MCID: END074
MIFTS: 26

Endocardium Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Endocardium Disease

MalaCards integrated aliases for Endocardium Disease:

Name: Endocardium Disease 12 15
Abnormality of the Endocardium 30

Classifications:



External Ids:

Disease Ontology 12 DOID:0050825

Summaries for Endocardium Disease

Disease Ontology : 12 A heart disease that is located in the innermost layer of tissue that lines the chambers of the heart.

MalaCards based summary : Endocardium Disease, also known as abnormality of the endocardium, is related to endocarditis and endocardial fibroelastosis. An important gene associated with Endocardium Disease is TAZ (Tafazzin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Complement and coagulation cascades. Affiliated tissues include the innermost layer of tissue and heart, and related phenotypes are cardiovascular system and cellular

Related Diseases for Endocardium Disease

Diseases related to Endocardium Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 endocarditis 32.0 CRP F2 HSPD1
2 endocardial fibroelastosis 11.1
3 malignant otitis externa 10.4 CRP F2
4 chronic thromboembolic pulmonary hypertension 10.4 CRP F2
5 bursitis 10.4 CRP SH3BP5
6 abdominal tuberculosis 10.4 CRP F2
7 prothrombin deficiency 10.3 F2 F3
8 conjugate gaze palsy 10.3 F3 PLG
9 fournier gangrene 10.3 F2 F3
10 cerebral sinovenous thrombosis 10.3 F2 F3
11 ischemic neuropathy 10.3 CRP F2
12 qualitative platelet defect 10.3 F2 F3
13 salpingitis 10.3 CRP HSPD1
14 sagittal sinus thrombosis 10.3 F2 F3
15 alcohol-related birth defect 10.3 F2 F3
16 hantavirus pulmonary syndrome 10.3 F2 F3
17 alpha-2-plasmin inhibitor deficiency 10.3 F2 PLG
18 intracranial embolism 10.3 F2 PLG
19 infective endocarditis 10.3 CRP F2 SH3BP5
20 von willebrand disease, type 1 10.3 F2 F3
21 peripheral vertigo 10.3 CRP F2 F3
22 cardiac rupture 10.3 CRP PRF1
23 analbuminemia 10.3 CRP F2 F3
24 acute anterolateral myocardial infarction 10.2 ITGA2B PLG
25 lateral myocardial infarction 10.2 ITGA2B PLG
26 lemierre's syndrome 10.2 CRP F3 PLG
27 thrombocytosis 10.2 CRP F2 F3
28 pulmonary embolism 10.2 CRP F2 F3
29 marantic endocarditis 10.2 F2 F3
30 peripheral vascular disease 10.2 CRP F2 F3
31 cerebral falx meningioma 10.2 F2 F3 PLG
32 leech infestation 10.2 F2 F3 PLG
33 intestinal impaction 10.2 F2 F3 PLG
34 femoral neuropathy 10.2 F2 F3 PLG
35 anterior cranial fossa meningioma 10.2 F2 F3 PLG
36 korean hemorrhagic fever 10.2 F2 F3 PLG
37 squamous cell papilloma 10.2 F2 F3 HSPD1
38 vascular hemostatic disease 10.2 F2 F3
39 hepatic vascular disease 10.2 F2 F3 PLG
40 pulmonary artery disease 10.2 F2 F3 PLG
41 carotid artery thrombosis 10.2 F3 ITGA2B
42 vein disease 10.2 F2 F3 PLG
43 thrombophilia due to activated protein c resistance 10.2 F2 F3 PLG
44 arteriosclerosis 10.2 CRP F3 HSPD1
45 blood group, globoside system 10.2 PLG PRF1
46 inherited blood coagulation disease 10.2 F2 F3 ITGA2B
47 von willebrand disease, type 2 10.2 DLL1 F3 ITGA2B
48 thrombasthenia 10.1 F2 F3 ITGA2B
49 arteritic anterior ischemic optic neuropathy 10.1 CRP F2 PRTN3
50 rapidly progressive glomerulonephritis 10.1 CRP PRTN3

Graphical network of the top 20 diseases related to Endocardium Disease:



Diseases related to Endocardium Disease

Symptoms & Phenotypes for Endocardium Disease

MGI Mouse Phenotypes related to Endocardium Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.93 CRP DLL1 F2 F3 FN1 ITGA2B
2 cellular MP:0005384 9.7 DLL1 F3 FN1 HSPD1 ITGA2B MRTFA
3 reproductive system MP:0005389 9.23 F2 FN1 HSPD1 ITGA2B MTM1 PLG

Drugs & Therapeutics for Endocardium Disease

Search Clinical Trials , NIH Clinical Center for Endocardium Disease

Genetic Tests for Endocardium Disease

Genetic tests related to Endocardium Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Endocardium 30

Anatomical Context for Endocardium Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Endocardium Disease:

20
The Innermost Layer Of Tissue

MalaCards organs/tissues related to Endocardium Disease:

42
Heart

Publications for Endocardium Disease

Variations for Endocardium Disease

Expression for Endocardium Disease

Search GEO for disease gene expression data for Endocardium Disease.

Pathways for Endocardium Disease

GO Terms for Endocardium Disease

Cellular components related to Endocardium Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 CRP F2 F3 FN1 HSPD1 PLG
2 extracellular region GO:0005576 9.81 CRP DLL1 F2 F3 FN1 PLG
3 endoplasmic reticulum lumen GO:0005788 9.67 F2 FN1 SERPINH1 SUMF2
4 membrane raft GO:0045121 9.5 DLL1 PRTN3 SERPINH1
5 blood microparticle GO:0072562 9.26 F2 FN1 ITGA2B PLG
6 collagen-containing extracellular matrix GO:0062023 9.02 F3 FN1 PLG PRTN3 SERPINH1

Biological processes related to Endocardium Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.8 DLL1 F2 FN1 MATK PRTN3
2 platelet degranulation GO:0002576 9.63 FN1 ITGA2B PLG
3 blood coagulation GO:0007596 9.62 F2 F3 PLG PRTN3
4 fibrinolysis GO:0042730 9.48 F2 PLG
5 protein maturation GO:0051604 9.43 HSPD1 SERPINH1
6 hemostasis GO:0007599 9.43 F2 F3 PLG
7 negative regulation of fibrinolysis GO:0051918 9.37 F2 PLG
8 positive regulation of skeletal muscle tissue growth GO:0048633 9.16 DLL1 MTM1
9 acute-phase response GO:0006953 9.13 CRP F2 FN1
10 interaction with symbiont GO:0051702 8.8 FN1 HSPD1 PLG

Molecular functions related to Endocardium Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.67 FN1 HSPD1 PLG PRTN3
2 chaperone binding GO:0051087 9.33 FN1 HSPD1 PLG
3 apolipoprotein binding GO:0034185 9.26 HSPD1 PLG
4 protease binding GO:0002020 8.96 F3 FN1
5 serine-type endopeptidase activity GO:0004252 8.92 F2 F3 PLG PRTN3
6 protein binding GO:0005515 10.2 CRP DLL1 F2 F3 FN1 HSPD1

Sources for Endocardium Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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