Categories: Blood diseases, Cardiovascular diseases, Infectious diseases, Respiratory diseases

Aliases & Classifications for Endocarditis

MalaCards integrated aliases for Endocarditis:

Name: Endocarditis 12 73 54 42 44 15 62 17 70


External Ids:

Disease Ontology 12 DOID:10314
ICD9CM 34 421.9
MeSH 44 D004696
SNOMED-CT 67 56819008 91357005
ICD10 32 I33.9
UMLS 70 C0014118 C0375268

Summaries for Endocarditis

MedlinePlus : 42 Endocarditis, also called infective endocarditis (IE), is an inflammation of the inner lining of the heart. The most common type, bacterial endocarditis, occurs when germs enter your heart. These germs come through your bloodstream from another part of your body, often your mouth. Bacterial endocarditis can damage your heart valves. If untreated, it can be life-threatening. It is rare in healthy hearts. Risk factors include having An abnormal or damaged heart valve An artificial heart valve Congenital heart defects The signs and symptoms of IE can vary from person to person. They also can vary over time in the same person. Symptoms you might notice include fever, shortness of breath, fluid buildup in your arms or legs, tiny red spots on your skin, and weight loss. Your doctor will diagnose IE based on your risk factors, medical history, signs and symptoms, and lab and heart tests. Early treatment can help you avoid complications. Treatment usually involves high-dose antibiotics. If your heart valve is damaged, you may need surgery. If you're at risk for IE, brush and floss your teeth regularly, and have regular dental checkups. Germs from a gum infection can enter your bloodstream. If you are at high risk, your doctor might prescribe antibiotics before dental work and certain types of surgery. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Endocarditis is related to nonbacterial thrombotic endocarditis and infective endocarditis, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Endocarditis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs Rifampicin and Fosfomycin have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and liver, and related phenotypes are Reduced mammosphere formation and cardiovascular system

Disease Ontology : 12 A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves.

PubMed Health : 62 About endocarditis: Endocarditis (EN-do-kar-DI-tis) is an infection of the inner lining of the heart chambers and valves. This lining is called the endocardium (en-do-KAR-de-um). The condition also is called infective endocarditis (IE). The term "endocarditis" also is used to describe an inflammation of the endocardium due to other conditions. This article only discusses endocarditis related to infection. IE occurs if bacteria, fungi, or other germs invade your bloodstream and attach to abnormal areas of your heart. The infection can damage your heart and cause serious and sometimes fatal complications. IE can develop quickly or slowly; it depends on what type of germ is causing it and whether you have an underlying heart problem. When IE develops quickly, it's called acute infective endocarditis. When it develops slowly, it's called subacute infective endocarditis.

Wikipedia : 73 Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves... more...

Related Diseases for Endocarditis

Diseases in the Endocarditis family:

Subacute Bacterial Endocarditis

Diseases related to Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1518)
# Related Disease Score Top Affiliating Genes
1 nonbacterial thrombotic endocarditis 32.9 SERPINC1 PF4 IL6 F2 CRP APOH
2 infective endocarditis 32.6 TNNI3 TNF TLR2 PF4 LBP IL6
3 aortic valve insufficiency 31.9 TNNI3 F2 CRP ALB
4 mitral valve insufficiency 31.8 TNNI3 PIK3C2A F2 CRP ALB
5 brucellosis 31.7 TNF IL6 IL17A IL10 IFNG CXCL8
6 rheumatic heart disease 31.7 TNF TLR2 IL6 IL10
7 q fever 31.6 TNF TLR2 IL6 IL10 IFNG
8 congestive heart failure 31.6 TNNI3 TNF PIK3C2A IL6 CRP ALB
9 heart valve disease 31.5 TNNI3 F2 CRP APOH ALB
10 tricuspid valve insufficiency 31.5 TNNI3 F2 CRP ALB
11 cardiogenic shock 31.5 TNF IL6
12 intracranial embolism 31.4 SERPINC1 F2 CRP ALB
13 hemopericardium 31.4 TNNI3 F2 CRP
14 acute kidney failure 31.3 PIK3C2A F2 ALB
15 splenic abscess 31.3 LACTB F2 CRP ALB
16 mitral valve disease 31.3 TNNI3 IL10 F2 CRP
17 mitral valve stenosis 31.3 SERPINC1 PF4 F2 CRP
18 rheumatic fever 31.2 TNF TLR2 IL6 IL10 IFNG ALB
19 vasculitis 31.2 TNF IL6 IL17A HSPD1 CRP APOH
20 antiphospholipid syndrome 31.2 TNF SERPINC1 PF4 F2 CRP APOH
21 septic arthritis 31.1 TNF TLR2 IFNG CXCL8 CRP
22 atrial heart septal defect 31.1 TNNI3 SERPINC1 F2 CRP ALB
23 pericarditis 31.1 TNNI3 TNF IL6 IFNG CXCL8 CRP
24 splenic infarction 31.1 SERPINC1 F2 CRP APOH ALB
25 osteomyelitis 31.1 TNF TLR2 IL6 IL10 IFNG CXCL8
26 end stage renal disease 31.1 TNF IL6 IL10 CRP ALB
27 haemophilus influenzae 31.1 TNF TLR2 LACTB CXCL8
28 endomyocardial fibrosis 31.1 TNF IL10 EPX
29 pulmonary embolism 31.1 TNNI3 SERPINC1 GP1BA F2 CRP APOH
30 penicillin allergy 31.1 LACTB IL10 IFNG
31 aortitis 31.1 TNF IL6 IL17A CRP
32 endophthalmitis 31.0 TNF TLR2 IL6 CXCL8 CRP ALB
33 mediastinitis 31.0 LACTB F2 CRP ALB
34 pericardial effusion 31.0 TNNI3 PIK3C2A IL6 F2 CRP ALB
35 epidural abscess 31.0 F2 CRP ALB
36 tricuspid valve disease 30.9 TNNI3 F2 CRP ALB
37 disseminated intravascular coagulation 30.9 TNF SERPINC1 PIK3C2A IL6 IL10 F2
38 mycobacterium fortuitum 30.9 LACTB HSPD1 CXCL8
39 myocarditis 30.9 TNNI3 TNF PIK3C2A IL6 IL17A IL10
40 cardiac tamponade 30.9 TNNI3 PIK3C2A F2 CRP ALB
41 toxic shock syndrome 30.9 TNF TLR2 SERPINC1 LBP IL6 IL10
42 pleural empyema 30.9 IL6 F2 CRP ALB
43 limb ischemia 30.9 TNNI3 TNF IL6 F2
44 thrombophlebitis 30.8 SERPINC1 F2 CRP APOH ALB
45 cellulitis 30.8 TNF LACTB IL6 F2 CRP ALB
46 cryoglobulinemia 30.8 TNF IL6 IFNG APOH
47 thrombosis 30.8 SERPINC1 PF4 GP1BA F2 APOH
48 spondylitis 30.8 TNF IL6 IL17A IL10 IFNG CRP
49 acute myocardial infarction 30.7 TNNI3 SERPINC1 PIK3C2A PF4 IL6 CRP
50 branch retinal artery occlusion 30.7 SERPINC1 F2 CRP APOH

Graphical network of the top 20 diseases related to Endocarditis:

Diseases related to Endocarditis

Symptoms & Phenotypes for Endocarditis

UMLS symptoms related to Endocarditis:

angina pectoris; chest pain; edema

GenomeRNAi Phenotypes related to Endocarditis according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ALB CXCL8 GP1BA HSPD1 IL17A PIK3C2A

MGI Mouse Phenotypes related to Endocarditis:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.25 ALB CRP F2 HSPD1 IFNG IL10
2 homeostasis/metabolism MP:0005376 10.25 ALB APOH CRP EPX F2 GP1BA
3 hematopoietic system MP:0005397 10.18 EPX GP1BA HSPD1 IFNG IL10 IL17A
4 immune system MP:0005387 10.07 ALB CRP EPX F2 IFNG IL10
5 digestive/alimentary MP:0005381 10.01 ALB F2 IFNG IL10 IL17A IL6
6 liver/biliary system MP:0005370 9.76 ALB IFNG IL10 IL6 LBP SERPINC1
7 muscle MP:0005369 9.65 ALB F2 HSPD1 IFNG IL10 IL6
8 respiratory system MP:0005388 9.28 F2 HSPD1 IFNG IL10 IL17A IL6

Drugs & Therapeutics for Endocarditis

PubMed Health treatment related to Endocarditis: 62

Infective endocarditis (IE) is treated with antibiotics and sometimes with heart surgery .

Drugs for Endocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 146)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Rifampicin Approved Phase 4 13292-46-1 5381226 5458213
Fosfomycin Approved Phase 4 23155-02-4 446987
Imipenem Approved Phase 4 64221-86-9, 74431-23-5 104838
tannic acid Approved Phase 4 1401-55-4
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
Oritavancin Approved, Investigational Phase 4 171099-57-3 16129632
Daptomycin Approved, Investigational Phase 4 103060-53-3 16129629
Vancomycin Approved Phase 4 1404-90-6 14969 441141
Ceftaroline fosamil Approved, Investigational Phase 4 229016-73-3
Linezolid Approved, Investigational Phase 4 165800-03-3 441401
11 Amoxicillin-Potassium Clavulanate Combination Phase 4
12 Clavulanic Acids Phase 4
13 Anesthetics Phase 4
14 Analgesics, Opioid Phase 4
15 Antitubercular Agents Phase 4
16 Anti-Bacterial Agents Phase 4
17 Anti-Infective Agents Phase 4
18 Antibiotics, Antitubercular Phase 4
19 methicillin Phase 4
20 Gentamicins Phase 4
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
Ofloxacin Approved Phase 3 82419-36-1 4583
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
Ceftriaxone Approved Phase 3 73384-59-5 5479530 5361919
Netilmicin Approved, Investigational Phase 3 56391-56-1 6857423 441306
Procaine Approved, Investigational, Vet_approved Phase 3 59-46-1 4914
Penicillin G Approved, Vet_approved Phase 3 61-33-6 5904
Ceftobiprole Approved, Investigational Phase 3 209467-52-7 6918430
Aztreonam Approved Phase 3 78110-38-0 5362041 5742832
Cloxacillin Approved, Investigational, Vet_approved Phase 3 61-72-3 6098
Oxacillin Approved, Investigational Phase 3 66-79-5 6196
Cefazolin Approved Phase 3 25953-19-9 33255 656510
Telavancin Approved Phase 3 372151-71-8
Nafcillin Approved, Investigational Phase 3 147-52-4, 985-16-0 8982
Ceftobiprole medocaril Experimental, Investigational Phase 3 376653-43-9
36 Cytochrome P-450 Enzyme Inhibitors Phase 3
37 Fluoroquinolones Phase 3
38 Penicillin G Procaine Phase 3
39 Penicillin G Benzathine Phase 3
40 penicillins Phase 3
Dalbavancin Approved, Investigational Phase 2 171500-79-1, 91097-81-3 122186
42 Annexin A5 Phase 1, Phase 2
Dexmedetomidine Approved, Vet_approved 113775-47-6 5311068 68602
Trovafloxacin Approved, Investigational, Withdrawn 147059-72-1 62959
Povidone Approved 9003-39-8 131751496
Dopamine Approved 62-31-7, 51-61-6 681
Cidofovir Approved 113852-37-2 60613
Methylprednisolone Approved, Vet_approved 83-43-2 6741
Aminocaproic acid Approved, Investigational 60-32-2 564
Prednisolone Approved, Vet_approved 50-24-8 5755

Interventional clinical trials:

(show top 50) (show all 108)
# Name Status NCT ID Phase Drugs
1 An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Unknown status NCT02783404 Phase 4 Amoxicillin;Amoxicillin-Potassium Clavulanate
2 Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study: a Multicenter, Prospective, Randomized Trial Comparing the State-of-the-Art Therapeutic Strategy Versus Early Surgery Strategy in Infective Endocarditis Unknown status NCT00624091 Phase 4
3 The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials Unknown status NCT03112356 Phase 4 99mTc-Leukoscan® scintigraphy
4 Pharmacokinetics/ Pharmacodynamics (PK/PD) Study of Vancomycin in the Treatment of Methicillin-resistant Staphylococcus Aureus(MRSA) Blood Stream Infection (Septicemia) and Endocarditis in Chinese Patients Unknown status NCT02443064 Phase 4 Vancomycin
5 A Randomized Comparison of Early Surgery Versus Conventional Treatment Strategy in Patients With High Embolic Risk of Infective Endocarditis Completed NCT00750373 Phase 4
6 Evaluation of the Efficacy and Safety of Fosfomycin Plus Imipenem for the Treatment of Methicillin-resistant Staphylococcus Aureus (MRSA) Infective Endocarditis. Completed NCT00871104 Phase 4 Fosfomycin and imipenem;Vancomycin
7 Partial Oral Treatment of Endocarditis Completed NCT01375257 Phase 4 Oral treatment with antibiotics for endocarditis;Guideline treatment with parenteral antibiotics
8 The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Completed NCT01920126 Phase 4 sodium bicarbonate;Saline
9 Health Economic Evaluation of Rapid Detection of Bacteraemia and Fungemia by Real Time PCR for Cases of Febrile Neutropenia, Suspicion of Endocarditis and Severe Sepsis in Intensive Care Units Completed NCT00709358 Phase 4
10 Short-course Antibiotic Regimen Compared to Conventional Antibiotic Treatment for Gram-positive Cocci Infective Endocarditis: Randomized Clinical Trial Recruiting NCT04222257 Phase 4 Antibiotics;Antibiotics
11 A Pilot Proof of Concept Single-Center Study of the Use of Oritavancin in Systemic Staphylococcus Aureus Infections in Patients With Opioid Use Disorder Recruiting NCT03761953 Phase 4 Oritavancin Injection
12 A Phase 4 Multicenter, Randomized, Double Blind Study to Describe the Efficacy and Safety of Cubicin® (Daptomycin for Injection) With and Without Initial Gentamicin Combination Therapy in the Treatment of S. Aureus Infective Endocarditis Terminated NCT00638157 Phase 4 daptomycin;daptomycin and gentamicin
13 Open Label Study to Assess the Efficacy and Safety of Daptomycin in Combination With Anti-Cell Wall Active Therapy in the Treatment of Enterococcal Endocarditis Terminated NCT00401960 Phase 4 Daptomycin
14 Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients Terminated NCT01734694 Phase 4 Vancomycin;Ceftaroline;Daptomycin;Linezolid
15 A Phase 3, Multicenter, Randomized, Open-Label, Comparative Study to Assess the Safety and Efficacy of Daptomycin Compared to Conventional Therapy In the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to Staph Aureus Completed NCT00093067 Phase 3 daptomycin
16 A Phase III Randomized, Open-labeled Clinical Trial of MK-3009 (Daptomycin) in Patients With Skin and Soft Tissue Infections, Septicemia and Right-sided Infective Endocarditis Caused by MRSA Completed NCT00770341 Phase 3 Daptomycin 4 mg/kg;Comparator: vancomycin;Daptomycin 6 mg/kg
17 Population Pharmacokinetic (PK) Study of Multiple Doses of Cubicin® (Daptomycin) 10 mg/kg in Critical Care Patients Having Bacteremia, Endocarditis or Skin Soft Tissue Infections Due to Gram Positive Bacteria With Various Degrees of Renal Failure Completed NCT02142075 Phase 3 Daptomycin
18 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus (Relais Oral Dans le Traitement Des Endocardites à Streptocoques Multi-sensibles) Recruiting NCT02701595 Phase 3 Amoxicillin
19 Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus (Relais Oral Dans le Traitement Des Endocardites à Staphylocoques Multi-sensibles) Recruiting NCT02701608 Phase 3 Levofloxacin;Rifampicin
20 A Randomized, Double-blind, Multi-center Study to Establish the Efficacy and Safety of Ceftobiprole Medocaril Compared to Daptomycin in the Treatment of Staphylococcus Aureus Bacteremia, Including Infective Endocarditis Recruiting NCT03138733 Phase 3 Ceftobiprole medocaril;Daptomycin
21 A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of a Single Dose of Exebacase in Patients Receiving Standard-of-Care Antibiotics for the Treatment of Staphylococcus Aureus Bloodstream Infections (Bacteremia), Including Right-Sided Infective Endocarditis Recruiting NCT04160468 Phase 3 Exebacase;Placebo
22 A Phase 3 Multicenter, Randomized, Open-label, Clinical Trial of Telavancin Versus Standard Intravenous Therapy in the Treatment of Subjects With Staphylococcus Aureus Bacteremia Including Infective Endocarditis Terminated NCT02208063 Phase 3 Telavancin;Vancomycin;Daptomycin;Synthetic penicillin;Cefazolin
23 Phase II Clinical Trial to Evaluate an Antibiotic Regimen Pharmacokinetic Applicable to Outpatient Parenteral Antimicrobial Therapy in Enterococcus Faecalis Infective Endocarditis Unknown status NCT03681431 Phase 2 Ceftriaxone 4g/ 24h;Ceftriaxone 2g/ 12h
24 Evaluation de la rhAnnexine V-128 radiomarquée Dans le Diagnostic de l'Endocardite Infectieuse, du Thrombus Atrial et de Leurs Complications Emboliques associées Unknown status NCT02459613 Phase 1, Phase 2
25 A Multicenter, Double-Blind, Randomized, Comparative Study of the Safety, Tolerability, Efficacy, and Pharmacokinetics of CF-301 vs. Placebo in Addition to Standard-of-Care Antibacterial Therapy for the Treatment of Adult Patients With Staphylococcus Aureus Bloodstream Infections (Bacteremia) Including Endocarditis Completed NCT03163446 Phase 2 Placebo
26 Hyperbaric Oxygen Treatment in Humans With Gram Positive Cocci Endocarditis" Recruiting NCT04691440 Phase 2 Hyperbaric oxygen
27 A Multi-centre Open Label Randomized Controlled Phase IIB Trial Comparing Vancomycin Versus Daptomycin for the Treatment of MRSA Bacteremia Due to Isolates With High Vancomycin Minimum Inhibitory Concentrations Terminated NCT01975662 Phase 2 Daptomycin;Vancomycin
28 Phase 2, Open-Label, Randomized, Multicenter Study to Compare the Efficacy and Safety of Dalbavancin to Standard of Care Antibiotic Therapy for the Completion of Treatment of Patients With Complicated Bacteremia or Documented Infective Endocarditis Terminated NCT03148756 Phase 2 Dalbavancin;Standard of Care
29 A Phase 2 Multicenter, Randomized, Double-blinded, Study to Describe the Safety, Efficacy, and Pharmacokinetics of Daptomycin 10 mg/kg/Day and Vancomycin for the Treatment of Methicillin-resistant Staphylococcus Aureus Bacteremia Terminated NCT00695903 Phase 2 daptomycin;vancomycin
30 Multi-centre, Randomised, Open Label, Phase IIb Study to Compare the Efficacy, Safety and Pharmacokinetics (PK) of an Optimised Dosing to a Standard Dosing Regimen of Vancomycin in Neonates and Infants Aged ≤ 90 Days With Late Onset Bacterial Sepsis Known or Suspected to be Caused by Gram-positive Microorganisms Terminated NCT02790996 Phase 2 Vancomycin
31 Impact of Setting up a Multidisciplinary Consensus Meeting in the Prognosis and Management of Infectious Endocarditis at Strasbourg University Hospital. Unknown status NCT03429153
32 Etiology of Endocarditis in Negative Blood Cultures Unknown status NCT02816307
33 Impact of Clinical Care Pathway on Prognosis and Therapeutic Medical Care of Infective Endocarditis Unknown status NCT02856607
34 Molecular Imaging in Infective Endocarditis Using Hybrid Positron Emission Tomography/Magnetic Resonance Imaging (PET/MR) and Computed Tomography (PET/CT) Unknown status NCT03626571
35 Long-term Clinico-radiological Evolution of Patients With Symptomatic and Asymptomatic Brain Lesions During Infectious Endocarditis Unknown status NCT02252900
36 The Use of Cardiac Computarized Tomography in Infective Endocarditis Unknown status NCT00550823
37 Treatment of Infective Endocarditis by Vancomycin and Gentamycin in Assiut University Children Hospital Unknown status NCT03688659 Vancomycin and gentamycin
38 Study of Autoantibodies in Infective Endocarditis Unknown status NCT00562653
39 Detection of the Most Common Micro Organism of Infective Endocarditis in Assiut University Hospital Unknown status NCT03487653
40 Beta-lactam Pharmacokinetic Profiles in Patients With Infective Endocarditis Unknown status NCT02033421
41 Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study Unknown status NCT02128139
42 Research Interest Antiphospholipid in Predicting Embolic Risk During Infective Endocarditis Unknown status NCT02887079
43 Effect of Dexmedetomidine on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery Unknown status NCT02698930 dexmedetomidine;Normal saline
44 Stroke-free Survival Comparison Between Early Surgery and Conventional Therapy in Left Infective Endocarditis - A Multicenter Partially Randomized Preference Trial (EARLY Study) Unknown status NCT03411499
45 Clinical Metagenomics of Infective Endocarditis Unknown status NCT03199287
46 Positron Emission Tomography Combined With Computed Tomography (PET CT) in Suspected Cardiovascular Implantable Electronic Device Infection, a Pilot Study - PET Guidance I Unknown status NCT02196753
47 Development of the Purification of Human Cardiac Mitochondria, Characterization of These Organelles and Validation of the Model in Acute Endocarditis and Obesity Unknown status NCT03690076
48 Diagnostic Value of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Prosthetic Valve Endocarditis Unknown status NCT01916005
49 Assessment of Diagnostic Accuracy of 18FDG-PET-CT in Patients With Suspicion of Pacing or Defibrillation Lead Infection: a Prospective Multi-center Study Unknown status NCT02251262
50 Retrospective Evaluation of Safety and Efficacy of Daptomycin Used in Patients With Serious Gram-positive Infections Unknown status NCT01301638

Search NIH Clinical Center for Endocarditis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Cochrane evidence based reviews: endocarditis

Genetic Tests for Endocarditis

Anatomical Context for Endocarditis

MalaCards organs/tissues related to Endocarditis:

Heart, Brain, Liver, Kidney, Skin, Endothelial, Colon

Publications for Endocarditis

Articles related to Endocarditis:

(show top 50) (show all 30003)
# Title Authors PMID Year
Patients with infective endocarditis and history of injection drug use in a Swedish referral hospital during 10 years. 42 61
33653292 2021
Dental Medicine and Infective Endocarditis: Current guidelines for antibiotic prophylaxis and recommendations for daily clinical practice. 61 42
33666387 2021
Synthesis of silver nanoparticles using gum Arabic: Evaluation of its inhibitory action on Streptococcus mutans causing dental caries and endocarditis. 61 42
33618277 2021
Fibronectin-binding proteins and clumping factor A in Staphylococcus aureus experimental endocarditis: FnBPA is sufficient to activate human endothelial cells. 61 54
17393025 2007
Bartonella koehlerae, a new cat-associated agent of culture-negative human endocarditis. 61 54
15297484 2004
Haemophilus parainfluenzae endocarditis in a patient with mitral valve prolapse. 61 54
8323254 1993
Activity of ampicillin plus sulbactam against beta-lactamase producing enterococci in experimental endocarditis. 54 61
8444668 1993
Killing curve activity of ciprofloxacin is comparable to synergistic effect of beta-lactam-tobramycin combinations against Haemophilus species endocarditis strains. 54 61
1389104 1992
Thiocyanate is the major substrate for eosinophil peroxidase in physiologic fluids. Implications for cytotoxicity. 61 54
2002037 1991
Efficacy of amoxycillin/clavulanic acid in experimental Staphylococcus aureus endocarditis in the rat. 61 54
2050588 1991
Bromide-dependent toxicity of eosinophil peroxidase for endothelium and isolated working rat hearts: a model for eosinophilic endocarditis. 61 54
1985118 1991
Methicillin-resistant Staphylococcus pseudintermedius synthesizes deoxyadenosine to cause persistent infection. 61
33779509 2021
Simultaneous bilateral choroidal neovascularization associated with Staphylococcus aureus infective endocarditis: A case report. 61
33681530 2021
Sterile subconjunctival abscess in an HLA-B51-positive patient with ulcerative colitis. 61
33659764 2021
Loeffler's Endocarditis and Hypereosinophilic Syndrome. 61
32520731 2021
Severe Tricuspid Regurgitation in an Elderly Man With a Pacemaker Generator Eroding Through the Skin: Endocarditis, Perforation, Lead-Induced Impingement, or Another Mechanism? 61
33158708 2021
First case report of prosthetic valve endocarditis caused by Mycobacterium wolinskyi. 61
33402304 2021
Infective endocarditis in patients with aortic grafts. 61
33592240 2021
Long-term follow-up of patients with infective endocarditis in a tertiary referral center. 61
33545260 2021
Clinical characteristics and outcomes in patients with echocardiographic left ventricular spontaneous echo contrast. 61
33577908 2021
Multimodality Imaging-Guided Evaluation and Management of Prosthetic Aortic Valve Endocarditis Complicated by a Giant Peri-Aortic Abscess. 61
33794651 2021
Dialysis and Endocarditis: Proving What We Know, Learning What We Didn't. 61
33795038 2021
Commentary: Endocarditis of the forgotten valve: Forget about valvectomy? 61
32007250 2021
Microbubbles Mimicking Prosthetic Mitral Valve Thrombosis. 61
33794483 2021
Morbidity and Mortality of Spinal Epidural Abscess in End-Stage Renal Disease Patients: A Case-Control Study. 61
33637307 2021
Multimodality Evaluation of a Septal Cystic Cavity and Ventricular Septal Defect in the Setting of Neurocysticercosis and Endocarditis. 61
33794648 2021
Medications for Opioid use Disorder Associated With Less Against Medical Advice Discharge Among Persons Who Inject Drugs Hospitalized With an Invasive Infection. 61
32804690 2021
Role or oritavancin and dalbavancin in acute bacterial skin and skin structure infections and other potential indications. 61
33405480 2021
Dental caries prevalence in children with congenital heart disease - a systematic review. 61
33415995 2021
Minimally-invasive mitral valve repair of symmetric and asymmetric Barlow´s disease. 61
33792775 2021
Sutureless aortic valves in elderly patients with aortic stenosis and intermediate-risk profile. 61
33633045 2021
Endomyocardiofibrosis: A Systematic Review. 61
33418479 2021
Mitral Valve Surgery After Failed MitraClip: A Single-Center Experience. 61
33794477 2021
Perceval Sutureless Aortic Valve Implantation: Midterm Outcomes. 61
32866479 2021
Distant metastatic foci of infection in adult patients with diabetic foot - not as rare as we think?: case series and review of the literature. 61
33423592 2021
Neuropathological spectrum in systemic lupus erythematosus: A single institute autopsy experience. 61
33601129 2021
Risk Factors for Postoperative Pacemaker Implantation After Rapid Deployment Aortic Valve Replacement: Results from the RADAR Registry. 61
33665760 2021
Pulmonary valve replacement via left anterior minithoracotomy: Lessons learned and early experience. 61
33533086 2021
Commercial Air Travel for Passengers With Cardiovascular Disease: Recommendations for Less Common Conditions, Considerations for Venous Thromboembolism, and General Guidance. 61
33412348 2021
Exploring the socioeconomic consequences of infective endocarditis. 61
32331699 2021
Usefulness of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Diagnosis of Infective Endocarditis in Patients With Adult Congenital Heart Disease. 61
33790144 2021
Optimum surgical treatment for tricuspid valve infective endocarditis: An analysis of the Society of Thoracic Surgeons national database. 61
31864695 2021
Huge Mycotic Aneurysm at the Celiac Trunk in a Patient With Severe Aortic Regurgitation Due to Infective Endocarditis. 61
33790145 2021
Serratia Marcescens Infective Endocarditis Complicated by Aortic Root Abscess and Aorta to Right Atrial Fistula. 61
33262023 2021
Infective endocarditis in patients with heart transplantation. 61
33309761 2021
Infective Endocarditis in Patients on Chronic Hemodialysis. 61
33795037 2021
Analysis of the frequency of bacteraemia of dental origin implicated in infective endocarditis in patients requiring valve surgery. 61
33293181 2021
Ceftaroline fosamil: clinical experience after 23-month prescription in a tertiary hospital. 61
33586407 2021
Late Surgical Treatment for Transcatheter Aortic Valve Prosthesis Dysfunction. 61
32979373 2021
A prospective comparison of four methods for preventing pacemaker pocket infections. 61
33001439 2021

Variations for Endocarditis

Expression for Endocarditis

Search GEO for disease gene expression data for Endocarditis.

Pathways for Endocarditis

Pathways related to Endocarditis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
Show member pathways
Show member pathways
Show member pathways
12.63 TNF TLR2 IL6 IL17A IL10 IFNG
Show member pathways
12.62 TNF TLR2 IL6 IL17A IL10 IFNG
Show member pathways
12.6 TNF IL6 IL17A IL10 IFNG F2
8 12.59 TNF TLR2 IL17A IL10 IFNG
Show member pathways
12.37 TNF PF4 IL6 IL10 CXCL8
Show member pathways
Show member pathways
Show member pathways
Show member pathways
Show member pathways
12.28 TNF TLR2 IL6 CXCL8
Show member pathways
12.28 TNF TLR2 IL10 IFNG
16 12.21 TNF TLR2 IL6 IFNG
Show member pathways
18 12.18 TNF IL6 IL10 HSPD1 CXCL8
Show member pathways
20 12.12 TNF IL6 IL10 CXCL8
21 12.05 TNF IL6 IFNG CXCL8
22 12.02 TNF IL6 IL10 IFNG GP1BA
23 11.96 TNF TLR2 LBP IL6 IL10 IFNG
Show member pathways
11.92 LBP IL6 IL17A CXCL8
Show member pathways
11.91 TLR2 IL6 IL17A IFNG
26 11.9 TNF LBP IL6 IL17A IL10 CXCL8
27 11.84 TNF IL17A IL10 IFNG
28 11.81 TNF IL6 IL10 CXCL8
29 11.81 TNF TLR2 IL6 IL10 IFNG CXCL8
30 11.79 TNF IL6 IL10 IFNG
Show member pathways
32 11.74 TNF TLR2 IL6 IL10
34 11.68 TNF IL6 CXCL8
Show member pathways
36 11.62 IL6 IFNG CXCL8
37 11.58 TNF IL6 IFNG
38 11.56 TNF IL6 IL10 CXCL8
39 11.56 TNF TLR2 IL6 HSPD1 CXCL8
40 11.55 TNF TLR2 IFNG
41 11.55 TNF IL6 GP1BA
42 11.51 TNF IL6 IFNG
43 11.42 TNF IL6 IL10 IFNG
Show member pathways
11.41 TNF IL10 IFNG
45 11.39 TNF IL6 IL10
46 11.33 TNF IL6 IL17A IFNG
Show member pathways
11.31 TNF TLR2 IL6 IL17A IL10 IFNG
48 11.26 TNF IL6 IL10 IFNG
49 11.23 TLR2 IFNG F2
50 11.05 TNF PF4 IL6 IL17A IL10 CXCL8

GO Terms for Endocarditis

Cellular components related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 SERPINC1 PIK3C2A LBP HSPD1 GP1BA F2
2 extracellular region GO:0005576 9.8 TNF SERPINC1 PF4 LBP IL6 IL17A
3 cell surface GO:0009986 9.63 TNF TLR2 LBP HSPD1 GP1BA APOH
4 extracellular space GO:0005615 9.53 TNF SERPINC1 PF4 LBP IL6 IL17A

Biological processes related to Endocarditis according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.08 TNF TLR2 PF4 IL6 IFNG CXCL8
2 immune response GO:0006955 10.01 TNF TLR2 PF4 IL6 IL17A IL10
3 cellular protein metabolic process GO:0044267 10 SERPINC1 IL6 F2 ALB
4 inflammatory response GO:0006954 10 TNF TLR2 PF4 IL6 IL17A CXCL8
5 response to lipopolysaccharide GO:0032496 9.96 TLR2 LBP IL10 HSPD1
6 defense response GO:0006952 9.95 TNF PF4 EPX CXCL8
7 platelet activation GO:0030168 9.93 PF4 IL6 GP1BA F2
8 positive regulation of inflammatory response GO:0050729 9.91 TNF TLR2 IFNG HSPD1
9 cellular response to lipopolysaccharide GO:0071222 9.91 TNF PF4 LBP IL6 IL10 CXCL8
10 cytokine-mediated signaling pathway GO:0019221 9.91 TNF PF4 LBP IL6 IL17A IL10
11 response to glucocorticoid GO:0051384 9.88 TNF IL6 IL10 HSPD1
12 regulation of insulin secretion GO:0050796 9.87 TNF IL6 IFNG
13 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.87 PF4 F2 CXCL8
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.87 TNF IL6 IFNG
15 positive regulation of interleukin-8 production GO:0032757 9.87 TNF TLR2 LBP IL6
16 positive regulation of interleukin-1 beta production GO:0032731 9.86 TNF IL6 IL17A IFNG
17 humoral immune response GO:0006959 9.85 TNF IL6 IFNG
18 positive regulation of cytokine production GO:0001819 9.85 TNF IL10 IFNG
19 hemostasis GO:0007599 9.84 SERPINC1 GP1BA F2
20 response to activity GO:0014823 9.83 IL6 IL10 HSPD1
21 positive regulation of interleukin-10 production GO:0032733 9.82 TLR2 IL6 HSPD1
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.81 TNF TLR2 LBP
23 microglial cell activation GO:0001774 9.81 TNF TLR2 IFNG
24 positive regulation of interleukin-12 production GO:0032735 9.81 TLR2 IL17A IFNG HSPD1
25 acute-phase response GO:0006953 9.8 LBP IL6 F2 CRP
26 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.79 TNF IL6 IL17A
27 positive regulation of JAK-STAT cascade GO:0046427 9.78 TNF IL6 IL10 F2
28 positive regulation of osteoclast differentiation GO:0045672 9.77 TNF IL17A IFNG
29 positive regulation of macrophage activation GO:0043032 9.77 LBP IL10 HSPD1
30 blood coagulation, intrinsic pathway GO:0007597 9.76 GP1BA F2 APOH
31 defense response to Gram-positive bacterium GO:0050830 9.73 TNF TLR2 LBP IL6 IL17A CRP
32 response to molecule of bacterial origin GO:0002237 9.72 TLR2 IL10 CXCL8
33 cellular response to lipoteichoic acid GO:0071223 9.7 TLR2 LBP
34 negative regulation of fibrinolysis GO:0051918 9.7 F2 APOH
35 negative regulation of lipid storage GO:0010888 9.7 TNF IL6 CRP
36 endothelial cell apoptotic process GO:0072577 9.69 TNF IL10
37 vascular endothelial growth factor production GO:0010573 9.68 TNF IL6
38 opsonization GO:0008228 9.68 LBP CRP
39 negative regulation of MHC class II biosynthetic process GO:0045347 9.67 PF4 IL10
40 negative regulation of cytokine production involved in immune response GO:0002719 9.67 TNF IL10
41 positive regulation of interleukin-23 production GO:0032747 9.65 IL17A IFNG
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.64 TNF IFNG
43 positive regulation of vitamin D biosynthetic process GO:0060557 9.62 TNF IFNG
44 positive regulation of nitrogen compound metabolic process GO:0051173 9.62 TNF IFNG
45 regulation of blood coagulation GO:0030193 9.62 SERPINC1 GP1BA F2 APOH
46 positive regulation of chemokine production GO:0032722 9.55 TNF TLR2 LBP IL6 IFNG
47 positive regulation of tumor necrosis factor production GO:0032760 9.43 TLR2 PF4 LBP IL6 IL17A IFNG
48 positive regulation of interleukin-6 production GO:0032755 9.17 TNF TLR2 LBP IL6 IL17A IFNG

Molecular functions related to Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.46 SERPINC1 PF4 F2 APOH
2 lipopeptide binding GO:0071723 9.26 TLR2 LBP
3 lipopolysaccharide binding GO:0001530 9.26 TLR2 LBP HSPD1 F2
4 cytokine activity GO:0005125 9.17 TNF PF4 IL6 IL17A IL10 IFNG

Sources for Endocarditis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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