your bloodstream from another part of your body, often your mouth. Bacterial endocarditis can damage your heart valves. If untreated, it can be life-threatening. It is rare in healthy hearts. Risk factors include having An abnormal or damaged heart valve An artificial heart valve Congenital heart defects The signs and symptoms of IE can vary from person to person. They also can vary over time in the same person. Symptoms you might notice include fever, shortness of breath, fluid buildup in your arms or legs, tiny red spots on your skin, and weight loss. Your doctor will diagnose IE based on your risk factors, medical history, signs and symptoms, and lab and heart tests. Early treatment can help you avoid complications. Treatment usually involves high-dose antibiotics. If your heart valve is damaged, you may need surgery. If you're at risk for IE, brush and floss your teeth regularly, and have regular dental checkups. Germs from a gum infection can enter your bloodstream. If you are at high risk, your doctor might prescribe antibiotics before dental work and certain types of surgery. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Endocarditis is related to marantic endocarditis and brucellosis, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Endocarditis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and IL-17 Family Signaling Pathways. The drugs Prednisolone phosphate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include heart, colon and brain, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Disease Ontology : 12 A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves.

PubMed Health : 63 About endocarditis: Endocarditis (EN-do-kar-DI-tis) is an infection of the inner lining of the heart chambers and valves. This lining is called the endocardium (en-do-KAR-de-um). The condition also is called infective endocarditis (IE). The term "endocarditis" also is used to describe an inflammation of the endocardium due to other conditions. This article only discusses endocarditis related to infection. IE occurs if bacteria, fungi, or other germs invade your bloodstream and attach to abnormal areas of your heart. The infection can damage your heart and cause serious and sometimes fatal complications. IE can develop quickly or slowly; it depends on what type of germ is causing it and whether you have an underlying heart problem. When IE develops quickly, it's called acute infective endocarditis. When it develops slowly, it's called subacute infective endocarditis.

Wikipedia : 75 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

Related Diseases for Endocarditis

Diseases in the Endocarditis family:

Subacute Bacterial Endocarditis

Diseases related to Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1210)
# Related Disease Score Top Affiliating Genes
1 marantic endocarditis 34.2 SERPINC1 PLAT F2
2 brucellosis 32.5 TNF IL6 IL10 CXCL8 CRP
3 infective endocarditis 32.5 TNNI3 TNF TLR2 LBP IL6 FCGR2A
4 trench fever 32.4 TNF TLR2
5 pericarditis 31.7 TNF IL6 CRP
6 rheumatic fever 31.7 TNF IL6 IL10
7 myocarditis 31.7 TNNI3 TNF IL6
8 exanthem 31.6 TNF IL6 CRP
9 endomyocardial fibrosis 31.6 TNF IL10
10 rheumatic heart disease 31.4 VCAM1 TNF IL6 IL10
11 q fever 31.3 TNF TLR2 IL6 IL10
12 osteomyelitis 31.3 TNF IL6 IL10 CXCL8
13 end stage renal failure 31.3 TNF IL6 CRP ALB
14 pericardial effusion 31.3 PIK3C2A IL6 CRP
15 vasculitis 31.2 VCAM1 TNF CRP APOH
16 spondylitis 31.2 TNF IL6 CRP
17 lupus erythematosus 31.1 TNF IL10 FCGR2A APOH
18 acute cystitis 31.1 IL6 CXCL8 CRP ALB
19 limb ischemia 31.0 TNNI3 TNF IL6
20 septic arthritis 31.0 TLR2 CXCL8 CRP
21 mycobacterium fortuitum 31.0 LACTB HSPD1 CXCL8
22 intracranial embolism 31.0 SERPINC1 PLAT F2
23 haemophilus influenzae 30.9 TNF TLR2 CXCL8
24 adult-onset still's disease 30.9 TNF IL6 CRP
25 arthritis 30.8 TNF IL6 IL10 CXCL8
26 acquired immunodeficiency syndrome 30.8 TNF IL6 IL10 ALB
27 thrombophilia 30.8 SERPINC1 F2 APOH
28 temporal arteritis 30.8 TNF IL6 CRP APOH
29 aspergillosis 30.7 TNF TLR2 IL10
30 cardiogenic shock 30.7 TNF PLAT PIK3C2A IL6
31 fasciitis 30.6 TNF IL6 CXCL8
32 polyarteritis nodosa 30.6 IL6 CRP APOH
33 respiratory failure 30.6 TNF PIK3C2A CXCL8 CRP ALB
34 branch retinal artery occlusion 30.6 SERPINC1 F2 APOH
35 sudden sensorineural hearing loss 30.6 IL6 F2 APOH
36 autoimmune disease 30.6 TNF IL6 IL10 HSPD1 APOH
37 typhoid fever 30.5 TNF IL6 F2 CRP ALB
38 rheumatic disease 30.5 VCAM1 TNF IL10 CRP APOH
39 colitis 30.5 TNF IL6 IL10 CXCL8
40 purpura 30.5 TNF SERPINC1 IL6 F2 CRP APOH
41 tonsillitis 30.5 TNF IL6 CXCL8
42 mycobacterium chelonae 30.5 TLR2 CXCL8
43 pyuria 30.5 CXCL8 CRP ALB
44 lymphadenitis 30.5 TNF IL10 CXCL8
45 acute respiratory distress syndrome 30.5 TNF IL6 CXCL8
46 aseptic meningitis 30.5 TNF IL10 CXCL8
47 pleurisy 30.4 TNF CXCL8 CRP
48 disseminated intravascular coagulation 30.4 SERPINC1 PLAT PIK3C2A F2
49 liver disease 30.4 TNF IL6 F2 ALB
50 alcoholic liver cirrhosis 30.4 F2 CXCL8 ALB

Graphical network of the top 20 diseases related to Endocarditis:



Diseases related to Endocarditis

Symptoms & Phenotypes for Endocarditis

UMLS symptoms related to Endocarditis:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Endocarditis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ALB CXCL8 FCGR2A HSPD1 PIK3C2A SERPINC1

MGI Mouse Phenotypes related to Endocarditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.17 ALB APOH AQP9 CRP F2 IL10
2 hematopoietic system MP:0005397 10.15 AQP9 F2 FCGR2A IL10 IL6 LBP
3 cardiovascular system MP:0005385 10.14 CRP F2 IL10 IL6 PIK3C2A PLAT
4 immune system MP:0005387 10.07 AQP9 CRP F2 FCGR2A IL10 IL6
5 mortality/aging MP:0010768 9.8 ALB APOH F2 FCGR2A HSPD1 IL10
6 liver/biliary system MP:0005370 9.7 ALB IL10 IL6 LBP SERPINC1 TLR2
7 muscle MP:0005369 9.23 ALB HSPD1 IL10 IL6 PLAT TLR2

Drugs & Therapeutics for Endocarditis

PubMed Health treatment related to Endocarditis: 63

Infective endocarditis (IE) is treated with antibiotics and sometimes with heart surgery.

Drugs for Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 266)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
4
Aminocaproic acid Approved, Investigational Phase 4 60-32-2 564
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6
Acetaminophen Approved Phase 4 103-90-2 1983
7
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
8
Clarithromycin Approved Phase 4 81103-11-9 84029
9
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
10
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
11
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
12
Hexetidine Approved, Investigational Phase 4 141-94-6
13
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
14
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
15
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
16
Norepinephrine Approved Phase 4 51-41-2 439260
17
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
18
Racepinephrine Approved Phase 4 329-65-7 838
19
Dobutamine Approved Phase 4 34368-04-2 36811
20
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
21
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
22
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
23
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
24
Oritavancin Approved, Investigational Phase 4 171099-57-3 16129632
25
Fosfomycin Approved Phase 4 23155-02-4 446987
26
Cloxacillin Approved, Investigational, Vet_approved Phase 4 61-72-3 6098
27
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
28
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
29
Cephalexin Approved, Investigational, Vet_approved Phase 4 15686-71-2 27447
30
Vancomycin Approved Phase 4 1404-90-6 441141 14969
31
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
32
Ceftaroline fosamil Approved, Investigational Phase 4 229016-73-3
33
Linezolid Approved, Investigational Phase 4 165800-03-3 441401
34
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
35
Posaconazole Approved, Investigational, Vet_approved Phase 4 171228-49-2 147912
36
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
37 Simendan Investigational Phase 4 131741-08-7
38 Hemostatics Phase 4
39 Coagulants Phase 4
40 Analgesics Phase 4
41 Analgesics, Non-Narcotic Phase 4
42 Antiviral Agents Phase 4
43 Antineoplastic Agents, Hormonal Phase 4
44 Anticoagulants Phase 4
45 Prednisolone acetate Phase 4
46 Neuroprotective Agents Phase 4
47 glucocorticoids Phase 4
48 Antifibrinolytic Agents Phase 4
49 Methylprednisolone Acetate Phase 4
50 Anti-Inflammatory Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 218)
# Name Status NCT ID Phase Drugs
1 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Unknown status NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
2 Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study: a Multicenter, Prospective, Randomized Trial Comparing the State-of-the-Art Therapeutic Strategy Versus Early Surgery Strategy in Infective Endocarditis Unknown status NCT00624091 Phase 4
3 Pharmacokinetics/ Pharmacodynamics (PK/PD) Study of Vancomycin in the Treatment of Methicillin-resistant Staphylococcus Aureus(MRSA) Blood Stream Infection (Septicemia) and Endocarditis in Chinese Patients Unknown status NCT02443064 Phase 4 Vancomycin
4 Randomized Clinical Trial to Verify the Effectiveness of Topical Aminocaproic Acid in the Prevention of Post-exodontic Bleeding in Patients on Anticoagulants Unknown status NCT02238288 Phase 4 Aminocaproic acid;lidocaine and epinephrine;Paracetamol
5 Comparison of the Efficacy of Triple Therapy With or Without Acetylcysteine in the First Line of Helicobacter Pylori Infection- A Multicenter Randomized Comparative Trial Unknown status NCT02249546 Phase 4 N-acetylcysteine + PPI-amoxicillin-clarithromycin;PPI-amoxicillin-clarithromycin
6 The Effect of 6-Methyl-Prednisolone on Organ Dysfunction and Mortality of Patients With Unresolving Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4 6-methyl-prednisolone
7 Evaluation of the Efficacy and Safety of Fosfomycin Plus Imipenem for the Treatment of Methicillin-resistant Staphylococcus Aureus (MRSA) Infective Endocarditis. Completed NCT00871104 Phase 4 Fosfomycin and imipenem;Vancomycin
8 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Completed NCT01920126 Phase 4 sodium bicarbonate;Saline
9 Partial Oral Treatment of Endocarditis Completed NCT01375257 Phase 4 Oral treatment with antibiotics for endocarditis;Guideline treatment with parenteral antibiotics
10 A Randomized Comparison of Early Surgery Versus Conventional Treatment Strategy in Patients With High Embolic Risk of Infective Endocarditis Completed NCT00750373 Phase 4
11 Health Economic Evaluation of Rapid Detection of Bacteraemia and Fungemia by Real Time PCR for Cases of Febrile Neutropenia, Suspicion of Endocarditis and Severe Sepsis in Intensive Care Units Completed NCT00709358 Phase 4
12 A Comparative Evaluation of the Safety and Efficacy of Daptomycin Versus Standard of Care in Pediatric Subjects One - Seventeen Years of Age With Bacteremia Caused by Staphylococcus Aureus. Completed NCT01728376 Phase 4 Daptomycin;Comparator
13 Influence of Pre-procedural Oral Rinse in the Induced Bacteremia by Periodontal Instrumentation: a Randomized Clinical Trial Completed NCT02215473 Phase 4 Chlorhexidine gluconate mouth rinse
14 The Use of Antifungal Lock Therapy in Intestinal Failure and Other Patients Completed NCT00936910 Phase 4 amphotericin B liposomal (Ambisome)
15 The Effects of Levosimendan on Renal Function in Patients With Low Ejection Fraction Undergoing Mitral Valve Surgery. Completed NCT01969071 Phase 4 Levosimendan;Dobutamine
16 Comparative Study of Hemodynamic Changes Caused by Diazepam and Midazolam During Third Molar Surgery. A Prospective Randomized Study Completed NCT02177955 Phase 4 7.5 mg Midazolam;10 mg diazepam
17 Bacteraemia Secondary to Tooth Extraction: a Randomized Clinical Trial on Efficacy of Three Different Chlorhexidine Prophylaxis Protocols Completed NCT02150031 Phase 4 0.2% Chlorhexidine;1% Chlorhexidine;1% Chlorhexidine;Lidocaine plus adrenaline
18 Does Whole Blood Adsorber During CPB Reduce the Amount of Vasoactive Drugs Postoperatively in Endocarditis Patients Undergoing Valve Surgery? -a Randomized Controlled Study Recruiting NCT03945708 Phase 4
19 An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Recruiting NCT02783404 Phase 4 Amoxicillin;Amoxicillin-Potassium Clavulanate
20 A Pilot Proof of Concept Single-Center Study of the Use of Oritavancin in Systemic Staphylococcus Aureus Infections in Patients With Opioid Use Disorder Recruiting NCT03761953 Phase 4 Oritavancin Injection
21 People Who Inject Drugs; Longitudinal Staphylococcus Aureus Colonization Pattern and the Impact on Infection Frequency by Regular Showers With Chlorhexidine Active, not recruiting NCT03940729 Phase 4 Chlorhexidine Topical
22 Multicenter, Randomised, Open-label Phase III-IV Study to Evaluate the Efficacy of Cloxacillin and Fosfomycin Combination Versus Cloxacillin Monotherapy in Adult Patients With Methicillin-susceptible Staphylococcus Aureus Bacteraemia: the SAFO Trial. Not yet recruiting NCT03959345 Phase 4 Combination therapy group;Standard therapy group
23 Impact of Antibiotic Treatment Following Implantation of Cardiac Electronic Device on Patient's Outcome Not yet recruiting NCT03148444 Phase 4 cefalexin 500 mg qid or roxithromycin 150 mg bid
24 Pilot Randomised Controlled Trial of Penicillin Versus Flucloxacillin for Definitive Treatment of Invasive Penicillin Susceptible Staphylococcus Aureus Not yet recruiting NCT03632642 Phase 4 Benzylpenicillin;Flucloxacillin
25 Open Label Study to Assess the Efficacy and Safety of Daptomycin in Combination With Anti-Cell Wall Active Therapy in the Treatment of Enterococcal Endocarditis Terminated NCT00401960 Phase 4 Daptomycin
26 A Phase 4 Multicenter, Randomized, Double Blind Study to Describe the Efficacy and Safety of Cubicin® (Daptomycin for Injection) With and Without Initial Gentamicin Combination Therapy in the Treatment of S. Aureus Infective Endocarditis Terminated NCT00638157 Phase 4 daptomycin;daptomycin and gentamicin
27 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
28 The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study Terminated NCT00164099 Phase 4 Synbiotic 2000
29 Open Label, Limited Access Protocol of Posaconazole in Invasive Fungal Infections Study PO2095 Terminated NCT00177749 Phase 4 Posaconazole
30 Perceval S Valve Clinical Trial for Extended CE Mark Unknown status NCT01368666 Phase 2, Phase 3
31 Randomized Controlled Trial Comparing Long and Short Duration of Antibiotic Prophylaxis for Patients Undergoing Sinus Lift Surgery Unknown status NCT02764710 Phase 3 Amoxicillin-Potassium Clavulanate Combination
32 "Salvage Use" of Recombinant Activated Factor VII After Inadequate Haemostatic Response to Conventional Therapy in Complex Cardiac Surgery - a Randomised Placebo Controlled Trial Unknown status NCT00214656 Phase 3 Recombinant Activated Factor VII
33 A Phase 3, Multicenter, Randomized, Open-Label, Comparative Study to Assess the Safety and Efficacy of Daptomycin Compared to Conventional Therapy In the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to Staph Aureus Completed NCT00093067 Phase 3 daptomycin
34 A Phase III Randomized, Open-labeled Clinical Trial of MK-3009 (Daptomycin) in Patients With Skin and Soft Tissue Infections, Septicemia and Right-sided Infective Endocarditis Caused by MRSA Completed NCT00770341 Phase 3 Daptomycin 4 mg/kg;Comparator: vancomycin;Daptomycin 6 mg/kg
35 Population Pharmacokinetic (PK) Study of Multiple Doses of Cubicin® (Daptomycin) 10 mg/kg in Critical Care Patients Having Bacteremia, Endocarditis or Skin Soft Tissue Infections Due to Gram Positive Bacteria With Various Degrees of Renal Failure Completed NCT02142075 Phase 3 Daptomycin
36 A Multicenter, Randomized, Double-Blinded Comparative Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Daptomycin Versus Active Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis Due to Gram-Positive Organisms Completed NCT01922011 Phase 3 Daptomycin;Vancomycin (or equivalent);Nafcillin (or equivalent)
37 Conservative Aortic Valve Surgery for Aortic Insufficiency and Aneurysms of the Aortic Root Completed NCT00478803 Phase 3
38 Health Promotion and Public Safety: Community-based Collaborative Services to Addicted Offenders Completed NCT01843751 Phase 3 buprenorphine/naloxone
39 Treatment With Cotrimoxazole vs. Vancomycin for Infections Caused by Methicillin-resistant Staphylococcus Aureus: Randomized Controlled Trial Completed NCT00427076 Phase 3 Cotrimoxazole;Vancomycin
40 A Randomized, Double-blind, Multi-center Study to Establish the Efficacy and Safety of Ceftobiprole Medocaril Compared to Daptomycin in the Treatment of Staphylococcus Aureus Bacteremia, Including Infective Endocarditis Recruiting NCT03138733 Phase 3 Ceftobiprole medocaril;Daptomycin
41 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus (Relais Oral Dans le Traitement Des Endocardites à Staphylocoques Multi-sensibles) Recruiting NCT02701608 Phase 3 Levofloxacin;Rifampicin
42 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus (Relais Oral Dans le Traitement Des Endocardites à Streptocoques Multi-sensibles) Recruiting NCT02701595 Phase 3 Amoxicillin
43 Early Oral Switch Therapy in Low-risk Staphylococcus Aureus Bloodstream Infection Recruiting NCT01792804 Phase 3 Trimethoprim-Sulfamethoxazole;Clindamycin;Linezolid;Flucloxacillin;Cloxacillin;Vancomycin;Daptomycin;Cefazolin
44 Role of (LMWH) in Prevention of Thromboembolic Complication After (TACE) in Hepatocellular Carcinoma. Not yet recruiting NCT02715492 Phase 3 LMWH
45 Effect of Rituximab in Treatment of Primary Membranoproliferative Glomerulonephritis Not yet recruiting NCT03180723 Phase 3 Rituximab;Cyclosporin
46 A Phase 3 Multicenter, Randomized, Open-label, Clinical Trial of Telavancin Versus Standard Intravenous Therapy in the Treatment of Subjects With Staphylococcus Aureus Bacteremia Including Infective Endocarditis Terminated NCT02208063 Phase 3 Telavancin;Vancomycin;Daptomycin;Synthetic penicillin;Cefazolin
47 A Randomized Study of the Effects of Perioperative i.v. Ketorolac-lidocaine on the Hemodynamic Response in the Patients With Valvular Heart Diseases During Cesarean Delivery Unknown status NCT01571791 Phase 2 Placebo;Ketorolac-Lidocaine
48 A Multicenter, Double-Blind, Randomized, Comparative Study of the Safety, Tolerability, Efficacy, and Pharmacokinetics of CF-301 vs. Placebo in Addition to Standard-of-Care Antibacterial Therapy for the Treatment of Adult Patients With Staphylococcus Aureus Bloodstream Infections (Bacteremia) Including Endocarditis Completed NCT03163446 Phase 2 Placebo
49 Initial Safety and Pharmacokinetics Trial of Immune Globulin to Staphylococcus Aureus Capsule Polysaccharide (Altastaph) in Subjects With S. Aureus Bacteremia and Persistent Fever Completed NCT00063089 Phase 1, Phase 2 S. aureus Immune Globulin Intravenous (Human) 5%
50 Continued Evaluation of the Safety of Q Fever Vaccine, Phase I, Inactivated, Freeze Dried, NDBR 105, in Those at Risk of Exposure to Coxiella Burnetii, A Phase 2 Study Completed NCT00584454 Phase 2

Search NIH Clinical Center for Endocarditis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Ampicillin
Benzylpenicillin
Cefazolin
Cloxacillin
GENTAMICIN SULFATE PWDR

Cochrane evidence based reviews: endocarditis

Genetic Tests for Endocarditis

Anatomical Context for Endocarditis

MalaCards organs/tissues related to Endocarditis:

41
Heart, Colon, Brain, Skin, Testes, Liver, Lung

Publications for Endocarditis

Articles related to Endocarditis:

(show top 50) (show all 30003)
# Title Authors PMID Year
1
Case report: right-sided native endocarditis presenting with multiple abscess formations [care compliant]. 38 17
31192934 2019
2
Nonbacterial Thrombotic Endocarditis. 38 17
31216402 2019
3
Listen to Your Heart. 17
31087026 2019
4
Fibronectin-binding proteins and clumping factor A in Staphylococcus aureus experimental endocarditis: FnBPA is sufficient to activate human endothelial cells. 9 38
17393025 2007
5
Safety evaluation of Lactobacillus delbrueckii subsp. lactis UO 004, a probiotic bacterium. 9 38
15748979 2005
6
Bartonella koehlerae, a new cat-associated agent of culture-negative human endocarditis. 9 38
15297484 2004
7
Virulence of enterococci. 9 38
7834601 1994
8
Haemophilus parainfluenzae endocarditis in a patient with mitral valve prolapse. 9 38
8323254 1993
9
Activity of ampicillin plus sulbactam against beta-lactamase producing enterococci in experimental endocarditis. 9 38
8444668 1993
10
Killing curve activity of ciprofloxacin is comparable to synergistic effect of beta-lactam-tobramycin combinations against Haemophilus species endocarditis strains. 9 38
1389104 1992
11
Bromide-dependent toxicity of eosinophil peroxidase for endothelium and isolated working rat hearts: a model for eosinophilic endocarditis. 9 38
1985118 1991
12
Efficacy of amoxycillin/clavulanic acid in experimental Staphylococcus aureus endocarditis in the rat. 9 38
2050588 1991
13
A case of infective endocarditis associated with atopic dermatitis perioperatively treated with dupilumab. 38
30628496 2019
14
The role of 18F-FDG PET/CT in early infectious discitis: a case report after a negative MRI. 38
31417664 2019
15
Characterization, epidemiological profile and risk factors for clinical outcome of infective endocarditis from a tertiary care centre in Turkey. 38
31364901 2019
16
Surgical treatment of isolated tricuspid valve infective endocarditis: 25-year results from a multicenter registry. 38
31130281 2019
17
Ceftobripole: Experience in staphylococcal bacteremia. 38
31364338 2019
18
Candida tropicalis defibrillator endocarditis: A case report and review of current literature. 38
31245269 2019
19
A Case of Mitral Valve Endocarditis Complicated by Multiple Embolic Phenomena: Leaping from Adult Guidelines to Pediatric Critical Care Decisions. 38
31404392 2019
20
Clinical characteristics and treatment outcomes of Enterococcus durans bacteremia: a 20-year experience in a tertiary care hospital. 38
31243595 2019
21
Contribution of hla Regulation by SaeR to Staphylococcus aureus USA300 Pathogenesis. 38
31209148 2019
22
MicroRNAs fingerprint of bicuspid aortic valve. 38
31278905 2019
23
Contemporary epidemiology of infective endocarditis in patients with congenital heart disease: A UK prospective study. 38
31299559 2019
24
Does gender affect the prognosis and risk of complications in patients with congenital heart disease in the modern era? 38
31085083 2019
25
Tricuspid valve relocation with endomyocardial fibrosis removal for Löeffler's endocarditis. 38
30753388 2019
26
Portraying infective endocarditis: results of multinational ID-IRI study. 38
31187307 2019
27
Use of mechanical valve prostheses in adults with tetralogy of Fallot. 38
30803889 2019
28
[Febrile myalgia revealing Propionibacterium acnes endocarditis]. 38
31229357 2019
29
Pneumococcal pericarditis, endocarditis, and pneumococcal and tuberculous co-infection are other cardiovascular complications of pneumococcal pneumonia. 38
30968466 2019
30
Escherichia coli endocarditis in an hemodialysis patient. 38
30926110 2019
31
Infectious Endocarditis After Transcatheter Aortic Valve Replacement: Epidemiology and Outcomes. 38
31393286 2019
32
The risk of infective endocarditis following interventional pulmonary valve implantation: A meta-analysis. 38
31113702 2019
33
Ceftaroline as salvage therapy for complicated MRSA bacteremia: case series and analysis. 38
30955166 2019
34
Heyde Syndrome: Aortic Stenosis and Beyond. 38
31230737 2019
35
Retrospective Comparison of the Supported and Unsupported Bovine Jugular Vein Conduit in Children. 38
30974093 2019
36
Association between patient age at implant and outcomes after transcatheter pulmonary valve replacement in the multicenter Melody valve trials. 38
31419019 2019
37
Incidence and outcomes of systemic infections in patients with leadless pacemakers: Data from the Micra IDE study. 38
31232461 2019
38
Vacuum-assisted vegetation removal with percutaneous lead extraction: a systematic review of the literature. 38
31025152 2019
39
Reinterventions after freestyle stentless aortic valve replacement: an assessment of procedural risks. 38
31424504 2019
40
Epidemiology, pathogenesis, treatment and outcomes of infection-associated glomerulonephritis. 38
31399725 2019
41
Mitral Valve Endocarditis: A Rare Manifestation of Lyme Disease. 38
30690018 2019
42
Recurrent lung nodules as a presentation of ventricular septal defect-related endocarditis. 38
31168368 2019
43
Prediction of Acute-phase Complications in Patients with Infectious Endocarditis. 38
31118367 2019
44
Outcome of early vs delayed surgery for infective mitral endocarditis. 38
31269271 2019
45
The utility of inflammatory markers in diagnostic work-up of pacemaker and defibrillator infections in patients referred for transvenous lead extraction. 38
31424054 2019
46
Knowledge of antibiotics and antimicrobial resistance amongst final year dental students of Polish medical schools-A cross-sectional study. 38
30729642 2019
47
Prognosis of Streptococcus pneumoniae endocarditis in France, a multicenter observational study (2000-2015). 38
31056415 2019
48
Endocarditis Caused by Highly Penicillin-Resistant Viridans Group Streptococci: Still Room for Vancomycin-Based Regimens. 38
31182540 2019
49
Daptomycin-containing regimens for treatment of gram-positive endocarditis. 38
31400470 2019
50
Should High-dose Daptomycin be an Alternative Treatment Regimen for Enterococcal Endocarditis? 38
31428940 2019

Variations for Endocarditis

Expression for Endocarditis

Search GEO for disease gene expression data for Endocarditis.

Pathways for Endocarditis

Pathways related to Endocarditis according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 TNF TLR2 LBP IL6 IL10 CXCL8
2
Show member pathways
12.29 TNF TLR2 IL6 CXCL8
3
Show member pathways
12.26 TNF LBP IL6 CXCL8
4
Show member pathways
12.24 TNF PLAT IL6 F2 CRP ALB
5
Show member pathways
12.23 TNF TLR2 IL6 CXCL8
6
Show member pathways
12.22 TNF TLR2 IL10 FCGR2A
7
Show member pathways
12.17 TNF TLR2 IL6 CXCL8
8
Show member pathways
12.14 TNF TLR2 LBP IL6 CXCL8
9 12.12 TNF IL6 IL10 HSPD1 CXCL8
10 12.04 VCAM1 TNNI3 IL6 ALB
11
Show member pathways
12.03 TNF TLR2 IL6 IL10
12 11.98 TNF IL6 FCGR2A CXCL8
13 11.95 TNF TLR2 LBP IL6 IL10 HSPD1
14 11.94 TNF IL6 IL10 FCGR2A CEACAM8
15 11.89 VCAM1 TNF LBP CXCL8
16 11.88 VCAM1 TNF IL6 CXCL8
17 11.84 TNF TLR2 IL6 CXCL8
18 11.81 TNF TLR2 IL6 IL10 CXCL8
19 11.79 VCAM1 TNF LBP IL6 IL10 CXCL8
20
Show member pathways
11.78 LBP IL6 CRP
21 11.76 LBP IL6 CXCL8
22 11.74 TNF IL6 IL10 CXCL8
23 11.7 TNF IL6 IL10
24 11.7 TNF IL6 IL10 FCGR2A
25
Show member pathways
11.64 VCAM1 TNF IL6 CXCL8
26 11.63 TNF IL6 CXCL8
27
Show member pathways
11.6 TNF TLR2 PLAT IL6 HSPD1 FCGR2A
28 11.49 TNF IL6 IL10 CXCL8
29 11.48 TNF PLAT IL6
30 11.47 TNF TLR2 IL6 HSPD1 CXCL8
31 11.33 TNF IL6 IL10
32 11.33 VCAM1 TNF IL6 IL10
33 11.23 TNF IL6 IL10
34 11.16 TNF IL6 IL10 CXCL8
35 10.95 TNF IL6 CXCL8 CRP
36 10.79 VCAM1 TNF TLR2 IL6 IL10 CXCL8

GO Terms for Endocarditis

Cellular components related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.96 VCAM1 SERPINC1 PLAT PIK3C2A LBP HSPD1
2 extracellular region GO:0005576 9.9 TNF SERPINC1 PLAT LBP IL6 IL10
3 cell surface GO:0009986 9.56 VCAM1 TNF TLR2 PLAT LBP HSPD1
4 extracellular space GO:0005615 9.47 VCAM1 TNF SERPINC1 PLAT LBP IL6

Biological processes related to Endocarditis according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.92 SERPINC1 IL6 F2 ALB
2 cellular response to lipopolysaccharide GO:0071222 9.88 TNF LBP IL6 IL10 CXCL8
3 immune response GO:0006955 9.88 TNF TLR2 IL6 IL10 CXCL8 CEACAM8
4 cytokine-mediated signaling pathway GO:0019221 9.85 VCAM1 TNF LBP IL6 IL10 CXCL8
5 response to lipopolysaccharide GO:0032496 9.8 VCAM1 TLR2 LBP IL10
6 response to hypoxia GO:0001666 9.77 VCAM1 TLR2 PLAT
7 lipopolysaccharide-mediated signaling pathway GO:0031663 9.76 TNF TLR2 LBP
8 positive regulation of interleukin-8 production GO:0032757 9.74 TNF TLR2 LBP
9 response to organic substance GO:0010033 9.73 TNF IL10 AQP9
10 positive regulation of macrophage activation GO:0043032 9.71 LBP IL10 HSPD1
11 response to glucocorticoid GO:0051384 9.7 TNF IL6 IL10
12 negative regulation of growth of symbiont in host GO:0044130 9.69 TNF LBP IL10
13 positive regulation of blood coagulation GO:0030194 9.65 F2 APOH
14 plasminogen activation GO:0031639 9.64 PLAT APOH
15 positive regulation of inflammatory response GO:0050729 9.64 TNF TLR2
16 negative regulation of fibrinolysis GO:0051918 9.63 F2 APOH
17 cellular response to lipoteichoic acid GO:0071223 9.63 TLR2 LBP
18 regulation of blood coagulation GO:0030193 9.63 SERPINC1 F2 APOH
19 opsonization GO:0008228 9.62 LBP CRP
20 endothelial cell apoptotic process GO:0072577 9.61 TNF IL10
21 positive regulation of neuroinflammatory response GO:0150078 9.61 TNF IL6
22 response to molecule of bacterial origin GO:0002237 9.61 TLR2 IL10 CXCL8
23 negative regulation of cytokine secretion involved in immune response GO:0002740 9.6 TNF IL10
24 receptor biosynthetic process GO:0032800 9.58 TNF IL10
25 acute-phase response GO:0006953 9.56 LBP IL6 F2 CRP
26 defense response to Gram-positive bacterium GO:0050830 9.55 TNF TLR2 LBP IL6 CRP
27 negative regulation of lipid storage GO:0010888 9.5 TNF IL6 CRP
28 positive regulation of chemokine production GO:0032722 9.26 TNF TLR2 LBP IL6
29 positive regulation of interleukin-6 production GO:0032755 9.02 TNF TLR2 LBP IL6 HSPD1
30 inflammatory response GO:0006954 10.02 TNF TLR2 IL6 IL10 CXCL8 CRP

Molecular functions related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 TNF TLR2 SERPINC1 LACTB CRP APOH
2 cytokine activity GO:0005125 9.46 TNF IL6 IL10 CXCL8
3 lipopeptide binding GO:0071723 9.26 TLR2 LBP
4 lipopolysaccharide binding GO:0001530 8.92 TLR2 LBP HSPD1 F2

Sources for Endocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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