MCID: END034
MIFTS: 32

Endocrine Exophthalmos

Categories: Bone diseases
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Aliases & Classifications for Endocrine Exophthalmos

MalaCards integrated aliases for Endocrine Exophthalmos:

Name: Endocrine Exophthalmos 11 14 75
Thyroid Associated Opthalmopathies 71
Endocrine Exopthalmos 71

Classifications:



External Ids:

Disease Ontology 11 DOID:12359
ICD9CM 34 376.2
SNOMED-CT 68 53061005
UMLS 71 C0155264 C0339143

Summaries for Endocrine Exophthalmos

MalaCards based summary: Endocrine Exophthalmos, also known as thyroid associated opthalmopathies, is related to graves disease 1 and hypothyroidism, congenital, nongoitrous, 2. An important gene associated with Endocrine Exophthalmos is TG (Thyroglobulin), and among its related pathways/superpathways are Pluripotent stem cell differentiation pathway and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The drugs Prednisone and Oxytetracycline have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and eye, and related phenotypes are endocrine/exocrine gland and immune system

Related Diseases for Endocrine Exophthalmos

Diseases related to Endocrine Exophthalmos via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 graves disease 1 30.4 TSHR TPO TG
2 hypothyroidism, congenital, nongoitrous, 2 30.3 TSHR TG
3 graves' disease 30.1 TSHR TPO TG
4 hashimoto thyroiditis 29.8 TSHR TPO TG
5 graves ophthalmopathy 29.7 TSHR TG IL6
6 endemic goiter 29.6 TSHR TPO TG
7 myxedema 29.6 TSHR TPO TG
8 hypothyroidism 29.4 TSHR TPO TG BGLAP
9 thyroiditis 29.2 TSHR TPO TG IL6
10 hyperthyroidism 29.0 TSHR TPO TG IL6 BGLAP
11 goiter 28.7 TSHR TPO TG IL6 BGLAP
12 middle ear adenocarcinoma 10.2 TG PDX1
13 neonatal thyrotoxicosis 10.1 TSHR TG
14 spindle epithelial tumor with thymus-like differentiation tumor 10.1 TG CD5
15 struma ovarii 10.1 TSHR TG
16 papillary thymic adenocarcinoma 10.1 TG CD5
17 epithelial malignant thymoma 10.1 TG CD5
18 parathyroid gland disease 10.1 TG BGLAP
19 ectopic thymus 10.1 TG CD5
20 dendritic cell thymoma 10.1 TG CD5
21 hypothyroidism, congenital, nongoitrous, 1 10.1 TSHR TG
22 thyroid hormone resistance, generalized, autosomal dominant 10.1 TSHR TG
23 acute thyroiditis 10.1 TPO TG
24 mechanical strabismus 10.1 TPO TG
25 nonencapsulated sclerosing carcinoma 10.1 TPO TG
26 thyroid cancer, nonmedullary, 2 10.1 TSHR TG
27 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.1 TPO TG
28 hypothyroidism, congenital, nongoitrous, 4 10.1 TPO TG
29 chronic spontaneous urticaria 10.0 TPO TG
30 hypothyroidism, congenital, nongoitrous, 3 10.0
31 autoimmune gastritis 10.0 TPO TG
32 immunodeficiency 58 10.0 TPO TG
33 adrenal cortical hypofunction 10.0 TPO TG
34 pernicious anemia 10.0 TPO TG
35 hypotropia 10.0 TSHR TPO
36 familial thyroid dyshormonogenesis 10.0 TPO TG
37 hyperthyroxinemia 10.0 TSHR TPO
38 euthyroid sick syndrome 9.9 TG IL6
39 hypoadrenocorticism, familial 9.9 TPO TG
40 osteitis fibrosa 9.9 IL6 BGLAP
41 chronic recurrent multifocal osteomyelitis 9.9 IL6 BGLAP
42 periapical periodontitis 9.9 IL6 BGLAP
43 dental pulp disease 9.9 IL6 BGLAP
44 orbital disease 9.9 TSHR TG CD5
45 kearns-sayre syndrome 9.9
46 excessive tearing 9.9
47 mammary paget's disease 9.9
48 occlusion of gallbladder 9.9 SLC7A11 IL6
49 bacterial sepsis 9.9 LY96 IL6
50 iodine hypothyroidism 9.9 TSHR TPO TG

Graphical network of the top 20 diseases related to Endocrine Exophthalmos:



Diseases related to Endocrine Exophthalmos

Symptoms & Phenotypes for Endocrine Exophthalmos

MGI Mouse Phenotypes related to Endocrine Exophthalmos:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.63 BGLAP IL6 PDX1 TG TPO TSHR
2 immune system MP:0005387 9.61 BGLAP CD5 IL6 LY96 PDX1 SLC7A11
3 hearing/vestibular/ear MP:0005377 9.56 SLC7A11 TG TPO TSHR
4 hematopoietic system MP:0005397 9.23 BGLAP CD5 IL6 LY96 SLC7A11 TG

Drugs & Therapeutics for Endocrine Exophthalmos

Drugs for Endocrine Exophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
2
Oxytetracycline Approved, Investigational, Vet_approved Phase 2, Phase 3 79-57-2 54715139 54675779
3
Doxycycline Approved, Investigational, Vet_approved Phase 2, Phase 3 564-25-0 54671203
4 Antineoplastic Agents, Hormonal Phase 2, Phase 3
5 Anti-Bacterial Agents Phase 2, Phase 3
6 Anti-Infective Agents Phase 2, Phase 3
7 Antiprotozoal Agents Phase 2, Phase 3
8 Hormones Phase 2, Phase 3
9 Antiparasitic Agents Phase 2, Phase 3
10 Hormone Antagonists Phase 2, Phase 3
11 Antimalarials Phase 2, Phase 3
12 glucocorticoids Phase 2, Phase 3
13 Anti-Inflammatory Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect of Prednisone Versus Doxycycline in Active, Moderately Severe Graves' Orbitopathy: A Randomized, Multi-center, Double-blind, Parallel-controlled Trial Unknown status NCT01809444 Phase 2, Phase 3 Prednisone+placebo of Doxycycline;Doxycycline+placebo of Prednisone

Search NIH Clinical Center for Endocrine Exophthalmos

Genetic Tests for Endocrine Exophthalmos

Anatomical Context for Endocrine Exophthalmos

Organs/tissues related to Endocrine Exophthalmos:

MalaCards : Thyroid, Bone, Eye, Pituitary

Publications for Endocrine Exophthalmos

Articles related to Endocrine Exophthalmos:

(show top 50) (show all 177)
# Title Authors PMID Year
1
Correction of lid retraction and exophthalmos. 62
18453764 2008
2
[Screening for endocrine exophthalmos-associated genes/cDNA fragments]. 62
16706372 2006
3
Surgical treatment of endocrine exophthalmos by removal of orbital fat: clinical experience. 62
12436178 2002
4
Graves' disease of the orbit. 62
8919134 1996
5
[Endocrine exophthalmos]. 62
8714104 1996
6
[The treatment of residual exophthalmos by resection of the orbital fat]. 62
1340614 1992
7
Decompression of the orbit using a lateral rhinotomy approach in patients with malignant endocrine exophthalmos. 62
2350895 1990
8
Optic nerve involvement in endocrine exophthalmos. 62
2079900 1990
9
Eye muscle antibodies in endocrine exophthalmos. Clinical and serological observations. 62
2744719 1989
10
[Personal experience in the study of thyroid autoimmunity and endocrine exophthalmos]. 62
2575920 1989
11
[The role of episcleral venous pressure in the development of secondary glaucomas]. 62
3210642 1988
12
[The treatment of endocrine exophthalmos]. 62
3399762 1988
13
[Surgery of the orbit in endocrine exophthalmos. Preliminary results of a new approach to orbital decompression in Basedow orbital diseases]. 62
3268304 1988
14
[The use of botulinum toxin in endocrine exophthalmos]. 62
3273259 1988
15
[The medical treatment of endocrine exophthalmos]. 62
3268307 1988
16
Endocrine exophthalmos conservative management. 62
3508403 1987
17
Enhanced prednisolone elimination: a possible cause for failure of glucocorticoid therapy in Graves' ophthalmopathy. 62
3583222 1987
18
[Importance of the assay of T3 and T4 tears and plasma for the diagnosis of endocrine exophthalmos]. 62
3448120 1987
19
[Glaucoma in endocrine exophthalmus]. 62
3754914 1986
20
Autoimmune thyroid disease. 62
2871804 1986
21
[Operative therapy of severe endocrine exophthalmos]. 62
3754842 1986
22
Transantral orbital decompression in the treatment of Graves' disease. 62
3840193 1985
23
Orbital decompression in endocrine exophthalmos of Graves' disease. 62
3839618 1985
24
T-lymphocyte-subsets in endocrine exophthalmos. 62
3879963 1985
25
Surgical treatment for malignant exophthalmos of endocrine origin. 62
6472017 1984
26
[Ethmoidectomy and orbital decompression in endocrine ophthalmopathy]. 62
6548280 1984
27
[Ophthalmo-rhinosurgical decompression operation in malignant endocrine exophthalmus]. 62
6548269 1984
28
[Malignant endocrine exophthalmos. Therapeutic problems]. 62
6549503 1984
29
Management of inadequate transantral orbital decompression with extended lateral orbitotomy. 62
6688372 1983
30
[Surgical treatment of malignant endocrine exophthalmos]. 62
6865258 1983
31
D-scan ultrasonography of orbital lesion. 62
6855013 1983
32
[Myxedema tuberosum atypicum (Jadassohn-Doesserkker, 1916) in the clinical picture of the myxodermias and in the normal course of Graves-Basedow's disease]. 62
6366397 1983
33
Autoimmune endocrine exophthalmos. 62
6129469 1982
34
[Endocrine exophthalmos and autoimmune thyroiditis]. 62
6897375 1982
35
Tests of thyroid function important to the ophthalmologist. 62
6809298 1982
36
Computerized tomography in endocrine exophthalmos: report of a case. 62
6896413 1982
37
The effect of anterior orbital decompression on motility in thyroid exophthalmos. 62
7335293 1981
38
Plasma exchange in conjunction with immunosuppressive drug therapy in the treatment of endocrine exophthalmos. 62
6896074 1981
39
[Endocrine exophthalmos]. 62
6895880 1981
40
[Value of the scanner in the evaluation of endocrine exophthalmos]. 62
6895611 1981
41
Endocrine exophthalmos. 62
6894358 1981
42
Serum thyroglobulin, its autoantibody and thyroid stimulating antibodies in the endocrine exophthalmos. 62
6894054 1981
43
Endocrine exophthalmos or orbital pseudotumour. 62
6110019 1981
44
Endocrine exophthalmos or orbital pseudotumour. 62
6109880 1981
45
[Endocrine exophthalmos. New nosological proposal and current therapeutic trends]. 62
7006014 1980
46
Transantral orbital decompression for endocrine exophthalmos--an appraisal. 62
6893600 1980
47
Endocrine exophthalmos; conservative management. 62
6938804 1980
48
Progress in endocrine exophthalmos. 62
582020 1979
49
[Hyperthyroidism: diagnosis (author's transl)]. 62
104101 1978
50
Ultrasonography and computer tomography in orbital diagnosis. With special reference to dysthyroid ophthalmopathy. 62
211790 1978

Variations for Endocrine Exophthalmos

Expression for Endocrine Exophthalmos

Search GEO for disease gene expression data for Endocrine Exophthalmos.

Pathways for Endocrine Exophthalmos

GO Terms for Endocrine Exophthalmos

Biological processes related to Endocrine Exophthalmos according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 thyroid hormone generation GO:0006590 9.56 TPO TG
2 endocrine pancreas development GO:0031018 9.5 PDX1 IL6
3 hormone biosynthetic process GO:0042446 9.46 TPO TG
4 response to organic cyclic compound GO:0014070 9.26 SLC7A11 PDX1 BGLAP
5 response to glucocorticoid GO:0051384 9.1 PDX1 IL6 BGLAP

Sources for Endocrine Exophthalmos

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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