MCID: END034
MIFTS: 31

Endocrine Exophthalmos

Categories: Eye diseases

Aliases & Classifications for Endocrine Exophthalmos

MalaCards integrated aliases for Endocrine Exophthalmos:

Name: Endocrine Exophthalmos 12 15
Thyroid Associated Opthalmopathies 71
Endocrine Exopthalmos 71

Classifications:



External Ids:

Disease Ontology 12 DOID:12359
ICD9CM 34 376.2
SNOMED-CT 67 53061005
UMLS 71 C0155264 C0339143

Summaries for Endocrine Exophthalmos

MalaCards based summary : Endocrine Exophthalmos, also known as thyroid associated opthalmopathies, is related to graves disease 1 and orbital disease. An important gene associated with Endocrine Exophthalmos is TG (Thyroglobulin), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. The drugs Prednisone and Oxytetracycline have been mentioned in the context of this disorder. Affiliated tissues include thyroid, eye and lung, and related phenotypes are Dynamic nuclei (hole, folded or small irregular) and integument

Wikipedia : 74 Graves ophthalmopathy,also known as thyroid eye disease (TED), is an autoimmune inflammatory disorder of... more...

Related Diseases for Endocrine Exophthalmos

Diseases related to Endocrine Exophthalmos via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 graves disease 1 30.5 TG POMC KCNJ18
2 orbital disease 30.3 TG CD40LG
3 hyperthyroidism 30.3 TG POMC KCNJ18
4 myxedema 30.3 TG POMC
5 exophthalmos 11.0
6 acute thyroiditis 10.4 TG POMC
7 hypoadrenalism 10.4 TG POMC
8 ovarian serous adenofibroma 10.4 TG POMC
9 mechanical strabismus 10.4 TG CD40LG
10 adrenal cortical hypofunction 10.3 TG POMC
11 trichinosis 10.3 POMC CD40LG
12 nasal cavity olfactory neuroblastoma 10.3 TG MME
13 uveoparotid fever 10.2 POMC CD40LG
14 hairy tongue 10.2 POMC CD40LG
15 cranial nerve palsy 10.2 POMC CD40LG
16 hyperglobulinemic purpura 10.2 CD40LG BRD4
17 spindle epithelial tumor with thymus-like differentiation tumor 10.2 TG CD5
18 papillary thymic adenocarcinoma 10.2 TG CD5
19 epithelial malignant thymoma 10.2 TG CD5
20 graves' disease 10.2
21 ectopic thymus 10.2 TG CD5
22 hilar lung carcinoma 10.2 MME CD40LG
23 lung hilum cancer 10.2 MME CD40LG
24 anal spasm 10.2 POMC APOLD1
25 cryoglobulinemia, familial mixed 10.1 CD5 CD40LG
26 waldenstroem's macroglobulinemia 10.1 CD5 CD40LG
27 splenic infarction 10.1 CD5 CD40LG
28 fallopian tube endometrioid adenocarcinoma 10.1 MME APOLD1
29 exophthalmic ophthalmoplegia 10.1 POMC KCNJ18 BRD4
30 alpha chain disease 10.0 CD5 CD40LG
31 hashimoto thyroiditis 10.0
32 thyroiditis 10.0
33 bladder lymphoma 10.0 MME CD5
34 prostate lymphoma 10.0 MME CD5
35 epiglottis neoplasm 10.0 MME CD5
36 liver lymphoma 10.0 MME CD5
37 bone lymphoma 10.0 MME CD5
38 colon lymphoma 10.0 MME CD5
39 intravascular large b-cell lymphoma 10.0 MME CD5
40 lung lymphoma 10.0 MME CD5
41 breast lymphoma 10.0 MME CD5
42 thyroid gland medullary carcinoma 10.0 TG POMC
43 sclerosing hepatic carcinoma 10.0 MME CD5
44 gastrointestinal lymphoma 10.0 MME CD5
45 composite lymphoma 10.0 MME CD5
46 adult lymphoma 10.0 MME CD5
47 tracheal lymphoma 10.0 MME CD5
48 acute adrenal insufficiency 10.0 POMC IL6
49 spinal cord lymphoma 10.0 MME CD5
50 breast osteosarcoma 10.0 MME CD5

Graphical network of the top 20 diseases related to Endocrine Exophthalmos:



Diseases related to Endocrine Exophthalmos

Symptoms & Phenotypes for Endocrine Exophthalmos

GenomeRNAi Phenotypes related to Endocrine Exophthalmos according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Dynamic nuclei (hole, folded or small irregular) GR00257-A-1 9.17 BRD4 CD40LG CD5 POMC SHANK2 SLC7A11

MGI Mouse Phenotypes related to Endocrine Exophthalmos:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.5 CD40LG CD5 IL6 MME POMC SLC7A11
2 nervous system MP:0003631 9.23 CD40LG CD5 IL6 MME POMC SHANK2

Drugs & Therapeutics for Endocrine Exophthalmos

Drugs for Endocrine Exophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
2
Oxytetracycline Approved, Investigational, Vet_approved Phase 2, Phase 3 79-57-2 5280972 54715139
3
Doxycycline Approved, Investigational, Vet_approved Phase 2, Phase 3 564-25-0 54671203
4 Anti-Infective Agents Phase 2, Phase 3
5 Antiparasitic Agents Phase 2, Phase 3
6 Hormone Antagonists Phase 2, Phase 3
7 Antimalarials Phase 2, Phase 3
8 Anti-Inflammatory Agents Phase 2, Phase 3
9 Antiprotozoal Agents Phase 2, Phase 3
10 Antineoplastic Agents, Hormonal Phase 2, Phase 3
11 Anti-Bacterial Agents Phase 2, Phase 3
12 glucocorticoids Phase 2, Phase 3
13 Hormones Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect of Prednisone Versus Doxycycline in Active, Moderately Severe Graves' Orbitopathy: A Randomized, Multi-center, Double-blind, Parallel-controlled Trial Unknown status NCT01809444 Phase 2, Phase 3 Prednisone+placebo of Doxycycline;Doxycycline+placebo of Prednisone

Search NIH Clinical Center for Endocrine Exophthalmos

Genetic Tests for Endocrine Exophthalmos

Anatomical Context for Endocrine Exophthalmos

MalaCards organs/tissues related to Endocrine Exophthalmos:

40
Thyroid, Eye, Lung, B Cells, Thymus, Breast, T Cells

Publications for Endocrine Exophthalmos

Articles related to Endocrine Exophthalmos:

(show top 50) (show all 177)
# Title Authors PMID Year
1
Correction of lid retraction and exophthalmos. 61
18453764 2008
2
[Screening for endocrine exophthalmos-associated genes/cDNA fragments]. 61
16706372 2006
3
Surgical treatment of endocrine exophthalmos by removal of orbital fat: clinical experience. 61
12436178 2002
4
Graves' disease of the orbit. 61
8919134 1996
5
[Endocrine exophthalmos]. 61
8714104 1996
6
[The treatment of residual exophthalmos by resection of the orbital fat]. 61
1340614 1992
7
Decompression of the orbit using a lateral rhinotomy approach in patients with malignant endocrine exophthalmos. 61
2350895 1990
8
Optic nerve involvement in endocrine exophthalmos. 61
2079900 1990
9
Eye muscle antibodies in endocrine exophthalmos. Clinical and serological observations. 61
2744719 1989
10
[Personal experience in the study of thyroid autoimmunity and endocrine exophthalmos]. 61
2575920 1989
11
[The role of episcleral venous pressure in the development of secondary glaucomas]. 61
3210642 1988
12
[The treatment of endocrine exophthalmos]. 61
3399762 1988
13
[The medical treatment of endocrine exophthalmos]. 61
3268307 1988
14
[The use of botulinum toxin in endocrine exophthalmos]. 61
3273259 1988
15
[Surgery of the orbit in endocrine exophthalmos. Preliminary results of a new approach to orbital decompression in Basedow orbital diseases]. 61
3268304 1988
16
Endocrine exophthalmos conservative management. 61
3508403 1987
17
Enhanced prednisolone elimination: a possible cause for failure of glucocorticoid therapy in Graves' ophthalmopathy. 61
3583222 1987
18
[Importance of the assay of T3 and T4 tears and plasma for the diagnosis of endocrine exophthalmos]. 61
3448120 1987
19
[Glaucoma in endocrine exophthalmus]. 61
3754914 1986
20
Autoimmune thyroid disease. 61
2871804 1986
21
[Operative therapy of severe endocrine exophthalmos]. 61
3754842 1986
22
Transantral orbital decompression in the treatment of Graves' disease. 61
3840193 1985
23
Orbital decompression in endocrine exophthalmos of Graves' disease. 61
3839618 1985
24
T-lymphocyte-subsets in endocrine exophthalmos. 61
3879963 1985
25
Surgical treatment for malignant exophthalmos of endocrine origin. 61
6472017 1984
26
[Ethmoidectomy and orbital decompression in endocrine ophthalmopathy]. 61
6548280 1984
27
[Ophthalmo-rhinosurgical decompression operation in malignant endocrine exophthalmus]. 61
6548269 1984
28
[Malignant endocrine exophthalmos. Therapeutic problems]. 61
6549503 1984
29
Management of inadequate transantral orbital decompression with extended lateral orbitotomy. 61
6688372 1983
30
[Surgical treatment of malignant endocrine exophthalmos]. 61
6865258 1983
31
[Myxedema tuberosum atypicum (Jadassohn-Doesserkker, 1916) in the clinical picture of the myxodermias and in the normal course of Graves-Basedow's disease]. 61
6366397 1983
32
D-scan ultrasonography of orbital lesion. 61
6855013 1983
33
Autoimmune endocrine exophthalmos. 61
6129469 1982
34
[Endocrine exophthalmos and autoimmune thyroiditis]. 61
6897375 1982
35
Tests of thyroid function important to the ophthalmologist. 61
6809298 1982
36
Computerized tomography in endocrine exophthalmos: report of a case. 61
6896413 1982
37
The effect of anterior orbital decompression on motility in thyroid exophthalmos. 61
7335293 1981
38
Plasma exchange in conjunction with immunosuppressive drug therapy in the treatment of endocrine exophthalmos. 61
6896074 1981
39
[Endocrine exophthalmos]. 61
6895880 1981
40
[Value of the scanner in the evaluation of endocrine exophthalmos]. 61
6895611 1981
41
Endocrine exophthalmos. 61
6894358 1981
42
Endocrine exophthalmos or orbital pseudotumour. 61
6110019 1981
43
Serum thyroglobulin, its autoantibody and thyroid stimulating antibodies in the endocrine exophthalmos. 61
6894054 1981
44
Endocrine exophthalmos or orbital pseudotumour. 61
6109880 1981
45
[Endocrine exophthalmos. New nosological proposal and current therapeutic trends]. 61
7006014 1980
46
Transantral orbital decompression for endocrine exophthalmos--an appraisal. 61
6893600 1980
47
Endocrine exophthalmos; conservative management. 61
6938804 1980
48
Progress in endocrine exophthalmos. 61
582020 1979
49
[Hyperthyroidism: diagnosis (author's transl)]. 61
104101 1978
50
Ultrasonography and computer tomography in orbital diagnosis. With special reference to dysthyroid ophthalmopathy. 61
211790 1978

Variations for Endocrine Exophthalmos

Expression for Endocrine Exophthalmos

Search GEO for disease gene expression data for Endocrine Exophthalmos.

Pathways for Endocrine Exophthalmos

Pathways related to Endocrine Exophthalmos according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 MME IL6 CD5
2 11.13 MME IL6 CD5
3 10.76 MME CD40LG
4 10.52 MME CD5 CD40LG

GO Terms for Endocrine Exophthalmos

Sources for Endocrine Exophthalmos

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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