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MCID: END034
MIFTS: 32

Endocrine Exophthalmos

Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Endocrine Exophthalmos

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MalaCards integrated aliases for Endocrine Exophthalmos:

Name: Endocrine Exophthalmos 12 15
Thyroid Associated Opthalmopathies 71
Endocrine Exopthalmos 71

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12359
ICD9CM 34 376.2
UMLS 71 C0155264 C0339143
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Summaries for Endocrine Exophthalmos

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MalaCards based summary : Endocrine Exophthalmos, also known as thyroid associated opthalmopathies, is related to exophthalmos and mechanical strabismus. An important gene associated with Endocrine Exophthalmos is TG (Thyroglobulin), and among its related pathways/superpathways are Hematopoietic Stem Cells and Lineage-specific Markers and Hematopoietic cell lineage. The drugs Prednisone and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include thyroid, eye and bone, and related phenotypes are immune system and integument

Wikipedia : 74 Graves ophthalmopathy, also known as thyroid eye disease (TED), is an autoimmune inflammatory disorder... more...

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Related Diseases for Endocrine Exophthalmos

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Diseases related to Endocrine Exophthalmos via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 exophthalmos 11.0
2 mechanical strabismus 10.3 TG CD40LG
3 spindle epithelial tumor with thymus-like differentiation tumor 10.3 TG CD5
4 papillary thymic adenocarcinoma 10.2 TG CD5
5 epithelial malignant thymoma 10.2 TG CD5
6 dendritic cell thymoma 10.2 TG CD5
7 ectopic thymus 10.2 TG CD5
8 paralytic poliomyelitis 10.2 CD40LG APOLD1
9 poliomyelitis 10.2 CD40LG APOLD1
10 graves' disease 10.2
11 cryoglobulinemia, familial mixed 10.2 CD5 CD40LG
12 alpha chain disease 10.2 CD5 CD40LG
13 graves disease 1 10.1
14 waldenstroem's macroglobulinemia 10.1 CD5 CD40LG
15 euthyroid sick syndrome 10.1 TG IL6
16 subacute thyroiditis 10.1 TG IL6
17 aortitis 10.1 IL6 CD40LG
18 leukemia, chronic lymphocytic 2 10.1 CD5 ATM
19 myelitis 10.1 IL6 CD40LG
20 tenosynovitis 10.1 IL6 CD40LG
21 blastomycosis 10.1 IL6 CD40LG
22 pyuria 10.1 IL6 CD40LG
23 scleral disease 10.1 IL6 CD40LG
24 lung abscess 10.1 IL6 CD40LG
25 chlamydia pneumonia 10.1 IL6 CD40LG
26 idiopathic neutropenia 10.1 IL6 CD40LG
27 iritis 10.1 IL6 CD40LG
28 iridocyclitis 10.1 IL6 CD40LG
29 chorioretinitis 10.1 IL6 CD40LG
30 laryngitis 10.1 IL6 CD40LG
31 african tick-bite fever 10.1 IL6 CD40LG
32 anemia, autoimmune hemolytic 10.1 CD5 CD40LG
33 epididymis disease 10.1 IL6 CD40LG
34 vaginal discharge 10.1 IL6 CD40LG
35 orchitis 10.1 IL6 CD40LG
36 trichomoniasis 10.1 IL6 CD40LG
37 fungal meningitis 10.1 IL6 CD40LG
38 hantavirus hemorrhagic fever with renal syndrome 10.1 IL6 CD40LG
39 chromosome 13q14 deletion syndrome 10.1 CD5 ATM
40 central nervous system vasculitis 10.1 IL6 CD40LG
41 urethritis 10.1 IL6 CD40LG
42 tendinitis 10.1 IL6 CD40LG
43 hashimoto thyroiditis 10.1
44 thyroiditis 10.1
45 hyperthyroidism 10.1
46 polyradiculopathy 10.1 IL6 CD40LG
47 erysipelas 10.1 IL6 CD40LG
48 viral pneumonia 10.0 IL6 CD40LG
49 primary systemic mycosis 10.0 IL6 CD40LG
50 pneumocystosis 10.0 IL6 CD40LG

Graphical network of the top 20 diseases related to Endocrine Exophthalmos:



Diseases related to Endocrine Exophthalmos
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Symptoms & Phenotypes for Endocrine Exophthalmos

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MGI Mouse Phenotypes related to Endocrine Exophthalmos:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.7 ATM CD40LG CD5 IL6 MME SLC7A11
2 integument MP:0010771 9.43 ATM CD40LG CD5 IL6 MME SLC7A11
3 nervous system MP:0003631 9.23 ATM CD40LG CD5 IL6 MME SHANK2
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Drugs & Therapeutics for Endocrine Exophthalmos

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Drugs for Endocrine Exophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
2
Doxycycline Approved, Investigational, Vet_approved Phase 2, Phase 3 564-25-0 54671203
3
Oxytetracycline Approved, Investigational, Vet_approved Phase 2, Phase 3 79-57-2 54715139 5280972
4 Hormones Phase 2, Phase 3
5 Hormone Antagonists Phase 2, Phase 3
6 Antineoplastic Agents, Hormonal Phase 2, Phase 3
7 glucocorticoids Phase 2, Phase 3
8 Anti-Infective Agents Phase 2, Phase 3
9 Antiprotozoal Agents Phase 2, Phase 3
10 Anti-Bacterial Agents Phase 2, Phase 3
11 Antiparasitic Agents Phase 2, Phase 3
12 Anti-Inflammatory Agents Phase 2, Phase 3
13 Antimalarials Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect of Prednisone Versus Doxycycline in Active, Moderately Severe Graves' Orbitopathy: A Randomized, Multi-center, Double-blind, Parallel-controlled Trial Unknown status NCT01809444 Phase 2, Phase 3 Prednisone+placebo of Doxycycline;Doxycycline+placebo of Prednisone

Search NIH Clinical Center for Endocrine Exophthalmos

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Genetic Tests for Endocrine Exophthalmos

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Anatomical Context for Endocrine Exophthalmos

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MalaCards organs/tissues related to Endocrine Exophthalmos:

40
Thyroid, Eye, Bone, Testes, Pituitary
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Publications for Endocrine Exophthalmos

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Articles related to Endocrine Exophthalmos:

(show top 50) (show all 177)
# Title Authors PMID Year
1
Correction of lid retraction and exophthalmos. 61
18453764 2008
2
[Screening for endocrine exophthalmos-associated genes/cDNA fragments]. 61
16706372 2006
3
Surgical treatment of endocrine exophthalmos by removal of orbital fat: clinical experience. 61
12436178 2002
4
Graves' disease of the orbit. 61
8919134 1996
5
[Endocrine exophthalmos]. 61
8714104 1996
6
[The treatment of residual exophthalmos by resection of the orbital fat]. 61
1340614 1992
7
Decompression of the orbit using a lateral rhinotomy approach in patients with malignant endocrine exophthalmos. 61
2350895 1990
8
Optic nerve involvement in endocrine exophthalmos. 61
2079900 1990
9
Eye muscle antibodies in endocrine exophthalmos. Clinical and serological observations. 61
2744719 1989
10
[Personal experience in the study of thyroid autoimmunity and endocrine exophthalmos]. 61
2575920 1989
11
[The role of episcleral venous pressure in the development of secondary glaucomas]. 61
3210642 1988
12
[The treatment of endocrine exophthalmos]. 61
3399762 1988
13
[The use of botulinum toxin in endocrine exophthalmos]. 61
3273259 1988
14
[The medical treatment of endocrine exophthalmos]. 61
3268307 1988
15
[Surgery of the orbit in endocrine exophthalmos. Preliminary results of a new approach to orbital decompression in Basedow orbital diseases]. 61
3268304 1988
16
Endocrine exophthalmos conservative management. 61
3508403 1987
17
Enhanced prednisolone elimination: a possible cause for failure of glucocorticoid therapy in Graves' ophthalmopathy. 61
3583222 1987
18
[Importance of the assay of T3 and T4 tears and plasma for the diagnosis of endocrine exophthalmos]. 61
3448120 1987
19
[Glaucoma in endocrine exophthalmus]. 61
3754914 1986
20
Autoimmune thyroid disease. 61
2871804 1986
21
[Operative therapy of severe endocrine exophthalmos]. 61
3754842 1986
22
Transantral orbital decompression in the treatment of Graves' disease. 61
3840193 1985
23
Orbital decompression in endocrine exophthalmos of Graves' disease. 61
3839618 1985
24
T-lymphocyte-subsets in endocrine exophthalmos. 61
3879963 1985
25
Surgical treatment for malignant exophthalmos of endocrine origin. 61
6472017 1984
26
[Ethmoidectomy and orbital decompression in endocrine ophthalmopathy]. 61
6548280 1984
27
[Ophthalmo-rhinosurgical decompression operation in malignant endocrine exophthalmus]. 61
6548269 1984
28
[Malignant endocrine exophthalmos. Therapeutic problems]. 61
6549503 1984
29
Management of inadequate transantral orbital decompression with extended lateral orbitotomy. 61
6688372 1983
30
[Surgical treatment of malignant endocrine exophthalmos]. 61
6865258 1983
31
[Myxedema tuberosum atypicum (Jadassohn-Doesserkker, 1916) in the clinical picture of the myxodermias and in the normal course of Graves-Basedow's disease]. 61
6366397 1983
32
D-scan ultrasonography of orbital lesion. 61
6855013 1983
33
Autoimmune endocrine exophthalmos. 61
6129469 1982
34
[Endocrine exophthalmos and autoimmune thyroiditis]. 61
6897375 1982
35
Tests of thyroid function important to the ophthalmologist. 61
6809298 1982
36
Computerized tomography in endocrine exophthalmos: report of a case. 61
6896413 1982
37
The effect of anterior orbital decompression on motility in thyroid exophthalmos. 61
7335293 1981
38
Plasma exchange in conjunction with immunosuppressive drug therapy in the treatment of endocrine exophthalmos. 61
6896074 1981
39
[Endocrine exophthalmos]. 61
6895880 1981
40
[Value of the scanner in the evaluation of endocrine exophthalmos]. 61
6895611 1981
41
Endocrine exophthalmos. 61
6894358 1981
42
Endocrine exophthalmos or orbital pseudotumour. 61
6110019 1981
43
Serum thyroglobulin, its autoantibody and thyroid stimulating antibodies in the endocrine exophthalmos. 61
6894054 1981
44
Endocrine exophthalmos or orbital pseudotumour. 61
6109880 1981
45
[Endocrine exophthalmos. New nosological proposal and current therapeutic trends]. 61
7006014 1980
46
Transantral orbital decompression for endocrine exophthalmos--an appraisal. 61
6893600 1980
47
Endocrine exophthalmos; conservative management. 61
6938804 1980
48
Progress in endocrine exophthalmos. 61
582020 1979
49
[Hyperthyroidism: diagnosis (author's transl)]. 61
104101 1978
50
Ultrasonography and computer tomography in orbital diagnosis. With special reference to dysthyroid ophthalmopathy. 61
211790 1978
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Variations for Endocrine Exophthalmos

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Expression for Endocrine Exophthalmos

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Search GEO for disease gene expression data for Endocrine Exophthalmos.
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Pathways for Endocrine Exophthalmos

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Pathways related to Endocrine Exophthalmos according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Hematopoietic Stem Cells and Lineage-specific Markers 64
11.2 MME IL6 CD5
2
Hematopoietic cell lineage 36
10.79 MME IL6 CD5
3
A-beta Uptake and Degradation 64
10.66 MME CD40LG
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GO Terms for Endocrine Exophthalmos

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Biological processes related to Endocrine Exophthalmos according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adult behavior GO:0030534 9.16 SLC7A11 SHANK2
2 replicative senescence GO:0090399 8.96 MME ATM
3 regulation of microglial cell activation GO:1903978 8.62 IL6 ATM
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Sources for Endocrine Exophthalmos

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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