MCID: END029
MIFTS: 34

Endocervical Carcinoma

Categories: Cancer diseases, Reproductive diseases
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Aliases & Classifications for Endocervical Carcinoma

MalaCards integrated aliases for Endocervical Carcinoma:

Name: Endocervical Carcinoma 11 14 71
Carcinoma of the Endocervix 11
Carcinoma of Endocervix 11

Classifications:



External Ids:

Disease Ontology 11 DOID:7519
SNOMED-CT 68 372098004
ICD10 31 C53.0
UMLS 71 C1299237

Summaries for Endocervical Carcinoma

Disease Ontology: 11 A cervix carcinoma that is located in the endocervix.

MalaCards based summary: Endocervical Carcinoma, also known as carcinoma of the endocervix, is related to endocervical adenocarcinoma and verrucous carcinoma. An important gene associated with Endocervical Carcinoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Hepatocyte growth factor receptor signaling and Breast cancer pathway. Affiliated tissues include endocervix, cervix and uterus, and related phenotypes are Decreased viability and Decreased viability in pancreas lineage

Related Diseases for Endocervical Carcinoma

Diseases related to Endocervical Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 574)
# Related Disease Score Top Affiliating Genes
1 endocervical adenocarcinoma 31.3 U2AF1 TP53 SLC25A16 SIGLEC5 PIK3CA PDCD1
2 verrucous carcinoma 30.7 TP53 PIK3CA CDKN2A
3 papilloma 30.6 TP53 KRT7 ERBB2 CDKN2A
4 small cell carcinoma 30.5 TP53 KRT7 CEACAM5
5 adenoid cystic carcinoma 30.5 TP53 PIK3CA KRT7 ERBB2 CDKN2A
6 adenocarcinoma 30.4 TP53 PIK3CA KRT7 ERBB2 CEACAM5 CDKN2A
7 adenosquamous carcinoma 30.3 MAPK8IP1 KRT7 INSM1 CEACAM5
8 adenocarcinoma in situ 30.2 U2AF1 TP53 MUC6 MAPK8IP1 KRT7 INSM1
9 cervical adenocarcinoma 30.1 TP53 MAPK8IP1 KRT7 INSM1 ESR1 CEACAM5
10 suppressor of tumorigenicity 3 29.9 TP53 CDKN2A
11 cervical basaloid squamous cell carcinoma 10.5 KRT7 CDKN2A
12 b-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) 10.5 TP53 CDKN2A
13 mucoepidermoid esophageal carcinoma 10.5 TP53 CEACAM5
14 inverted transitional papilloma 10.5 KRT7 CDKN2A
15 early invasive cervical adenocarcinoma 10.5 INSM1 CDKN2A
16 vagina leiomyoma 10.5 CEACAM5 CDKN2A
17 anal canal paget's disease 10.5 KRT7 CDKN2A
18 endometrial transitional cell carcinoma 10.5 KRT7 CDKN2A
19 bartholin's gland adenoma 10.5 TP53 ESR1
20 bartholin's gland benign neoplasm 10.5 TP53 ESR1
21 vestibular gland benign neoplasm 10.5 TP53 ESR1
22 vulvar eccrine porocarcinoma 10.5 CEACAM5 CDKN2A
23 leukoplakia of penis 10.5 KRT7 CEACAM5
24 urethra clear cell adenocarcinoma 10.5 PAX8 KRT7
25 urethra adenocarcinoma 10.5 PAX8 KRT7
26 cervix endometriosis 10.5 MAPK8IP1 CDKN2A
27 mixed glioma 10.5 TP53 SIGLEC5 CDKN2A
28 vulva verrucous carcinoma 10.5 PDCD1 CD274
29 nephrogenic adenoma of urinary bladder 10.5 PAX8 KRT7
30 nephrogenic adenoma 10.5 PAX8 KRT7
31 rete testis adenoma 10.5 PAX8 KRT7
32 mucinous cystadenofibroma 10.5 PAX8 KRT7
33 eccrine mixed tumor of skin 10.5 ERBB2 CEACAM5
34 mucinous cystadenocarcinoma of pancreas 10.5 MUC6 CEACAM5
35 bladder benign neoplasm 10.5 PAX8 KRT7
36 urethral villous adenoma 10.5 KRT7 CEACAM5
37 apocrine adenosis of breast 10.5 TP53 ERBB2
38 necrotizing sialometaplasia 10.5 TP53 KRT7
39 urethra cancer 10.4 PAX8 KRT7
40 rete testis neoplasm 10.4 PAX8 KRT7
41 male urethral cancer 10.4 TP53 KRT7 CDKN2A
42 adult teratoma 10.4 TP53 CEACAM5
43 anal paget's disease 10.4 KRT7 CEACAM5
44 nipple carcinoma 10.4 ESR1 ERBB2
45 gastric signet ring cell adenocarcinoma 10.4 SIGLEC5 KRT7
46 bone squamous cell carcinoma 10.4 TP53 CDKN2A CD274
47 breast mucinous cystadenocarcinoma 10.4 ESR1 ERBB2
48 wolffian duct adenoma 10.4 PAX8 KRT7
49 breast fibroadenosis 10.4 ESR1 ERBB2
50 rete testis adenocarcinoma 10.4 PAX8 KRT7

Graphical network of the top 20 diseases related to Endocervical Carcinoma:



Diseases related to Endocervical Carcinoma

Symptoms & Phenotypes for Endocervical Carcinoma

GenomeRNAi Phenotypes related to Endocervical Carcinoma according to GeneCards Suite gene sharing:

25 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 10 PIK3CA
2 Decreased viability GR00055-A-2 10 PIK3CA
3 Decreased viability GR00173-A 10 MAPK8IP1
4 Decreased viability GR00221-A-1 10 CDKN2A ESR1 PIK3CA
5 Decreased viability GR00221-A-2 10 ESR1 PIK3CA
6 Decreased viability GR00221-A-3 10 CDKN2A ERBB2
7 Decreased viability GR00221-A-4 10 CDKN2A ERBB2 ESR1 MAPK8IP1 PIK3CA
8 Decreased viability GR00301-A 10 MAPK8IP1
9 Decreased viability GR00342-S-3 10 MAPK8IP1
10 Decreased viability GR00386-A-1 10 ESR1 MAPK8IP1
11 Decreased viability GR00402-S-2 10 ESR1 MAPK8IP1 PIK3CA
12 Decreased viability in pancreas lineage GR00235-A 8.62 KRT7 TP53

MGI Mouse Phenotypes related to Endocervical Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 CD274 CDKN2A CEACAM5 CT45A10 ERBB2 ESR1
2 neoplasm MP:0002006 9.92 CDKN2A CEACAM5 ERBB2 ESR1 PDCD1 PIK3CA
3 no phenotypic analysis MP:0003012 9.86 CD274 CDKN2A ESR1 INSM1 PAX8 PIK3CA
4 endocrine/exocrine gland MP:0005379 9.7 CD8A CDKN2A CEACAM5 ERBB2 ESR1 INSM1
5 cellular MP:0005384 9.47 CD274 CD8A CDKN2A CEACAM5 ERBB2 ESR1

Drugs & Therapeutics for Endocervical Carcinoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 InAdvance: Surveillance, Prevention, and Interception in a Population at Risk For Cancer Not yet recruiting NCT05463796

Search NIH Clinical Center for Endocervical Carcinoma

Genetic Tests for Endocervical Carcinoma

Anatomical Context for Endocervical Carcinoma

Organs/tissues related to Endocervical Carcinoma:

FMA: Endocervix
MalaCards : Cervix, Uterus, Ovary, Thyroid, Heart, Skin

Publications for Endocervical Carcinoma

Articles related to Endocervical Carcinoma:

(show top 50) (show all 55)
# Title Authors PMID Year
1
[Correlation of micropapillary patten, cribriform pattern and retraction clefting of endocervical adenocarcinoma with the Silva classification system and prognosis]. 62
35750638 2022
2
Fertility Sparing Treatment in Gastric-Type Endocervical Carcinoma. 62
34680326 2021
3
A review and case report of enigmatic superficial endometrial spread of cancer of the uterine cervix: Need for vigilance in the primary care setting. 62
34760782 2021
4
Immunohistochemical and genetic characteristics of HPV-associated endocervical carcinoma with an invasive stratified mucin-producing carcinoma (ISMC) component. 62
34103667 2021
5
A retrospective study on incidence, diagnosis, and clinical outcome of gastric-type endocervical adenocarcinoma in a single institution. 62
34332600 2021
6
Transcriptome profiling of gastric-type endocervical adenocarcinomas identifies key signaling pathways for tumor progression. 62
32317172 2020
7
A case of non-HPV related primary endometrioid adenocarcinoma of the cervix. 62
32405523 2020
8
Gastric-Type Adenocarcinoma of the Uterine Cervix: Magnetic Resonance Imaging Features, Clinical Outcomes, and Prognostic Factors. 62
29683881 2018
9
Case 21-2017. A 28-Year-Old Pregnant Woman with Endocervical Carcinoma. 62
28700849 2017
10
Glandular epithelial abnormalities on thinprep® pap tests: Clinical and cytohistologic correlation. 62
26878832 2016
11
Foamy gland changes in gastric-type endocervical neoplasia. 62
26517626 2015
12
Invasive endocervical adenocarcinoma: a new pattern-based classification system with important clinical significance. 62
25724003 2015
13
Long-term survival after total pelvic exenteration in a patient with recurrent cervical carcinoma: A case report. 62
28913015 2014
14
The spectrum of cervical glandular neoplasia and issues in differential diagnosis. 62
24678677 2014
15
Are women with endocervical adenocarcinoma at risk for lynch syndrome? Evaluation of 101 cases including unusual subtypes and lower uterine segment tumors. 62
22833088 2012
16
Cervical adenocarcinoma: a retrospective clinicopathologic study of 16 cases. 62
22990556 2012
17
Ovarian neoplasia associated with localized endocervical carcinoma. 62
21131831 2011
18
Detection of HPV-DNA by a PCR-based method in formalin-fixed, paraffin-embedded tissue from rare endocervical carcinoma types. 62
19625948 2010
19
Synchronous primary carcinoma in 5 different organs of a female genital tract: an unusual case and review of the literature. 62
19509592 2009
20
Carcinoma of the lower uterine segment: a newly described association with Lynch syndrome. 62
19001318 2008
21
Triple synchronous primary cervical, endometrial and ovarian cancer with four different histologic patterns. 62
17541616 2007
22
Thyroid transcription factor-1 expression in endometrial and endocervical adenocarcinomas. 62
18059234 2007
23
Mucinous expression in benign and neoplastic glandular lesions of the uterine cervix. 62
17090193 2006
24
Endometrial and endocervical secretion: the search for histochemical differentiation. 62
16637511 2006
25
Assessment of reliability endometrial brush cytology in detection etiology of late postmenopausal bleedings. 62
15221320 2004
26
[Cystic adenoid carcinoma of the endocervix (or cylindroma of the uterine cervix). Exclusive laparoscopic vaginal treatment]. 62
11319471 2001
27
Familial papillary serous carcinoma of the cervix, peritoneum, and ovary: a report of the first case. 62
9740708 1998
28
Analysis of human papillomavirus infection and molecular alterations in adenocarcinoma of the cervix. 62
9556417 1998
29
[Immunohistochemical characterization and ultrastructural features of cervical squamous cell carcinoma of ectocervical and endocervical (cambial cell or metaplastic) genesis]. 62
8712934 1996
30
Bulky endocervical carcinoma: a 23-year experience. 62
1612949 1992
31
Treatment selection for "bulky" carcinoma of the endocervix. 62
1612970 1992
32
Endocervical carcinoma and precursor lesions: c-myc expression and the demonstration of field changes. 62
1752978 1991
33
Endocervical carcinoma. 62
2067992 1991
34
[Cancer metastasis causing superior vena cava syndrome in the right heart]. 62
2011388 1991
35
Localization of carcinoembryonic antigen in uterine cervical neoplasia. 62
2079363 1990
36
Cervical adenocarcinoma in young women: possible relationship to microglandular hyperplasia and use of oral contraceptives. 62
2726119 1989
37
[Biometric research in the diagnosis of precancerous states and endocervical cancer]. 62
2629663 1989
38
Prospective comparison of ultrasound and computed tomography in the evaluation of the size of the uterus: can these methods be used for intracavitary treatment planning of carcinoma of the uterus? 62
3553114 1987
39
Intermediate filaments in endometrial and endocervical carcinomas. The diagnostic utility of vimentin patterns. 62
2426982 1986
40
Results of radiotherapy in carcinoma of cervix stages I and II: the impact of involvement of endocervix. 62
4035000 1985
41
Endocervical carcinoma: a study of 23 patients with clinical-pathological correlation. 62
6086469 1984
42
Skin calcium-binding protein in squamous metaplasia of human uterine cervix. 62
6364823 1984
43
Verrucous carcinoma of the endocervix. 62
6888836 1983
44
Cost effectiveness of population screening and rescreening for cervical cancer in the Netherlands. 62
6792845 1981
45
Endocervical adenocarcinoma and vulval Paget's disease: a significant association. 62
6254556 1980
46
[The dissemination of endocervical squamous carcinoma cell during cone biopsy.] [(author's transl)]. 62
7416806 1980
47
Clear cell carcinoma of the ovary: light and electron microscopic studies. 62
589565 1977
48
Recurrent postmenopausal bleeding. 62
609995 1977
49
[Colposcopic diagnosis of endocervical carcinoma]. 62
4452002 1974
50
Detection of early endocervical carcinoma using colposcopy. 62
5441271 1970

Variations for Endocervical Carcinoma

Expression for Endocervical Carcinoma

Search GEO for disease gene expression data for Endocervical Carcinoma.

Pathways for Endocervical Carcinoma

Pathways related to Endocervical Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.19 TP53 PIK3CA ESR1 ERBB2
2
Show member pathways
12.17 TP53 PIK3CA ESR1 ERBB2
3
Show member pathways
11.93 PIK3CA PDCD1 ICOSLG CD8A CD274
4 11.42 TP53 ESR1 CDKN2A
5 11.34 TP53 PIK3CA ERBB2
6
Show member pathways
11.2 TP53 PIK3CA PDCD1 CDKN2A CD8A
7 11.12 TP53 PIK3CA ERBB2 CDKN2A
8 11.1 TP53 ERBB2 CDKN2A
9 10.79 PDCD1 CD8A CD274
10 10.59 ESR1 ERBB2

GO Terms for Endocervical Carcinoma

Biological processes related to Endocervical Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of immature T cell proliferation in thymus GO:0033088 9.13 ERBB2 CDKN2A
2 positive regulation of RNA polymerase II transcription preinitiation complex assembly GO:0045899 8.92 TP53 ESR1

Sources for Endocervical Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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