Endocrine Exophthalmos disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: END034 MIFTS: 31	Endocrine Exophthalmos Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Endocrine Exophthalmos

MalaCards integrated aliases for Endocrine Exophthalmos:

Name: Endocrine Exophthalmos ¹² ¹⁵

Thyroid Associated Opthalmopathies ⁷¹

Endocrine Exopthalmos ⁷¹

Classifications:

MalaCards categories:
Anatomical: Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:12359

ICD9CM ³⁴ 376.2

SNOMED-CT ⁶⁷ 53061005

UMLS ⁷¹ C0155264 C0339143

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Summaries for Endocrine Exophthalmos

MalaCards based summary : Endocrine Exophthalmos, also known as thyroid associated opthalmopathies, is related to graves disease 1 and orbital disease. An important gene associated with Endocrine Exophthalmos is TG (Thyroglobulin), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. The drugs Prednisone and Oxytetracycline have been mentioned in the context of this disorder. Affiliated tissues include thyroid, eye and lung, and related phenotypes are Dynamic nuclei (hole, folded or small irregular) and integument

Wikipedia : ⁷⁴ Graves ophthalmopathy,also known as thyroid eye disease (TED), is an autoimmune inflammatory disorder of... more...

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Related Diseases for Endocrine Exophthalmos

Diseases related to Endocrine Exophthalmos via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)

#	Related Disease	Score	Top Affiliating Genes
1	graves disease 1	30.5	TG POMC KCNJ18
2	orbital disease	30.3	TG CD40LG
3	hyperthyroidism	30.3	TG POMC KCNJ18
4	myxedema	30.3	TG POMC
5	exophthalmos	11.0
6	acute thyroiditis	10.4	TG POMC
7	hypoadrenalism	10.4	TG POMC
8	ovarian serous adenofibroma	10.4	TG POMC
9	mechanical strabismus	10.4	TG CD40LG
10	adrenal cortical hypofunction	10.3	TG POMC
11	trichinosis	10.3	POMC CD40LG
12	nasal cavity olfactory neuroblastoma	10.3	TG MME
13	uveoparotid fever	10.2	POMC CD40LG
14	hairy tongue	10.2	POMC CD40LG
15	cranial nerve palsy	10.2	POMC CD40LG
16	hyperglobulinemic purpura	10.2	CD40LG BRD4
17	spindle epithelial tumor with thymus-like differentiation tumor	10.2	TG CD5
18	papillary thymic adenocarcinoma	10.2	TG CD5
19	epithelial malignant thymoma	10.2	TG CD5
20	graves' disease	10.2
21	ectopic thymus	10.2	TG CD5
22	hilar lung carcinoma	10.2	MME CD40LG
23	lung hilum cancer	10.2	MME CD40LG
24	anal spasm	10.2	POMC APOLD1
25	cryoglobulinemia, familial mixed	10.1	CD5 CD40LG
26	waldenstroem's macroglobulinemia	10.1	CD5 CD40LG
27	splenic infarction	10.1	CD5 CD40LG
28	fallopian tube endometrioid adenocarcinoma	10.1	MME APOLD1
29	exophthalmic ophthalmoplegia	10.1	POMC KCNJ18 BRD4
30	alpha chain disease	10.0	CD5 CD40LG
31	hashimoto thyroiditis	10.0
32	thyroiditis	10.0
33	bladder lymphoma	10.0	MME CD5
34	prostate lymphoma	10.0	MME CD5
35	epiglottis neoplasm	10.0	MME CD5
36	liver lymphoma	10.0	MME CD5
37	bone lymphoma	10.0	MME CD5
38	colon lymphoma	10.0	MME CD5
39	intravascular large b-cell lymphoma	10.0	MME CD5
40	lung lymphoma	10.0	MME CD5
41	breast lymphoma	10.0	MME CD5
42	thyroid gland medullary carcinoma	10.0	TG POMC
43	sclerosing hepatic carcinoma	10.0	MME CD5
44	gastrointestinal lymphoma	10.0	MME CD5
45	composite lymphoma	10.0	MME CD5
46	adult lymphoma	10.0	MME CD5
47	tracheal lymphoma	10.0	MME CD5
48	acute adrenal insufficiency	10.0	POMC IL6
49	spinal cord lymphoma	10.0	MME CD5
50	breast osteosarcoma	10.0	MME CD5

Graphical network of the top 20 diseases related to Endocrine Exophthalmos:

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Symptoms & Phenotypes for Endocrine Exophthalmos

GenomeRNAi Phenotypes related to Endocrine Exophthalmos according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Dynamic nuclei (hole, folded or small irregular)	GR00257-A-1	9.17	BRD4 CD40LG CD5 POMC SHANK2 SLC7A11

MGI Mouse Phenotypes related to Endocrine Exophthalmos:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument	MP:0010771	9.5	CD40LG CD5 IL6 MME POMC SLC7A11
2	nervous system	MP:0003631	9.23	CD40LG CD5 IL6 MME POMC SHANK2

Sources

Drugs & Therapeutics for Endocrine Exophthalmos

Drugs for Endocrine Exophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Prednisone

Approved, Vet_approved

Phase 2, Phase 3

53-03-2

5865

Synonyms:

(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione

(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione

(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione

.delta. E

.delta.(sup1)-Cortisone

.delta.1-Cortisone

.delta.1-Dehydrocortisone

.delta.-Cortelan

.delta.-Cortisone

.delta.-Cortone

.delta.-E

.delta.sone

1,2-Dehydrocortisone

1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione

1,4-Pregnadiene-17a,21-diol-3,11,20-trione

1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione

1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione

1,4-Pregnadiene-17α,21-diol-3,11,20-trione

17,21-Dihydroxypregna-1,4-diene-3,11,20-trione

17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione

1-Cortisone

1-Dehydrocortisone

53-03-2

68-59-7

81552_FLUKA

AC-11112

AC1L1LB2

AC1Q29EZ

Acis brand OF prednisone

ACon0_000082

ACon1_000297

Adasone

AI3-52939

Ancortone

apo-Prednisone

Apo-prednisone

Apo-Prednisone

Apotex brand OF prednisone

Aventis brand OF prednisone

Betapar

Bicortone

Bio-0649

BPBio1_000323

BRD-K85883481-001-04-2

BSPBio_000293

C07370

C21H26O5

Cartancyl

CCRIS 2646

CHEBI:8382

CHEMBL635

CID5865

Colisone

Cortan

Cortancyl

Cortidelt

Cotone

CPD001227202

Cutason

Dacorten

Dacortin

DB00635

Decortancyl

Decortin

Decortisyl

Dehydrocortisone

Dekortin

Delcortin

Dellacort

Dellacort A

delta cortelan

Delta Cortelan

Delta E

Delta E.

delta(sup 1)-Cortisone

delta(sup 1)-Dehydrocortisone

delta-1-Cortisone

delta-1-Dehydrocortisone

Delta-cortelan

Delta-Cortelan

Deltacortene

delta-Cortisone

Deltacortisone

Delta-cortisone

delta-Cortone

Deltacortone

Delta-cortone

Delta-dome

Delta-Dome

Deltasone

Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone

Deltison

Deltisona

Deltisone

Deltra

Diadreson

Di-Adreson

Diba brand OF prednisone

Econosone

EINECS 200-160-3

Encorton

Encortone

Enkortolon

Enkorton

Fawns and mcallan brand OF prednisone

Fernisone

Ferring brand OF prednisone

Fiasone

GALENpharma brand OF prednisone

Halsey drug brand OF prednisone

Hexal brand OF prednisone

HMS1568O15

HMS2090J13

Hoechst brand OF prednisone

Hostacortin

HSDB 3168

ICN brand OF prednisone

Incocortyl

In-Sone

Juvason

Kortancyl

Lichtenstein brand OF prednisone

Liquid pred

Liquid Pred

Lisacort

LMST02030180

Lodotra

LS-1325

MEGxm0_000443

Me-Korti

Merck brand OF prednisone

Merz brand OF prednisone

Metacortandracin

Meticorten

Meticorten (Veterinary)

Metrevet (Veterinary)

Mibe brand OF prednisone

MLS001061265

MLS001304073

MLS001335907

MLS001335908

MLS002154191

MLS002207083

MolPort-001-740-041

NCGC00090766-01

NCGC00090766-02

NCGC00090766-03

NCI60_000008

NCI-C04897

Nisona

Nizon

Novoprednisone

NSC 10023

NSC10023

Nurison

Orasone

Origen Prednisone

P1276

P6254_SIGMA

Panafcort

Panasol

Paracort

Parmenison

Pehacort

Pharmacia brand OF prednisone

PRD

Precort

Predeltin

Predni tablinen

Prednicen-M

Prednicorm

Prednicort

Prednicot

Prednidib

Prednilonga

Predniment

Prednison

Prednison acsis

Prednison galen

Prednison hexal

Prednisona

Prednisona [INN-Spanish]

Prednisone

Prednisone [INN:BAN]

Prednisone Intensol

Prednisonum

Prednisonum [INN-Latin]

Prednitone

Prednizon

Prednovister

Presone

Prestwick_405

Prestwick0_000077

Prestwick1_000077

Prestwick2_000077

Prestwick3_000077

Pronison

Pronisone

Rectodelt

Retrocortine

S1622_Selleck

SAM002264641

Schering-plough brand OF prednisone

Seatrace brand OF prednisone

Servisone

SK-Prednisone

SMR000718760

SMR001227202

Solvay brand OF prednisone

Sone

SPBio_002214

Sterapred

Supercortil

Trommsdorff brand OF prednisone

U 6020

Ultracorten

Ultracortene

UNII-VB0R961HZT

Winpred

WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ

Wojtab

Zenadrid

Zenadrid (veterinary)

Zenadrid [veterinary]

ZINC03875357

Oxytetracycline

Approved, Investigational, Vet_approved

Phase 2, Phase 3

79-57-2

5280972 54715139

Synonyms:

(2E,4S,4aR,5S,5aR,6S,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione

(2E,4S,6S,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione

(2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione

(2Z,4S,4aR,5S,5aR,6S,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione

(4S,4aR,5S,5aR,6S,12aS)-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

102287-29-6

103351-03-7

105145-10-6

106216-57-3

1405-95-4

15251-48-6

2058-46-0 (mono-hydrochloride)

2058-46-0 (mono-Hydrochloride)

21645-09-0

4-14-00-02633 (Beilstein Handbook Reference)

52214-46-7

5-Hydroxytetracycline

5-Hydroxy-tetracycline

6153-64-6 (di-hydrate)

6153-64-6 (Di-hydrate)

6153-65-7 (di-hydrochloride salt, di-hydrate)

6153-65-7 (Di-hydrochloride salt, di-hydrate)

64038-91-1 (sulfate (2:1))

69766-62-7 (hydrochloride salt)

7179-50-2 (calcium (1:1) salt)

7179-50-2 (Calcium (1:1) salt)

79-57-2

79-57-2 (ANHYDROUS)

856305-69-6

96310-42-8

Abbocin

AC-12777

AC1NQXTY

AC1NQZMP

AC1NS4NE

AC1O52HP

Adamycin

AKOS001632631

Antibiotic TM 25

Berkmycen

Biostat

Biostat pa

Biostat PA

Bisolvomycin

BPBio1_000302

BRN 2714587

BSPBio_000274

BSPBio_002151

C06624

C22H24N2O9

CHEBI:27701

CHEMBL1517

CID5280972

CID5282186

CID5353856

CID6426716

Dabicycline

Dalimycin

DB00595

DivK1c_000225

EINECS 201-212-8

Embryostat

Fanterrin

Galsenomycin

Geomycin

Geomycin (Streptomyces vimosus)

Geotilin

HSDB 3145

Hydroxytetracycline

Hydroxytetracyclinum

IDI1_000225

Imperacin

KBio1_000225

KBio2_001535

KBio2_004103

KBio2_006671

KBio3_001651

KBioGR_000912

KBioSS_001535

LA 200

Lenocycline

Liquamycin

Liquamycin la 200

Liquamycin LA 200

LMPK07000005

LS-93860

Macocyn

Medamycin

Mepatar

MLS000069429

MolPort-002-524-946

MolPort-005-934-326

Mycoshield TMQTHC 20

NCGC00091268-04

NCGC00091268-05

NCI-C56473

NINDS_000225

NSC 9169

NSC-9169

NSC9169 (HCL)

Oksisyklin

Ossitetraciclina

Ossitetraciclina [DCIT]

OTC

OTC (antibiotic)

Oxacycline

Oxitetraciclina

Oxitetraciclina [INN-Spanish]

Oxitetracyclin

Oxitetracycline

Oxitetracyclinum

Oxydon

Oxy-kesso-tetra

Oxymycin

Oxymykoin

Oxypam

Oxysteclin

Oxyterracin

Oxyterracine

Oxyterracyne

Oxytetracid

Oxytetracyclin

oxytetracycline

Oxytetracycline

Oxytétracycline

Oxytetracycline (anhydrous)

Oxytetracycline (internal use)

Oxytetracycline [INN]

Oxytetracycline amphoteric

Oxytetracycline anhydrous

Oxytetracycline calcium

Oxytetracycline HCl

Oxytetracyclinum

Oxytetracyclinum [INN-Latin]

Pennox 200

Prestwick0_000307

Prestwick1_000307

Prestwick2_000307

Prestwick3_000307

Proteroxyna

Riomitsin

Ryomycin

S1773_Selleck

SMR000059000

Solkaciclina

SPBio_001055

SPBio_002493

Spectrum_001055

Spectrum2_000988

Spectrum3_000536

Spectrum4_000466

Spectrum5_001148

Stecsolin

Stevacin

STOCK1N-50853

Tarocyn

Tarosin

Teravit

Terrafungine

Terramitsin

Terramycin

Terramycin im

Terramycin Q50

Terramycin, Liquamycin, Oxytetracycline

Tetran

TM 5

UNII-SLF0D9077S

UNII-X20I9EN955

Unimycin

Ursocyclin

Ursocycline

Vendarcin

Doxycycline

Approved, Investigational, Vet_approved

Phase 2, Phase 3

564-25-0

54671203

Synonyms:

(2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

(2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

(2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

(2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

(4S,4AR,5S,5ar,6R,12as)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

10597-92-9

17086-28-1 (mono-hydrate)

24390-14-5

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)

41411-66-9 (6-epimer, mono-hydrochloride)

564-25-0

5-Hydroxy-a-6-deoxytetracycline

5-Hydroxy-alpha-6-deoxytetracycline

5-hydroxy-α-6-deoxytetracycline

5-Hydroxy-α-6-deoxytetracycline

69935-17-7 (mono-hydrochloride, di-hydrate)

6a-Deoxy-5-oxytetracycline

6alpha-deoxy-5-oxytetracycline

6-alpha-deoxy-5-oxytetracycline

6alpha-Deoxy-5-oxytetracycline

6-alpha-Deoxy-5-oxytetracycline

6-Deoxyoxytetracycline

6-Deoxytetracycline

6α-deoxy-5-oxytetracycline

7164-70-7

7264-10-0

94088-85-4 (calcium salt (1:2))

AB08 (*Fosfatex)

AC1NQXW7

AC1NS4CW

AC1NUYS8

AC1O8PYM

alpha-6-Deoxy-5-hydroxytetracycline

alpha-6-Deoxyoxytetracycline

alpha-Doxycycline

Alti-Doxycycline

Anhydrous doxycycline

Apo-Doxy

Atridox

Azudoxat

BCBcMAP01_000024

BIDD:GT0146

BMY-28689

BPBio1_000951

BSPBio_000863

BSPBio_001936

BU-3839T

C06973

CHEBI:50845

CHEMBL1433

CID5281011

CID5353597

CID5463943

CID6713981

CPD001550033

D07876

DB00254

Deoxymykoin

DivK1c_000345

DMSC (*Fosfatex)

Dossiciclina

Dossiciclina [DCIT]

Doxcycline anhydrous

DOXCYCLINE ANHYDROUS

Doxiciclina

Doxiciclina [INN-Spanish]

Doxiciclina [Italian]

Doxitard

Doxivetin

DOXY

Doxy-Caps

Doxycen

Doxychel

Doxychel (TN)

Doxycin

Doxycyclin

doxycycline

Doxycycline

Doxycycline (200mg/day) or Placebo

Doxycycline (anhydrous)

Doxycycline (INN)

Doxycycline (internal use)

Doxycycline (TN)

Doxycycline anhydrous

DOXYCYCLINE CALCIUM

Doxycycline hyclate

Doxycycline monohydrate

DOXYCYCLINE MONOHYDRATE

Doxycycline-Chinoin

Doxycyclinum

Doxycyclinum [INN-Latin]

Doxy-Puren

Doxysol

Doxy-Tabs

Doxytec

Doxytetracycline

EINECS 209-271-1

GS-3065 (*monohydrate)

HMS2090E06

HSDB 3071

Hydramycin

IDI1_000345

Investin

Jenacyclin

KBio1_000345

KBio2_001287

KBio2_003855

KBio2_006423

KBio3_001156

KBioGR_001133

KBioSS_001287

Liviatin

Lopac0_000405

LS-187766

LS-93868

MolPort-002-507-423

Monodox

Monodox (*monohydrate)

NCGC00161602-01

NCGC00161602-03

NCGC00161602-04

NCGC00167961-01

NCGC00179395-01

NINDS_000345

Novo-Doxylin

NSC633557

Nu-Doxycycline

Oracea

Prestwick0_000852

Prestwick1_000852

Prestwick2_000852

Prestwick3_000852

Ronaxan

SAM002589932

SMP1_000107

Spanor

SPBio_000246

SPBio_002784

Spectrum_000807

Spectrum2_000143

Spectrum3_000408

Spectrum4_000527

Spectrum5_000947

STOCK1N-34341

Supracyclin

UNII-334895S862

UPCMLD-DP021

UPCMLD-DP021:001

Vibramycin

Vibramycin (*monohydrate)

Vibramycin Novum

Vibramycine

Vibra-tabs

Vibravenos

Vivox (*Hyclate)

Anti-Infective Agents

Phase 2, Phase 3

Antiparasitic Agents

Phase 2, Phase 3

Hormone Antagonists

Phase 2, Phase 3

Antimalarials

Phase 2, Phase 3

Anti-Inflammatory Agents

Phase 2, Phase 3

Antiprotozoal Agents

Phase 2, Phase 3

Antineoplastic Agents, Hormonal

Phase 2, Phase 3

Anti-Bacterial Agents

Phase 2, Phase 3

glucocorticoids

Phase 2, Phase 3

Hormones

Phase 2, Phase 3

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	The Effect of Prednisone Versus Doxycycline in Active, Moderately Severe Graves' Orbitopathy: A Randomized, Multi-center, Double-blind, Parallel-controlled Trial	Unknown status	NCT01809444	Phase 2, Phase 3	Prednisone+placebo of Doxycycline;Doxycycline+placebo of Prednisone

Search NIH Clinical Center for Endocrine Exophthalmos

Sources

Genetic Tests for Endocrine Exophthalmos

Sources

Anatomical Context for Endocrine Exophthalmos

MalaCards organs/tissues related to Endocrine Exophthalmos:

⁴⁰

Thyroid, Eye, Lung, B Cells, Thymus, Breast, T Cells

Sources

Publications for Endocrine Exophthalmos

Articles related to Endocrine Exophthalmos:

(show top 50) (show all 177)

#	Title	Authors	PMID	Year
1	Correction of lid retraction and exophthalmos. ⁶¹	Baldeschi L	18453764	2008
2	[Screening for endocrine exophthalmos-associated genes/cDNA fragments]. ⁶¹	Zheng J...Gong R	16706372	2006
3	Surgical treatment of endocrine exophthalmos by removal of orbital fat: clinical experience. ⁶¹	Ferreira MC...Alves CA	12436178	2002
4	Graves' disease of the orbit. ⁶¹	Weber AL...Sabates NR	8919134	1996
5	[Endocrine exophthalmos]. ⁶¹	Apostol S...Carstocea B	8714104	1996
6	[The treatment of residual exophthalmos by resection of the orbital fat]. ⁶¹	Ferreira MC...Alves CA	1340614	1992
7	Decompression of the orbit using a lateral rhinotomy approach in patients with malignant endocrine exophthalmos. ⁶¹	Petruson B...Frisen L	2350895	1990
8	Optic nerve involvement in endocrine exophthalmos. ⁶¹	Haddad HM	2079900	1990
9	Eye muscle antibodies in endocrine exophthalmos. Clinical and serological observations. ⁶¹	Kahaly G...Pfeiffer EF	2744719	1989
10	[Personal experience in the study of thyroid autoimmunity and endocrine exophthalmos]. ⁶¹	Winand R	2575920	1989
11	[The role of episcleral venous pressure in the development of secondary glaucomas]. ⁶¹	Jorgensen JS...Guthoff R	3210642	1988
12	[The treatment of endocrine exophthalmos]. ⁶¹	Winand R...Mahieu P	3399762	1988
13	[The medical treatment of endocrine exophthalmos]. ⁶¹	Glinoer D	3268307	1988
14	[The use of botulinum toxin in endocrine exophthalmos]. ⁶¹	Roggenkamper P	3273259	1988
15	[Surgery of the orbit in endocrine exophthalmos. Preliminary results of a new approach to orbital decompression in Basedow orbital diseases]. ⁶¹	Koornneef L	3268304	1988
16	Endocrine exophthalmos conservative management. ⁶¹	Haddad HM	3508403	1987
17	Enhanced prednisolone elimination: a possible cause for failure of glucocorticoid therapy in Graves' ophthalmopathy. ⁶¹	Legler UF	3583222	1987
18	[Importance of the assay of T3 and T4 tears and plasma for the diagnosis of endocrine exophthalmos]. ⁶¹	Glomaud J...Liotet S	3448120	1987
19	[Glaucoma in endocrine exophthalmus]. ⁶¹	Buschmann W	3754914	1986
20	Autoimmune thyroid disease. ⁶¹	Bottazzo GF...Doniach D	2871804	1986
21	[Operative therapy of severe endocrine exophthalmos]. ⁶¹	Buschmann W...Richter W	3754842	1986
22	Transantral orbital decompression in the treatment of Graves' disease. ⁶¹	Grahne B...Tommila V	3840193	1985
23	Orbital decompression in endocrine exophthalmos of Graves' disease. ⁶¹	Lamberg BA...Valimaki M	3839618	1985
24	T-lymphocyte-subsets in endocrine exophthalmos. ⁶¹	Cenmamo G...Castello G	3879963	1985
25	Surgical treatment for malignant exophthalmos of endocrine origin. ⁶¹	Hanabury MR...Chandler AC	6472017	1984
26	[Ethmoidectomy and orbital decompression in endocrine ophthalmopathy]. ⁶¹	Richter WC...Buschmann W	6548280	1984
27	[Ophthalmo-rhinosurgical decompression operation in malignant endocrine exophthalmus]. ⁶¹	Buschmann W...Richter W	6548269	1984
28	[Malignant endocrine exophthalmos. Therapeutic problems]. ⁶¹	Arnaud B...Esmenjaud E	6549503	1984
29	Management of inadequate transantral orbital decompression with extended lateral orbitotomy. ⁶¹	Hurwitz J...Rosenstock T	6688372	1983
30	[Surgical treatment of malignant endocrine exophthalmos]. ⁶¹	Busse H...Muller RP	6865258	1983
31	[Myxedema tuberosum atypicum (Jadassohn-Doesserkker, 1916) in the clinical picture of the myxodermias and in the normal course of Graves-Basedow's disease]. ⁶¹	Rabello FE...Cordeiro JG	6366397	1983
32	D-scan ultrasonography of orbital lesion. ⁶¹	Ito N...Minei M	6855013	1983
33	Autoimmune endocrine exophthalmos. ⁶¹		6129469	1982
34	[Endocrine exophthalmos and autoimmune thyroiditis]. ⁶¹	Francois JH...Rateau J	6897375	1982
35	Tests of thyroid function important to the ophthalmologist. ⁶¹	Hurwitz JJ	6809298	1982
36	Computerized tomography in endocrine exophthalmos: report of a case. ⁶¹	Solomon A...Greenwald M	6896413	1982
37	The effect of anterior orbital decompression on motility in thyroid exophthalmos. ⁶¹	Dixon R...Lesser GR	7335293	1981
38	Plasma exchange in conjunction with immunosuppressive drug therapy in the treatment of endocrine exophthalmos. ⁶¹	Sawers JS...Donaldson AA	6896074	1981
39	[Endocrine exophthalmos]. ⁶¹	Gilboa Y...Brauman A	6895880	1981
40	[Value of the scanner in the evaluation of endocrine exophthalmos]. ⁶¹	Brasseur G...Langlois J	6895611	1981
41	Endocrine exophthalmos. ⁶¹	Nathan MD...Porubsky ES	6894358	1981
42	Endocrine exophthalmos or orbital pseudotumour. ⁶¹	Jellinek EH	6110019	1981
43	Serum thyroglobulin, its autoantibody and thyroid stimulating antibodies in the endocrine exophthalmos. ⁶¹	Feldt-Rasmussen U...Date J	6894054	1981
44	Endocrine exophthalmos or orbital pseudotumour. ⁶¹	Feek CM...Toft AD	6109880	1981
45	[Endocrine exophthalmos. New nosological proposal and current therapeutic trends]. ⁶¹	Maiello M	7006014	1980
46	Transantral orbital decompression for endocrine exophthalmos--an appraisal. ⁶¹	Shaw HJ	6893600	1980
47	Endocrine exophthalmos; conservative management. ⁶¹	Haddad HM	6938804	1980
48	Progress in endocrine exophthalmos. ⁶¹	Havard CW	582020	1979
49	[Hyperthyroidism: diagnosis (author's transl)]. ⁶¹	Horster FA	104101	1978
50	Ultrasonography and computer tomography in orbital diagnosis. With special reference to dysthyroid ophthalmopathy. ⁶¹	Fledelius HC...Glydensted C	211790	1978

Sources

Genes for Endocrine Exophthalmos

Genes related to Endocrine Exophthalmos (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TG	Thyroglobulin	Protein Coding	5.78	DISEASES inferred ¹⁵
2	KCNJ18	Potassium Inwardly Rectifying Channel Subfamily J Member 18	Protein Coding	5.77	DISEASES inferred ¹⁵
3	HSD17B10	Hydroxysteroid 17-Beta Dehydrogenase 10	Protein Coding	5.12	DISEASES inferred ¹⁵
4	SHANK2	SH3 And Multiple Ankyrin Repeat Domains 2	Protein Coding	4.46	DISEASES inferred ¹⁵
5	SLC7A11	Solute Carrier Family 7 Member 11	Protein Coding	4.38	DISEASES inferred ¹⁵
6	POMC	Proopiomelanocortin	Protein Coding	4.31	DISEASES inferred ¹⁵
7	CD40LG	CD40 Ligand	Protein Coding	3.94	DISEASES inferred ¹⁵
8	BRD4	Bromodomain Containing 4	Protein Coding	3.86	DISEASES inferred ¹⁵
9	APOLD1	Apolipoprotein L Domain Containing 1	Protein Coding	3.82	DISEASES inferred ¹⁵
10	CD5	CD5 Molecule	Protein Coding	3.51	DISEASES inferred ¹⁵
11	IL6	Interleukin 6	Protein Coding	3.5	DISEASES inferred ¹⁵
12	MME	Membrane Metalloendopeptidase	Protein Coding	3.34	DISEASES inferred ¹⁵

Sources

Variations for Endocrine Exophthalmos

Sources

Expression for Endocrine Exophthalmos

Search GEO for disease gene expression data for Endocrine Exophthalmos.

Sources

Pathways for Endocrine Exophthalmos

Pathways related to Endocrine Exophthalmos according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.4	MME IL6 CD5
2	Hematopoietic cell lineage ³⁶	11.13	MME IL6 CD5
3	A-beta Pathways: Uptake and Degradation ⁶⁴	10.76	MME CD40LG
4	B Cell Development Pathways ⁶⁴	10.52	MME CD5 CD40LG

Sources

GO Terms for Endocrine Exophthalmos

Sources

Sources for Endocrine Exophthalmos

¹ BioSystems

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⁵⁷ OMIM via Orphanet

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⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia