MCID: END033
MIFTS: 57

Endocarditis

Categories: Blood diseases, Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Endocarditis

MalaCards integrated aliases for Endocarditis:

Name: Endocarditis 12 74 54 42 43 15 62 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10314
ICD9CM 34 421.9
MeSH 43 D004696
SNOMED-CT 67 56819008 91357005
ICD10 32 I33.9
UMLS 71 C0014118 C0375268

Summaries for Endocarditis

MedlinePlus : 42 Endocarditis, also called infective endocarditis (IE), is an inflammation of the inner lining of the heart. The most common type, bacterial endocarditis, occurs when germs enter your heart. These germs come through your bloodstream from another part of your body, often your mouth. Bacterial endocarditis can damage your heart valves. If untreated, it can be life-threatening. It is rare in healthy hearts. Risk factors include having An abnormal or damaged heart valve An artificial heart valve Congenital heart defects The signs and symptoms of IE can vary from person to person. They also can vary over time in the same person. Symptoms you might notice include fever, shortness of breath, fluid buildup in your arms or legs, tiny red spots on your skin, and weight loss. Your doctor will diagnose IE based on your risk factors, medical history, signs and symptoms, and lab and heart tests. Early treatment can help you avoid complications. Treatment usually involves high-dose antibiotics. If your heart valve is damaged, you may need surgery. If you're at risk for IE, brush and floss your teeth regularly, and have regular dental checkups. Germs from a gum infection can enter your bloodstream. If you are at high risk, your doctor might prescribe antibiotics before dental work and certain types of surgery. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Endocarditis is related to marantic endocarditis and infective endocarditis, and has symptoms including edema, chest pain and angina pectoris. An important gene associated with Endocarditis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Allograft rejection. The drugs Cephalexin and Aminocaproic acid have been mentioned in the context of this disorder. Affiliated tissues include heart, colon and skin, and related phenotypes are cardiovascular system and hematopoietic system

Disease Ontology : 12 A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves.

PubMed Health : 62 About endocarditis: Endocarditis (EN-do-kar-DI-tis) is an infection of the inner lining of the heart chambers and valves. This lining is called the endocardium (en-do-KAR-de-um). The condition also is called infective endocarditis (IE). The term "endocarditis" also is used to describe an inflammation of the endocardium due to other conditions. This article only discusses endocarditis related to infection. IE occurs if bacteria, fungi, or other germs invade your bloodstream and attach to abnormal areas of your heart. The infection can damage your heart and cause serious and sometimes fatal complications. IE can develop quickly or slowly; it depends on what type of germ is causing it and whether you have an underlying heart problem. When IE develops quickly, it's called acute infective endocarditis. When it develops slowly, it's called subacute infective endocarditis.

Wikipedia : 74 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

Related Diseases for Endocarditis

Diseases in the Endocarditis family:

Subacute Bacterial Endocarditis

Diseases related to Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1413)
# Related Disease Score Top Affiliating Genes
1 marantic endocarditis 35.0 SERPINC1 F2 CRP APOH
2 infective endocarditis 34.3 TNNI3 TNF TLR6 TLR2 LBP IL6
3 brucellosis 32.9 TNF IL6 IL10 CXCL8 CRP CAT
4 mitral valve disease 32.2 TNNI3 IL10 F2 CRP
5 aortic valve insufficiency 32.2 TNNI3 CRP ALB
6 mitral valve insufficiency 32.0 TNNI3 PIK3C2A F2 CRP ALB
7 tricuspid valve disease 32.0 TNNI3 F2 CRP ALB
8 q fever 32.0 TNF TLR2 IL6 IL10
9 rheumatic heart disease 31.9 TNF TLR2 IL6 IL10
10 congestive heart failure 31.9 TNNI3 TNF PIK3C2A IL6 CRP ALB
11 tricuspid valve insufficiency 31.8 TNNI3 F2 CRP ALB
12 heart valve disease 31.8 TNNI3 F2 CRP APOH ALB
13 intracranial embolism 31.7 SERPINC1 F2 CRP ALB
14 cardiogenic shock 31.6 PIK3C2A CRP
15 rheumatic fever 31.6 TNF TLR2 IL6 IL10 ALB
16 mitral valve stenosis 31.6 SERPINC1 F2 CRP
17 splenic abscess 31.5 LACTB F2 CRP ALB
18 osteomyelitis 31.5 TNF TLR2 IL6 IL10 CXCL8
19 acute kidney failure 31.5 PIK3C2A F2 CAT ALB
20 aortitis 31.5 TNF IL6 CRP
21 antiphospholipid syndrome 31.5 TNF SERPINC1 F2 CRP APOH
22 vasculitis 31.5 TNF IL6 IL10 HSPD1 CRP APOH
23 myocarditis 31.4 TNNI3 TNF PIK3C2A IL6 IL10
24 end stage renal disease 31.4 TNF IL6 CRP ALB
25 haemophilus influenzae 31.4 TNF TLR2 LACTB CXCL8
26 atrial heart septal defect 31.4 TNNI3 SERPINC1 F2 CRP ALB
27 septic arthritis 31.4 TNF TLR2 IL6 CXCL8 CRP
28 endomyocardial fibrosis 31.3 TNF IL10 EPX
29 splenic infarction 31.3 SERPINC1 F2 CRP APOH ALB
30 pulmonary embolism 31.3 TNNI3 SERPINC1 GP1BA F2 CRP APOH
31 spondylitis 31.3 TNF IL6 IL10 CRP
32 mediastinitis 31.3 LACTB F2 CRP ALB
33 pericarditis 31.3 TNNI3 TNF PIK3C2A IL6 CXCL8 CRP
34 liver cirrhosis 31.2 TLR2 SERPINC1 LBP F2 ALB
35 endophthalmitis 31.2 TNF TLR2 IL6 CXCL8 CRP ALB
36 cellulitis 31.2 TNF IL6 IL10 CRP
37 epidural abscess 31.2 F2 CRP ALB
38 pleural empyema 31.2 F2 CRP ALB
39 mycobacterium fortuitum 31.2 LACTB HSPD1 CXCL8
40 pericardial effusion 31.2 TNNI3 PIK3C2A IL6 F2 CRP ALB
41 cardiac tamponade 31.1 TNNI3 PIK3C2A F2 CRP ALB
42 disseminated intravascular coagulation 31.1 TNF SERPINC1 PIK3C2A IL6 IL10 F2
43 toxic shock syndrome 31.1 TNF TLR2 SERPINC1 LBP IL6 IL10
44 dermatitis 31.1 TNF IL6 IL10 CXCL8
45 limb ischemia 31.1 TNNI3 TNF IL6 F2
46 cryoglobulinemia 31.1 TNF IL6 IL10 APOH
47 thrombosis 31.0 SERPINC1 GP1BA F2 APOH
48 branch retinal artery occlusion 31.0 SERPINC1 F2 CRP
49 thrombophilia due to thrombin defect 31.0 SERPINC1 F2 APOH
50 acquired immunodeficiency syndrome 31.0 TNF IL6 IL10 CRP ALB

Graphical network of the top 20 diseases related to Endocarditis:



Diseases related to Endocarditis

Symptoms & Phenotypes for Endocarditis

UMLS symptoms related to Endocarditis:


edema, chest pain, angina pectoris

MGI Mouse Phenotypes related to Endocarditis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.07 ADSL ALB CRP F2 HSPD1 IL10
2 hematopoietic system MP:0005397 9.93 EPX F2 GP1BA HSPD1 IL10 IL6
3 homeostasis/metabolism MP:0005376 9.83 ALB APOH CAT CRP EPX F2
4 immune system MP:0005387 9.4 ALB CRP EPX F2 IL10 IL6

Drugs & Therapeutics for Endocarditis

PubMed Health treatment related to Endocarditis: 62

Infective endocarditis (IE) is treated with antibiotics and sometimes with heart surgery .

Drugs for Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 260)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cephalexin Approved, Investigational, Vet_approved Phase 4 15686-71-2 27447
2
Aminocaproic acid Approved, Investigational Phase 4 60-32-2 564
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
5
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
6 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
7
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
8
Acetaminophen Approved Phase 4 103-90-2 1983
9
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
10
Clarithromycin Approved Phase 4 81103-11-9 84029
11
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
12
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
13
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
14
Hexetidine Approved, Investigational Phase 4 141-94-6
15
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
16
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
17
Amphotericin B Approved, Investigational Phase 4 1397-89-3 5280965 14956
18
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
19
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
20
Racepinephrine Approved Phase 4 329-65-7 838
21
Norepinephrine Approved Phase 4 51-41-2 439260
22
Dobutamine Approved Phase 4 34368-04-2 36811
23
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
24
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
25
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
26
Oritavancin Approved, Investigational Phase 4 171099-57-3 16129632
27
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
28
Fosfomycin Approved Phase 4 23155-02-4 446987
29
Cloxacillin Approved, Investigational, Vet_approved Phase 4 61-72-3 6098
30
tannic acid Approved Phase 4 1401-55-4
31
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
32
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
33
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
34
Vancomycin Approved Phase 4 1404-90-6 14969 441141
35
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
36
Ceftaroline fosamil Approved, Investigational Phase 4 229016-73-3
37
Linezolid Approved, Investigational Phase 4 165800-03-3 441401
38
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
39
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
40
Posaconazole Approved, Investigational, Vet_approved Phase 4 171228-49-2 147912
41
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
42
Simendan Investigational Phase 4 131741-08-7
43 Hemostatics Phase 4
44 Lactams Phase 4
45 beta-Lactams Phase 4
46 Analgesics, Non-Narcotic Phase 4
47 Anticoagulants Phase 4
48 Methylprednisolone Acetate Phase 4
49 Antiviral Agents Phase 4
50 Neuroprotective Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 242)
# Name Status NCT ID Phase Drugs
1 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Unknown status NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
2 Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study: a Multicenter, Prospective, Randomized Trial Comparing the State-of-the-Art Therapeutic Strategy Versus Early Surgery Strategy in Infective Endocarditis Unknown status NCT00624091 Phase 4
3 Pharmacokinetics/ Pharmacodynamics (PK/PD) Study of Vancomycin in the Treatment of Methicillin-resistant Staphylococcus Aureus(MRSA) Blood Stream Infection (Septicemia) and Endocarditis in Chinese Patients Unknown status NCT02443064 Phase 4 Vancomycin
4 Randomized Clinical Trial to Verify the Effectiveness of Topical Aminocaproic Acid in the Prevention of Post-exodontic Bleeding in Patients on Anticoagulants Unknown status NCT02238288 Phase 4 Aminocaproic acid;lidocaine and epinephrine;Paracetamol
5 Impact of Antibiotic Treatment Following Implantation of Cardiac Electronic Device on Patient's Outcome Unknown status NCT03148444 Phase 4 cefalexin 500 mg qid or roxithromycin 150 mg bid
6 Comparison of the Efficacy of Triple Therapy With or Without Acetylcysteine in the First Line of Helicobacter Pylori Infection- A Multicenter Randomized Comparative Trial Unknown status NCT02249546 Phase 4 N-acetylcysteine + PPI-amoxicillin-clarithromycin;PPI-amoxicillin-clarithromycin
7 The Effect of 6-Methyl-Prednisolone on Organ Dysfunction and Mortality of Patients With Unresolving Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4 6-methyl-prednisolone
8 Evaluation of the Efficacy and Safety of Fosfomycin Plus Imipenem for the Treatment of Methicillin-resistant Staphylococcus Aureus (MRSA) Infective Endocarditis. Completed NCT00871104 Phase 4 Fosfomycin and imipenem;Vancomycin
9 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Completed NCT01920126 Phase 4 sodium bicarbonate;Saline
10 Partial Oral Treatment of Endocarditis Completed NCT01375257 Phase 4 Oral treatment with antibiotics for endocarditis;Guideline treatment with parenteral antibiotics
11 A Randomized Comparison of Early Surgery Versus Conventional Treatment Strategy in Patients With High Embolic Risk of Infective Endocarditis Completed NCT00750373 Phase 4
12 Health Economic Evaluation of Rapid Detection of Bacteraemia and Fungemia by Real Time PCR for Cases of Febrile Neutropenia, Suspicion of Endocarditis and Severe Sepsis in Intensive Care Units Completed NCT00709358 Phase 4
13 Influence of Pre-procedural Oral Rinse in the Induced Bacteremia by Periodontal Instrumentation: a Randomized Clinical Trial Completed NCT02215473 Phase 4 Chlorhexidine gluconate mouth rinse
14 A Comparative Evaluation of the Safety and Efficacy of Daptomycin Versus Standard of Care in Pediatric Subjects One - Seventeen Years of Age With Bacteremia Caused by Staphylococcus Aureus. Completed NCT01728376 Phase 4 Daptomycin;Comparator
15 The Use of Antifungal Lock Therapy in Intestinal Failure and Other Patients Completed NCT00936910 Phase 4 amphotericin B liposomal (Ambisome)
16 The Effects of Levosimendan on Renal Function in Patients With Low Ejection Fraction Undergoing Mitral Valve Surgery. Completed NCT01969071 Phase 4 Levosimendan;Dobutamine
17 Comparative Study of Hemodynamic Changes Caused by Diazepam and Midazolam During Third Molar Surgery. A Prospective Randomized Study Completed NCT02177955 Phase 4 7.5 mg Midazolam;10 mg diazepam
18 Bacteraemia Secondary to Tooth Extraction: a Randomized Clinical Trial on Efficacy of Three Different Chlorhexidine Prophylaxis Protocols Completed NCT02150031 Phase 4 0.2% Chlorhexidine;1% Chlorhexidine;1% Chlorhexidine;Lidocaine plus adrenaline
19 An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Recruiting NCT02783404 Phase 4 Amoxicillin;Amoxicillin-Potassium Clavulanate
20 A Pilot Proof of Concept Single-Center Study of the Use of Oritavancin in Systemic Staphylococcus Aureus Infections in Patients With Opioid Use Disorder Recruiting NCT03761953 Phase 4 Oritavancin Injection
21 Plasma Concentrations of Amoxicillin Administered in High-doses During the First Week of Treatment : Intra- and Inter-individual Variability, Factors Associated With Overdose and Adverse Events Recruiting NCT04070469 Phase 4 Amoxicillin
22 People Who Inject Drugs; Longitudinal Staphylococcus Aureus Colonization Pattern and the Impact on Infection Frequency by Regular Showers With Chlorhexidine Active, not recruiting NCT03940729 Phase 4 Chlorhexidine Topical
23 Short-course Antibiotic Regimen Compared to Conventional Antibiotic Treatment for Gram-positive Cocci Infective Endocarditis: Randomized Clinical Trial Not yet recruiting NCT04222257 Phase 4 Antibiotics;Antibiotics
24 Multicenter, Randomised, Open-label Phase III-IV Study to Evaluate the Efficacy of Cloxacillin and Fosfomycin Combination Versus Cloxacillin Monotherapy in Adult Patients With Methicillin-susceptible Staphylococcus Aureus Bacteraemia: the SAFO Trial. Not yet recruiting NCT03959345 Phase 4 Combination therapy group;Standard therapy group
25 Pilot Randomised Controlled Trial of Penicillin Versus Flucloxacillin for Definitive Treatment of Invasive Penicillin Susceptible Staphylococcus Aureus Not yet recruiting NCT03632642 Phase 4 Benzylpenicillin;Flucloxacillin
26 Open Label Study to Assess the Efficacy and Safety of Daptomycin in Combination With Anti-Cell Wall Active Therapy in the Treatment of Enterococcal Endocarditis Terminated NCT00401960 Phase 4 Daptomycin
27 A Phase 4 Multicenter, Randomized, Double Blind Study to Describe the Efficacy and Safety of Cubicin® (Daptomycin for Injection) With and Without Initial Gentamicin Combination Therapy in the Treatment of S. Aureus Infective Endocarditis Terminated NCT00638157 Phase 4 daptomycin;daptomycin and gentamicin
28 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
29 The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study Terminated NCT00164099 Phase 4 Synbiotic 2000
30 Open Label, Limited Access Protocol of Posaconazole in Invasive Fungal Infections Study PO2095 Terminated NCT00177749 Phase 4 Posaconazole
31 Effect of Rituximab in Treatment of Primary Membranoproliferative Glomerulonephritis Unknown status NCT03180723 Phase 3 Rituximab;Cyclosporin
32 Perceval S Valve Clinical Trial for Extended CE Mark Unknown status NCT01368666 Phase 2, Phase 3
33 Randomized Controlled Trial Comparing Long and Short Duration of Antibiotic Prophylaxis for Patients Undergoing Sinus Lift Surgery Unknown status NCT02764710 Phase 3 Amoxicillin-Potassium Clavulanate Combination
34 "Salvage Use" of Recombinant Activated Factor VII After Inadequate Haemostatic Response to Conventional Therapy in Complex Cardiac Surgery - a Randomised Placebo Controlled Trial Unknown status NCT00214656 Phase 3 Recombinant Activated Factor VII
35 A Phase 3, Multicenter, Randomized, Open-Label, Comparative Study to Assess the Safety and Efficacy of Daptomycin Compared to Conventional Therapy In the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to Staph Aureus Completed NCT00093067 Phase 3 daptomycin
36 A Phase III Randomized, Open-labeled Clinical Trial of MK-3009 (Daptomycin) in Patients With Skin and Soft Tissue Infections, Septicemia and Right-sided Infective Endocarditis Caused by MRSA Completed NCT00770341 Phase 3 Daptomycin 4 mg/kg;Comparator: vancomycin;Daptomycin 6 mg/kg
37 Early Oral Switch Therapy in Low-risk Staphylococcus Aureus Bloodstream Infection Completed NCT01792804 Phase 3 Trimethoprim-Sulfamethoxazole;Clindamycin;Linezolid;Flucloxacillin;Cloxacillin;Vancomycin;Daptomycin;Cefazolin
38 Population Pharmacokinetic (PK) Study of Multiple Doses of Cubicin® (Daptomycin) 10 mg/kg in Critical Care Patients Having Bacteremia, Endocarditis or Skin Soft Tissue Infections Due to Gram Positive Bacteria With Various Degrees of Renal Failure Completed NCT02142075 Phase 3 Daptomycin
39 A Multicenter, Randomized, Double-Blinded Comparative Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Daptomycin Versus Active Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis Due to Gram-Positive Organisms Completed NCT01922011 Phase 3 Daptomycin;Vancomycin (or equivalent);Nafcillin (or equivalent)
40 Conservative Aortic Valve Surgery for Aortic Insufficiency and Aneurysms of the Aortic Root Completed NCT00478803 Phase 3
41 Health Promotion and Public Safety: Community-based Collaborative Services to Addicted Offenders Completed NCT01843751 Phase 3 buprenorphine/naloxone
42 Treatment With Cotrimoxazole vs. Vancomycin for Infections Caused by Methicillin-resistant Staphylococcus Aureus: Randomized Controlled Trial Completed NCT00427076 Phase 3 Cotrimoxazole;Vancomycin
43 A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of a Single Dose of Exebacase in Patients Receiving Standard-of-Care Antibiotics for the Treatment of Staphylococcus Aureus Bloodstream Infections (Bacteremia), Including Right-Sided Infective Endocarditis Recruiting NCT04160468 Phase 3 Exebacase;Placebo
44 A Randomized, Double-blind, Multi-center Study to Establish the Efficacy and Safety of Ceftobiprole Medocaril Compared to Daptomycin in the Treatment of Staphylococcus Aureus Bacteremia, Including Infective Endocarditis Recruiting NCT03138733 Phase 3 Ceftobiprole medocaril;Daptomycin
45 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus (Relais Oral Dans le Traitement Des Endocardites à Staphylocoques Multi-sensibles) Recruiting NCT02701608 Phase 3 Levofloxacin;Rifampicin
46 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus (Relais Oral Dans le Traitement Des Endocardites à Streptocoques Multi-sensibles) Recruiting NCT02701595 Phase 3 Amoxicillin
47 Role of (LMWH) in Prevention of Thromboembolic Complication After (TACE) in Hepatocellular Carcinoma. Not yet recruiting NCT02715492 Phase 3 LMWH
48 A Randomized Placebo-controlled Double-blinded Trial of the Treatment of MRSA Throat Carriage With Either Standard Decolonization Therapy or Standard Decolonization Therapy Combined With Oral Clindamycin Not yet recruiting NCT04104178 Phase 3 Clindamycin;Placebo
49 A Phase 3 Multicenter, Randomized, Open-label, Clinical Trial of Telavancin Versus Standard Intravenous Therapy in the Treatment of Subjects With Staphylococcus Aureus Bacteremia Including Infective Endocarditis Terminated NCT02208063 Phase 3 Telavancin;Vancomycin;Daptomycin;Synthetic penicillin;Cefazolin
50 Evaluation de la rhAnnexine V-128 radiomarquée Dans le Diagnostic de l'Endocardite Infectieuse, du Thrombus Atrial et de Leurs Complications Emboliques associées Unknown status NCT02459613 Phase 1, Phase 2

Search NIH Clinical Center for Endocarditis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


GENTAMICIN SULFATE PWDR

Cochrane evidence based reviews: endocarditis

Genetic Tests for Endocarditis

Anatomical Context for Endocarditis

MalaCards organs/tissues related to Endocarditis:

40
Heart, Colon, Skin, Brain, Testes, Liver, Lung

Publications for Endocarditis

Articles related to Endocarditis:

(show top 50) (show all 30004)
# Title Authors PMID Year
1
Very late-onset endocarditis complicated by non-significant aortic regurgitation after device closure of perimembranous ventricular septal defect. 61 42
32384490 2020
2
Knowledge and Compliance of Dentists' and Dental Students' With Respect to Relevant Guidelines for Prescribing Antibiotic Prophylaxis for the Prevention of Infective Endocarditis: A Systematic Review. 42 61
32381401 2020
3
Woman With Rashes. 42
32471577 2020
4
Fibronectin-binding proteins and clumping factor A in Staphylococcus aureus experimental endocarditis: FnBPA is sufficient to activate human endothelial cells. 54 61
17393025 2007
5
Safety evaluation of Lactobacillus delbrueckii subsp. lactis UO 004, a probiotic bacterium. 54 61
15748979 2005
6
Bartonella koehlerae, a new cat-associated agent of culture-negative human endocarditis. 54 61
15297484 2004
7
Haemophilus parainfluenzae endocarditis in a patient with mitral valve prolapse. 61 54
8323254 1993
8
Activity of ampicillin plus sulbactam against beta-lactamase producing enterococci in experimental endocarditis. 61 54
8444668 1993
9
Killing curve activity of ciprofloxacin is comparable to synergistic effect of beta-lactam-tobramycin combinations against Haemophilus species endocarditis strains. 54 61
1389104 1992
10
Bromide-dependent toxicity of eosinophil peroxidase for endothelium and isolated working rat hearts: a model for eosinophilic endocarditis. 54 61
1985118 1991
11
Efficacy of amoxycillin/clavulanic acid in experimental Staphylococcus aureus endocarditis in the rat. 54 61
2050588 1991
12
A review on quinoline derivatives as anti-methicillin resistant Staphylococcus aureus (MRSA) agents. 61
32190843 2020
13
Asymptomatic bilateral obstructing ureteric calculi resulting in Lactobacillaemia and endocarditis requiring emergency aortic valve replacement. 61
32373471 2020
14
Kodamaea ohmeri infections in humans: A systematic review. 61
32323385 2020
15
Incidence and Surgical Outcomes of Patients With Native and Prosthetic Aortic Valve Endocarditis. 61
31794735 2020
16
Valve regurgitation in patients surviving endocarditis and the subsequent risk of heart failure. 61
31822570 2020
17
Non-infective endocarditis. 61
32376608 2020
18
Right-Sided Infective Endocarditis. 61
32509980 2020
19
Incidence and treatment costs of severe bacterial infections among people who inject heroin: A cohort study in South London, England. 61
32422537 2020
20
Imaging Cardiovascular Emergencies: Real World Clinical Cases. 61
32503756 2020
21
Atypical Manifestations of Cat-Scratch Disease, United States, 2005-2014. 61
32568056 2020
22
The biofilm-associated bacterial infections unrelated to indwelling devices. 61
32150327 2020
23
The Role of 18-F FDG PET/CT in Imaging of Endocarditis and Cardiac Device Infections. 61
32540029 2020
24
Widespread septic embolization in injection drug use mitro-aortic infective endocarditis as a remote cause of death. 61
32367331 2020
25
Evolving Spectrum of Prognostic Inflammatory Markers in Infective Endocarditis. 61
32147322 2020
26
Mechanical Versus Biologic Prostheses for Surgical Aortic Valve Replacement in Patients Aged 50 to 70. 61
31786289 2020
27
Prosthetic valve endocarditis following transcatheter aortic valve implantation. 61
32332380 2020
28
Right sinus of Valsalva aneurysm. 61
32145675 2020
29
Chemotherapy-associated nonbacterial thrombotic endocarditis: A radiological mimicker of cardiac amyloidosis requiring histopathologic examination for definitive diagnosis. 61
32142924 2020
30
Cavernous Thrombophlebitis Secondary to Cavernous Internal Carotid Mycotic Aneurysm. 61
32549947 2020
31
[Hemoglobin drop after thrombolytic therapy in a 57-year-old stroke patient with "erosive gastritis"]. 61
32533196 2020
32
Surgical Options for Aortic Root Replacement in Destructive Endocarditis. 61
32549097 2020
33
Prospective Validation of PREDICT and its Impact on the Transesophageal Echocardiography Use in Management of Staphylococcus aureus Bacteremia. 61
32569366 2020
34
Methodology for the development of a national Dental Practice-Based Research Network survey on dentist's beliefs and behaviors concerning antibiotic prophylaxis. 61
32540319 2020
35
Fungal endocarditis in transplant recipients: a systematic review. 61
32557938 2020
36
Central nervous system candidiasis beyond neonates: Lessons from a nationwide study. 61
32577733 2020
37
Heart Valve Endocarditis. 61
32520388 2020
38
Continuous Infusion Ampicillin for the Outpatient Management of Enterococcal Endocarditis: A Case Report and Literature Review. 61
30326771 2020
39
Heart transplantation for recurrent Cutibacterium (Propionibacterium) acnes prosthetic heart valve endocarditis. 61
32492244 2020
40
Association of Surgical Treatment With Survival in Patients With Prosthetic Valve Endocarditis. 61
31606518 2020
41
Rescue Aortic Root Replacement for Endocarditis After Transcatheter Aortic Valve Replacement. 61
31765621 2020
42
Incremental value of multimodal imaging in the evaluation of complicated prosthetic valve endocarditis. 61
32519980 2020
43
Response to the Letter by Ajay K Mishra and Co-workers Commenting on "Safety and Efficacy of Thrombolysis and Mechanical Thrombectomy in Infective Endocarditis". 61
32205027 2020
44
Matched Retrospective Study of Infective Endocarditis among Solid Organ Transplant Recipients Compared to Non-transplant: Seven- year Experience in a U.S. Referral Center. 61
32543012 2020
45
Impact of systematic whole-body 18F-fluorodeoxyglucose PET/CT on the management of patients suspected of infective endocarditis: the prospective multicenter TEPvENDO study. 61
32488236 2020
46
The diagnostic benefit of 16S rDNA PCR examination of infective endocarditis heart valves: a cohort study of 146 surgical cases confirmed by histopathology. 61
32488586 2020
47
A retrospective observational study on enterococcal bacteraemia and endocarditis at a regional hospital in New South Wales, Australia. 61
32561340 2020
48
Rapid-deployment aortic valve replacement in high-risk patients with severe endocarditis. 61
32558526 2020
49
Prediction of surgical risk in patients with endocarditis: Comparison of logistic EuroSCORE, EuroSCORE II and APORTEI score. 61
32553427 2020
50
TEG improves anticoagulation management during cardiopulmonary bypass complicated by antiphospholipid syndrome. 61
32302025 2020

Variations for Endocarditis

Expression for Endocarditis

Search GEO for disease gene expression data for Endocarditis.

Pathways for Endocarditis

Pathways related to Endocarditis according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 TNF TLR6 TLR2 LBP IL6 IL10
2
Show member pathways
12.79 TNF IL6 IL10 HSPD1 EPX CXCL8
3
Show member pathways
12.66 TNF TLR6 TLR2 IL6 CXCL8
4
Show member pathways
12.28 TNF TLR2 IL6 CXCL8
5
Show member pathways
12.28 TNF IL6 IL10 CXCL8
6 12.25 TNF TLR6 TLR2 IL6 CXCL8
7 12.21 TNF IL6 F2 CXCL8
8
Show member pathways
12.19 TNF TLR6 TLR2 IL6 CXCL8
9
Show member pathways
12.18 TNF IL6 F2 CRP CAT ALB
10 12.14 TNF TLR6 TLR2 IL6
11 12.1 TNF IL6 IL10 HSPD1 CXCL8
12
Show member pathways
12.02 TNF TLR6 TLR2 LBP IL6 CXCL8
13 11.97 TNF IL6 IL10 CXCL8
14 11.95 TNF IL6 IL10 GP1BA
15 11.91 TNF LBP IL6 IL10 CXCL8
16
Show member pathways
11.86 TNF TLR6 TLR2 IL6 IL10
17 11.82 TNF TLR2 IL6 CXCL8
18 11.81 TNF TLR2 IL6 IL10 CXCL8
19 11.71 TNF IL6 IL10 CXCL8
20 11.7 TNF IL6 IL10
21
Show member pathways
11.61 TNF IL6 CXCL8
22 11.61 TNF IL6 CXCL8
23 11.47 TNF IL6 GP1BA
24 11.47 TNF IL6 IL10 CXCL8
25 11.42 TNF TLR6 TLR2 LBP IL6 IL10
26 11.35 TNF IL6 IL10
27 11.32 TNF IL6 IL10
28 11.31 TNF TLR2 IL6 HSPD1 CXCL8
29 11.21 TNF IL6 IL10
30 11.05 TNF TLR2 IL6 IL10 CXCL8
31 10.84 TNF IL6 CXCL8 CRP

GO Terms for Endocarditis

Cellular components related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.85 SERPINC1 PIK3C2A LBP HSPD1 GP1BA F2
2 cell surface GO:0009986 9.73 TNF TLR2 LBP HSPD1 GP1BA APOH
3 extracellular region GO:0005576 9.73 TNF SERPINC1 LBP IL6 IL10 F2
4 extracellular space GO:0005615 9.47 TNF SERPINC1 LBP IL6 IL10 HSPD1

Biological processes related to Endocarditis according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.09 TNF TLR6 TLR2 IL6 CRP
2 immune response GO:0006955 10.07 TNF TLR6 TLR2 IL6 IL10 CXCL8
3 cytokine-mediated signaling pathway GO:0019221 10.01 TNF LBP IL6 IL10 CXCL8
4 inflammatory response GO:0006954 10.01 TNF TLR6 TLR2 IL6 CXCL8 CRP
5 cellular protein metabolic process GO:0044267 9.99 SERPINC1 IL6 F2 ALB
6 defense response to bacterium GO:0042742 9.97 TNF TLR6 LBP IL10 EPX
7 response to hypoxia GO:0001666 9.96 TLR2 HSPD1 CAT ADSL
8 response to lipopolysaccharide GO:0032496 9.96 TLR2 LBP IL10 HSPD1
9 cellular response to lipopolysaccharide GO:0071222 9.91 TNF LBP IL6 IL10 CXCL8
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 TNF TLR6 TLR2 IL6 CAT
11 cellular oxidant detoxification GO:0098869 9.87 EPX CAT ALB
12 response to insulin GO:0032868 9.87 TLR2 IL10 CAT
13 hemostasis GO:0007599 9.85 SERPINC1 GP1BA F2
14 response to activity GO:0014823 9.83 IL10 HSPD1 CAT
15 toll-like receptor signaling pathway GO:0002224 9.82 TLR6 TLR2 LBP
16 positive regulation of interleukin-6 secretion GO:2000778 9.82 TNF TLR2 HSPD1
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.81 TNF TLR2 LBP
18 response to glucocorticoid GO:0051384 9.8 TNF IL6 IL10 HSPD1
19 defense response to Gram-positive bacterium GO:0050830 9.8 TNF TLR2 LBP IL6 CRP
20 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.78 TLR6 TLR2 HSPD1
21 microglial cell activation GO:0001774 9.77 TNF TLR6 TLR2
22 positive regulation of interleukin-8 production GO:0032757 9.76 TNF TLR2 LBP
23 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.72 TNF TLR6 IL6
24 blood coagulation, intrinsic pathway GO:0007597 9.7 GP1BA F2 APOH
25 cellular response to lipoteichoic acid GO:0071223 9.69 TLR2 LBP
26 negative regulation of fibrinolysis GO:0051918 9.69 F2 APOH
27 opsonization GO:0008228 9.68 LBP CRP
28 endothelial cell apoptotic process GO:0072577 9.68 TNF IL10
29 cellular response to bacterial lipopeptide GO:0071221 9.68 TLR6 TLR2
30 cellular response to diacyl bacterial lipopeptide GO:0071726 9.67 TLR6 TLR2
31 negative regulation of cytokine production involved in immune response GO:0002719 9.67 TNF IL10
32 acute-phase response GO:0006953 9.67 LBP IL6 F2 CRP
33 negative regulation of cytokine secretion involved in immune response GO:0002740 9.65 TNF IL10
34 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.64 TLR6 TLR2
35 nitric oxide metabolic process GO:0046209 9.63 TLR6 TLR2
36 response to molecule of bacterial origin GO:0002237 9.63 TLR2 IL10 CXCL8
37 receptor biosynthetic process GO:0032800 9.62 TNF IL10
38 response to inactivity GO:0014854 9.62 IL10 CAT
39 positive regulation of JAK-STAT cascade GO:0046427 9.62 TNF IL6 IL10 F2
40 negative regulation of lipid storage GO:0010888 9.61 TNF IL6 CRP
41 detection of diacyl bacterial lipopeptide GO:0042496 9.57 TLR6 TLR2
42 response to bacterial lipoprotein GO:0032493 9.56 TLR6 TLR2
43 positive regulation of chemokine production GO:0032722 9.56 TNF TLR2 LBP IL6
44 positive regulation of macrophage activation GO:0043032 9.46 TLR6 LBP IL10 HSPD1
45 positive regulation of interleukin-6 production GO:0032755 9.35 TNF TLR2 LBP IL6 HSPD1
46 regulation of blood coagulation GO:0030193 8.92 SERPINC1 GP1BA F2 APOH

Molecular functions related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.65 TNF TLR6 TLR2 SERPINC1 LACTB CRP
2 cytokine activity GO:0005125 9.56 TNF IL6 IL10 CXCL8
3 lipopeptide binding GO:0071723 9.33 TLR6 TLR2 LBP
4 lipopolysaccharide binding GO:0001530 8.92 TLR2 LBP HSPD1 F2

Sources for Endocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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