MCID: END074
MIFTS: 26

Endocardium Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Endocardium Disease

MalaCards integrated aliases for Endocardium Disease:

Name: Endocardium Disease 12 15
Abnormality of the Endocardium 29

Classifications:



External Ids:

Disease Ontology 12 DOID:0050825

Summaries for Endocardium Disease

Disease Ontology : 12 A heart disease that is located in the innermost layer of tissue that lines the chambers of the heart.

MalaCards based summary : Endocardium Disease, also known as abnormality of the endocardium, is related to endocarditis and endocardial fibroelastosis. An important gene associated with Endocardium Disease is CRP (C-Reactive Protein), and among its related pathways/superpathways are Selenium Micronutrient Network and Overview of nanoparticle effects. Affiliated tissues include innermost layer of tissue, heart and bone, and related phenotypes are cardiovascular system and muscle

Related Diseases for Endocardium Disease

Diseases related to Endocardium Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 405)
# Related Disease Score Top Affiliating Genes
1 endocarditis 31.9 IL6 HSPD1 F2 CRP ALB
2 endocardial fibroelastosis 11.0
3 orbital osteomyelitis 10.5 F2 CRP
4 small intestine diverticulitis 10.5 F2 CRP
5 chronic duodenal ileus 10.5 CRP ALB
6 non-a-e hepatitis 10.5 F2 ALB
7 antipyrine metabolism 10.5 F2 ALB
8 purulent acute otitis media 10.5 PRTN3 CRP
9 hematocele of tunica vaginalis testis 10.5 F2 CRP
10 papillary adenofibroma 10.5 F3 F2
11 femoral neuropathy 10.5 F3 F2
12 anterior scleritis 10.5 PRTN3 CRP
13 frontal sinusitis 10.5 PRTN3 CRP
14 peptic ulcer perforation 10.5 CRP ALB
15 giant hemangioma 10.5 F3 F2
16 hemopneumothorax 10.5 F3 F2
17 subclavian steal syndrome 10.5 F3 CRP
18 dic in newborn 10.5 F3 F2
19 skeletal tuberculosis 10.5 CRP CFHR2
20 orbital plasma cell granuloma 10.5 PRTN3 CRP
21 inflammatory bowel disease 21 10.5 SERPINH1 MTM1
22 bicipital tenosynovitis 10.5 PRTN3 CRP
23 multiple cranial nerve palsy 10.5 PRTN3 CRP
24 posterior scleritis 10.5 PRTN3 CRP
25 tolosa-hunt syndrome 10.5 PRTN3 CRP
26 cerebral falx meningioma 10.5 F3 F2
27 tuberculous peritonitis 10.5 CRP ALB
28 achenbach syndrome 10.5 F3 F2 CRP
29 subdural empyema 10.5 F2 CRP
30 renal pelvis squamous cell carcinoma 10.5 F3 F2 CRP
31 synovial angioma 10.5 F3 F2 CRP
32 acalculous cholecystitis 10.5 F2 CRP ALB
33 emphysematous cholecystitis 10.5 F3 F2 CRP
34 splenic abscess 10.5 F2 CRP ALB
35 subacute bacterial endocarditis 10.5 SIGLEC5 PRTN3 CRP
36 ascending cholangitis 10.5 F2 CRP ALB
37 cavernous sinus thrombosis 10.5 F3 F2 CRP
38 lemierre's syndrome 10.5 F3 F2 CRP
39 acute cor pulmonale 10.5 F3 F2 CRP
40 paralytic ileus 10.5 F2 CRP ALB
41 intracranial sinus thrombosis 10.5 F3 F2 CRP
42 hemopericardium 10.5 F3 F2 CRP
43 common bile duct disease 10.5 F2 CRP ALB
44 ethmoid sinusitis 10.5 PRTN3 CRP
45 abdominal tuberculosis 10.5 F2 CRP ALB
46 cold agglutinin disease 10.5 IL6 CRP
47 critical illness polyneuropathy 10.5 F3 CRP ALB
48 kwashiorkor 10.5 F2 CRP ALB
49 aspiration pneumonitis 10.5 F3 CRP ALB
50 chronic orbital inflammation 10.5 PRTN3 CRP

Graphical network of the top 20 diseases related to Endocardium Disease:



Diseases related to Endocardium Disease

Symptoms & Phenotypes for Endocardium Disease

MGI Mouse Phenotypes related to Endocardium Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 ALB CRP F2 F3 FN1 HSPD1
2 muscle MP:0005369 9.23 ALB F2 F3 FN1 HSPD1 IL6

Drugs & Therapeutics for Endocardium Disease

Search Clinical Trials , NIH Clinical Center for Endocardium Disease

Genetic Tests for Endocardium Disease

Genetic tests related to Endocardium Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Endocardium 29

Anatomical Context for Endocardium Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Endocardium Disease:

19
Innermost Layer Of Tissue

MalaCards organs/tissues related to Endocardium Disease:

40
Heart, Bone, Kidney, Lung, Liver, Skin, Eye

Publications for Endocardium Disease

Articles related to Endocardium Disease:

# Title Authors PMID Year
1
The fetal heart: a practical sonographic approach. 61
8845190 1996

Variations for Endocardium Disease

Expression for Endocardium Disease

Search GEO for disease gene expression data for Endocardium Disease.

Pathways for Endocardium Disease

Pathways related to Endocardium Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.59 IL6 F2 CRP ALB
2 10.08 IL6 FN1 CRP

GO Terms for Endocardium Disease

Cellular components related to Endocardium Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.65 SERPINH1 PRTN3 FN1 F3 F2
2 extracellular space GO:0005615 9.65 TST SERPINH1 PRTN3 IL6 HSPD1 FN1
3 endoplasmic reticulum lumen GO:0005788 9.55 SERPINH1 IL6 FN1 F2 ALB
4 extracellular region GO:0005576 9.4 PRTN3 PRF1 PLGLB2 PLGLB1 IL6 FN1

Biological processes related to Endocardium Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.77 PPP3CA IL6 FN1 F3 CRP
2 cellular protein metabolic process GO:0044267 9.56 IL6 FN1 F2 ALB
3 cytolysis by host of symbiont cells GO:0051838 9.32 F2 CFHR2
4 negative regulation of lipid storage GO:0010888 9.16 IL6 CRP
5 interaction with symbiont GO:0051702 8.96 HSPD1 FN1
6 acute-phase response GO:0006953 8.92 IL6 FN1 F2 CRP

Molecular functions related to Endocardium Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.1 PRTN3 PLGLB2 PLGLB1 F3 F2 APEH

Sources for Endocardium Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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