MCID: END075
MIFTS: 42

Endocervical Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Endocervical Adenocarcinoma

MalaCards integrated aliases for Endocervical Adenocarcinoma:

Name: Endocervical Adenocarcinoma 12 15 74
Endocervical Carcinoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050940

Summaries for Endocervical Adenocarcinoma

Disease Ontology : 12 An endocervical carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Endocervical Adenocarcinoma, also known as endocervical carcinoma, is related to cervix small cell carcinoma and vulval paget's disease. An important gene associated with Endocervical Adenocarcinoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include cervix, testes and lymph node, and related phenotypes are cellular and cardiovascular system

Related Diseases for Endocervical Adenocarcinoma

Diseases related to Endocervical Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 261)
# Related Disease Score Top Affiliating Genes
1 cervix small cell carcinoma 30.4 CDKN2A TP53
2 vulval paget's disease 30.1 CDKN2A KRT20 KRT7
3 ovarian cancer 1 29.9 KRT7 PAX8 TP53
4 adenocarcinoma in situ 29.9 CDKN2A CDX2 KRT20 KRT7 PAX2 PAX8
5 teratoma 29.8 CDX2 KRT7 TP53
6 small cell carcinoma 29.7 CDKN2A KRT20 KRT7 TP53
7 clear cell adenocarcinoma 29.7 KRT20 KRT7 PAX2 PAX8
8 mucinous adenocarcinoma 29.6 CDKN2A CDX2 KRT20 KRT7
9 papilloma 29.3 CDKN1A CDKN2A KRT20 KRT7 TP53
10 cervical adenocarcinoma 28.9 CDKN1A CDKN2A CDX2 KRT20 KRT7 TP53
11 cystic teratoma 28.7 CDX2 KRT20 KRT7 MUC6 TP53
12 adenocarcinoma 11.0
13 pleomorphic liposarcoma 10.4 CDKN2A VIM
14 acral lentiginous melanoma 10.4 CDKN2A VIM
15 anal canal carcinoma 10.4 CDKN2A KRT7
16 ameloblastic carcinoma 10.4 CDKN2A VIM
17 adenoid basal cell carcinoma 10.4 CDKN2A KRT7
18 nasal cavity squamous cell carcinoma 10.4 CDKN2A KRT7
19 nodular hidradenoma 10.4 KRT7 VIM
20 papillary adenoma 10.4 KRT7 VIM
21 hidradenoma 10.4 KRT7 VIM
22 well-differentiated liposarcoma 10.4 CDKN2A KRT7
23 spindle cell sarcoma 10.4 KRT7 VIM
24 fibrolamellar carcinoma 10.4 KRT7 VIM
25 monophasic synovial sarcoma 10.4 KRT7 VIM
26 metanephric adenoma 10.4 KRT7 VIM
27 adenomatoid tumor 10.4 KRT7 VIM
28 benign metastasizing leiomyoma 10.4 KRT7 VIM
29 paget disease, extramammary 10.4 KRT20 KRT7
30 large cell neuroendocrine carcinoma 10.4 KRT20 KRT7
31 immune system organ benign neoplasm 10.4 KRT20 KRT7
32 bladder lymphoma 10.4 KRT20 KRT7
33 thymus lipoma 10.4 KRT20 KRT7
34 dendritic cell tumor 10.4 KRT20 VIM
35 mammary paget's disease 10.4 KRT20 KRT7
36 infiltrative basal cell carcinoma 10.4 KRT20 KRT7
37 ovarian cystic teratoma 10.4 KRT20 KRT7
38 cystadenofibroma 10.3 KRT20 KRT7
39 lymphoepithelioma-like carcinoma 10.3 KRT20 KRT7
40 pancreatic mucinous cystadenoma 10.3 KRT20 KRT7
41 meibomian cyst 10.3 KRT20 KRT7
42 peritoneum cancer 10.3 KRT7 PAX8
43 collecting duct carcinoma 10.3 KRT7 PAX8
44 pre-malignant neoplasm 10.3 CDKN2A TP53
45 thyroid lymphoma 10.3 CDKN2A TP53
46 tongue disease 10.3 CDKN2A TP53
47 anogenital venereal wart 10.3 CDKN2A TP53
48 megaesophagus 10.3 CDKN2A TP53
49 squamous cell papilloma 10.3 CDKN2A TP53
50 penile disease 10.3 CDKN2A TP53

Graphical network of the top 20 diseases related to Endocervical Adenocarcinoma:



Diseases related to Endocervical Adenocarcinoma

Symptoms & Phenotypes for Endocervical Adenocarcinoma

MGI Mouse Phenotypes related to Endocervical Adenocarcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 CDKN1A CDKN2A CDX2 KRT7 PAX2 PAX8
2 cardiovascular system MP:0005385 9.95 CDKN1A CDKN2A CDX2 PAX2 PAX8 TP53
3 embryo MP:0005380 9.87 CDKN1A CDKN2A CDX2 PAX2 PAX8 TP53
4 endocrine/exocrine gland MP:0005379 9.73 CDKN1A CDKN2A CDX2 PAX2 PAX8 TP53
5 renal/urinary system MP:0005367 9.55 CDKN1A KRT7 PAX2 PAX8 TP53
6 reproductive system MP:0005389 9.5 CDKN1A CDKN2A CDX2 PAX2 PAX8 TP53
7 vision/eye MP:0005391 9.1 CDKN1A CDKN2A PAX2 PAX8 TP53 VIM

Drugs & Therapeutics for Endocervical Adenocarcinoma

Drugs for Endocervical Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 3
2 Immunologic Factors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Human Papilloma Virus (HPV) Vaccine Efficacy Trial Against Cervical Pre-cancer in Young Adults With GlaxoSmithKline (GSK) Biologicals HPV-16/18 Completed NCT00122681 Phase 3

Search NIH Clinical Center for Endocervical Adenocarcinoma

Genetic Tests for Endocervical Adenocarcinoma

Anatomical Context for Endocervical Adenocarcinoma

MalaCards organs/tissues related to Endocervical Adenocarcinoma:

42
Cervix, Testes, Lymph Node, Ovary, Heart

Publications for Endocervical Adenocarcinoma

Articles related to Endocervical Adenocarcinoma:

(show top 50) (show all 108)
# Title Authors Year
1
A case of gastric-type mucinous endocervical adenocarcinoma in presence of nabothian cysts. ( 30878235 )
2019
2
Clinical Outcomes of HPV-associated and Unassociated Endocervical Adenocarcinomas Categorized by the International Endocervical Adenocarcinoma Criteria and Classification (IECC). ( 30720532 )
2019
3
International Endocervical Adenocarcinoma Criteria and Classification (IECC): correlation with adverse clinicopathological features and patient outcome. ( 30679193 )
2019
4
Gastric-type Endocervical Adenocarcinoma Involving the Endometrium and Clinically Mimicking Endometrial Neoplasia: A Diagnostic Challenge. ( 29683820 )
2018
5
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix. ( 29135516 )
2018
6
Pattern based classification of endocervical adenocarcinoma: a review. ( 29241973 )
2018
7
International Endocervical Adenocarcinoma Criteria and Classification: Validation and Interobserver Reproducibility. ( 29877920 )
2018
8
Gastric type mucinous endocervical adenocarcinoma of the uterine cervix: very rare and interesting case. ( 29372165 )
2018
9
Endocervical Adenocarcinoma In Situ Phenotype with Ovarian Metastasis. ( 30599504 )
2018
10
Independent validation of the prognostic significance of invasion patterns in endocervical adenocarcinoma: Pattern A predicts excellent survival. ( 30262404 )
2018
11
Study of the revisited, revised, and expanded Silva pattern system for Chinese Endocervical adenocarcinoma patients. ( 30218754 )
2018
12
Role of Lymphovascular Invasion in Pattern C Invasive Endocervical Adenocarcinoma. ( 28614201 )
2017
13
Endocervical Adenocarcinoma With Morphologic Features of Both Usual and Gastric Types: Clinicopathologic and Immunohistochemical Analyses and High-risk HPV Detection by In Situ Hybridization. ( 28296678 )
2017
14
Metastatic Endocervical Adenocarcinoma in a Mature Cystic Teratoma: A Case of a Tumor-to-Tumor Metastasis. ( 29140879 )
2017
15
Genomic abnormalities in invasive endocervical adenocarcinoma correlate with pattern of invasion: biologic and clinical implications. ( 28731050 )
2017
16
Architectural overlap between benign endocervix and pattern-A endocervical adenocarcinoma: Are all pattern-A tumors invasive? ( 28554747 )
2017
17
A case of endocervical adenocarcinoma detected 16 months after vaginal delivery. ( 27525079 )
2016
18
Detection of in situ and invasive endocervical adenocarcinoma on ThinPrep Pap Test: Morphologic analysis of false negative cases. ( 28105064 )
2016
19
Pattern classification of endocervical adenocarcinoma: reproducibility and review of criteria. ( 27255163 )
2016
20
Pattern-based classification of invasive endocervical adenocarcinoma, depth of invasion measurement and distinction from adenocarcinoma in situ: interobserver variation among gynecologic pathologists. ( 27174588 )
2016
21
Endocervical adenocarcinoma: selected diagnostic challenges. ( 26715171 )
2016
22
Cytology of minimal deviation endocervical adenocarcinoma (adenoma malignum) on a ThinPrep Pap test. ( 26991477 )
2016
23
New pattern-based personalized risk stratification system for endocervical adenocarcinoma with important clinical implications and surgical outcome. ( 27016227 )
2016
24
Possible relation between borderline ovarian cancer and endocervical adenocarcinoma: case report. ( 27172757 )
2016
25
Endocervical adenocarcinoma in situ presenting in fundal endometrial polyp: the mother of all skip lesions. ( 25844546 )
2015
26
Cytological variations and typical diagnostic features of endocervical adenocarcinoma in situ: A retrospective study of 74 cases. ( 25972909 )
2015
27
Application of a Pattern-based Classification System for Invasive Endocervical Adenocarcinoma in Cervical Biopsy, Cone and Loop Electrosurgical Excision (LEEP) Material: Pattern on Cone and LEEP is predictive of Pattern in the Overall Tumor. ( 26630232 )
2015
28
Advanced endocervical adenocarcinoma metastatic to the ovary presenting as primary ovarian cancer. ( 25951731 )
2015
29
Gastric-type Endocervical Adenocarcinoma: An Aggressive Tumor With Unusual Metastatic Patterns and Poor Prognosis. ( 26457350 )
2015
30
Invasive Endocervical Adenocarcinoma: A New Pattern-based Classification System With Important Clinical Significance. ( 25724003 )
2015
31
Dysregulation of CDK inhibitors and p53 in HPV-negative endocervical adenocarcinoma. ( 25675191 )
2015
32
Human Papillomavirus-Related Ovarian Metastasis With Endocervical Adenocarcinoma: Report of 2 Cases and Review of Literature. ( 26360235 )
2015
33
A Case of HPV-negative Intestinal-type Endocervical Adenocarcinoma In Situ With Coexisting Multifocal Intestinal and Gastric Metaplasia. ( 24418863 )
2014
34
Direct sampling of metastatic ovarian carcinoma masquerading as endocervical adenocarcinoma in liquid-based cytology cervical sample. ( 25538388 )
2014
35
Interobserver Variability in the Application of a Proposed Histologic Subclassification of Endocervical Adenocarcinoma. ( 25188867 )
2014
36
Magnetic resonance appearance of gastric-type adenocarcinoma of the uterine cervix in comparison with that of usual-type endocervical adenocarcinoma: a pitfall of newly described unusual subtype of endocervical adenocarcinoma. ( 25188888 )
2014
37
Peritoneal metastases from mucinous endocervical adenocarcinoma. ( 26075991 )
2014
38
Numerous psammoma bodies in cervical cytology of high-grade endocervical adenocarcinoma. ( 23855933 )
2014
39
PAX8 and PAX2 expression in endocervical adenocarcinoma in situ and high-grade squamous dysplasia. ( 23202787 )
2013
40
Intestinal-type endocervical adenocarcinoma in situ: an immunophenotypically distinct subset of AIS affecting older women. ( 23552379 )
2013
41
Invasive endocervical adenocarcinoma: proposal for a new pattern-based classification system with significant clinical implications: a multi-institutional study. ( 24071876 )
2013
42
Are women with endocervical adenocarcinoma at risk for lynch syndrome? Evaluation of 101 cases including unusual subtypes and lower uterine segment tumors. ( 22833088 )
2012
43
Diffusion-weighted magnetic resonance imaging to detect synchronous uterine endometrial and endocervical adenocarcinoma. ( 22532917 )
2012
44
Mixed endocervical adenocarcinoma and high-grade neuroendocrine carcinoma of the cervix with ovarian metastasis of the former component: a report of 2 cases. ( 22833092 )
2012
45
Cytological screening of endocervical adenocarcinoma. ( 23244488 )
2012
46
Metastatic endocervical adenocarcinoma in a western lowland gorilla (Gorilla g. gorilla): no evidence of virus-induced carcinogenesis. ( 22273046 )
2012
47
Infection of a lymphocyst after pelvic lymph node dissection for endocervical adenocarcinoma. ( 22779981 )
2012
48
Endocervical adenocarcinoma - Proposal for a new histopathologic pattern-based classification system with significant clinical implications: A multi-institutional study. ( 24989540 )
2012
49
Correlation between invasive pattern and immunophenotypic alterations in endocervical adenocarcinoma. ( 21401700 )
2011
50
PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma. ( 20061933 )
2010

Variations for Endocervical Adenocarcinoma

Expression for Endocervical Adenocarcinoma

Search GEO for disease gene expression data for Endocervical Adenocarcinoma.

Pathways for Endocervical Adenocarcinoma

Pathways related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 CDKN1A CDKN2A PAX8 TP53
2 12.6 CDKN1A CDKN2A PAX8 TP53
3
Show member pathways
12.52 CDKN1A CDKN2A CDX2 TP53
4
Show member pathways
12.18 CDKN1A CDKN2A TP53
5 12.18 CDKN1A CDKN2A TP53 VIM
6 12.17 CDKN1A CDKN2A TP53
7
Show member pathways
12.15 CDKN1A CDKN2A TP53
8 12.14 CDKN1A CDKN2A TP53 VIM
9 12.09 CDKN1A CDKN2A TP53
10 12.05 CDKN1A PAX8 TP53
11 11.94 CDKN1A CDKN2A TP53
12 11.85 CDKN1A CDKN2A TP53
13 11.82 CDX2 PAX2 VIM
14 11.75 CDKN1A CDKN2A TP53
15 11.73 CDKN1A TP53 VIM
16 11.68 CDKN1A CDKN2A TP53
17 11.63 CDKN1A CDKN2A TP53
18 11.49 CDKN1A CDKN2A TP53
19 11.37 CDKN1A PAX2 VIM
20 11.3 CDKN1A CDKN2A TP53
21 11.2 CDKN1A CDKN2A TP53
22 11.13 CDKN1A TP53
23 11.12 CDKN2A TP53
24 10.91 CDKN2A TP53
25 10.84 CDKN1A CDKN2A TP53
26 10.74 PAX2 PAX8
27 10.56 CDKN1A TP53
28
Show member pathways
10.14 CDKN1A CDKN2A TP53

GO Terms for Endocervical Adenocarcinoma

Cellular components related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.26 CDKN1A CDX2 PAX2 TP53
2 intermediate filament GO:0005882 8.8 KRT20 KRT7 VIM

Biological processes related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.92 CDKN2A CDX2 PAX2 PAX8 TP53
2 cell cycle arrest GO:0007050 9.77 CDKN1A CDKN2A TP53
3 negative regulation of cell growth GO:0030308 9.76 CDKN1A CDKN2A TP53
4 Ras protein signal transduction GO:0007265 9.71 CDKN1A CDKN2A TP53
5 cellular response to ionizing radiation GO:0071479 9.65 CDKN1A TP53
6 intrinsic apoptotic signaling pathway GO:0097193 9.64 CDKN1A TP53
7 transcription by RNA polymerase II GO:0006366 9.64 CDX2 PAX2
8 positive regulation of reactive oxygen species metabolic process GO:2000379 9.63 CDKN1A TP53
9 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.63 CDKN1A CDKN2A
10 cellular senescence GO:0090398 9.62 CDKN1A CDKN2A
11 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.62 PAX2 PAX8
12 intermediate filament organization GO:0045109 9.61 KRT20 VIM
13 negative regulation of phosphorylation GO:0042326 9.61 CDKN1A CDKN2A
14 urogenital system development GO:0001655 9.59 PAX2 PAX8
15 mesonephros development GO:0001823 9.58 PAX2 PAX8
16 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.57 PAX2 PAX8
17 pronephros development GO:0048793 9.56 PAX2 PAX8
18 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.55 PAX2 PAX8
19 metanephric epithelium development GO:0072207 9.51 PAX2 PAX8
20 signal transduction by p53 class mediator GO:0072331 9.49 CDKN1A TP53
21 metanephric distal convoluted tubule development GO:0072221 9.48 PAX2 PAX8
22 metanephric nephron tubule formation GO:0072289 9.46 PAX2 PAX8
23 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.43 PAX2 PAX8
24 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.4 PAX2 PAX8
25 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.37 PAX2 PAX8
26 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.32 PAX2 PAX8
27 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.26 PAX2 PAX8
28 positive regulation of metanephric DCT cell differentiation GO:2000594 9.16 PAX2 PAX8
29 pronephric field specification GO:0039003 8.96 PAX2 PAX8
30 replicative senescence GO:0090399 8.8 CDKN1A CDKN2A TP53

Molecular functions related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.62 CDKN1A CDKN2A

Sources for Endocervical Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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