MCID: END035
MIFTS: 48

Endocrine Gland Cancer

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Endocrine Gland Cancer

MalaCards integrated aliases for Endocrine Gland Cancer:

Name: Endocrine Gland Cancer 12 15
Malignant Neoplasm of Endocrine Gland 12 73
Endocrine Gland Neoplasms 44 73
Endocrine Neoplasm 12 55
Endocrine Cancer 29 55
Malignant Tumour of Endocrine Gland 12
Neoplasm of the Endocrine System 29
Neoplasm of Endocrine System 12
Carcinoma of Endocrine Gland 73
Neoplasm of Endocrine Gland 12
Malignant Endocrine Tumor 12
Endocrine Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:170
ICD10 33 C75.9
ICD9CM 35 194.9
MeSH 44 D004701
NCIt 50 C3010 C3575
SNOMED-CT 68 93780007

Summaries for Endocrine Gland Cancer

Disease Ontology : 12 An organ system cancer located in endocrine system that is characterized by uncontrolled cellular proliferation of the hormone producing glands of the endocrine system.

MalaCards based summary : Endocrine Gland Cancer, also known as malignant neoplasm of endocrine gland, is related to non-functioning pancreatic endocrine tumor and islet cell tumor. An important gene associated with Endocrine Gland Cancer is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Pathways in cancer and Integrated Breast Cancer Pathway. The drugs Afinitor and Sutent have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lung and liver, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Related Diseases for Endocrine Gland Cancer

Diseases related to Endocrine Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 208)
# Related Disease Score Top Affiliating Genes
1 non-functioning pancreatic endocrine tumor 34.0 SYP GAST CHGA
2 islet cell tumor 32.6 CHGA GAST IAPP SST VIP
3 wdha syndrome 32.5 SST VIP
4 multiple endocrine neoplasia, type i 32.5 CHGA GAST GNAS RET SST SYP
5 insulinoma 32.5 SST IAPP GCG CHGA
6 neuroendocrine tumor 32.2 SYP SST GAST CHGA
7 thyroid cancer 32.2 TG SST RET KDR GNAS CHGA
8 vipoma 32.0 CHGA GAST SST VIP
9 pancreatic cholera 32.0 GAST GCG SST VIP
10 thyroid carcinoma, familial medullary 30.5 CHGA GAST RET SST TG
11 carcinoid syndrome 30.4 SYP SST CHGA
12 glucagonoma 30.2 VIP SST CHGA
13 somatostatinoma 30.2 VIP SST CHGA
14 zollinger-ellison syndrome 30.2 SST GAST CHGA
15 adenoma 30.2 GNAS MLH1 RET SST
16 adenocarcinoma 30.2 GNAS KDR MLH1 RET
17 pancreatic somatostatinoma 30.2 SST SYP
18 pheochromocytoma 30.1 VIP SYP SST RET CHGA
19 hyperparathyroidism 30.1 CHGA GAST RET
20 paraganglioma 30.1 SYP SST RET CHGA
21 pancreatoblastoma 30.0 AFP CHGA SST SYP
22 mccune-albright syndrome 30.0 CYP19A1 GNAS SST
23 merkel cell carcinoma 30.0 CHGA SST SYP
24 atrophic gastritis 30.0 CHGA GAST SST
25 gastrinoma 30.0 CHGA GAST SST VIP
26 gastritis 30.0 AREG CHGA GAST
27 primary hyperparathyroidism 29.9 CHGA GAST RET
28 functioning pancreatic endocrine tumor 12.1
29 pancreatic neuroendocrine tumor 11.7
30 carney complex variant 11.4
31 pancreatic cancer 11.1
32 parathyroid carcinoma 11.1
33 adrenal carcinoma 11.1
34 multiple endocrine neoplasia 11.1
35 multiple endocrine neoplasia, type iib 11.1
36 non-functioning neuroendocrine tumor of pancreas 11.1
37 multiple endocrine neoplasia, type iia 11.0
38 carney complex, type 1 11.0
39 ureter small cell carcinoma 10.4 SYP CHGA
40 adenoma of the pancreas 10.4 SYP SST CHGA
41 gastrointestinal neuroendocrine tumor 10.4 SYP SST CHGA
42 adult teratoma 10.4 CHGA AFP
43 esophageal neuroendocrine tumor 10.4 CHGA SYP
44 pituitary carcinoma 10.4 SST GNAS CHGA
45 carcinoid tumors, intestinal 10.4 SYP SST CHGA
46 autoimmune atrophic gastritis 10.4 GAST CHGA
47 urinary bladder small cell neuroendocrine carcinoma 10.4 CHGA SYP
48 atypical follicular adenoma 10.4 TG SYP CHGA
49 gender identity disorder 10.4 ESR1 CYP19A1 AR
50 male reproductive system disease 10.4 AR AREG CHGA

Graphical network of the top 20 diseases related to Endocrine Gland Cancer:



Diseases related to Endocrine Gland Cancer

Symptoms & Phenotypes for Endocrine Gland Cancer

MGI Mouse Phenotypes related to Endocrine Gland Cancer:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.45 ADAM17 AFP AR AREG BRCA1 CHGA
2 endocrine/exocrine gland MP:0005379 10.4 ADAM17 AFP AR AREG BRCA1 CHGA
3 immune system MP:0005387 10.39 ADAM17 AR AREG BRCA1 CYP19A1 ESR1
4 growth/size/body region MP:0005378 10.36 ADAM17 AR AREG BRCA1 CHGA CYP19A1
5 behavior/neurological MP:0005386 10.32 AFP AR BRCA1 CYP19A1 ESR1 GNAS
6 cardiovascular system MP:0005385 10.32 ADAM17 AR AREG BRCA1 CHGA CYP19A1
7 digestive/alimentary MP:0005381 10.31 ADAM17 AR AREG BRCA1 CYP19A1 ESR1
8 hematopoietic system MP:0005397 10.31 ADAM17 AR AREG BRCA1 CYP19A1 ESR1
9 mortality/aging MP:0010768 10.3 ADAM17 AFP AR AREG BRCA1 CHGA
10 integument MP:0010771 10.15 ADAM17 AR AREG BRCA1 CYP19A1 ESR1
11 nervous system MP:0003631 10.15 ADAM17 AR BRCA1 CHGA CYP19A1 ESR1
12 muscle MP:0005369 10.09 ADAM17 AR BRCA1 CHGA CYP19A1 ESR1
13 adipose tissue MP:0005375 10.07 AR BRCA1 CYP19A1 ESR1 GNAS TG
14 normal MP:0002873 10.06 ADAM17 AR BRCA1 CYP19A1 ESR1 GNAS
15 limbs/digits/tail MP:0005371 10.02 ADAM17 AR BRCA1 ESR1 GNAS RET
16 neoplasm MP:0002006 10.01 AFP AR BRCA1 ESR1 GAST GNAS
17 reproductive system MP:0005389 9.9 ADAM17 AFP AR AREG BRCA1 CHGA
18 renal/urinary system MP:0005367 9.8 AR BRCA1 CHGA CYP19A1 ESR1 GNAS
19 respiratory system MP:0005388 9.56 ADAM17 BRCA1 ESR1 GNAS KDR MLH1
20 skeleton MP:0005390 9.32 ADAM17 AR BRCA1 CYP19A1 ESR1 GNAS

Drugs & Therapeutics for Endocrine Gland Cancer

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Afinitor 18 49 EVEROLIMUS Novartis March 2009
2
Sutent 18 49 SUNITINIB MALATE Pfizer May 2011/ January 2006

Drugs for Endocrine Gland Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 3 95058-81-4 60750
2
Pancrelipase Approved, Investigational Phase 3 53608-75-6
3 Anti-Infective Agents Phase 3
4 Immunologic Factors Phase 3
5 Immunoglobulins Phase 3
6 Antiviral Agents Phase 3
7 Antibodies Phase 3
8 Antibodies, Monoclonal Phase 3
9 Immunosuppressive Agents Phase 3
10 pancreatin Phase 3
11 Antimetabolites, Antineoplastic Phase 3
12 Antimetabolites Phase 3
13 Gastrointestinal Agents Phase 3
14
Denosumab Approved Phase 2 615258-40-7
15
Vincristine Approved, Investigational Phase 2 57-22-7, 2068-78-2 5978
16
Mitotane Approved Phase 2 53-19-0 4211
17
Doxorubicin Approved, Investigational Phase 2,Phase 1 23214-92-8 31703
18
Etoposide Approved Phase 2 33419-42-0 36462
19
Doxil Approved June 1999 Phase 2,Phase 1 31703
20 Calcium, Dietary Phase 2
21 Diphosphonates Phase 2
22 Bone Density Conservation Agents Phase 2
23 Anti-Bacterial Agents Phase 2,Phase 1
24 Topoisomerase Inhibitors Phase 2,Phase 1
25 Antibiotics, Antitubercular Phase 2,Phase 1
26 Etoposide phosphate Phase 2
27 Krestin Phase 2
28 Antineoplastic Agents, Hormonal Phase 2
29 Antineoplastic Agents, Phytogenic Phase 2
30 Antimitotic Agents Phase 2
31 Liver Extracts Phase 1
32
Racepinephrine Approved 329-65-7 838
33
Epinephrine Approved, Vet_approved 51-43-4 5816
34 Epinephryl borate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 QUILT-2.014: Gemcitabine and AMG 479 in Metastatic Adenocarcinoma of the Pancreas Terminated NCT01231347 Phase 3 AMG 479;Placebo;AMG 479;gemcitabine
2 Study of Denosumab in the Treatment of Hypercalcemia of Malignancy in Subjects With Elevated Serum Calcium Completed NCT00896454 Phase 2 denosumab
3 Surgery Plus Chemotherapy (Doxorubicin, Vincristine and Etoposide), Mitotane, and Tariquidar to Treat Adrenocortical Cancer Completed NCT00071058 Phase 2 XR9576 (Tariquidar)
4 Prospective Study Assessing Thyroidectomy Using Robot Active, not recruiting NCT02839655 Phase 2
5 Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors Completed NCT00019630 Phase 1 doxorubicin HCl liposome
6 Genetic Evaluation of Families With Endocrine Cancers Completed NCT01794676
7 Feasibility of Activity Monitoring in Patients With Cancer: Physical Activity Monitoring in Cancer Patients (PAMCaP) Completed NCT02583815
8 B-Receptor Signaling in Cardiomyopathy Completed NCT01135849
9 Prospective Comprehensive Molecular Analysis of Endocrine Neoplasms Recruiting NCT01005654

Search NIH Clinical Center for Endocrine Gland Cancer

Cochrane evidence based reviews: endocrine gland neoplasms

Genetic Tests for Endocrine Gland Cancer

Genetic tests related to Endocrine Gland Cancer:

# Genetic test Affiliating Genes
1 Neoplasm of the Endocrine System 29
2 Endocrine Cancer 29

Anatomical Context for Endocrine Gland Cancer

MalaCards organs/tissues related to Endocrine Gland Cancer:

41
Thyroid, Lung, Liver, Colon, Tongue, Breast, Pancreas

The Foundational Model of Anatomy Ontology organs/tissues related to Endocrine Gland Cancer:

19
Endocrine System

Publications for Endocrine Gland Cancer

Articles related to Endocrine Gland Cancer:

# Title Authors Year
1
Endocrine gland cancer. ( 8001005 )
1995

Variations for Endocrine Gland Cancer

Expression for Endocrine Gland Cancer

Search GEO for disease gene expression data for Endocrine Gland Cancer.

Pathways for Endocrine Gland Cancer

Pathways related to Endocrine Gland Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.49 AR ESR1 GNAS MLH1 RET
2 11.75 AR BRCA1 CYP19A1 ESR1
3 11.62 GCG GNAS IAPP VIP
4
Show member pathways
10.59 AR BRCA1 ESR1 GCG
5 10.17 GAST VIP
6 9.56 CYP19A1 ESR1

GO Terms for Endocrine Gland Cancer

Cellular components related to Endocrine Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 AFP AREG CCL15 CHGA GAST GCG
2 extracellular region GO:0005576 9.36 AFP CCL15 CHGA GAST GCG GNAS

Biological processes related to Endocrine Gland Cancer according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.92 AREG CCL15 GAST GCG GNAS IAPP
2 positive regulation of cell proliferation GO:0008284 9.89 ADAM17 AR AREG KDR VIP
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.78 CCL15 GCG KDR RET
4 positive regulation of MAPK cascade GO:0043410 9.67 AR IAPP KDR RET
5 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.56 GCG GNAS IAPP VIP
6 cell-cell signaling GO:0007267 9.55 AR AREG CCL15 IAPP SST
7 positive regulation of histone H3-K4 methylation GO:0051571 9.51 BRCA1 GCG
8 prostate gland growth GO:0060736 9.46 AR CYP19A1
9 epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 9.43 AREG ESR1
10 regulation of signaling receptor activity GO:0010469 9.23 AREG CCL15 GAST GCG IAPP SST
11 mammary gland alveolus development GO:0060749 9.13 AR AREG ESR1
12 signal transduction GO:0007165 10.06 AR CCL15 ESR1 GAST GCG GNAS

Molecular functions related to Endocrine Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.1 GAST GCG IAPP SST TG VIP

Sources for Endocrine Gland Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....