MCID: END075
MIFTS: 37

Endocervical Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Endocervical Adenocarcinoma

MalaCards integrated aliases for Endocervical Adenocarcinoma:

Name: Endocervical Adenocarcinoma 12 15 71
Endocervical Carcinoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050940
UMLS 71 C1263762 C1299237

Summaries for Endocervical Adenocarcinoma

Disease Ontology : 12 An endocervical carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Endocervical Adenocarcinoma, also known as endocervical carcinoma, is related to suppressor of tumorigenicity 3 and appendix adenocarcinoma. An important gene associated with Endocervical Adenocarcinoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Pathways in cancer and Glioma. Affiliated tissues include cervix, testes and uterus, and related phenotypes are embryo and vision/eye

Related Diseases for Endocervical Adenocarcinoma

Diseases related to Endocervical Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 442)
# Related Disease Score Top Affiliating Genes
1 suppressor of tumorigenicity 3 31.3 TP53 CDKN2A CDKN1A
2 appendix adenocarcinoma 31.2 KRT7 KRT20 CEACAM5 CDX2
3 squamous cell papilloma 31.0 TP53 CDKN2A
4 adenocarcinoma in situ 31.0 U2AF1 PAX8 PAX2 KRT7 KRT20 CEACAM5
5 adenocarcinoma 30.9 U2AF1 TP53 MUC1 KRT7 KRT20 CEACAM5
6 endometrial adenocarcinoma 30.8 VIM TP53 MUC1 KRT7 ESR1 CDKN2A
7 vulval paget's disease 30.7 KRT7 CEACAM5
8 adenosquamous carcinoma 30.7 TP53 MUC1 KRT7 CEACAM5
9 serous cystadenocarcinoma 30.7 TP53 PAX8 KRT7 CDKN2A CDKN1A
10 nephrogenic adenoma 30.7 PAX8 PAX2 MUC1 KRT7
11 adenoid basal cell carcinoma 30.6 KRT7 CEACAM5
12 female reproductive endometrioid cancer 30.6 TP53 PAX8 ESR1
13 cervical adenocarcinoma 30.6 TP53 KRT7 KRT20 ESR1 CEACAM5 CDX2
14 papilloma 30.6 TP53 KRT7 KRT20 ESR1 CDKN2A CDKN1B
15 clear cell adenocarcinoma 30.5 TP53 PAX8 PAX2 KRT7 KRT20
16 small cell carcinoma 30.5 TP53 MUC1 KRT7 KRT20 CDX2 CDKN2A
17 adenomyoma 30.5 MUC1 KRT7 ESR1 CDKN2A
18 neuroendocrine carcinoma 30.5 MUC1 KRT7 KRT20 CEACAM5
19 mammary paget's disease 30.5 MUC1 KRT7 KRT20 ESR1
20 papillary serous adenocarcinoma 30.4 TP53 PAX8 KRT7 KRT20 CEACAM5
21 adenoid cystic carcinoma 30.3 VIM TP53 MUC1 KRT7 KRT20 CDKN2A
22 adenoma 30.3 TP53 MUC6 MUC5AC MUC1 KRT7 KRT20
23 sweat gland cancer 30.2 TP53 KRT7 KRT20 ESR1 CEACAM5
24 papillary adenocarcinoma 30.2 VIM TP53 MUC1 KRT7 CEACAM5 CDX2
25 basal cell carcinoma 30.2 TP53 KRT7 KRT20 CEACAM5 CDKN2A CDKN1A
26 rectum adenocarcinoma 30.1 TP53 SLC25A16 KRT7 KRT20 CEACAM5 CDX2
27 teratoma 30.0 VIM TP53 KRT7 KRT20 ESR1 CEACAM5
28 mucinous adenocarcinoma 30.0 VIM TP53 MUC5AC MUC1 KRT7 KRT20
29 thyroid gland cancer 29.9 TP53 PAX8 KRT7 KRT20 CEACAM5 CDKN1B
30 renal cell carcinoma, nonpapillary 29.9 VIM TP53 PAX8 PAX2 MUC1 KRT7
31 squamous cell carcinoma 29.9 U2AF1 TP53 MUC1 KRT7 CEACAM5 CDKN2A
32 cystic teratoma 29.8 TP53 MUC6 MUC5AC KRT7 KRT20 CEACAM5
33 endometrial cancer 29.7 TP53 PAX8 MUC1 KRT7 KRT20 ESR1
34 ovarian cancer 29.4 VIM TP53 PAX8 MUC5AC MUC1 KRT7
35 endocervical carcinoma 29.1 VIM U2AF1 TP53 SLC25A16 PAX8 MUC6
36 ovary adenocarcinoma 28.9 TP53 SLC25A16 PAX8 MUC6 MUC5AC MUC1
37 cervical basaloid squamous cell carcinoma 10.7 KRT7 CDKN2A
38 inverted transitional papilloma 10.7 KRT7 CDKN2A
39 cervical adenoid cystic carcinoma 10.6 KRT7 CDKN2A
40 prostate squamous cell carcinoma 10.6 TP53 CDKN2A
41 ovary neuroendocrine neoplasm 10.6 KRT7 CDX2
42 rete testis adenoma 10.6 PAX8 PAX2
43 scrotum paget's disease 10.6 MUC1 KRT7
44 cervix endometriosis 10.6 PAX2 CDKN2A
45 vulvar intraepithelial neoplasia 10.6 TP53 CDKN2A
46 endometrial squamous cell carcinoma 10.6 TP53 CDKN2A
47 intrahepatic bile duct adenoma 10.6 KRT7 KRT20
48 malignant peritoneal mesothelioma 10.6 MUC1 CDKN2A
49 rete testis neoplasm 10.6 PAX8 KRT7
50 cervical mucinous adenocarcinoma 10.6 MUC6 KRT7

Graphical network of the top 20 diseases related to Endocervical Adenocarcinoma:



Diseases related to Endocervical Adenocarcinoma

Symptoms & Phenotypes for Endocervical Adenocarcinoma

MGI Mouse Phenotypes related to Endocervical Adenocarcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.61 CDKN1A CDKN1B CDKN2A CDX2 ESR1 PAX2
2 vision/eye MP:0005391 9.28 CDK2AP2 CDKN1A CDKN1B CDKN2A MUC5AC PAX2

Drugs & Therapeutics for Endocervical Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Endocervical Adenocarcinoma

Genetic Tests for Endocervical Adenocarcinoma

Anatomical Context for Endocervical Adenocarcinoma

MalaCards organs/tissues related to Endocervical Adenocarcinoma:

40
Cervix, Testes, Uterus, Lymph Node, Ovary, Heart, Smooth Muscle

Publications for Endocervical Adenocarcinoma

Articles related to Endocervical Adenocarcinoma:

(show top 50) (show all 409)
# Title Authors PMID Year
1
Update on the ISGyP Endocervical Adenocarcinoma Project. 61
32511214 2020
2
NCCN Guidelines Insights: Cervical Cancer, Version 1.2020. 61
32502976 2020
3
Expert consensus from the Italian Society for Colposcopy and Cervico-Vaginal Pathology (SICPCV) for colposcopy and outpatient surgery of the lower genital tract during the COVID-19 pandemic. 61
32270477 2020
4
Transcriptome profiling of gastric-type endocervical adenocarcinomas identifies key signaling pathways for tumor progression. 61
32317172 2020
5
A novel group of HPV-related adenocarcinomas of the lower anogenital tract (vagina, vulva, and anorectum) in women and men resembling HPV-related endocervical adenocarcinomas. 61
31857682 2020
6
A case of non-HPV related primary endometrioid adenocarcinoma of the cervix. 61
32405523 2020
7
The Evolving Spectrum of Precursor Lesions of Cervical Adenocarcinomas. 61
32482967 2020
8
A sporadic gastric-type endocervical adenocarcinoma with endometrial involvement and bilateral ovarian metastasis, a case report. 61
32346591 2020
9
Pan‑cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS‑CoV‑2 infection leading to COVID-19. 61
32468052 2020
10
DGUOK-AS1 promotes cell proliferation in cervical cancer via acting as a ceRNA of miR-653-5p. 61
32283566 2020
11
The evolving spectrum of endocervical adenocarcinoma in situ (AIS). 61
32040619 2020
12
The newly proposed International Endocervical Adenocarcinoma Criteria and Classification and its relevance to cervical cytology screening assessed in a prospective 2-year study of 118 cases. 61
32289186 2020
13
Immunophenotype analysis using CLDN18, CDH17, and PAX8 for the subcategorization of endocervical adenocarcinomas in situ: gastric-type, intestinal-type, gastrointestinal-type, and Müllerian-type. 61
31932920 2020
14
Invasive Stratified Mucinous Carcinoma (iSMC) of the Cervix Often Presents With High-risk Features That Are Determinants of Poor Outcome: An International Multicenter Study. 61
32271191 2020
15
Cervical Adenocarcinoma: Histopathologic Features From Biopsies to Predict Tumor Behavior. 61
31567190 2020
16
[Clinicopathological features of stratified mucin-producing neoplastic lesions of the cervix]. 61
31914531 2020
17
Gastric-type mucinous carcinoma of the cervix and its precursors - historical overview. 61
31846534 2020
18
The New Biomarker for Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (CESC) Based on Public Database Mining. 61
32351997 2020
19
Decreased Expression of NUSAP1 Predicts Poor Overall Survival in Cervical Cancer. 61
32226503 2020
20
Comprehensive analysis of prognostic alternative splicing signature in cervical cancer. 61
32528230 2020
21
Cervical adenocarcinoma: integration of HPV status, pattern of invasion, morphology and molecular markers into classification. 61
31846527 2020
22
Molecular characterization of gastric-type endocervical adenocarcinoma using next-generation sequencing. 61
31308508 2019
23
Identification of hub genes and key pathways associated with the progression of gynecological cancer. 61
31788113 2019
24
A systematic analysis of immune genes and overall survival in cancer patients. 61
31842801 2019
25
Genomic Characterization of HPV-related and Gastric-type Endocervical Adenocarcinoma: Correlation With Subtype and Clinical Behavior. 61
31855952 2019
26
Hysteroscopic detection of endocervical adenocarcinoma. 61
31759553 2019
27
Recent advances in invasive adenocarcinoma of the cervix. 61
31209635 2019
28
Immunohistochemical expression of HIK1083 and MUC6 in endometrial carcinomas. 61
31021421 2019
29
Synchronous quadruple primary malignancies of the cervix, endometrium, ovary, and stomach in a single patient: A case report and review of literature. 61
31667193 2019
30
Advancing Pan-cancer Gene Expression Survial Analysis by Inclusion of Non-coding RNA. 61
31607216 2019
31
Clinical significance of the pattern-based classification in endocervical adenocarcinoma, usual and variants. 61
31140099 2019
32
Expanded study on the risk of lymphovascular space invasion and lymph node metastasis of endocervical adenocarcinoma using Pattern Classification: a single-centre analysis of 213 cases. 61
31445810 2019
33
Clinicopathologic Association and Prognostic Value of MELF Pattern in Invasive Endocervical Adenocarcinoma (ECA) as Classified by IECC. 61
31517653 2019
34
Endocervical adenocarcinoma in situ (AIS) with ovarian and pulmonary involvement: report of a case and review of the literature suggesting a "seed and soil hypothesis". 61
31309301 2019
35
Isolated metastatic pancreatic adenocarcinoma to the uterine cervix: A case report. 61
31334322 2019
36
Gastric-type endocervical adenocarcinoma with uterine corpus involvement mimicking primary endometrial carcinoma. 61
31012190 2019
37
Endocervical Adenocarcinoma In Situ Phenotype with Ovarian Metastasis. 61
30599504 2019
38
Robust expression of EZH2 in endocervical neoplastic lesions. 61
30903272 2019
39
The transcriptome profiles and methylation status revealed the potential cancer-related lncRNAs in patients with cervical cancer. 61
30362566 2019
40
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism. 61
31221981 2019
41
Cervical Glandular Neoplasia: Classification and Staging. 61
31097105 2019
42
International Endocervical Adenocarcinoma Criteria and Classification (IECC): correlation with adverse clinicopathological features and patient outcome. 61
30679193 2019
43
A case of gastric-type mucinous endocervical adenocarcinoma in presence of nabothian cysts. 61
30878235 2019
44
Challenges in the Pap diagnosis of endocervical adenocarcinoma in situ. 61
31097290 2019
45
Dual prognostic role of 2-oxoglutarate-dependent oxygenases in ten cancer types: implications for cell cycle regulation and cell adhesion maintenance. 61
31036064 2019
46
[Focus on mucinous adenocarcinoma of the uterine cervix]. 61
30771514 2019
47
Reconstruction and analysis of circRNA‑miRNA‑mRNA network in the pathology of cervical cancer. 61
30816541 2019
48
HPV DNA integration site as proof of the origin of ovarian metastasis from endocervical adenocarcinoma: three case reports. 61
31014281 2019
49
Clinical Outcomes of HPV-associated and Unassociated Endocervical Adenocarcinomas Categorized by the International Endocervical Adenocarcinoma Criteria and Classification (IECC). 61
30720532 2019
50
Analysis of gastric-type mucinous carcinoma of the uterine cervix - An aggressive tumor with a poor prognosis: A multi-institutional study. 61
30709650 2019

Variations for Endocervical Adenocarcinoma

Expression for Endocervical Adenocarcinoma

Search GEO for disease gene expression data for Endocervical Adenocarcinoma.

Pathways for Endocervical Adenocarcinoma

Pathways related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1 12.64 TP53 PAX8 ESR1 CDKN2A CDKN1B CDKN1A
2
Show member pathways
12.56 TP53 ESR1 CDKN2A CDKN1B CDKN1A
3 12.37 VIM TP53 CDKN2A CDKN1B CDKN1A
4 12.33 VIM TP53 CDKN2A CDKN1B CDKN1A
5
Show member pathways
12.3 TP53 ESR1 CDX2 CDKN2A CDKN1B CDKN1A
6
Show member pathways
12.29 TP53 CDKN2A CDKN1B CDKN1A
7 12.28 TP53 CDKN2A CDKN1B CDKN1A
8
Show member pathways
12.25 TP53 CDKN2A CDKN1B CDKN1A
9 12.19 TP53 CDKN2A CDKN1B CDKN1A
10 12.16 TP53 PAX8 CDKN1B CDKN1A
11
Show member pathways
12.09 ESR1 CDKN2A CDKN1B CDKN1A
12 11.77 TP53 CDKN2A CDKN1B CDKN1A
13 11.75 TP53 CDKN1B CDKN1A
14 11.73 VIM TP53 MUC1 CDKN1A
15 11.67 TP53 CDKN2A CDKN1B CDKN1A
16 11.65 TP53 CDKN2A CDKN1A
17 11.64 TP53 CDKN2A CDKN1A
18 11.58 TP53 CDKN2A CDKN1B CDKN1A
20 11.42 TP53 CDKN2A CDKN1A
21 11.4 TP53 CDKN1B CDKN1A
22 11.37 ESR1 CDKN1B CDKN1A
23 11.33 TP53 CDKN1B CDKN1A
24 10.79 VIM PAX2 CDKN1B CDKN1A
25 10.71 TP53 CDKN1A
26
Show member pathways
10.49 TP53 CDKN1A
27
Show member pathways
10.47 TP53 CDKN2A CDKN1A

GO Terms for Endocervical Adenocarcinoma

Cellular components related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.1 TP53 PAX2 ESR1 CDX2 CDKN1B CDKN1A

Biological processes related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 10.07 TP53 PAX8 PAX2 ESR1 CDX2 CDKN2A
2 cell cycle arrest GO:0007050 9.85 TP53 CDKN2A CDKN1B CDKN1A
3 negative regulation of cell growth GO:0030308 9.83 TP53 CDKN2A CDKN1B CDKN1A
4 Ras protein signal transduction GO:0007265 9.82 TP53 CDKN2A CDKN1A
5 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.81 CDKN2A CDKN1A CDK2AP2
6 O-glycan processing GO:0016266 9.8 MUC6 MUC5AC MUC1
7 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.69 CDKN2A CDKN1B CDKN1A
8 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.65 TP53 ESR1
9 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.65 TP53 ESR1
10 regulation of cell cycle G1/S phase transition GO:1902806 9.64 CDKN1B CDKN1A
11 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 9.63 TP53 MUC1
12 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.63 PAX8 PAX2
13 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.62 PAX8 PAX2
14 pronephros development GO:0048793 9.61 PAX8 PAX2
15 signal transduction by p53 class mediator GO:0072331 9.61 TP53 CDKN1A
16 metanephric epithelium development GO:0072207 9.6 PAX8 PAX2
17 negative regulation of cyclin-dependent protein kinase activity GO:1904030 9.58 CDKN1B CDKN1A
18 metanephric nephron tubule formation GO:0072289 9.58 PAX8 PAX2
19 metanephric distal convoluted tubule development GO:0072221 9.57 PAX8 PAX2
20 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.56 PAX8 PAX2
21 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.54 PAX8 PAX2
22 mitotic cell cycle arrest GO:0071850 9.5 TP53 CDKN1B CDKN1A
23 positive regulation of metanephric DCT cell differentiation GO:2000594 9.49 PAX8 PAX2
24 negative regulation of cardiac muscle tissue regeneration GO:1905179 9.48 CDKN1B CDKN1A
25 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.46 PAX8 PAX2
26 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.43 PAX8 PAX2
27 negative regulation of phosphorylation GO:0042326 9.43 CDKN2A CDKN1B CDKN1A
28 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.4 PAX8 PAX2
29 pronephric field specification GO:0039003 9.37 PAX8 PAX2
30 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.33 TP53 MUC1 CDKN1A
31 replicative senescence GO:0090399 9.13 TP53 CDKN2A CDKN1A
32 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 8.92 TP53 MUC1 CDKN1B CDKN1A

Molecular functions related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.35 TP53 ESR1 CDKN2A CDKN1B CDKN1A
2 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.8 CDKN2A CDKN1B CDKN1A

Sources for Endocervical Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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