MCID: END075
MIFTS: 39

Endocervical Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Endocervical Adenocarcinoma

MalaCards integrated aliases for Endocervical Adenocarcinoma:

Name: Endocervical Adenocarcinoma 12 15 72
Endocervical Carcinoma 72

Classifications:



External Ids:

Disease Ontology 12 DOID:0050940
UMLS 72 C1263762 C1299237

Summaries for Endocervical Adenocarcinoma

Disease Ontology : 12 An endocervical carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Endocervical Adenocarcinoma, also known as endocervical carcinoma, is related to endometrial adenocarcinoma and adenoid basal cell carcinoma. An important gene associated with Endocervical Adenocarcinoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include cervix, testes and uterus, and related phenotypes are cellular and cardiovascular system

Related Diseases for Endocervical Adenocarcinoma

Diseases related to Endocervical Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 309)
# Related Disease Score Top Affiliating Genes
1 endometrial adenocarcinoma 31.0 TP53 KRT7 CDKN2A
2 adenoid basal cell carcinoma 30.9 KRT7 CDKN2A
3 appendix adenocarcinoma 30.9 KRT7 KRT20 CDX2
4 vulval paget's disease 30.6 KRT7 KRT20 CDKN2A
5 female reproductive endometrioid cancer 30.6 TP53 KRT7
6 cervix uteri carcinoma in situ 30.5 TP53 CDKN2A
7 nephrogenic adenoma 30.5 PAX8 PAX2 KRT7
8 endocervical carcinoma 30.4 PAX8 MUC6 KRT7 CDKN2A
9 teratoma 30.3 TP53 KRT7 CDX2
10 papillary serous adenocarcinoma 30.3 TP53 KRT7 KRT20
11 sweat gland cancer 30.3 TP53 KRT7 KRT20
12 suppressor of tumorigenicity 3 30.3 TP53 CDKN2A CDKN1A
13 basal cell carcinoma 30.2 TP53 KRT7 KRT20
14 rectum adenocarcinoma 30.2 KRT7 KRT20 CDX2
15 small cell carcinoma 30.2 TP53 KRT7 KRT20 CDKN2A
16 adenosquamous carcinoma 30.2 TP53 MUC1 KRT7
17 adenocarcinoma in situ 30.1 PAX8 PAX2 KRT7 KRT20 CDX2 CDKN2A
18 mammary paget's disease 30.0 MUC1 KRT7 KRT20
19 clear cell adenocarcinoma 30.0 PAX8 PAX2 KRT7 KRT20
20 adenomyoma 30.0 MUC6 MUC1 KRT7
21 mucinous adenocarcinoma 29.6 MUC1 KRT7 KRT20 CDX2 CDKN2A
22 papillary adenocarcinoma 29.5 VIM TP53 MUC1 KRT7
23 squamous cell carcinoma 29.2 TP53 MUC1 CDKN2A CDKN1B
24 cervical cancer 29.2 TP53 CDKN2A CDKN1B CDKN1A
25 cervical adenocarcinoma 29.1 TP53 KRT7 KRT20 CDX2 CDKN2A CDKN1A
26 adenoid cystic carcinoma 29.1 VIM TP53 MUC1 KRT7 KRT20
27 cystic teratoma 29.0 TP53 MUC6 KRT7 KRT20 CDX2
28 renal cell carcinoma, nonpapillary 28.7 VIM PAX8 PAX2 MUC1 KRT7 KRT20
29 endometrial cancer 28.7 TP53 PAX8 KRT7 CDKN2A CDKN1B CDKN1A
30 ovarian cancer 28.6 TP53 MUC1 KRT7 CDKN1B CDKN1A
31 papilloma 28.6 TP53 KRT7 KRT20 CDKN2A CDKN1B CDKN1A
32 adenocarcinoma 11.0
33 inverted transitional papilloma 10.7 KRT7 CDKN2A
34 ameloblastic carcinoma 10.7 VIM CDKN2A
35 acral lentiginous melanoma 10.6 VIM CDKN2A
36 benign metastasizing leiomyoma 10.6 VIM KRT7
37 cystic basal cell carcinoma 10.6 KRT7 KRT20
38 malignant syringoma 10.6 KRT7 KRT20
39 transverse colon cancer 10.6 KRT7 KRT20
40 papillary adenoma 10.6 VIM KRT7
41 seminal vesicle adenocarcinoma 10.6 KRT7 KRT20
42 krukenberg carcinoma 10.6 KRT7 KRT20
43 eyelid carcinoma 10.6 KRT7 KRT20
44 papillary transitional carcinoma 10.6 KRT7 KRT20
45 small cell carcinoma of the bladder 10.6 KRT7 KRT20
46 lung acinar adenocarcinoma 10.6 KRT7 KRT20
47 linitis plastica 10.6 KRT7 KRT20
48 large intestine adenocarcinoma 10.6 KRT7 KRT20
49 intratubular embryonal carcinoma 10.6 KRT7 KRT20
50 rete testis adenoma 10.6 PAX8 PAX2

Graphical network of the top 20 diseases related to Endocervical Adenocarcinoma:



Diseases related to Endocervical Adenocarcinoma

Symptoms & Phenotypes for Endocervical Adenocarcinoma

MGI Mouse Phenotypes related to Endocervical Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.11 CDKN1A CDKN1B CDKN2A CDX2 KRT7 PAX2
2 cardiovascular system MP:0005385 10.08 CDKN1A CDKN1B CDKN2A CDX2 PAX2 PAX8
3 embryo MP:0005380 10.03 CDKN1A CDKN1B CDKN2A CDX2 PAX2 PAX8
4 endocrine/exocrine gland MP:0005379 9.95 CDKN1A CDKN1B CDKN2A CDX2 PAX2 PAX8
5 hearing/vestibular/ear MP:0005377 9.77 CDKN1A CDKN1B PAX2 PAX8 TP53
6 neoplasm MP:0002006 9.72 CDKN1A CDKN1B CDKN2A CDX2 TP53
7 renal/urinary system MP:0005367 9.63 CDKN1A CDKN1B KRT7 PAX2 PAX8 TP53
8 pigmentation MP:0001186 9.56 CDKN1B CDKN2A PAX2 TP53
9 reproductive system MP:0005389 9.56 CDKN1A CDKN1B CDKN2A CDX2 PAX2 PAX8
10 vision/eye MP:0005391 9.17 CDKN1A CDKN1B CDKN2A PAX2 PAX8 TP53

Drugs & Therapeutics for Endocervical Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Endocervical Adenocarcinoma

Genetic Tests for Endocervical Adenocarcinoma

Anatomical Context for Endocervical Adenocarcinoma

MalaCards organs/tissues related to Endocervical Adenocarcinoma:

41
Cervix, Testes, Uterus, Lymph Node, Ovary, Heart, Smooth Muscle

Publications for Endocervical Adenocarcinoma

Articles related to Endocervical Adenocarcinoma:

(show top 50) (show all 378)
# Title Authors PMID Year
1
Endocervical adenocarcinoma in situ (AIS) with ovarian and pulmonary involvement: report of a case and review of the literature suggesting a "seed and soil hypothesis". 38
31309301 2019
2
Isolated metastatic pancreatic adenocarcinoma to the uterine cervix: A case report. 38
31334322 2019
3
Robust expression of EZH2 in endocervical neoplastic lesions. 38
30903272 2019
4
Molecular characterization of gastric-type endocervical adenocarcinoma using next-generation sequencing. 38
31308508 2019
5
Gastric-type endocervical adenocarcinoma with uterine corpus involvement mimicking primary endometrial carcinoma. 38
31012190 2019
6
Endocervical Adenocarcinoma In Situ Phenotype with Ovarian Metastasis. 38
30599504 2019
7
The transcriptome profiles and methylation status revealed the potential cancer-related lncRNAs in patients with cervical cancer. 38
30362566 2019
8
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism. 38
31221981 2019
9
Cervical Glandular Neoplasia: Classification and Staging. 38
31097105 2019
10
Recent advances in invasive adenocarcinoma of the cervix. 38
31209635 2019
11
Challenges in the Pap diagnosis of endocervical adenocarcinoma in situ. 38
31097290 2019
12
A case of gastric-type mucinous endocervical adenocarcinoma in presence of nabothian cysts. 38
30878235 2019
13
Clinical significance of the pattern-based classification in endocervical adenocarcinoma, usual and variants. 38
31140099 2019
14
International Endocervical Adenocarcinoma Criteria and Classification (IECC): correlation with adverse clinicopathological features and patient outcome. 38
30679193 2019
15
Dual prognostic role of 2-oxoglutarate-dependent oxygenases in ten cancer types: implications for cell cycle regulation and cell adhesion maintenance. 38
31036064 2019
16
[Focus on mucinous adenocarcinoma of the uterine cervix]. 38
30771514 2019
17
Reconstruction and analysis of circRNA‑miRNA‑mRNA network in the pathology of cervical cancer. 38
30816541 2019
18
HPV DNA integration site as proof of the origin of ovarian metastasis from endocervical adenocarcinoma: three case reports. 38
31014281 2019
19
Immunohistochemical expression of HIK1083 and MUC6 in endometrial carcinomas. 38
31021421 2019
20
Clinical Outcomes of HPV-associated and Unassociated Endocervical Adenocarcinomas Categorized by the International Endocervical Adenocarcinoma Criteria and Classification (IECC). 38
30720532 2019
21
Analysis of gastric-type mucinous carcinoma of the uterine cervix - An aggressive tumor with a poor prognosis: A multi-institutional study. 38
30709650 2019
22
Combined Transcriptome and Proteome Analysis of Immortalized Human Keratinocytes Expressing Human Papillomavirus 16 (HPV16) Oncogenes Reveals Novel Key Factors and Networks in HPV-Induced Carcinogenesis. 38
30918060 2019
23
Study of the revisited, revised, and expanded Silva pattern system for Chinese endocervical adenocarcinoma patients. 38
30218754 2019
24
[Application and clinical significance of Silva pattern system in invasive endocervical adenocarcinoma]. 38
30695900 2019
25
International Endocervical Adenocarcinoma Criteria and Classification: Validation and Interobserver Reproducibility. 38
29877920 2019
26
Epigenetic-Mediated Downregulation of Zinc Finger Protein 671 (ZNF671) Predicts Poor Prognosis in Multiple Solid Tumors. 38
31134149 2019
27
Identification of Cancer Dysfunctional Subpathways by Integrating DNA Methylation, Copy Number Variation, and Gene-Expression Data. 38
31156704 2019
28
Cervical Adenocarcinomas: A Heterogeneous Group of Tumors With Variable Etiologies and Clinical Outcomes. 38
30785336 2019
29
Gastric-type Adenocarcinoma of the Cervix: Tumor With Wide Range of Histologic Appearances. 38
30234500 2019
30
Independent validation of the prognostic significance of invasion patterns in endocervical adenocarcinoma: Pattern A predicts excellent survival. 38
30262404 2018
31
Metastatic Endocervical Adenocarcinoma in a Mature Cystic Teratoma: A Case of a Tumor-to-Tumor Metastasis. 38
29140879 2018
32
The clinicopathologic and immunohistochemical features of villoglandular adenocarcinoma of uterine cervix. 38
30303146 2018
33
Folate Receptor Alpha Expression in Platinum Resistant/Refractory Ovarian Carcinomas and Primary Endocervical Adenocarcinomas. 38
27941566 2018
34
Diagnostic Algorithmic Proposal Based on Comprehensive Immunohistochemical Evaluation of 297 Invasive Endocervical Adenocarcinomas. 38
29851704 2018
35
Interpretation of Endocervical Cells With Gastric-Type Mucin on Pap Smears: A Proposal for a Cytologic Category "Atypical Endocervical Cells With Gastric-Type Mucin". 38
29982289 2018
36
Methods for Measuring and Staging a Uterine Cervical Adenocarcinoma Showing Intracystic Papillary Growth: A Case Report. 38
28700431 2018
37
Gastric-type Endocervical Adenocarcinoma Involving the Endometrium and Clinically Mimicking Endometrial Neoplasia: A Diagnostic Challenge. 38
29683820 2018
38
Gastric-Type Adenocarcinoma of the Uterine Cervix: Magnetic Resonance Imaging Features, Clinical Outcomes, and Prognostic Factors. 38
29683881 2018
39
Stromal p16 Overexpression in Gastric-type Mucinous Carcinoma of the Uterine Cervix. 38
29848709 2018
40
Endovascular management of TransAtlantic Inter-Society Consensus D iliac artery occlusion secondary to radiation arteritis. 38
29942894 2018
41
The pattern is the issue: recent advances in adenocarcinoma of the uterine cervix. 38
29404709 2018
42
Cervical Adenocarcinoma: A Comparison of the Reproducibility of the World Health Organization 2003 and 2014 Classifications. 38
29474242 2018
43
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix. 38
29135516 2018
44
Pattern based classification of endocervical adenocarcinoma: a review. 38
29241973 2018
45
High proportion of abnormal pap smear tests and cervical dysplasia in women with cystic fibrosis. 38
29245055 2018
46
Mechanism of the anti-angiogenic effect of Avemar on tumor cells. 38
29434991 2018
47
Gastric type mucinous endocervical adenocarcinoma of the uterine cervix: very rare and interesting case. 38
29372165 2018
48
Chemoresistance of Gastric-Type Mucinous Carcinoma of the Uterine Cervix: A Study of the Sankai Gynecology Study Group. 38
29206664 2018
49
Colloid Carcinoma of the Uterine Cervix and Its Immunohistochemical Analysis: A Case Report. 38
29370509 2018
50
Genomic abnormalities in invasive endocervical adenocarcinoma correlate with pattern of invasion: biologic and clinical implications. 38
28731050 2017

Variations for Endocervical Adenocarcinoma

Expression for Endocervical Adenocarcinoma

Search GEO for disease gene expression data for Endocervical Adenocarcinoma.

Pathways for Endocervical Adenocarcinoma

Pathways related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.73 TP53 PAX8 CDKN2A CDKN1B CDKN1A
2 12.68 TP53 PAX8 CDKN2A CDKN1B CDKN1A
3
Show member pathways
12.56 TP53 CDKN2A CDKN1B CDKN1A
4
Show member pathways
12.56 TP53 CDX2 CDKN2A CDKN1B CDKN1A
5
Show member pathways
12.45 TP53 CDKN2A CDKN1B CDKN1A
6 12.41 VIM MUC1 KRT7 KRT20
7
Show member pathways
12.25 TP53 CDKN2A CDKN1B CDKN1A
8 12.24 TP53 CDKN2A CDKN1B CDKN1A
9
Show member pathways
12.22 TP53 CDKN2A CDKN1B CDKN1A
10 12.21 VIM TP53 CDKN2A CDKN1B CDKN1A
11 12.14 TP53 CDKN2A CDKN1B CDKN1A
12 12.13 VIM TP53 CDKN2A CDKN1B CDKN1A
13
Show member pathways
12.09 CDKN2A CDKN1B CDKN1A
14 12.05 TP53 PAX8 CDKN1B CDKN1A
15 12.04 TP53 CDKN2A CDKN1A
16 11.95 VIM PAX2 CDX2
17 11.92 TP53 CDKN2A CDKN1A
18 11.9 VIM TP53 CDKN1B
19
Show member pathways
11.82 TP53 CDKN1B CDKN1A
20 11.79 TP53 CDKN2A CDKN1B CDKN1A
21 11.76 TP53 CDKN1B CDKN1A
22 11.76 VIM TP53 MUC1 CDKN1A
23 11.73 TP53 CDKN1B CDKN1A
24 11.71 TP53 CDKN2A CDKN1B CDKN1A
25 11.64 TP53 CDKN2A CDKN1A
26 11.64 TP53 CDKN2A CDKN1A
27 11.58 TP53 CDKN2A CDKN1A
28 11.48 TP53 CDKN2A CDKN1B CDKN1A
30 11.41 TP53 CDKN2A CDKN1A
31 11.39 TP53 CDKN1B CDKN1A
32 11.3 TP53 CDKN1B CDKN1A
33 11 TP53 CDKN2A
34 10.85 PAX8 PAX2
35 10.79 VIM PAX2 CDKN1B CDKN1A
36 10.72 TP53 CDKN1A
37
Show member pathways
10.47 TP53 CDKN2A CDKN1A

GO Terms for Endocervical Adenocarcinoma

Cellular components related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.65 VIM TP53 PAX8 PAX2 MUC1 KRT7
2 protein-containing complex GO:0032991 9.02 TP53 PAX2 CDX2 CDKN1B CDKN1A

Biological processes related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.95 TP53 CDKN2A CDKN1B CDKN1A
2 cytokine-mediated signaling pathway GO:0019221 9.92 VIM TP53 MUC1 CDKN1A
3 G1/S transition of mitotic cell cycle GO:0000082 9.8 CDKN2A CDKN1B CDKN1A
4 cell cycle arrest GO:0007050 9.8 TP53 CDKN2A CDKN1B CDKN1A
5 Ras protein signal transduction GO:0007265 9.77 TP53 CDKN2A CDKN1A
6 cellular senescence GO:0090398 9.65 CDKN2A CDKN1A
7 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.65 PAX8 PAX2
8 intermediate filament organization GO:0045109 9.64 VIM KRT20
9 urogenital system development GO:0001655 9.64 PAX8 PAX2
10 mesonephros development GO:0001823 9.63 PAX8 PAX2
11 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.63 TP53 MUC1
12 negative regulation of cell growth GO:0030308 9.62 TP53 CDKN2A CDKN1B CDKN1A
13 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.61 PAX8 PAX2
14 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.59 PAX8 PAX2
15 pronephros development GO:0048793 9.58 PAX8 PAX2
16 signal transduction by p53 class mediator GO:0072331 9.58 TP53 CDKN1A
17 metanephric epithelium development GO:0072207 9.57 PAX8 PAX2
18 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.56 PAX8 PAX2
19 negative regulation of cyclin-dependent protein kinase activity GO:1904030 9.55 CDKN1B CDKN1A
20 metanephric nephron tubule formation GO:0072289 9.54 PAX8 PAX2
21 metanephric distal convoluted tubule development GO:0072221 9.52 PAX8 PAX2
22 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.51 PAX8 PAX2
23 pronephric field specification GO:0039003 9.48 PAX8 PAX2
24 positive regulation of metanephric DCT cell differentiation GO:2000594 9.46 PAX8 PAX2
25 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.43 PAX8 PAX2
26 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.43 CDKN2A CDKN1B CDKN1A
27 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.4 PAX8 PAX2
28 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.37 PAX8 PAX2
29 negative regulation of phosphorylation GO:0042326 9.33 CDKN2A CDKN1B CDKN1A
30 replicative senescence GO:0090399 9.13 TP53 CDKN2A CDKN1A
31 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 8.92 TP53 MUC1 CDKN1B CDKN1A
32 positive regulation of transcription, DNA-templated GO:0045893 10.01 TP53 PAX8 PAX2 CDX2 CDKN2A

Molecular functions related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.26 TP53 CDKN2A CDKN1B CDKN1A
2 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.8 CDKN2A CDKN1B CDKN1A

Sources for Endocervical Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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