MCID: END075
MIFTS: 38

Endocervical Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Endocervical Adenocarcinoma

MalaCards integrated aliases for Endocervical Adenocarcinoma:

Name: Endocervical Adenocarcinoma 12 15 73
Endocervical Carcinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050940
UMLS 73 C1263762

Summaries for Endocervical Adenocarcinoma

Disease Ontology : 12 An endocervical carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Endocervical Adenocarcinoma, also known as endocervical carcinoma, is related to vulval paget's disease and female reproductive endometrioid cancer. An important gene associated with Endocervical Adenocarcinoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Oncogene Induced Senescence. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include cervix, testes and ovary, and related phenotypes are cardiovascular system and cellular

Related Diseases for Endocervical Adenocarcinoma

Diseases related to Endocervical Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 251)
# Related Disease Score Top Affiliating Genes
1 vulval paget's disease 30.1 CDKN2A KRT20 KRT7
2 female reproductive endometrioid cancer 29.9 KRT7 TP53
3 cervix small cell carcinoma 29.8 CDKN2A TP53
4 endometrial adenocarcinoma 29.4 CDKN2A KRT7 TP53
5 small cell carcinoma 29.1 KRT20 KRT7 TP53
6 ovarian cancer 1 29.0 KRT7 PAX8 TP53
7 mucinous adenocarcinoma 29.0 CDKN2A CDX2 KRT20 KRT7
8 teratoma 28.8 CDX2 KRT7 TP53
9 adenocarcinoma in situ 28.3 CDKN2A CDX2 KRT20 KRT7 PAX2 PAX8
10 cystic teratoma 27.2 CDX2 KRT20 KRT7 MUC6 TP53
11 malignant peritoneal mesothelioma 10.8 CDKN2A VIM
12 ameloblastic carcinoma 10.8 CDKN2A VIM
13 inverted transitional papilloma 10.8 CDKN2A KRT7
14 endocervicitis 10.7
15 adenocarcinoma 10.7
16 pleomorphic liposarcoma 10.7 CDKN2A VIM
17 adenoid basal cell carcinoma 10.7 CDKN2A KRT7
18 parachordoma 10.7 KRT7 VIM
19 malignant mixed mullerian tumor 10.7 KRT7 VIM
20 nodular hidradenoma 10.7 KRT7 VIM
21 papillary adenoma 10.7 KRT7 VIM
22 benign metastasizing leiomyoma 10.7 KRT7 VIM
23 monophasic synovial sarcoma 10.7 KRT7 VIM
24 well-differentiated liposarcoma 10.7 CDKN2A KRT7
25 metanephric adenoma 10.7 KRT7 VIM
26 adenomatoid tumor 10.7 KRT7 VIM
27 hidradenoma 10.7 KRT7 VIM
28 nasal cavity squamous cell carcinoma 10.7 CDKN2A KRT7
29 renal adenoma 10.6 KRT7 PAX2
30 spindle cell sarcoma 10.6 KRT7 VIM
31 cystic basal cell carcinoma 10.6 KRT20 KRT7
32 seminal vesicle adenocarcinoma 10.6 KRT20 KRT7
33 transverse colon cancer 10.6 KRT20 KRT7
34 ovarian large-cell neuroendocrine carcinoma 10.6 KRT20 KRT7
35 eyelid neoplasm 10.6 KRT20 KRT7
36 malignant syringoma 10.6 KRT20 KRT7
37 endodermal sinus tumor 10.6 KRT7 VIM
38 krukenberg carcinoma 10.6 KRT20 KRT7
39 large intestine adenocarcinoma 10.6 KRT20 KRT7
40 linitis plastica 10.6 KRT20 KRT7
41 lung acinar adenocarcinoma 10.6 KRT20 KRT7
42 small cell carcinoma of the bladder 10.6 KRT20 KRT7
43 intratubular embryonal carcinoma 10.6 KRT20 KRT7
44 meibomian cyst 10.6 KRT20 KRT7
45 bladder lymphoma 10.6 KRT20 KRT7
46 chondromyxoid fibroma 10.5 CDKN2A VIM
47 paget disease, extramammary 10.5 KRT20 KRT7
48 prostatic acinar adenocarcinoma 10.5 KRT20 PAX2
49 endosalpingiosis 10.5 KRT7 PAX8
50 renal pelvis adenocarcinoma 10.5 KRT7 PAX8

Graphical network of the top 20 diseases related to Endocervical Adenocarcinoma:



Diseases related to Endocervical Adenocarcinoma

Symptoms & Phenotypes for Endocervical Adenocarcinoma

MGI Mouse Phenotypes related to Endocervical Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 CDKN2A CDX2 PAX2 PAX8 TP53 VIM
2 cellular MP:0005384 9.7 CDKN2A CDX2 KRT7 PAX2 PAX8 TP53
3 embryo MP:0005380 9.43 PAX8 TP53 VIM CDKN2A CDX2 PAX2
4 reproductive system MP:0005389 9.1 CDKN2A CDX2 PAX2 PAX8 TP53 VIM

Drugs & Therapeutics for Endocervical Adenocarcinoma

Drugs for Endocervical Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Human Papilloma Virus (HPV) Vaccine Efficacy Trial Against Cervical Pre-cancer in Young Adults With GlaxoSmithKline (GSK) Biologicals HPV-16/18 Completed NCT00122681 Phase 3

Search NIH Clinical Center for Endocervical Adenocarcinoma

Genetic Tests for Endocervical Adenocarcinoma

Anatomical Context for Endocervical Adenocarcinoma

MalaCards organs/tissues related to Endocervical Adenocarcinoma:

41
Cervix, Testes, Ovary, Thyroid, Lymph Node, Uterus

Publications for Endocervical Adenocarcinoma

Articles related to Endocervical Adenocarcinoma:

(show top 50) (show all 78)
# Title Authors Year
1
Gastric-type Endocervical Adenocarcinoma Involving the Endometrium and Clinically Mimicking Endometrial Neoplasia: A Diagnostic Challenge. ( 29683820 )
2018
2
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix. ( 29135516 )
2018
3
Pattern based classification of endocervical adenocarcinoma: a review. ( 29241973 )
2018
4
International Endocervical Adenocarcinoma Criteria and Classification: Validation and Interobserver Reproducibility. ( 29877920 )
2018
5
Gastric type mucinous endocervical adenocarcinoma of the uterine cervix: very rare and interesting case. ( 29372165 )
2018
6
Role of Lymphovascular Invasion in Pattern C Invasive Endocervical Adenocarcinoma. ( 28614201 )
2017
7
Endocervical Adenocarcinoma With Morphologic Features of Both Usual and Gastric Types: Clinicopathologic and Immunohistochemical Analyses and High-risk HPV Detection by In Situ Hybridization. ( 28296678 )
2017
8
Metastatic Endocervical Adenocarcinoma in a Mature Cystic Teratoma: A Case of a Tumor-to-Tumor Metastasis. ( 29140879 )
2017
9
Genomic abnormalities in invasive endocervical adenocarcinoma correlate with pattern of invasion: biologic and clinical implications. ( 28731050 )
2017
10
Architectural overlap between benign endocervix and pattern-A endocervical adenocarcinoma: Are all pattern-A tumors invasive? ( 28554747 )
2017
11
A case of endocervical adenocarcinoma detected 16 months after vaginal delivery. ( 27525079 )
2016
12
Detection of in situ and invasive endocervical adenocarcinoma on ThinPrep Pap Test: Morphologic analysis of false negative cases. ( 28105064 )
2016
13
Pattern classification of endocervical adenocarcinoma: reproducibility and review of criteria. ( 27255163 )
2016
14
Pattern-based classification of invasive endocervical adenocarcinoma, depth of invasion measurement and distinction from adenocarcinoma in situ: interobserver variation among gynecologic pathologists. ( 27174588 )
2016
15
Endocervical adenocarcinoma: selected diagnostic challenges. ( 26715171 )
2016
16
Cytology of minimal deviation endocervical adenocarcinoma (adenoma malignum) on a ThinPrep Pap test. ( 26991477 )
2016
17
New pattern-based personalized risk stratification system for endocervical adenocarcinoma with important clinical implications and surgical outcome. ( 27016227 )
2016
18
Possible relation between borderline ovarian cancer and endocervical adenocarcinoma: case report. ( 27172757 )
2016
19
Endocervical adenocarcinoma in situ presenting in fundal endometrial polyp: the mother of all skip lesions. ( 25844546 )
2015
20
Cytological variations and typical diagnostic features of endocervical adenocarcinoma in situ: A retrospective study of 74 cases. ( 25972909 )
2015
21
Application of a Pattern-based Classification System for Invasive Endocervical Adenocarcinoma in Cervical Biopsy, Cone and Loop Electrosurgical Excision (LEEP) Material: Pattern on Cone and LEEP is predictive of Pattern in the Overall Tumor. ( 26630232 )
2015
22
Advanced endocervical adenocarcinoma metastatic to the ovary presenting as primary ovarian cancer. ( 25951731 )
2015
23
Gastric-type Endocervical Adenocarcinoma: An Aggressive Tumor With Unusual Metastatic Patterns and Poor Prognosis. ( 26457350 )
2015
24
Invasive Endocervical Adenocarcinoma: A New Pattern-based Classification System With Important Clinical Significance. ( 25724003 )
2015
25
Dysregulation of CDK inhibitors and p53 in HPV-negative endocervical adenocarcinoma. ( 25675191 )
2015
26
Human Papillomavirus-Related Ovarian Metastasis With Endocervical Adenocarcinoma: Report of 2 Cases and Review of Literature. ( 26360235 )
2015
27
A Case of HPV-negative Intestinal-type Endocervical Adenocarcinoma In Situ With Coexisting Multifocal Intestinal and Gastric Metaplasia. ( 24418863 )
2014
28
Direct sampling of metastatic ovarian carcinoma masquerading as endocervical adenocarcinoma in liquid-based cytology cervical sample. ( 25538388 )
2014
29
Interobserver Variability in the Application of a Proposed Histologic Subclassification of Endocervical Adenocarcinoma. ( 25188867 )
2014
30
Magnetic resonance appearance of gastric-type adenocarcinoma of the uterine cervix in comparison with that of usual-type endocervical adenocarcinoma: a pitfall of newly described unusual subtype of endocervical adenocarcinoma. ( 25188888 )
2014
31
Peritoneal metastases from mucinous endocervical adenocarcinoma. ( 26075991 )
2014
32
Numerous psammoma bodies in cervical cytology of high-grade endocervical adenocarcinoma. ( 23855933 )
2014
33
PAX8 and PAX2 expression in endocervical adenocarcinoma in situ and high-grade squamous dysplasia. ( 23202787 )
2013
34
Intestinal-type endocervical adenocarcinoma in situ: an immunophenotypically distinct subset of AIS affecting older women. ( 23552379 )
2013
35
Invasive endocervical adenocarcinoma: proposal for a new pattern-based classification system with significant clinical implications: a multi-institutional study. ( 24071876 )
2013
36
Are women with endocervical adenocarcinoma at risk for lynch syndrome? Evaluation of 101 cases including unusual subtypes and lower uterine segment tumors. ( 22833088 )
2012
37
Diffusion-weighted magnetic resonance imaging to detect synchronous uterine endometrial and endocervical adenocarcinoma. ( 22532917 )
2012
38
Mixed endocervical adenocarcinoma and high-grade neuroendocrine carcinoma of the cervix with ovarian metastasis of the former component: a report of 2 cases. ( 22833092 )
2012
39
Cytological screening of endocervical adenocarcinoma. ( 23244488 )
2012
40
Metastatic endocervical adenocarcinoma in a western lowland gorilla (Gorilla g. gorilla): no evidence of virus-induced carcinogenesis. ( 22273046 )
2012
41
Infection of a lymphocyst after pelvic lymph node dissection for endocervical adenocarcinoma. ( 22779981 )
2012
42
Endocervical adenocarcinoma - Proposal for a new histopathologic pattern-based classification system with significant clinical implications: A multi-institutional study. ( 24989540 )
2012
43
Correlation between invasive pattern and immunophenotypic alterations in endocervical adenocarcinoma. ( 21401700 )
2011
44
PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma. ( 20061933 )
2010
45
Papanicolaou tests associated with cervical mucosal endometriosis: an analysis of cellular features and comparison to endocervical adenocarcinoma in situ. ( 19937768 )
2010
46
Absence of high-risk human papillomavirus (HPV) detection in endocervical adenocarcinoma with gastric morphology and phenotype. ( 20829441 )
2010
47
Lymphatic vessel density as a prognostic marker in clinical stage I endocervical adenocarcinoma. ( 20567154 )
2010
48
Endocervical adenocarcinoma in situ with ovarian metastases: a unique variant with potential for long-term survival. ( 19952931 )
2010
49
Utility of p16 expression for distinction of uterine serous carcinomas from endometrial endometrioid and endocervical adenocarcinomas: immunohistochemical analysis of 201 cases. ( 19623034 )
2009
50
Performance of the cytologic examination for the diagnosis of endocervical adenocarcinoma in situ: cytologic-histologic correlation in 60 cases. ( 19798884 )
2009

Variations for Endocervical Adenocarcinoma

Expression for Endocervical Adenocarcinoma

Search GEO for disease gene expression data for Endocervical Adenocarcinoma.

Pathways for Endocervical Adenocarcinoma

Pathways related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.92 CDX2 PAX2 VIM
2 10.83 CDKN2A TP53
3 10.6 CDKN2A TP53
4
Show member pathways
10.5 CDKN2A TP53
5 10.16 PAX2 PAX8

GO Terms for Endocervical Adenocarcinoma

Cellular components related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 KRT20 KRT7 VIM

Biological processes related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 transcription by RNA polymerase II GO:0006366 9.89 CDX2 PAX2 PAX8 TP53
2 positive regulation of transcription, DNA-templated GO:0045893 9.88 CDKN2A CDX2 PAX2 PAX8 TP53
3 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.58 PAX2 PAX8
4 intermediate filament organization GO:0045109 9.58 KRT20 VIM
5 urogenital system development GO:0001655 9.57 PAX2 PAX8
6 mesonephros development GO:0001823 9.56 PAX2 PAX8
7 replicative senescence GO:0090399 9.55 CDKN2A TP53
8 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.54 PAX2 PAX8
9 pronephros development GO:0048793 9.52 PAX2 PAX8
10 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.51 PAX2 PAX8
11 metanephric epithelium development GO:0072207 9.49 PAX2 PAX8
12 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.46 PAX2 PAX8
13 metanephric nephron tubule formation GO:0072289 9.43 PAX2 PAX8
14 metanephric distal convoluted tubule development GO:0072221 9.4 PAX2 PAX8
15 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.37 PAX2 PAX8
16 pronephric field specification GO:0039003 9.32 PAX2 PAX8
17 positive regulation of metanephric DCT cell differentiation GO:2000594 9.26 PAX2 PAX8
18 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.16 PAX2 PAX8
19 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 8.96 PAX2 PAX8
20 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 8.62 PAX2 PAX8

Molecular functions related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 9.13 PAX2 PAX8 TP53
2 disordered domain specific binding GO:0097718 8.62 CDKN2A TP53

Sources for Endocervical Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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