MCID: END016
MIFTS: 31

Endocervicitis

Categories: Reproductive diseases

Aliases & Classifications for Endocervicitis

MalaCards integrated aliases for Endocervicitis:

Name: Endocervicitis 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5757
NCIt 50 C26762
SNOMED-CT 67 155980007
UMLS 70 C0014127

Summaries for Endocervicitis

Disease Ontology : 12 A cervicitis that is located in the endocervix.

MalaCards based summary : Endocervicitis is related to cervicitis and chlamydia. An important gene associated with Endocervicitis is SELPLG (Selectin P Ligand), and among its related pathways/superpathways are PAK Pathway and CCR5 Pathway in Macrophages. The drugs Mineral oil and Benzoic acid have been mentioned in the context of this disorder. Affiliated tissues include endocervix, cervix and lymph node, and related phenotype is Reduced mammosphere formation.

Related Diseases for Endocervicitis

Graphical network of the top 20 diseases related to Endocervicitis:



Diseases related to Endocervicitis

Symptoms & Phenotypes for Endocervicitis

GenomeRNAi Phenotypes related to Endocervicitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 8.92 HSPD1 PLA2G1B RPS3A SELPLG

Drugs & Therapeutics for Endocervicitis

Drugs for Endocervicitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mineral oil Approved, Vet_approved Phase 4 8042-47-5
2
Benzoic acid Approved, Investigational Phase 4 65-85-0 243
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Prilocaine Approved Phase 4 721-50-6 4906
5
Ethylene Phase 4 74-85-1 6325
6 Sodium Channel Blockers Phase 4
7 Anesthetics Phase 4
8 Anti-Arrhythmia Agents Phase 4
9 Diuretics, Potassium Sparing Phase 4
10 Anesthetics, Local Phase 4
11 Lidocaine, Prilocaine Drug Combination Phase 4
12
acetic acid Approved Phase 3 64-19-7 176
13
Levoleucovorin Approved, Investigational Phase 3 68538-85-2 149436
14
Dinoprostone Approved Phase 3 363-24-6 5280360
15
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
16 Folate Phase 3
17 Vitamin B Complex Phase 3
18 Vitamin B9 Phase 3
19 Fluorodeoxyglucose F18 Phase 1, Phase 2
20 Radiopharmaceuticals Phase 1, Phase 2
21
Ethanol Approved 64-17-5 702
22
Iodine Approved, Investigational 7553-56-2 807
23
Formaldehyde Approved, Vet_approved 50-00-0 712
24
Cadexomer iodine Experimental 94820-09-4
25
Fenbendazole Vet_approved 43210-67-9 3334
26
Retinol acetate 127-47-9 10245972
27 Anti-Bacterial Agents
28 Antibiotics, Antitubercular
29 Hemostatics
30 Pharmaceutical Solutions
31 Anti-Infective Agents, Local

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 Lidocaine-Prilocaine (EMLA) Cream as Analgesia in Hysterosalpingography Practice: a Prospective Randomized Double Blind, Placebo-controlled Clinical Trial Unknown status NCT01303614 Phase 4 Lidocaine-Prilocaine cream;placebo
2 The Value of Endocervical and Endometrial Lidocaine Flushing Before Office Hystroscopy Unknown status NCT03530488 Phase 4 Lidocaine
3 Lidocaine-Prilocaine (EMLA) Cream as Analgesia in Hysteroscopy Practice: a Prospective Randomized Clinical Trial Completed NCT01094015 Phase 4 lidocaine-prilocaine cream
4 Endocervical Lidocaine Spray for Pain Control During Office Hysteroscopy - a Randomized Control Trial. Unknown status NCT03382743 Phase 2, Phase 3 Endocervical Lidocaine spray
5 The Study of Folate Receptor-Mediated Staining Solution (FRD™) In Cervical Unknown status NCT03366493 Phase 3
6 A Randomised Controlled Trial of a Synthetic Osmotic Cervical Dilator for Induction of Labour in Comparison to Dinoprostone Vaginal insErt: the SOLVE Trial Recruiting NCT03001661 Phase 3 Dinoprostone
7 Utility of Preoperative FDG-PET/CT Scanning Prior to Primary Chemoradiation Therapy to Detect Retroperitoneal Lymph Node Metastasis in Patients With Locoregionally Advanced Carcinoma of the Cervix (IB2, IIA ≥ 4 CM, IIB-IVA) or Endometrium (Grade 3 Endometrioid Endometrial Carcinoma; Serous Papillary Carcinoma, Clear Cell Carcinoma, or Carcinosarcoma (Any Grade); and Grade 1 OR 2 Endometrioid Endometrial Carcinoma With Cervical Stromal Involvement Overt in Clinical Examination or Confirmed by Endocervical Curettage Completed NCT00416455 Phase 1, Phase 2 ferumoxtran-10
8 Compare Prostaglandin E2 Against to Combined Use of Transcervical Foley Catheter Balloon With Vaginal Prostaglandin E2 for Induction of Labor at Term: A Randomized Study Completed NCT02861079 Phase 2 PGE2
9 Office Hysteroscopy Versus Stationary Coloposcopy for Diagnosis of Cervical Lesions in Women With Unhealthy Looking Cervix Unknown status NCT03150745
10 Urinary and Sexual Functions After Subtotal Versus Total Abdominal Hysterectomy Unknown status NCT03087565
11 Randomized Controlled Trial of Cervical Lidocaine for Intrauterine Device Insertion Pain Completed NCT01411995 2% lidocaine gel;Water based lubricant
12 Endocervical Evaluation With the Curette Versus Cytobrush for the Diagnosis of Dysplasia of the Uterine Cervix Completed NCT01435590
13 Prospective Collection of Female First-catch Urine, Vaginal Swab, Cervical, and Endocervical Swab Specimens and Male Urethral Swab and First-catch Urine Specimens for Testing With the PANTHER® System Completed NCT01638637
14 Prospective Collection of Female First-catch Urine, Vaginal Swab, Endocervical Swab, and Cervical Specimens for Testing With the APTIMA Trichomonas Vaginalis Assay Completed NCT01427023
15 Double-Blinded Multicenter Clinical Study Assessing the Equivalence of the InPath Cervical Cell Collector to the Standard Endocervical Brush and Spatula in Patients Seeking Primary Pap Screening or Follow-up Screening Completed NCT00266084
16 Maternal and Perinatal Outcome in Women With History of Premature Labor in Previous Pregnancy and Submitted to Active Search of Genital Infection Completed NCT01375439
17 An Observational, Epidemiological Study on the Prevalence of Human Papillomavirus (HPV) Types in Women in the Kingdom of Bahrain Completed NCT01205412
18 An Observational, Epidemiological Study on the Prevalence of Human Papillomavirus (HPV) Types in Women >= 18 Years of Age, in Egypt Completed NCT01158209
19 Post Colposcopy Management of ASC-US and LSIL Pap Tests (PALS Trial): Pilot Study Completed NCT03466710
20 Clinical Study Validating the Adequacy, Efficacy, and Safety of the e2TM Cervical Cell Collector Compared to Standard Spatula/CytoBrush Technique In Patients With Recent History of Abnormal Pap Test Returning for Colposcopy/Biopsy. Completed NCT00474968
21 chemQbiosciences:Manual Liquid Based Cytology Completed NCT01837303
22 Vaginal Self-sampling for Rapid Turnaround Gonorrhea/Chlamydia Testing in the Emergency Department Recruiting NCT03676816
23 Pregnancy Rates in Women With Normal Uterine Cavity With and Without Cervical Abnormalities Recruiting NCT04536389
24 Comparative Analysis of CA-IX, p16, Proliferative Markers, and Human Papilloma Virus (HPV) in the Diagnosis of Significant Cervical Lesions in Patients With a Cytologic Diagnosis of Atypical Glandular Cells (AGC) Recruiting NCT00892866
25 Randomized Controlled Trial Comparing Routine Colposcopy to HPV Testing to Identify Persistent or Recurrent High Grade Cervical Cancer Precursors Active, not recruiting NCT01051895
26 Endocervical Curettage Performed With a Kevorkian Curette Versus Cytobrush in Patients With ASC-H, LSIL, ASCUS HPV Positive and Non-contributory Colposcopy (ZT3) Smear or Atypical Pap Smear With Positive HPV Test Not yet recruiting NCT04000477
27 Cervical Ripening With Foley Bulb Versus Dilapan-S at Home: a Randomized Trial Not yet recruiting NCT04739683
28 Prospective Collection of Female First-catch Urine, Vaginal Swab,Cervical, and Endocervical Swab Specimens for Testing With the APTIMA Assays Terminated NCT01728103
29 Comparing Specimen Collection Techniques to Screen for Sexually Transmitted Infections in Pregnant Women: A Pilot Study Terminated NCT03877263
30 A Pilot Study of Photoacoustic Endoscopy in Endometrial Cancer Withdrawn NCT01498237 Early Phase 1

Search NIH Clinical Center for Endocervicitis

Genetic Tests for Endocervicitis

Anatomical Context for Endocervicitis

The Foundational Model of Anatomy Ontology organs/tissues related to Endocervicitis:

19
Endocervix

MalaCards organs/tissues related to Endocervicitis:

40
Cervix, Lymph Node, Skin

Publications for Endocervicitis

Articles related to Endocervicitis:

(show top 50) (show all 125)
# Title Authors PMID Year
1
Prevalence of bacterial vaginosis and factors associated among women who have sex with women. 61
30462789 2018
2
[The role of modification of innate immunity in development of premature labore]. 61
30378561 2018
3
The effect of contraceptive methods on reproductive tract infections risk: a cross-sectional study having a sample of 52,481 women. 61
27538571 2016
4
Cervicovaginal bacterial count and failure of metronidazole therapy for bacterial vaginosis. 61
26674316 2016
5
[CHARACTERISTICS OF VAGINAL ECOSYSTEM IN ENDOCERVICITIS CHLAMYDIALIS]. 61
27514125 2016
6
[THE ROLE OF COLPOSCOPY AS A METHOD OF METHODOLOGY FOR EARLY AND RAPID ETIOLOGIC DIAGNOSIS IN THE STUDY OF ENDOCERVICITIS CHLAMYDIALIS.] 61
29790713 2016
7
[The Role of Chlamydia Trachomatis in Pregnant Women with Endocervicitis.] 61
29370498 2016
8
The Neisseria gonorrhoeae Obg protein is an essential ribosome-associated GTPase and a potential drug target. 61
26122105 2015
9
[SOME DIAGNOSTIC ASPECTS OF CHLAMYDIA TRACHOMATIS UROGENITAL INFECTIONS]. 61
27032228 2015
10
[Genitourethral infections caused by D-K serotypes of Chlamydia trachomatis]. 61
25544050 2015
11
Rising trend of antimicrobial resistance among Neisseria gonorrhoeae isolates and the emergence of N. gonorrhoeae isolate with decreased susceptibility to ceftriaxone. 61
25560000 2015
12
[Cytology in patients with chlamydial endocervicitis]. 61
25675615 2014
13
Genital Chlamydia trachomatis: an update. 61
24135174 2013
14
[Prevalence of Chlamydia trachomatis and Neisseria gonorrhoea infections in sexual actives young women at a southern Brazilian city]. 61
22267110 2011
15
Risk factors for reproductive tract infections among married women in rural areas of Anhui Province, China. 61
19748723 2009
16
Clinicomicrobiological profile of women with vaginal discharge. 61
19810384 2009
17
[Multiple antibiotic resistance of associative microflora during urogenital pathology]. 61
19186554 2008
18
Correlation between In vitro susceptibility and treatment outcome with azithromycin in gonorrhoea: a prospective study. 61
18087084 2007
19
Epidemilogical analysis of Neisseria gonorrhoeae isolates by antimicrobial susceptibility testing, auxotyping and serotyping. 61
17901639 2007
20
Simultaneous detection of Neisseria gonorrhoeae and Chlamydia trachomatis by PCR in genitourinary specimens from men and women attending an STD clinic. 61
18338709 2007
21
Antibiotic administration to patients with preterm labor and intact membranes: is there a beneficial effect in patients with endocervical inflammation? 61
16966109 2006
22
[Immunological indices in differential diagnosis of active and inactive chronic endocervicitis]. 61
16941886 2006
23
[The role of chlamydia trachomatis and some other associated microorganisms in endocervicitis]. 61
17168494 2006
24
[Genital bacterial carriage during the last trimester of pregnancy and early-onset neonatal sepsis]. 61
15885539 2005
25
Hysteroscopic diagnosis and treatment of endocervical ossification: a case report. 61
15904621 2005
26
Mast cell profile in uterine cervix. 61
16295462 2004
27
Current problems of perinatal Chlamydia trachomatis infections. 61
14962349 2004
28
[Paraendocervical route for metronidazole administration in complex treatment of chronic Trichomonas endocervicitis]. 61
15285407 2004
29
[Mycoplasmal infection in patients with reactive arthritis and seronegative spondyloarthropaties]. 61
12794368 2003
30
Tubo-ovarian abscess occurring 16 years after supracervical hysterectomy. 61
15022878 2003
31
Prevalence of Chlamydia trachomatis & herpes simplex virus in males with urethritis & females with cervicitis attending STD clinic. 61
12592991 2002
32
The prevalence of human papilloma virus DNA in women with mucopurulent endocervicitis. 61
12013119 2002
33
An unusual transmission of Neisseria meningitidis: neonatal conjunctivitis acquired at delivery from the mother's endocervical infection. 61
11196042 2001
34
[Incidence of genitourinary infection caused by Chlamydia trachomatis in a STD center calculated by direct antigen detection]. 61
11153203 2000
35
[The local immunity of the genital system in pregnant women with a genital infection]. 61
10808585 2000
36
Detecting cervical infection among family planning clients: difficulties at the primary health-care level in Indonesia. 61
10726943 2000
37
Single dose oral azithromycin versus seven day doxycycline in the treatment of non-gonococcal mucopurulent endocervicitis. 61
10870778 2000
38
Monocyte-chemo-attractant-protein-1 (MCP-1)-gene expression in cervical intra-epithelial neoplasias and cervical carcinomas. 61
10360812 1999
39
Screening for Chlamydial infection in women attending STD clinic by polymerase chain reaction, ELISA and cell cytology. 61
10810579 1999
40
Current approach to STD management in women. 61
10075231 1998
41
The risk of inadvertent intrauterine device insertion in women carriers of endocervical Chlamydia trachomatis. 61
9773265 1998
42
Unique cytomegalovirus intracytoplasmic inclusions in ectocervical cells on a cervical/endocervical smear. 61
9484638 1998
43
[Cervical cytology: findings dependent on the bio-collector]. 61
9477646 1997
44
Seroprevalence of cytomegalovirus antibodies in patients attending STD and antenatal clinics. 61
9282506 1997
45
Quantitative image analysis of MIB-1 reactivity in inflammatory, hyperplastic, and neoplastic endocervical lesions. 61
8986527 1997
46
[The combined preparation ligentin in the treatment of inflammatory disease of the urogenital organs]. 61
8645060 1995
47
[The direct immunofluorescence test for the diagnosis of Chlamydia trachomatis in gynecology]. 61
7485791 1995
48
[The enzymatic diagnosis of endocervicitis caused by Chlamydia trachomatis]. 61
8743851 1995
49
[Chlamydia trachomatis as a cause of infection in women]. 61
7869979 1993
50
Treatment of cervical chlamydial infection with amoxicillin/clavulanate potassium. 61
18475327 1993

Variations for Endocervicitis

Expression for Endocervicitis

Search GEO for disease gene expression data for Endocervicitis.

Pathways for Endocervicitis

Pathways related to Endocervicitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.52 PPBP PLA2G1B PF4 CXCL5
2
Show member pathways
11.68 PPBP PLA2G1B PF4 CXCL5
3
Show member pathways
11.47 PPBP PF4 CXCL5

GO Terms for Endocervicitis

Cellular components related to Endocervicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 9.16 PLA2G1B HSPD1
2 extracellular space GO:0005615 9.02 PPBP PLA2G1B PF4 HSPD1 CXCL5
3 platelet alpha granule lumen GO:0031093 8.96 PPBP PF4

Biological processes related to Endocervicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.61 PPBP PF4 CXCL5
2 inflammatory response GO:0006954 9.58 PPBP PF4 CXCL5
3 cellular response to lipopolysaccharide GO:0071222 9.54 PPBP PF4 CXCL5
4 chemotaxis GO:0006935 9.5 PPBP PF4 CXCL5
5 defense response GO:0006952 9.43 PPBP PF4 CXCL5
6 chemokine-mediated signaling pathway GO:0070098 9.33 PPBP PF4 CXCL5
7 neutrophil chemotaxis GO:0030593 9.26 PPBP PLA2G1B PF4 CXCL5
8 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 8.92 PPBP PLA2G1B PF4 CXCL5

Molecular functions related to Endocervicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 PPBP PF4 CXCL5
2 chemokine activity GO:0008009 9.13 PPBP PF4 CXCL5
3 CXCR chemokine receptor binding GO:0045236 8.8 PPBP PF4 CXCL5

Sources for Endocervicitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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