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MCID: END034
MIFTS: 27

Endocrine Exophthalmos

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Endocrine Exophthalmos

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MalaCards integrated aliases for Endocrine Exophthalmos:

Name: Endocrine Exophthalmos 12 15
Thyroid Associated Opthalmopathies 72
Endocrine Exopthalmos 72

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12359
ICD9CM 35 376.2
SNOMED-CT 68 53061005
UMLS 72 C0155264 C0339143
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Summaries for Endocrine Exophthalmos

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MalaCards based summary : Endocrine Exophthalmos, also known as thyroid associated opthalmopathies, is related to hypothyroidism and autoimmune disease. An important gene associated with Endocrine Exophthalmos is TG (Thyroglobulin), and among its related pathways/superpathways is Aldosterone synthesis and secretion. The drugs Oxytetracycline and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include thyroid, eye and testes, and related phenotypes are Dynamic nuclei (hole, folded or small irregular) and endocrine/exocrine gland

Wikipedia : 75 Graves ophthalmopathy,also known as thyroid eye disease (TED), is an autoimmune inflammatory disorder of... more...

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Related Diseases for Endocrine Exophthalmos

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Diseases related to Endocrine Exophthalmos via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 hypothyroidism 29.1 TG POMC
2 autoimmune disease 28.9 TG CD40LG
3 exophthalmos 11.0
4 graves' disease 10.2
5 graves disease 1 10.1
6 hashimoto thyroiditis 10.0
7 thyroiditis 10.0
8 hyperthyroidism 10.0
9 myxedema 9.9
10 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
11 intraocular pressure quantitative trait locus 9.9
12 goiter 9.9
13 endemic goiter 9.9
14 mammary paget's disease 9.9
15 orbital disease 9.9
16 acute thyroiditis 9.6 TG POMC
17 hypoadrenalism 9.6 TG POMC
18 thyroid crisis 9.6 TG POMC
19 hypothyroidism, congenital, nongoitrous, 4 9.5 TG POMC
20 thyroid gland disease 9.5 TG POMC
21 cell type benign neoplasm 9.4 TG POMC
22 thyroid carcinoma, familial medullary 9.4 TG POMC
23 thyroid cancer, nonmedullary, 2 9.3 TG POMC

Graphical network of the top 20 diseases related to Endocrine Exophthalmos:



Diseases related to Endocrine Exophthalmos
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Symptoms & Phenotypes for Endocrine Exophthalmos

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GenomeRNAi Phenotypes related to Endocrine Exophthalmos according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Dynamic nuclei (hole, folded or small irregular) GR00257-A-1 8.8 CD40LG POMC TG

MGI Mouse Phenotypes related to Endocrine Exophthalmos:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 8.8 CD40LG POMC TG
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Drugs & Therapeutics for Endocrine Exophthalmos

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Drugs for Endocrine Exophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxytetracycline Approved, Investigational, Vet_approved Phase 2, Phase 3 79-57-2 5280972 54715139
2
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
3
Doxycycline Approved, Investigational, Vet_approved Phase 2, Phase 3 564-25-0 54671203
4 Anti-Inflammatory Agents Phase 2, Phase 3
5 glucocorticoids Phase 2, Phase 3
6 Hormones Phase 2, Phase 3
7 Anti-Infective Agents Phase 2, Phase 3
8 Anti-Bacterial Agents Phase 2, Phase 3
9 Antineoplastic Agents, Hormonal Phase 2, Phase 3
10 Hormone Antagonists Phase 2, Phase 3
11 Antimalarials Phase 2, Phase 3
12 Antiprotozoal Agents Phase 2, Phase 3
13 Antiparasitic Agents Phase 2, Phase 3
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect of Prednisone Versus Doxycycline in Active, Moderately Severe Graves' Orbitopathy: A Randomized, Multi-center, Double-blind, Parallel-controlled Trial Unknown status NCT01809444 Phase 2, Phase 3 Prednisone+placebo of Doxycycline;Doxycycline+placebo of Prednisone

Search NIH Clinical Center for Endocrine Exophthalmos

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Genetic Tests for Endocrine Exophthalmos

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Anatomical Context for Endocrine Exophthalmos

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MalaCards organs/tissues related to Endocrine Exophthalmos:

41
Thyroid, Eye, Testes, Pituitary
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Publications for Endocrine Exophthalmos

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Articles related to Endocrine Exophthalmos:

(show top 50) (show all 177)
# Title Authors PMID Year
1
Correction of lid retraction and exophthalmos. 38
18453764 2008
2
[Screening for endocrine exophthalmos-associated genes/cDNA fragments]. 38
16706372 2006
3
Surgical treatment of endocrine exophthalmos by removal of orbital fat: clinical experience. 38
12436178 2002
4
Graves' disease of the orbit. 38
8919134 1996
5
[Endocrine exophthalmos]. 38
8714104 1996
6
[The treatment of residual exophthalmos by resection of the orbital fat]. 38
1340614 1992
7
Decompression of the orbit using a lateral rhinotomy approach in patients with malignant endocrine exophthalmos. 38
2350895 1990
8
Optic nerve involvement in endocrine exophthalmos. 38
2079900 1990
9
Eye muscle antibodies in endocrine exophthalmos. Clinical and serological observations. 38
2744719 1989
10
[Personal experience in the study of thyroid autoimmunity and endocrine exophthalmos]. 38
2575920 1989
11
[The role of episcleral venous pressure in the development of secondary glaucomas]. 38
3210642 1988
12
[The treatment of endocrine exophthalmos]. 38
3399762 1988
13
[The use of botulinum toxin in endocrine exophthalmos]. 38
3273259 1988
14
[The medical treatment of endocrine exophthalmos]. 38
3268307 1988
15
[Surgery of the orbit in endocrine exophthalmos. Preliminary results of a new approach to orbital decompression in Basedow orbital diseases]. 38
3268304 1988
16
Endocrine exophthalmos conservative management. 38
3508403 1987
17
Enhanced prednisolone elimination: a possible cause for failure of glucocorticoid therapy in Graves' ophthalmopathy. 38
3583222 1987
18
[Importance of the assay of T3 and T4 tears and plasma for the diagnosis of endocrine exophthalmos]. 38
3448120 1987
19
[Glaucoma in endocrine exophthalmus]. 38
3754914 1986
20
Autoimmune thyroid disease. 38
2871804 1986
21
[Operative therapy of severe endocrine exophthalmos]. 38
3754842 1986
22
Transantral orbital decompression in the treatment of Graves' disease. 38
3840193 1985
23
Orbital decompression in endocrine exophthalmos of Graves' disease. 38
3839618 1985
24
T-lymphocyte-subsets in endocrine exophthalmos. 38
3879963 1985
25
Surgical treatment for malignant exophthalmos of endocrine origin. 38
6472017 1984
26
[Ophthalmo-rhinosurgical decompression operation in malignant endocrine exophthalmus]. 38
6548269 1984
27
[Ethmoidectomy and orbital decompression in endocrine ophthalmopathy]. 38
6548280 1984
28
[Malignant endocrine exophthalmos. Therapeutic problems]. 38
6549503 1984
29
Management of inadequate transantral orbital decompression with extended lateral orbitotomy. 38
6688372 1983
30
[Surgical treatment of malignant endocrine exophthalmos]. 38
6865258 1983
31
[Myxedema tuberosum atypicum (Jadassohn-Doesserkker, 1916) in the clinical picture of the myxodermias and in the normal course of Graves-Basedow's disease]. 38
6366397 1983
32
D-scan ultrasonography of orbital lesion. 38
6855013 1983
33
Autoimmune endocrine exophthalmos. 38
6129469 1982
34
[Endocrine exophthalmos and autoimmune thyroiditis]. 38
6897375 1982
35
Tests of thyroid function important to the ophthalmologist. 38
6809298 1982
36
Computerized tomography in endocrine exophthalmos: report of a case. 38
6896413 1982
37
The effect of anterior orbital decompression on motility in thyroid exophthalmos. 38
7335293 1981
38
Plasma exchange in conjunction with immunosuppressive drug therapy in the treatment of endocrine exophthalmos. 38
6896074 1981
39
[Endocrine exophthalmos]. 38
6895880 1981
40
[Value of the scanner in the evaluation of endocrine exophthalmos]. 38
6895611 1981
41
Endocrine exophthalmos. 38
6894358 1981
42
Endocrine exophthalmos or orbital pseudotumour. 38
6110019 1981
43
Serum thyroglobulin, its autoantibody and thyroid stimulating antibodies in the endocrine exophthalmos. 38
6894054 1981
44
Endocrine exophthalmos or orbital pseudotumour. 38
6109880 1981
45
[Endocrine exophthalmos. New nosological proposal and current therapeutic trends]. 38
7006014 1980
46
Transantral orbital decompression for endocrine exophthalmos--an appraisal. 38
6893600 1980
47
Endocrine exophthalmos; conservative management. 38
6938804 1980
48
Progress in endocrine exophthalmos. 38
582020 1979
49
[Hyperthyroidism: diagnosis (author's transl)]. 38
104101 1978
50
Ultrasonography and computer tomography in orbital diagnosis. With special reference to dysthyroid ophthalmopathy. 38
211790 1978
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Variations for Endocrine Exophthalmos

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Expression for Endocrine Exophthalmos

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Search GEO for disease gene expression data for Endocrine Exophthalmos.
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Pathways for Endocrine Exophthalmos

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Pathways related to Endocrine Exophthalmos according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Aldosterone synthesis and secretion 37
Show member pathways
 11.39 TG POMC
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GO Terms for Endocrine Exophthalmos

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Cellular components related to Endocrine Exophthalmos according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 8.8 TG POMC CD40LG

Molecular functions related to Endocrine Exophthalmos according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 TG POMC
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Sources for Endocrine Exophthalmos

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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