Endocervical Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Endocervical Adenocarcinoma

MalaCards integrated aliases for Endocervical Adenocarcinoma:

Name: Endocervical Adenocarcinoma ¹¹ ¹⁴ ⁷¹

Endocervical Carcinoma ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0050940

UMLS ⁷¹ C1263762 C1299237

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Summaries for Endocervical Adenocarcinoma

Disease Ontology: ¹¹ An endocervical carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary: Endocervical Adenocarcinoma, also known as endocervical carcinoma, is related to adenocarcinoma and cervical adenocarcinoma. An important gene associated with Endocervical Adenocarcinoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Toll-like receptor signaling pathway and Endometrial cancer. The drugs Fludarabine and Aldesleukin have been mentioned in the context of this disorder. Affiliated tissues include t cells, cervix and lymph node, and related phenotypes are Decreased viability in pancreas lineage and Increased sensitivity to paclitaxel

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Related Diseases for Endocervical Adenocarcinoma

Diseases related to Endocervical Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 297)

#	Related Disease	Score	Top Affiliating Genes
1	adenocarcinoma	32.0	TP53 SMAD4 PTEN PIK3CA CDKN2A
2	cervical adenocarcinoma	31.6	TP53 MAPK8IP1 CDKN2A
3	adenocarcinoma in situ	31.5	U2AF1 TP53 MUC6 MAPK8IP1 CDKN2A
4	appendix adenocarcinoma	31.1	TP53 SMAD4
5	suppressor of tumorigenicity 3	31.1	TP53 CDKN2A
6	endometrial adenocarcinoma	30.9	TP53 PTEN PAX8 CDKN2A
7	mucinous adenocarcinoma	30.7	U2AF1 TP53 SMAD4 PIK3CA PAX8 MUC6
8	endometrioid ovary carcinoma	30.7	TP53 PTEN PIK3CA ARID1A
9	adenoma	30.6	TP53 SMAD4 PIK3CA MUC6 CDKN2A
10	squamous cell carcinoma	30.6	TP53 SMAD4 PTEN PIK3CA KMT2D FBXW7
11	ovarian mucinous neoplasm	30.6	U2AF1 PAX8 MUC6
12	peutz-jeghers syndrome	30.6	TP53 SMAD4 PTEN MUC6
13	cervical cancer	30.6	U2AF1 TP53 SMAD4 PTEN PIK3CA FBXW7
14	cholangiocarcinoma	30.6	TP53 SMAD4 PTEN PIK3CA CDKN2A
15	gastric adenocarcinoma	30.5	TP53 SMAD4 PTEN PIK3CA FBXW7 CDKN2A
16	cervical squamous cell carcinoma	30.5	TP53 SMAD4 PTEN PIK3CA KMT2D KMT2C
17	cervix endometriosis	30.4	MAPK8IP1 CDKN2A
18	clear cell adenocarcinoma	30.4	TP53 SMAD4 PAX8 ARID1A
19	female reproductive endometrioid cancer	30.3	TP53 PTEN PIK3CA PAX8 ARID1A
20	human papillomavirus infectious disease	30.3	TP53 PTEN PIK3CA ICOSLG CDKN2A
21	lynch syndrome	30.3	U2AF1 TP53 SMAD4 PTEN PIK3CA FBXW7
22	serous cystadenocarcinoma	30.2	TP53 PTEN PIK3CA PAX8 CDKN2A ARID1A
23	fanconi anemia, complementation group a	30.2	U2AF1 TP53 PTEN KMT2D CDKN2A ARID1A
24	ovary adenocarcinoma	30.1	U2AF1 TP53 SLC25A16 SIGLEC5 PTEN PIK3CA
25	rectum adenocarcinoma	30.1	U2AF1 TP53 SMAD4 SLC25A16 SIGLEC5 PIK3CA
26	adenoid cystic carcinoma	30.1	TP53 PTEN PIK3CA KMT2C FBXW7 EP300
27	endocervical carcinoma	30.0	U2AF1 TP53 SLC25A16 SIGLEC5 PTEN PIK3CA
28	renal cell carcinoma, nonpapillary	29.7	U2AF1 TP53 SLC25A16 SIGLEC5 PTEN PIK3CA
29	high-grade astrocytoma	10.5	TP53 PTEN
30	endometrial cancer	10.5
31	vulvar seborrheic keratosis	10.5	PTEN CDKN2A
32	lung oat cell carcinoma	10.4	TP53 PTEN PIK3CA
33	vaginal carcinosarcoma	10.4	TP53 PIK3CA FBXW7
34	ovarian clear cell adenocarcinoma	10.4	TP53 PIK3CA ARID1A
35	bartholin's gland adenoid cystic carcinoma	10.4	PIK3CA EP300 ARID1A
36	clear cell adenofibroma	10.4	PIK3CA ARID1A
37	lobular neoplasia	10.4	TP53 PTEN PIK3CA
38	b-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	10.4	TP53 CDKN2A
39	hypertrophy of breast	10.4	TP53 PTEN PIK3CA
40	esophagus verrucous carcinoma	10.4	TP53 PIK3CA CDKN2A
41	verrucous carcinoma	10.4	TP53 PIK3CA CDKN2A
42	breast lobular carcinoma	10.4	TP53 PTEN PIK3CA
43	penile benign neoplasm	10.4	TP53 PIK3CA CDKN2A
44	keratinizing squamous cell carcinoma	10.4	TP53 PIK3CA CDKN2A
45	endometriosis of ovary	10.4	PTEN PIK3CA ARID1A
46	adenofibroma	10.4	TP53 PAX8 ARID1A
47	cervical endometrioid adenocarcinoma	10.4	U2AF1 FBXW7
48	acanthoma	10.4	TP53 PIK3CA CDKN2A
49	colon adenoma	10.4	TP53 SMAD4 PIK3CA
50	idh-wildtype glioblastoma	10.4	TP53 PTEN CDKN2A

Graphical network of the top 20 diseases related to Endocervical Adenocarcinoma:

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Symptoms & Phenotypes for Endocervical Adenocarcinoma

GenomeRNAi Phenotypes related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability in pancreas lineage	GR00235-A	9.16	ARID1A TP53
2	Increased sensitivity to paclitaxel	GR00112-A-0	8.96	SMAD4
3	Increased CDKN1A mRNA expression	GR00389-S-1	8.96	EP300 KMT2D
4	Increased BBC3 mRNA expression	GR00389-S-3	8.62	EP300 KMT2D

MGI Mouse Phenotypes related to Endocervical Adenocarcinoma:

⁴⁵ (show all 17)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.41	ARID1A CDKN2A DDX3X EP300 FAT1 FBXW7
2	nervous system	MP:0003631	10.35	ARID1A CDKN2A DDX3X EP300 FAT1 FBXW7
3	growth/size/body region	MP:0005378	10.34	ARID1A CDKN2A DDX3X EP300 FAT1 FBXW7
4	neoplasm	MP:0002006	10.27	ARID1A CDKN2A EP300 FBXW7 KMT2D PIK3CA
5	muscle	MP:0005369	10.22	ARID1A CDKN2A DDX3X EP300 FAT1 KMT2D
6	endocrine/exocrine gland	MP:0005379	10.22	ARID1A CDKN2A DDX3X EP300 FBXW7 MAPK8IP1
7	normal	MP:0002873	10.21	ARID1A DDX3X EP300 FBXW7 PAX8 PTEN
8	cellular	MP:0005384	10.21	ARID1A CDKN2A DDX3X EP300 FBXW7 KMT2C
9	embryo	MP:0005380	10.2	ARID1A CDKN2A DDX3X EP300 FBXW7 KMT2D
10	no phenotypic analysis	MP:0003012	10.15	ARID1A CDKN2A FAT1 KMT2C PAX8 PIK3CA
11	cardiovascular system	MP:0005385	10.13	ARID1A CDKN2A DDX3X EP300 FAT1 FBXW7
12	immune system	MP:0005387	10.07	ARID1A CDKN2A EP300 FAT1 FBXW7 ICOSLG
13	digestive/alimentary	MP:0005381	10.03	CDKN2A EP300 FBXW7 KMT2D PIK3CA PTEN
14	craniofacial	MP:0005382	10.01	ARID1A EP300 FAT1 FBXW7 KMT2D PAX8
15	reproductive system	MP:0005389	9.9	ARID1A CDKN2A DDX3X FBXW7 KMT2C MAPK8IP1
16	vision/eye	MP:0005391	9.7	ARID1A CDKN2A EP300 FAT1 FBXW7 KMT2C
17	mortality/aging	MP:0010768	9.5	ARID1A CDKN2A DDX3X EP300 FAT1 FBXW7

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Drugs & Therapeutics for Endocervical Adenocarcinoma

Drugs for Endocervical Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Fludarabine

Approved

Phase 1, Phase 2

75607-67-9, 21679-14-1

30751 657237

2

Aldesleukin

Approved

Phase 1, Phase 2

110942-02-4

3

Cyclophosphamide

Approved, Investigational

Phase 1, Phase 2

50-18-0, 6055-19-2

2907

4

Antiviral Agents

Phase 1, Phase 2

5

Anti-Retroviral Agents

Phase 1, Phase 2

6

Anti-Infective Agents

Phase 1, Phase 2

7

Anti-HIV Agents

Phase 1, Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Feasibility Study of E7 TCR-T Cell Induction Therapy for Locoregionally Advanced HPV-Associated Cancers	Not yet recruiting	NCT05639972	Phase 1, Phase 2	Conditioning, E7 TCR-T cells, and aldesleukin
2	InAdvance: Surveillance, Prevention, and Interception in a Population at Risk For Cancer	Not yet recruiting	NCT05463796

Search NIH Clinical Center for Endocervical Adenocarcinoma

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Genetic Tests for Endocervical Adenocarcinoma

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Anatomical Context for Endocervical Adenocarcinoma

Organs/tissues related to Endocervical Adenocarcinoma:

MalaCards : T Cells, Cervix, Lymph Node, Uterus, Ovary, Smooth Muscle, Liver

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Publications for Endocervical Adenocarcinoma

Articles related to Endocervical Adenocarcinoma:

(show top 50) (show all 556)

#	Title	Authors	PMID	Year
1	Distribution and incidence of atypical glandular lesions in cervical cytology focusing on the association with high-risk human papillomavirus subtypes. ⁶²	Abbas M...Bettendorf O	36419751	2023
2	Using Silva pattern system to predict prognosis and plan treatment of invasive endocervical adenocarcinoma: a single-center retrospective analysis. ⁶²	Li X...Qu P	36460984	2022
3	The regulation role and diagnostic value of fibrinogen-like protein 1 revealed by pan-cancer analysis. ⁶²	Yi W...Lv Z	36345363	2022
4	Predicting prognosis according to the updated WHO classification in patients with endocervical adenocarcinoma treated with surgery and radiotherapy. ⁶²	Cho WK...Kim BG	36047374	2022
5	Silva cumulative score and its relationship with prognosis in Endocervical adenocarcinoma. ⁶²	Li Y...Sun PL	36376880	2022
6	Adenocarcinoma of the uterine cervix, gastric-type (GAS): a review of the literature focused on pathology and multimodality imaging. ⁶²	Kerwin CM...Patel NU	36334123	2022
7	Patterns and risk factors of recurrence in low-risk early-stage cervical adenocarcinoma treated with surgery alone: implications on risk group stratification. ⁶²	Bae BK...Park W	36368708	2022
8	Benign stratified intraepithelial mucinous proliferation of the uterine cervix: Significance of a previously unreported potential mimic of SMILE. ⁶²	Arslanian E...Quddus MR	35988376	2022
9	Diagnostic utility of ThinPrep Imaging System® for detecting atypical glandular cells in cervical smear samples. ⁶²	Akca Y...Erkilic S	36308412	2022
10	Gastric-type adenocarcinoma of the cervix: Clinical outcomes and genomic drivers. ⁶²	Ehmann S...Friedman CF	36253302	2022
11	HPV-genotyping versus conventional cervical cytology as a screening method to detect dysplastic cervical epithelial changes. ⁶²	Abbas M...Bettendorf O	36280748	2022
12	hsa-mir-133a-2 promotes the proliferation and invasion of cervical cancer cells by targeting the LAMB3-mediated PI3K/ATK pathway. ⁶²	Sui X...Li X	36305754	2022
13	Fine needle aspiration of pancreatic lesions focusing on secondary tumors with emphasis of metastatic breast cancer: A clinicopathological study with follow-up. ⁶²	Chen MY...Xu Y	36281523	2022
14	Identification of a necroptosis-related prognostic gene signature associated with tumor immune microenvironment in cervical carcinoma and experimental verification. ⁶²	Sun K...Luo ZX	36253777	2022
15	RNPS1 functions as an oncogenic splicing factor in cervical cancer cells. ⁶²	Deka B...Singh KK	36300671	2022
16	Transmembrane protein 121 as a novel inhibitor of cervical cancer metastasis. ⁶²	Yang B...Fan X	35978921	2022
17	Neuroendocrine Carcinoma of the Uterine Cervix With Metastases to the Thyroid Gland: A Case Report and Clinical Pathological Review. ⁶²	Ortiz WJ...Cervantes M	36312683	2022
18	Gene signatures, immune infiltration, and drug sensitivity based on a comprehensive analysis of m6a RNA methylation regulators in cervical cancer. ⁶²	Lu X...Wang W	36058934	2022
19	Immune-related 3-lncRNA signature with prognostic connotation in a multi-cancer setting. ⁶²	Sherif S...Decock J	36180904	2022
20	Cytopathologic features of human papillomavirus-independent, gastric-type endocervical adenocarcinoma. ⁶²	Yeo MK...Suh KS	36128862	2022
21	Corrigendum to "False-Negative Pap Tests in Women with Biopsy-Proven Invasive Endocervical Adenocarcinoma/Adenocarcinoma In Situ: A Retrospective Analysis with Assessment of Inter-Observer Agreement" Journal of the American Society of Cytopathology 2021;11:3-12. ⁶²	Lin M...Okoye E	36114101	2022
22	Endocervical Adenocarcinoma: Comprehensive Histological Review and Re-classification of 123 Consecutive Cases According to the Updated World Health Organization Classification of Female Genital Tumors. ⁶²	Lee Y...Kim HS	36039458	2022
23	Analysis of postoperative adjuvant therapy in 102 patients with gastric-type mucinous carcinoma of the uterine cervix: A multi-institutional study. ⁶²	Nishio S...Ushijima K	35354541	2022
24	Necroptosis-related lncRNA signature predicts prognosis and immune response for cervical squamous cell carcinoma and endocervical adenocarcinomas. ⁶²	Lin Z...Zhao J	36175606	2022
25	Reproducibility of Morphologic Parameters of the International Endocervical Adenocarcinoma Criteria and Classification System and Correlation With Clinicopathologic Parameters: A Multi-Institutional Study. ⁶²	Bulutay P...Kapucuoglu N	34856570	2022
26	Independent validation of distinct clinicopathological features and prognosis among usual-type, mucinous-type and gastric-type endocervical adenocarcinoma categorised by new WHO classification (2020). ⁶²	Shi H...Lu B	35346505	2022
27	Cytology, High-Risk Human Papillomavirus Testing and Serum CA19-9 in a Large Cohort of Patients with Invasive Cervical Adenocarcinomas: Correlation with a New Pathogenetic Classification. ⁶²	Shi H...Lu B	36037112	2022
28	Clinical correlation of lymphovascular invasion and Silva pattern of invasion in early-stage endocervical adenocarcinoma: proposed binary Silva classification system. ⁶²	Stolnicu S...Abu-Rustum NR	35501168	2022
29	Ciliated/tubal-type in-situ and invasive endocervical adenocarcinoma: Report of three cases with limited follow-up and review of the literature. ⁶²	Marketkar S...Ruhul Quddus M	35782103	2022
30	Characterizing the extracellular matrix transcriptome of cervical, endometrial, and uterine cancers. ⁶²	Cook CJ...Fogg KC	35898192	2022
31	Establishment and validation of prognostic nomograms integrating histopathological features in patients with endocervical adenocarcinoma. ⁶²	Luo RZ...Liu LL	35999033	2022
32	A Snapshot of the Landscape of Endocervical Adenocarcinoma in Kenya: What Has HPV Got to Do with It? ⁶²	Wawire J...Quddus MR	36197776	2022
33	[Correlation of micropapillary patten, cribriform pattern and retraction clefting of endocervical adenocarcinoma with the Silva classification system and prognosis]. ⁶²	Li YM...Gao HW	35750638	2022
34	The splicing factor SF3B4 drives proliferation and invasion in cervical cancer by regulating SPAG5. ⁶²	Li Y...Kong B	35853859	2022
35	[Revised German guidelines on the diagnosis and treatment of carcinoma of the uterine cervix-what's new for pathologists in 2021?] ⁶²	Horn LC...Kommission zur Erstellung der S3-Leitlinie Zervixkarzinom	35191993	2022
36	Membranous and nuclear staining of CLDN18 in HPV-independent and HPV-associated endocervical adenocarcinomas. ⁶²	Du X...Yao Q	35861118	2022
37	Ovarian Metastasis by Gastric-type Endocervical Adenocarcinoma: A Clinicopathologic Description of 12 Cases. ⁶²	Lu B...Xu J	34347666	2022
38	Construction of a four-mRNA prognostic signature with its ceRNA network in CESC. ⁶²	Li L...Lv X	35739227	2022
39	Squamous and Glandular Epithelial Tumors of the Cervix: A Pragmatical Review Emphasizing Emerging Issues in Classification, Diagnosis, and Staging. ⁶²	Stolnicu S...Soslow RA	35715166	2022
40	Clear Cell Carcinoma (CCC) of the Cervix Is a Human Papillomavirus (HPV)-independent Tumor Associated With Poor Outcome: A Comprehensive Analysis of 58 Cases. ⁶²	Stolnicu S...Park KJ	34985047	2022
41	Pan‑cancer analyses reveal the regulation and clinical outcome association of PCLAF in human tumors. ⁶²	Liu X...Wu Z	35425993	2022
42	Comprehensive analysis of the exocytosis pathway genes in cervical cancer. ⁶²	Eswaran S...Kabekkodu SP	34995576	2022
43	ERBB3 methylation and immune infiltration in tumor microenvironment of cervical cancer. ⁶²	Yang X...Zhu W	35581263	2022
44	PTEN Loss and ARID1A Mutation in an HPV-positive Metastatic Adenocarcinoma Diagnosed Almost 18 yr After an Intact Cone Excision for Endocervical Adenocarcinoma In Situ. ⁶²	Aisagbonhi O...Fadare O	34282106	2022
45	Tumoral Morphologic Features From Cervical Biopsies That Are Predictive of a Negligible Risk for Nodal Metastasis and Tumor Recurrence in Usual-type Cervical Adenocarcinomas: A Multi-institutional Study. ⁶²	Wang Y...Zheng W	34753864	2022
46	Claudin-18 as a Promising Surrogate Marker for Endocervical Gastric-type Carcinoma. ⁶²	Kiyokawa T...Stolnicu S	34864774	2022
47	Endocervical adenocarcinoma in situ with ovarian metastases. ⁶²	Glennon K...Brennan D	35379705	2022
48	Association of recurrent APOBEC3B alterations with the prognosis of gastric-type cervical adenocarcinoma. ⁶²	Liao X...Shu Y	35151492	2022
49	Grading of endocervical adenocarcinoma: a novel prognostic system based on tumor budding and cell cluster size. ⁶²	Shi H...Lu B	34593968	2022
50	Gastric-phenotype Mucinous Carcinoma of the Fallopian Tube with Secondary Ovarian Involvement in a Woman with Peutz-Jeghers Syndrome: A Case Report. ⁶²	Bronte Anaut M...Guarch Troyas R	35466733	2022

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Genes for Endocervical Adenocarcinoma

Genes related to Endocervical Adenocarcinoma (0 elite genes):

(show all 39)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TP53	Tumor Protein P53	Protein Coding	20.96	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
2	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	11.82	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
3	ARID1A	AT-Rich Interaction Domain 1A	Protein Coding	11.6	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
4	PTEN	Phosphatase And Tensin Homolog	Protein Coding	11.6	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
5	KMT2C	Lysine Methyltransferase 2C	Protein Coding	11.17	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
6	EP300	E1A Binding Protein P300	Protein Coding	11.05	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
7	SMAD4	SMAD Family Member 4	Protein Coding	10.82	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
8	FBXW7	F-Box And WD Repeat Domain Containing 7	Protein Coding	10.81	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
9	KMT2D	Lysine Methyltransferase 2D	Protein Coding	10.56	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
10	FAT1	FAT Atypical Cadherin 1	Protein Coding	10.36	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
11	DDX3X	DEAD-Box Helicase 3 X-Linked	Protein Coding	9.79	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
12	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	6.68	DISEASES inferred ¹⁴
13	U2AF1	U2 Small Nuclear RNA Auxiliary Factor 1	Protein Coding	6.6	DISEASES inferred ¹⁴ ¹⁴
14	SLC25A16	Solute Carrier Family 25 Member 16	Protein Coding	6.52	DISEASES inferred ¹⁴
15	TCEA3	Transcription Elongation Factor A3	Protein Coding	6.5	GeneCards inferred via : Disorders (show sections)
16	SIGLEC5	Sialic Acid Binding Ig Like Lectin 5	Protein Coding	6.33	DISEASES inferred ¹⁴ ¹⁴
17	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	6	DISEASES inferred ¹⁴ ¹⁴
18	MAPK8IP1	Mitogen-Activated Protein Kinase 8 Interacting Protein 1	Protein Coding	5.93	DISEASES inferred ¹⁴
19	PAX8	Paired Box 8	Protein Coding	5.86	DISEASES inferred ¹⁴
20	MUC6	Mucin 6, Oligomeric Mucus/Gel-Forming	Protein Coding	5.84	DISEASES inferred ¹⁴
21	CD274	CD274 Molecule	Protein Coding	5.76	DISEASES inferred ¹⁴
22	CD8A	CD8a Molecule	Protein Coding	5.59	DISEASES inferred ¹⁴
23	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	5.54	DISEASES inferred ¹⁴
24	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	5.54	DISEASES inferred ¹⁴
25	KRT7	Keratin 7	Protein Coding	5.53	DISEASES inferred ¹⁴
26	ESR1	Estrogen Receptor 1	Protein Coding	5.51	DISEASES inferred ¹⁴
27	INSM1	INSM Transcriptional Repressor 1	Protein Coding	5.51	DISEASES inferred ¹⁴
28	PDCD1	Programmed Cell Death 1	Protein Coding	5.29	DISEASES inferred ¹⁴
29	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	5.25	DISEASES inferred ¹⁴
30	PGR	Progesterone Receptor	Protein Coding	5.23	DISEASES inferred ¹⁴
31	CTNNB1	Catenin Beta 1	Protein Coding	5.22	DISEASES inferred ¹⁴
32	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	5.21	DISEASES inferred ¹⁴
33	GAPDH	Glyceraldehyde-3-Phosphate Dehydrogenase	Protein Coding	5.14	DISEASES inferred ¹⁴
34	GATA3	GATA Binding Protein 3	Protein Coding	5.13	DISEASES inferred ¹⁴
35	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	5.12	DISEASES inferred ¹⁴
36	MSH6	MutS Homolog 6	Protein Coding	5.12	DISEASES inferred ¹⁴
37	CD4	CD4 Molecule	Protein Coding	5.08	DISEASES inferred ¹⁴
38	MIR4677	MicroRNA 4677	RNA Gene	5.05	DISEASES inferred ¹⁴
39	LAG3	Lymphocyte Activating 3	Protein Coding	5.05	DISEASES inferred ¹⁴

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Variations for Endocervical Adenocarcinoma

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Expression for Endocervical Adenocarcinoma

Search GEO for disease gene expression data for Endocervical Adenocarcinoma.

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Pathways for Endocervical Adenocarcinoma

Pathways related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 18)

#	Super pathways	Score	Top Affiliating Genes
1	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.68	TP53 SMAD4 PIK3CA EP300 DDX3X
2	Endometrial cancer ⁷⁴ Show member pathways Chromosomal and microsatellite instability in colorectal cancer ⁷⁴ Melanoma ⁷⁴ Non-small cell lung cancer ⁷⁴ Pancreatic adenocarcinoma pathway ⁷⁴ Signal transduction PTEN pathway ²²	12.55	TP53 SMAD4 PTEN PIK3CA CDKN2A
3	Malignant pleural mesothelioma ⁷⁴	12.5	TP53 PTEN PIK3CA KMT2C CDKN2A
4	Breast cancer pathway ⁷⁴ Show member pathways Embryonic stem cell pluripotency pathways ⁷⁴	12.3	TP53 SMAD4 PTEN PIK3CA
5	Cell cycle ⁷⁴ Show member pathways G1 to S cell cycle control ⁷⁴	12.08	TP53 SMAD4 EP300 CDKN2A
6	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	11.94	CDKN2A PIK3CA PTEN TP53
7	Integrated breast cancer pathway ⁷⁴	11.91	TP53 SMAD4 PTEN EP300
8	Small cell lung cancer ⁷⁴	11.73	TP53 PTEN PIK3CA
9	Senescence and autophagy in cancer ⁷⁴	11.73	TP53 SMAD4 PTEN CDKN2A
10	DNA damage response (only ATM dependent) ⁷⁴	11.68	TP53 SMAD4 PTEN PIK3CA
11	Transcription_P53 signaling pathway ²²	11.51	TP53 SMAD4 EP300 CDKN2A
12	Copper homeostasis ⁷⁴ Show member pathways Copper metabolism ⁷⁴ Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) ⁶⁶	11.49	TP53 PTEN PIK3CA
13	HIF1Alpha Pathway ⁶⁴	11.43	TP53 EP300 CDKN2A
14	16p11.2 proximal deletion syndrome ⁷⁴	11.43	TP53 PTEN KMT2D KMT2C
15	AP-1 transcription factor network ⁶¹	11.3	TP53 PTEN EP300 CDKN2A
16	Head and neck squamous cell carcinoma ⁷⁴	11.3	TP53 SMAD4 PTEN PIK3CA FAT1 CDKN2A
17	Pathways affected in adenoid cystic carcinoma ⁷⁴	10.96	TP53 PTEN PIK3CA KMT2C FBXW7 EP300
18	Hematopoietic stem cell gene regulation by GABP alpha/beta complex ⁷⁴	10.8	SMAD4 PTEN EP300

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GO Terms for Endocervical Adenocarcinoma

Biological processes related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell growth	GO:0030308	9.76	TP53 SMAD4 DDX3X CDKN2A
2	protein destabilization	GO:0031648	9.65	FBXW7 EP300 CDKN2A
3	protein stabilization	GO:0050821	9.61	TP53 PTEN FBXW7 EP300 CDKN2A
4	transcription initiation-coupled chromatin remodeling	GO:0045815	9.1	TP53 EP300 ARID1A

Molecular functions related to Endocervical Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA binding	GO:0003677	9.6	TP53 TCEA3 SMAD4 PAX8 KMT2D KMT2C

Sources

Sources for Endocervical Adenocarcinoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: END075 MIFTS: 39	Endocervical Adenocarcinoma Categories: Cancer diseases, Reproductive diseases	Data Licensing For inquiries, contact: [email protected]
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