MCID: END075
MIFTS: 39

Endocervical Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Endocervical Adenocarcinoma

MalaCards integrated aliases for Endocervical Adenocarcinoma:

Name: Endocervical Adenocarcinoma 12 15 74
Endocervical Carcinoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050940

Summaries for Endocervical Adenocarcinoma

Disease Ontology : 12 An endocervical carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Endocervical Adenocarcinoma, also known as endocervical carcinoma, is related to cervix small cell carcinoma and vulval paget's disease. An important gene associated with Endocervical Adenocarcinoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Cytoskeletal Signaling. The drugs Immunologic Factors and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include cervix, ovary and kidney, and related phenotypes are embryo and reproductive system

Related Diseases for Endocervical Adenocarcinoma

Diseases related to Endocervical Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 304)
# Related Disease Score Top Affiliating Genes
1 cervix small cell carcinoma 30.3 CDKN2A TP53
2 vulval paget's disease 30.1 CDKN2A KRT20 KRT7
3 mammary paget's disease 29.9 KRT20 KRT7 MUC1
4 adenocarcinoma in situ 29.7 CDKN2A CDX2 KRT20 KRT7 PAX2 PAX8
5 ovarian cancer 1 29.7 KRT7 PAX8 TP53
6 clear cell adenocarcinoma 29.7 KRT20 KRT7 PAX2 PAX8
7 appendix adenocarcinoma 29.7 CDX2 KRT20 KRT7
8 papilloma 29.7 CDKN2A KRT20 KRT7 TP53
9 endometrial cancer 29.7 CDKN2A KRT7 PAX8 TP53
10 small cell carcinoma 29.6 CDKN2A KRT20 KRT7 TP53
11 teratoma 29.6 CDX2 KRT7 TP53
12 cervical adenocarcinoma 29.5 CDKN2A CDX2 KRT20 KRT7 TP53
13 mucinous adenocarcinoma 29.0 CDKN2A CDX2 KRT20 KRT7 MUC1
14 cystic teratoma 28.7 CDX2 KRT20 KRT7 MUC6 TP53
15 adenocarcinoma 11.0
16 anal canal carcinoma 10.4 CDKN2A KRT7
17 acral lentiginous melanoma 10.4 CDKN2A VIM
18 ameloblastic carcinoma 10.4 CDKN2A VIM
19 adenoid basal cell carcinoma 10.4 CDKN2A KRT7
20 nasal cavity squamous cell carcinoma 10.4 CDKN2A KRT7
21 papillary adenoma 10.4 KRT7 VIM
22 fibrolamellar carcinoma 10.4 KRT7 VIM
23 metanephric adenoma 10.4 KRT7 VIM
24 adenomatoid tumor 10.4 KRT7 VIM
25 benign metastasizing leiomyoma 10.4 KRT7 VIM
26 large cell neuroendocrine carcinoma 10.4 KRT20 KRT7
27 large intestine adenocarcinoma 10.4 KRT20 KRT7
28 immune system organ benign neoplasm 10.4 KRT20 KRT7
29 bladder lymphoma 10.4 KRT20 KRT7
30 thymus lipoma 10.4 KRT20 KRT7
31 papillary transitional carcinoma 10.4 KRT20 KRT7
32 linitis plastica 10.4 KRT20 KRT7
33 infiltrative basal cell carcinoma 10.4 KRT20 KRT7
34 ovarian cystic teratoma 10.4 KRT20 KRT7
35 malignant syringoma 10.4 KRT20 KRT7
36 eyelid carcinoma 10.4 KRT20 KRT7
37 lung acinar adenocarcinoma 10.4 KRT20 KRT7
38 intratubular embryonal carcinoma 10.4 KRT20 KRT7
39 krukenberg carcinoma 10.3 KRT20 KRT7
40 meibomian cyst 10.3 KRT20 KRT7
41 small cell carcinoma of the bladder 10.3 KRT20 KRT7
42 sensory organ benign neoplasm 10.3 KRT7 PAX8
43 peritoneum cancer 10.3 KRT7 PAX8
44 collecting duct carcinoma 10.3 KRT7 PAX8
45 renal pelvis adenocarcinoma 10.3 KRT7 PAX8
46 deafness, autosomal dominant 10 10.3 PAX2 PAX8
47 urethral diverticulum 10.3 KRT7 PAX8
48 sarcomatoid mesothelioma 10.3 CDKN2A MUC1
49 hemangiopericytoma, malignant 10.3 MUC1 VIM
50 reticulum cell sarcoma 10.3 MUC1 VIM

Graphical network of the top 20 diseases related to Endocervical Adenocarcinoma:



Diseases related to Endocervical Adenocarcinoma

Symptoms & Phenotypes for Endocervical Adenocarcinoma

MGI Mouse Phenotypes related to Endocervical Adenocarcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.43 CDKN2A CDX2 PAX2 PAX8 TP53 VIM
2 reproductive system MP:0005389 9.1 CDKN2A CDX2 PAX2 PAX8 TP53 VIM

Drugs & Therapeutics for Endocervical Adenocarcinoma

Drugs for Endocervical Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 3
2 Vaccines Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Human Papilloma Virus (HPV) Vaccine Efficacy Trial Against Cervical Pre-cancer in Young Adults With GlaxoSmithKline (GSK) Biologicals HPV-16/18 Completed NCT00122681 Phase 3

Search NIH Clinical Center for Endocervical Adenocarcinoma

Genetic Tests for Endocervical Adenocarcinoma

Anatomical Context for Endocervical Adenocarcinoma

MalaCards organs/tissues related to Endocervical Adenocarcinoma:

42
Cervix, Ovary, Kidney, Thymus, Appendix, Liver, Prostate

Publications for Endocervical Adenocarcinoma

Articles related to Endocervical Adenocarcinoma:

(show top 50) (show all 118)
# Title Authors Year
1
Challenges in the Pap diagnosis of endocervical adenocarcinoma in situ. ( 31097290 )
2019
2
Gastric-type endocervical adenocarcinoma with uterine corpus involvement mimicking primary endometrial carcinoma. ( 31012190 )
2019
3
HPV DNA integration site as proof of the origin of ovarian metastasis from endocervical adenocarcinoma: three case reports. ( 31014281 )
2019
4
A case of gastric-type mucinous endocervical adenocarcinoma in presence of nabothian cysts. ( 30878235 )
2019
5
Clinical Outcomes of HPV-associated and Unassociated Endocervical Adenocarcinomas Categorized by the International Endocervical Adenocarcinoma Criteria and Classification (IECC). ( 30720532 )
2019
6
International Endocervical Adenocarcinoma Criteria and Classification (IECC): correlation with adverse clinicopathological features and patient outcome. ( 30679193 )
2019
7
Study of the revisited, revised, and expanded Silva pattern system for Chinese endocervical adenocarcinoma patients. ( 30218754 )
2019
8
International Endocervical Adenocarcinoma Criteria and Classification: Validation and Interobserver Reproducibility. ( 29877920 )
2019
9
Endocervical Adenocarcinoma In Situ Phenotype with Ovarian Metastasis. ( 30599504 )
2018
10
Independent validation of the prognostic significance of invasion patterns in endocervical adenocarcinoma: Pattern A predicts excellent survival. ( 30262404 )
2018
11
Metastatic Endocervical Adenocarcinoma in a Mature Cystic Teratoma: A Case of a Tumor-to-Tumor Metastasis. ( 29140879 )
2018
12
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix. ( 29135516 )
2018
13
Pattern based classification of endocervical adenocarcinoma: a review. ( 29241973 )
2018
14
Gastric type mucinous endocervical adenocarcinoma of the uterine cervix: very rare and interesting case. ( 29372165 )
2018
15
Gastric-type Endocervical Adenocarcinoma Involving the Endometrium and Clinically Mimicking Endometrial Neoplasia: A Diagnostic Challenge. ( 29683820 )
2018
16
Endocervical Adenocarcinoma With Morphologic Features of Both Usual and Gastric Types: Clinicopathologic and Immunohistochemical Analyses and High-risk HPV Detection by In Situ Hybridization. ( 28296678 )
2017
17
Architectural overlap between benign endocervix and pattern-A endocervical adenocarcinoma: Are all pattern-A tumors invasive? ( 28554747 )
2017
18
Role of Lymphovascular Invasion in Pattern C Invasive Endocervical Adenocarcinoma. ( 28614201 )
2017
19
Case 21-2017. A 28-Year-Old Pregnant Woman with Endocervical Carcinoma. ( 28700849 )
2017
20
Genomic abnormalities in invasive endocervical adenocarcinoma correlate with pattern of invasion: biologic and clinical implications. ( 28731050 )
2017
21
Pattern-based classification of invasive endocervical adenocarcinoma, depth of invasion measurement and distinction from adenocarcinoma in situ: interobserver variation among gynecologic pathologists. ( 27174588 )
2016
22
Cytology of minimal deviation endocervical adenocarcinoma (adenoma malignum) on a ThinPrep Pap test. ( 26991477 )
2016
23
Application of a Pattern-based Classification System for Invasive Endocervical Adenocarcinoma in Cervical Biopsy, Cone and Loop Electrosurgical Excision (LEEP) Material: Pattern on Cone and LEEP is Predictive of Pattern in the Overall Tumor. ( 26630232 )
2016
24
Endocervical adenocarcinoma: selected diagnostic challenges. ( 26715171 )
2016
25
New pattern-based personalized risk stratification system for endocervical adenocarcinoma with important clinical implications and surgical outcome. ( 27016227 )
2016
26
Possible relation between borderline ovarian cancer and endocervical adenocarcinoma: case report. ( 27172757 )
2016
27
Pattern classification of endocervical adenocarcinoma: reproducibility and review of criteria. ( 27255163 )
2016
28
A case of endocervical adenocarcinoma detected 16 months after vaginal delivery. ( 27525079 )
2016
29
Detection of in situ and invasive endocervical adenocarcinoma on ThinPrep Pap Test: Morphologic analysis of false negative cases. ( 28105064 )
2016
30
Endocervical adenocarcinoma in situ presenting in fundal endometrial polyp: the mother of all skip lesions. ( 25844546 )
2015
31
Cytological variations and typical diagnostic features of endocervical adenocarcinoma in situ: A retrospective study of 74 cases. ( 25972909 )
2015
32
Interobserver variability in the application of a proposed histologic subclassification of endocervical adenocarcinoma. ( 25188867 )
2015
33
Dysregulation of CDK inhibitors and p53 in HPV-negative endocervical adenocarcinoma. ( 25675191 )
2015
34
Invasive endocervical adenocarcinoma: a new pattern-based classification system with important clinical significance. ( 25724003 )
2015
35
Advanced endocervical adenocarcinoma metastatic to the ovary presenting as primary ovarian cancer. ( 25951731 )
2015
36
Human Papillomavirus-Related Ovarian Metastasis With Endocervical Adenocarcinoma: Report of 2 Cases and Review of Literature. ( 26360235 )
2015
37
Gastric-type Endocervical Adenocarcinoma: An Aggressive Tumor With Unusual Metastatic Patterns and Poor Prognosis. ( 26457350 )
2015
38
A case of HPV-negative intestinal-type endocervical adenocarcinoma in situ with coexisting multifocal intestinal and gastric metaplasia. ( 24418863 )
2014
39
Numerous psammoma bodies in cervical cytology of high-grade endocervical adenocarcinoma. ( 23855933 )
2014
40
Magnetic resonance appearance of gastric-type adenocarcinoma of the uterine cervix in comparison with that of usual-type endocervical adenocarcinoma: a pitfall of newly described unusual subtype of endocervical adenocarcinoma. ( 25188888 )
2014
41
Direct sampling of metastatic ovarian carcinoma masquerading as endocervical adenocarcinoma in liquid-based cytology cervical sample. ( 25538388 )
2014
42
Peritoneal metastases from mucinous endocervical adenocarcinoma. ( 26075991 )
2014
43
PAX8 and PAX2 expression in endocervical adenocarcinoma in situ and high-grade squamous dysplasia. ( 23202787 )
2013
44
Intestinal-type endocervical adenocarcinoma in situ: an immunophenotypically distinct subset of AIS affecting older women. ( 23552379 )
2013
45
Invasive endocervical adenocarcinoma: proposal for a new pattern-based classification system with significant clinical implications: a multi-institutional study. ( 24071876 )
2013
46
Metastatic endocervical adenocarcinoma in a western lowland gorilla (Gorilla g. gorilla): no evidence of virus-induced carcinogenesis. ( 22273046 )
2012
47
Diffusion-weighted magnetic resonance imaging to detect synchronous uterine endometrial and endocervical adenocarcinoma. ( 22532917 )
2012
48
Infection of a lymphocyst after pelvic lymph node dissection for endocervical adenocarcinoma. ( 22779981 )
2012
49
Are women with endocervical adenocarcinoma at risk for lynch syndrome? Evaluation of 101 cases including unusual subtypes and lower uterine segment tumors. ( 22833088 )
2012
50
Mixed endocervical adenocarcinoma and high-grade neuroendocrine carcinoma of the cervix with ovarian metastasis of the former component: a report of 2 cases. ( 22833092 )
2012

Variations for Endocervical Adenocarcinoma

Expression for Endocervical Adenocarcinoma

Search GEO for disease gene expression data for Endocervical Adenocarcinoma.

Pathways for Endocervical Adenocarcinoma

GO Terms for Endocervical Adenocarcinoma

Cellular components related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 KRT20 KRT7 VIM

Biological processes related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.89 CDKN2A CDX2 PAX2 PAX8 TP53
2 transcription by RNA polymerase II GO:0006366 9.6 CDX2 PAX2
3 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.59 PAX2 PAX8
4 intermediate filament organization GO:0045109 9.58 KRT20 VIM
5 urogenital system development GO:0001655 9.58 PAX2 PAX8
6 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.57 MUC1 TP53
7 mesonephros development GO:0001823 9.56 PAX2 PAX8
8 replicative senescence GO:0090399 9.55 CDKN2A TP53
9 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.54 PAX2 PAX8
10 pronephros development GO:0048793 9.52 PAX2 PAX8
11 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.51 PAX2 PAX8
12 metanephric epithelium development GO:0072207 9.48 PAX2 PAX8
13 metanephric distal convoluted tubule development GO:0072221 9.46 PAX2 PAX8
14 metanephric nephron tubule formation GO:0072289 9.43 PAX2 PAX8
15 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.4 PAX2 PAX8
16 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.37 PAX2 PAX8
17 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.32 PAX2 PAX8
18 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.26 PAX2 PAX8
19 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.16 PAX2 PAX8
20 positive regulation of metanephric DCT cell differentiation GO:2000594 8.96 PAX2 PAX8
21 pronephric field specification GO:0039003 8.62 PAX2 PAX8

Sources for Endocervical Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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