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MCID: END029
MIFTS: 34

Endocervical Carcinoma

Categories: Cancer diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Endocervical Carcinoma

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MalaCards integrated aliases for Endocervical Carcinoma:

Name: Endocervical Carcinoma 12 15 70
Carcinoma of the Endocervix 12
Carcinoma of Endocervix 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:7519
NCIt 50 C28327
SNOMED-CT 67 372098004
ICD10 32 C53.0
UMLS 70 C1299237
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Summaries for Endocervical Carcinoma

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Disease Ontology : 12 A cervix carcinoma that is located in the endocervix.

MalaCards based summary : Endocervical Carcinoma, also known as carcinoma of the endocervix, is related to squamous cell papilloma and papilloma. An important gene associated with Endocervical Carcinoma is U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include endocervix, cervix and uterus, and related phenotype is no phenotypic analysis.

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Related Diseases for Endocervical Carcinoma

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Diseases related to Endocervical Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 400)
# Related Disease Score Top Affiliating Genes
1 squamous cell papilloma 30.6 TP53 CDKN2A
2 papilloma 30.5 TP53 KRT7 ERBB2 CDKN2A
3 endocervical adenocarcinoma 30.3 ZNF573 ZNF441 U2AF1 TP53 SLC25A16 PIK3CA
4 adenocarcinoma in situ 30.3 U2AF1 PAX8 KRT7 INSM1 CEACAM5 CDKN2A
5 adenocarcinoma 30.3 TP53 PIK3CA KRT7 ERBB2 CEACAM5 CDKN2A
6 adenosquamous carcinoma 30.2 TP53 PIK3CA KRT7 CEACAM5 CDKN2A
7 small cell carcinoma 30.1 TP53 KRT7 INSM1 ERBB2 CDKN2A
8 cervical adenocarcinoma 30.0 TP53 KRT7 ESR1 ERBB2 CEACAM5 CDKN2A
9 suppressor of tumorigenicity 3 30.0 TP53 CDKN2A
10 cervical basaloid squamous cell carcinoma 10.5 KRT7 CDKN2A
11 leukoplakia of penis 10.5 KRT7 CEACAM5
12 mucoepidermoid esophageal carcinoma 10.5 TP53 CEACAM5
13 anal canal paget's disease 10.5 KRT7 CDKN2A
14 vulvar intraepithelial neoplasia 10.5 TP53 CDKN2A
15 anal paget's disease 10.5 KRT7 CEACAM5
16 ureter adenocarcinoma 10.5 KRT7 CEACAM5
17 vulvar eccrine porocarcinoma 10.5 CEACAM5 CDKN2A
18 fallopian tube endometriosis 10.5 PGR CEACAM5
19 cervical adenoid cystic carcinoma 10.5 KRT7 CDKN2A
20 endometrial squamous cell carcinoma 10.5 PGR CDKN2A
21 vaginal glandular tumor 10.5 PGR CEACAM5
22 bladder benign neoplasm 10.5 PAX8 KRT7
23 malignant acrospiroma 10.5 KRT7 CEACAM5
24 nephrogenic adenoma of urinary bladder 10.5 PAX8 KRT7
25 cervical mucinous adenocarcinoma 10.5 MUC6 KRT7
26 rete testis neoplasm 10.5 PAX8 KRT7
27 esophagus verrucous carcinoma 10.5 TP53 CDKN2A
28 adult teratoma 10.5 TP53 CEACAM5
29 wolffian duct adenoma 10.5 PAX8 KRT7
30 rete testis adenocarcinoma 10.5 PAX8 KRT7
31 maxillary sinus benign neoplasm 10.5 CEACAM5 CDKN2A
32 pancreatic serous cystadenocarcinoma 10.5 KRT7 CEACAM5
33 sebaceous breast carcinoma 10.5 ERBB2 CEACAM5
34 uterine corpus adenosarcoma 10.5 PGR ESR1
35 cutaneous mucoepidermoid carcinoma 10.5 KRT7 CEACAM5
36 chronic tympanitis 10.5 PGR ESR1
37 pancreatic serous cystadenoma 10.5 MUC6 CEACAM5
38 mucocele of appendix 10.5 PGR CEACAM5
39 vulvar syringoma 10.5 PGR ESR1
40 female urethral cancer 10.5 KRT7 CEACAM5
41 eccrine mixed tumor of skin 10.5 ERBB2 CEACAM5
42 early invasive cervical adenocarcinoma 10.5 INSM1 CDKN2A
43 basaloid lung carcinoma 10.5 TP53 PGR
44 bartholin's gland carcinoma 10.5 PAX8 KRT7
45 human papillomavirus infectious disease 10.5 TP53 CDKN2A
46 eccrine adenocarcinoma 10.5 KRT7 CEACAM5
47 mucinous intrahepatic cholangiocarcinoma 10.5 MUC6 KRT7
48 anus basaloid carcinoma 10.5 PIK3CA KRT7
49 mucinous ovarian cystadenoma 10.5 KRT7 CEACAM5
50 rectosigmoid junction neoplasm 10.5 KRT7 CEACAM5

Graphical network of the top 20 diseases related to Endocervical Carcinoma:



Diseases related to Endocervical Carcinoma
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Symptoms & Phenotypes for Endocervical Carcinoma

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MGI Mouse Phenotypes related to Endocervical Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.23 CDKN2A ESR1 GATA3 INSM1 PAX8 PGR
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Drugs & Therapeutics for Endocervical Carcinoma

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Search Clinical Trials , NIH Clinical Center for Endocervical Carcinoma

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Genetic Tests for Endocervical Carcinoma

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Anatomical Context for Endocervical Carcinoma

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The Foundational Model of Anatomy Ontology organs/tissues related to Endocervical Carcinoma:

19
Endocervix

MalaCards organs/tissues related to Endocervical Carcinoma:

40
Cervix, Uterus, Thyroid, Ovary
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Publications for Endocervical Carcinoma

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Articles related to Endocervical Carcinoma:

(show all 48)
# Title Authors PMID Year
1
Transcriptome profiling of gastric-type endocervical adenocarcinomas identifies key signaling pathways for tumor progression. 61
32317172 2020
2
A case of non-HPV related primary endometrioid adenocarcinoma of the cervix. 61
32405523 2020
3
Gastric-Type Adenocarcinoma of the Uterine Cervix: Magnetic Resonance Imaging Features, Clinical Outcomes, and Prognostic Factors. 61
29683881 2018
4
Case 21-2017. A 28-Year-Old Pregnant Woman with Endocervical Carcinoma. 61
28700849 2017
5
Glandular epithelial abnormalities on thinprep® pap tests: Clinical and cytohistologic correlation. 61
26878832 2016
6
Foamy gland changes in gastric-type endocervical neoplasia. 61
26517626 2015
7
Invasive endocervical adenocarcinoma: a new pattern-based classification system with important clinical significance. 61
25724003 2015
8
Long-term survival after total pelvic exenteration in a patient with recurrent cervical carcinoma: A case report. 61
28913015 2014
9
The spectrum of cervical glandular neoplasia and issues in differential diagnosis. 61
24678677 2014
10
Are women with endocervical adenocarcinoma at risk for lynch syndrome? Evaluation of 101 cases including unusual subtypes and lower uterine segment tumors. 61
22833088 2012
11
Cervical adenocarcinoma: a retrospective clinicopathologic study of 16 cases. 61
22990556 2012
12
Ovarian neoplasia associated with localized endocervical carcinoma. 61
21131831 2011
13
Detection of HPV-DNA by a PCR-based method in formalin-fixed, paraffin-embedded tissue from rare endocervical carcinoma types. 61
19625948 2010
14
Synchronous primary carcinoma in 5 different organs of a female genital tract: an unusual case and review of the literature. 61
19509592 2009
15
Carcinoma of the lower uterine segment: a newly described association with Lynch syndrome. 61
19001318 2008
16
Triple synchronous primary cervical, endometrial and ovarian cancer with four different histologic patterns. 61
17541616 2007
17
Thyroid transcription factor-1 expression in endometrial and endocervical adenocarcinomas. 61
18059234 2007
18
Mucinous expression in benign and neoplastic glandular lesions of the uterine cervix. 61
17090193 2006
19
Endometrial and endocervical secretion: the search for histochemical differentiation. 61
16637511 2006
20
Assessment of reliability endometrial brush cytology in detection etiology of late postmenopausal bleedings. 61
15221320 2004
21
[Cystic adenoid carcinoma of the endocervix (or cylindroma of the uterine cervix). Exclusive laparoscopic vaginal treatment]. 61
11319471 2001
22
Familial papillary serous carcinoma of the cervix, peritoneum, and ovary: a report of the first case. 61
9740708 1998
23
Analysis of human papillomavirus infection and molecular alterations in adenocarcinoma of the cervix. 61
9556417 1998
24
[Immunohistochemical characterization and ultrastructural features of cervical squamous cell carcinoma of ectocervical and endocervical (cambial cell or metaplastic) genesis]. 61
8712934 1996
25
Treatment selection for "bulky" carcinoma of the endocervix. 61
1612970 1992
26
Bulky endocervical carcinoma: a 23-year experience. 61
1612949 1992
27
Endocervical carcinoma and precursor lesions: c-myc expression and the demonstration of field changes. 61
1752978 1991
28
[Cancer metastasis causing superior vena cava syndrome in the right heart]. 61
2011388 1991
29
Endocervical carcinoma. 61
2067992 1991
30
Localization of carcinoembryonic antigen in uterine cervical neoplasia. 61
2079363 1990
31
Cervical adenocarcinoma in young women: possible relationship to microglandular hyperplasia and use of oral contraceptives. 61
2726119 1989
32
[Biometric research in the diagnosis of precancerous states and endocervical cancer]. 61
2629663 1989
33
Prospective comparison of ultrasound and computed tomography in the evaluation of the size of the uterus: can these methods be used for intracavitary treatment planning of carcinoma of the uterus? 61
3553114 1987
34
Intermediate filaments in endometrial and endocervical carcinomas. The diagnostic utility of vimentin patterns. 61
2426982 1986
35
Results of radiotherapy in carcinoma of cervix stages I and II: the impact of involvement of endocervix. 61
4035000 1985
36
Endocervical carcinoma: a study of 23 patients with clinical-pathological correlation. 61
6086469 1984
37
Verrucous carcinoma of the endocervix. 61
6888836 1983
38
Cost effectiveness of population screening and rescreening for cervical cancer in the Netherlands. 61
6792845 1981
39
Endocervical adenocarcinoma and vulval Paget's disease: a significant association. 61
6254556 1980
40
[The dissemination of endocervical squamous carcinoma cell during cone biopsy.] [(author's transl)]. 61
7416806 1980
41
Recurrent postmenopausal bleeding. 61
609995 1977
42
[Colposcopic diagnosis of endocervical carcinoma]. 61
4452002 1974
43
Detection of early endocervical carcinoma using colposcopy. 61
5441271 1970
44
[Clinical aspects of endocervical carcinoma]. 61
5527782 1970
45
[A case of endocervical carcinoma]. 61
5601860 1967
46
[Diagnostic difficulties in endocervical carcinoma of the uterine neck]. 61
13771556 1960
47
[Early stages of invasion of superficial endocervical carcinoma]. 61
13224119 1954
48
The clinical usefulness of the vaginal smear. 61
15397538 1949
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Variations for Endocervical Carcinoma

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Expression for Endocervical Carcinoma

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Search GEO for disease gene expression data for Endocervical Carcinoma.
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Pathways for Endocervical Carcinoma

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Pathways related to Endocervical Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Endometrial cancer 36
Show member pathways
 12.64 TP53 PIK3CA PAX8 ERBB2 CDKN2A
2
Pathways in cancer 36
12.52 TP53 PIK3CA PAX8 ESR1 ERBB2 CDKN2A
3
Glioma 36
Show member pathways
 12.37 TP53 PIK3CA ESR1 ERBB2 CDKN2A
4
Gastric cancer 36
Show member pathways
 12.1 TP53 PIK3CA PGR ESR1 ERBB2 CDKN2A
5
Proteoglycans in cancer 36
12.02 TP53 PIK3CA ESR1 ERBB2
6
DNA Damage Response (only ATM dependent) 1
11.62 TP53 PIK3CA ERBB2 CDKN2A
7
Bladder cancer 36 1
11.52 TP53 ERBB2 CDKN2A
8
Signaling by ERBB4 65
Show member pathways
 11.49 PIK3CA PGR ESR1 ERBB2
9
Central carbon metabolism in cancer 36
11.48 TP53 PIK3CA ERBB2
10
Pathways Affected in Adenoid Cystic Carcinoma 1
11.43 TP53 PIK3CA ERBB2
11
Platinum drug resistance 36
10.79 TP53 PIK3CA ERBB2 CDKN2A
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GO Terms for Endocervical Carcinoma

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Biological processes related to Endocervical Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 10.03 ZNF573 ZNF441 TP53 PGR PAX8 GATA3
2 positive regulation of protein kinase B signaling GO:0051897 9.67 PIK3CA GATA3 ESR1 ERBB2
3 mesonephros development GO:0001823 9.51 PAX8 GATA3
4 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.49 TP53 ESR1
5 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.48 TP53 ESR1
6 intracellular steroid hormone receptor signaling pathway GO:0030518 9.46 PGR ESR1
7 otic vesicle development GO:0071599 9.4 PAX8 GATA3
8 norepinephrine biosynthetic process GO:0042421 9.32 INSM1 GATA3
9 negative regulation of immature T cell proliferation in thymus GO:0033088 9.26 ERBB2 CDKN2A
10 positive regulation of thyroid hormone generation GO:2000611 9.16 PAX8 GATA3
11 phosphatidylinositol 3-kinase signaling GO:0014065 9.13 PIK3CA GATA3 ERBB2
12 positive regulation of cell cycle arrest GO:0071158 8.8 TP53 INSM1 CDKN2A

Molecular functions related to Endocervical Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.91 ZNF573 ZNF441 TP53 PGR PAX8 GATA3
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.7 ZNF573 TP53 PGR PAX8 INSM1 GATA3
3 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.65 TP53 PGR PAX8 GATA3 ESR1
4 DNA binding GO:0003677 9.61 ZNF573 ZNF441 TP53 PGR PAX8 INSM1
5 MDM2/MDM4 family protein binding GO:0097371 9.32 TP53 CDKN2A
6 DNA-binding transcription factor activity GO:0003700 9.1 TP53 PGR PAX8 INSM1 GATA3 ESR1
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Sources for Endocervical Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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