MCID: END074
MIFTS: 26

Endocardium Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Endocardium Disease

MalaCards integrated aliases for Endocardium Disease:

Name: Endocardium Disease 12 15
Abnormality of the Endocardium 30

Classifications:



External Ids:

Disease Ontology 12 DOID:0050825

Summaries for Endocardium Disease

Disease Ontology : 12 A heart disease that is located in the innermost layer of tissue that lines the chambers of the heart.

MalaCards based summary : Endocardium Disease, also known as abnormality of the endocardium, is related to endocarditis and endocardial fibroelastosis. An important gene associated with Endocardium Disease is TAZ (Tafazzin), and among its related pathways/superpathways are Complement and coagulation cascades and Formation of Fibrin Clot (Clotting Cascade). Affiliated tissues include the innermost layer of tissue and heart, and related phenotypes are cardiovascular system and cellular

Related Diseases for Endocardium Disease

Diseases related to Endocardium Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 endocarditis 31.9 CRP F2 HSPD1
2 endocardial fibroelastosis 11.1
3 gastrointestinal tuberculosis 10.4 CRP SMUG1
4 aortitis 10.4 CRP SMUG1
5 malignant otitis externa 10.4 CRP F2
6 bone epithelioid hemangioma 10.4 F3 SMUG1
7 partial motor epilepsy 10.4 F3 SMUG1
8 chronic thromboembolic pulmonary hypertension 10.4 CRP F2
9 abdominal tuberculosis 10.4 CRP F2
10 bursitis 10.4 CRP SH3BP5
11 anomalous left coronary artery from the pulmonary artery 10.4 SMUG1 TAZ
12 pulmonary artery leiomyosarcoma 10.4 PLG SMUG1
13 conjugate gaze palsy 10.3 F3 PLG
14 prothrombin deficiency 10.3 F2 F3
15 ischemic neuropathy 10.3 CRP F2
16 fournier gangrene 10.3 F2 F3
17 cerebral sinovenous thrombosis 10.3 F2 F3
18 qualitative platelet defect 10.3 F2 F3
19 cartilage disease 10.3 CRP SMUG1
20 hepatic tuberculosis 10.3 F2 SMUG1
21 salpingitis 10.3 CRP HSPD1
22 sagittal sinus thrombosis 10.3 F2 F3
23 eccrine adenocarcinoma 10.3 F2 SMUG1
24 non-secretory myeloma 10.3 FN1 SMUG1
25 alpha-2-plasmin inhibitor deficiency 10.3 F2 PLG
26 intracranial embolism 10.3 F2 PLG
27 alcohol-related birth defect 10.3 F2 F3
28 infective endocarditis 10.3 CRP F2 SH3BP5
29 tolosa-hunt syndrome 10.3 PRTN3 SMUG1
30 hantavirus pulmonary syndrome 10.3 F2 F3
31 von willebrand disease, type 1 10.3 F2 F3
32 peripheral vertigo 10.2 CRP F2 F3
33 analbuminemia 10.2 CRP F2 F3
34 cardiac rupture 10.2 CRP PRF1
35 granulomatous myositis 10.2 PRTN3 SMUG1
36 intermediate coronary syndrome 10.2 CRP F3 PLG
37 thrombocytosis 10.2 CRP F2 F3
38 pulmonary embolism 10.2 CRP F2 F3
39 peripheral vascular disease 10.2 CRP F2 F3
40 purpura 10.2 CRP F2 F3
41 gastrointestinal system disease 10.2 CRP F2 SMUG1
42 arteries, anomalies of 10.2 CRP F3 PLG
43 marantic endocarditis 10.2 F2 F3
44 cerebral falx meningioma 10.2 F2 F3 PLG
45 leech infestation 10.2 F2 F3 PLG
46 intestinal impaction 10.2 F2 F3 PLG
47 femoral neuropathy 10.2 F2 F3 PLG
48 anterior cranial fossa meningioma 10.2 F2 F3 PLG
49 korean hemorrhagic fever 10.2 F2 F3 PLG
50 nervous system disease 10.2 CRP PLG SMUG1

Graphical network of the top 20 diseases related to Endocardium Disease:



Diseases related to Endocardium Disease

Symptoms & Phenotypes for Endocardium Disease

MGI Mouse Phenotypes related to Endocardium Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.9 CRP DLL1 F2 F3 FN1 MRTFA
2 cellular MP:0005384 9.7 DLL1 F3 FN1 HSPD1 MRTFA MTM1
3 mortality/aging MP:0010768 9.36 DLL1 F2 F3 FN1 HSPD1 MRTFA

Drugs & Therapeutics for Endocardium Disease

Search Clinical Trials , NIH Clinical Center for Endocardium Disease

Genetic Tests for Endocardium Disease

Genetic tests related to Endocardium Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Endocardium 30

Anatomical Context for Endocardium Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Endocardium Disease:

20
The Innermost Layer Of Tissue

MalaCards organs/tissues related to Endocardium Disease:

42
Heart

Publications for Endocardium Disease

Variations for Endocardium Disease

Expression for Endocardium Disease

Search GEO for disease gene expression data for Endocardium Disease.

Pathways for Endocardium Disease

GO Terms for Endocardium Disease

Cellular components related to Endocardium Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 CRP F2 F3 FN1 HSPD1 PLG
2 endoplasmic reticulum lumen GO:0005788 9.62 F2 FN1 SERPINH1 SUMF2
3 extracellular region GO:0005576 9.61 CRP DLL1 F2 F3 FN1 PLG
4 blood microparticle GO:0072562 9.54 F2 FN1 PLG
5 membrane raft GO:0045121 9.43 DLL1 PRTN3 SERPINH1
6 collagen-containing extracellular matrix GO:0062023 9.02 F3 FN1 PLG PRTN3 SERPINH1

Biological processes related to Endocardium Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.8 DLL1 F2 FN1 MATK PRTN3
2 blood coagulation GO:0007596 9.62 F2 F3 PLG PRTN3
3 fibrinolysis GO:0042730 9.46 F2 PLG
4 protein maturation GO:0051604 9.43 HSPD1 SERPINH1
5 hemostasis GO:0007599 9.43 F2 F3 PLG
6 negative regulation of fibrinolysis GO:0051918 9.37 F2 PLG
7 positive regulation of skeletal muscle tissue growth GO:0048633 9.16 DLL1 MTM1
8 acute-phase response GO:0006953 9.13 CRP F2 FN1
9 interaction with symbiont GO:0051702 8.8 FN1 HSPD1 PLG

Molecular functions related to Endocardium Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.67 FN1 HSPD1 PLG PRTN3
2 chaperone binding GO:0051087 9.33 FN1 HSPD1 PLG
3 apolipoprotein binding GO:0034185 9.26 HSPD1 PLG
4 protease binding GO:0002020 8.96 F3 FN1
5 serine-type endopeptidase activity GO:0004252 8.92 F2 F3 PLG PRTN3
6 protein binding GO:0005515 10.2 CRP DLL1 F2 F3 FN1 HSPD1

Sources for Endocardium Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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