MCID: END074
MIFTS: 26

Endocardium Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Endocardium Disease

MalaCards integrated aliases for Endocardium Disease:

Name: Endocardium Disease 12 15
Abnormality of the Endocardium 29

Classifications:



External Ids:

Disease Ontology 12 DOID:0050825

Summaries for Endocardium Disease

Disease Ontology : 12 A heart disease that is located in the innermost layer of tissue that lines the chambers of the heart.

MalaCards based summary : Endocardium Disease, also known as abnormality of the endocardium, is related to endocarditis and endocardial fibroelastosis. An important gene associated with Endocardium Disease is TAZ (Tafazzin), and among its related pathways/superpathways are Complement and coagulation cascades and Microglia Activation During Neuroinflammation: Overview. Affiliated tissues include the innermost layer of tissue, heart and bone, and related phenotypes are cardiovascular system and cellular

Related Diseases for Endocardium Disease

Diseases related to Endocardium Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 endocarditis 31.8 CRP F2 HSPD1
2 endocardial fibroelastosis 11.1
3 gastrointestinal tuberculosis 10.3 CRP SMUG1
4 aortitis 10.3 CRP SMUG1
5 mediastinitis 10.3 CRP NKX2-6
6 malignant otitis externa 10.3 CRP F2
7 bone epithelioid hemangioma 10.3 F3 SMUG1
8 partial motor epilepsy 10.3 F3 SMUG1
9 bursitis 10.2 CRP SH3BP5
10 anomalous left coronary artery from the pulmonary artery 10.2 SMUG1 TAZ
11 chronic thromboembolic pulmonary hypertension 10.2 CRP F2
12 abdominal tuberculosis 10.2 CRP F2
13 ischemic neuropathy 10.2 CRP F2
14 prothrombin deficiency 10.2 F2 F3
15 fournier gangrene 10.2 F2 F3
16 cardiac rupture 10.2 CRP PRF1
17 cerebral sinovenous thrombosis 10.2 F2 F3
18 salpingitis 10.2 CRP HSPD1
19 cartilage disease 10.2 CRP SMUG1
20 pulmonary artery leiomyosarcoma 10.2 PLG SMUG1
21 qualitative platelet defect 10.2 F2 F3
22 conjugate gaze palsy 10.2 F3 PLG
23 hepatic tuberculosis 10.2 F2 SMUG1
24 sagittal sinus thrombosis 10.2 F2 F3
25 eccrine adenocarcinoma 10.2 F2 SMUG1
26 tolosa-hunt syndrome 10.2 PRTN3 SMUG1
27 infective endocarditis 10.2 CRP F2 SH3BP5
28 alcohol-related birth defect 10.2 F2 F3
29 hantavirus pulmonary syndrome 10.2 F2 F3
30 alpha-2-plasmin inhibitor deficiency 10.2 F2 PLG
31 von willebrand disease, type 1 10.2 F2 F3
32 granulomatous myositis 10.2 PRTN3 SMUG1
33 intracranial embolism 10.2 F2 PLG
34 peripheral vertigo 10.2 CRP F2 F3
35 thrombocytosis 10.1 CRP F2 F3
36 pulmonary embolism 10.1 CRP F2 F3
37 peripheral vascular disease 10.1 CRP F2 F3
38 purpura 10.1 CRP F2 F3
39 marantic endocarditis 10.1 F2 F3
40 gastrointestinal system disease 10.1 CRP F2 SMUG1
41 intermediate coronary syndrome 10.1 CRP F3 PLG
42 multicentric castleman disease 10.1 CRP F3
43 blood group, globoside system 10.1 PLG PRF1
44 pericardial tuberculosis 10.1 PRTN3 SMUG1
45 arteries, anomalies of 10.1 CRP F3 PLG
46 vascular hemostatic disease 10.1 F2 F3
47 rapidly progressive glomerulonephritis 10.1 CRP PRTN3
48 arteriosclerosis 10.1 CRP F3 HSPD1
49 muscular disease 10.1 CRP MTM1 SMUG1 TAZ
50 squamous cell papilloma 10.1 F2 F3 HSPD1

Graphical network of the top 20 diseases related to Endocardium Disease:



Diseases related to Endocardium Disease

Symptoms & Phenotypes for Endocardium Disease

MGI Mouse Phenotypes related to Endocardium Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.9 CRP DLL1 F2 F3 MRTFA MTM1
2 cellular MP:0005384 9.7 DLL1 F3 HSPD1 MRTFA MTM1 NKX2-6
3 mortality/aging MP:0010768 9.36 DLL1 F2 F3 HSPD1 MRTFA MTM1

Drugs & Therapeutics for Endocardium Disease

Search Clinical Trials , NIH Clinical Center for Endocardium Disease

Genetic Tests for Endocardium Disease

Genetic tests related to Endocardium Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Endocardium 29

Anatomical Context for Endocardium Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Endocardium Disease:

19
The Innermost Layer Of Tissue

MalaCards organs/tissues related to Endocardium Disease:

41
Heart, Bone

Publications for Endocardium Disease

Variations for Endocardium Disease

Expression for Endocardium Disease

Search GEO for disease gene expression data for Endocardium Disease.

Pathways for Endocardium Disease

GO Terms for Endocardium Disease

Cellular components related to Endocardium Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 CRP F2 F3 HSPD1 PLG PRTN3
2 extracellular region GO:0005576 9.76 CRP DLL1 F2 F3 PLG PLXDC1
3 collagen-containing extracellular matrix GO:0062023 9.26 F3 PLG PRTN3 SERPINH1
4 membrane raft GO:0045121 8.92 DLL1 HSPD1 PRTN3 SERPINH1

Biological processes related to Endocardium Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.77 DLL1 F2 MATK NKX2-6 PRTN3
2 blood coagulation GO:0007596 9.56 F2 F3 PLG PRTN3
3 fibrinolysis GO:0042730 9.43 F2 PLG
4 protein maturation GO:0051604 9.4 HSPD1 SERPINH1
5 negative regulation of fibrinolysis GO:0051918 9.32 F2 PLG
6 interaction with symbiont GO:0051702 9.16 HSPD1 PLG
7 hemostasis GO:0007599 9.13 F2 F3 PLG
8 positive regulation of skeletal muscle tissue growth GO:0048633 8.62 DLL1 MTM1

Molecular functions related to Endocardium Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apolipoprotein binding GO:0034185 8.96 HSPD1 PLG
2 serine-type endopeptidase activity GO:0004252 8.92 F2 F3 PLG PRTN3
3 protein binding GO:0005515 10.03 CRP DLL1 F2 F3 HSPD1 MATK

Sources for Endocardium Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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