Endocrine Exophthalmos disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Endocrine Exophthalmos

MalaCards integrated aliases for Endocrine Exophthalmos:

Name: Endocrine Exophthalmos ¹¹ ¹⁴ ⁷⁵

Thyroid Associated Opthalmopathies ⁷¹

Endocrine Exopthalmos ⁷¹

Classifications:

MalaCards categories:
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:12359

ICD9CM ³⁴ 376.2

SNOMED-CT ⁶⁸ 53061005

UMLS ⁷¹ C0155264 C0339143

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Summaries for Endocrine Exophthalmos

MalaCards based summary: Endocrine Exophthalmos, also known as thyroid associated opthalmopathies, is related to graves disease 1 and hypothyroidism, congenital, nongoitrous, 2. An important gene associated with Endocrine Exophthalmos is TG (Thyroglobulin), and among its related pathways/superpathways are Pluripotent stem cell differentiation pathway and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The drugs Prednisone and Oxytetracycline have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and eye, and related phenotypes are endocrine/exocrine gland and immune system

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Related Diseases for Endocrine Exophthalmos

Diseases related to Endocrine Exophthalmos via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)

#	Related Disease	Score	Top Affiliating Genes
1	graves disease 1	30.4	TSHR TPO TG
2	hypothyroidism, congenital, nongoitrous, 2	30.3	TSHR TG
3	graves' disease	30.1	TSHR TPO TG
4	hashimoto thyroiditis	29.8	TSHR TPO TG
5	graves ophthalmopathy	29.7	TSHR TG IL6
6	endemic goiter	29.6	TSHR TPO TG
7	myxedema	29.6	TSHR TPO TG
8	hypothyroidism	29.4	TSHR TPO TG BGLAP
9	thyroiditis	29.2	TSHR TPO TG IL6
10	hyperthyroidism	29.0	TSHR TPO TG IL6 BGLAP
11	goiter	28.7	TSHR TPO TG IL6 BGLAP
12	middle ear adenocarcinoma	10.2	TG PDX1
13	neonatal thyrotoxicosis	10.1	TSHR TG
14	spindle epithelial tumor with thymus-like differentiation tumor	10.1	TG CD5
15	struma ovarii	10.1	TSHR TG
16	papillary thymic adenocarcinoma	10.1	TG CD5
17	epithelial malignant thymoma	10.1	TG CD5
18	parathyroid gland disease	10.1	TG BGLAP
19	ectopic thymus	10.1	TG CD5
20	dendritic cell thymoma	10.1	TG CD5
21	hypothyroidism, congenital, nongoitrous, 1	10.1	TSHR TG
22	thyroid hormone resistance, generalized, autosomal dominant	10.1	TSHR TG
23	acute thyroiditis	10.1	TPO TG
24	mechanical strabismus	10.1	TPO TG
25	nonencapsulated sclerosing carcinoma	10.1	TPO TG
26	thyroid cancer, nonmedullary, 2	10.1	TSHR TG
27	goiter, multinodular 1, with or without sertoli-leydig cell tumors	10.1	TPO TG
28	hypothyroidism, congenital, nongoitrous, 4	10.1	TPO TG
29	chronic spontaneous urticaria	10.0	TPO TG
30	hypothyroidism, congenital, nongoitrous, 3	10.0
31	autoimmune gastritis	10.0	TPO TG
32	immunodeficiency 58	10.0	TPO TG
33	adrenal cortical hypofunction	10.0	TPO TG
34	pernicious anemia	10.0	TPO TG
35	hypotropia	10.0	TSHR TPO
36	familial thyroid dyshormonogenesis	10.0	TPO TG
37	hyperthyroxinemia	10.0	TSHR TPO
38	euthyroid sick syndrome	9.9	TG IL6
39	hypoadrenocorticism, familial	9.9	TPO TG
40	osteitis fibrosa	9.9	IL6 BGLAP
41	chronic recurrent multifocal osteomyelitis	9.9	IL6 BGLAP
42	periapical periodontitis	9.9	IL6 BGLAP
43	dental pulp disease	9.9	IL6 BGLAP
44	orbital disease	9.9	TSHR TG CD5
45	kearns-sayre syndrome	9.9
46	excessive tearing	9.9
47	mammary paget's disease	9.9
48	occlusion of gallbladder	9.9	SLC7A11 IL6
49	bacterial sepsis	9.9	LY96 IL6
50	iodine hypothyroidism	9.9	TSHR TPO TG

Graphical network of the top 20 diseases related to Endocrine Exophthalmos:

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Symptoms & Phenotypes for Endocrine Exophthalmos

MGI Mouse Phenotypes related to Endocrine Exophthalmos:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	9.63	BGLAP IL6 PDX1 TG TPO TSHR
2	immune system	MP:0005387	9.61	BGLAP CD5 IL6 LY96 PDX1 SLC7A11
3	hearing/vestibular/ear	MP:0005377	9.56	SLC7A11 TG TPO TSHR
4	hematopoietic system	MP:0005397	9.23	BGLAP CD5 IL6 LY96 SLC7A11 TG

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Drugs & Therapeutics for Endocrine Exophthalmos

Drugs for Endocrine Exophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Prednisone

Approved, Vet_approved

Phase 2, Phase 3

53-03-2

5865

Synonyms:

1,2-Dehydrocortisone

1,4-Pregnadiene-17a,21-diol-3,11,20-trione

1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione

1,4-Pregnadiene-17α,21-diol-3,11,20-trione

17,21-Dihydroxypregna-1,4-diene-3,11,20-trione

Acis brand OF prednisone

Acsis, prednison

Adasone

Ancortone

Apo-prednisone

Apotex brand OF prednisone

Aventis brand OF prednisone

Betapar

Bicortone

Cartancyl

Colisone

Cortan

Cortancyl

Cortidelt

Cotone

Cutason

Dacorten

Dacortin

Decortancyl

Decortin

Decortisyl

Dehydrocortisone

Dekortin

Delcortin

Dellacort

Dellacort A

Delta Cortelan

Delta E

Delta-cortelan

Deltacortene

delta-Cortisone

Deltacortisone

Deltacortone

Delta-cortone

DELTA-DOME

Deltasone

Deltison

Deltisona

Deltisone

Deltra

Diadreson

Di-Adreson

Diba brand OF prednisone

Econosone

Encorton

Encortone

Enkortolon

Enkorton

Fawns and mcallan brand OF prednisone

FERNISONE

Ferring brand OF prednisone

Fiasone

GALENpharma brand OF prednisone

Halsey drug brand OF prednisone

Hexal brand OF prednisone

Hoechst brand OF prednisone

Hostacortin

ICN brand OF prednisone

Incocortyl

In-Sone

Juvason

Kortancyl

Lichtenstein brand OF prednisone

Liquid pred

Lisacort

LODOTRA

Lodotra®|Sterapred®

Me-Korti

Merck brand OF prednisone

Merz brand OF prednisone

Metacortandracin

Meticorten

Mibe brand OF prednisone

Nisona

Nizon

Novoprednisone

NSC-10023

Nurison

Orasone

Origen Prednisone

Panafcort

Panasol

PARACORT

Parmenison

Pehacort

Pharmacia brand OF prednisone

PRD

Precort

Predeltin

PREDN

Predni tablinen

PREDNICEN-M

Prednicorm

Prednicort

Prednicot

Prednidib

Prednilonga

Predniment

Prednison

Prednison acsis

Prednison galen

Prednison hexal

Prednisona

Prednisona [INN-Spanish]

Prednisone

PREDNISONE INTENSOL

PREDNISONE TABLETS

Prednisonum

Prednisonum [INN-Latin]

Prednitone

Prednizon

Prednovister

Presone

Pronison

Pronisone

RAYOS

Rectodelt

Retrocortine

Schering-plough brand OF prednisone

Seatrace brand OF prednisone

SERVISONE

Solvay brand OF prednisone

Sone

Sterapred

Supercortil

Trommsdorff brand OF prednisone

Ultracorten

Ultracortene

Winpred

Wojtab

Zenadrid

2

Oxytetracycline

Approved, Investigational, Vet_approved

Phase 2, Phase 3

79-57-2

54715139 54675779

3

Doxycycline

Approved, Investigational, Vet_approved

Phase 2, Phase 3

564-25-0

54671203

4

Antineoplastic Agents, Hormonal

Phase 2, Phase 3

5

Anti-Bacterial Agents

Phase 2, Phase 3

6

Anti-Infective Agents

Phase 2, Phase 3

7

Antiprotozoal Agents

Phase 2, Phase 3

8

Hormones

Phase 2, Phase 3

9

Antiparasitic Agents

Phase 2, Phase 3

10

Hormone Antagonists

Phase 2, Phase 3

11

Antimalarials

Phase 2, Phase 3

12

glucocorticoids

Phase 2, Phase 3

13

Anti-Inflammatory Agents

Phase 2, Phase 3

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	The Effect of Prednisone Versus Doxycycline in Active, Moderately Severe Graves' Orbitopathy: A Randomized, Multi-center, Double-blind, Parallel-controlled Trial	Unknown status	NCT01809444	Phase 2, Phase 3	Prednisone+placebo of Doxycycline;Doxycycline+placebo of Prednisone

Search NIH Clinical Center for Endocrine Exophthalmos

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Genetic Tests for Endocrine Exophthalmos

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Anatomical Context for Endocrine Exophthalmos

Organs/tissues related to Endocrine Exophthalmos:

MalaCards : Thyroid, Bone, Eye, Pituitary

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Publications for Endocrine Exophthalmos

Articles related to Endocrine Exophthalmos:

(show top 50) (show all 177)

#	Title	Authors	PMID	Year
1	Correction of lid retraction and exophthalmos. ⁶²	Baldeschi L	18453764	2008
2	[Screening for endocrine exophthalmos-associated genes/cDNA fragments]. ⁶²	Zheng J...Gong R	16706372	2006
3	Surgical treatment of endocrine exophthalmos by removal of orbital fat: clinical experience. ⁶²	Ferreira MC...Alves CA	12436178	2002
4	Graves' disease of the orbit. ⁶²	Weber AL...Sabates NR	8919134	1996
5	[Endocrine exophthalmos]. ⁶²	Apostol S...Carstocea B	8714104	1996
6	[The treatment of residual exophthalmos by resection of the orbital fat]. ⁶²	Ferreira MC...Alves CA	1340614	1992
7	Decompression of the orbit using a lateral rhinotomy approach in patients with malignant endocrine exophthalmos. ⁶²	Petruson B...Frisen L	2350895	1990
8	Optic nerve involvement in endocrine exophthalmos. ⁶²	Haddad HM	2079900	1990
9	Eye muscle antibodies in endocrine exophthalmos. Clinical and serological observations. ⁶²	Kahaly G...Pfeiffer EF	2744719	1989
10	[Personal experience in the study of thyroid autoimmunity and endocrine exophthalmos]. ⁶²	Winand R	2575920	1989
11	[The role of episcleral venous pressure in the development of secondary glaucomas]. ⁶²	Jorgensen JS...Guthoff R	3210642	1988
12	[The treatment of endocrine exophthalmos]. ⁶²	Winand R...Mahieu P	3399762	1988
13	[Surgery of the orbit in endocrine exophthalmos. Preliminary results of a new approach to orbital decompression in Basedow orbital diseases]. ⁶²	Koornneef L	3268304	1988
14	[The use of botulinum toxin in endocrine exophthalmos]. ⁶²	Roggenkamper P	3273259	1988
15	[The medical treatment of endocrine exophthalmos]. ⁶²	Glinoer D	3268307	1988
16	Endocrine exophthalmos conservative management. ⁶²	Haddad HM	3508403	1987
17	Enhanced prednisolone elimination: a possible cause for failure of glucocorticoid therapy in Graves' ophthalmopathy. ⁶²	Legler UF	3583222	1987
18	[Importance of the assay of T3 and T4 tears and plasma for the diagnosis of endocrine exophthalmos]. ⁶²	Glomaud J...Liotet S	3448120	1987
19	[Glaucoma in endocrine exophthalmus]. ⁶²	Buschmann W	3754914	1986
20	Autoimmune thyroid disease. ⁶²	Bottazzo GF...Doniach D	2871804	1986
21	[Operative therapy of severe endocrine exophthalmos]. ⁶²	Buschmann W...Richter W	3754842	1986
22	Transantral orbital decompression in the treatment of Graves' disease. ⁶²	Grahne B...Tommila V	3840193	1985
23	Orbital decompression in endocrine exophthalmos of Graves' disease. ⁶²	Lamberg BA...Valimaki M	3839618	1985
24	T-lymphocyte-subsets in endocrine exophthalmos. ⁶²	Cenmamo G...Castello G	3879963	1985
25	Surgical treatment for malignant exophthalmos of endocrine origin. ⁶²	Hanabury MR...Chandler AC	6472017	1984
26	[Ethmoidectomy and orbital decompression in endocrine ophthalmopathy]. ⁶²	Richter WC...Buschmann W	6548280	1984
27	[Ophthalmo-rhinosurgical decompression operation in malignant endocrine exophthalmus]. ⁶²	Buschmann W...Richter W	6548269	1984
28	[Malignant endocrine exophthalmos. Therapeutic problems]. ⁶²	Arnaud B...Esmenjaud E	6549503	1984
29	Management of inadequate transantral orbital decompression with extended lateral orbitotomy. ⁶²	Hurwitz J...Rosenstock T	6688372	1983
30	[Surgical treatment of malignant endocrine exophthalmos]. ⁶²	Busse H...Muller RP	6865258	1983
31	D-scan ultrasonography of orbital lesion. ⁶²	Ito N...Minei M	6855013	1983
32	[Myxedema tuberosum atypicum (Jadassohn-Doesserkker, 1916) in the clinical picture of the myxodermias and in the normal course of Graves-Basedow's disease]. ⁶²	Rabello FE...Cordeiro JG	6366397	1983
33	Autoimmune endocrine exophthalmos. ⁶²		6129469	1982
34	[Endocrine exophthalmos and autoimmune thyroiditis]. ⁶²	Francois JH...Rateau J	6897375	1982
35	Tests of thyroid function important to the ophthalmologist. ⁶²	Hurwitz JJ	6809298	1982
36	Computerized tomography in endocrine exophthalmos: report of a case. ⁶²	Solomon A...Greenwald M	6896413	1982
37	The effect of anterior orbital decompression on motility in thyroid exophthalmos. ⁶²	Dixon R...Lesser GR	7335293	1981
38	Plasma exchange in conjunction with immunosuppressive drug therapy in the treatment of endocrine exophthalmos. ⁶²	Sawers JS...Donaldson AA	6896074	1981
39	[Endocrine exophthalmos]. ⁶²	Gilboa Y...Brauman A	6895880	1981
40	[Value of the scanner in the evaluation of endocrine exophthalmos]. ⁶²	Brasseur G...Langlois J	6895611	1981
41	Endocrine exophthalmos. ⁶²	Nathan MD...Porubsky ES	6894358	1981
42	Serum thyroglobulin, its autoantibody and thyroid stimulating antibodies in the endocrine exophthalmos. ⁶²	Feldt-Rasmussen U...Date J	6894054	1981
43	Endocrine exophthalmos or orbital pseudotumour. ⁶²	Jellinek EH	6110019	1981
44	Endocrine exophthalmos or orbital pseudotumour. ⁶²	Feek CM...Toft AD	6109880	1981
45	[Endocrine exophthalmos. New nosological proposal and current therapeutic trends]. ⁶²	Maiello M	7006014	1980
46	Transantral orbital decompression for endocrine exophthalmos--an appraisal. ⁶²	Shaw HJ	6893600	1980
47	Endocrine exophthalmos; conservative management. ⁶²	Haddad HM	6938804	1980
48	Progress in endocrine exophthalmos. ⁶²	Havard CW	582020	1979
49	[Hyperthyroidism: diagnosis (author's transl)]. ⁶²	Horster FA	104101	1978
50	Ultrasonography and computer tomography in orbital diagnosis. With special reference to dysthyroid ophthalmopathy. ⁶²	Fledelius HC...Glydensted C	211790	1978

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Genes for Endocrine Exophthalmos

Genes related to Endocrine Exophthalmos (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TG	Thyroglobulin	Protein Coding	5.57	DISEASES inferred ¹⁴
2	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	4.34	DISEASES inferred ¹⁴
3	PDX1	Pancreatic And Duodenal Homeobox 1	Protein Coding	3.94	DISEASES inferred ¹⁴
4	LY96	Lymphocyte Antigen 96	Protein Coding	3.67	DISEASES inferred ¹⁴
5	TSHR	Thyroid Stimulating Hormone Receptor	Protein Coding	3.66	DISEASES inferred ¹⁴
6	SLC7A11	Solute Carrier Family 7 Member 11	Protein Coding	3.53	DISEASES inferred ¹⁴
7	TPO	Thyroid Peroxidase	Protein Coding	3.45	DISEASES inferred ¹⁴
8	IL6	Interleukin 6	Protein Coding	3.14	DISEASES inferred ¹⁴
9	CD5	CD5 Molecule	Protein Coding	2.9	DISEASES inferred ¹⁴

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Variations for Endocrine Exophthalmos

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Expression for Endocrine Exophthalmos

Search GEO for disease gene expression data for Endocrine Exophthalmos.

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Pathways for Endocrine Exophthalmos

Pathways related to Endocrine Exophthalmos according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Pluripotent stem cell differentiation pathway ⁷⁴	11.05	TPO IL6
2	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	10.97	IL6 BGLAP
3	Fibrin complement receptor 3 signaling pathway ⁷⁴	10.89	LY96 IL6
4	Validated transcriptional targets of AP1 family members Fra1 and Fra2 ⁶¹	10.7	IL6 BGLAP
5	Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway ⁷⁴	10.43	SLC7A11 IL6
6	Thyroxine (thyroid hormone) production ⁷⁴	10.1	TSHR TPO TG

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GO Terms for Endocrine Exophthalmos

Biological processes related to Endocrine Exophthalmos according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	thyroid hormone generation	GO:0006590	9.56	TPO TG
2	endocrine pancreas development	GO:0031018	9.5	PDX1 IL6
3	hormone biosynthetic process	GO:0042446	9.46	TPO TG
4	response to organic cyclic compound	GO:0014070	9.26	SLC7A11 PDX1 BGLAP
5	response to glucocorticoid	GO:0051384	9.1	PDX1 IL6 BGLAP

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Sources for Endocrine Exophthalmos

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: END034 MIFTS: 32	Endocrine Exophthalmos Categories: Bone diseases	Data Licensing For inquiries, contact: [email protected]
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