MCID: END074
MIFTS: 25

Endocardium Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Endocardium Disease

MalaCards integrated aliases for Endocardium Disease:

Name: Endocardium Disease 12 15
Abnormality of the Endocardium 29

Classifications:



External Ids:

Disease Ontology 12 DOID:0050825

Summaries for Endocardium Disease

Disease Ontology : 12 A heart disease that is located in the innermost layer of tissue that lines the chambers of the heart.

MalaCards based summary : Endocardium Disease, also known as abnormality of the endocardium, is related to endocarditis and endocardial fibroelastosis. An important gene associated with Endocardium Disease is TAZ (Tafazzin), and among its related pathways/superpathways are Complement and coagulation cascades and Formation of Fibrin Clot (Clotting Cascade). Affiliated tissues include heart and innermost layer of tissue, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

Related Diseases for Endocardium Disease

Diseases related to Endocardium Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 endocarditis 32.3 HSPD1 F2 CRP
2 endocardial fibroelastosis 11.2
3 cryofibrinogenemia 10.7 FN1 CD40LG
4 malignant otitis externa 10.6 F2 CRP
5 heparin-induced thrombocytopenia 10.6 F3 CD40LG
6 secondary syphilis 10.6 FN1 CD40LG
7 chronic thromboembolic pulmonary hypertension 10.6 F2 CRP
8 abdominal tuberculosis 10.6 F2 CRP
9 salpingitis 10.5 HSPD1 CRP
10 prothrombin deficiency 10.5 F3 F2
11 cerebral sinovenous thrombosis 10.5 F3 F2
12 conjugate gaze palsy 10.5 PLG F3
13 ischemic neuropathy 10.5 F2 CRP
14 qualitative platelet defect 10.5 F3 F2
15 sagittal sinus thrombosis 10.5 F3 F2
16 catastrophic antiphospholipid syndrome 10.4 F3 CD40LG
17 intracranial embolism 10.4 PLG F2
18 pelvic inflammatory disease 10.4 HSPD1 CRP CD40LG
19 peripheral vertigo 10.4 F3 F2 CRP
20 lyme disease 10.4 HSPD1 CRP CD40LG
21 fournier gangrene 10.4 F3 F2 CD40LG
22 analbuminemia 10.4 F3 F2 CRP
23 alpha-2-plasmin inhibitor deficiency 10.4 PLG F2
24 thrombocytosis 10.4 F3 F2 CRP
25 pulmonary embolism 10.4 F3 F2 CRP
26 peripheral vascular disease 10.4 F3 F2 CRP
27 hantavirus pulmonary syndrome 10.3 F3 F2
28 purpura 10.3 F3 F2 CRP
29 lemierre's syndrome 10.3 PLG F3 CRP
30 intermediate coronary syndrome 10.3 PLG F3 CRP
31 antiphospholipid syndrome 10.3 F3 F2 CD40LG
32 alcohol-related birth defect 10.3 F3 F2
33 squamous cell papilloma 10.3 HSPD1 F3 F2
34 cardiac rupture 10.3 PRF1 CRP
35 von willebrand disease, type 1 10.3 F3 F2
36 cerebral falx meningioma 10.3 PLG F3 F2
37 intestinal impaction 10.3 PLG F3 F2
38 leech infestation 10.3 PLG F3 F2
39 femoral neuropathy 10.3 PLG F3 F2
40 arteries, anomalies of 10.3 PLG F3 CRP
41 anterior cranial fossa meningioma 10.3 PLG F3 F2
42 korean hemorrhagic fever 10.3 PLG F3 F2
43 pulmonary artery disease 10.3 PLG F3 F2
44 hepatic vascular disease 10.2 PLG F3 F2
45 vasculitis 10.2 PRTN3 CRP CD40LG
46 vein disease 10.2 PLG F3 F2
47 blood coagulation disease 10.2 PLG F3 F2
48 erysipeloid 10.2 PPP3CA PLG
49 thrombophilia due to activated protein c resistance 10.2 PLG F3 F2
50 arteriosclerosis 10.2 HSPD1 F3 CRP

Graphical network of the top 20 diseases related to Endocardium Disease:



Diseases related to Endocardium Disease

Symptoms & Phenotypes for Endocardium Disease

GenomeRNAi Phenotypes related to Endocardium Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00151-A-1 9.02 F2 PLXDC1 SERPINH1 SPESP1
2 Decreased homologous recombination repair frequency GR00151-A-2 9.02 SERPINH1

MGI Mouse Phenotypes related to Endocardium Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.23 CD40LG CRP DLL1 F2 F3 FN1
2 growth/size/body region MP:0005378 10.18 DLL1 F2 F3 FN1 HSPD1 KCNJ13
3 cellular MP:0005384 10.17 CD40LG DLL1 F3 FN1 HSPD1 MRTFA
4 homeostasis/metabolism MP:0005376 10.11 CD40LG CRP DLL1 F2 F3 FN1
5 mortality/aging MP:0010768 10.07 CD40LG DLL1 F2 F3 FN1 HSPD1
6 immune system MP:0005387 10.02 CD40LG CRP DLL1 F2 F3 FN1
7 muscle MP:0005369 9.7 DLL1 F3 FN1 HSPD1 MRTFA MTM1
8 nervous system MP:0003631 9.7 CD40LG DLL1 F2 F3 FN1 HSPD1
9 reproductive system MP:0005389 9.28 CD40LG F2 FN1 HSPD1 MTM1 PLG

Drugs & Therapeutics for Endocardium Disease

Search Clinical Trials , NIH Clinical Center for Endocardium Disease

Genetic Tests for Endocardium Disease

Genetic tests related to Endocardium Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Endocardium 29

Anatomical Context for Endocardium Disease

MalaCards organs/tissues related to Endocardium Disease:

41
Heart

The Foundational Model of Anatomy Ontology organs/tissues related to Endocardium Disease:

19
Innermost Layer Of Tissue

Publications for Endocardium Disease

Articles related to Endocardium Disease:

# Title Authors PMID Year
1
The fetal heart: a practical sonographic approach. 38
8845190 1996

Variations for Endocardium Disease

Expression for Endocardium Disease

Search GEO for disease gene expression data for Endocardium Disease.

Pathways for Endocardium Disease

GO Terms for Endocardium Disease

Cellular components related to Endocardium Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 SERPINH1 PRTN3 PLG HSPD1 FN1 F3
2 collagen-containing extracellular matrix GO:0062023 9.55 SERPINH1 PRTN3 PLG FN1 F3
3 membrane raft GO:0045121 9.43 SERPINH1 PRTN3 DLL1
4 extracellular region GO:0005576 9.32 PRTN3 PRF1 PLXDC1 PLG FN1 F3
5 plasma membrane GO:0005886 10.06 PRTN3 PRF1 PPP3CA PLXDC1 PLG MTM1

Biological processes related to Endocardium Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.62 PRTN3 PLG F3 F2
2 positive regulation of interleukin-10 production GO:0032733 9.46 HSPD1 CD40LG
3 fibrinolysis GO:0042730 9.43 PLG F2
4 hemostasis GO:0007599 9.43 PLG F3 F2
5 protein maturation GO:0051604 9.4 SERPINH1 HSPD1
6 negative regulation of fibrinolysis GO:0051918 9.37 PLG F2
7 positive regulation of skeletal muscle tissue growth GO:0048633 9.16 MTM1 DLL1
8 acute-phase response GO:0006953 9.13 FN1 F2 CRP
9 interaction with symbiont GO:0051702 8.8 PLG HSPD1 FN1

Molecular functions related to Endocardium Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.77 PRF1 PPP3CA F2 DLL1 CRP
2 chaperone binding GO:0051087 9.43 PLG HSPD1 FN1
3 apolipoprotein binding GO:0034185 9.32 PLG HSPD1
4 serine-type endopeptidase activity GO:0004252 9.26 PRTN3 PLG F3 F2
5 protease binding GO:0002020 9.16 FN1 F3
6 enzyme binding GO:0019899 9.02 PRTN3 PPP3CA PLG HSPD1 FN1

Sources for Endocardium Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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