MCID: END075
MIFTS: 36

Endocervical Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Endocervical Adenocarcinoma

MalaCards integrated aliases for Endocervical Adenocarcinoma:

Name: Endocervical Adenocarcinoma 12 15 71
Endocervical Carcinoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050940
UMLS 71 C1263762 C1299237

Summaries for Endocervical Adenocarcinoma

Disease Ontology : 12 An endocervical carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Endocervical Adenocarcinoma, also known as endocervical carcinoma, is related to suppressor of tumorigenicity 3 and appendix adenocarcinoma. An important gene associated with Endocervical Adenocarcinoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. Affiliated tissues include cervix, ovary and colon, and related phenotype is vision/eye.

Related Diseases for Endocervical Adenocarcinoma

Diseases related to Endocervical Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 410)
# Related Disease Score Top Affiliating Genes
1 suppressor of tumorigenicity 3 31.3 TP53 CDKN2A CDKN1A
2 appendix adenocarcinoma 31.0 KRT7 KRT20 CEACAM5 CDX2
3 endometrial adenocarcinoma 31.0 VIM TP53 MUC1 KRT7 CDKN2A
4 serous cystadenocarcinoma 30.9 TP53 PAX8 CDKN1A
5 adenocarcinoma 30.7 TP53 MUC1 KRT7 KRT20 CEACAM5 CDX2
6 cervical adenocarcinoma 30.7 TP53 KRT7 KRT20 CEACAM5 CDX2 CDKN2A
7 female reproductive endometrioid cancer 30.7 TP53 PAX8 KRT7
8 vulval paget's disease 30.7 KRT7 CEACAM5
9 adenocarcinoma in situ 30.6 U2AF1 PAX8 PAX2 KRT7 KRT20 CEACAM5
10 mammary paget's disease 30.6 MUC1 KRT7 KRT20
11 papilloma 30.6 TP53 KRT7 KRT20 CDKN2A CDKN1B CDKN1A
12 adenosquamous carcinoma 30.5 TP53 MUC1 KRT7 CEACAM5
13 nephrogenic adenoma 30.5 PAX8 PAX2 MUC1 KRT7
14 sweat gland cancer 30.4 TP53 KRT7 KRT20 CEACAM5
15 clear cell adenocarcinoma 30.4 TP53 PAX8 PAX2 KRT7 KRT20
16 small cell carcinoma 30.3 TP53 MUC1 KRT7 KRT20 CDX2 CDKN2A
17 neuroendocrine carcinoma 30.3 MUC1 KRT7 KRT20 CEACAM5
18 adenoma 30.2 TP53 MUC6 MUC5AC MUC1 KRT7 CDX2
19 papillary serous adenocarcinoma 30.2 TP53 PAX8 KRT7 KRT20 CEACAM5
20 rectum adenocarcinoma 30.2 TP53 KRT7 KRT20 CEACAM5 CDX2
21 adenoid cystic carcinoma 30.1 VIM TP53 MUC1 KRT7 KRT20 CDKN2A
22 teratoma 30.1 VIM TP53 KRT7 KRT20 CEACAM5 CDX2
23 basal cell carcinoma 30.0 TP53 KRT7 KRT20 CEACAM5 CDKN2A CDKN1A
24 mucinous adenocarcinoma 30.0 VIM TP53 MUC5AC MUC1 KRT7 KRT20
25 papillary adenocarcinoma 29.9 VIM TP53 MUC1 KRT7 CEACAM5 CEACAM3
26 endometrial cancer 29.8 TP53 PAX8 MUC1 KRT7 KRT20 CEACAM5
27 renal cell carcinoma, nonpapillary 29.6 VIM TP53 PAX8 PAX2 MUC1 KRT7
28 cystic teratoma 29.5 TP53 MUC6 MUC5AC KRT7 KRT20 CEACAM5
29 ovary adenocarcinoma 29.5 TP53 PAX8 MUC1 KRT7 KRT20 CEACAM5
30 squamous cell carcinoma 29.4 U2AF1 TP53 MUC1 CEACAM5 CDKN2A CDKN1B
31 thyroid gland cancer 29.1 U2AF1 TP53 PAX8 KRT7 KRT20 CEACAM5
32 ovarian cancer 28.7 VIM TP53 PAX8 MUC5AC MUC1 KRT7
33 endocervical carcinoma 28.2 ZNF441 VIM U2AF1 TP53 PAX8 MUC6
34 cervical basaloid squamous cell carcinoma 10.7 KRT7 CDKN2A
35 inverted transitional papilloma 10.6 KRT7 CDKN2A
36 endometrial transitional cell carcinoma 10.6 KRT7 CDKN2A
37 anus basaloid carcinoma 10.6 KRT7 CDKN2A
38 pancreatic serous cystadenocarcinoma 10.6 KRT7 KRT20
39 intrahepatic bile duct adenoma 10.6 KRT7 KRT20
40 cervical adenoid cystic carcinoma 10.6 KRT7 CDKN2A
41 vulvar intraepithelial neoplasia 10.6 TP53 CDKN2A
42 bladder signet ring cell adenocarcinoma 10.6 KRT7 CDX2
43 ovary neuroendocrine neoplasm 10.6 KRT7 CDX2
44 scrotum paget's disease 10.6 MUC1 KRT7
45 ovarian mesodermal adenosarcoma 10.6 PAX8 KRT7
46 ovarian large-cell neuroendocrine carcinoma 10.6 KRT7 KRT20
47 urethra adenocarcinoma 10.6 PAX8 PAX2
48 small cell carcinoma of the bladder 10.6 KRT7 KRT20
49 urinary bladder small cell neuroendocrine carcinoma 10.6 KRT7 KRT20
50 rete testis adenoma 10.6 PAX8 PAX2

Graphical network of the top 20 diseases related to Endocervical Adenocarcinoma:



Diseases related to Endocervical Adenocarcinoma

Symptoms & Phenotypes for Endocervical Adenocarcinoma

MGI Mouse Phenotypes related to Endocervical Adenocarcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.28 CDK2AP2 CDKN1A CDKN1B CDKN2A MUC5AC PAX2

Drugs & Therapeutics for Endocervical Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Endocervical Adenocarcinoma

Genetic Tests for Endocervical Adenocarcinoma

Anatomical Context for Endocervical Adenocarcinoma

MalaCards organs/tissues related to Endocervical Adenocarcinoma:

40
Cervix, Ovary, Colon, Testes, Thyroid, Liver, Kidney

Publications for Endocervical Adenocarcinoma

Articles related to Endocervical Adenocarcinoma:

(show top 50) (show all 394)
# Title Authors PMID Year
1
Cervical Adenocarcinoma: Histopathologic Features From Biopsies to Predict Tumor Behavior. 61
31567190 2020
2
Cervical adenocarcinoma: integration of HPV status, pattern of invasion, morphology and molecular markers into classification. 61
31846527 2020
3
[Clinicopathological features of stratified mucin-producing neoplastic lesions of the cervix]. 61
31914531 2020
4
Immunophenotype analysis using CLDN18, CDH17, and PAX8 for the subcategorization of endocervical adenocarcinomas in situ: gastric-type, intestinal-type, gastrointestinal-type, and Müllerian-type. 61
31932920 2020
5
Gastric-type mucinous carcinoma of the cervix and its precursors - historical overview. 61
31846534 2020
6
Molecular characterization of gastric-type endocervical adenocarcinoma using next-generation sequencing. 61
31308508 2019
7
Identification of hub genes and key pathways associated with the progression of gynecological cancer. 61
31788113 2019
8
A systematic analysis of immune genes and overall survival in cancer patients. 61
31842801 2019
9
Genomic Characterization of HPV-related and Gastric-type Endocervical Adenocarcinoma: Correlation With Subtype and Clinical Behavior. 61
31855952 2019
10
A novel group of HPV-related adenocarcinomas of the lower anogenital tract (vagina, vulva, and anorectum) in women and men resembling HPV-related endocervical adenocarcinomas. 61
31857682 2019
11
Recent advances in invasive adenocarcinoma of the cervix. 61
31209635 2019
12
Hysteroscopic detection of endocervical adenocarcinoma. 61
31759553 2019
13
Clinical significance of the pattern-based classification in endocervical adenocarcinoma, usual and variants. 61
31140099 2019
14
Immunohistochemical expression of HIK1083 and MUC6 in endometrial carcinomas. 61
31021421 2019
15
Advancing Pan-cancer Gene Expression Survial Analysis by Inclusion of Non-coding RNA. 61
31607216 2019
16
Synchronous quadruple primary malignancies of the cervix, endometrium, ovary, and stomach in a single patient: A case report and review of literature. 61
31667193 2019
17
Expanded study on the risk of lymphovascular space invasion and lymph node metastasis of endocervical adenocarcinoma using Pattern Classification: a single-centre analysis of 213 cases. 61
31445810 2019
18
Clinicopathologic Association and Prognostic Value of MELF Pattern in Invasive Endocervical Adenocarcinoma (ECA) as Classified by IECC. 61
31517653 2019
19
Endocervical adenocarcinoma in situ (AIS) with ovarian and pulmonary involvement: report of a case and review of the literature suggesting a "seed and soil hypothesis". 61
31309301 2019
20
Isolated metastatic pancreatic adenocarcinoma to the uterine cervix: A case report. 61
31334322 2019
21
Robust expression of EZH2 in endocervical neoplastic lesions. 61
30903272 2019
22
Gastric-type endocervical adenocarcinoma with uterine corpus involvement mimicking primary endometrial carcinoma. 61
31012190 2019
23
Endocervical Adenocarcinoma In Situ Phenotype with Ovarian Metastasis. 61
30599504 2019
24
The transcriptome profiles and methylation status revealed the potential cancer-related lncRNAs in patients with cervical cancer. 61
30362566 2019
25
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism. 61
31221981 2019
26
Cervical Glandular Neoplasia: Classification and Staging. 61
31097105 2019
27
Challenges in the Pap diagnosis of endocervical adenocarcinoma in situ. 61
31097290 2019
28
International Endocervical Adenocarcinoma Criteria and Classification (IECC): correlation with adverse clinicopathological features and patient outcome. 61
30679193 2019
29
A case of gastric-type mucinous endocervical adenocarcinoma in presence of nabothian cysts. 61
30878235 2019
30
Dual prognostic role of 2-oxoglutarate-dependent oxygenases in ten cancer types: implications for cell cycle regulation and cell adhesion maintenance. 61
31036064 2019
31
[Focus on mucinous adenocarcinoma of the uterine cervix]. 61
30771514 2019
32
Reconstruction and analysis of circRNA‑miRNA‑mRNA network in the pathology of cervical cancer. 61
30816541 2019
33
HPV DNA integration site as proof of the origin of ovarian metastasis from endocervical adenocarcinoma: three case reports. 61
31014281 2019
34
Clinical Outcomes of HPV-associated and Unassociated Endocervical Adenocarcinomas Categorized by the International Endocervical Adenocarcinoma Criteria and Classification (IECC). 61
30720532 2019
35
Analysis of gastric-type mucinous carcinoma of the uterine cervix - An aggressive tumor with a poor prognosis: A multi-institutional study. 61
30709650 2019
36
Combined Transcriptome and Proteome Analysis of Immortalized Human Keratinocytes Expressing Human Papillomavirus 16 (HPV16) Oncogenes Reveals Novel Key Factors and Networks in HPV-Induced Carcinogenesis. 61
30918060 2019
37
Study of the revisited, revised, and expanded Silva pattern system for Chinese endocervical adenocarcinoma patients. 61
30218754 2019
38
[Application and clinical significance of Silva pattern system in invasive endocervical adenocarcinoma]. 61
30695900 2019
39
International Endocervical Adenocarcinoma Criteria and Classification: Validation and Interobserver Reproducibility. 61
29877920 2019
40
Epigenetic-Mediated Downregulation of Zinc Finger Protein 671 (ZNF671) Predicts Poor Prognosis in Multiple Solid Tumors. 61
31134149 2019
41
Identification of Cancer Dysfunctional Subpathways by Integrating DNA Methylation, Copy Number Variation, and Gene-Expression Data. 61
31156704 2019
42
Gastric-type Adenocarcinoma of the Cervix: Tumor With Wide Range of Histologic Appearances. 61
30234500 2019
43
Cervical Adenocarcinomas: A Heterogeneous Group of Tumors With Variable Etiologies and Clinical Outcomes. 61
30785336 2019
44
High-risk HPV E6/E7 mRNA in situ hybridization in endocervical glandular neoplasia: performance compared with p16INK4a and Ki67 immunochemistry. 61
31737201 2019
45
Independent validation of the prognostic significance of invasion patterns in endocervical adenocarcinoma: Pattern A predicts excellent survival. 61
30262404 2018
46
Metastatic Endocervical Adenocarcinoma in a Mature Cystic Teratoma: A Case of a Tumor-to-Tumor Metastasis. 61
29140879 2018
47
The clinicopathologic and immunohistochemical features of villoglandular adenocarcinoma of uterine cervix. 61
30303146 2018
48
Folate Receptor Alpha Expression in Platinum Resistant/Refractory Ovarian Carcinomas and Primary Endocervical Adenocarcinomas. 61
27941566 2018
49
Diagnostic Algorithmic Proposal Based on Comprehensive Immunohistochemical Evaluation of 297 Invasive Endocervical Adenocarcinomas. 61
29851704 2018
50
Methods for Measuring and Staging a Uterine Cervical Adenocarcinoma Showing Intracystic Papillary Growth: A Case Report. 61
28700431 2018

Variations for Endocervical Adenocarcinoma

Expression for Endocervical Adenocarcinoma

Search GEO for disease gene expression data for Endocervical Adenocarcinoma.

Pathways for Endocervical Adenocarcinoma

Pathways related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1 12.74 TP53 PAX8 CDKN2A CDKN1B CDKN1A
2
Show member pathways
12.62 TP53 CDX2 CDKN2A CDKN1B CDKN1A
3 12.32 VIM TP53 CDKN2A CDKN1B CDKN1A
4
Show member pathways
12.27 TP53 CDKN2A CDKN1B CDKN1A
5 12.27 VIM TP53 CDKN2A CDKN1B CDKN1A
6 12.25 TP53 CDKN2A CDKN1B CDKN1A
7
Show member pathways
12.22 TP53 CDKN2A CDKN1B CDKN1A
8 12.14 TP53 CDKN2A CDKN1B CDKN1A
9 12.09 TP53 PAX8 CDKN1B CDKN1A
10 11.73 TP53 CDKN1B CDKN1A
11 11.73 TP53 CDKN2A CDKN1B CDKN1A
12 11.68 VIM TP53 MUC1 CDKN1A
13 11.62 TP53 CDKN2A CDKN1A
14 11.62 TP53 CDKN2A CDKN1A
15 11.6 TP53 CDKN2A CDKN1B CDKN1A
16 11.48 TP53 CDKN2A CDKN1B CDKN1A
18 11.38 TP53 CDKN2A CDKN1A
19 11.35 TP53 CDKN1B CDKN1A
20 11.3 TP53 CDKN1B CDKN1A
21 10.79 VIM PAX2 CDKN1B CDKN1A
22 10.68 TP53 CDKN1A
23
Show member pathways
10.47 TP53 CDKN2A CDKN1A
24
Show member pathways
10.45 TP53 CDKN1A

GO Terms for Endocervical Adenocarcinoma

Biological processes related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 cell cycle arrest GO:0007050 9.85 TP53 CDKN2A CDKN1B CDKN1A
2 negative regulation of cell growth GO:0030308 9.83 TP53 CDKN2A CDKN1B CDKN1A
3 Ras protein signal transduction GO:0007265 9.81 TP53 CDKN2A CDKN1A
4 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.81 CDKN2A CDKN1A CDK2AP2
5 O-glycan processing GO:0016266 9.8 MUC6 MUC5AC MUC1
6 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.69 CDKN2A CDKN1B CDKN1A
7 mesonephros development GO:0001823 9.64 PAX8 PAX2
8 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 9.62 TP53 MUC1
9 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.62 PAX8 PAX2
10 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.61 PAX8 PAX2
11 pronephros development GO:0048793 9.61 PAX8 PAX2
12 signal transduction by p53 class mediator GO:0072331 9.6 TP53 CDKN1A
13 metanephric epithelium development GO:0072207 9.59 PAX8 PAX2
14 negative regulation of cyclin-dependent protein kinase activity GO:1904030 9.58 CDKN1B CDKN1A
15 metanephric nephron tubule formation GO:0072289 9.58 PAX8 PAX2
16 metanephric distal convoluted tubule development GO:0072221 9.57 PAX8 PAX2
17 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.56 PAX8 PAX2
18 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.54 PAX8 PAX2
19 mitotic cell cycle arrest GO:0071850 9.5 TP53 CDKN1B CDKN1A
20 positive regulation of metanephric DCT cell differentiation GO:2000594 9.49 PAX8 PAX2
21 negative regulation of cardiac muscle tissue regeneration GO:1905179 9.48 CDKN1B CDKN1A
22 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.46 PAX8 PAX2
23 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.43 PAX8 PAX2
24 negative regulation of phosphorylation GO:0042326 9.43 CDKN2A CDKN1B CDKN1A
25 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.4 PAX8 PAX2
26 pronephric field specification GO:0039003 9.37 PAX8 PAX2
27 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.33 TP53 MUC1 CDKN1A
28 replicative senescence GO:0090399 9.13 TP53 CDKN2A CDKN1A
29 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 8.92 TP53 MUC1 CDKN1B CDKN1A

Molecular functions related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.8 CDKN2A CDKN1B CDKN1A

Sources for Endocervical Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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